801 results on '"Università Degli Studi di Siena"'
Search Results
2. Measurement of the forward charged particle pseudorapidity density in pp collisions at s=8 TeV using a displaced interaction point
- Author
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Antchev, G.INRNE-BAS, Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia, Bulgaria, Aspell, P.(CERN, Geneva, Switzerland), Atanassov, I.(CERN, Geneva, Switzerland), Avati, V.(CERN, Geneva, Switzerland), Baechler, J.(CERN, Geneva, Switzerland), Berardi, V.(INFN Sezione di Bari, Bari, Italy), Berretti, M.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Bossini, E.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Bottigli, U.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Bozzo, M.(INFN Sezione di Genova, Genoa, Italy), Brücken, E.(Helsinki Institute of Physics, Helsinki, Finland), Buzzo, A.(INFN Sezione di Genova, Genoa, Italy), Cafagna, F. S.(INFN Sezione di Bari, Bari, Italy), Catanesi, M. G.(INFN Sezione di Bari, Bari, Italy), Covault, C.(Department of Physics, Case Western Reserve University, Cleveland, OH, USA), Csanád, M.(MTA Wigner Research Center, RMKI, Budapest, Hungary), Csörgő, T.(MTA Wigner Research Center, RMKI, Budapest, Hungary), Deile, M.(CERN, Geneva, Switzerland), Doubek, M.(Czech Technical University, Prague, Czech Republic), Eggert, K.(Department of Physics, Case Western Reserve University, Cleveland, OH, USA), Eremin, V.(Ioffe Physical-Technical Institute of Russian Academy of Sciences, St. Petersburg, Russia), Ferro, F.(INFN Sezione di Genova, Genoa, Italy), Fiergolski, A.(INFN Sezione di Bari, Bari, Italy), Garcia, F.(Helsinki Institute of Physics, Helsinki, Finland), Georgiev, V.(University of West Bohemia, Plzen̆, Czech Republic), Giani, S.(CERN, Geneva, Switzerland), Grzanka, L.(AGH University of Science and Technology, Kraków, Poland), Hammerbauer, J.(University of West Bohemia, Plzen̆, Czech Republic), Heino, J.(Helsinki Institute of Physics, Helsinki, Finland), Hilden, T.(Helsinki Institute of Physics, Helsinki, Finland), Karev, A.(CERN, Geneva, Switzerland), Kašpar, J.(Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic), Kopal, J.(Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic), Kundrát, V.(Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic), Lami, S.(INFN Sezione di Pisa, Pisa, Italy), Latino, G.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Lauhakangas, R.(Helsinki Institute of Physics, Helsinki, Finland), Leszko, T.(Warsaw University of Technology, Warsaw, Poland), Lippmaa, E.(National Institute of Chemical Physics and Biophysics NICPB, Tallinn, Estonia), Lippmaa, J.(National Institute of Chemical Physics and Biophysics NICPB, Tallinn, Estonia), Lokajíček, M. V.(Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic), Losurdo, L.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Lo Vetere, M.(INFN Sezione di Genova, Genoa, Italy), Lucas Rodríguez, F.(CERN, Geneva, Switzerland), Macrí, M.(INFN Sezione di Genova, Genoa, Italy), Mäki, T.(Helsinki Institute of Physics, Helsinki, Finland), Mercadante, A.(INFN Sezione di Bari, Bari, Italy), Minafra, N.(Dipartimento Interateneo di Fisica di Bari, Bari, Italy), Minutoli, S.(INFN Sezione di Genova, Genoa, Italy), Nemes, F.(MTA Wigner Research Center, RMKI, Budapest, Hungary), Niewiadomski, H.(CERN, Geneva, Switzerland), Oliveri, E.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Oljemark, F.(Helsinki Institute of Physics, Helsinki, Finland), Orava, R.(Helsinki Institute of Physics, Helsinki, Finland), Oriunno, M.(SLAC National Accelerator Laboratory, Stanford, CA, USA), Österberg, K.(Helsinki Institute of Physics, Helsinki, Finland), Palazzi, P.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Peroutka, Z.(University of West Bohemia, Plzen̆, Czech Republic), Procházka, J.(Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic), Quinto, M.(INFN Sezione di Bari, Bari, Italy), Radermacher, E.(CERN, Geneva, Switzerland), Radicioni, E.(INFN Sezione di Bari, Bari, Italy), Ravotti, F.(CERN, Geneva, Switzerland), Robutti, E.(INFN Sezione di Genova, Genoa, Italy), Ropelewski, L.(CERN, Geneva, Switzerland), Ruggiero, G.(CERN, Geneva, Switzerland), Saarikko, H.(Helsinki Institute of Physics, Helsinki, Finland), Scribano, A.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Smajek, J.(CERN, Geneva, Switzerland), Snoeys, W.(CERN, Geneva, Switzerland), Sodzawiczny, T.(CERN, Geneva, Switzerland), Sziklai, J.(MTA Wigner Research Center, RMKI, Budapest, Hungary), Taylor, C.(Department of Physics, Case Western Reserve University, Cleveland, OH, USA), Turini, N.(Università degli Studi di Siena and Gruppo Collegato INFN di Siena, Siena, Italy), Vacek, V.(Czech Technical University, Prague, Czech Republic), Welti, J.(Helsinki Institute of Physics, Helsinki, Finland), Whitmore, J.(Department of Physics, Penn State University, University Park, PA, USA), Wyszkowski, P.(AGH University of Science and Technology, Kraków, Poland), and Zielinski, K.(AGH University of Science and Technology, Kraków, Poland)
- Abstract
The pseudorapidity density of charged particles dN ch /d η is measured by the TOTEM experiment in proton–proton collisions at s=8 TeV within the range 3.90 MeV/c, produced in inelastic interactions with at least one charged particle in -7
- Published
- 2015
3. Ankle-Brachial Index and cardiovascular events in atrial fibrillation The ARAPACIS Study
- Author
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Violi, F., Davi, G., Proietti, M., Pastori, D., Hiatt, W. R., Corazza, G. R., Perticone, F., Pignatelli, P., Farcomeni, A., Vestri, A. R., Lip, G. Y. H., Basili, S, ARAPACIS (Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study) STUDY Investigators. Alessandri C. (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza-Università di Roma), Serviddio G. (Department of Medical and Surgical Sciences, University of Foggia), (UOC Medicina Generale, Fascetti S., USL 12 Viareggio, Toscana), (UOC Medicina Interna I, Palange P., Dipartimento di Sanità Pubblica, e Malattie Infettive, Sapienza-Università di Roma), Greco, E., (Medicina 3, Bruno G., Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, M., (Dipartimento Biomedico di Medicina Interna e Specialistica, Giammanco A., Università di Palermo), Sposito P. (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro, R., (Istituto di Medicina Interna e Geriatria, De Gennaro L., Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Carulli, L., (UO di Medicina a Indirizzo Nutrizionistico e Metabolico, Pellegrini E., Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Cominacini, L., Mozzini, C., (Dipartimento di Medicina, Pasini A. F., Sezione di Medicina Interna, D, Università di Verona), Sprovieri, M., (UOC Medicina d'Urgenza e PS, Spagnuolo V., Stabilimento Ospedaliero dell'Annunziata, Cosenza), (UOC Medicina Interna per l'Urgenza, Cerqua G., S Giovanni Addolorata, Ao, Cerasola G., Mulé G. (Università degli Studi di Palermo), Barbagallo, M., Lo Sciuto, S., (UOC di Geriatria e Lungodegenza, Monteverde A., Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, A., (UOC Medicina Interna, Lo Gullo A., Università di Messina), Malatino, L., Cilia, C., Terranova, V., (Clinica Medica, Pisano M., Ospedale, Cannizzaro, Università degli Studi di Catania), Pinto, A., Di Raimondo, D., Tuttolomondo, A., (Internal Medicine and Cardio-Angiology Ward, Conigliaro R., Department of Biomedicine and Internal Medicine, University of Palermo), Signorelli S. (Dipartimento di Medicina Interna e Patologia, Università degli Studi di Catania), De Palma, D., Galderisi, M., (Dipartimento di Medicina Clinica e Sperimentale, Cudemo G., AUP Federico II di Napoli), Galletti, F., (Dipartimento di Medicina Clinica e Chirurgia, Fazio V., Università di Napoli Federico II), De Luca, N., (Centro Ipertensione, Meccariello A., AUO Federico II, Napoli), Caputo, D., (UO Medicina Interna, De Donato M. T., Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, A., (Divisione di Medicina Interna, Bresciani A., Cardarelli, Osp. A., (V Divisione Medicina Interna ed Immunoallergologia, Giunta R., Policlinico, Sun, Utili, R., (Medicina Infettivologica e dei Trapianti, Iorio V., Seconda Università di Napoli, AORN dei Colli-Monaldi), Adinolfi, L. E., Sellitto, A., (Medicina Interna, Iuliano N., Ospedale di Marcianise), Bellis, P., (UOC Medicina Interna e di Urgenza e Pronto Soccorso, Tirelli P., del Loreto Nuovo, P. O. S. M., Loreto, Mare), (Clinica Medica 5, Sacerdoti D., Dipartimento di Medicina DIMED, Università degli Studi di Padova), (UO Medicina Interna Arezzo, Vanni D., Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, L., Ciacciarelli, M., (Department of Medico-Surgical Sciences and Biotechnology, Pacelli A., Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli A. (UOS Malattie Cardiovascolari Dipartimento di Scienze Mediche Chirurgiche e Neuroscienze, Università di Siena), Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., (UOC di Medicina Geriatrica e Riabilitazione, Verrusio W., Sapienza-Università di Roma, Nobili, L., Tarquinio, N., (UO Medicina 'SS Benvenuto e Rocco', Pellegrini F., Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), (UOS Breve Osservazione, Vincentelli G. M., Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, F., (UOC Medicina Interna, Santini C., Ospedale, Vannini, Letizia, C., Petramala, L., (UOD Ipertensione Secondaria, Zinnamosca L., Dipartimento di Medicina Interna, e Specialità Mediche, Minisola, S., Cilli, M., Savoriti, C., (UOC Medicina Interna F e Malattie Metaboliche dell'osso- Sapienza-Università di Roma), Colangelo L., Falaschi, P., Martocchia, A., (UO Geriatria, Pastore F., Andrea, Azienda Ospedaliera S., Facoltà diMedicina, e Psicologia, Bertazzoni, G., (UOC Medicina d’Urgenza, Attalla El Halabieh E., Dipartimento di Emergenza ed Accettazione, Paradiso, M., Lizzi, E. M., (Ospedale San Giovanni Battista, Timmi S., Ordine di Malta, (Medicina Interna II, Battisti P., Ospedale San Giovanni-Addolorata, (UOC Medicina Interna, Cerci S., Ospedali Riuniti Frascati, Marino), (UOC Cardiologia-UTIC, Ciavolella M., Ospedale di Frascati, (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche e Renali, Di Veroli C., Casa di Cura 'San Domenico', Malci, F., (UOC di Medicina Interna, De Ciocchis A., Ospedale, ASL Roma, G, Subiaco), Abate, D. (Az., Castellino, P., Zanoli, L., (UOC Medicina Interna, Fidone F., Dipartimento di Medicina Clinica, e Sperimentale, Mannarino, E., Pasqualini, L., (Medicina Interna, Oliverio G., Università degli Studi di Perugia), Pende, A., (Clinica di Medicina Interna 1, Artom N., Università di Genova, San Martino - IST), IRCCS Az. Osp. Univ., Ricchio, R., (UOC Geriatria, Fimognari F. L., Azienda Ospedaliera di Cosenza, Alletto, M., (Unità Operativa di Medicina, Messina S., Elia, Ospedale S., Caltanissetta), Sesti, G., Arturi, F., Fiorentino, T. V., (Università degli Studi, Pedace E., UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino, P. E., Carullo, G., Maio, R., (Cattedra di Medicina Interna, Sciacqua A., UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, P., (UOC Medicina Interna e Reumatologia, Spagnuolo V., Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), (UO Lungodegenza, Battaglia G., Serra San Bruno, S. O., ASP Vibo Valentia), Atzori, S., (Clinica Medica, Delitala G., Aou, Sassari), Angelucci, E., (UOC di Clinica Medica, Sestili S., PO Clinicizzato di Chieti), Traisci, G., (UOC Medicina Interna 2, De Feudis L., PO di Pescara), Di Michele, D., (UOC Medicina Interna, Fava A., Asl, Teramo), Balsano, C., (Dipartimento di Medicina Interna e Sanità Pubblica, De Ciantis P., Università, dell'Aquila), Desideri, G., (UOC Geriatria e Lungodegenza Geriatrica, Camerota A., Dipartimento Medico ORM, Avezzano), Po, Mezzetti M. (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, P., Vedovati, C., (Dipartimento di Medicina Interna, Fierro T., Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), (Centro Aterosclerosi, Puccetti L., Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, M., (UO Geriatria, Mussi C., Boddi, M., Savino, A., Contri, S., (Dipartimento di Medicina Sperimentale e Clinica, Degl'Innocenti G., Università degli Studi di Firenze), Saller, A., (Clinica Medica 1, Fabris F., Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova), Pesavento, R., Filippi, L., (Dipartimento di Scienze Cardiologiche, Vedovetto V., Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), (Clinica Medica IV, Puato M., Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, F., (UOA Medicina, Treleani M., Policlinico, Universitario, De Luca, E., De Zaiacomo, F., (Clinica Geriatrica, Giantin V., Università di Padova), (Medicina Interna 1, Semplicini A., Giovanni e Paolo, Ospedale SS., Venezia), Minuz, P., (Sezione di Medicina Interna C, Romano S., Università di Verona, Aoui, Verona), Fantin, F., (Dipartimento di Medicina, Manica A., Sezione di Geriatria, Stockner, I., Pattis, P., Wiedermann, Gutmann B. (Divisione di Medicina Interna-Direttore Prof. J., Ospedale Centrale di Bolzano), Catena, C., Colussi, G., (Clinica Medica, Sechi L. A., Dipartimento di Scienze Mediche Sperimentali, e Cliniche, Università di Udine, Italy), Annoni, G., Bruni, A. A., (Clinica Geriatrica, Castagna A., Università degli Studi di Milano-Bicocca, Dipartimento di Medicina, e Chirurgia, AO San Gerardo, Monza), (Medicina Interna 1, Spinelli D., Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), (Clinica Medica I, Miceli E., Reparto, 11, IRCCS Policlinico San Matteo di Pavia), Schinco, G., (UOC Geriatria, Spreafico S., Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), (UOC Medicina Interna, Secchi B., Ospedale, Bassini, Milano), Vanoli, M., Casella, G., (SC Medicina Interna, Pulixi E. A., Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Sansone, L., (UOC Medicina, Serra M. G., Panico', Azienda Ospedaliera 'Cardinale G., Tricase, (Lecce), Longo, S., (UOC Medicina Interna, Antonaci S., Azienda Ospedaliera Policlinico, Bari), Belfiore, A., Frualdo, M., Palasciano, G., Murri'- Bari), Ricci L. (Clinica Medica 'A., (Struttura Complessa di Medicina Interna, Ventrella F., Cerignola, Asl, Foggia), (UOC Medicina Interna, Bianco C., Tropea), Santovito, D., (Centro di Eccellenza Europeo e di Riferimento Regionale per l'Aterosclerosi, Cipollone F., l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, S., (UO Medicina Interna, Salvati F., Ospedale di Ortona, ASL 02 Abruzzo), Rini, G. B., (UOC Medicina Interna ed Ipertensione, Scozzari F., Dipartimento Biomedico di Medicina Interna, e Specialistica, Giaccone' di Palermo), Policlinico 'P., Muiesan, M. L., Salvetti, M., (Dipartimento di Scienze Cliniche e Sperimentali, Bazza A., Università di Brescia, 2° Medicina Generale Spedali Civili), Picardi, A., Vespasiani-Gentilucci, U., (Medicina Interna e Epatologia, De Vincentis A., Università Campus Bio-Medico, Cosio, P., (Medicina Interna 1, Terzolo M., Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, B., (UO Medicina Interna, Parasporo B., Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, L., Bracco, C., (SC Medicina Interna, Melchio R., Croce e Carle, AO S., Cuneo), Gentili, T., (Medicina Generale - Settore Subintensivo, Salvi A., Azienda Ospedaliero- Universitaria, Ancona), (Medicina Generale - Settore Ordinario, Nitti C., Azienda, Ospedaliero-Universitaria, Gabrielli, A., (Clinica Medica, Martino G. P., Capucci, A., Brambatti, M., (Clinica di Cardiologia, Sparagna A., Ospedale, Torrette, (UO Medicina Generale IV, Tirotta D., Ospedale, Cervesi, Cattolica), Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., (Area Geriatria, Musumeci M., DAI Medicina Interna, Rossi Fanelli, F., Delfino, M., (UOC Medicina Interna H, Giorgi A., Sapienza- Università di Roma), Glorioso, N., Melis, G., Marras, G., (Ambulatorio Ipertensione Arteriosa e Patologie Correlate, Matta M., (UOC Medicina Interna, Sacco A., PO Madonna delle Grazie, Matera), Stellitano, E., (UO Medicina, Scordo A., PO 'Tiberio Evoli', Melito Porto Salvo), Russo, F., (UOC Medicina Generale di Rogliano, Caruso A. A., AO di Cosenza), Porreca, E., (UO Medicina Interna e Geriatria, Tana M., D'Annunzio, Università G., Chieti-Pescara), Ferri, C., (Divisione di Medicina Interna e Nefrologia - Ospedale San Salvatore, Cheli P., Dipartimento, Mesva, (Clinica Medica 'Murri', Portincasa P., Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi G. (ASP Reggio Calabria, Saline Joniche), Giordani, S., (Dipartimento di Scienze Mediche e Chirurgiche, Stanghellini V., Università degli Studi di Bologna), Sabbà C. (UOC Geriatria e Centro di assistenza e ricerca sovraziendale per le malattie rare, Bari), Mancuso, G., Bartone, M., (UOC Medicina Interna, Calipari D., Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, G., (UOC Cardiologia e UTIC, Bellanuova I., Catania), Ferraro M., Marigliano G. (ASP Cosenza), Cozzolino, D., Lampitella, A., (Dipartimento di Internistica Clinica e Sperimentale, Acri V., Seconda Università di Napoli), Galasso, D., Mazzei, F., (RSA Madonna di Porto Gimigliano, Galasso S., Catanzaro), (Azienda Ospedaliera della Provincia di Pavia, Buratti A., UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Pavia), Porta, M., (SC Medicina Interna 1U, Brizzi M. F., Azienda, Ospedaliera, Torino), Fattorini, A., Sampietro, F., (Servizio di Coagulazione ed Unità Ricerca Trombosi, D’Angelo A., IRCCS Ospedale San Raffaele, Manfredini, R., Pala, M., (UOC Clinica Medica, Fabbian F., Anna, Azienda Ospedaliera- Universitaria S., Ferrara), Moroni, C., Valente, L., (Laboratorio di Ecocardiografia- Cardiologia Preventiva, Lopreiato F., DAI Cuore, e Grossi Vasi, (UOC Medicina Interna, Parente F., Lecce), (Immunologia Clinica A, Granata M., Moia, M., (Fondazione IRCCS Ca'Granda, Braham S., Ospedale Maggiore Policlinico, Rossi, M., (Dipartimento di Medicina Clinica e Sperimentale, Pesce M., Università di Pisa), Gentile, A., (UO Medicina, Catozzo V., Ldp, Loreto, Baciarello, G., (UOC Cardiologia Preventiva e Riabilitativa, Cosimati A., Ageno, W., Rancan, E., (Dipartimento di Medicina Clinica e Sperimentale, Guasti L., Università, Dell'Insubria, Varese), Ciccaglioni, A., Negri, S., (Centro Elettro-Stimolazione Cardiaca, Polselli M., Prisco, D., (SOD Patologia Medica, Marcucci R., Aou, Careggi, Firenze), Ferro, D., Cangemi, R., Perri, L., Polimeni, L., Catasca, E., Vicario, T., Russo, R., Saliola, M., Del Ben, M., Angelico, F., Calvieri, C., Bucci, T., (I Clinica Medica, Baratta F., Migliacci, R., Medicina Interna, Porciello G. (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), (Dipartimento BioMedico di Medicina Interna e Specialistica, Corrao S., Università degli Studi di, Palermo). Simi Young Internists (GIS) Group: Anzaldi M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., De Giorgi, A., De Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Raparelli, V., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., Alessandri, C., Serviddio, G., Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, De Cristofaro, R., De Gennaro, L, Carulli, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, Af, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mulé, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Di Raimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, De Palma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, De Luca, N, Meccariello, A, Caputo, D, De Donato, Mt, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, Luigi Elio, Sellitto, A, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L., Tarquinio, N., Pellegrini, F, Vincentelli, G. M., Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S., Cilli, M, Savoriti, C, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F., and DURANTE MANGONI, Emanuele
- Subjects
Male ,Risk ,ABI ,ARAPACIS ,Atrial fibrillation ,Myocardial infarction ,Vascular events ,Hematology ,medicine.medical_specialty ,Aged ,Aged, 80 and over ,Ankle Brachial Index ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Italy ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Survival Analysis ,Vascular Diseases ,Population ,Socio-culturale ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,atrial fibrillation, ABI, ARAPACIS, myocardial infarction, vascular events ,Interquartile range ,Internal medicine ,myocardial infarction ,vascular events ,80 and over ,Medicine ,Cumulative incidence ,030212 general & internal medicine ,education ,Prospective cohort study ,Stroke ,education.field_of_study ,business.industry ,Hazard ratio ,medicine.disease ,Cardiology ,business ,Settore SECS-S/01 - Statistica - Abstract
SummaryAtrial fibrillation (AF) patients are at high risk for thrombotic and vascular events related to their cardiac arrhythmia and underlying systemic atherosclerosis. Ankle-Brachial Index (ABI) is a non-invasive tool in evaluating systemic atherosclerosis, useful in predicting cardiovascular events in general population; no data are available in AF patients. ARAPACIS is a prospective multicentre observational study performed by the Italian Society of Internal Medicine, analysing association between low ABI (≤0.90) and vascular events in NVAF out- or in-patients, enrolled in 136 Italian centres. A total of 2,027 non-valvular AF (NVAF) patients aged > 18 years from both sexes followed for a median time of 34.7 (interquartile range: 22.0–36.0) months, yielding a total of 4,614 patient-years of observation. Mean age was 73 ± 10 years old with 55% male patients. A total of 176 patients (8.7%) experienced a vascular event, with a cumulative incidence of 3.81%/patient-year. ABI≤ 0.90 was more prevalent in patients with a vascular event compared with patients free of vascular events (32.2 vs 20.2%, p< 0.05). On Cox proportional hazard analysis, ABI≤ 0.90 was an independent predictor of vascular events (hazard ratio (HR): 1.394, 95% confidence interval (CI): 1.042–1.866; p=0.02), vascular death (HR: 2.047, 95% CI: 1.255-3.338; p=0.004) and MI (HR: 2.709, 95%> CI: 1.485-5.083; p=0.001). This latter association was also confirmed after excluding patients with previous MI (HR: 2.901, 95% CI: 1.408-5.990, p=0.004). No association was observed between low ABI and stroke/transient ischaemic attack (p=0.91). In conclusion, low ABI is useful to predict MI and vascular death in NVAF patients and may independently facilitate cardiovascular risk assessment in NVAF patients.Note: The review process for this paper was fully handled by C. Weber, Editor in Chief.Listed in the Supplementary Online Appendix Material which is available online at www.thrombosis-online.com.
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- 2016
- Full Text
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4. Nazionalità e lotta di classe. La Nuova Sinistra e i nazionalismi periferici
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Laureatosi in storia presso l’Università della Calabria con una tesi sui rapporti tra socialismo e nazionalismo nell’Irlanda di inizio Novecento, Paolo Perri è attualmente dottorando in Scienze storiche in età contemporanea presso l’Università degli Studi di Siena.
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socialismo ,lcsh:D204-475 ,New Left ,nazionalità ,Nuova Sinistra ,lcsh:History (General) ,separatists ,movimenti separatisti ,lcsh:D1-2009 ,socialism ,nationalities ,Democrazia proletaria ,lcsh:Modern history, 1453 - Abstract
The article aims to address the relationships between the Italian Marxism and the peripheral nationalisms, through the reading of a political history that has its roots in the Cologne Congress of the Communist Party of Italy, and that continued silently until the dissolution of “Democrazia Proletaria”. The program of action adopted in Cologne in 1931, which contemplated the creation of the federation of socialist and sovietic republics of Italy, declared the beginning of a troubled and ambiguous relationship between our national Marxism and the right of self-determination. Immediately after being set aside by the official Communist movement, this issue remerged periodically in the debates of the revolutionary left. From the relationships between “Lotta Continua” and “Potere Operaio” with the Basques and the Irish separatists, to the formal and official recognition by “Democrazia Proletaria” of the Italian peripheral nationalities, there are many elements which call for careful reflections on these issues. The analysis of the political decisions and the struggles waged in the name of self-determination by the New Italian Left could allow a greater understanding of the complex relationship between Socialism and Nationalism that has been too often misunderstood.
