49 results on '"Uchida, N."'
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2. Temporal variation of intermediate-depth earthquakes around the time of the M9.0 Tohoku-oki earthquake
- Author
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Delbridge, BG, Kita, S, Uchida, N, Johnson, CW, Matsuzawa, T, and Bürgmann, R
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Meteorology & Atmospheric Sciences - Abstract
©2017. American Geophysical Union. All Rights Reserved. The temporal evolution of intermediate-depth seismicity before and after the 2011 M9.0 Tohoku-oki earthquake reveals interactions between plate interface slip and deformation in the subducting slab. We investigate seismicity rate changes in the upper and lower planes of the double seismic zone beneath northeast Japan using both a β statistic approach and a temporal epidemic type aftershock sequence model. We do not observe an anomalous precursory increase in intermediate-depth earthquake activity preceding the mainshock; however, following the mainshock, we observe a rate increase for the intermediate-depth earthquakes in the upper plane. The average ratio of upper plane to lower plane activity and the mean deep aseismic slip rate both increased by factor of 2. An increase of downdip compression in the slab resulting from coseismic and postseismic deformation enhanced seismicity in the upper plane, which is dominated by events accommodating downdip shortening from plate unbending.
- Published
- 2017
3. Ezetimibe added to statin therapy after acute coronary syndromes
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Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, Podczeck-Schweighofer, A, Priesnitz, T, Frank, H, El Allaf, D, Marechal, P, Roosen, J, Joly, E, Lefebvre, P, Arend, C, Sinnaeve, P, De Velder, L, Hellemans, S, Vanhauwaert, B, Van Dorpe, A, Heyse, A, Vantomme, C, Striekwold, H, Van Den Broeck, D, Lancellotti, P, Schoors, D, Lemoine, I, Taeymans, Y, De Wolf, L, Brike, C, Vercauteren, S, Tahon, S, Vervoort, G, Mestdagh, I, Pirenne, B, Cardinal, F, Lips, S, Dujardin, K, Debrouwer, K, Dhooghe, G, Holvoet, G, van de Borne, P, Renard, M, De Clippel, M, Lesseliers, H, Van Miert, N, Saraiva, J, Vicente, C, Rossi, P, Dos Santos LB, Duda, N, Tognon, Ap, Serrano, C, Gomes, Fl, Manenti, Er, Silveira, Ds, Maia, L, Mouco, Om, Paiva, M, Antonangelo, A, de Souza, J, Lino, Ea, Leães, P, Blacher, Mg, Kormann, A, Ultramari, Ft, Dutra, O, Mendelski, Am, Morgado, S, Ardito, W, Greque, G, Ardito, Rv, Pimentel Filho, P, Zucchetti, C, Alves, A, Seabra, Am, Mattos, M, Miranda, Lf, Silva, D, Uehara, Rm, Marin Neto, J, Schmidt, A, Braga, J, Rodrigues, A, Abrantes, J, Pinheiro, L, Bodanese, L, Magedanz, Éh, Piegas, L, Dos Santos ES, Wainstein, M, Ribeiro, J, Stein, R, Marino, R, Machado, Vm, Moraes Junior, J, Guimarães, S, da Costa FA, Ferraz, Rf, Albuquerque, D, Rocha, Rm, de Carvalho Moreira, R, Dohmann, H, Costantini, C, Tarastchuk, Jc, Coelho, O, Cirillo, W, Sousa, A, Almeira, As, Stefanini, E, Silva, F, Teixeira, M, da Cunha, C, Précoma, D, Facchi, Tl, Rupka, D, Thiessen, S, Warnica, J, Smith, B, Della Siega, A, Klinke, P, Nelson, S, Dion, D, Gilbert, N, Hui, W, Kvill, L, Sussex, B, Luther, A, Dupuis, R, Ouimet, F, Pandey, A, Clarus, S, Senaratne, M, Ferdinandis, H, Mukherjee, A, Bozek, B, Vizel, S, Markov, G, Zimmermann, R, Stephens, W, Tremblay, B, Wong, G, Uchida, N, Brossoit, R, Peck, C, Van