5 results on '"Van Den Eeden S"'
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2. Big' Electronic Health Records Data in Environmental Epidemiology
- Author
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van den Eeden S
- Subjects
Global and Planetary Change ,Geography ,Variation (linguistics) ,Epidemiology ,Health, Toxicology and Mutagenesis ,Environmental health ,Public Health, Environmental and Occupational Health ,Health records ,Pollution ,Environmental epidemiology - Published
- 2019
3. Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
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Fang, J, Jia, J, Makowski, M, Xu, M, Wang, Z, Zhang, T, Hoskins, Jw, Choi, J, Han, Y, Zhang, M, Thomas, J, Kovacs, M, Collins, I, Dzyadyk, M, Thompson, A, O'Neill, M, Das, S, Lan, Q, Koster, R, Solomon, Rs, Kraft, P, Wolpin, Bm, Jansen, Pwtc, Olson, S, Mcglynn, Ka, Kanetsky, Pa, Chatterjee, N, Barrett, Jh, Dunning, Am, Taylor, Jc, Newton Bishop, Ja, Bishop, Dt, Andresson, T, Petersen, Gm, Amos, Ci, Iles, Mm, Nathanson, Kl, Landi, Mt, Vermeulen, M, Brown, Km, Amundadottir, Lt, Canzian, F, Kooperberg, C, Arslan, Aa, Bracci, Pm, Buring, J, Duell, Ej, Gallinger, S, Jacobs, Ej, Kamineni, A, Van Den Eeden, S, Klein, Ap, Kolonel, Ln, Li, D, Olson, Sh, Risch, Ha, Sesso, Hd, Visvanathan, K, Zheng, W, Albanes, D, Austin, Ma, Boutron Ruault, Mc, Bueno de Mesquita, Hb, Cotterchio, M, Gaziano, Jm, Giovannucci, El, Goggins, M, Gross, M, Hassan, M, Helzlsouer, Kj, Holly, Ea, Hunter, Dj, Jenab, M, Kaaks, R, Key, Tj, Khaw, Kt, Krogh, V, Kurtz, Rc, Lacroix, A, Le Marchand, L, Mannisto, S, Patel, Av, Peeters, Phm, Riboli, E, Shu, Xo, Sund, M, Thornquist, M, Tjønneland, A, Tobias, Gs, Trichopoulos, D, Wactawski Wende, J, Yu, H, Yu, K, Zeleniuch Jacquotte, A, Hoover, R, Hartge, P, Fuchs, C, Chanock, Sj, Stevens, V, Caporaso, Ne, Brennan, P, Mckay, J, Wu, X, Hung, Rj, Mclaughlin, Jr, Bickeboller, H, Risch, A, Wichmann, E, Houlston, R, Mann, G, Hopper, J, Aitken, J, Armstrong, B, Giles, G, Holland, E, Kefford, R, Cust, A, Jenkins, M, Schmid, H, Puig, S, Aguilera, P, Badenas, C, Barreiro, A, Carrera, C, Gabriel, D, Xavier, Pg, Iglesias Garcia, P, Malvehy, J, Mila, M, Pigem, R, Potrony, M, Batille, Ja, Marti, Gt, Hayward, N, Martin, N, Montgomery, G, Duffy, D, Whiteman, D, Gregor, Sm, Calista, D, Landi, G, Minghetti, P, Arcangeli, F, Bertazzi, Pa, Ghiorzo, Paola, Bianchi, Giovanna, Pastorino, Lorenza, Bruno, William, Andreotti, Virginia, Queirolo, P, Spagnolo, Francesco, Mackie, R, Lang, J, Gruis, N, van Nieuwpoort, Fa, Out, C, Bergman, W, Kukutsch, N, Bavinck, Jnb, Bakker, B, van der Stoep, N, Ter Huurne, J, van der Rhee, H, Bekkenk, M, Snels, D, van Praag, M, Brochez, L, Gerritsen, R, Crijns, M, Vasen, H, Janssen, B, Ingvar, C, Olsson, H, Jonsson, G, Borg, A, Harbst, K, Nielsen, K, Zander, As, Molvern, A, Helsing, P, Andresen, Pa, Rootwelt, H, Akslen, La, Bressac de Paillerets, B, Demenais, F, Avril, Mf, Chaudru, V, Jeannin, P, Lesueur, F, Maubec, E, Mohamdi, H, Bossard, M, Vaysse, A, Boitier, F, Caron, O, Caux, F, Dalle, S, Dereure, O, Leroux, D, Martin, L, Mateus, C, Robert, C, Stoppa Lyonnet, D, Thomas, L, Wierzbicka, E, Elder, D, Ming, M, Mitra, N, Debniak, T, Lubinski, J, Hocevar, M, Novakovic, S, Peric, B, Skerl, P, Hansson, J, Hoiom, V, Freidman, E, Azizi, E, Baron Epel, O, Scope, A, Pavlotsky, F, Cohen Manheim, I, Laitman, Y, Harland, M, Randerson Moor, J, Laye, J, Davies, J, Nsengimana, J, O'Shea, S, Chan, M, Gascoyne, J, Tucker, Ma, Goldstein, Am, and Yang, X. r.