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- 2012
5. QUALITY OF LIFE AND TREATMENT SATISFACTION IN PATIENTS WITH TYPE 1 DIABETES: A COMPARISON BETWEEN CONTINUOUS SUBCUTANEOUS INSULIN INJECTION AND MULTIPLE DAILY INJECTIONS
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Nicolucci A, Maione A, Franciosi M, Amoretti R, Busetto R, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, VitacolonnaE on behalf of the EQuality Study Group:LV Cassano, N. Tota Ospedale Generale Regionale Miulli, Acquaviva delle Fonti, V. Cherubini, A. Iannilli Università Politecnica di Ancona, AO G. Salesi, Ancona, A. Corsi, P. Ponzani UOC Genova Ponente, SO La Colletta, Arenzano, V. Montani, P. Di Berardino PO di Atri, M. Velussi Casa di Cura Pineta del Carso, Aurisina, F. Giorgino, V. Gigantelli Università degli Studi di Bari, G. Beltramello, A. Pianta CAD Bassano Bassano del Grappa, R. Trevisan, G. Lepore Ospedali Riuniti di Bergamo, G. Forlani, G. Marchesini Università degli Studi di Bologna, D. Crazzolara, M. Marchesi Ospedale di Bolzano, E. Zarra, B. Agosti Spedali Civili di Brescia, G. Careddu Ospedale SS Prosperie Caterina, Camogli, L. Tomaselli, R. Vigneri Ospedale Garibaldi Nesima, Catania, M. Agrusta, V. Di Blasi PO di Cava dei Tirreni, S. Tumini, MT Anzellotti / E. Vitacolonna, F. Capani Università G. D’Annunzio, Chieti e. Pescara, P. Ruggeri Azienda Istituti Ospedalieri, Cremona, P. Foglini, M. Rossana Ospedale A. Murri, Fermo, S. Toni, MF Reali AO Universitaria degli Studi Meyer, Firenze, M. Nizzoli, S. Aquati Ospedale Morgagni, Forlì, G. d'Annunzio, N. Minuto Istituto G. Gaslini, Genova, L. Cataldi, C. Bordone AO Università San Martino, R. Iannarelli, F. Sciarretta PO San Salvatore, L'Aquila, M. Tagliaferri, MA Lezzi Ospedale G. Vietri, Larino, L. Sciangula, A. Ciucci Ospedale di Mariano Comense, M. Bonomo, E. Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G. Mariani, P. Colapinto AO San Carlo Borromeo, G. Testori, P. Rampini AO Fatebenefratelli e. Oftalmico, R. Bonfanti, F. Meschi / G. Galimberti, A. Laurenzi Istituto Scientifico Ospedale San Raffaele, A. Veronelli, C. Mauri Ospedale San Paolo, C. Tortul, AM Cernigoi Ospedale San Paolo, Monfalcone, ME De Feo, M. Piscopo AORN A. Cardarelli, Napoli, G. Annuzzi, L. Bozzetto / A. Franzese, P. Buono / S. Turco, AA Turco AOU Università Federico II, F. Prisco, Seconda Università di Napoli, M. Trovati, P. Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S. Costa, M. Dal Pos Università degli Studi di Padova, V. Provenzano, L. Strazzera Ospedale Civico di Partitico, Palermo, G. Ridola Poliambulatorio Oreto Guadagna, E. Torlone, M. Orsini Federici Università degli Studi di Perugia, A. Bertolotto, M. Aragona AO Universitaria Pisana, Pisa, P. Di Bartolo, F. Pellicano AUSL Provincia di Ravenna, V. Manicardi, M. Michelini Ospedale di Montecchio, Reggio Emilia, M. Parenti, AC Babini Ospedale degli Infermi, Rimini, P. Borboni, A. Di Flaviani / ML Manca Bitti, S. Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A. Clementi, C. Tubili – AO San Camillo Forlanini, C. Suraci, S. Carletti Ospedale Sandro Pertini, ASL RMB, A. Moretti, M. Maiello F. Leonetti, VC Iannucci N. Sulli, B. Shashaj Università La Sapienza, Policlinico Umberto I, D. Fava, F. Massimiani AO S. Giovanni Addolorata, P. Pozzilli, S. Manfrini Università Campus Bio Medico, S. Manfrini, C. Landi ASUR Marche, Zona Territoriale n. 4, Senigallia, I. Tanganelli Università degli Studi di Siena, G. Grassi, M. Tomelini ASO San Giovanni Battista di Torino, R. De Luca, L. Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R. Candido, E. Manca ASS 1 Triestina, Trieste, L. Tonutti, C. Noacco AO Universitaria, Udine, I. Franzetti, P. Marnini AO Universitaria, Varese, IAFUSCO, Dario, Nicolucci, A, Maione, A, Franciosi, M, Amoretti, R, Busetto, R, Capani, F, Bruttomesso, D, Di Bartolo, P, Girelli, A, Leonetti, F, Morviducci, L, Ponzi, P, VitacolonnaE on behalf of the EQuality Study Group:LV, Cassano, N., Tota Ospedale Generale Regionale Miulli, Acquaviva delle, Fonti, V., Cherubini, A., Iannilli Università Politecnica di Ancona, AO G., Salesi, Ancona, A., Corsi, P., Ponzani UOC Genova Ponente, SO La, Colletta, Arenzano, V., Montani, P., Di Berardino PO di Atri, M., Velussi Casa di Cura Pineta del Carso, Aurisina, F., Giorgino, V., Gigantelli Università degli Studi di Bari, G., Beltramello, A., Pianta CAD Bassano Bassano del Grappa, R., Trevisan, G., Lepore Ospedali Riuniti di Bergamo, G., Forlani, G., Marchesini Università degli Studi di Bologna, D., Crazzolara, M., Marchesi Ospedale di Bolzano, E., Zarra, B., Agosti Spedali Civili di Brescia, G., Careddu Ospedale SS Prosperie Caterina, Camogli, L., Tomaselli, R., Vigneri Ospedale Garibaldi Nesima, Catania, M., Agrusta, V., Di Blasi PO di Cava dei Tirreni, S., Tumini, MT Anzellotti / E., Vitacolonna, F. Capani Università G., D’Annunzio, Chieti e., Pescara, P., Ruggeri Azienda Istituti Ospedalieri, Cremona, P., Foglini, M. Rossana Ospedale A., Murri, Fermo, S., Toni, MF Reali AO Universitaria degli Studi, Meyer, Firenze, M., Nizzoli, S., Aquati Ospedale Morgagni, Forlì, G., D'Annunzio, N. Minuto Istituto G., Gaslini, Genova, L., Cataldi, C., Bordone AO Università San Martino, R., Iannarelli, F., Sciarretta PO San Salvatore, L'Aquila, M., Tagliaferri, MA Lezzi Ospedale G., Vietri, Larino, L., Sciangula, A., Ciucci Ospedale di Mariano Comense, M., Bonomo, E., Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G., Mariani, P., Colapinto AO San Carlo Borromeo, G., Testori, P. Rampini AO Fatebenefratelli e., Oftalmico, R., Bonfanti, F. Meschi / G., Galimberti, A., Laurenzi Istituto Scientifico Ospedale San Raffaele, A., Veronelli, C., Mauri Ospedale San Paolo, C., Tortul, AM Cernigoi Ospedale San, Paolo, Monfalcone, ME De, Feo, M. Piscopo AORN A., Cardarelli, Napoli, G., Annuzzi, L. Bozzetto / A., Franzese, P. Buono / S., Turco, AA Turco AOU Università Federico, Ii, F., Prisco, Iafusco, Dario, Seconda Università di, Napoli, M., Trovati, P., Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S., Costa, M., Dal Pos Università degli Studi di Padova, V., Provenzano, L., Strazzera Ospedale Civico di Partitico, Palermo, G., Ridola Poliambulatorio Oreto Guadagna, E., Torlone, M., Orsini Federici Università degli Studi di Perugia, A., Bertolotto, M., Aragona AO Universitaria Pisana, Pisa, P., Di Bartolo, F., Pellicano AUSL Provincia di Ravenna, V., Manicardi, M., Michelini Ospedale di Montecchio, Reggio, Emilia, M., Parenti, AC Babini Ospedale degli, Infermi, Rimini, P., Borboni, A., Di Flaviani / ML Manca Bitti, S., Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A., Clementi, C., Tubili – AO San Camillo Forlanini, C., Suraci, S., Carletti Ospedale Sandro Pertini, Asl, Rmb, A., Moretti, M. Maiello F., Leonetti, VC Iannucci N., Sulli, B., Shashaj Università La Sapienza, Policlinico Umberto, I, D., Fava, F. Massimiani AO S., Giovanni Addolorata, P., Pozzilli, S., Manfrini Università Campus Bio Medico, S., Manfrini, C., Landi ASUR Marche, Zona Territoriale n., 4, Senigallia, I., Tanganelli Università degli Studi di Siena, G., Grassi, M., Tomelini ASO San Giovanni Battista di Torino, R., De Luca, L., Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R., Candido, E., Manca ASS 1 Triestina, Trieste, L., Tonutti, C., Noacco AO Universitaria, Udine, I., Franzetti, P., Marnini AO Universitaria, and Varese
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- 2007
6. Prevalence of peripheral artery disease by abnormal ankle-brachial index in atrial fibrillation: implications for risk and therapy
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Violi, Francesco, Daví, Giovanni, Hiatt, William, Lip, Gregory Y. H., Corazza, Gino R., Perticone, Francesco, Proietti, Marco, Pignatelli, Pasquale, Vestri, Anna R., Basili, Stefania, Desideri, ARAPACIS Study Investigators Alessandri Cesare (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, G., Sapienza-Università di Roma), Serviddio Gaetano (Department of Medical and Surgical Sciences, University of Foggia), Fascetti Stefano (UOC Medicina Generale, USL 12 Viareggio, Toscana), Serra, Pietro, Palange Paolo(UOC Medicina Interna, I, Dipartimento di Sanità Pubblica, e Malattie Infettive, Greco, Eleonora, Bruno Graziella (Medicina, 3, Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, Maurizio, Giammanco Antonina (Dipartimento Biomedico di Medicina Interna, e Specialistica (DIBIMIS), Università di Palermo), Sposito Pietro (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro Raimondo, De Gennaro Leonardo(Istituto di Medicina Interna, e Geriatria, Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Loria, Paola, Pellegrini Elisa(Medicina Interna ad Indirizzo Metabolico, – NOCSAE Baggiovara, Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics, Università degli Studi di Modena, e Reggio Emilia), Cominacini, Luciano, Mozzini Chiara (Dipartimento di Medicina, Sezione di Medicina Interna, D, Università di Verona), Sprovieri, Mario, Spagnuolo Vitaliano (UOC Medicina d'Urgenza, e PS, Stabilimento Ospedaliero dell'Annunziata, Cosenza), Cerqua Giannantonio (UOC Medicina Interna per l'Urgenza, S Giovanni Addolorata, Ao, Cerasola Giovanni, Mulé Giuseppe (Università degli Studi di Palermo), Barbagallo, Mario, Lo Sciuto Salvatore, Monteverde Alfredo(UOC di Geriatria, e Lungodegenza, Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, Antonino, Lo Gullo Alberto (UOC Medicina Interna, Università di Messina), Malatino, Lorenzo, Cilia Chiara (Clinica Medica, Ospedale, Cannizzaro, Università degli Studi di Catania), Licata, Giuseppe, Tuttolomondo, Antonino, Conigliaro Roberta (UOC Medicina Interna, e Cardioangiologia, Dipartimento Biomedico di Medicina Interna, e Specialistica, Università degli Studi di Palermo), Pinto, Antonio, Di Raimondo Domenico (UOC Medicina Vascolare, Dipartimento Biomedico di Medicina Interna e Specialistica, (Di. Bi. M. I. S. )., Signorelli, Santo, Anzaldi Massimiliano (Dipartimento di Medicina Interna, e Patologia, Università degli studi di Catania), De Palma Daniela, Galderisi, Maurizio, Cudemo Giuseppe (Dipartimento di Medicina Clinica, e Sperimentale, AUP Federico II di Napoli), Galletti, Ferruccio, Fazio Valeria(Dipartimento di Medicina Clinica, e Chirurgia, Università di Napoli Federico II), De Luca Nicola, Meccariello Alfonso (Centro Ipertensione, AUO Federico II, Napoli), Caputo, Dario, De Donato Maria Teresa (UO Medicina Interna, Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, Arcangelo, Bresciani Alessandro (Divisione di Medicina Interna, Cardarelli, Osp. A., Giunta, Riccardo, Cimini Claudia (V Divisione Medicina Interna ed Immunoallergologia, Policlinico, Sun, Utili, Riccardo, Durante Mangoni Emanuele, Agrusta Federica (Medicina Infettivologica, e dei Trapianti, Monaldi, Ao, Sun, Napoli), Adinolfi Luigi, E., Sellitto, Cristiana, Restivo Luciano (Medicina Interna, Seconda Università di Napoli, Ospedale di Marcianise), Bellis, Paolo, Tirelli Paolo (UOC Medicina Interna e di Urgenza, e Pronto Soccorso, del Loreto Nuovo, P. O. S. M., Loreto, Mare), Sacerdoti, David, Pesce Paola (Clinica Medica, 5, Dipartimento di Medicina DIMED, Università degli Studi di Padova), Vanni Dino (UO Medicina Interna Arezzo, Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, Luigi, Ciacciarelli, Marco, Pacelli Antonio (Department of Medico-Surgical Sciences and Biotechnology, Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli Alberto (Sezione Cardiologia, Dipartimento di Medicina Interna, e Malattie Metaboliche, Università di Siena, Ospedale Le Scotte), Cacciafesta, Mauro, Gueli Nicola (UOC di Medicina Geriatrica, e Riabilitazione, Sapienza- Università di Roma, Capeci, William, Tarquinio, Nicola, Pellegrini Francesco (UO Medicina 'SS Benvenuto, e Rocco', Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), Vincentelli Giovanni Maria (UOS Breve Osservazione, Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, Ferdinando, Santini Claudio (UOC Medicina Interna, Ospedale, Vannini, Letizia, Claudio, Petramala, Luigi, Zinnamosca Laura (UOD Ipertensione Secondaria, Dipartimento di Medicina Interna, e Specialità Mediche, Cilli, Mirella, Savoriti Claudio (UOC Medicina Interna F, e Malattie Metaboliche Dell'osso-Direttore Minisola Salvatore, Falaschi, Paolo, Martocchia, Antonio, Stefanelli Manuela (UO Geriatria, Andrea, Azienda Ospedaliera S., Facoltà di Medicina, e Psicologia, Marigliano, Vincenzo, Lo Iacono Cristina, Brusco Simona (Centro di Ricerca Interdipartimentale Scienze dell’Invecchiamento, Bertazzoni, Giuliano, Attalla El Halabieh Elias (UOC Medicina d’Urgenza, Dipartimento di Emergenza ed Accettazione, Paradiso, Michele, Lizzi Eugenio Maria, Timmi Stefano (Ospedale San Giovanni Battista, Ordine di Malta, Battisti Paola (Medicina Interna II, Ospedale San Giovanni-Addolorata, Cerci Sabina (UOC Medicina Interna, Ospedali Riuniti Frascati, Marino), Ciavolella Massimo (UOC Cardiologia-UTIC, Ospedale di Frascati, Di Veroli Claudio (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche, e Renali, Casa di Cura 'San Domenico', Malci, Francesco, De Ciocchis Anita (UOC di Medicina Interna, Ospedale, ASL Roma, G, Subiaco), Abate, Damiano(Az., Castellino, Pietro, Curto, Irene, Vecchio Claudia (UOC Medicina Interna, Dipartimento di Scienze Mediche, e Pediatriche, Mannarino, Elmo, Pasqualini, Leonella, Fattori Chiara (Medicina Interna, Angiologia, e Malattie da Arteriosclerosi, Università degli Studi di Perugia), Pende, Aldo, Denegri, Andre, Artom Nathan (Clinica di Medicina Interna, 1, Università di Genova, San Martino - IST, IRCCS Az. Osp. Univ., Genova), Ricchio, Roberto, Fimognari Filippo Luca (UOC Geriatria, Azienda Ospedaliera di Cosenza, Alletto, Maurizio, Messina Simona (Unità Operativa di Medicina, Elia, Ospedale S., Caltanissetta), Sesti, Giorgio, Arturi, Franco, Grembiale Alessandro (Università degli Studi, UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino Paola Elisa, Carullo Giuseppe (Cattedra di Medicina Interna, UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, Pierluigi, Spagnuolo Vitaliano (UOC Medicina Interna, e Reumatologia, Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), Battaglia Giuseppe (UO Lungodegenza, Serra San Bruno, S. O., ASP Vibo Valentia), Vidili, Gianpaolo, Atzori, Sebastiana, Delitala Giuseppe (Clinica Medica, Dipartimento di Medicina Clinica, e Sperimentale, Aou, Sassari), Davì, Giovanni, Angelucci, Ermanno, Sestili Simona (UOC di Clinica Medica, PO Clinicizzato di Chieti), Traisci, Giancarlo, De Feudis Lucrezia (UOC Medicina Interna, 2, PO di Pescara), Di Michele Dario, Fava Alessandra (UOC Medicina Interna, Asl, Teramo), Balsano, Clara, De Ciantis Pierpaolo (Dipartimento di Medicina Interna, e Sanità Pubblica, Università, dell'Aquila), Desideri, Giovambattista, Camerota Antonio (UOC Geriatria, e Lungodegenza Geriatrica, Dipartimento Medico ORM, Avezzano), Po, Migliacci, Rino, Medicina Interna, Porciello Giovanni (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), Mezzetti Matteo (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, Paolo, Vedovati, Cristina, Fierro Tiziana (Dipartimento di Medicina Interna, Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), Puccetti, Luca, Scarpini Francesca (Centro Aterosclerosi, Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, Marco, Mussi Chiara (UO Geriatria, Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Boddi, Maria, Savino, Andrea, Contri Silvia (Dipartimento di Area Critica Medico- Chirurgica, Università degli Studi di Firenze), Saller, Alois, Fabris Fabrizio (Clinica Medica1, Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova, Italy), Pesavento, Raffaele, Filippi, Lucia, Vedovetto Valentina (Dipartimento di Scienze Cardiologiche, Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), Puato Massimo (Clinica Medica IV, Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, Fabrizio, Treleani Martina (UOA Medicina, Policlinico, Universitario, Maselli, Monica, Corradin Maria Luisa, Giantin Valter (Clinica Geriatrica, Università di Padova), Semplicini Andrea (Medicina Interna, 1, Giovanni e Paolo, Ospedale SS., Venezia), Minuz, Pietro, Calabria, Stefano, Romano Simone (Sezione di Medicina Interna, C, Università di Verona, Aoui, Verona), Fantin, Francesco, Manica Angela (Dipartimento di Medicina, Sezione di Geriatria, Stockner, Ingrid, Pattis, Peter, Wiedermann), Gutmann Bernhard (Divisione di Medicina Interna-Direttore Prof. J., Ospedale centrale di Bolzano), Catena, Cristiana, Colussi GianLuca (Hypertension Unit and Division of Internal Medicine, Department of Experimental and Clinical Medical Science, University of Udine, Udine, Italy), Annoni, Giorgio, Bruni Adriana Antonella, Castagna Alberto (Clinica Geriatrica, Università degli Studi di Milano- Bicocca, Dipartimento di Scienze della Salute, AO San Gerardo, Monza), Spinelli Diana (Medicina Interna 1a, Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), Corazza Gino Roberto, Miceli, Emanuela, Padula Donatella (Clinica Medica, I, Reparto, 11, IRCCS Policlinico San Matteo di Pavia, Pavia), Schinco, Giuseppina, Spreafico Sibilla (UOC Geriatria, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), Secchi Beatrice (UOC Medicina Interna, Ospedale, Bassini, Milano), Vanoli, Massimo, Casella Gianluca (SC Medicina Interna, Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Serra Maria Grazia (UOC Medicina, Panico', Azienda Ospedaliera 'Cardinale G., Lecce), Longo, Stefania, Antonaci Salvatore (UOC Medicina Interna, Azienda Ospedaliera Policlinico, Bari), Belfiore, Anna, Giuseppe Palasciano, Frualdo Mariella (Clinica Medica 'A. Murri'-Direttore Prof., Ventrella, Francesco, Iamele Luigi (Struttura Complessa di Medicina Interna, Cerignola, Asl, Foggia), Bianco Cesare (UOC Medicina Interna, Tropea), Santovito, Donato, Mezzetti, Andrea, Cipollone Francesco (Centro di Eccellenza Europeo, e di Riferimento Regionale per l'Aterosclerosi, l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, Salvatore, Salvati Filippo (UO Medicina Interna, Ospedale di Ortona, ASL 02 Abruzzo), Rini Giovan Battista, Scozzari Francesca (UOC Medicina Interna ed Ipertensione, Dipartimento Biomedico di Medicina Interna e Specialistica (Di. Bi. M. I., S), Giaccone' di Palermo), Policlinico 'P., Muiesan Maria Lorenza, Salvetti, Massimo, Bazza Abramo (Dipartimento di Scienze Cliniche, e Sperimentali, Università di Brescia, 2° Medicina Generale Spedali Civili, Brescia), Picardi, Antonio, De Vincentis Antonio (UOC Medicina Clinica, Policlinico Universitario Campus Bio-Medico, Cosio, Paolo, Terzolo Massimo (Medicina Interna, 1, Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, Bruno, Parasporo Bruno (UO Medicina Interna, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, Luigi, Bracco, Christian, Melchio Remo (SC Medicina Interna, Croce e Carle, AO S., Cuneo), Gentili, Tamira, Salvi Aldo (Medicina Generale, - Settore Subintensivo, Azienda, Ospedaliero-Universitaria, Ancona), Nitti, Cinzia, Falsetti Lorenzo (Medicina Generale, - Settore Ordinario, Gabrielli, Armando, Paglione Ivano (Clinica Medica, Capucci, Alessandro, Brambatti, Michela, Sparagna Armando (Clinica di Cardiologia, Ospedale, Torrette, Tirotta Daniela (UO Medicina Generale IV, Ospedale, Cervesi, Cattolica), Andreozzi, Paola, Ettorre, Evaristo, Cipriani Elisa (Area Geriatria, DAI Medicina Interna, Sapienza-Università di Roma, Rossi Fanelli Fillippo, Delfino Massimo (UOC Medicina Interna, H, Immunologia, Clinica, Nutrizione, Clinica, Endocrinologia, Glorioso, Nicola, Melis, Giada, Marras, Gianfranca, Matta Michela (Ambulatorio Ipertensione Arteriosa, e Patologie Correlate, Aou, Sassari, Sassari), Sacco Andrea (UOC Medicina Interna, PO Madonna delle Grazie, Matera), Stellitano, Elio, Scordo Anna (UO Medicina, PO 'Tiberio Evoli', Melito Porto Salvo), Russo, Franco, Caruso Assunta Antonietta (UOC Medicina Generale di Rogliano, AO di Cosenza), Porreca, Ettore, Santilli, Francesca, Tana Marco (UO Medicina Interna, e Geriatria, Ospedale Clinicizzato Colle Dell'Ara, D'Annunzio, Università G., Chieti-Pescara), Ferri, Claudio, Grassi, Davide, Di Giosia Paolo (Divisione di Medicina Interna Universitaria, - Ospedale San Salvatore, Dipartimento, Mesva, Università, Dell'Aquila, L'Aquila), Portincasa Piero (Clinica Medica 'Murri', Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi Giuseppe (ASP Reggio Calabria, Saline Joniche), Giordani, Sara, Stanghellini Vincenzo (Dipartimento di Scienze Mediche, e Chirurgiche, Università degli Studi di Bologna), Sabbà, Carlo, Suppressa Patrizia (UOC Geriatria e Centro di assistenza, e ricerca sovraziendale per le malattie rare, Mancuso, Giuseppe, Bartone, Mosè, Calipari Daniela (UOC Medicina Interna, Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, Giuseppe, Bellanuova Ignazio (UOC Cardiologia, e UTIC, Catania), Ferraro, Maria, Scalzo, Antonio, Marigliano Giampietro (ASP Cosenza), Cozzolino, Domenico, Lampitella, Antonio, Acri Vera (Dipartimento di Internistica Clinica, e Sperimentale, Galasso, Domenico, Mazzei, Francesca, Galasso Salvatore (RSA Madonna di Porto Gimigliano, Catanzaro), Buratti Alberto (Azienda Ospedaliera della Provincia di Pavia, UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Porta, Massimo, Brizzi Maria Felice (SC Medicina Interna 1U, Azienda, Ospedaliera, Torino), Fattorini, Annalisa, Sampietro, Francesca, D’Angelo Armando (Coagulation Service and Thrombosis Research Unit, IRCCS Ospedale San Raffaele, Pala, Marco, Fabbian, Fabio, Manfredini Roberto (UOC Clinica Medica, Anna, Azienda Ospedaliera-Universitaria S., Ferrara), Moroni, Carlo, Valente, Lucia, Lopreiato Francesco (Laboratorio di Ecocardiografia-Cardiologia Preventiva, DAI Cuore, e Grossi Vasi, Parente Fernando (UOC Medicina Interna, Granata Massimo (Immunologia Clinica, A, Moia, Marco, Braham Simon (Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, Rossi, Marco, Pesce Margherita (Dipartimento di Medicina Clinica, e Sperimentale, Università di Pisa), Gentile, Adelina, Catozzo Vania (UO Medicina, Ldp, Loreto, Ferranti, Edoardo, Soldini, Maurizio, Di Napoli Mariarosaria, Baciarello Giacinto (UOC Cardiologia Preventiva, e Riabilitativa, Rancan, Elena, Ageno, Walter, Guasti Luigina (Dipartimento di Medicina Clinica, e Sperimentale, Università, Dell'Insubria, Varese), Ciccaglioni, Antonio, Negri, Silvia, Polselli Marco (Centro Elettro-Stimolazione Cardiaca, Prisco Domenico (SOD Patologia Medica, Aou, Careggi, Firenze), Pignataro Francesca Serena, Pastori, Daniele, Ferro, Domenico, Loffredo, Lorenzo, Cangemi, Roberto, Perri, Ludovica, Polimeni, Licia, Catasca, Elisa, Raparelli, Valeria, Napoleone, Laura, Schillizzi, Marianna, Vicario, Tommasa, Russo, Roberta, Gentile Maria Cristina, Saliola, Mirella, Del Ben Maria, Angelico Francesco (I Clinica Medica, Sapienza-Università di, Roma)., Violi F, Daví G, Hiatt W, Lip GY, Corazza GR, Perticone F, Proietti M, Pignatelli P, Vestri AR, Basili S, ARAPACIS Study Investigators: […, Alessandri C, Serviddio G, Fascetti S, Serra P, Palange P, Greco E, Bruno G, Averna M, Giammanco A, Sposito P, De Cristofaro R, De Gennaro L, Loria P, Pellegrini E, Cominacini L, Mozzini C, Spovieri M, Spagnuolo V, Cerqua G, Cerasola G, Mulé G, Barbagallo M, Lo Sciuto S, Monteverde A, Saitta A, Lo Gullo A, Malatino L, Cilia C, Licata G, Tuttolomondo A, Conigliaro R, Pinto A, Di Raimondo D, Signorelli S, Anzaldi M, De Palma D, Galderisi M, Cudemo G, Galletti F, Fazio V, De Luca N, Meccariello A, Caputo D, De Donato MT, Iannuzi A, Bresciani A, Giunta R, Cimini C, Utili R, Durante M, Emanuele AF, Adinolfi LE, Cristiana S, Restivo L, Bellis P, Tirelli P, Sacerdoti D, Pesce P, Vanni D, Iuliano L, Palazzuoli A, Cacciafesta M, Gueli N, Capeci W, Tarquino N, Pellegrini F, Vincentelli GM, Ravallese F, Santini C, Letizia C, Petramala L, Zinnamosca L, Cilli M, Savoriti C, Falaschi P, Martocchia A, Stefanelli M, Marigliano V, Lo Iacono C, Brusco S, Bertazzoni G, El Halabieh Elias A, Paradiso M, Lizzi EM, Stefano T, Paola B, Cerci S, Ciavolella M, Di Veroli C, Malci F, De Ciocchis A, Abate D, Castellino P, Curto I, Vecchio C, Mannarino E, Pasqualini L, Fattori C, Pende A, Denegri A, Nathan A, Ricchio R, Fimognari FL, Alletto M, Messina S, Sesti G, Arturi F, Gembiale A, Scarpino PE, Carullo G, Pierluigi F, Battaglia G, Vadili G, Atzori S, Delitala G, Davì G, Angelucci E, Simona S, Giancarlo T, De Feudis L, Di Michele D, Fava A, Balsano C, De Ciantis P, Giovambattista D, Camerota A, Migliacci R, Porciello G, Mezzetti M, Gresele P, Vedovati C, Fierro T, Puccetti L, Scarpini F, Bertolotti M, Mussi C, Boddi M, Savino A, Contri S, Saller A, Fabris F, Pesavento R, Filippi L, Vedovetto V, Puato M, Treleani M, Maselli M, Corradin ML, Giantin V, Semplicini A, Minuz P, Calabria S, Romano S, Fantin F, Manica A, Stockner I, Pattis P, Guttman B, Catena C, Colussi GL, Annoni G, Bruni AA, Castagna A, Miceli E, Padula D, Schinco G, Spreafico S, Secchi B, Vanoli M, Casella G, Serra MG, Longo S, Antonaci S, Belfiore A, Frualdo M, Francesco V, Iamele L, Bianco C, Santovito D, Mezzetti A, Cipollone F, Nicolai S, Salvati F, Battista RG, Scozzari F, Muiesan ML, Salvetti M, Bazza A, Picardi A, De Vincentis A, Cosio P, Terzolo M, Fenoglio L, Bracco C, Melchio R, Gentili T, Salvi A, Nitti C, Falsetti L, Gabrielli A, Paglione I, Capucci A, Brambatti M, Sparagna A, Tirotta D, Andreozzi P, Ettorrre E, Cipriani E, Fanelli Fillippo R, Delfino M, Glorioso N, Melis G, Marras G, Matta M, Sacco A, Stellitano E, Scordo A, Russo F, Caruso Assunta A, Porreca E, Santilli F, Tana M, Ferri C, Grassi D, Di Giosia P, Portincasa P, Muscianisi G, Giordani S, Stanghellini V, Sabbà C, Supressa P, Mancuso G, Bartone M, Calipari D, Arcidiacono G, Bellanuova I, Ferraro M, Scalzo A, Marigliano G, Cozzolina D, Lampitella A, Acri V, Galasso D, Mazzei F, Galasso S, Buratti A, Porto M, Brizzi MF, Fattorini A, Sampietro F, D'Angelo A, Pala M, Fabbian F, Manfredini R, Moroni C, Valente L, Lopreiato F, Parente F, Granata M, Moia M, Braham S, Rossi M, Pesce M, Gentile A, Catozzzo V, Ferranti E, Soldini M, Di Napoli M, Baciarello G, Rancan E, Ageno W, Guasti L, Ciccaglioni A, Negri S, Polselli M, Prisco D, Pignataro FS, Pastori D, Ferro D, Loffredo L, Cangemi R, Perri L, Polimeni L, Catasca E, Raparelli V, Napoleone L, Schillizzi M, Vicario T, Russo R, Gentile MC, Saliola M, Del Ben M, Angelico F, Farcomeni A, Di Tanna G, Davi' G, Traisci G, Montebianco Abenavoli L, Grembiale A, Di Minno G, Durante ME, Pattoneri P, Boari B, Fabio G, Perego F, Bianchi Paola I, Angeli A, Colombo BM, Giannelli G, Vidili G, Torres D, Hijazl D, Gatta A, Mannucci Mannuccio P, Licata G., and …]
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Adult ,Male ,Risk ,therapy ,atrial fibrillation ,cardiovascular disease ,peripheral vascular disease ,Aged ,Atrial Fibrillation ,Female ,Humans ,Internal Medicine ,Italy ,Middle Aged ,Peripheral Arterial Disease ,Prevalence ,Registries ,Societies, Medical ,Ankle Brachial Index ,ATRIAL FIBRILLATION ,Cardiology and Cardiovascular Medicine ,Medical ,RISK FACTORS ,cardiovascular diseases ,Societies - Abstract