Kieu, C, Forgione, M, Bata, I, Cossett, J, Kostuk, W, Arnold, M, Bone, C, Grondin, F, Bilodeau, N, Gosselin, G, David, M, Giannoccaro, J, Beresford, P, Polasek, P, Roberts, P, Doucet, M, Beaudry, M, Cheung, S, Cleveland, T, Bhargava, R, Mccallum, A, Ma, P, Morrissette, J, Cleveland, D, Chadwyn, D, Nigro, F, Weeks, A, Cryderman, C, Leader, R, Houde, G, Rousseau, S, Pearce, M, Radyk, M, Lonn, E, Magi, A, Lefkowitz, C, Sandrin, F, Coffin, N, Lubelsky, B, Coldwell, J, Habot, J, Mcpherson, C, De Larochelliere, R, Roy, M, Haichin, R, Barber, C, Bhesania, T, Kitagawa, H, To, T, Donnelly, B, Tymchak, W, Harris, L, Kouz, S, Huynh, T, St Jacques, B, Lamy, A, Rizzo, A, Stein, J, Childs, C, Wong, B, Poirier, R, Gupta, M, Dela Cruz, C, Constance, C, Gauthier, M, Ervin, F, Ouellette, M, Kokis, A, Lemay, C, Kwok, K, Leung, C, Lee, D, Nesmith, J, Renton, J, Syan, G, Turek, M, Hogan, D, Griffin, P, Lipson, A, Winestock, J, Abramson, B, Fogel, A, Gagne, C, Bergeron, J, Clarke, A, Slipp, S, Darcel, I, Carling-Chambers, L, Kannampuzha, P, Pallie, S, Krekorian, S, Vertes, G, Roth, S, Lai, K, Heath, J, Perez, L, Arriagada, G, Castro, P, Villa, F, Rodríguez, M, Ramos, G, Baraona, F, Núñez, A, García, M, Jofre, C, Silva, P, Lamich, R, Yovaniniz, P, Escobar, E, Dussaubat, A, Segura, E, Ramirez, M, Lapostol, C, Palma, A, Encina, L, Zapata, M, Baeza, N, Varela, P, Pérez, L, Jaramillo, C, Ruiz, S, Sanchez, G, Perdomo, I, Manzur, F, Cohen, Le, Velasquez, J, Arana, C, Alvarez, Y, Triana, M, Balaguera, J, de Salazar, D, Rendon, N, Botero, R, Ruiz, A, Saaibi, J, Medina, J, Jaramillo, M, Calderón, Mj, Delgado, J, Bohorquez, R, Medina, Mf, Herrera, M, Rosales, D, Mendoza, F, Martinez, S, Ternera, A, Castro, R, Baiz, A, Martinez, M, Orozco, A, Suarez, M, Fonseca, Y, Beltran, R, Cepeda, M, Jaramillo, N, Valenzuela, C, Gutierrez, M, Sanchez, A, Vitovec, J, Hlinomaz, O, Poloczek, M, Mayer, O, Veselka, J, Vejvoda, J, Soucek, M, Spac, J, Novobilsky, K, Srp, V, Francek, L, Branny, M, Sknouril, L, Motovska, Z, Rohac, F, Stankova, A, Fiala, T, Holub, M, Zeman, K, Pohludkova, L, Pospisilova, E, Tuma, P, Cihalik, C, Oral, I, Podpera, I, Stepanovova, R, Uricar, M, Solar, M, Pelouch, R, Porzer, M, Grussmannova, K, Stipal, R, Reichert, P, Hradec, J, Kral, J, Sejkova, B, Janek, B, Pitha, J, Linhart, A, Polacek, P, Koeber, L, Clemmensen, P, Hebin, Ch, Schmidt, E, Pedersen, Ms, Roseva-Nielsen, N, Kristensen, K, Bang-Hansen, T, Jensen, J, Laage-Petersen, J, Nielsen, H, Stokholm, E, Thayssen, P, Cappelen, H, Jensen, T, Winther-Friis, B, Klausen, I, Hedegaard, B, May, O, Andersen, M, Bottzauw, J, Lush, A, Markenvard, J, Vestager, Km, Bronnum-Schou, J, Hempel, H, Petersen, J, Nielsen, Aj, Thomsen, K, Nielsen, T, Nygaard, A, Sykulski, R, Jensen, Bs, Ralfkiaer, N, Gottschalck, H, Rasmussen, S, Pedersen, Lr, Dodt, K, Skovsbøl, M, Andersen, O, Tuxen, C, Meier, Aw, Kristensen, T, Rasmussen, O, Lopez, J, Salazar, D, Sanchez, L, Rosero, F, Penaherrera, E, Duarte, Yc, Marmol, R, Andrade, G, Guzman, E, Morillo, A, Aug, L, Loogna, I, Laanmets, P, Mustonen, J, Mäntylä, P, Kesäniemi, A, Ukkola, O, Kervinen, H, Juhela, S, Juvonen, J, Toppinen, A, Jarvenpaa, J, Syvanne, M, Svahn, T, Voutilainen, S, Huotari, A, Nikkila, M, Raiskinmäki, S, Kotila, M, Rajala, A, Laukkanen, J, Hiltunen, P, Melin, J, Nyman, K, Luukkonen, J, Kosonen, P, Huttunen, M, Seppänen, V, Airaksinen, J, Juonala, M, Lehto, S, Savolainen, K, Halkosaari, M, Sia, J, Palomaki, A, Luoma, J, Utriainen, S, Valpas, S, Tiensuu, T, Lilleberg, J, Kainulainen, R, Schiele, F, Bassand, J, Meneveau, N, Galinier, M, Jean, M, Martelet, M, Mouallem, J, Elbaz, M, Puel, J, Carrié, D, Coisne, D, Varroud-Vial, N, Jaboureck, O, Dujardin, J, Leroy, F, Mansourati, J, Funck, F, Jourdain, P, Guillard, N, Coviaux, F, Gay, A, Dourmap-Collas, C, Froger-Bompas, C, Paillard, F, Tricot, O, Maquin-Mavier, I, Dubois-Rande, Jl, Pongas, D, Paris, Ap, Delahaye, F, Ovize, M, Benyahya, L, Bonnet, J, Belle, L, Mangin, L, Lafitte, B, Zemour, G, Doux, N, Agraou, B, El