- Subjects
0301 basic medicine ,Male ,Lung Neoplasms ,Skin Neoplasms ,General Physics and Astronomy ,Genome-wide association study ,VARIANTS ,Histones ,Skin cancer ,RNA, Small Interfering ,Melanoma ,Telomerase ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Pancreas cancer ,Regulation of gene expression ,Genetics ,Zinc finger ,Gene knockdown ,Multidisciplinary ,Proteomics and Chromatin Biology ,TRICL Consortium ,Chromosome Mapping ,GenoMEL Consortium ,PANCREATIC-CANCER ,Multidisciplinary Sciences ,DNA-Binding Proteins ,Gene Expression Regulation, Neoplastic ,Science & Technology - Other Topics ,Chromosomes, Human, Pair 5 ,Female ,Lung cancer ,Signal Transduction ,SUSCEPTIBILITY LOCI ,Science ,Locus (genetics) ,Single-nucleotide polymorphism ,PROMOTES GROWTH ,Biology ,Polymorphism, Single Nucleotide ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,LUNG-CANCER ,Testicular Neoplasms ,Cell Line, Tumor ,MD Multidisciplinary ,Humans ,Genetic Predisposition to Disease ,QUANTITATIVE PROTEOMICS ,GENOME-WIDE ASSOCIATION ,Gene ,PanScan Consortium ,Càncer de pell ,Càncer de pàncrees ,Alleles ,Science & Technology ,Kirurgi ,HUMAN-CELLS ,Telomere Homeostasis ,Correction ,General Chemistry ,Molecular biology ,TERT-CLPTM1L LOCUS ,Telomere ,Pancreatic Neoplasms ,030104 developmental biology ,Genetic Loci ,TELOMERE LENGTH ,Càncer de pulmó ,Surgery ,Genètica ,Genome-Wide Association Study ,Transcription Factors - Abstract
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional gene silencing of this regulatory element repressed TERT expression in an allele-specific manner. Proteomic analysis identifies allele-preferred binding of Zinc finger protein 148 (ZNF148) to rs36115365-C, further supported by binding of purified recombinant ZNF148. Knockdown of ZNF148 results in reduced TERT expression, telomerase activity and telomere length. Our results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele., Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.