To the Editor: Nonvalvular atrial fibrillation (NVAF) is the most common sustained arrhythmia encountered in clinical practice and is associated with a 5-fold increased risk for stroke (1). Moreover, patients with NVAF often suffer from atherosclerotic complications such as acute myocardial infarction (AMI) (2). Peripheral artery disease (PAD) is an established marker of systemic atherosclerosis but its prevalence in NVAF is still unclear. We reasoned that inclusion of ankle-brachial index (ABI), which is an established tool for diagnosis of PAD (3), in the CHA2DS2-VASc (4) score would better define the prevalence of vascular disease. To address this issue, the Italian Society of Internal Medicine (SIMI) established an Italian registry documenting ABI in NVAF patients. The Atrial Fibrillation Registry for the ARAPACIS (Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study) study is an independent research project involving all Regional Councils of SIMI. The first objective of the study was to estimate the prevalence of ABI ≤0.90 in NVAF patients. Consecutive patients with NVAF referred to internal medicine wards were eligible for the enrollment. Enrollment started in October 2010 and continued until October 30, 2012. Patients were enrolled if they were 18 years or older and had a diagnosis of NVAF, recording during the qualifying admission/consultation or in the preceding 12 months, and if it was possible to obtain the ABI measurement. Exclusion criteria included the following: acquired or congenital valvular AF, active cancer, disease with life expectancy 0.90 (93% vs. 82%; p < 0.0001). Logistic regression analysis demonstrated that ABI ≤0.90 was significantly associated with a smoking habit (odds ratio [OR]: 1.99; 95% confidence interval [CI]: 1.48 to 2.66; p < 0.0001), diabetes (OR: 1.93; 95% CI: 1.51 to 2.46; p < 0.0001), age class 65 to 74 years (OR: 2.05; 95% CI: 1.40 to 3.07; p < 0.0001), age class ≥75 years (OR: 3.12; 95% CI: 2.16 to 4.61; p < 0.0001), and history of previous transient ischemic attack/stroke (OR: 1.64; 95% CI: 1.20 to 2.24; p = 0.002). Vascular disease, as assessed by the history elements of CHA2DS2VASc score, was recorded in 17.3% of patients; inclusion of ABI ≤0.90 in the definition of vascular disease yielded a total prevalence of 33%. A higher prevalence of vascular disease was detected if ABI ≤0.90 was included in the CHA2DS2VASc score (Fig. 1). CHA2DS2VASc including ABI ≤0.90 was more associated with previous stroke (43%; OR: 1.85; 95% CI: 1.41 to 2.44; p < 0.0001) compared to CHA2DS2VASc with ABI 0.91 to 1.39 (23%; OR: 1.52; 95% CI: 1.10 to 2.11; p = 0.0117). To the best of our knowledge, there is no large-scale study that specifically examined the prevalence of ABI ≤0.90 in NVAF. In our population, 21% had ABI ≤0.90 indicating that NVAF is often associated with systemic atherosclerosis. The CHADS2 has been recently refined with the CHA2DS2-VASc score, which includes vascular disease as documented by a history of AMI, symptomatic PAD, or detection of atherosclerotic plaque in the aortic arch (4). Comparison of vascular prevalence as assessed by CHA2DS2-VASc score and/or ABI ≤0.90 is of interest to define the potentially positive impact of measuring ABI in the management of NVAF patients. Inclusion of ABI ≤0.90 in the definition of vascular disease greatly increased the prevalence of vascular disease, which increased from 17.3% (based on history alone) to 33% (based on ABI) in the entire population. If ABI ≤0.90 was encompassed in the definition of vascular disease of CHA2DS2-VASc score the prevalence of vascular disease increased in every risk class. Inclusion of ABI ≤0.90 in the CHA2DS2-VASc score allowed us to better define the risk profile of NVAF patients with an up-grading of the risk score in each CHA2DS2-VASc score category. This may have important therapeutic implications if the new score could be tested prospectively, as a higher number of NVAF patients would potentially be candidates for an anticoagulant treatment by measuring ABI. A prospective study is, therefore, necessary to validate the risk score of this new definition of vascular disease. In conclusion, this study provides the first evidence that one-fifth of NVAF patients had an ABI ≤0.90, indicating that it may represent a simple and cheap method to better define the prevalence of vascular disease in NVAF.
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- 2013
7. In Cellulo Mössbauer and EPR Studies Bring New Evidence to the Long‐Standing Debate on Iron–Sulfur Cluster Binding in Human Anamorsin
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Geneviève Blondin, Martin Clémancey, Lucia Banci, Francesca Camponeschi, Simone Ciofi-Baffoni, Sara Matteucci, University of Florence, Department of Chemistry and Magnetic Resonance Center (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-University of Bologna-Partenaires INRAE, Physiochimie des Métaux (PMB), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Department of Chemistry, University of Florence, ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017), ANR-11-LABX-0003,ARCANE,Grenoble, une chimie bio-motivée(2011), Università degli Studi di Firenze = University of Florence (UniFI), and Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence (UniFI)-University of Bologna/Università di Bologna-Partenaires INRAE
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Iron-Sulfur Proteins ,anamorsin ,Protein family ,Stereochemistry ,metalloproteins ,Iron–sulfur cluster ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,010402 general chemistry ,01 natural sciences ,Catalysis ,law.invention ,03 medical and health sciences ,Spectroscopy, Mossbauer ,chemistry.chemical_compound ,in cellulo EPR spectroscopy ,law ,Mössbauer spectroscopy ,Iron-sulfur cluster binding ,Cluster (physics) ,Metalloprotein ,Humans ,in cellulo Mcssbauer spectroscopy ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Electron paramagnetic resonance ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,010405 organic chemistry ,Communication ,Electron Spin Resonance Spectroscopy ,Intracellular Signaling Peptides and Proteins ,General Medicine ,General Chemistry ,Communications ,iron-sulfur clusters ,0104 chemical sciences ,chemistry ,Iron–Sulfur Clusters ,in cellulo Mössbauer spectroscopy ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,Biogenesis ,Protein Binding - Abstract
Human anamorsin is an iron–sulfur (Fe–S)‐cluster‐binding protein acting as an electron donor in the early steps of cytosolic iron–sulfur protein biogenesis. Human anamorsin belongs to the eukaryotic CIAPIN1 protein family and contains two highly conserved cysteine‐rich motifs, each binding an Fe–S cluster. In vitro works by various groups have provided rather controversial results for the type of Fe–S clusters bound to the CIAPIN1 proteins. In order to unravel the knot on this topic, we used an in cellulo approach combining Mössbauer and EPR spectroscopies to characterize the iron–sulfur‐cluster‐bound form of human anamorsin. We found that the protein binds two [2Fe–2S] clusters at both its cysteine‐rich motifs., A combined in cellulo Mössbauer‐ and EPR‐based approach is applied to address controversial aspects of Fe–S cluster‐binding properties of human anamorsin, a protein involved in the biogenesis of cytosolic [4Fe–4S] cluster‐binding proteins. We show that human anamorsin binds two [2Fe–2S] clusters in‐cell in two highly conserved cysteine‐rich motifs typical of the eukaryotic CIAPIN1 protein family, with different electron‐spin‐relaxation properties.
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- 2021
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8. EANO guideline on the diagnosis and management of meningiomas
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Christian Mawrin, Felix Sahm, Emilie Le Rhun, Michael D. Jenkinson, Emanuel Houdart, Florence Lefranc, Michael Weller, Pantelis Stavrinou, Morten Lund-Johansen, David Nieuwenhuizen, Riccardo Soffietti, Kita Sallabanda, Giuseppe Minniti, Roland Goldbrunner, Matthias Preusser, Ghazaleh Tabatabai, Damien C. Weber, University of Zurich, Goldbrunner, Roland, INSERM, Université de Lille, University Hospital of Cologne [Cologne], Heidelberg University Hospital [Heidelberg], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] [OVGU], Paul Scherrer Institute [PSI], Medizinische Universität Wien = Medical University of Vienna, Università degli Studi di Siena = University of Siena [UNISI], Hôpital Lariboisière, University hospital of Zurich [Zurich], Università degli studi di Torino = University of Turin [UNITO], Universität Zürich [Zürich] = University of Zurich [UZH], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Paul Scherrer Institute (PSI), Università degli Studi di Siena = University of Siena (UNISI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Università degli studi di Torino = University of Turin (UNITO), and Universität Zürich [Zürich] = University of Zurich (UZH)
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Vascular Endothelial Growth Factor A ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,610 Medicine & health ,Guidelines ,meningioma ,Radiosurgery ,Meningioma ,surgery ,10180 Clinic for Neurosurgery ,Pharmacotherapy ,molecular pathology ,Meningeal Neoplasms ,medicine ,Humans ,1306 Cancer Research ,Medical diagnosis ,Aged ,neuropathology ,Molecular pathology ,business.industry ,radiosurgery ,Guideline ,medicine.disease ,Magnetic Resonance Imaging ,10040 Clinic for Neurology ,Clinical trial ,2728 Neurology (clinical) ,Oncology ,Radionuclide therapy ,2730 Oncology ,Neurology (clinical) ,Radiology ,business - Abstract
Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials have been conducted to guide clinical decision making, resulting in variations of management approaches across countries and centers. However, recent advances in molecular genetics and clinical trial results help to refine the diagnostic and therapeutic approach to meningioma. Accordingly, the European Association of Neuro-Oncology (EANO) updated its recommendations for the diagnosis and treatment of meningiomas. A provisional diagnosis of meningioma is typically made by neuroimaging, mostly magnetic resonance imaging. Such provisional diagnoses may be made incidentally. Accordingly, a significant proportion of meningiomas, notably in patients that are asymptomatic or elderly or both, may be managed by a watch-and-scan strategy. A surgical intervention with tissue, commonly with the goal of gross total resection, is required for the definitive diagnosis according to the WHO classification. A role for molecular profiling including gene panel sequencing and genomic methylation profiling is emerging. A gross total surgical resection including the involved dura is often curative. Inoperable or recurrent tumors requiring treatment can be treated with radiosurgery, if the size or the vicinity of critical structures allows that, or with fractionated radiotherapy (RT). Treatment concepts combining surgery and radiosurgery or fractionated RT are increasingly used, although there remain controversies regard timing, type, and dosing of the various RT approaches. Radionuclide therapy targeting somatostatin receptors is an experimental approach, as are all approaches of systemic pharmacotherapy. The best albeit modest results with pharmacotherapy have been obtained with bevacizumab or multikinase inhibitors targeting vascular endothelial growth factor receptor, but no standard of care systemic treatment has been yet defined.
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- 2021
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9. OPTIMAL LOCATION OF ECONOMIC ACTIVITY AND POPULATION DENSITY: THE ROLE OF THE SOCIAL WELFARE FUNCTION
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Boucekkine, Raouf, Fabbri, Giorgio, Federico, Salvatore, Gozzi, Fausto, Lhuillier, Elisabeth, Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Studies - Aix-Marseille University (IMéRA), Laboratoire d'Economie Appliquée de Grenoble (GAEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dipartimento di Economia Politica e Statistica (DEPS), Università degli Studi di Siena (UNISI), Libera Università Internazionale degli Studi Sociali Guido Carli [Roma] (LUISS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and Università degli Studi di Siena = University of Siena (UNISI)
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Spatiotemporal growth models ,JEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C61 - Optimization Techniques • Programming Models • Dynamic Analysis ,Benthamite vs Millian social welfare functions ,diffusion ,dynamic programming in infinite dimension ,JEL: R - Urban, Rural, Regional, Real Estate, and Transportation Economics/R.R1 - General Regional Economics ,imperfect altruism ,JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O4 - Economic Growth and Aggregate Productivity ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance - Abstract
In this paper, we consider a spatiotemporal growth model where a social planner chooses the optimal location of economic activity across space by maximization of a spatiotemporal utilitarian social welfare function. Space and time are continuous, and capital law of motion is a parabolic partial differential diffusion equation. The production function is AK. We generalize previous work by considering a continuum of social welfare functions ranging from Benthamite to Millian functions. Using a dynamic programming method in infinite dimension, we can identify a closed-form solution to the induced HJB equation in infinite dimension and recover the optimal control for the original spatiotemporal optimal control problem. Optimal stationary spatial distributions are also obtained analytically. We prove that the Benthamite case is the unique case for which the optimal stationary detrended consumption spatial distribution is uniform. Interestingly enough, we also find that as the social welfare function gets closer to the Millian case, the optimal spatiotemporal dynamics amplify the typical neoclassical dilution population size effect, even in the long-run.
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- 2021
10. Detection of Metabolite–Protein Interactions in Complex Biological Samples by High-Resolution Relaxometry: Toward Interactomics by NMR
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Jean-Max Tyburn, Simone Pisano, Ziqing Wang, Veronica Ghini, Philippe Pelupessy, Morgan Kazmierczak, Giacomo Parigi, Thorsten Marquardsen, Fabien Ferrage, Guillaume Bouvignies, Claudio Luchinat, Pavel Kadeřávek, Milan Zachrdla, Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence (UniFI)-University of Bologna/Università di Bologna-Partenaires INRAE, Structure et Dynamique des Biomolécules (LBM-E3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Chimie Moléculaire de Paris Centre (FR 2769), Ecole Polytechnique Fédérale de Lausanne (EPFL), Bruker BioSpin MRI GmbH [Ettlingen, Germany], Università degli Studi di Firenze = University of Florence (UniFI), Gestionnaire, HAL Sorbonne Université 5, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Département de Chimie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-University of Bologna-Partenaires INRAE, Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Département de Chimie - ENS Paris, and Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)
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Relaxometry ,Human blood ,Chemistry ,Metabolite ,High resolution ,General Chemistry ,Computational biology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Small molecule ,Catalysis ,NMR ,0104 chemical sciences ,Protein–protein interaction ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Metabolomics ,[CHIM] Chemical Sciences ,[CHIM]Chemical Sciences ,Interactomics ,Macromolecule - Abstract
International audience; Metabolomics, the systematic investigation of metabolites in biological fluids, cells or tissues, reveals essential information about metabolism and diseases. Metabolites have functional roles in myriads of biological processes, as substrates and products of enzymatic reactions, but also as cofactors and regulators of large numbers of biochemical mechanisms. These functions involve interactions of metabolites with macromolecules. Yet, methods to systematically investigate these interactions are hitherto still scarce. In particular, there is a need for techniques suited to identify and characterize weak metabolite-macromolecule interactions directly in complex media such as biological fluids. Here, we introduce a method to investigate weak interactions between metabolites and macromolecules in biological fluids. Our approach is based on high-resolution NMR relaxometry and does not require any invasive procedure or separation step. We show that we can detect interactions between small and large molecules in human blood serum and quantify the size of the complex. Our work opens the way for investigations of metabolite-(or other small molecules) protein interactions in biological fluids for interactomics or pharmaceutical applications.
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- 2021
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11. Caring about the human operator: haptic shared control for enhanced user comfort in robotic telemanipulation
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Alessio Artoni, Domenico Prattichizzo, Marco Gabiccini, Rahaf Rahal, Claudio Pacchierotti, Giulia Matarese, Paolo Robuffo Giordano, Sensor-based and interactive robotics (RAINBOW), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), University of Pisa - Università di Pisa, Università degli Studi di Siena (UNISI), Italian Institute of Technology (IIT), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Università degli Studi di Siena = University of Siena (UNISI), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)
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Male ,0209 industrial biotechnology ,Computer science ,02 engineering and technology ,Workspace ,Kinematics ,Haptics ,shared control ,Task (project management) ,User-Computer Interface ,020901 industrial engineering & automation ,Feedback, Sensory ,Human–computer interaction ,Control theory ,Humans ,Telemetry ,[INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO] ,0501 psychology and cognitive sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Man-Machine Systems ,050107 human factors ,Haptic technology ,business.industry ,05 social sciences ,Workload ,Robotics ,robotic telemanipulation ,Equipment Design ,Ergonomics ,Biomechanical Phenomena ,Computer Science Applications ,Human-Computer Interaction ,Touch Perception ,Teleoperation ,Female ,Artificial intelligence ,business - Abstract
International audience; Haptic shared control enables a human operator and an autonomous controller to share the control of a robotic system using haptic active constraints. It has been used in robotic teleoperation for different purposes, such as navigating along paths minimizing the torques requested to the manipulator or avoiding possibly dangerous areas of the workspace. However, few works have focused on using these ideas to account for the user's comfort. In this work, we present an innovative haptic-enabled shared control approach aimed at minimizing the user's workload during a teleoperated manipulation task. Using an inverse kinematic model of the human arm and the Rapid Upper Limb Assessment (RULA) metric, the proposed approach estimates the current user's comfort online. From this measure and an a priori knowledge of the task, we then generate dynamic active constraints guiding the users towards a successful completion of the task, along directions that improve their posture and increase their comfort. Studies with human subjects show the effectiveness of the proposed approach, yielding a 30% perceived reduction of the workload with respect to using standard guided human-in-the-loop teleoperation.
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- 2020
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12. Growth and agglomeration in the heterogeneous space: a generalized AK approach
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Giorgio Fabbri, Salvatore Federico, Fausto Gozzi, Raouf Boucekkine, Groupement de Recherche en Économie Quantitative d'Aix-Marseille (GREQAM), École Centrale de Marseille (ECM)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire d'Economie Appliquée de Grenoble (GAEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Dipartimento di Scienze Economiche e Aziendali, Libera Università INTERNAZIONALE DEGLI STUDI SOCIALI G. CARLI, Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Siena, Dipartimento di Economia Politica e Statistica, École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École des hautes études en sciences sociales (EHESS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Lai Tong, Charles, Libera Università Internazionale degli Studi Sociali Guido Carli [Roma] (LUISS), Università degli Studi di Siena = University of Siena (UNISI), Institute for Advanced Studies - Aix-Marseille University (IMéRA), Dipartimento di Economia e Finanza [Roma], UCL - SSH/IMMAQ/IRES - Institut de recherches économiques et sociales, Aix Marseille University - School of Economics and IMéRA, CNRS -, EHESS -, Universita degli Studi di Siena - Dipartimento di Economia Politica e Statistica, and LUISS Guido Carli - Dipartimento di Economia e Finanza
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Economics and Econometrics ,Diffusion (acoustics) ,Mathematical optimization ,Geography, Planning and Development ,Population ,0507 social and economic geography ,Growth ,cap- ital mobility ,Space (mathematics) ,Capital accumulation ,0502 economics and business ,infinite dimensional optimal control problems Journal of Economic Literature ,050207 economics ,Growth, agglomeration, heterogeneous and continuous space, capital mobility, infinite dimensional optimal control problems ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance ,education ,Mathematics ,education.field_of_study ,agglomeration ,[QFIN]Quantitative Finance [q-fin] ,infinite dimensional optimal control problems ,Economies of agglomeration ,05 social sciences ,1. No poverty ,Function (mathematics) ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,capital mobility ,heterogeneous and continuous space ,Capital (economics) ,8. Economic growth ,Homogeneous space ,050703 geography ,Agglomeration ,Capital mobility ,Heterogeneous and continuous space ,Infinite dimensional optimal control problems - Abstract
We provide an optimal growth spatio-temporal setting with capital accumulation and diffusion across space to study the link between economic growth triggered by capital spatio-temporal dynamics and agglomeration across space. The technology is AK, K being broad capital. The social welfare function is Benthamite. In sharp contrast to the related literature, which considers homogeneous space, we derive optimal location outcomes for any given space distributions for technology and population. Both the transitional spatio-temporal dynamics and the asymptotic spatial distributions are computed in closed form. Concerning the latter, we find, among other results, that: (i) due to inequality aversion, the consumption per capital distribution is much flatter than the distribution of capital per capita; (ii) endogenous spillovers inherent in capital spatio-temporal dynamics occur as capital distribution is much less concentrated than the (pre-specified) technological distribution; (iii) the distance to the center (or to the core) is an essential determinant of the shapes of the asymptotic distributions, that is relative location matters.
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- 2018
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13. Modulators of 14-3-3 protein-protein interactions
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Ylenia Cau, Loes M. Stevers, Jeremy Martin Davis, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Andrew J. Wilson, Christian Ottmann, Isabelle Landrieu, Jan Eickhoff, Richard G. Doveston, Luc Brunsveld, GGavin O'Mahony, Tomas Obsil, Anna Karawajczyk, Michael M. Hann, CNRS, Université de Lille, Eindhoven University of Technology [Eindhoven] [TU/e], Università degli Studi di Siena = University of Siena [UNISI], University of Dundee, Charles University [Prague] [CU], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, University of Leeds, GlaxoSmithKline [Stevenage, UK] [GSK], AstraZeneca, Chemical Biology, Eindhoven University of Technology [Eindhoven] (TU/e), Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, College of Life Sciences, MRC Protein Phosphorylation Unit, University of Pragues, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Universität Duisburg-Essen [Essen], UCB Pharma Slough, AstraZeneca (AstraZeneca), Technische Universiteit Eindhoven (TU/e), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Università degli Studi di Siena = University of Siena (UNISI), Charles University [Prague] (CU), Université de Lille-Centre National de la Recherche Scientifique (CNRS), School of Chemistry [Leeds], Universität Duisburg-Essen = University of Duisburg-Essen [Essen], and Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
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0301 basic medicine ,Nanotechnology ,Computational biology ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry ,Protein–protein interaction ,03 medical and health sciences ,Drug Discovery ,Animals ,Humans ,[CHIM]Chemical Sciences ,Peptides and proteins ,Monomers ,Crystal structure ,Inhibitors ,Inhibition ,14-3-3 protein ,ComputingMilieux_MISCELLANEOUS ,[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM] ,Chemistry ,Protein Stability ,Drug Discovery3003 Pharmaceutical Science ,Small molecule ,[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] ,030104 developmental biology ,14-3-3 Proteins ,Molecular Medicine ,Perspective ,Medical science ,Biologie ,Protein Binding - Abstract
International audience; Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of protein–protein interactions (PPIs) has now been widely recognized as an attractive means to therapeutically intervene in disease states. Even though this is a challenging endeavor and PPIs have long been regarded as “undruggable” targets, the last two decades have seen an increasing number of successful examples of PPI modulators, resulting in growing interest in this field. PPI modulation requires novel approaches and the integrated efforts of multiple disciplines to be a fruitful strategy. This perspective focuses on the hub-protein 14-3-3, which has several hundred identified protein interaction partners, and is therefore involved in a wide range of cellular processes and diseases. Here, we aim to provide an integrated overview of the approaches explored for the modulation of 14-3-3 PPIs and review the examples resulting from these efforts in both inhibiting and stabilizing specific 14-3-3 protein complexes by small molecules, peptide mimetics, and natural products.