Mansour, N, Traisnel, G, El Jarroudi, M, Ohlmann, P, Diadema, B, Escande, M, Legros, G, Demarcq, Jm, Haftel, Y, Alsagheer, S, Dambrine, P, Cottin, Y, Ghostine, S, Caussin, C, Gacem, A, Bouvier, Jm, Poulard, J, Davy, J, Furber, A, Prunier, F, Muenzel, T, Genth-Zotz, S, Appel, K, Kretzschmar, D, Ferrari, M, Terres, W, Uher, T, Schulze, H, Ochs, H, Morbach, S, Duengen, H, Gross, M, Oezcelik, C, Tahirovic, E, Heuer, H, Laschewski, B, Kadel, C, Rahn, G, Steiner, S, Kreuzer, J, Tsoy, I, Zeiher, A, Muegge, A, Hanefeld, C, Boehm, S, Boudriot, E, Hodenberg, E, Lippe, B, Hausdorf, C, Sydow, K, Baldus, S, Schlesner, C, Tiroch, K, Haltern, G, Guelker, H, Wilhelm, J, Dietz, S, Ebelt, H, Buerke, M, Rupprecht, H, Rittgen, J, Schaeufele, T, Meinhardt, G, Schieber, M, Honold, M, Sieprath, S, Nienaber, C, Hacker, J, Butter, C, Lapp, H, Hirn, S, Pauschinger, M, Zahn, R, Scheffler, U, Schaefer, A, Schieffer, B, Tebbe, U, Kriete, M, Mudra, H, Raeder, T, Braun, P, Zeymer, U, Kouraki, K, Reppel, M, Schunkert, H, Weil, J, Olbrich, H, Schwaiger, P, Mueller, O, Blessing, E, Buss, I, Bohlscheid, V, Kaddatz, J, Skowasch, D, Nickenig, G, Twelker, K, Osterhues, H, Varghese, T, Burghard, S, Kaeaeb, S, Klauss, V, Sohn, Hy, Hauptmann, K, Schulze, M, Gall, K, Felix, S, Doerr, M, Mante, J, Gulba, D, Freick, M, Werner, G, Kleinertz, K, Hobbach, Hp, Halbach, M, Mueller-Ehmsen, J, Mueller, Me, Mitrovic, V, Peil, A, Laufs, U, vom Dahl, J, Baumanns, S, Scholtz, W, Wiemer, M, Haude, M, Van de Loo, A, Pistorius, K, Schaefer, J, Schwinger, R, Goeing, O, Jung, W, Birkemeyer, R, Lee, W, Kong, S, Yu, C, Chui, K, Merkely, B, Szelényi, Z, Polgár, P, Svab, S, Herczeg, B, Bajcsi, É, Vértes, A, Davidovits, S, Nagy, A, Király, C, Lupkovics, G, Kenéz, A, Poór, F, Takács, J, Kirschner, R, Simonyi, G, Koncz, J, Édes, I, Gergely, S, Katona, A, Nagy, E, Kovács, Z, Gyetvai, I, Salamon, C, Kolman, É, Sitkei, É, Csapó, K, Molnar, K, Mező, I, Sereg, M, Reddy, P, Manjunath, C, Narayanappa, S, Kumar, S, Sinha, N, Kapoor, A, Christopher, J, Reddy, G, Rani, M, Oomman, A, Ramamurthee, K, Kumar, N, Pasha, Ss, Rao, C, Murty, Gs, Chopra, A, Kapila, D, Bali, H, Chattree, K, Hasan, O, Suryaprakash, G, Rao, D, Babu, R, Bhargavi, M, Naik, S, Khan, S, Chopra, V, Sapra, R, Kaul, U, Ghose, T, Menon, R, Battikadi, S, Mullasari, A, Subban, Vk, Dani, S, Iby, M, Chandra, P, Sethi, S, Bhargava, M, Arora, P, Tyagi, G, Padmanabhan, T, Malhotra, S, Talwar, K, Shafiq, N, Kasliwal, R, Bansal, M, Eldar, M, Berger, M, Shechter, M, Atar, S, Roguin, N, Kilimnik, M, Hayek, T, Hamoud, S, Katz, A, Plaev, T, Shotan, A, Vazan, A, Weiss, A, Leibowitz, D, Zimlichman, R, Ben-Aharon, J, Hammerman, H, Dragu, R, Rozenman, Y, Witzling, V, Tzivoni, D, Moriel, M, Halkin, A, Sheps, D, Bogomolny, N, Mosseri, M, Khudyak, Y, Halabi, S, Uziel-Iunger, K, Yuval, R, Shimoni, S, Caspi, A, Botwin, S, Gavish, D, Sandler, A, Pollak, A, Kreisberg, B, Hussein, O, Jabal, K, Henkin, Y, Grosbard, A, Rosenschein, U, Rivlin, E, Zeltser, D, Platner, N, Porter, A, Harel, N, Lishner, M, Elis, A, Karny, M, Fuchs, S, Stein, G, Grossman, E, Gealel, Z, Schlaeffer, F, Liberty, I, Golik, A, Tzuman, O, De