Search

"Nasal hyperreactivity" is a key feature in various phenotypes of upper airway diseases, whereby reactions of the nasal epithelium to diverse chemical and physical stimuli are exacerbated. In this review, we illustrate how nasal hyperreactivity can result from at least three types of mechanisms: (1) impaired barrier function, (2) hypersensitivity to external and endogenous stimuli, and (3) potentiation of efferent systems. We describe the known molecular basis of hyperreactivity related to the functional impairment of epithelial cells and somatosensory innervation, and indicate that the thermal, chemical, and mechanical sensors determining hyperreactivity in humans remain to be identified. We delineate research directions that may provide new insights into nasal hyperreactivity associated with rhinitis/rhinosinusitis pathophysiology and therapeutics. The elucidation of the molecular mechanisms underlying nasal hyperreactivity is essential for the treatment of rhinitis according to the precepts of precision medicine.

Additional file 2. Self-rated change in the six dimensions of Positive Health compared to the year before the COVID-19 pandemic in older individuals living in the Netherlands (n=834).

The user manual of PCLake. This document contains exercises and examples for the application of PCLake., Corrected typographical errors.

Additional file 3. Self-rated change (%), compared to before the COVID-19 pandemic, in the six dimensions of Positive Health of older individuals living in the Netherlands depending on sex, age, living situation and self-rated general health (n=834). * = statistically significant.

Additional file 1. Original response categories and conversion of the response categories for data analysis.

On March 11th 2020, the World Health Organization (WHO) declared COVID-19 pandemic, with subsequent profound impact on the entire health care system. During the COVID-19 outbreak, activities in the rhinology outpatient clinic and operation rooms are limited to emergency care only. Health care practitioners are faced with the need to perform rhinological and skull base emergency procedures in patients with a positive or unknown COVID-19 status. This article aims to provide recommendations and relevant information for rhinologists, based on the limited amount of (anecdotal) data, to guarantee high-quality patient care and adequate levels of infection prevention in the rhinology clinic.

Dutch society makes use of a variety of goods and services provided by ecosystems – generally referred to as ecosystem services. A visible record of the status and trends in ecosystem services can help government and industry to incorporate the interests of nature and the environment in the Netherlands into decisionmaking processes. The results show that although Dutch ecosystems make a valuable contribution towards the need for the sustainable provision of goods and services, they do not satisfy the entire demand. Moreover, over the past 20 years the demand for most ecosystem services has risen faster than the supply. De Nederlandse samenleving gebruikt verschillende goederen en diensten die ecosystemen leveren – de zogeheten ecosysteemdiensten. Het zichtbaar maken van de toestand en trends van ecosysteemdiensten in Nederland kan helpen bij de oordeelsvorming en besluitvorming van natuur in Nederland door de overheid en het bedrijfsleven. Resultaten laten zien dat, alhoewel Nederlandse ecosystemen een belangrijke bijdrage leveren aan de behoefte aan een duurzame voorziening van goederen en diensten, ze niet voorzien in de totale vraag. Bovendien geldt dat voor de meerderheid van de ecosysteemdiensten de vraag ernaar sneller toeneemt dan het aanbod in de afgelopen twintig jaar.

Gevaert, Philippe/0000-0002-1629-8468; Hox, Valerie/0000-0003-2390-294X; Demoly, Pascal/0000-0001-7827-7964; Hellings, Peter W/0000-0001-6898-688X; N.G., Papadopoulos/0000-0002-4448-3468; Van Gerven, Laura/0000-0002-5325-7956; Cingi, Cemal/0000-0003-3934-5092; Seys, Sven/0000-0002-4399-9892 WOS: 000413151200004 PubMed: 28474799 This EAACI position paper aims at providing a state-of-the-art overview on nonallergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as nonallergic noninfectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of a minimum of two nasal symptoms such as nasal obstruction, rhinorrhea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens. Symptoms of NAR may have a wide range of severity and be either continuously present and/or induced by exposure to unspecific triggers, also called nasal hyperresponsiveness (NHR). NHR represents a clinical feature of both AR and NAR patients. NAR involves different subgroups: drug-induced rhinitis, (nonallergic) occupational rhinitis, hormonal rhinitis (including pregnancy rhinitis), gustatory rhinitis, senile rhinitis, and idiopathic rhinitis (IR). NAR should be distinguished from those rhinitis patients with an allergic reaction confined to the nasal mucosa, also called entopy or local allergic rhinitis (LAR). We here provide an overview of the current consensus on phenotypes of NAR, recommendations for diagnosis, a treatment algorithm, and defining the unmet needs in this neglected area of research.