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- 2018
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14. Beyond graphene oxide acidity: Novel insights into graphene related materials effects on the sexual reproduction of seed plants
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Fabio Candotto Carniel, Maurizio Prato, Mattia Bramini, Massimo Nepi, Mauro Tretiach, Emmanuel Flahaut, Cristina Martín, Lorenzo Fortuna, Giampiero Cai, Ester Vázquez, Cecilia Del Casino, Susanna Bosi, Giampiero Adami, Centre National de la Recherche Scientifique - CNRS (FRANCE), Istituto Italiano di Tecnologia - IIT (ITALY), Institut National Polytechnique de Toulouse - INPT (FRANCE), Universidad de Castilla-La Mancha - UCLM (SPAIN), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Centro de Investigación Cooperativa en Biomateriales - CIC biomaGUNE (SPAIN), Università degli Studi di Siena - UNISI (ITALY), Università degli studi di Trieste (ITALY), Centre Interuniversitaire de Recherche et d'Ingénierie des Matériaux - CIRIMAT (Toulouse, France), Università degli studi di Trieste, Università degli Studi di Siena = University of Siena (UNISI), Italian Institute of Technology (IIT), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), University of Castilla-La Mancha (UCLM), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Candotto Carniel, F., Fortuna, L., Nepi, M., Cai, G., Del Casino, C., Adami, G., Bramini, M., Bosi, S., Flahaut, E., Martin, C., Vazquez, E., Prato, M., and Tretiach, M.
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Environmental Engineering ,Cell Survival ,Matériaux ,Health, Toxicology and Mutagenesis ,Oxide ,Flowers ,Pollen Tube ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,Corylus ,law ,Pollen ,Calcium imbalance ,Ecotoxicity ,Graphene oxide ,Nanomaterials ,Phytonanotechnology ,medicine ,Environmental Chemistry ,Waste Management and Disposal ,030304 developmental biology ,0105 earth and related environmental sciences ,Calcium imbalance, Ecotoxicity, Graphene oxide, Nanomaterials, Phytonanotechnology ,0303 health sciences ,Graphene ,Chemistry ,Reproduction ,food and beverages ,Hydrogen-Ion Concentration ,Nanomaterial ,Pollution ,Sexual reproduction ,Horticulture ,Germination ,Pollen tube ,Calcium ,Graphite ,[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology ,Reactive Oxygen Species - Abstract
International audience; Graphene related materials (GRMs) are currently being used in products and devices of everyday life and this strongly increases the possibility of their ultimate release into the environment as waste items. GRMs have several effects on plants, and graphene oxide (GO) in particular, can affect pollen germination and tube growth due to its acidic properties. Despite the socio-economic importance of sexual reproduction in seed plants, the effect of GRMs on this process is still largely unknown. Here, Corylus avellana L. (common Hazel) pollen was germinated in-vitro with and without 1−100 μg mL−1 few-layer graphene (FLG), GO and reduced GO (rGO) to identify GRMs effects alternative to the acidification damage caused by GO. At 100 μg mL−1 both FLG and GO decreased pollen germination, however only GO negatively affected pollen tube growth. Furthermore, GO adsorbed about 10 % of the initial Ca2+ from germination media accounting for a further decrease in germination of 13 % at the pH created by GO. In addition, both FLG and GO altered the normal tip-focused reactive oxygen species (ROS) distribution along the pollen tube. The results provided here help to understand GRMs effect on the sexual reproduction of seed plants and to address future in-vivo studies.
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- 2019
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15. Characteristics of the Sahara as a meteorite recovery surface
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Svend Buhl, Hasnaa Chennaoui Aoudjehane, Pierre Rochette, Néjia Laridhi Ouazaa, Jérôme Gattacceca, Luigi Folco, A. J. Timothy Jull, M. Aboulahris, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), University of Arizona, Université de Tunis El Manar (UTM), Museo Nazionale dell'Antartide, Università degli Studi di Siena = University of Siena (UNISI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Université Tunis El Manar (UTM), Università degli Studi di Siena (UNISI), and Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
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FLUX ,BULLETIN ,Geochemistry ,North africa ,Weathering ,010502 geochemistry & geophysics ,01 natural sciences ,CLASSIFICATION ,Chondrite ,SEARCH ,0103 physical sciences ,Brachinite ,010303 astronomy & astrophysics ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,ATACAMA DESERT ,C-14 TERRESTRIAL AGES ,HOT ,OMAN ,COLLECTION AREA ,ORDINARY CHONDRITES ,Geophysics ,Meteorite ,13. Climate action ,Space and Planetary Science ,[SDU.OTHER]Sciences of the Universe [physics]/Other ,Geology ,Systematic search - Abstract
International audience; We describe the geological, geomorphological, and paleoclimatic setting of the Sahara of North Africa in particular, focused on the main meteorite dense collection areas (DCA; Morocco, Algeria, Tunisia, and Libya). We report on the outcome of several meteorite recovery field expeditions in Morocco and Tunisia since 2008, by car and by foot, that applied systematic search methods. The number of meteorites collected is 41 ordinary chondrites and one brachinite. The statistics of unpaired ordinary chondrites indicates that H chondrites are more abundant (21) than L chondrites (12), while LL chondrites are rare (2). Our meteorite density estimates for Tunisia and Morocco are in the order of magnitude of 1 met km(-2). An estimate of the total maximum number of meteorites that could be recovered from the Sahara is 780,000 meteorites. We selected 23 meteorites from Aridal, Bou Kra, Bir Zar, and Tieret DCAs for C-14 dating. The results show a wide range of terrestrial ages from 0.4 to more than 40 kyr with a majority of meteorites showing ages between 0.4 and 20 kyr. The weathering degree of these meteorites is ranges from minor (W1) to strong (W4). The highest weathering grades result from repeated oscillations between high and low humidity in the Sahara. However, there appears to be no correlation between weathering grade and terrestrial age of meteorites.
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- 2019
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16. A spatiotemporal framework for the analytical study of optimal growth under transboundary pollution
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Boucekkine, Raouf, Fabbri, Giorgio, Federico, Salvatore, Gozzi, Fausto, Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Studies - Aix-Marseille University (IMéRA), Laboratoire d'Economie Appliquée de Grenoble (GAEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Dipartimento di Economia Politica e Statistica (DEPS), Università degli Studi di Siena (UNISI), Libera Università Internazionale degli Studi Sociali Guido Carli [Roma] (LUISS), École des hautes études en sciences sociales (EHESS)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Siena = University of Siena (UNISI), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Lhuillier, Elisabeth
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JEL: R - Urban, Rural, Regional, Real Estate, and Transportation Economics/R.R1 - General Regional Economics/R.R1.R12 - Size and Spatial Distributions of Regional Economic Activity ,JEL: Q - Agricultural and Natural Resource Economics • Environmental and Ecological Economics/Q.Q5 - Environmental Economics/Q.Q5.Q53 - Air Pollution • Water Pollution • Noise • Hazardous Waste • Solid Waste • Recycling ,JEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C61 - Optimization Techniques • Programming Models • Dynamic Analysis ,transboundary pollution ,infinite dimensional optimal control ,JEL: R - Urban, Rural, Regional, Real Estate, and Transportation Economics/R.R1 - General Regional Economics/R.R1.R11 - Regional Economic Activity: Growth, Development, Environmental Issues, and Changes ,JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O4 - Economic Growth and Aggregate Productivity/O.O4.O41 - One, Two, and Multisector Growth Models ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,optimal growth ,spatiotemporal modelling - Abstract
We construct a spatiotemporal frame for the study of optimal growth under transboundary pollution. Space is continuous and polluting emissions originate in the intensity of use of the production input. Pollution flows across locations following a diffusion process. The objective functional of the economy is to set the optimal production policy over time and space to maximize welfare from consumption, taking into account a negative local pollution externality and the diffusive nature of pollution. Our framework allows for space and time dependent preferences and productivity, and does not restrict diffusion speed to be space-independent. This provides a comprehensive setting to analyze pollution diffusion with a close account of geographic heterogeneity. The involved optimization problem is infinite-dimensional. We propose an alternative method for an analytical characterization of the optimal paths and the asymptotic spatial distributions. The method builds on a deep economic concept of pollution spatiotemporal welfare effect, which makes it definitely useful for economic analysis.
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- 2019
17. Quasi-Optical Excitation of Modulated Metasurface Antennas
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David Gonzalez-Ovejero, Jorge Ruiz-Garcia, Mauro Ettorre, Adham Mahmoud, Marco Faenzi, P. Pouliguen, Ronan Sauleau, Patrick Potier, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut d'Electronique et de Télécommunications de Rennes (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Siena (UNISI), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Lyon (ENVL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), DGA Maîtrise de l'information (DGA.MI), Direction générale de l'Armement (DGA), Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-SUPELEC-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'Électronique et des Technologies du numéRique (IETR), Nantes Université (NU)-Université de Rennes 1 (UR1), Università degli Studi di Siena = University of Siena (UNISI), Centre National de la Recherche Scientifique (CNRS)-Ecole Supérieure d'Electricité - SUPELEC (FRANCE)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Supérieure d'Electricité - SUPELEC (FRANCE)-Centre National de la Recherche Scientifique (CNRS)
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Physics ,business.industry ,Aperture ,Astrophysics::Instrumentation and Methods for Astrophysics ,020206 networking & telecommunications ,Tapering ,02 engineering and technology ,01 natural sciences ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,Cardinal point ,Optics ,Amplitude ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Physics::Accelerator Physics ,Antenna (radio) ,010306 general physics ,business ,Excitation ,ComputingMilieux_MISCELLANEOUS - Abstract
We present a new architecture for modulated metasurface (MTS) antennas with rectangular shape and fed by means of a pillbox-type quasi-optical beamformer. Two design examples were numerically simulated, the first one consists of a linearly-polarized antenna with amplitude tapering to increase the aperture efficiency, while the second one provides a circularly-polarized pencil beam. We show that the proposed structure is able to provide high aperture efficiencies similar to those already demonstrated with circular apertures. Moreover, the use of multiple sources in the focal plane allows us to introduce multi-beam capabilities.
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- 2019
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18. Spatial analysis of hydraulic conductivity for slope deposits at catchment scale in Northern Tuscany, Italy
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Pio Papasidero, Michele, Disperati, Leonardo, Vinches, Marc, Ayral, Pierre-Alain, Johannet, Anne, Department of Physical Sciences, Earth and Environment [Siena] (DSFTA), Università degli Studi di Siena (UNISI), Laboratoire de Génie de l'Environnement Industriel (LGEI), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Università degli Studi di Siena = University of Siena (UNISI), and IMT - Mines Alès, Administrateur
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Slope deposits, hydraulic conductivity, regionalization ,[SDE] Environmental Sciences ,regionalization ,[SDE]Environmental Sciences ,Slope deposits ,hydraulic conductivity ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2019
19. The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma
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Franco Roviello, Paul M. Schneider, Fátima Carneiro, Christoph Röcken, William H. Allum, Florian Lordick, Marcel Verheij, Guillaume Piessen, Antoine Adenis, Manfred P. Lutz, Heike I. Grabsch, Elizabeth C Smyth, Michel Ducreux, Stefan Seewald, Pierre Laurent-Puig, John Zalcberg, Anna Dorothea Wagner, Markus Möhler, Angela Riddell, Eric Van Cutsem, Florian Otto, Daniela Aust, Stefan Mönig, Radka Obermannova, Monash University [Melbourne], Institut Gustave Roussy (IGR), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Royal Marsden NHS Foundation Trust, Cambridge University Hospitals - NHS (CUH), University of Cambridge [UK] (CAM), Institut für Pathologie [Berlin], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto = University of Porto, Faculdade de Medicina da Universidade do Porto (FMUP), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Université Paris Descartes - Paris 5 (UPD5), University Hospital Leipzig, University Medical Center [Mainz], Hôpitaux Universitaires de Genève (HUG), Masaryk Memorial Cancer Institute (MMCI), Université de Lille, The Royal Marsden, Christian-Albrechts University of Kiel, Università degli Studi di Siena = University of Siena (UNISI), University Hospital Gasthuisberg [Leuven], Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Brustzentrum Kantonsspital St. Gallen, Universidade do Porto, Masaryk Memorial Cancer Institute (RECAMO), University Hospital Gasthuisberg, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Universidade do Porto [Porto], Faculdade de Medicina da Universidade do Porto [Porto] (FMUP), Maastricht University Medical Center (MUMC), and Università degli Studi di Siena (UNISI)
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0301 basic medicine ,Endoscopic ultrasound ,Cancer Research ,medicine.medical_specialty ,Esophageal Neoplasms ,Adenocarcinoma of the gastro-oesophageal junction ,Expert consensus ,Gastric cancer ,Multimodal treatment ,SURGERY ,[SDV]Life Sciences [q-bio] ,Adenocarcinoma ,DECISION-MAKING ,DIAGNOSIS ,CHEMORADIOTHERAPY ,03 medical and health sciences ,0302 clinical medicine ,Stomach Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Gastrointestinal cancer ,the gastro-oesophageal junction ,medicine.diagnostic_test ,PERIOPERATIVE CHEMOTHERAPY ,GASTROESOPHAGEAL ADENOCARCINOMA ,Perioperative ,medicine.disease ,Combined Modality Therapy ,Neoadjuvant Therapy ,3. Good health ,Oxaliplatin ,PATHOLOGY ,Regimen ,030104 developmental biology ,Oncology ,Docetaxel ,Fluorouracil ,030220 oncology & carcinogenesis ,SURVIVAL ,Esophagogastric Junction ,CLINICAL-PRACTICE GUIDELINES ,Radiology ,Adenocarcinoma of ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] ,medicine.drug - Abstract
Contains fulltext : 207090.pdf (Publisher’s version ) (Closed access) Multimodal primary treatment of localised adenocarcinoma of the stomach, the oesophagus and the oesophagogastric junction (AEG) was reviewed by a multidisciplinary expert panel in a moderated consensus session. Here, we report the key points of the discussion and the resulting recommendations. The exact definition of the tumour location and extent by white light endoscopy in conjunction with computed tomography scans is the backbone for any treatment decision. Their value is limited with respect to the infiltration depth, lymph node involvement and peritoneal involvement. Additional endoscopic ultrasound was recommended mainly for tumours of the lower oesophagogastric junction (i.e. AEG type II and III according to Siewert) and in early cancers before endoscopic resection. Laparoscopy to diagnose peritoneal involvement was thought to be necessary before the start of neoadjuvant treatment in all gastric cancers and in AEG type II and III. In general, perioperative multimodal treatment was suggested for all locally advanced oesophageal tumours and for gastric cancers with a clinical stage above T1N0. There was consensus that the combination of fluorouracil, folinic acid, oxaliplatin and docetaxel is now a new standard chemotherapy (CTx) regimen for fit patients. In contrast, the optimal choice of perioperative CTx versus neoadjuvant radiochemotherapy (neoRCTx), especially for AEG, was identified as an open question. Expert treatment recommendations depend on the tumour location, biology, the risk of incomplete (R1) resection, response to treatment, local or systemic recurrence risks, the predicted perioperative morbidity and patients' comorbidities. In summary, any treatment decision requires an interdisciplinary discussion in a comprehensive multidisciplinary setting.
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- 2019
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20. PhenoMeNal: processing and analysis of metabolomics data in the cloud
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Daniel J. Jacob, Noureddin Sadawi, Kristian Peters, Reza M. Salek, Christoph Ruttkies, Kim Kultima, Susanna-Assunta Sansone, James Bradbury, Rico Rueedi, Steffen Neumann, Ralf J. M. Weber, Kenneth Haug, Sven Bergmann, Merlijn van Rijswijk, Evangelos Handakas, Marco Capuccini, Alina Peluso, Pedro de Atauri, Bita Khalili, Michelle A.C. Reed, Claire O'Donovan, Ulrich L. Günther, Namrata Kale, Philippe Rocca-Serra, Vitaly A. Selivanov, Alejandra Gonzalez-Beltran, Antonio Rosato, Massimiliano Izzo, Pablo Moreno, Pierrick Roger, Christoph Steinbeck, Etienne A. Thévenot, Luca Pireddu, Gianluigi Zanetti, Michael van Vliet, Timothy M. D. Ebbels, Fabien Jourdan, Jon Ander Novella, Anders Larsson, Robert C. Glen, Ibrahim Karaman, Jake T M Pearce, Payam Emami Khoonsari, Stephanie Herman, Marco Enrico Piras, Petr Holub, Mattia Tomasoni, Marta Cascante, Christian Ludwig, Daniel Schober, Thomas Hankemeier, David Johnson, Samuel Lampa, Ola Spjuth, Carles Foguet, Mark R. Viant, European Molecular Biology Laboratory, Imperial College Healthcare NHS Trust- BRC Funding, National Institutes of Health, Department of Stress and Developmental Biology, Leibniz Institute of Plant Biochemistry (IPB), School of Biosciences, University of Birmingham [Birmingham], Université de Lausanne (UNIL), Swiss Institute of Bioinformatics [Lausanne] (SIB), Uppsala University, Department of Pharmaceutical Biosciences, Department of Biochemistry and Molecular Biomedicine, Faculty of Science and Technology, Biochemistry and Molecular Biology, Instituto de Salud Carlos III [Madrid] (ISC), Department of Surgery & Cancer, Imperial College London, University of Cambridge [UK] (CAM), Department of Engineering Science, University of Oxford [Oxford], University of Birmingham, Leiden University, European Molecular Biology Laboratory European Bioinformatics Institute, Department of Medical Sciences, Clinical Chemistry, BBMRI-ERIC, Partenaires INRAE, Biologie du fruit et pathologie (BFP), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1, Department of Informatics and Media, Brandenburg University of Applied Sciences, Métabolisme et Xénobiotiques (ToxAlim-MeX), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), School of Public Health - Department of Epidemiology and Biostatistics, German Centre for Integrative Biodiversity Research (iDiv), CRS4 Bioinformat, Laboratoire Sciences des Données et de la Décision (LS2D), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy, Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-University of Bologna-Partenaires INRAE, Univ Florence, Dept Chem, I-50019 Florence, Italy, Brunel University London [Uxbridge], Netherlands Metabolomics Centre, Life Sciences, Institute of Analytical Chemistry, European Project: 654241,H2020,H2020-EINFRA-2014-2,PhenoMeNal(2015), Université de Lausanne = University of Lausanne (UNIL), University of Oxford, Universiteit Leiden, European research infrastructure for biobanking (BBMRI-ERIC), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB), Plateforme Bordeaux Metabolome, Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Bordeaux, MetaboHUB-MetaboHUB, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Università degli Studi di Firenze = University of Florence (UniFI), Università degli Studi di Siena = University of Siena (UNISI)-Università degli Studi di Firenze = University of Florence (UniFI)-University of Bologna/Università di Bologna-Partenaires INRAE, Glen, Robert [0000-0003-1759-2914], and Apollo - University of Cambridge Repository
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Life Sciences & Biomedicine - Other Topics ,Computer science ,Interoperability ,data analysis ,Cloud computing ,METABOLITES ,ANNOTATION ,Field (computer science) ,Workflow ,NMR ,cloud computing ,computational workflows ,e-infrastructures ,mass spectrometry ,metabolomics ,standardization ,Technical Note ,TOOL ,Orchestration (computing) ,0303 health sciences ,030302 biochemistry & molecular biology ,Small molecule ,Multidisciplinary Sciences ,Open data ,Statistical analysis ,statistics ,[SDE]Environmental Sciences ,Science & Technology - Other Topics ,User interface ,Life Sciences & Biomedicine ,INTEGRATION ,STANDARDS ,REPOSITORY ,Process (engineering) ,Phenome ,03 medical and health sciences ,Metabolomics ,[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] ,Metabolome ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,SPECTRA ,Humans ,Adaptation (computer science) ,signal processing ,Biology ,030304 developmental biology ,Reproducibility ,Science & Technology ,business.industry ,PLATFORM ,Metabolism ,MASS-SPECTROMETRY ,Omics ,Data science ,Spectrum analysis ,galaxy ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,business ,Cloud Computing ,Metabolomics/methods ,Software ,SYSTEM - Abstract
International audience; Background Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological, and many other applied biological domains. Its computationally intensive nature has driven requirements for open data formats, data repositories, and data analysis tools. However, the rapid progress has resulted in a mosaic of independent, and sometimes incompatible, analysis methods that are difficult to connect into a useful and complete data analysis solution. Findings PhenoMeNal (Phenome and Metabolome aNalysis) is an advanced and complete solution to set up Infrastructure-as-a-Service (IaaS) that brings workflow-oriented, interoperable metabolomics data analysis platforms into the cloud. PhenoMeNal seamlessly integrates a wide array of existing open-source tools that are tested and packaged as Docker containers through the project's continuous integration process and deployed based on a kubernetes orchestration framework. It also provides a number of standardized, automated, and published analysis workflows in the user interfaces Galaxy, Jupyter, Luigi, and Pachyderm. Conclusions PhenoMeNal constitutes a keystone solution in cloud e-infrastructures available for metabolomics. PhenoMeNal is a unique and complete solution for setting up cloud e-infrastructures through easy-to-use web interfaces that can be scaled to any custom public and private cloud environment. By harmonizing and automating software installation and configuration and through ready-to-use scientific workflow user interfaces, PhenoMeNal has succeeded in providing scientists with workflow-driven, reproducible, and shareable metabolomics data analysis platforms that are interfaced through standard data formats, representative datasets, versioned, and have been tested for reproducibility and interoperability. The elastic implementation of PhenoMeNal further allows easy adaptation of the infrastructure to other application areas and omics research domains.
