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3. IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis

Author

L. Tavares, Paula Ministro, Paula Peixe, Marília Cravo, Mariana Brito, de Deus, Luís Araújo Correia, P. Ferreira, Paula Sousa, José Velosa, Velho S, Maio Rf, and Moura-Santos P

Subjects
Male, Anti-Inflammatory Agents, Azathioprine, Severity of Illness Index, Gastroenterology, chemistry.chemical_compound, Adrenal Cortex Hormones, Risk Factors, Anti-inflamatórios, IL23R polymorphisms, Mesalamine, Age Factors, Antibodies, Monoclonal, Middle Aged, Ulcerative colitis, Phenotype, Treatment Outcome, Female, medicine.symptom, medicine.drug, Adult, Pancolitis, medicine.medical_specialty, Single-nucleotide polymorphism, Anti-Inflammatory agents, Polymorphism, Single Nucleotide, Gastrointestinal Agents, Colite ulcerosa, Refractory, Mesalazine, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genotyping, Retrospective Studies, Portugal, Hepatology, business.industry, Receptors, Interleukin, Single nucleotide polymorphisms, medicine.disease, Infliximab, chemistry, Immunology, Colitis, Ulcerative, business
Abstract

OBJECTIVE: We aimed to identify the clinical and genetic [IL23 receptor (IL23R) single nucleotide polymorphisms (SNPs)] predictors of response to therapy in patients with ulcerative colitis. PATIENTS AND METHODS: A total of 174 patients with ulcerative colitis, 99 women and 75 men, were included. The mean age of the patients was 47±15 years and the mean disease duration was 11±9 years. The number of patients classified as responders (R) or nonresponders (NR) to several therapies was as follows: 110 R and 53 NR to mesalazine (5-ASA), 28 R and 20 NR to azathioprine (AZT), 18 R and 7 NR to infliximab. Clinical and demographic variables were recorded. A total of four SNPs were studied: IL23R G1142A, C2370A, G43045A, and G9T. Genotyping was performed by real-time PCR using Taqman probes. RESULTS: Older patients were more prone to respond to 5-ASA (P=0.004), whereas those with pancolitis were less likely to respond to such therapies (P=0.002). Patients with extraintestinal manifestations (EIMs) were less likely to respond to 5-ASA (P=0.001), AZT (P=0.03), and corticosteroids (P=0.06). Carriers of the mutant allele for IL23R SNPs had a significantly higher probability of developing EIMs (P

Published
2014

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