Ferrari, G, Pavesi, C, Poggio, L, Damiano, S, Pazzano, As, Mennuni, M, Paloscia, L, Mascellanti, M, Piovaccari, G, Grosseto, D, Mascia, F, Vetrano, A, Zingarelli, A, Mazzantini, S, Visconti, L, Terzi, G, Senni, M, Gavazzi, A, Scuri, P, Carmelo, M, De Caterina, R, Conti, M, Novo, S, Graceffa, A, Arvigo, L, Lunetta, M, Filardi, P, Chiariello, M, Scala, O, Pirozzi, E, Musella, F, Moretti, L, Testa, M, Vicentini, A, De Feo, S, Biasucci, L, Cardillo, Mt, Puccioni, E, Galli, M, Menegato, A, Margheri, M, Maresta, A, Gatti, C, Guarini, P, Damiano, M, Golino, P, Porcu, M, Fele, N, Gensini, G, Lombardi, A, Ciuti, G, Bernardi, D, Mariani, P, Paolini, E, Marenzi, G, Moltrasio, M, Terrosu, P, Chessa, P, Guglielmino, G, Miccoli, F, Oldoino, E, Ragni, M, Poli, M, Basso, V, Rapezzi, C, Branzi, A, Gallelli, I, Perna, G, Guazzarotti, F, Marra, S, Usmiani, T, Olivari, Z, Calzolari, D, Santoro, G, Minneci, C, Achilli, A, Nassiacos, D, Sommariva, L, Romeo, F, Fedele, Francesco, Mancone, Massimo, Foschi, Ml, Bruno, N, Centurion, C, Patrizi, G, De Maria, E, Gonnelli, S, Vichi, V, Cassadonte, F, Rotella, G, Capucci, A, Villani, G, Gaspardone, A, Ferrante, R, Scollo, V, Pancaldi, L, Saccà, S, Gabrielli, D, Ciliberti, D, Savini, E, Binaghi, G, Di Biase, M, Ieva, R, Fattore, L, Cicia, G, Cavallini, C, Tamburino, C, Sacco, A, Mafrici, A, Di Pasquale, G, Pavesi, Pc, Scioli, R, Lioy, E, Occhiuzzi, E, Matino, Mg, Russo, V, Moscogiuri, Mg, Cuccia, C, Forgione, C, Volpe, M, Palano, F, Branca, G, Rossi, R, Modena, M, Olaru, Ia, Zanini, R, Cianflone, D, Cristell, N, Pantaleoni, M, Guiducci, U, Menozzi, C, Gaddi, O, Fasulo, A, Indolfi, C, Emanuele, V, Guerra, F, Iliceto, S, Marotta, C, Morocutti, G, Presbitero, P, Rossi, M, Bonatti, S, Grieco, A, Chiodi, L, Betti, I, Zuppiroli, A, Fanelli, R, Stanco, G, Azzolini, P, Ruggieri, C, Bocconcelli, P, Airoldi, F, Tavano, D, Brunelli, C, Caso, P, Scalzone, A, Ghigliotti, G, Facciorusso, A, Sim, K, Kiam, O, Chee, K, Bin Ismail, O, Zambahari, R, Ophuis, T, van Nes, E, Werter, Cj, Ophuis, Aj, Troquay, Rp, Hamer, Bj, Lenderink, T, Feld, Rj, van Hessen MW, Viergever, Ep, van der Sluis, A, Lok, Dj, Badings, Ea, Nierop, Pr, Danse, Iy, Hermans, Wr, Holwerda, Nj, Thijssen, Hj, Theunissen, Lj, van der Zwaan, C, Van Den Berg BJ, Hendriks, Ih, Ronner, E, Withagen, Aj, Dijkshoorn-Giesen, Ah, Ezechiels, Jp, Kuijper, Af, Den Hartog FR, Van Kalmthout PM, Buijs, Em, van der Zeijst, M, Zwart, Pa, Zuidgeest, Ja, van Eck, M, Daniels, Mc, van der Ven-Elzebroek, N, Van 't Hof, A, van Boven AJ, van der Weerdt, A, Dunselman, Ph, Alings, Ma, van Es RF, The, Sh, Gurlek, C, Liem, Ah, van Lennep HW, Van Vlies, B, Kalkman, C, Swart, Hp, van der Bij, P, Taverne, R, Ciampricotti, R, van Dam, C, Spierenburg, H, van Ruijven, I, van Kempen LH, Willems, Ff, Dirkali, A, Stoel, I, Plomp, J, Veldmeijer, S, Tjeerdsma, G, Nijmeijer, R, Van Hal JM, Bartels, Gl, Posma, Jl, Linssen, Gc, Fauser, Cg, Waalewijn, Ra, Groenemeijer, Be, Pos, L, Fast, Jh, Droste, Ht, Westenburg, J, Veenstra, W, Koolen, J, van Loo LW, Smits, W, Milhous, Jg, van