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- 2019
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21. Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease
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Chiesa P. A., Cavedo E., Vergallo A., Lista S., Potier M. -C., Habert M. -O., Dubois B., Thiebaut de Schotten M., Hampel H., Audrain C., Auffret A., Bakardjian H., Baldacci F., Batrancourt B., Benakki I., Benali H., Bertin H., Bertrand A., Boukadida L., Cacciamani F., Causse V., Cherif Touil S., Colliot O., Dalla Barba G., Depaulis M., Dos Santos A., Dubois M., Epelbaum S., Fontaine B., Francisque H., Gagliardi G., Genin A., Genthon R., Glasman P., Gombert F., Habert M. O., Hewa H., Houot M., Jungalee N., Kas A., Kilani M., La Corte V., Le Roy F., Lehericy S., Letondor C., Levy M., Lowrey M., Ly J., Makiese O., Masetti I., Mendes A., Metzinger C., Michon A., Mochel F., Nait Arab R., Nyasse F., Perrin C., Poirier F., Poisson C., Potier M. C., Ratovohery S., Revillon M., Rojkova K., Santos-Andrade K., Schindler R., Servera M. C., Seux L., Simon V., Skovronsky D., Uspenskaya O., Vlaincu M., Aguilar L. F., Babiloni C., Benda N., Black K. L., Bokde A. L. W., Bonuccelli U., Broich K., Cacciola F., Castrillo J., Ceravolo R., Corvol J. -C., Claudio Cuello A., Cummings J. L., Depypere H., Duggento A., Durrleman S., Escott-Price V., Federoff H., Teresa Ferretti M., Fiandaca M., Frank R. A., Garaci F., Geerts H., George N., Giorgi F. S., Graziani M., Haberkamp M., Herholz K., Karran E., Kim S. H., Koronyo Y., Koronyo-Hamaoui M., Lamari F., Langevin T., Lorenceau J., Mango D., Mapstone M., Neri C., Nistico R., O'Bryant S. E., Palermo G., Perry G., Ritchie C., Rossi S., Saidi A., Santarnecchi E., Schneider L. S., Sporns O., Toschi N., Verdooner S. R., Villain N., Welikovitch L. A., Woodcock J., Younesi E., Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Treat SVD, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), sans affiliation, Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Sorbonne Université (SU), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de médecine nucléaire [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre des Maladies Cognitives et Comportementales [Paris], Fraunhofer Center for Assistive Information and Communication Solutions [Porto] (Fraunhofer AICOS), Fraunhofer (Fraunhofer-Gesellschaft), Ariana Pharmaceuticals, McGill University = Université McGill [Montréal, Canada], Universidad Autonoma de Madrid (UAM), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Pisa - Università di Pisa, Federal Institute of Drugs and Medical Devices [Bonn], Discipline of Psychiatry [Dublin], School of Medicine [Dublin], Trinity College Dublin-Trinity College Dublin, Universita degli Studi di Messina, University of Catania [Italy], University of Cambridge [UK] (CAM), Lou Ruvo Center for Brain Health [Las Vegas], Cleveland Clinic, Università degli Studi di Roma Tor Vergata [Roma], University of Pavia, Cardiff University, Universität Zürich [Zürich] = University of Zurich (UZH), University of California [Irvine] (UCI), University of California, Siemens Healthineers, Digital Services, Digital Technology and Innovation, In Silico Biosciences (ISB), Abdus Salam International Centre for Theoretical Physics [Trieste] (ICTP), University of California [San Francisco] (UCSF), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Manchester [Manchester], National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Abbvie Inc. [North Chicago], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, University of Britsh Columbia [Vancouver], Cedars-Sinai Medical Center, Functional Neuromodulation, CIBER de Enfermedades Raras (CIBERER), Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Brain Research Institute [Rome, Italy] (EBRI), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute for Aging and Alzheimer’s Disease Research [Fort Worth] (IAADR), University of North Texas Health Science Center [Fort Worth], University of Auckland [Auckland], University of Edinburgh, Università degli Studi di Siena = University of Siena (UNISI), Harvard Medical School [Boston] (HMS), Keck School of Medicine [Los Angeles], University of Southern California (USC), Indiana State University, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), NeuroVision Imaging, Fondation pour la Recherche sur Alzheimer, Center for Drug Evaluation and Research (CDER), European Society for Translational Medicine (EUSTM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service d'Explorations Fonctionnelles Neurologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de médecine nucléaire [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Fraunhofer AICOS [Porto], McGill University, Sapienza University [Rome], University of Zürich [Zürich] (UZH), Università degli Studi di Roma 'La Sapienza' [Rome], CHU Pitié-Salpêtrière [APHP], Service de neuro-radiologie [CHU Pitié-Salpêtrière], Università degli Studi di Siena (UNISI), Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Service de Médecine nucléaire [CHU Pitié-Salpétrière], Universidad Autónoma de Madrid (UAM), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Sans affiliation, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Università degli Studi di Messina = University of Messina (UniMe), Università degli Studi di Pavia = University of Pavia (UNIPV), University of California [Irvine] (UC Irvine), University of California (UC), University of California [San Francisco] (UC San Francisco), University of British Columbia [Vancouver], Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Chiesa, P. A., Cavedo, E., Vergallo, A., Lista, S., Potier, M. -C., Habert, M. -O., Dubois, B., Thiebaut de Schotten, M., Hampel, H., Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A., Boukadida, L., Cacciamani, F., Causse, V., Cherif Touil, S., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M. O., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S., Letondor, C., Levy, M., Lowrey, M., Ly, J., Makiese, O., Masetti, I., Mendes, A., Metzinger, C., Michon, A., Mochel, F., Nait Arab, R., Nyasse, F., Perrin, C., Poirier, F., Poisson, C., Potier, M. C., Ratovohery, S., Revillon, M., Rojkova, K., Santos-Andrade, K., Schindler, R., Servera, M. C., Seux, L., Simon, V., Skovronsky, D., Uspenskaya, O., Vlaincu, M., Aguilar, L. F., Babiloni, C., Benda, N., Black, K. L., Bokde, A. L. W., Bonuccelli, U., Broich, K., Cacciola, F., Castrillo, J., Ceravolo, R., Corvol, J. -C., Claudio Cuello, A., Cummings, J. L., Depypere, H., Duggento, A., Durrleman, S., Escott-Price, V., Federoff, H., Teresa Ferretti, M., Fiandaca, M., Frank, R. A., Garaci, F., Geerts, H., George, N., Giorgi, F. S., Graziani, M., Haberkamp, M., Herholz, K., Karran, E., Kim, S. H., Koronyo, Y., Koronyo-Hamaoui, M., Lamari, F., Langevin, T., Lorenceau, J., Mango, D., Mapstone, M., Neri, C., Nistico, R., O'Bryant, S. E., Palermo, G., Perry, G., Ritchie, C., Rossi, S., Saidi, A., Santarnecchi, E., Schneider, L. S., Sporns, O., Toschi, N., Verdooner, S. R., Villain, N., Welikovitch, L. A., Woodcock, J., Younesi, E., and Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
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0301 basic medicine ,Apolipoprotein E ,Epidemiology ,Brain activity and meditation ,Precuneus ,Disease ,Neuropsychological Tests ,Hippocampus ,Cohort Studies ,[SCCO]Cognitive science ,0302 clinical medicine ,Medicine ,Longitudinal Studies ,Default mode network ,ComputingMilieux_MISCELLANEOUS ,Brain Mapping ,Subjective memory complaints ,Brain functional dynamic ,Health Policy ,Precision medicine ,fMRI ,Settore BIO/14 ,Brain ,Brain functional dynamics ,Alzheimer's disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Frontal Lobe ,Psychiatry and Mental health ,medicine.anatomical_structure ,Cohort ,Biomarker (medicine) ,Female ,Amyloid ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Apolipoproteins E ,Developmental Neuroscience ,Alzheimer Disease ,Humans ,Aged ,Resting state fMRI ,business.industry ,[SCCO.NEUR]Cognitive science/Neuroscience ,030104 developmental biology ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Introduction The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E e4 (APOE e4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion For the first time, we demonstrated that the pleiotropic biological effect of the APOE e4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions.
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- 2019
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22. Dynamic slicing for Concurrent Constraint Languages
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Maurizio Gabbrielli, Catuscia Palamidessi, Moreno Falaschi, Carlos Olarte, Department of Mathematics and Computer Science / Dipartimento di Scienze Matematiche e Informatiche 'Roberto Magari' (DSMI), Università degli Studi di Siena (UNISI), Foundations of Component-based Ubiquitous Systems (FOCUS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Dipartimento di Informatica - Scienza e Ingegneria [Bologna] (DISI), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Universidade Federal do Rio Grande do Norte [Natal] (UFRN), Concurrency, Mobility and Transactions (COMETE), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'informatique de l'École polytechnique [Palaiseau] (LIX), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), STIC-AmSud project EPIC, COLCIENCIAS project CLASSIC, Università degli Studi di Siena = University of Siena (UNISI), The work of Olarte was funded by CNPq and CAPES (Brazil). The work of Palamidessi and Olarte was supported by the Regional Program STIC AMSUD 'EPIC: EPistemic Interactive Concurrency' and the project CLASSIC., Falaschi M., Gabbrielli M., Olarte C., Palamidessi C., Laboratoire d'informatique de l'École polytechnique [Palaiseau] (LIX), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
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Computer science ,Concurrency ,media_common.quotation_subject ,0102 computer and information sciences ,02 engineering and technology ,computer.software_genre ,01 natural sciences ,Theoretical Computer Science ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Concurrent Constraint Programming ,Debugging ,Program slicing ,0202 electrical engineering, electronic engineering, information engineering ,Constraint programming ,media_common ,TRACE (psycholinguistics) ,Algebra and Number Theory ,ComputingMilieux_THECOMPUTINGPROFESSION ,Programming language ,[INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO] ,Linear logic ,Constraint (information theory) ,Computational Theory and Mathematics ,010201 computation theory & mathematics ,020201 artificial intelligence & image processing ,State (computer science) ,computer ,Information Systems - Abstract
International audience; Concurrent Constraint Programming (CCP) is a declarative model for concurrency where agents interact by telling and asking constraints (pieces of information) in a shared store. Some previous works have developed (approximated) declarative debuggers for CCP languages. However, the task of debugging concurrent programs remains difficult. In this paper we define a dynamic slicer for CCP (and other language variants) and we show it to be a useful companion tool for the existing debugging techniques. We start with a partial computation (a trace) that shows the presence of bugs. Often, the quantity of information in such a trace is overwhelming, and the user gets easily lost, since she cannot focus on the sources of the bugs. Our slicer allows for marking part of the state of the computation and assists the user to eliminate most of the redundant information in order to highlight the errors. We show that this technique can be tailored to several variants of CCP, such as the timed language ntcc, linear CCP (an extension of CCP-based on linear logic where constraints can be consumed) and some extensions of CCP dealing with epistemic and spatial information. We also develop a prototypical implementation freely available for making experiments.
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- 2019
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23. Roadmap on metasurfaces
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quevedo-teruel, Oscar, Chen, Hongsheng, Díaz-Rubio, Ana, Gok, Gurkan, Grbic, Anthony, Minatti, Gabriele, Martini, Enrica, Maci, Stefano, Eleftheriades, George, Chen, Michael, Zheludev, Nikolay, Papasimakis, Nikitas, Choudhury, Sajid, Kudyshev, Zhaxylyk, Saha, Soham, Reddy, Harsha, Boltasseva, Alexandra, Shalaev, Vladimir, Kildishev, Alexander, Sievenpiper, Daniel, Caloz, Christophe, Alu, Andrea, He, Qiong, Zhou, Lei, Valerio, Guido, Rajo-Iglesias, Eva, Sipus, Zvonimir, Mesa, Francisco, Rodriguez-Berral, Raul, Medina, Francisco, Asadchy, Victor, Tretyakov, Sergei, CRAEYE, Christophe, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), KTH Royal Institute of Technology, Zhejiang University, Sergei Tretiakov Group, United Technologies Research Center Ltd., University of Michigan, University of Siena, University of Toronto, University of Southampton, Purdue University, University of California, Polytechnique Montreal, City University of New York, Fudan University, Sorbonne Université, Universidad Carlos III de Madrid, University of Zagreb, University of Sevilla, Université catholique de Louvain, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Department of Electromagnetic Engineering [Stockholm], Royal Institute of Technology [Stockholm] (KTH ), Department of Otolaryngology, central south university-Xiangya Hospital, Department of Electronics and Nanoengineering [Espoo], School of Electrical Engineering [Aalto Univ], Aalto University-Aalto University, University of Michigan [Ann Arbor], University of Michigan System, Università degli Studi di Siena = University of Siena (UNISI), École Polytechnique de Montréal (EPM), Department of Electrical and Computer Engineering - University of Texas (ECE), University of Texas at Austin [Austin], Département Traitement du Signal et des Images (TSI), Télécom ParisTech-Centre National de la Recherche Scientifique (CNRS), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique et Electromagnétisme (L2E), Sorbonne Université (SU), Electronics Technology Department, Carlos III University of Madrid, Carlos III University of Madrid, Faculty of Electrical Engineering and Computing [Zagreb] (FER), Microwaves Group, Department of Applied Physics 1, Escuela Técnica Superior de Ingenieria Informatica, Universidad de Sevilla, Universidad de Sevilla, laboratorio de catalysis, Universitat Rovira i Virgili, Université Catholique de Louvain = Catholic University of Louvain (UCL), School of Electrical Engineering [Aalto], Università degli Studi di Siena (UNISI), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Electronics Technology Department, Carlos III University of Madrid. (UC3M), and Université Catholique de Louvain (UCL)
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Telecomunicaciones ,Two-dimensional metamaterials ,BROAD-BAND ,High-rate communications ,metasurfaces, two-dimensional metamaterials, antennas, high-rate communications ,Antennas ,Metasurfaces ,Physics::Optics ,GAP WAVE-GUIDE ,ELECTROMAGNETIC-FIELDS ,EFFICIENT ANALYSIS ,FREQUENCY-SELECTIVE SURFACES ,EXPERIMENTAL VALIDATION ,[SPI]Engineering Sciences [physics] ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,RECIPROCAL RELATIONS ,REFRACTORY PLASMONICS ,[PHYS.COND]Physics [physics]/Condensed Matter [cond-mat] ,ANTENNA ,ComputingMilieux_MISCELLANEOUS ,IRREVERSIBLE-PROCESSES - Abstract
Metasurfaces are thin two-dimensional metamaterial layers that allow or inhibit the propagation of electromagnetic waves in desired directions. For example, metasurfaces have been demonstrated to produce unusual scattering properties of incident plane waves or to guide and modulate surface waves to obtain desired radiation properties. These properties have been employed, for example, to create innovative wireless receivers and transmitters. In addition, metasurfaces have recently been proposed to confine electromagnetic waves, thereby avoiding undesired leakage of energy and increasing the overall efficiency of electromagnetic instruments and devices. The main advantages of metasurfaces with respect to the existing conventional technology include their low cost, low level of absorption in comparison with bulky metamaterials, and easy integration due to their thin profile. Due to these advantages, they are promising candidates for real-world solutions to overcome the challenges posed by the next generation of transmitters and receivers of future high-rate communication systems that require highly precise and efficient antennas, sensors, active components, filters, and integrated technologies. This Roadmap is aimed at binding together the experiences of prominent researchers in the field of metasurfaces, from which explanations for the physics behind the extraordinary properties of these structures shall be provided from viewpoints of diverse theoretical backgrounds. Other goals of this endeavour are to underline the advantages and limitations of metasurfaces, as well as to lay out guidelines for their use in present and future electromagnetic devices. This Roadmap is divided into five sections: 1. Metasurface based antennas. In the last few years, metasurfaces have shown possibilities for advanced manipulations of electromagnetic waves, opening new frontiers in the design of antennas. In this section, the authors explain how metasurfaces can be employed to tailor the radiation properties of antennas, their remarkable advantages in comparison with conventional antennas, and the future challenges to be solved. 2. Optical metasurfaces. Although many of the present demonstrators operate in the microwave regime, due either to the reduced cost of manufacturing and testing or to satisfy the interest of the communications or aerospace industries, part of the potential use of metasurfaces is found in the optical regime. In this section, the authors summarize the classical applications and explain new possibilities for optical metasurfaces, such as the generation of superoscillatory fields and energy harvesters. 3. Reconfigurable and active metasurfaces. Dynamic metasurfaces are promising new platforms for 5G communications, remote sensing and radar applications. By the insertion of active elements, metasurfaces can break the fundamental limitations of passive and static systems. In this section, we have contributions that describe the challenges and potential uses of active components in metasurfaces, including new studieson non-Foster, parity-time symmetric, and non-reciprocal metasurfaces. 4. Metasurfaces with higher symmetries. Recent studies have demonstrated that the properties of metasurfaces are influenced by the symmetries of their constituent elements. Therefore, by controlling the properties of these constitutive elements and their arrangement, one can control the way in which the waves interact with the metasurface. In this section, the authors analyze the possibilities of combining more than one layer of metasurface, creating a higher symmetry, increasing the operational bandwidth of flat lenses, or producing cost-effective electromagnetic bandgaps. 5. Numerical and analytical modelling of metasurfaces. In most occasions, metasurfaces are electrically large objects, which cannot be simulated with conventional software. Modelling tools that allow the engineering of the metasurface properties to get the desired response are essential in the design of practical electromagnetic devices. This section includes the recent advances and future challenges in three groups of techniques that are broadly used to analyze and synthesize metasurfaces: circuit models, analytical solutions and computational methods.
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- 2019
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24. Geographic environmental kuznets curves: the optimal growth linear-quadratic case
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Raouf Boucekkine, Giorgio Fabbri, Fausto Gozzi, Salvatore Federico, Fabbri, Giorgio, Groupement de Recherche en Économie Quantitative d'Aix-Marseille (GREQAM), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Studies - Aix-Marseille University (IMéRA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire d'Economie Appliquée de Grenoble (GAEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Siena = University of Siena (UNISI), Dipartimento di Economia e Finanza [Roma], Libera Università Internazionale degli Studi Sociali Guido Carli [Roma] (LUISS), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Dipartimento di Scienze Economiche e Aziendali, École Centrale de Marseille (ECM)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Università degli Studi di Siena, Dipartimento di Economia Politica e Statistica, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Università degli Studi di Siena (UNISI), École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École des hautes études en sciences sociales (EHESS), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Libera Università INTERNAZIONALE DEGLI STUDI SOCIALI G. CARLI, ANR-16-CE03-0005,GREEN-Econ,Vers une économie plus verte : politiques environnementales et adaptation sociétale(2016), and Lai Tong, Charles
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Pollution ,0209 industrial biotechnology ,Mathematical optimization ,Diffusion equation ,transboundary pollution ,media_common.quotation_subject ,growth ,02 engineering and technology ,geography ,020901 industrial engineering & automation ,Quadratic equation ,Kuznets curve ,Geography ,Growth ,Infinite dimensional optimal control problems ,Transboundary pollution ,Modeling and Simulation ,JEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C61 - Optimization Techniques • Programming Models • Dynamic Analysis ,0502 economics and business ,Production (economics) ,infinite dimensional optimal control problems ,050207 economics ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance ,Productivity ,media_common ,JEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C69 - Other ,Applied Mathematics ,05 social sciences ,JEL: R - Urban, Rural, Regional, Real Estate, and Transportation Economics/R.R1 - General Regional Economics/R.R1.R11 - Regional Economic Activity: Growth, Development, Environmental Issues, and Changes ,Optimal control ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,Dynamic programming ,innite dimensional optimal control problems 1 ,13. Climate action ,8. Economic growth - Abstract
International audience; We solve a linear-quadratic model of a spatio-temporal economy using a polluting one-input technology. Space is continuous and heterogenous: locations differ in productivity, nature self-cleaning technology and environmental awareness. The unique link between locations is transboundary pollution which is modelled as a PDE diffusion equation. The spatio-temporal functional is quadratic in local consumption and linear in pollution. Using a dynamic programming method adapted to our infinite dimensional setting, we solve the associated optimal control problem in closed-form and identify the asymptotic (optimal) spatial distribution of pollution. We show that optimal emissions will decrease at given location if and only if local productivity is larger than a threshold which depends both on the local pollution absorption capacity and environmental awareness. Furthermore, we numerically explore the relationship between the spatial optimal distributions of production and (asymptotic) pollution in order to uncover possible (geographic) environmental Kuznets curve cases.
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- 2019
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25. Wideband Active Region Metasurface Antennas
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David Gonzalez-Ovejero, Stefano Maci, Marco Faenzi, Institut d'Electronique et de Télécommunications de Rennes (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Siena (UNISI), Institut d'Électronique et des Technologies du numéRique (IETR), Nantes Université (NU)-Université de Rennes 1 (UR1), Università degli Studi di Siena = University of Siena (UNISI), 4000113714/15/NL/MH/ats, European Space Agency, SAD17012, Région Bretagne, European Regional Development Fund, French Region of Brittany, Ministry of Higher Education and Research, Rennes Métropole and Conseil Départemental 35 through the CPER Project STIC & Ondes, Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)
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Wavefront ,Physics ,Frequency response ,business.industry ,Aperture ,Antenna aperture ,Bandwidth (signal processing) ,Impedance ,020206 networking & telecommunications ,02 engineering and technology ,Wavelength ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,Optics ,Bandwidth ,Broadband antennas ,Apertures ,0202 electrical engineering, electronic engineering, information engineering ,Frequency modulation ,Electrical and Electronic Engineering ,Wideband ,business - Abstract
International audience; Modulated metasurface (MTS) antennas with broadside beam rely on the interaction between a radially modulated equivalent impedance and a surface wave (SW) with cylindrical wave-front, launched by a point source. At the frequency where the SW wavelength matches the period of the impedance modulation, the-1 indexed (leaky) mode of the Floquet-mode expansion in cylindrical-coordinates provides a broadside beam. The mismatch between the SW wavelength and the period of the modulation imposes a limitation on the product bandwidth-gain. Here, we overcome this limitation by exponentially stretching the radial period of the impedance modulation. Doing so, an annular active region is generated on the antenna aperture, which moves from the antenna center to the circular rim as the frequency decreases. This mechanism enables a broadside beam over an extreme large bandwidth. We therefore extend significantly the applicability of these antennas, e.g., to requirements of 30 1.5 dB gain over 30% bandwidths. Here, an analytical formulation is proposed to treat the active region migration and edge outgoing by a Fresnel-type transition function. This function predicts in closed form the antenna bandwidth and average gain. A more accurate gain versus frequency response is also introduced by an integral formula that accounts for the frequency dependent amplitude distribution of the aperture fields. The theory is validated by full-wave simulations and by measurements of a prototype realized by sub-wavelength elliptical patches. The presented results show that these antennas can provide a performance difficult to reach by any other flat antennas based on printed technology.
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- 2019
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26. Design criteria of X-wave launchers for millimeter-wave applications
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Mauro Ettorre, Matteo Albani, Guido Valerio, Davide Comite, Walter Fuscaldo, Santi C. Pavone, Alessandro Galli, Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni [Roma] (DIET), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Dipartimento di Ingegneria dell'informazione e scienze matematiche [Siena] (DIISM), Università degli Studi di Siena = University of Siena (UNISI), Laboratoire d'Electronique et Electromagnétisme (L2E), Sorbonne Université (SU), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' [Rome], Department of Information Engineering [Sienne] (DII), Università degli Studi di Siena (UNISI), Institut d'Electronique et de Télécommunications de Rennes (IETR), Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni [Roma] ( DIET ), Dipartimento di Ingegneria dell'informazione e scienze matematiche [Siena] ( DIISM ), Università di siena 1240 [Siena], Laboratoire d'Electronique et Electromagnétisme ( L2E ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Institut d'Electronique et de Télécommunications de Rennes ( IETR ), Université de Nantes ( UN ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ), Nantes Université (NU)-Université de Rennes 1 (UR1), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)
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Computer science ,X-waves ,02 engineering and technology ,Bessel beams ,01 natural sciences ,Bessel Beams ,Localized Waves ,X-Waves ,[SPI]Engineering Sciences [physics] ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,Electrical and Electronic Engineering ,Wideband ,010306 general physics ,ComputingMilieux_MISCELLANEOUS ,Physics ,localized waves ,millimeter waves ,020208 electrical & electronic engineering ,Astrophysics::Instrumentation and Methods for Astrophysics ,020206 networking & telecommunications ,nondiffracting waves ,Large aperture ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,Extremely high frequency ,[ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism ,X-wave ,Millimeter ,Microwave - Abstract
Bessel-beam launchers are promising and established technologies for focusing applications at microwaves. Their use in time-domain leads to the definition of a new class of devices, namely, the X-wave launchers. In this work, we discuss the focusing features of such devices with a specific interest at millimeter waves. The spatial resolutions of such systems are described under a rigorous mathematical framework to derive novel operating conditions for designing X-wave launchers. These criteria might be particularly appealing for specific millimeter-wave applications. In particular, it is shown that an electrically large aperture is not strictly required, as it seemed from previous works. However, the use of an electrically small aperture would demand a considerably wideband capability. The various discussions presented here provide useful information for the design of X-wave launchers. This aspect is finally shown with reference to the practical design of two different X-wave launchers.
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- 2018
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27. Graphene oxide impairs the pollen performance of Nicotiana tabacum and Corylus avellana suggesting potential negative effects on the sexual reproduction of seed plants
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Lorenzo Fortuna, Mauro Tretiach, Emmanuel Flahaut, Fabio Candotto Carniel, Maurizio Prato, Davide Gorelli, Giampiero Cai, Massimo Nepi, Cecilia Del Casino, Università degli studi di Trieste, Università degli Studi di Siena ( UNISI ), Centre interuniversitaire de recherche et d'ingenierie des matériaux ( CIRIMAT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), CIC BiomaGUNE, Università degli Studi di Siena = University of Siena (UNISI), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), CIC BiomaGUNE [Espagne], Candotto Carniel, Fabio, Gorelli, Davide, Flahaut, Emmanuel, Fortuna, Lorenzo, Del Casino, Cecilia, Cai, Giampiero, Nepi, Massimo, Prato, Maurizio, Tretiach, Mauro, Centre National de la Recherche Scientifique - CNRS (FRANCE), Centro de Investigación Cooperativa en Biomateriales - CIC biomaGUNE (SPAIN), Università degli Studi di Siena - UNISI (ITALY), Università degli studi di Trieste (ITALY), and Centre Interuniversitaire de Recherche et d'Ingénierie des Matériaux - CIRIMAT (Toulouse, France)
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[ SDV.BV ] Life Sciences [q-bio]/Vegetal Biology ,Materials Science (miscellaneous) ,Intracellular pH ,Nicotiana tabacum ,media_common.quotation_subject ,graphene ,nanomaterials ,nanoparticles, pollen ,[ SDV.TOX.ECO ] Life Sciences [q-bio]/Toxicology/Ecotoxicology ,02 engineering and technology ,Ingénierie de l'environnement ,010501 environmental sciences ,medicine.disease_cause ,Ecotoxicologie ,01 natural sciences ,[ SDE.IE ] Environmental Sciences/Environmental Engineering ,Environmental impact ,Pollen ,medicine ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,Ecotoxicity ,0105 earth and related environmental sciences ,General Environmental Science ,media_common ,Graphene oxide ,biology ,Chemistry ,[SDE.IE]Environmental Sciences/Environmental Engineering ,Reproduction ,food and beverages ,021001 nanoscience & nanotechnology ,biology.organism_classification ,Sexual reproduction ,Horticulture ,Germination ,nanoparticles ,Pollen tube ,nanomaterial ,[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology ,Elongation ,0210 nano-technology ,Biologie végétale ,Seed plants - Abstract
The production of graphene based materials (GBMs) is steadily increasing but the effects of the possible release of GBMs in the environment are far from being understood. Graphene oxide (GO) is among the most active GBMs and it causes widely varying effects on the vegetative body of seed plants. However, nothing is known yet about its potential effects on the reproductive process. This study addresses the effects of GO on pollen germination and pollen tube elongation in the model species Nicotiana tabacum and in the non-model species Corylus avellana. In vitro germination experiments were conducted without or with GO (control and treated samples, respectively) at concentrations of 25, 50 and 100 μg mL−1. Pollen germination and tube elongation were affected at GO concentrations ≥50 μg mL−1, decreasing by 20% and 19% in N. tabacum and by 68% and 58% in C. avellana, respectively. GO did not affect the viability of N. tabacum pollen, but doubled the frequency of bent tubes. Microscopy observations of pollen tubes exposed to a cell-permeant, dual-excitation ratiometric pH indicator revealed that GO affected the intracellular pH homeostasis. Further germination experiments on C. avellana conducted by inverting the pH conditions of the control and treated (100 μg GO mL−1) samples demonstrated that the main factor influencing the pollen performance is the acidic properties of GO. This might affect the reproductive process of numerous seed plants thus being relevant from an environmental point of view.
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- 2018
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28. A switched reader complementary-loops structure for detecting LF RFID tagged pebbles
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Christophe Conessa, Marc Biancheri-Astier, Antoine Diet, Alessandro Pozzebon, K. Gbafa, M. Benamara, Gaelle Lissorgues, Marjorie Grzeskowiak, Y. Le Bihan, F. Alves, Laboratoire Génie électrique et électronique de Paris (GeePs), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Electronique, Systèmes de communication et Microsystèmes (ESYCOM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris, Università degli Studi di Siena = University of Siena (UNISI), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris, Conservatoire National des Arts et Métiers - CNAM (FRANCE), Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole de l'Innovation Technologique - ESIEE PARIS (FRANCE), Sorbonne Université (FRANCE), CentraleSupélec (FRANCE), Université Paris-Est Marne-La-Vallée - UPEM (FRANCE), Università degli Studi di Siena - UNISI (ITALY), and Université Paris-Sud 11 (FRANCE)
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Structure (mathematical logic) ,Orientation (computer vision) ,business.industry ,Computer science ,Computer Networks and Communications ,LF RFID ,020208 electrical & electronic engineering ,Complementary loops ,Mutual coupling ,Instrumentation ,Context (language use) ,Electromagnétisme ,02 engineering and technology ,Tracking (particle physics) ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,0202 electrical engineering, electronic engineering, information engineering ,Key (cryptography) ,Sensitivity (control systems) ,Instrumentation (computer programming) ,Antenna (radio) ,business ,Computer hardware - Abstract
International audience; This paper presents a reader switched complementary loops structure for pebbles RFID tracking. These so-called "smart pebbles" are tagged with LF RFID glasstags and deployed on beaches, in the context of coastal morpho-dynamics survey. At different periods, the detection of these pebbles over the beach has to be done in the minimum of time. The goal of the project LARGE is to provide a RFID reader antenna structure for reducing the time of the glasstags detection. Technical challenges are that LF glasstags detection is very sensitive to its orientation. As the prototype has to adapt to an unknown orientation and depth of the RFID tags, two key ideas are exploited in this work: (i) the use of complementary loops for reducing the orientation sensitivity and (ii) the switching in loop sizes for adapting to optimal depth of tag detection. A prototype is build and tested with a commercial RFID reader and conclusions of our measurements show that detection performances can be increased with this multiple loops and complementary loops structure.