ispartof: B-ENT vol:15 issue:3 pages:161-167 status: published

This EAACI position paper aims at providing a state-of-the-art overview on nonallergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as nonallergic noninfectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of a minimum of two nasal symptoms such as nasal obstruction, rhinorrhea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens. Symptoms of NAR may have a wide range of severity and be either continuously present and/or induced by exposure to unspecific triggers, also called nasal hyperresponsiveness (NHR). NHR represents a clinical feature of both AR and NAR patients. NAR involves different subgroups: drug-induced rhinitis, (nonallergic) occupational rhinitis, hormonal rhinitis (including pregnancy rhinitis), gustatory rhinitis, senile rhinitis, and idiopathic rhinitis (IR). NAR should be distinguished from those rhinitis patients with an allergic reaction confined to the nasal mucosa, also called “entopy” or local allergic rhinitis (LAR). We here provide an overview of the current consensus on phenotypes of NAR, recommendations for diagnosis, a treatment algorithm, and defining the unmet needs in this neglected area of research. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis. The debates started with an overview of the current state of the art, including weaknesses and strengths of the current practices, followed by the identification of essential research needs, thoroughly integrated in the context of Precision Medicine (PM), with personalized care, prediction of success of treatment, participation of the patient and prevention of disease as key principles for improving current clinical practices. This report provides a concise summary of the outcomes of the brainstorming sessions of the European Rhinology Research Forum 2016.

This study presents FABM-PCLake, a complete redesign of the PCLake aquatic ecosystem model, which we implemented into the Framework for Aquatic Biogeochemical Models (FABM). In contrast to the original model, which was designed for temperate, fully mixed freshwater lakes, the new FABM-PCLake represents an integrated aquatic ecosystem model that enables simulations of hydrodynamics and biogeochemical processes for zero dimensional, one-dimensional as well as three-dimensional heterogeneous environments. FABM-PCLake describes interactions between multiple trophic levels, including piscivorous, zooplanktivorous and benthivorous fish, zooplankton, zoobenthos, three groups of phytoplankton and rooted macrophytes. The model also accounts for oxygen dynamics and nutrient cycling for nitrogen, phosphorus and silicon, both within the pelagic and benthic domains. FABM-PCLake includes a two-way communication between the biogeochemical processes and the physics, where some biogeochemical state variables (e.g., phytoplankton) influence light attenuation and thereby the spatial and temporal distributions of light and heat. At the same time, the physical environment, including water currents, light and temperature influence a wide range of biogeochemical processes. The model enables studies on ecosystem dynamics in physically heterogeneous environments (e.g., stratifying water bodies, and water bodies with horizontal gradient in physical and biogeochemical properties), and through FABM also enables data assimilation and multi-model ensemble simulations. Examples of relevant model applications include climate change impact studies and environmental impact assessment scenarios for lakes and reservoirs worldwide.

Sulfaat is een belangrijke stof in sloten in veenweidegebieden. Het wordt in de zuurstofloze waterbodem door micro-organismen omgezet in sulfide, dat zich bindt aan ijzer. Daardoor komt fosfaat vrij, wat slecht is voor de ecologische kwaliteit van het slootwater. De gedachte was altijd dat de inlaat van gebiedsvreemd water in de polders de grootste bron van sulfaat is. De laatste jaren is duidelijk geworden dat het sulfaat vooral afkomstig is uit de veenweidebodem zelf. In de Krimpenerwaard gaat het om 75%. Het inlaatwater blijkt de sulfaatconcentraties in de gemiddelde veensloot zelfs omlaag te brengen!

Sulfaat is een belangrijke stof in sloten in veenweidegebieden. Het wordt in de zuurstofloze waterbodem door micro-organismen omgezet in sulfide, dat zich bindt aan ijzer. Daardoor komt fosfaat vrij, wat slecht is voor de ecologische kwaliteit van het slootwater. De gedachte was altijd dat de inlaat van gebiedsvreemd water in de polders de grootste bron van sulfaat is. De laatste jaren is duidelijk geworden dat het sulfaat vooral afkomstig is uit de veenweidebodem zelf. In de Krimpenerwaard gaat het om 75%. Het inlaatwater blijkt de sulfaatconcentraties in de gemiddelde veensloot zelfs omlaag te brengen!

Les valeurs du temps de conversion de spin dans Cu(CH 3 COO) 2 •H 2 O, mesurees en fonction de l'inverse de la temperature (15-30 K) varient exponentiellement sur trois ordres de grandeurs. En supposant des interactions intra-dipolaires comme etant le mecanisme principal de conversion de spin, ce comportement et les valeurs du rapport de relaxation sont entierement expliquees. Les mesures du temps de conversion en fonction du champ magnetique et de l'angle cristallin confirment ceci