Rossum, P, Stuij, S, Scott, R, Richards, Am, Morrison, Z, Devlin, G, Fisher, R, Stewart, R, Benetar, J, Voss, J, Wong, S, Scott, D, Luke, R, Tang, E, Davidson, L, Hamer, A, Wilson, S, Price, R, Hart, H, Turner, A, Jortveit, J, Calic, S, Gundersen, T, Brunvand, H, Fosse, L, Nygaard, O, Gjellefall, B, Gravdal, Sa, Ringstad, R, Atar, D, Clausen, H, Hysing, J, Arvesen, K, Topper, M, Flagstad, E, Graven, T, Haug, Hh, Dalin, L, Al-Ani, R, Otterstad, J, Ausen, K, Aaser, E, Olufsen, M, Halvorsen, S, Gullestad, L, Stueflotten, W, Waage, K, Stødle, Rm, Hall, C, Aase, O, Nordeng, J, Soyland, E, Fageraas, Er, Lied, A, Aske, R, Raouf, N, Johansson, J, Herrscher, T, Skogrand, E, Bjornstad, H, Aagnes, I, Arntsen, Bi, Vegsundvaag, J, Skjold, Me, Velle, H, Aambakk, Mb, Skjetne, O, Byfuglien, A, Rodriguez, J, Galvez, D, Medina, F, Hernandez, Ha, Chavez, V, Morales, R, Huapalla, E, Velasquez, D, Torres, F, Aguirre, O, Yanez, L, Andrade, M, Campos, C, Arce, R, Mogrovejo, W, Osores, F, Bustamante, G, Rodriguez, M, Berrospi, P, Garcia, C, Talledo, M, Navarro, P, Horna, M, Herrera, V, Kadziela, J, Rybicka-Musialik, A, Trusz-Gluza, M, Berger-Kucza, A, Musial, W, Tycinska, A, Gil, R, Gziut, A, Gorny, J, Tyllo, M, Reszka, Z, Mickiewicz-Pawlowska, M, Wrzosek, B, Kosior, J, Staneta, P, Korzeniak, R, Kalarus, Z, Markowicz, E, Miekus, P, Konarzewski, M, Kleinrok, A, Puzniak, M, Grajek, S, Janus, M, Krzyzanowski, M, Hoffmann, A, Muzalewski, P, Polonski, L, Kazik, A, Nowalany-Kozielska, E, Wojciechowska, C, Ponikowski, P, Nawrocka, S, Filipiak, K, Serafin, A, Dubiel, J, Mielecki, W, Ogorek, M, Kopcik, D, Jaworska, K, Skonieczny, G, Kawecka-Jaszcz, K, Bryniarski, L, Tracz, W, Lesniak-Sobelga, A, Jankielewicz, J, Zaluska, R, Trojnar, R, Kawalek, P, Gaciong, Z, Pulkowski, G, Anaszewicz, M, Samul, W, Adamus, J, Cholewa, M, Kubik, L, Szczechowicz, R, Rekosz, J, Kwiatkowska, D, Gajek, J, Mazurek, W, Kominek, M, Siminiak, T, Guzniczak, E, Monteiro, P, Providencia, L, Monteiro, S, Pinho, T, Gavina, C, Sousa, C, Loureiro, J, Ferreira, Ar, Cardoso, A, Araujo, J, Rebolo, I, Catarino, C, Santos, J, Nunes, Lp, Mimoso, J, Marques, N, Leitao, M, Pais, J, Fernandes, A, Diogo, A, Nóbrega, J, Moreira, Ji, Mateus, P, Oliveira, J, Selas, M, Ribeiro, V, Albuquerque, A, Reis, R, Ramos, A, Salazar, F, Nair, D, Ng, Ck, Yeo, D, Wong, A, Funiak, S, Belicova, M, Striezova, I, Krajci, P, Sojka, G, Herman, O, Zemberova, A, Pella, D, Fedacko, J, Banikova, A, Micko, K, Macek, V, Moscovic, M, Vahala, P, Vykoukalova, T, Dzupina, A, Marusakova, M, Stevlik, J, Akubzanova, E, Hatalova, K, Burgess, L, Coetzee, C, Mabin, T, Roos, J, Mohamed, Z, Pillay, T, Corbett, C, Bodenstein, W, Tayob, F, Ebrahim, I, Bolsman, C, Horak, A, Lloyd, E, Pretorius, M, Commerford, P, De Andrade, M, Roux, J, Murray, A, Soma, P, Delport, E, Cassel, G, Van Zyl, L, Cronje, T, Sarvan, M, Moodley, R, Guerra, M, Swanepoel, N, Bayat, J, Klug, E, Hellig, S, Yoon, J, Kim, J, Chung, W, Choi, Y, Cho, M, Lee, S, Kwon, H, Hong, B, Seung, K, Chang, K, Rha, S, Jeong, Mh, Hong, Y, Lee, C, Seong, I, Jeong, J, Tahk, S, Yoon, M, Chae, Sc, Kim, H, Lopez, V, Roldan, Jm, Mancisidor, P, Froufe, J, López, A, Franco, S, Molina, A, Soriano, F, Cobos, M, Mejía, Hd, Sanz, R, Vazquez, A, Garri, F, Esteban, I, Marco, P, Artaecheverria, J, Cequier, A, Esplugas, E, Gonzalez, J, de Sa, E, Armada, E, Worner, F, Hernández, I, Roncales, F, Gomollon, J, del Rio, A, Alameda, J, Basilio, E, Rafols, M, Ferres, R, Molla, C, Pascual, J, Cortada, J, García, C, Iglesias, G, Villa, E, Aros, F, Goya, I, Bueno, M, Pereira, Rv, Clavero, X, Pasaron, Cd, Jorda, R, Pereira, R, Perez, O, de Teresa, E, Navarro, M, de la Guia, F, Lozano, T, Antorrena, I, Aranda, M, Alonso, L, Mirelis, J, Alcasena, S, Paniagua, Va, Juanatey, J, Gregorian, L, Munoz, J, Escorihuela, A, Sanz, A, Flores, A, Garcia, Pa, Alfonso, F, Marin, E, Lozano, A, Bethencourt, A, Grau, A, Rubio, A, Sala, J, Royuela, N, San