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- 2017
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29. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)
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J. Donald Easton, Maria Aunes, Gregory W. Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R. Evans, Peter Held, Marianne Jahreskog, Jenny Jonasson, Kazuo Minematsu, Carlos A. Molina, Yongjun Wang, K.S. Lawrence Wong, S. Claiborne Johnston, Sebastiá F. Ameriso, Geoffrey Donnan, Robin Lemmens, Ayrton Massaro, Ekaterina Titianova, Michael D. Hill, Pablo Lavados, David Skoloudik, Joachim Röther, Szegedi Norbert, Giancarlo Agnelli, Natan Bornstein, Norio Tanahashi, Angel Arauz Góngora, Edwin Pretell, Maria Cristina Z. San Jose, Anna Czlonkowska, Ovidiu Bajenaru, Ludmila Stakhovskaya, Miroslav Brozman, Jong-Sung Kim, Nils Wahlgren, Patrik Michel, Tsong Hai Lee, Nijasri Charnnarong Suwanwela, Kursad Kutluk, Sergii Moskovko, Scott Kasner, Daniel Laskowitz, Wayne Clark, Huy Thang Nguyen, Sebastian Ameriso, Sandra Lepera, Marina Romano, David Paulon, Pablo Ioli, Cristina Zurru, Guadalupe Bruera, Lorena Jure, Francisco Klein, Guillermo Povedano, Christopher Levi, Thanh Phan, Romesh Markus, Craig Anderson, Arman Sabet, Stephen Davis, Andrew Lee, Timothy Kleinig, Andrew Wong, Martin Krause, Jim Jannes, Tissa Wijeratne, Dimitri Hemelsoet, André Peeters, Philippe Tack, Peter Vanacker, Patrice Laloux, William Van Landegem, Geert Vanhooren, Philippe Desfontaines, Marc Van Orshoven, Fabio Oliveira, Mauricio Friedrich, Rosane Brondani, Rubens Gagliardi, Soraia Fabio, Marianna Dracoulakis, Rodrigo Bazan, Luiz Marrone, Octavio Pontes Neto, Gisele Silva, Pedro Kowacs, Paraskeva Stamenova, Marin Daskalov, Ivan Staikov, Dimo Baldaranov, Dimitar Maslarov, Hristo Lilovski, Plamen Petkov, Neli Petrova, Radoslav Mavrov, Veska Markova, Valeria Petrova, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Veska Lekova, Dimcho Hristov, Vera Ermenkova, Lyudmil Mateev, Rumeliya Mitkova, Liybomir Haralanov, Rosen Ikonomov, Margarita Mihailova, Ivan Georgiev, Ashfaq Shuaib, Vladimir Hachinski, Jean-Martin Boulanger, Sharan Mann, Ayman Hassan, Ariane Mackey, Bijoy Menon, Jeffrey Minuk, Muzaffar Siddiqui, Marsha Eustace, Lucia Vieira, Daniel Selchen, Michel Beaudry, Grant Stotts, Angel Castro, Kristo Gasic, Rodrigo Rivas, Pablo Sanchez, Andres Roldan, Ingrid Grossmann, Christian Figueroa, Jimei Li, Xiaolin Xu, Huisheng Chen, Xiaohong Li, Yi Yang, Chunsheng Zhang, Baojun Wang, Guanglai Li, Dong Wang, Hong Lin, Yamei Tang, Anding Xu, Yanjiang Wang, Wenke Hong, Zhi Song, Xu Zhang, Xiaoping Jin, Yun Xu, Fuling Yan, Weihong Zheng, Xiaoping Wang, Qiang Dong, Zhongxin Zhao, Baorong Zhang, Wangtao Zhong, Guoqiang Wen, Jun Xu, Guozhong Li, Xueshuang Dong, Xiangyang Tian, Zhaohui Zhang, En Xu, Kaixiang Liu, Jun Chen, Ondrej Skoda, Edvard Ehler, Daniel Vaclavik, Daniel Sanak, Sylva Klimosova, Eva Vitkova, Jan Fiksa, Robert Mikulik, Jiri Neumann, Richard Plny, Didier Leys, Igor Sibon, Jean-Louis Mas, Sonia Alamowitch, Fernando Pico, Hassan Hosseini, Marie-Hélène Mahagne, Emmanuel Touze, Wilfried Vadot, Stéphane Vannier, Norbert Nighoghossian, Yves Samson, Pierre Garnier, Emmanuel Ellie, Benoît Guillon, Serge Timsit, Maurice Giroud, Frédéric Philippeau, Aude Bagan-Triquenot, Valérie Wolff, Nicolas Raposo, Michel Obadia, Severine Debiais, Jérôme Grimaud, Stéphane Illouz, Didier Smadja, Cédric Urbanczyk, Jörg Berrouschot, Christian Weimar, Georg Gahn, Hassan Soda, Sven Klimpe, Darius Nabavi, Jörg Glahn, Martin Köhrmann, Lars Krause, Christoph Terborg, Peter Urban, Thorsten Steiner, Andreas Ferbert, Rainer Dziewas, Günter Seidel, Götz Thomalla, Richard Li, Wing Chi Fong, Raymond Cheung, Norbert Szegedi, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, László Németh, Péter Diószeghy, Csaba Óváry, Attila Csányi, Levente Kerényi, Valéria Nagy, Sámuel Komoly, Dániel Bereczki, Sándor Molnár, István Kondákor, David Tanne, Guy Raphaeli, Gregory Telman, Ronen Leker, Yair Lampl, Francesco Corea, Stefano Ricci, Donata Guidetti, Giovanni Malferrari, Simona Marcheselli, Giuseppe Micieli, Andrea Zini, Vincenzo Di Lazzaro, Carlo Gandolfo, Andrea Salmaggi, Rossana Tassi, Maurizia Rasura, Giovanni Orlandi, Giancarlo Comi, Michelangelo Mancuso, Marialuisa Delodovici, Paolo Bovi, Domenico Consoli, Kimiaki Utsugisawa, Tsuneo Fujita, Hideyuki Kurihara, Chikashi Maruki, Takeshi Hayashi, Tsuneaki Ogiichi, Morio Kumagai, Katsunobu Takenaka, Kazunori Toyoda, Kazuhiro Takamatsu, Ryo Ogami, Shigenari Kin, Takeshi Aoki, Katsumi Takizawa, Shigehiro Omori, Takehiko Umezawa, Yasuyuki Toba, Yutaka Nonoyama, Hidemitsu Nakagawa, Takashi Naka, Masanori Morimoto, Shuichi Matsumoto, Tsutomu Hitotsumatsu, Tatsuya Shingaki, Satoshi Okuda, Mamoru Ota, Nobuyuki Sakai, Takeshi Yamada, Jun Niwa, Hitoshi Fujita, Akihito Moriki, Kimihiro Yoshino, Yoshihisa Fukushima, Takahisa Mori, Atsushi Sato, Yoshikazu Kusano, Michiya Kubo, Masashi Yamazaki, Takao Ooasa, Takafumi Nishizaki, Naoki Kitagawa, Masahiro Yasaka, Yasuhiro Manabe, Akira Yoshioka, Masayuki Ishihara, Takato Kagawa, Toshikazu Ichihashi, Hideki Matsuoka, Yasuhiro Ito, Masahiro Yamasaki, Hitonori Takaba, Hisatoshi Saito, Masahiro Sato, Kazumasa Fukuda, Sumio Endo, Minoru Kidooka, Toshitaka Umemura, Yuriko Kikkawa, Shuta Toru, Kentaro Yamada, Hideki Sakai, Jun Asari, Masayuki Ezura, Hisashi Nitta, Keiko Nagano, Jun Ochiai, Keiichi Sakai, Yasutaka Kobayashi, Yasuhiro Yoshii, Hirotomo Miake, Tomohiro Takita, Hidekazu Taniguchi, Kazuhiko Kuroki, Takamitsu Mizota, Kenichi Yamamoto, Hiroshi Nakane, Takeshi Iwanaga, Kei Chiba, Tetsuyuki Yoshimoto, Tsuyoshi Torii, Takeo Kitagawa, Hiroshi Takashima, Naoki Shirasaki, Makoto Dehara, Naomichi Wada, Kensuke Hamada, Noriyuki Kato, Yoshinori Go, Ichiro Izumi, Hirotomo Ninomiya, Junichiro Kumai, Yoshikazu Nakajima, Yasuhiko Kaku, Yukihiro Isayama, Masahiro Kawanishi, Shinya Noda, Kazuhide Yamamoto, Takanori Hazama, Hiroshi Takahashi, Yohei Tanaka, Takashi Hata, Kiyoshi Kazekawa, Eisuke Furui, Hideki Hondo, Nobuyuki Sato, Katsusuke Kusunoki, Kazunori Nanri, Satoshi Abe, Noboru Sasaoka, Takayuki Kuroyanagi, Hisahiko Suzuki, Kouzou Fukuyama, Kimihiro Nakahara, Fernando Gongora, Carlos Cantú Brito, Jorge Villarreal Careaga, Rosalia Vazquez Alfaro, Geronimo Aguayo Leytte, Percy Berrospi, Carlos Chavez, Liliana Rodriguez, Nilton Custodio, Cesar Castañeda, Julio Perez, Maria Cristina San Jose, Alejandro Baroque, Epifania Collantes, Abdias Aquino, Alejandro Díaz, Artemio Roxas, Johnny Lokin, Joel Advincula, Emerito Calderon, Jose Navarro, John Hiyadan, Arturo Surdilla, Danuta Ryglewicz, Grzegorz Krychowiak, Waldemar Fryze, Piotr Sobolewski, Ryszard Nowak, Urszula Fiszer, Beata Papierowska, Justyna Zielińska-Turek, Anetta Lasek-Bal, Ewa Kołodziejska, Anna Kamińska, Bożena Adamkiewicz, Andrzej Tutaj, Dorota Szkopek, Krzysztof Musiatowicz, Zbigniew Bąk, Sławomir Brzozowski, Waldemar Brola, Antoni Ferens, Marek Zalisz, Konrad Rejdak, Monika Rudzińska, Cristina Panea, Mihaela Simu, Rodica Balasa, Iulian Cuciureanu, Bogdan Popescu, Monica Sabau, Corina Roman-Filip, Leonid Pimenov, Alla Gekht, Anna Milto, Ivan Shchukin, Vladimir Parfenov, Liudmila Stakhovskaya, Mikhail Arkhipov, Nadezhda Sokolova, Enver Bogdanov, Radiy Esin, Dina Khasanova, Konstantin Golikov, Elena Melnikova, Leonid Zaslavskiy, Igor Voznyuk, Alexander Nazarov, Leila Akhmadeeva, Aida Iakupova, Nikolay Shamalov, Galina Belskaya, Svetlana Chuprina, Olga Denisova, Ekaterina Drozdova, Yuliya Karakulova, Ilya Sholomov, Nikolay Spirin, Elena Vostrikova, Elena Mordvintseva, Vera Grigoryeva, Dmitry Zateyshchikov, Vladimir Gorbachev, Zhanna Chefranova, Mikhail Dudarev, Rostislav Nilk, Alexey Rozhdestvenskiy, Ladislav Gurcik, Miloslav Dvorak, Georgi Krastev, Egon Kurca, Juraj Vyletelka, Jong Sung Kim, Hee-Joon Bae, Yong-Won Kim, Joon-Tae Kim, Jae-Kwan Cha, Hyo Suk Nam, Dae-Il Chang, Yong-Seok Lee, Kyungmi Oh, Sung-Wook Yu, Sung-Il Sohn, Jun Lee, Han Jin Cho, Eung-Gyu Kim, Joung-Ho Rha, Seo Hyun Kim, Carlos Molina Cateriano, Joaquín Serena Leal, José Vivancos Mora, Manuel Rodríguez Yañez, Jaume Roquer González, Francisco Purroy García, Meritxell Gomis Cortina, Jaime Masjuan Vallejo, Juan Arenillas Lara, Tomás Segura Martín, José Antonio Egido Herrero, Jose Ignacio Tembl Ferrairó, Jaime Gállego Culleré, Francisco Moniche Álvarez, Anna Steinberg, Margarita Callander, Ann Charlotte Laska, Lena Bokemark, Thomas Mooe, Tor-Björn Käll, Lennart Welin, Lars Sjöblom, Joakim Hambraeus, Jörg Teichert, Hans Wannberg, Johan Sanner, Bo Ramströmer, Bo Ziedén, Stefan Olsson Hau, Claes Gustafsson, Timo Kahles, Philippe Lyrer, Marcel Arnold, Martin Liesch, Friedrich Medlin, Carlo Cereda, Georg Kägi, Andreas Luft, Emmanuel Carrera, Tsong-Hai Lee, Helen L. Po, Chang-Ming Chern, Li-Ming Lien, Lung Chan, Chung-Hsiang Liu, Shey-Lin Wu, Jiann-Der Lee, Chih-Hung Chen, Huey-Juan Lin, Ruey-Tay Lin, Wei-Hsi Chen, Yu Sun, Tasanee Tantirittisak, Sombat Muengtaweepongsa, Yongchai Nilanont, Somsak Tiamkao, Chesda Udommongkol, Kanokwan Watcharasaksilp, Witoon Jantararotai, Hadiye Sirin, Birsen Ince, Talip Asil, Murat Arsava, Tulay Kurt Incesu, Hulya Tireli, Hayriye Kucukoglu, Fikri Ak, Ali Unal, Serefnur Ozturk, Nevzat Uzuner, Galyna Chmyr, Volodymyr Lebedynets, Vadym Nikonov, Lyudmyla Shulga, Volodymyr Smolanka, Marta Khavunka, Valentyna Yavorska, Nataliya Tomakh, Olexandr Kozyolkin, Galyna Litovaltseva, Maarten Lansberg, Richard Bernstein, David Brown, Jonathan Dissin, Carmelo Graffagnino, Jonathan Harris, William Hicks, Irene Katzan, Jeffrey Kramer, Joshua Willey, Scott Silliman, Sidney Starkman, David Thaler, Margaret Tremwel, Mauricio Concha, Kumar Rajamani, Bhuvaneswari Dandapani, Brian Silver, Nathan Deal, Ira Chang, Ameer Hassan, Steven Rudolph, Kenneth Fischer, Howard Kirshner, William Logan, Sidney Mallenbaum, Hebah Hefzy, Julius Latorre, Steven Levine, Anthony Ciabarra, Rima Dafer, Benjamin Anyanwu, Laurel Cherian, Spozhmy Panezai, Anna Khanna, Jodi Dodds, Michel Torbey, James Gebel, Henry Woo, David Chiu, Xiao Androulakis, William Burgin, Maria Pineda, Engin Yilmaz, Irfan Altafullah, Christine Boutwell, Salvador Cruz-Flores, Biggya Sapkota, Pierre Fayad, Michael Jacoby, Shahid Rafiq, Efrain Salgado, Eugene Lafranchise, Warren Felton, Ramesh Madhavan, Osama Zaidat, Connie Pieper, Ralph Riviello, Aaron Burnett, Michelle Fischer, Nina Gentile, Christopher Calder, Dennis Dietrich, Jonathan Cross, Larry Blankenship, Liliana Montoya, Wendell Grogan, Mark Young, Farrukh Khan, Duane Campbell, Nizar Daboul, Andrey Espinoza, Paul Cullis, Gilberto Concepcion, John Wulff, Haider Afzal, Naseem Jaffrani, William Reiter, Tamjeed Arshad, Timothy Lukovits, James Welker, Fen Lei Chang, Aamir Badruddin, Viken Babikian, Ravi Menon, James Sander, Mellanie Springer, Ashish Nanda, Luis Mas, Raj Rajan, Bruce Silverman, David Huang, David Carpenter, Joni Clark, Marilou Ching, Sunitha Santhakumar, Jeffrey Gould, Vibhav Bansal, Gabriel Vidal, Timothy Mikesell, John Brick, William French, Qaisar Shah, Christine Holmstedt, Nadir Ishag-Osman, John Kostis, Abbas Shehadeh, Pramodkumak Sethi, Asher Imam, Carl Mccomas, Duc Tran, Mehari Gebreyohanns, Brian Wiseman, Maheen Malik, Aron Schwarcz, Dorothea Altschul, John Castaldo, Amer Alshekhlee, Stephen Gancher, Nagesh Krish, Mai Nguyen-Huynh, Margaret Tremwell, Jitendra Sharma, Lance Lee, William Neil, Fazeel Siddiqui, Ali Malek, Charles Romero, Thang Nguyen Huy, Hoa Hoang, Thang Nguyen, Anh Nguyen, Hung Nguyen, Laboratoire de Recherche Vasculaire Translationnelle ( LVTS ), Université Paris 13 ( UP13 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), AstraZeneca, National Cerebral and Cardiovascular Center ( NCCC - OSAKA ), Osaka University [Osaka], Department of Neurology ( Dep Neuro - BEIJING ), Tiantan Hospital, University of Melbourne, Faculty of Mathematics and Statistics, Ton Duc Thang University, Ho Chi Minh City, Heidelberg University, Centre hospitalier de Namur, IBM Thomas J. Watson Research Center, IBM, Bulgarian Academy of Sciences, Department of Clinical Neurological Sciences [London, Canada], University of Western Ontario ( UWO ), Servicio de Neurologia ( SANTIAGO - Neurologie ), Universidad de Santiago de Chile [Santiago] ( USACH ) -Universidad del Desarrollo, Institut de Chimie de Clermont-Ferrand - Clermont Auvergne ( ICCF ), Sigma CLERMONT ( Sigma CLERMONT ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Universidad de Talca, Shanghai Second Polytechnic University, Northwest Normal University [Lanzhou], Zhongda Hospital, Southeast University [Jiangsu], Cryogenics Laboratory ( CRYOGENICS LABORATORY ), Huazhong University of Science and Technology [Wuhan] ( HUST ) -Wuhan University [China], Centre for Synthetic and Systems Biology, University of Edinburgh-School of Biological Sciences, Duke university [Durham], Fiber Glass, Glass Business and Discovery Center, PPG Industries, National University of Defense Technology [Changsha], School of Oceanography [Seattle], University of Washington [Seattle], Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guilin University of Technologie, Laboratoire de Génie Electrique et Ferroélectricité ( LGEF ), Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Université de Lyon-Institut National des Sciences Appliquées ( INSA ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Université de Bordeaux ( UB ), Service de Pédiatrie, Centre Hospitalier Universitaire de Nice ( CHU Nice ) -Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 ( UPMC ), Centre Hospitalier de Versailles ( CHV ), Service de neurologie, Hôpital Sainte-Anne, Functional Exploration of Nervous, CHU Grenoble, Service de Neurologie [Rennes], Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Français de Mécanique Avancée ( IFMA ), Neurologie - Côte Basque ( NEUROLOGIE ), Hopital, Laboratoire d'Intégration des Systèmes et des Technologies ( LIST ), Université Paris-Saclay-Direction de Recherche Technologique (CEA) ( DRT (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) ( GGB ), Institut Brestois Santé Agro Matière ( IBSAM ), Université de Brest ( UBO ) -Université de Brest ( UBO ) -EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), CIC Brest, Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Hôpital de la Cavale Blanche, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), CHU Strasbourg, Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. ( ISCT ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès ( UT2J ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès ( UT2J ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of Neurology, Asklepios Klinik Altona, Department of Neurology and Stroke Center, Universität Duisburg-Essen [Essen], Department of Neurology, University of Mainz, Vivantes Klinikum Neukölln, University of Erlangen, University Hospital Münster, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] ( UKE ), PROTOMED, Neurology Department, Ichilov Medical Center, Internal and Cardiovascular Medicine - Stroke Unit ( PERUGIA - ICM-SU ), Università degli Studi di Perugia ( UNIPG ), University Hospital San Raffaele Milan, Scientific Institute and University Ospedale San Raffaele, Dipartimento di Scienze Fisiche, della Terra e dell'Ambiente., Università degli Studi di Siena ( UNISI ), Department of Education, Yamagata University, Nippon Medical School, Catalan Institute of Ornithology (ICO), Museu de Ciències Naturals (Zoologia), Wroclaw University of Science and Technology, Department of neurology, Jagiellonian University [Krakow] ( UJ ), LInguistique et DIdactique des Langues Étrangères et Maternelles ( LIDILEM ), Université Stendhal - Grenoble 3-Université Grenoble Alpes ( UGA ), Metacohorts Consortium, GenXpro GmBH, Lausanne University Hospital, Lausanne university hospital, Northeastern University [Boston], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Cerebral and Cardiovascular Center (NCCC - OSAKA), Department of Neurology (Dep Neuro - BEIJING), Bulgarian Academy of Sciences (BAS), University of Western Ontario (UWO), Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Shanghai Polytechnic University (SSPU), Cryogenics Laboratory (CRYOGENICS LABORATORY), Huazhong University of Science and Technology [Wuhan] (HUST)-Wuhan University [China], Centre for Synthetic and Systems Biology (Ssynthsys), University of Edinburgh, Duke University [Durham], National University of Defense Technology [China], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Bordeaux (UB), Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 (UPMC), Centre Hospitalier de Versailles André Mignot (CHV), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut Français de Mécanique Avancée (IFMA), Neurologie - Côte Basque (NEUROLOGIE), Centre hospitalier universitaire de Nantes (CHU Nantes), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Internal and Cardiovascular Medicine - Stroke Unit (PERUGIA - ICM-SU), Università degli Studi di Perugia (UNIPG), Università degli Studi di Siena = University of Siena (UNISI), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurologie - Côte Basque, Centre Hospitalier de la Côte Basque (CHCB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Università degli Studi di Perugia = University of Perugia (UNIPG), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-SIGMA Clermont (SIGMA Clermont), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Jagiellonian University [Krakow] (UJ), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Weimar, Christian (Beitragende*r), and Calvez, Ghislaine
- Subjects
Male ,Risk ,Ticagrelor ,Adenosine ,[SDV]Life Sciences [q-bio] ,Population ,Medizin ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Platelet aggregation inhibitors ,Physiology (medical) ,[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology ,medicine ,Humans ,Myocardial infarction ,education ,Stroke ,ComputingMilieux_MISCELLANEOUS ,Aged ,Aspirin ,Ischemic attack ,Transient ,Female ,Ischemic Attack, Transient ,Purinergic P2Y Receptor Antagonists ,Treatment Outcome ,Cardiology and Cardiovascular Medicine ,education.field_of_study ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[ SDV ] Life Sciences [q-bio] ,Ischemic Attack ,business.industry ,medicine.disease ,Clopidogrel ,[SDV] Life Sciences [q-bio] ,Anesthesia ,Platelet aggregation inhibitor ,business ,030217 neurology & neurosurgery ,TIMI ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,medicine.drug - Abstract
Background: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes) was the first trial with ticagrelor in patients with acute ischemic stroke or transient ischemic attack in which the efficacy and safety of ticagrelor were compared with those of aspirin. The main safety objective was assessment of PLATO (Platelet Inhibition and Patient Outcomes)–defined major bleeds on treatment, with special focus on intracranial hemorrhage (ICrH). Methods: An independent adjudication committee blinded to study treatment classified bleeds according to the PLATO, TIMI (Thrombolysis in Myocardial Infarction), and GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) definitions. The definitions of ICrH and major bleeding excluded cerebral microbleeds and asymptomatic hemorrhagic transformations of cerebral infarctions so that the definitions better discriminated important events in the acute stroke population. Results: A total of 13 130 of 13 199 randomized patients received at least 1 dose of study drug and were included in the safety analysis set. PLATO major bleeds occurred in 31 patients (0.5%) on ticagrelor and 38 patients (0.6%) on aspirin (hazard ratio, 0.83; 95% confidence interval, 0.52–1.34). The most common locations of major bleeds were intracranial and gastrointestinal. ICrH was reported in 12 patients (0.2%) on ticagrelor and 18 patients (0.3%) on aspirin. Thirteen of all 30 ICrHs (4 on ticagrelor and 9 on aspirin) were hemorrhagic strokes, and 4 (2 in each group) were symptomatic hemorrhagic transformations of brain infarctions. The ICrHs were spontaneous in 6 and 13, traumatic in 3 and 3, and procedural in 3 and 2 patients on ticagrelor and aspirin, respectively. In total, 9 fatal bleeds occurred on ticagrelor and 4 on aspirin. The composite of ICrH or fatal bleeding included 15 patients on ticagrelor and 18 on aspirin. Independently of bleeding classification, PLATO, TIMI, or GUSTO, the relative difference between treatments for major/severe bleeds was similar. Nonmajor bleeds were more common on ticagrelor. Conclusions: Antiplatelet therapy with ticagrelor in patients with acute ischemic stroke or transient ischemic attack showed a bleeding profile similar to that of aspirin for major bleeds. There were few ICrHs. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01994720.