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- 2017
4. Air Pollution and Health Care Costs in Oakland, CA
- Author
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Sidney S, Alexeeff S, van den Eeden S, Messier K, Portier C, Roy A, Shan J, Ray G, and Apte J
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Global and Planetary Change ,business.industry ,Epidemiology ,Environmental health ,Health, Toxicology and Mutagenesis ,Health care ,Air pollution ,medicine ,Public Health, Environmental and Occupational Health ,medicine.disease_cause ,business ,Pollution - Published
- 2019
5. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
- Author
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Carlo Ferrarese, Lorene M. Nelson, Caroline M. Tanner, Brian K. Fiske, George D. Mellick, Richard M. Myers, Beate Ritz, Grazia Annesi, Karin Wirdefeldt, Christine Van Broeckhoven, Karen Marder, Marie Dehem, Stewart A. Factor, Donald S. Higgins, John G. Nutt, Stephen K. Van Den Eeden, Andrea Carmine Belin, Cyrus P. Zabetian, Rejko Krüger, Haydeh Payami, Jennifer S. Montimurro, Georgios M. Hadjigeorgiou, John P. A. Ioannidis, Hideshi Kawakami, Audrey Southwick, Ali Samii, Alexis Elbaz, Richard Mayeux, Thomas A Trikalinos, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Epidemiology, Department of Health Research and Policy, Stanford University, New York State Department of Health [Albany], Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, The Michael J Fox Foundation for Parkinson's Research, Institute of Neurological Sciences, National Research Council [Italy] (CNR), Neuroscience Department, Karolinska Institutet [Stockholm], Department of Neurology, Emory University [Atlanta, GA], Department of Neuroscience-Section of Neurology, Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), School of Medicine, Larissa, University of Thessaly [Volos] (UTH), Parkinson's Disease and Movement Disorder Clinic, Albany Medical College, Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Center of Neurology and Hertie-Institute for Clinical Brain Research, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, The Gertrude H Sergivesky Center, Columbia University College of Physicians and Surgeons, Eskitis Institute for Cell and Molecular Therapies, Griffi th University, Oregon Health and Science University [Portland] (OHSU), Department of Epidemiology, University of California [Los Angeles] (UCLA), University of California-University of California, Parkinson Disease Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, The Parkinson's Institute, The Parkinson's Institute, Sunnyvale, Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerpen, Division of Research, Kaiser Permanente, Department of Medical Epidemiology and Biostatistics (MEB), Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, University of Washington [Seattle], Genoscreen, Genoscreen, Lille, Department of Genetics [Stanford], Stanford Medicine, Stanford University-Stanford University, Theuns, Jessie, Pals, Philippe, Nuytemans, Karen, Pickut, Barbara, Cras, Patrick, De Deyn, Peter Paul, Tzourio, Christophe, University of Ioannina, Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), University of California (UC)-University of California (UC), Elbaz, A, Nelson, L, Payami, H, Ioannidis, J, Fiske, B, Annesi, G, Carmine Belin, A, Factor, S, Ferrarese, C, Hadjigeorgiou, G, Higgins, D, Kawakami, H, Krueger, R, Marder, K, Mayeux, R, Mellick, G, Nutt, J, Ritz, B, Samii, A, Tanner, C, van Broeckhoven, C, van den Eeden, S, Wirdefeldt, K, Zabetian, C, Dehem, M, Montimurro, J, Southwick, A, Myers, R, and Trikalinos, T
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Male ,Linkage disequilibrium ,Polymorphism, Single Nucleotide/*genetics ,Ethnic origin ,Linkage Disequilibrium ,0302 clinical medicine ,Odds Ratio ,Genetics ,MESH: Aged ,0303 health sciences ,MESH: Middle Aged ,MESH: Polymorphism, Single Nucleotide ,MESH: Genetic Predisposition to Disease ,Middle Aged ,MESH: Confidence Intervals ,3. Good health ,MESH: Linkage Disequilibrium ,Meta-analysis ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH: Meta-Analysis ,Single-nucleotide polymorphism ,Biology ,Article ,Parkinson Disease/epidemiology/*genetics ,03 medical and health sciences ,Meta-Analysis as Topic ,Genetic predisposition ,Confidence Intervals ,SNP ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,030304 developmental biology ,Aged ,MED/26 - NEUROLOGIA ,MESH: Humans ,Genetic heterogeneity ,International Cooperation ,Odds ratio ,MESH: Odds Ratio ,MESH: Male ,MESH: International Cooperation ,Genetic Predisposition to Disease ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Parkinson's disease, single-nucleoide polymorphism ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Neurology (clinical) ,MESH: Female ,030217 neurology & neurosurgery ,MESH: Parkinson Disease - Abstract
International audience; BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. FINDINGS: In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966. INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.
- Published
- 2006
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