Jose, J, Bugos, V, de Valdecilla, H, Martin, J, Jimenez, R, Felgueres, M, Escalera, P, Ruiz, R, Bescos, L, Sanchez, I, Chavarri, M, Casares, G, Johanson, P, Hultsberg-Olsson, G, Witt, N, Samad, B, Damm, T, Risenfors, M, Ortgren, L, Henareh, L, Jernberg, T, Berglund, M, Karlsson, J, Koch, A, Lycksell, M, Lundgren, C, Herlitz, J, Sjölin, M, Erlinge, D, Matson, E, Cizinsky, S, Carlsson, F, Ryttberg, B, Johansson, K, Tygesen, H, Bergsten, J, Naslund, U, Sundholm, C, Timberg, I, Wikström, P, Hårdhammar, P, Lisbeth, A, Lund, L, Hage, C, Rosenqvist, U, Grändås, M, Larsson, L, Hammerman, A, Andersson, G, Johansson, S, Bennermo, M, Tjerneld, H, Forsgren, M, Eriksson, K, Eriksson, M, Bengtsson, Po, Yu, W, Ceder-Brolin, K, Stafberg, C, Andersson, E, Roussine, V, Ångman, K, Melin, B, Thorsen, S, Lundell, L, Buijs, F, Östberg, S, Sigaud, P, Moccetti, T, Bondio, M, Kuehlkamp, V, Pieper, M, Gallino, A, Zender, H, Genné, D, Gauthey, J, Wilhelm, M, Saner, H, Trachsel, L, Roethlisberger, C, Schlaepfer, H, Kujawski, T, Pagnamenta, A, Meyer-Monard, S, Krapf, R, Biedermann, B, Schneider, H, Rickli, H, Ramsay, D, Linka, A, Ballmer, P, Oswald, M, Girod, G, Charng, M, Shu-Ling, H, Ping-Han, L, Wu, C, Liu, S, Lin, M, Chian-Yi, W, Yeh, H, Mei-Juan, C, Hsieh, I, Wang, Y, Ural, E, Sahin, T, Yildiz, Z, Kayikcioglu, M, Kultursay, H, Yigit, Z, Calpar, I, Ata, N, Goktekin, O, Senol, U, Yalcin, R, Timurkaynak, T, Kaya, U, Yildirir, A, Karacaglar, E, Faynyk, A, Sorokivskyy, M, Koval, O, Kaplan, P, Kraiz, I, Popova, K, Kyyak, Y, Barnett, O, Karpenko, O, Todoriuk, L, Tseluyko, V, Kopytsya, M, Petyunina, O, Kovalskyy, I, Zhukova, Y, Katerenchuk, I, M'Yakinkova, L, Lutay, Y, Syvolap, V, Kyselov, S, Vakaliuk, I, Nesterak, R, Nikonov, V, Feskov, O, Goloborodko, B, Golovtsev, Y, Berezniakov, I, Lebedynska, M, Rudenko, L, Tutov, I, Ahsan, A, Burton, J, Levy, T, Lakeman, N, Spratt, J, Langford, E, Sutcliffe, S, Khwanda, A, Davis, G, Rodrigues, E, Dickinson, D, Been, M, Trouton, T, Riddell, J, Moriarty, A, Mceneaney, D, Squire, I, Narayan, H, Goode, G, Helliwell, L, Boos, C, Greaves, K, Knops, K, Pegge, N, Signy, M, Wong, Y, Moore, S, Fluck, D, Atkinson, C, Adgey, A, Mckeag, N, Bishop, A, Glover, J, Barbir, M, Breen, J, Robson, H, Townend, J, Dwenger, E, Ekpo, E, Shakespeare, C, Barr, C, Mcclements, B, Mcallister, A, De Belder, M, Cooke, J, Williams, S, Daniel, D, Pye, M, Griffith, K, Wright, L, Trevelyan, J, Doughty, A, Hughes, E, Phillips, C, Penny, W, Groves, P, Kardos, A, Purvis, J, Mcneill, A, Jones, A, Brown, J, Saeed, B, Sprigings, D, Herity, N, Brown, C, Unks, M, Cauthren, T, Bertolet, B, Jones, M, Decker, S, Chambers, J, Stahlberg, J, Varma, S, Gencheff, N, Price, A, Mcelroy, D, Chu, A, Crutchfield, B, Eaton, G, Looney, A, Qureshi, M, Wilks, J, Drenning, D, Overman, A, Andreou, C, Russo, P, Stuckey, T, Pruitt, H, D'Urso, M, Deraad, R, Rogers, W, Thorington, S, Pasquini, J, Iwaoka, R, Tannenbaum, M, Prouty, D, Wiseman, A, Sharow, A, Graham, B, Ali, Mi, Dale, H, Tarsi, D, Picone, M, Juarez, S, Hamroff, G, Hollenweger, L, Scirica, B, Sabatine, M, Marti, J, Perlman, R, Pavlides, A, Joffe, I, Albirini, A, Campbell, T, Puri, S, Lopez, C, Pearce, D, Shah, D, Mcpherson, J, Donegan, R, Murdock, D, Block, D, Malik, A, Musina, R, Dauber, I, Varner, C, Bach, R, Palazzolo, M, Bhalla, H, Thompson, M, Pollock, S, Johnson, S, Lipson, L, Brunk, S, Karas, S, Vicari, R, Kuvin, J, Mooney, P, Aycock, G, Lane, B, Sharma, M, Gibson, T, Chang, G, Divito, P, Mehta, R, Watkins, K, Chiu, A, Gunderson, J, Tedder, B, Williams, P, Hage-Korban, E, Childs, A, Banerjee, S, Kazi, F, Bennett, J, Barnes, D, Wohns, D, Noorman, C, Aggarwal, K, Lau-Sickman, A, Paulowski, J, Amos, M, Rider, J, Fenton, S, Schantz, M, Hakas, J, Mcsorley, J, Felten, W, Bitzer, V, Russell, J, Loyo, J, Adjei, A, Mehta, K, Uretsky, B, Hale, M, Shaikh, S, Miller, M, Hollenbaugh, D, Crawford, K, Fortuin, D, Galindo, A, Del