- Published
- 2017
30. Exciting Vorticity Through Higher Order Bessel Beams With a Radial-Line Slot-Array Antenna
- Author
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Alessandro Galli, Massimiliano Casaletti, Davide Comite, Matteo Albani, Mauro Ettorre, Guido Valerio, Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni [Roma] (DIET), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Laboratoire d'Electronique et Electromagnétisme (L2E), Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Information Engineering [Sienne] (DII), Università degli Studi di Siena = University of Siena (UNISI), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' [Rome], Università degli Studi di Siena (UNISI), Institut d'Electronique et de Télécommunications de Rennes (IETR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), and Nantes Université (NU)-Université de Rennes 1 (UR1)
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radial line slot array (RLSA) ,near field ,Slot antenna ,Near and far field ,02 engineering and technology ,Radial line ,electric fields ,01 natural sciences ,symbols.namesake ,Optics ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Bessel beam, near field, orbital angular momentum (OAM), radial line slot array (RLSA), vortex beam ,Electrical and Electronic Engineering ,010306 general physics ,Physics ,Bessel beam ,business.industry ,020206 networking & telecommunications ,antennas ,Bessel functions ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,symbols ,Physics::Accelerator Physics ,orbital angular momentum (OAM) ,Antenna (radio) ,business ,Beam (structure) ,Bessel function ,vortex beam ,Beam divergence - Abstract
International audience; In this communication, it is shown that a nondiffracting vortex beam (i.e., a higher order Bessel beam with azimuthal phase variation) can be generated in the near field by synthesizing an inward cylindrical traveling-wave distribution over a finite aperture antenna. A radial line slot array (RLSA) is then designed to prove the concept. The collimated vortex beam is excited in the proximity of the RLSA, within a region properly defined by the nondiffracting range of the generated beam. The radial dependence of the longitudinal electric field of the vortex-beam magnitude follows a first-order Bessel function, and its phase presents a linear azimuthal variation. Full-wave results validate the generation of the nondiffractive higher order Bessel beam within the radiative near field of the launcher.
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- 2017
- Full Text
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31. Case study for investigating groundwater and the future of mountain spring discharges in Southern Italy
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Francesco Fiorillo, Gerardo Ventafridda, Gianni Bellocchi, Nazzareno Diodato, Met European Research Observatory (MetEROBS), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Università degli Studi di Siena (UNISI), Acquedotto Pugliese, and Università degli Studi di Siena = University of Siena (UNISI)
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010504 meteorology & atmospheric sciences ,[SDV]Life Sciences [q-bio] ,0208 environmental biotechnology ,Geography, Planning and Development ,Climate change ,Aquifer ,02 engineering and technology ,drought ,01 natural sciences ,Standard deviation ,groundwater ,Hindcast ,Groundwater discharge ,0105 earth and related environmental sciences ,Nature and Landscape Conservation ,Earth-Surface Processes ,sécheresse ,Hydrology ,Global and Planetary Change ,geography ,prévision d'ensembles ,geography.geographical_feature_category ,Hydrogeology ,Exponential smoothing ,Geology ,prévision ,6. Clean water ,020801 environmental engineering ,eau souterraine ,13. Climate action ,Climatology ,Environmental science ,prognosis ,Groundwater - Abstract
Groundwater extraction is used to alleviate drought in many habitats. However, widespread drought decreases spring discharge and there is a need to integrate climate change research into resource management and action. Accurate estimates of groundwater discharge may be valuable in improving decision support systems of hydrogeological resource exploitation. The present study performs a forecast for groundwater discharge in Aquifer’s Cervialto Mountains (southern Italy). A time series starting in 1883 was the basis for long-term predictions. An Ensemble Discharge Prediction (EDisP) was applied, and the progress of the discharge ensemble forecast was inferred with the aid of an Exponential Smoothing (ES) model initialized at different annual times. EDisP-ES hindcast model experiments were tested, and discharge plume-patterns forecast was assessed with horizon placed in the year 2044. A 46-year cycle pattern was identified by comparing simulations and observations, which is essential for the forecasting purpose. ED is P-ES performed an ensemble mean path for the coming decades that indicates a discharge regime within ± 1 standard deviation around the mean value of 4.1 m3 s−1. These fluctuations are comparable with those observed in the period 1961–1980 and further back, with change-points detectable around the years 2025 and 2035. Temporary drought conditions are expected after the year 2030.
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- 2017
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32. Circumpolar analysis of the Adélie Penguin reveals the importance of environmental variability in phenological mismatch
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William R. Fraser, Wayne Z. Trivelpiece, Karine Delord, Stéphanie Jenouvrier, Rubao Ji, Katie M. Dugger, Silvia Olmastroni, Grant Ballard, Jefferson T. Hinke, David G. Ainley, Louise Emmerson, Philip O'b. Lyver, Susan G. Trivelpiece, Heather J. Lynch, Colin Southwell, Christophe Barbraud, Yun Li, Casey Youngflesh, Department of Ecology and Evolution - USA (Stony Brook University ), Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Woods Hole Oceanographic Institution (WHOI), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Institut National de la Recherche Agronomique (INRA)-Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), College of Marine Science [St Petersburg, FL], University of South Florida (USF), Biology Department - Woods Hole Oceanographic Institution, H.T. Harvey & Associates, PRBO Conservation Science, Department of Fisheries and Wildlife, Oregon State University (OSU), Australian Antarctic Division (AAD), Australian Government, Department of the Environment and Energy, Polar Oceans Research Group [USA], Antarctic Ecosystem Research Division, Southwest Fisheries Science Center (SWFSC), NOAA National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA)-National Oceanic and Atmospheric Administration (NOAA)-NOAA National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA)-National Oceanic and Atmospheric Administration (NOAA), Landcare Research [Lincoln], Dipartimento di Scienze Ambientali 'G. Sarfatti', Università degli Studi di Siena (UNISI), State University of New York (SUNY), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of South Florida [Tampa] (USF), Manaaki Whenua – Landcare Research [Lincoln], and Università degli Studi di Siena = University of Siena (UNISI)
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0106 biological sciences ,010504 meteorology & atmospheric sciences ,quantile regression ,Climate change ,Antarctic Regions ,Anna Karenina principle ,01 natural sciences ,phenology ,Latitude ,medicine ,Animals ,14. Life underwater ,Anna Karenina Principle ,Ecology, Evolution, Behavior and Systematics ,Bayesian hierarchical model ,0105 earth and related environmental sciences ,Trophic level ,Antarctica ,asynchrony ,climate change ,Pygoscelis adeliae ,biology ,Reproductive success ,Ecology ,Phenology ,010604 marine biology & hydrobiology ,Reproduction ,Adelie penguin ,15. Life on land ,Seasonality ,biology.organism_classification ,medicine.disease ,Spheniscidae ,Geography ,Phenotype ,13. Climate action ,[SDE]Environmental Sciences ,Seasons - Abstract
Evidence of climate change-driven shifts in plant and animal phenology have raised concerns that certain trophic interactions may be increasingly mismatched in time, resulting in declines in reproductive success. Given the constraints imposed by extreme seasonality at high latitudes and the rapid shifts in phenology seen in the Arctic, we would also expect Antarctic species to be highly vulnerable to climate change-driven phenological mismatches with their environment. However, few studies have assessed the impacts of phenological change in Antarctica. Using the largest database of phytoplankton phenology, sea-ice phenology, and Adelie penguin breeding phenology and breeding success assembled to date, we find that while a temporal match between penguin breeding phenology and optimal environmental conditions sets an upper limit on breeding success, only a weak relationship to the mean exists. Despite previous work suggesting that divergent trends in Adelie penguin breeding phenology are apparent across the Antarctic continent, we find no such trends. Furthermore, we find no trend in the magnitude of phenological mismatch, suggesting that mismatch is driven by interannual variability in environmental conditions rather than climate change-driven trends, as observed in other systems. We propose several criteria necessary for a species to experience a strong climate change-driven phenological mismatch, of which several may be violated by this system. This article is protected by copyright. All rights reserved.
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- 2017
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33. Optimized time-domain control of passive haptic teleoperation systems for multi-DoF interaction
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Bianchini, Gianni, Barcelli, Davide, Prattichizzo, Domenico, Pacchierotti, Claudio, Università degli Studi di Siena = University of Siena (UNISI), Istituto Italiano di Tecnologia (IIT), Sensor-based and interactive robotics (RAINBOW), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-RÉALITÉ VIRTUELLE, HUMAINS VIRTUELS, INTERACTIONS ET ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
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Optimization ,Passivity ,[INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO] ,Time-domain control ,Haptic-enabled teleoperation - Abstract
International audience; This paper presents a time-domain passivity controller for multi-DoF haptic-enabled teleoperation systems aimed at improving performance in terms of transparency for a given task. By solving an online convex optimization problem, the proposed approach enhances transparency of interaction along specific directions of the environment space which are significant for the task at hand, while guaranteeing system stability. An experimental evaluation of the effectiveness of the proposed design is presented, enrolling twenty participants. We compared the performance of the proposed approach vs. those of a standard energy-bounding time-domain algorithm during the exploration of a virtual sphere. Results show that, as the communication delay between the local and remote agents grows, the proposed technique better preserves transparency along the directions that are more important for the task at hand.
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- 2023
34. Encounter-Type Haptic Device Enabling Edges, Vertexes and Plane Palm Interaction: the Haptic Origami Device
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Gomez Hernandez, Pedro, Kuang, Lisheng, Malvezzi, Monica, Prattichizzo, Domenico, Robuffo Giordano, Paolo, Pacchierotti, Claudio, Chinello, Francesco, Aarhus University [Aarhus], Sensor-based and interactive robotics (RAINBOW), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-RÉALITÉ VIRTUELLE, HUMAINS VIRTUELS, INTERACTIONS ET ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Università degli Studi di Siena = University of Siena (UNISI), and Italian Institute of Technology (IIT)
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[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] - Abstract
International audience
- Published
- 2023
35. LF RFID chequered loop antenna for pebbles on the beach detection
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Y. Le Bihan, Antoine Diet, Marc Biancheri-Astier, Gaelle Lissorgues, M. Benamara, Christophe Conessa, F. Alves, Alessandro Pozzebon, Marjorie Grzeskowiak, Laboratoire Génie électrique et électronique de Paris (GeePs), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Electronique, Systèmes de communication et Microsystèmes (ESYCOM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris, Università degli Studi di Siena = University of Siena (UNISI), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris, Conservatoire National des Arts et Métiers - CNAM (FRANCE), Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole de l'Innovation Technologique - ESIEE PARIS (FRANCE), Sorbonne Université (FRANCE), CentraleSupélec (FRANCE), Université Paris-Est Marne-La-Vallée - UPEM (FRANCE), Università degli Studi di Siena - UNISI (ITALY), and Université Paris-Sud 11 (FRANCE)
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Engineering ,Computer Networks and Communications ,LF RFID ,Context (language use) ,Electromagnétisme ,02 engineering and technology ,Low frequency ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,Electrical and Electronic Engineering ,MATLAB ,Instrumentation ,computer.programming_language ,Radiation ,Orientation (computer vision) ,business.industry ,Loop antenna ,020208 electrical & electronic engineering ,Electrical engineering ,020206 networking & telecommunications ,Power (physics) ,Magnetic coupling ,Loop (topology) ,Inductance ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,business ,computer - Abstract
International audience; This paper focus on low frequency (125 kHz) RFID by magnetic coupling, more precisely using glasstag type of tags in the context of pebble detection on the beach. The challenge is to detect over a wide area very small size tags which are highly sensitive to the orientation of the magnetic field. To improve the detection ability of the reader loop antenna, the paper proposes to exploit the principle of complementary loops. Theoretical simulations with MATLAB show the potential increase by means of mutual inductance value along a displacement of the tag. A prototype of a chequered loop structure is presented and tested with a classical low power RFID reader to demonstrate the improvement without increasing the current in LF reader loops. The detection performances reach 12,8% for a 900 cm 2 surface of a prototype reader loop, whatever the orientation of the glasstag.
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- 2016
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36. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives
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Tatiana Gorojankina, Lucile Hoch, André Mann, Fabrizio Manetti, Annalisa Gabrielli, Laurent Brasseur, Elena Petricci, Martial Ruat, Hélène Faure, Maurizio Taddei, Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena = University of Siena (UNISI), Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Laboratoire d'Innovation Thérapeutique (LIT), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC), Institut des Neurosciences Paris-Saclay (NeuroPSI), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
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0301 basic medicine ,Purmorphamine ,Models, Molecular ,Hedgehog signaling pathway ,Osteogenic activity ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Drug Evaluation, Preclinical ,Structure-activity relationships ,Chemistry Techniques, Synthetic ,Stem cells ,Pharmacology ,Quinolones ,Smoothened agonists ,Regenerative medicine ,03 medical and health sciences ,Mice ,Structure-Activity Relationship ,Synthesis ,Osteogenesis ,Drug Discovery ,Animals ,Hedgehog Proteins ,Hedgehog ,Pharmacophore ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,Activator (genetics) ,Chemistry ,Heterocycle ,Drug Discovery3003 Pharmaceutical Science ,Mesenchymal stem cell ,Organic Chemistry ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,General Medicine ,3. Good health ,Cell biology ,030104 developmental biology ,Drug Design ,NIH 3T3 Cells ,Smoothened - Abstract
International audience; Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4-0.9 μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.
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- 2016
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37. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway
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Elena Petricci, Fabrizio Manetti, Soazig Le Lay, Lucile Hoch, André Mann, Hélène Faure, Audrey Fleury, Nicolas Girard, Maurizio Taddei, M. Carmen Martinez, Jérôme Larghero, Ramaroson Andriantsitohaina, Caroline Jacques, Martial Ruat, Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena = University of Siena (UNISI), Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Laboratoire d'Innovation Thérapeutique (LIT), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC), CIC - Biotherapie - Saint Louis ((CIC-BT 301)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut des Neurosciences de Paris-Saclay (Neuro-PSI), Università degli Studi di Siena (UNISI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Stress oxydant et pathologies métaboliques, Université d'Angers ( UA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut des Neurosciences de Paris-Saclay ( Neuro-PSI ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Università degli Studi di Siena ( UNISI ), Laboratoire d'Innovation Thérapeutique ( LIT ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), CIC - Biotherapie- Saint Louis, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance Publique - Hôpitaux de Paris, and Assistance publique - Hôpitaux de Paris (AP-HP)
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0301 basic medicine ,medicine.medical_specialty ,PROTEINS ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Cellular differentiation ,Article ,[ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Mice ,03 medical and health sciences ,3T3-L1 Cells ,Internal medicine ,Adipocytes ,medicine ,Animals ,Humans ,Hedgehog Proteins ,SMOOTHENED RECEPTOR ,Sonic hedgehog ,SONIC HEDGEHOG ,ENDOTHELIAL-CELLS ,EXTRACELLULAR VESICLES ,SIGNALING PATHWAY ,PRIMARY CILIUM ,LIPID RAFTS ,STEM-CELLS ,ADIPOGENESIS ,Hedgehog ,Cells, Cultured ,Multidisciplinary ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,biology ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Cell Differentiation ,Mesenchymal Stem Cells ,Cell biology ,Smoothened Receptor ,030104 developmental biology ,Endocrinology ,Adipogenesis ,[ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,biology.protein ,Signal transduction ,Smoothened ,Transcription Factors ,Morphogen - Abstract
Hedgehog (Hh) is a critical regulator of adipogenesis. Extracellular vesicles are natural Hh carriers, as illustrated by activated/apoptotic lymphocytes specifically shedding microparticles (MP) bearing the morphogen (MPHh+). We show that MPHh+ inhibit adipocyte differentiation and orientate mesenchymal stem cells towards a pro-osteogenic program. Despite a Smoothened (Smo)-dependency, MPHh+ anti-adipogenic effects do not activate a canonical Hh signalling pathway in contrast to those elicited either by the Smo agonist SAG or recombinant Sonic Hedgehog. The Smo agonist GSA-10 recapitulates many of the hallmarks of MPHh+ anti-adipogenic effects. The adipogenesis blockade induced by MPHh+ and GSA-10 was abolished by the Smo antagonist LDE225. We further elucidate a Smo/Lkb1/Ampk axis as the non-canonical Hh pathway used by MPHh+ and GSA-10 to inhibit adipocyte differentiation. Our results highlight for the first time the ability of Hh-enriched MP to signal via a non-canonical pathway opening new perspectives to modulate fat development.
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- 2016
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38. Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi
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Andrea Medeiros, Francesca Moraca, Marcelo A. Comini, Maurizio Botta, Cecilia Ortíz, Niall M. Hamilton, Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Università degli Studi di Siena = University of Siena (UNISI), Universidad de la República [Montevideo] (UCUR), Drug Discovery Unit, Cancer Research, UK Manchester Institute, Wilmslow Road, Manchester, CO acknowledges support from ANII (Agencia Nacional de Investigación e Innovación, Uruguay, and doctoral fellowship POS_NAC_2012_1_8803) and CSIC (Comisión Sectorial de Investigaciones Científicas, Universidad de la República Uruguay). CSIC and the Coimbra Group is acknowledged, the last for supporting a research traineeship at the Università degli Studi di Siena, is acknowledged by AM. MAC acknowledges the financial support of FOCEM (MERCOSUR Structural Convergence Fund) COF 03/11 and grant INNOVA Uruguay (agreement No. DCI-ALA/2007/19.040 between Uruguay and the European Commision). We acknowledge Cameron F. Abrams (Drexel University, Philadelphia, PA, USA) for the computational resourcesand help
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0301 basic medicine ,Chagas disease ,[SDV]Life Sciences [q-bio] ,Pharmaceutical Science ,Dehydrogenase ,Epiandrosterone ,Analytical Chemistry ,Drug Discovery ,MESH: Trypanocidal Agents ,chemistry.chemical_classification ,Leishmania ,biology ,structure activity relationship ,Trypanocidal Agents ,Molecular Docking Simulation ,epiandrosterone ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Biochemistry ,Chemistry (miscellaneous) ,Molecular Medicine ,Steroids ,Ribosemonophosphates ,MESH: Trypanosoma cruzi ,Stereochemistry ,Trypanosoma cruzi ,MESH: Glucosephosphate Dehydrogenase ,pentose phosphate pathway ,Glucosephosphate Dehydrogenase ,Androsterone ,Article ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,MESH: Androsterone ,MESH: Molecular Docking Simulation ,Structure–activity relationship ,Humans ,MESH: Chagas Disease ,Physical and Theoretical Chemistry ,Binding site ,inhibition by steroids ,Binding Sites ,MESH: Humans ,Organic Chemistry ,Active site ,biology.organism_classification ,MESH: Steroids ,030104 developmental biology ,Enzyme ,chemistry ,MESH: Binding Sites ,biology.protein ,Uncompetitive inhibitor ,MESH: Ribosemonophosphates - Abstract
International audience; Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate). Based on its indispensability for pathogenic parasites from the genus Trypanosoma, G6PDH is considered a drug target candidate. Several steroid-like scaffolds were previously reported to target the activity of G6PDH. Epiandrosterone (EA) is an uncompetitive inhibitor of trypanosomal G6PDH for which its binding site to the enzyme remains unknown. Molecular simulation studies with the structure of Trypanosoma cruzi G6PDH revealed that EA binds in a pocket close to the G6P binding-site and protrudes into the active site blocking the interaction between substrates and hence catalysis. Site directed mutagenesis revealed the important steroid-stabilizing effect of residues (L80, K83 and K84) located on helix α-1 of T. cruzi G6PDH. The higher affinity and potency of 16α-Br EA by T. cruzi G6PDH is explained by the formation of a halogen bond with the hydrogen from the terminal amide of the NADP+-nicotinamide. At variance with the human enzyme, the inclusion of a 21-hydroxypregnane-20-one moiety to a 3β-substituted steroid is detrimental for T. cruzi G6PDH inhibition. The species-specificity of certain steroid derivatives towards the parasite G6PDH and the corresponding biochemically validated binding models disclosed in this work may prove valuable for the development of selective inhibitors against the pathogen's enzyme.
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- 2016
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39. Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells
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Maurizio Taddei, Alessandra Chiarenza, Elena Petricci, Fabrizio Manetti, Antonella Naldini, Martial Ruat, Fabio Carraro, Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena = University of Siena (UNISI), Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), and Istituto Toscano Tumori
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[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Protein Expression ,Fusion Proteins, bcr-abl ,Apoptosis ,MESH: Receptors, G-Protein-Coupled ,Pharmacology ,Biochemistry ,Receptors, G-Protein-Coupled ,0302 clinical medicine ,Cell Signaling ,MESH: Protein Kinase Inhibitors ,Small interfering RNAs ,lcsh:Science ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,CHRONIC MYELOGENOUS LEUKEMIA ,Smoothened Receptor ,Hedgehog signaling pathway ,MESH: Drug Resistance, Neoplasm ,3. Good health ,Nucleic acids ,RNA isolation ,030220 oncology & carcinogenesis ,Imatinib Mesylate ,Neoplastic Stem Cells ,MESH: Blast Crisis ,Biomolecular isolation ,MESH: Protein-Tyrosine Kinases ,03 medical and health sciences ,GLI1 ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,Genetics ,Humans ,MESH: Autophagy ,Non-coding RNA ,neoplasms ,Molecular Biology Assays and Analysis Techniques ,MESH: K562 Cells ,MESH: Humans ,MESH: Fusion Proteins, bcr-abl ,lcsh:R ,Biology and Life Sciences ,SELECTIVE INHIBITOR ,IN-VITRO ,medicine.disease ,MESH: Neoplastic Stem Cells ,HEDGEHOG PATHWAY ACTIVATION ,BCR-ABL ,SONIC HEDGEHOG ,STEM-CELLS ,TYROSINE KINASE ,STEM/PROGENITOR CELLS ,SIGNALING PATHWAY ,Molecular biology techniques ,030104 developmental biology ,MESH: Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,lcsh:Q ,Gene expression ,Smoothened ,MESH: MicroRNAs ,0301 basic medicine ,MESH: Signal Transduction ,Molecular biology ,lcsh:Medicine ,hemic and lymphatic diseases ,Multidisciplinary ,Cell Death ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Protein-Tyrosine Kinases ,Cell Processes ,Stem cell ,Signal Transduction ,Research Article ,medicine.drug ,MESH: Cell Line, Tumor ,MESH: Imatinib Mesylate ,Nucleic acid synthesis ,Biology ,Cell Line, Tumor ,MESH: Cell Proliferation ,Autophagy ,Gene Expression and Vector Techniques ,medicine ,Hedgehog Proteins ,Chemical synthesis ,RNA synthesis ,Protein Kinase Inhibitors ,Cell Proliferation ,MESH: Apoptosis ,Imatinib ,Cell Biology ,MESH: Hedgehog Proteins ,Gene regulation ,Research and analysis methods ,MicroRNAs ,Biosynthetic techniques ,Drug Resistance, Neoplasm ,Hedgehog Signaling ,biology.protein ,RNA ,Blast Crisis ,K562 Cells ,Chronic myelogenous leukemia ,K562 cells - Abstract
International audience; The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient's life expectancy and survival. Unfortunately, there are some issues TKIs are not able to address; first of all TKIs are not so effective in increasing survival of patients in blast crisis, second they are not able to eradicate leukemic stem cells (LSC) which represent the major cause of disease relapse, and third patients often develop resistance to TKIs due to mutations in the drug binding site. For all these reasons it's of primary interest to find alternative strategies to treat CML. Literature shows that Hedgehog signaling pathway is involved in LSC maintenance, and pharmacological inhibition of Smoothened (SMO), one of the key molecules of the pathway, has been demonstrated to reduce Bcr-Abl positive bone marrow cells and LSC. Consequently, targeting SMO could be a promising way to develop a new treatment strategy for CML overcoming the limitations of current therapies. In our work we have tested some compounds able to inhibit SMO, and among them MRT92 appears to be a very potent SMO antagonist. We found that almost all our compounds were able to reduce Gli1 protein levels in K-562 and in KU-812 CML cell lines. Furthermore, they were also able to increase Gli1 and SMO RNA levels, and to reduce cell proliferation and induce apoptosis/autophagy in both the tested cell lines. Finally, we demonstrated that our compounds were able to modulate the expression of some miRNAs related to Hedgehog pathway such as miR-324-5p and miR-326. Being Hedgehog pathway deeply implicated in the mechanisms of CML we may conclude that it could be a good therapeutic target for CML and our compounds seem to be promising antagonists of such pathway.
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- 2016
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40. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain
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Lorenzo Di Cesare Mannelli, Livio Luongo, Vincenzo Di Marzo, Margherita Brindisi, Kwang-Mook Jung, Giuseppe Campiani, Anna Pittaluga, Beatrice Gorelli, Fabiana Piscitelli, Carla Ghelardini, Andrea Armirotti, Daniele Tedesco, Christophe Landry, Emanuele Gabellieri, Stefania Lamponi, Stefania Butini, Sandra Gemma, Carlo Bertucci, Alessia Ligresti, Samuele Maramai, Alessandro Grillo, Simone Brogi, Simona Saponara, Marie Pierre Dehouck, Tommaso Bonfiglio, Daniele Piomelli, Sabatino Maione, Brindisi, Margherita, Maramai, Samuele, Gemma, Sandra, Brogi, Simone, Grillo, Alessandro, Di Cesare Mannelli, Lorenzo, Gabellieri, Emanuele, Lamponi, Stefania, Saponara, Simona, Gorelli, Beatrice, Tedesco, Daniele, Bonfiglio, Tommaso, Landry, Christophe, Jung, Kwang Mook, Armirotti, Andrea, Luongo, Livio, Ligresti, Alessia, Piscitelli, Fabiana, Bertucci, Carlo, Dehouck, Marie Pierre, Campiani, Giuseppe, Maione, Sabatino, Ghelardini, Carla, Pittaluga, Anna, Piomelli, Daniele, Di Marzo, Vincenzo, Butini, Stefania, European Research Centre for Drug Discovery and Development, Banchi di Sotto 55 and Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena (UNISI), UNIVERSITY OF FIRENZE (UNIVERSITY OF FIRENZE), Università degli Studi di Firenze [Firenze], University of Siena (University of Siena), University of Bologna, University of Genova [Genova, Italy], Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UA), University of California, Instituto Italiano di Tecnologia (IIT), Ministero dell'Istruzione-Ministero dell'Economia e Finanze, Second University of Napoli, Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ENDOCANNABINOID RESEARCH GROUP), Consiglio Nazionale delle Ricerche [Roma] (CNR), Institute of Biomolecular Biology, Consiglio Nazionale delle Ricerche (CNR), Department of Pharmacology, Università degli Studi di Siena = University of Siena (UNISI), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Jung, Kwang-Mook, Dehouck, Marie-Pierre, Brindisi, M, Maramai, S, Gemma, S, Brogi, S, Grillo, A, Di Cesare Mannelli, L, Gabellieri, E, Lamponi, S, Saponara, S, Gorelli, B, Tedesco, D, Bonfiglio, T, Landry, C, Jung, Km, Armirotti, A, Ligresti, A, Piscitelli, F, Bertucci, C, Dehouck, Mp, Campiani, G, Ghelardini, C, Pittaluga, A, Piomelli, D, Di Marzo, V, and Butini, S.