Core, M, Butkus, E, Collins, J, Prior, J, Hahn, R, Greene-Nashold, J, Alexander, J, Genova, E, Macdonell, A, Broadwater, S, Kereiakes, D, White, D, Lopez, M, Schenks, R, Lui, H, Gibbons, P, Davis, B, Thornton, K, Daley, P, Budzon, S, Mccullum, K, Delio-Cox, B, Nadar, V, Keim, S, Mclaurin, B, Davis, C, Betzu, R, Al-Jumaily, J, Bolli, R, Alshaher, M, Leesar, M, Collins, T, Akkad, H, Bilazarian, S, Marsters, M, Kennett, J, Melegrito, K, Mostel, E, Harris, R, Chang, M, Hatfield, G, Makam, S, Garvey, M, Levite, H, White, J, Abdel-Latief, A, Pelletier, L, Carr, K, Mckenna, K, De Lemos, J, Soto, G, Kozina, J, Harris, D, Vlastaris, A, Bittel, B, Riba, A, Gugudis, J, Singh, N, Qureshi, I, Doty, W, Lehmann, J, Lieber, I, Martin, S, Nicu, M, Bhalodkar, N, Ravi, P, Canto, J, Bass, M, Campbell, C, Steinhubl, S, Moles, K, Harjai, K, Stapleton, Dd, Hoey, K, Erwin, J, Fikes, W, Stein, B, Sabatino, K, Teklinski, A, Colfer, H, Ward, P, Langevin, E, Faucett, S, Mamdani, S, Desimone, L, Tuohy, E, Cullen, T, Eisenberg, S, Chronos, N, Allen, Rp, Erickson, B, Mahon, K, Kirby, A, Siegel, C, Stroud, L, Johnson, J, Panchal, V, Pearson, A, Abell, T, De Gregorio, M, Boomer, L, Vahdat, O, Vannatta, B, Long, P, Chalavarya, G, Skatrud, L, Carey, C, Wright, W, Mechem, C, Matthews, B, Adams, A, Vora, K, Wead, J, Koren, M, Gregory, D, El Khadra, M, Peacock, G, Kieval, J, Barron, M, Lewis, D, Grice, R, Bobek, M, Moore, C, Nygaard, T, Fischell, T, Salman, W, Schneider, C, Muhlestein, B, Peeler, D, Chang, D, Todd, A, Chilakamarri, V, Hanley, P, Gelormini, J, Iacona, Ma, Effron, B, Mazzurco, S, Mazzella, M, Wyman, P, Orchard, R, Battin, D, Rezkalla, S, Bishop, C, Sharp, S, Gredler, F, Knap, P, Fadel, M, Saucedo, J, Keng, A, Imburgia, M, Blank, E, Effat, M, Khoury, S, Mardis, R, Baldari, D, Tafuri, L, Mascolo, R, Taylor, D, Mandviwala, M, Khan, W, Mumford, T, Mayer, N, Mitchell, B, Oliver, T, Lombardi, W, Zimmerman, T, Rohrbeck, S, Cooke, L, Craig, M, Mego, D, Griffin, B, Perez, J, Leclerc, K, Addington, J, Aboufakher, R, Ahmed, A, Westecott, B, Steel, K, Hawkins, K, Shah, A, Ward, U, Mcgreevy, M, Goldberg, R, Prashad, R, Mcdonough, C, Silver, K, Josephson, R, Witsaman, S, Labib, S, Woodhead, G, Schrank, J, Bell, K, Chandna, H, Holly, D, Bethea, C, Fife, B, Gruberg, L, Singer, A, Ramgadoo, M, Lalonde, T, Morin, R, French, W, Barillas, O, Gradner, G, Kahn, Z, Gress, J, Rocco, D, Thew, S, Stifter, W, Fisher, M, Mcnamara, J, Kupfer, J, Agocha, A, Cush, S, Jones, S, Whitaker, T, Stover, T, Kumkumian, G, Kent, K, Greenberg, A, Pandey, P, Pytlewski, G, Matsumura, M, Kai, W, Sameshima, S, Thomas, J, Macnicholas, D, Pillai, K, Jones, D, Navas, Jp, Laskoe, B, Patel, P, Fini, G, Minor, S, Shipwash, T, Cabrera-Santamaria, A, Rivera, E, Mincher, L, Jafar, M, Yen, M, Finkle, C, Rahimtoola, A, Severson, L, Labroo, A, Jinich, D, Tam, K, Vogel, C, Aggarwal, R, Zakhary, B, Curtis, S, Lyster, M, Humphrey, K, Lavine, P, Fujise, K, Birnbaum, Y, Allen, J, Kesselbrenner, M, Michel, K, Staniloae, C, Liu, M, Sonel, A, Macioce-Caffas, A, Amidon, T, Leggett, J, Yedinak, S, Gudmundsson, G, Sabharwal, J, Dagefoerde, N, Wu, W, Meyerrose, G, Roongsritong, C, Jenkins, L, Lieberman, S, Sokol, S, Gutierrez, C, Nelson, C, Barrett, J, Hotchkiss, D, Farley, A, Atassi, K, Christy, L, Baig, M, Di