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0301 basic medicine ,Models, Molecular ,Proteomics ,Cannabinoid receptor ,Organoplatinum Compounds ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Pharmacology ,Receptor, Cannabinoid, CB2 ,Mice ,Receptor, Cannabinoid, CB1 ,HEK293 Cell ,Models ,Drug Discovery ,Multiple Sclerosi ,Cannabinoid receptor type 2 ,Encephalomyelitis ,Arachidonic Acid ,Chemistry ,Medicine (all) ,beta-lactams ,Chronic pain ,Brain ,Animals ,Arachidonic Acids ,Blood-Brain Barrier ,Cell Membrane ,Drug Design ,Encephalomyelitis, Autoimmune, Experimental ,Endocannabinoids ,Glycerides ,HEK293 Cells ,Humans ,Monoacylglycerol Lipases ,Multiple Sclerosis ,Mutagenicity Tests ,Neuralgia ,Pain ,Permeability ,Structure-Activity Relationship ,Molecular Medicine ,Drug Discovery3003 Pharmaceutical Science ,CB1 ,CB2 ,3. Good health ,Oxaliplatin ,lipids (amino acids, peptides, and proteins) ,MGL inhibitors ,medicine.symptom ,Human ,Receptor ,Monoacylglycerol Lipase ,Membrane permeability ,Neurophysiology ,Peptides and proteins ,Multiple sclerosis ,03 medical and health sciences ,Experimental ,medicine ,Inverse agonist ,Cannabinoid ,Endocannabinoid ,neuropathic pain ,Inhibitors ,Animal ,Organoplatinum Compound ,β-lactams ,Molecular ,Proteomic ,Multiple sclerosis, MGL inhibitors, neuropathic pain, beta-lactams ,medicine.disease ,Encephalomyeliti ,Monoacylglycerol lipase ,030104 developmental biology ,Mechanism of action ,Mutagenicity Test ,Central nervous system ,Glyceride ,MAGL ,Model ,Autoimmune - Abstract
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal ofMedicinal Chemistry, 59, 2612–2632 (DOI: 10.1021/acs.jmedchem.5b01812), © 2016 American ChemicalSociety, after peer review and technical editing by the publisher. To access the final edited and published work,see http://pubsdc3.acs.org/articlesonrequest/AOR-teeM6WpzZVZ52Aqz9AMW This Manuscript version is made available under the CC-BY-NC-ND 4.0license.https://creativecommons.org/licenses/by-nc-nd/4.0/ ABSTRACT We report the discovery of compound4a, a potent β-lactam-based monoacylglycerol lipase (MGL) inhibitor characterized by an irreversible and stereoselective mechanism of action, high membrane permeability, high brain penetration evaluated using a human in vitro blood–brain barrier model, high selectivity in binding and affinity-based proteomic profiling assays, and low in vitro toxicity. Mode-of-action studies demonstrate that4a, by blocking MGL, increases 2-arachidonoylglycerol and behaves as a cannabinoid (CB1/CB2) receptor indirect agonist. Administration of4ain mice suffering from experimental autoimmune encephalitis ameliorates the severity of the clinical symptoms in a CB1/CB2-dependent manner. Moreover,4aproduced analgesic effects in a rodent model of acute inflammatory pain, which was antagonized by CB1 and CB2 receptor antagonists/inverse agonists.4aalso relieves the neuropathic hypersensitivity induced by oxaliplatin. Given these evidence,4a, as MGL selective inhibitor, could represent a valuable lead for the future development of therapeutic options for multiple sclerosis and chronic pain.
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- 2016
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41. Mode-Matching Analysis of Lossy SIW Devices
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Ronan Sauleau, G. Valerio, Matteo Albani, Massimiliano Casaletti, Laboratoire d'Electronique et Electromagnétisme (L2E), Université Pierre et Marie Curie - Paris 6 (UPMC), Institut d'Electronique et de Télécommunications de Rennes (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Department of Information Engineering [Sienne] (DII), Università degli Studi di Siena (UNISI), ANR 12-EMMA-0041-01, Agence Nationale de la Recherche, DGCIS (FUI 10, DENOTEIC), Institut d'Électronique et des Technologies du numéRique (IETR), Università degli Studi di Siena = University of Siena (UNISI), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), and Nantes Université (NU)-Université de Rennes 1 (UR1)
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Waveguide (electromagnetism) ,Matching (graph theory) ,Computer science ,02 engineering and technology ,Lossy compression ,Topology ,01 natural sciences ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Scattering parameters ,Green's functions ,Boundary value problem ,Conductor losses ,method of moments (MoM) ,substrate-integrated waveguide (SIW) ,Radiation ,Condensed Matter Physics ,Electrical and Electronic Engineering ,Simulation ,010302 applied physics ,Commercial software ,020206 networking & telecommunications ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,Phase shift module ,Microwave - Abstract
International audience; In this paper, we present a method for the analysis of lossy substrate-integrated waveguide structures. The analysis is achieved through the cylindrical-wave mode expansion of the field and a mode matching technique to enforce boundary conditions on the post surfaces. We introduce an approximated formulation of the previous exact procedure, valid in the microwave regime, and numerically examine a number of microwave devices using both approximated and exact analyses. These devices include filters, couplers, phase shifter, and so on. Results are presented for the scattering parameters and compared with those obtained with the commercial software in terms of accuracy and computational time.
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- 2016
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42. A 4-DoF Wearable Hand Device for Haptic Rendering of Surfaces and Edges
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Kuang, Lisheng, Malvezzi, Monica, Ferro, Marco, Prattichizzo, Domenico, Robuffo Giordano, Paolo, Chinello, Francesco, Pacchierotti, Claudio, Sensor-based and interactive robotics (RAINBOW), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-RÉALITÉ VIRTUELLE, HUMAINS VIRTUELS, INTERACTIONS ET ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Università degli Studi di Siena = University of Siena (UNISI), Istituto Italiano di Tecnologia (IIT), and Aarhus University [Aarhus]
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wearables ,haptics ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] - Abstract
We present a 4-degrees-of-freedom (4-DoF) wearable haptic device for the palm, able to provide the sensation of interacting with slanted surfaces and edges. It is composed of a static upper body, secured to the back of the hand, and a mobile end-effector, placed in contact with the palm. They are connected by two articulated arms, actuated by four servo motors housed on the upper body and along the arms. The end-effector is a foldable flat surface that can make/break contact with the palm to provide pressure feedback, move sideways to provide skin stretch and tangential motion feedback, and fold to elicit the sensation of interacting with different curvatures. The paper presents the design of the wearable haptic device, together with its mobility, statics, and manipulability, as well as direct, inverse, and differential kinematics. We also present a position control scheme for the device, which is then quantitatively evaluated.
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- 2023
43. A Wearable Haptic Device for the Hand with Interchangeable End-Effectors
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Kuang, Lisheng, Ferro, Marco, Malvezzi, Monica, Prattichizzo, Domenico, Robuffo Giordano, Paolo, Chinello, Francesco, Pacchierotti, Claudio, Sensor-based and interactive robotics (RAINBOW), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-RÉALITÉ VIRTUELLE, HUMAINS VIRTUELS, INTERACTIONS ET ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Dipartimento di Ingegneria dell'informazione e scienze matematiche [Siena] (DIISM), Università degli Studi di Siena = University of Siena (UNISI), Istituto Italiano di Tecnologia (IIT), and Aarhus University [Aarhus]
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Virtual Reality ,Wearable haptics ,Haptics ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Human-computer interaction - Abstract
International audience; This paper presents a 4-degrees-of-freedom (4-DoF) hand wearable haptic device for Virtual Reality (VR). It is designed to support different end-effectors, that can be easily exchanged so as to provide a wide range of haptic sensations. The device is composed of a static upper body, secured to the back of the hand, and the (changeable) end-effector, placed in contact with the palm. The two parts of the device are connected by two articulated arms, actuated by four servo motors housed on the upper body and along the arms. The paper summarizes the design and kinematics of the wearable haptic device and presents a position control scheme able to actuate a broad range of endeffectors. As a proof of concept, we present and evaluate three representative end-effectors during interactions in VR, rendering the sensation of interacting (E1) with rigid slanted surfaces and sharp edges having different orientations, (E2) with curved surfaces having different curvatures, and (E3) with soft surfaces having different stiffness characteristics. A few additional endeffector designs are discussed. A human-subjects evaluation in immersive VR shows the broad applicability of the device, able to render rich interactions with a diverse set of virtual objects.
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- 2023
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44. Un autre regard sur l'objet
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Batranu, Raluca, Borghino, Elisa, Patroix, Isabelle, Madou, Jean-Pol, Baptiste, Nicolas, Diaz, Sylvain, Landrea, Cyrielle, Clo, Magdeleine, Rubessi, Chiara, Ramirez Cifola, Cécile, Pele, Ioana, Baldassarre, Maria Rosaria, Spinelli, Manuela, Drumm, Thierry, Călin, Anca, Grandone, Salvatore, Montagner, Eleonora, Kohlhauer, Michael, Langages, Littératures, Sociétés, Études Transfrontalières et Internationales ( LLSETI ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Université Panthéon-Sorbonne ( UP1 ), Aix Marseille Université ( AMU ), Université Stendhal - Grenoble 3, LITT&ARTS. Arts et pratiques du texte, de l’image, de l’écran et de la scène ( LITT&ARTS ), Université Stendhal - Grenoble 3-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), CINESTHEA, Équipe de recherches sur l'histoire, les théories et la didactique de la littérature et des arts du spectacle des 19e, 20e et 21e siècles ( Traverses 19-21 ), Université Stendhal - Grenoble 3-Université Stendhal - Grenoble 3, Institut des Langues et des Cultures d'Europe et d'Amérique ( ILCEA ), Université d'Oradea, Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ), Università degli Studi di Siena ( UNISI ), Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ), Université d'Avignon et des Pays de Vaucluse ( UAPV ), Université Libre de Bruxelles [Bruxelles] ( ULB ), Dunarea de Jos Galati, Université de Bourgogne ( UB ), Fondazione Collegio San Carlo, Modena, Raluca Batranu, Elisa Borghino, Isabelle Patroix, Langages, Littératures, Sociétés, Études Transfrontalières et Internationales (LLSETI), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université Paris 1 Panthéon-Sorbonne (UP1), Aix Marseille Université (AMU), LITT&ARTS. Arts et pratiques du texte, de l’image, de l’écran et de la scène (LITT&ARTS ), Université Stendhal - Grenoble 3-Centre National de la Recherche Scientifique (CNRS), Équipe de recherches sur l'histoire, les théories et la didactique de la littérature et des arts du spectacle des 19e, 20e et 21e siècles (Traverses 19-21), Institut des Langues et Cultures d'Europe, Amérique, Afrique, Asie et Australie (ILCEA4), University of Oradea, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Università degli Studi di Siena = University of Siena (UNISI), Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES), Avignon Université (AU), Université libre de Bruxelles (ULB), Université de Bourgogne (UB), Kulesiak, Anna, LITT&ARTS. Arts et pratiques du texte, de l’image, de l’écran et de la scène (LITT&ARTS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
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[SHS.SOCIO]Humanities and Social Sciences/Sociology ,[SHS.LITT]Humanities and Social Sciences/Literature ,[ SHS.HIST ] Humanities and Social Sciences/History ,[SHS.SOCIO] Humanities and Social Sciences/Sociology ,Représentation ,[SHS.PHIL]Humanities and Social Sciences/Philosophy ,Objet ,[ SHS.SOCIO ] Humanities and Social Sciences/Sociology ,[ SHS.LITT ] Humanities and Social Sciences/Literature ,[SHS.LITT] Humanities and Social Sciences/Literature ,[SHS.PHIL] Humanities and Social Sciences/Philosophy ,[ SHS.PHIL ] Humanities and Social Sciences/Philosophy ,[SHS.HIST] Humanities and Social Sciences/History ,[SHS.HIST]Humanities and Social Sciences/History - Abstract
International audience; À la lumière croisée de la littérature, de l'histoire, de la philosophie et de la sociologie, les communicants des journées d'études doctorales du laboratoire LLS de l’université de Savoie de 2012 se sont emparés de l’objet, de son pouvoir polysémique, de ses multiples facettes, pour y apporter un regard nouveau.Ils abordent tour à tour, les objets historiques porteurs de l’Histoire et des histoires, les objets révélateurs d’identités, ou encore la perception même que nous avons de l’objet.Traversant les siècles, les romans grecs anciens, la Rome antique, le Moyen Âge ou encore le XIXe et le XXe ; traversant les auteurs d’ici (Diderot, Brecht, A. Ernaux, Maurice Blanchot, Beckett, François Bon) et d’ailleurs (Brecht, Werner Herzog, Roberto Saviano, Del Giudice, Mari Silvina Ocampo, Bergson, Maurice Merleau-Ponty, Berkeley) les communications furent riches et stimulantes.Le présent ouvrage permet d’illustrer les questionnements pertinents qui ont éclos lors de ces journées d’études et de poursuivre les réflexions commencées en présentant également les articles de Jean-Pol Madou, Beckett et Berkeley : esse est percipi et de Michael Kohlhauer, Choses vues du train : François Bon, "Paysages fer".SOMMAIREIntroductionRaluca BATRANU, Elisa BORGHINO, Isabelle PATROIX 9Beckett et Berkeley: esse est percipiJean-Pol MADOU 17Partie IObjets conteurs d'histoire(s) 25Nouveaux regards sur l'objet: la question de l’authenticité, relations entre chercheur et objet d’histoireNicolas BAPTISTE 27Les inscriptions, des objets porteurs de la mémoire nobiliaire dans la Rome antiqueCyrielle LANDREA 45Accessoire, l’accessoire? Petite histoire de l’objet au théâtreSylvain DIAZ 55Le vêtement, miroir du corps Érotisation de l’objet dans les romans grecs anciensMagdeleine CLO 65"Fitzcarraldo" de Werner Herzog. Le bâteau comme rêve et folieChiara RUBESSI 75Partie IIObjets révélateurs d’identité(s) 85Un regard littéraire sur l’objet-miroir et son pouvoir sémantique dans « Cornelia devant le miroir» de Silvina OcampoCécile RAMIREZ CIFOLA 87Entrer dans le miroirIoana PELE 101La marchandise, la parole littéraire: Objets-protagonistes de Gomorra de Roberto SavianoMaria Rosaria BALDASSARRE 113Entre souvenir et connaissance. Les objets dans l’œuvre de Del Giudice et MariManuela SPINELLI 125Les photos pour le direRaluca BATRANU 137Partie IIIObjet réel, objet représenté 151Ce secret que l’univers connaît par cœur. Le pragmatisme, les objets et les chosesThierry DRUMM 153Un objet à double face. Le mot dans l’espace littéraire de Maurice BlanchotAnca CĂLIN 167Repenser la critique littéraire par Bergson?Salvatore GRANDONE 181Comment quelque chose qui est là devient quelque chose qui est ici. Un point de vue organique dans les rapports entre l’homme et l’objetEleonora MONTAGNER 193Choses vues du train: François Bon, "Paysages fer"Michael KOHLHAUER 203
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- 2015
45. Optimization of biomass supply-chain logistics and sustainability assessment. The case of Miscanthus at Bourgogne Pellets, France
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PERRIN, Aurélie, Wohlfahrt, Julie, Flatberg, Truls, Morandi, Fabiana, De la Rúa, Cristina, Østergård, Hanne, Bjorkvoll, Thor Harald, Gabrielle, Benoit, Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris-Saclay, Agro-Systèmes Territoires Ressources Mirecourt (ASTER Mirecourt), Institut National de la Recherche Agronomique (INRA), Department of Applied Economics, Stiftelsen for INdustriell og TEknisk Forskning Digital [Trondheim] (SINTEF Digital), Department of Physical Sciences, Earth and Environment [Siena] (DSFTA), Università degli Studi di Siena = University of Siena (UNISI), Department of Energy, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Association of Applied Biologists. GBR., Stiftelsen for Industriell og Teknisk Forskning (SINTEF), Università degli Studi di Siena (UNISI), Department of Chemical and Biochemical Engineering, and Technical University of Denmark [Lyngby] (DTU)
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spatial ,biomass ,logistics ,[SDE.MCG]Environmental Sciences/Global Changes ,food and beverages ,miscanthus ,feedstock ,complex mixtures ,[SDE.ES]Environmental Sciences/Environmental and Society - Abstract
Optimization of biomass supply-chain logistics and sustainability assessment. The case of Miscanthus at Bourgogne Pellets, France. Biomass and Energy Crops V
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- 2015
46. Low-Earth Orbit User Segment in the Ku and Ka-Band: An Overview of Antennas and RF Front-End Technologies
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Giandomenico Amendola, Daniele Cavallo, Tobias Chaloun, Nicolas Defrance, George Goussetis, Marc Margalef-Rovira, Enrica Martini, Oscar Quevedo-Teruel, Vaclav Valenta, Nelson J.G. Fonseca, Mauro Ettorre, Dipartimento di Ingegneria Informatica, Modellistica, Elettronica e Sistemistica [Calabria] (DIMES), Università della Calabria [Arcavacata di Rende] (Unical), Delft University of Technology (TU Delft), Universität Ulm - Ulm University [Ulm, Allemagne], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Puissance - IEMN (PUISSANCE - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Heriot-Watt University [Edinburgh] (HWU), Università degli Studi di Siena = University of Siena (UNISI), Royal Institute of Technology [Stockholm] (KTH ), Agence Spatiale Européenne = European Space Agency (ESA), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, and Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)
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Low earth orbit satellites ,[PHYS]Physics [physics] ,Satellite antennas ,[SPI]Engineering Sciences [physics] ,Radiation ,Satellites ,Radio frequency, Satellite antennas, Satellites, Array signal processing, Low earth orbit satellites, Microwave communication, Orbits ,Radio frequency ,Array signal processing ,Orbits ,Electrical and Electronic Engineering ,Microwave communication ,Condensed Matter Physics - Abstract
International audience; Low-Earth orbit (LEO) constellations are revolutionizing the world of satellite communication (Satcom), providing new opportunities to manufacturers and operators and enabling innovative and attractive services to users.
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- 2023
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47. Logic Explained Networks
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Gabriele Ciravegna, Pietro Barbiero, Francesco Giannini, Marco Gori, Pietro Liò, Marco Maggini, Stefano Melacci, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Modèles et algorithmes pour l’intelligence artificielle (MAASAI), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Laboratoire Jean Alexandre Dieudonné (LJAD), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA), University of Cambridge [UK] (CAM), Università degli Studi di Siena = University of Siena (UNISI), Interdisciplinary Institute for Artificial Intelligence (3iA Côte d’Azur), and ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019)
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Computer Science - Logic in Computer Science ,Linguistics and Language ,Computer Science - Artificial Intelligence ,Computer Science - Neural and Evolutionary Computing ,Language and Linguistics ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Logic Explained Networks ,Machine Learning (cs.LG) ,Logic in Computer Science (cs.LO) ,Artificial Intelligence (cs.AI) ,Artificial Intelligence ,Explainable AI ,Neural and Evolutionary Computing (cs.NE) ,Neural networks - Abstract
International audience; The large and still increasing popularity of deep learning clashes with a major limit of neural network architectures, that consists in their lack of capability in providing human-understandable motivations of their decisions. In situations in which the machine is expected to support the decision of human experts, providing a comprehensible explanation is a feature of crucial importance. The language used to communicate the explanations must be formal enough to be implementable in a machine and friendly enough to be understandable by a wide audience. In this paper, we propose a general approach to Explainable Artificial Intelligence in the case of neural architectures, showing how a mindful design of the networks leads to a family of interpretable deep learning models called Logic Explained Networks (LENs). LENs only require their inputs to be human-understandable predicates, and they provide explanations in terms of simple First-Order Logic (FOL) formulas involving such predicates. LENs are general enough to cover a large number of scenarios. Amongst them, we consider the case in which LENs are directly used as special classifiers with the capability of being explainable, or when they act as additional networks with the role of creating the conditions for making a black-box classifier explainable by FOL formulas. Despite supervised learning problems are mostly emphasized, we also show that LENs can learn and provide explanations in unsupervised learning settings. Experimental results on several datasets and tasks show that LENs may yield better classifications than established white-box models, such as decision trees and Bayesian rule lists, while providing more compact and meaningful explanations.
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- 2023
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48. Forward Approximate Solution for Linear Quadratic Tracking
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Betti, Alessandro, Casoni, Michele, Gori, Marco, Université Côte d'Azur (UCA), Modèles et algorithmes pour l’intelligence artificielle (MAASAI), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Laboratoire Jean Alexandre Dieudonné (LJAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Ingegneria dell'informazione e scienze matematiche [Siena] (DIISM), and Università degli Studi di Siena = University of Siena (UNISI)
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Optimization and Control (math.OC) ,FOS: Mathematics ,[MATH]Mathematics [math] ,Mathematics - Optimization and Control - Abstract
In this paper, we discuss an approximation strategy for solving the Linear Quadratic Tracking that is both forward and local in time. We exploit the known form of the value function along with a time reversal transformation that nicely addresses the boundary condition consistency. We provide the results of an experimental investigation with the aim of showing how the proposed solution performs with respect to the optimal solution. Finally, we also show that the proposed solution turns out to be a valid alternative to model predictive control strategies, whose computational burden is dramatically reduced., 14 pages, 1 figure, 3 tables
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- 2023
49. A Broadband Low-Profile Circularly Polarized Radial Line Slot Antenna
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Matthieu Bertrand, Mauro Ettorre, Guido Valerio, Matteo Albani, M. Casaletti, Thales Research and Technology [Palaiseau], THALES [France], Laboratoire Génie électrique et électronique de Paris (GeePs), CentraleSupélec-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Department of Information Engineering [Sienne] (DII), Università degli Studi di Siena = University of Siena (UNISI), and ANR-16-ASTR-0001,Fast-HEM-3DSIW,Modélisation hybride ultra-rapide pour l'analyse de structures antennaires Substrate Integrated Waveguide 3D complexes intégrées(2016)
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[SPI]Engineering Sciences [physics] ,pillbox ,Electrical and Electronic Engineering ,leaky-wave antenna ,Radial Slot Line Antenna (RLSA) ,optimization - Abstract
International audience; This paper presents a circularly polarized Corporate-Fed Radial-Line Slot Antenna (CF-RLSA) operating in Ka-band and realized in low-cost, low-profile printed circuit board (PCB) technology. The radiating aperture is fed by a corporate feed network based on a broadband pillbox-like circular transition. The proposed feeding system results in a 67% gain bandwidth improvement compared to classical center-fed RLSA designs. Pattern stability versus frequency is also achieved. The bandwidth improvement provided by the corporate-feed topology is analytically derived for the general case of circular apertures with uniform amplitude illumination. This predicted improvement is confirmed by measurements. The prototype is optimized using a dedicated numerical tool, then fabricated and characterized. A good agreement is obtained between simulated and measured gain bandwidths, with a demonstrated relative bandwidth of 6.9% at 29 GHz for a maximum gain of 35.5 dBi and a 260 mm diameter for the radiating aperture.
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- 2023
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- View/download PDF
50. Disrupting immune regulation incurs transient costs in male reproductive function
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Romain Guerreiro, Gabriele Sorci, Bruno Faivre, Eugenio Paccagnini, Jérôme Bellenger, Virginia Belloni, Biogéosciences [Dijon] ( BGS ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Department Tropical Medicine, University of Tulane, Dipartimento di Biologia Evolutiva, Università degli Studi di Siena ( UNISI ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Financial support from the Région Bourgogne., Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Tulane University, Università degli Studi di Siena = University of Siena (UNISI), Lipides - Nutrition - Cancer (U866) (LNC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
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Genetics and Molecular Biology (all) ,0106 biological sciences ,Male ,medicine.medical_treatment ,lcsh:Medicine ,Biochemistry ,01 natural sciences ,Mice ,Monoclonal ,Receptors ,Testis ,[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology, environment/Symbiosis ,[ SDV.IMM ] Life Sciences [q-bio]/Immunology ,Receptors, Interleukin-10 ,Animals ,Antibodies, Monoclonal ,Body Weight ,Inflammation ,Organ Size ,Reproduction ,Spermatozoa ,Immunomodulation ,Medicine (all) ,Biochemistry, Genetics and Molecular Biology (all) ,Agricultural and Biological Sciences (all) ,lcsh:Science ,Receptor ,Immune Response ,0303 health sciences ,Multidisciplinary ,Reproductive function ,Aging and Immunity ,Interleukin-10 ,3. Good health ,Cytokine ,Cytokines ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,medicine.symptom ,Research Article ,Infertility ,Evolutionary Immunology ,Immunology ,Biology ,010603 evolutionary biology ,Immune Suppression ,Antibodies ,03 medical and health sciences ,Immune system ,Immunity ,medicine ,030304 developmental biology ,Evolutionary Biology ,[ SDE.BE ] Environmental Sciences/Biodiversity and Ecology ,lcsh:R ,Immunoregulation ,medicine.disease ,Blockade ,Immune System ,Humoral Immunity ,lcsh:Q ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,[SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis - Abstract
9 pages; International audience; BACKGROUND: Immune protection against pathogenic organisms has been shown to incur costs. Previous studies investigating the cost of immunity have mostly focused on the metabolic requirements of immune maintenance and activation. In addition to these metabolic costs, the immune system can induce damage to the host if the immune response is mis-targeted or over-expressed. Given its non-specific nature, an over-expressed inflammatory response is often associated with substantial damage for the host. Here, we investigated the cost of an over-expressed inflammatory response in the reproductive function of male mice. METHODOLOGY/PRINCIPAL FINDINGS: We experimentally blocked the receptors of an anti-inflammatory cytokine (IL-10) in male mice exposed to a mild inflammatory challenge, with each treatment having an appropriate control group. The experiment was conducted on two age classes, young (3 month old) and old (15 month old) mice, to assess any age-related difference in the cost of a disrupted immune regulation. We found that the concomitant exposure to an inflammatory insult and the blockade of IL-10 induced a reduction in testis mass, compared to the three other groups. The frequency of abnormal sperm morphology was also higher in the group of mice exposed to the inflammatory challenge but did not depend on the blockade of the IL-10. CONCLUSIONS: Our results provide evidence that immune regulation confers protection against the risk of inflammation-induced infertility during infection. They also suggest that disruption of the effectors involved in the regulation of the inflammatory response can have serious fitness consequences even under mild inflammatory insult and benign environmental conditions.
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- 2014
- Full Text
- View/download PDF
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