Fazio, J, Meengs, M, Thomas, K, Surmitis, J, Devault, S, Farhat, N, Hulyalkar, A, Riddell, L, Rivera, W, Sheynberg, B, Kobayashi, J, Katsaropoulos, J, Jan, M, Krucoff, M, Paterno, C, Chandrasekaran, S, Curry, R, Cassavar, D, Wheeler, M, Mcgarvey, J, Schwarz, L, Miller, E, Andrea, B, Carswell, Bs, Lurie, M, Patti, J, Bowden, W, Vasiliauskas, T, Latham, R, Schwartz, B, Bradford, L, Mattleman, S, Wertheimer, J, Goulden, D, Khan, M, Hawkins, B, Ostfeld, R, Mueller, H, Ash, Y, Wilson, V, Bayer, M, Marshall, J, Dobies, D, Dawson, G, Osman, A, Saba, F, Costello, T, Fuentes, F, Underwood, C, Vijay, N, Washam, M, Dietz, W, Glasgow, B, Mukherjee, S, Hinchion, N, Speirs, S, Thornley, A, Lee, K, Movahed, M, Strootman, D, Chernick, R, Parrott, C, Flock, C, Marques, V, Syzmanski, E, Rama, P, Domingo, D, Wu, L, Bauer, B, Dionisopoulos, P, Aggarwal, A, Holcomb, R, Foster, R, Hancock, T, Hargrove, J, Fletcher, A, Stine, R, Bullivant, M, Adams, K, Lohman, J, Klepper, V, Kabour, A, Neidhardt, J, Phillips, W, Tardiff, S, Aji, J, Corut, S, Foster, G, Firek, C, St Goar, F, Sumner, R, Davis, T, Schneider, R, Schneider, W, Villa, A, Desai, V, Chhabra, A, Banks, K, Herzog, W, Burley, T, Quyyumi, A, Smiley, W, Manocha, P, Fishbein, G, Weller, C, Coffman, A, Kim, C, Kedia, A, Firth, B, Rizvi, M, Dahiya, R, Foster, B, Balcells, E, Metzger, Dc, Lester, J, Bissett, J, Fahdi, I, Sides, Ea, Azrin, M, Martin, C, Quick, A, Conaway, D, Garg, M, Schallert, G, Lancaster, L, Mckissick, S, Atieh, M, Garbarino, J, Eisenberg, D, Uusinarkaus, K, Wirtemburg, P, Ellis, J, Cristaldi, J, Berglund, R, Negus, B, Pappas, J, Rocha, R, Nguyen, T, Stone, J, Janosik, D, Labovitz, A, Elmore, N, Dave, R, Loffredo, K, Gabriel, G, Snyder, C, Ahmed, O, Stone, H, Kelley, M, Diffenback, M, Friedman, B, Zirkle, J, Severa, L, Sample, S, Dignen, K, Raisinghani, A, Ben-Yehuda, O, Ghannadian, B, Moscoso, R, Mankowski, J, Boliek, W, Rukavina, M, Davis, W, Ledbetter, S, Handel, F, Mastouri, R, Mahenthiran, J, Foltz, J, Malhotra, V, Jonas, J, Berk, M, Singh, V, Nelson, M, Elsner, G, Gall, J, Kondo, N, Frank, S, Chandraratna, P, Ranasinghe, S, Ebrahimi, R, Treadwell, M, Walters, B, Hughes, L, Kramer, J, Kumar, K, Mente, T, Lachterman, B, Schifferdecker, B, Munshi, K, Sease, D, Waldo, D, Chandler, G, Manns, D, Nahhas, A, Kamalesh, M, Williams, V, Reich, D, Desalca, M, Sharma, S, Liston, M, Gupta, K, Costa, M, Altschuller, A, Lemmertz, K, Shanes, J, Hansen, C, Therrien, M, Mendelson, R, Ramnarine, R, Myers, G, Donovan, C, Klein, M, Fine, D, Owens, S, Murray, C, Ketroser, R, Heifetz, S, Darnell, Z, Touchon, R, Taghizadeh, B, Bohle, D, Norwood, D, Forrest, T, Jackson, S, Shumate, K, Bayles, A, Masroor, M, North, Wk, Fishberg, R, Merveil-Ceneus, B, Butcher, R, Menapace, F, Kilbride, S, Ramabadran, Rs, Loukinen, K, Khalil, J, Ramabadran, R, Walsh, S, Gill, S, Cyncar, R, Mclachlan, J, Surakanti, V, Rusterholtz, L, Shoukfeh, F, Stephenson, L, Tsang, M, Nolan, V, Gilchrist, I, Jefferson, D, Feldman, T, Reyes, L, Santos, R, Little, W, Wesley, D, Gharib, W, Mendell, A, Esham, G, Kakavas, P, Whitcomb, C, Book, K, Bazzi, A, Alvarez, J, Cohen, Y, Ayres, T, Rhule, V, Labib, A, Schuler, P, Zughaib, M, Telck, K, Bikkina, M, Turnbull, K, Sharma, T, Orosz, S, Shah, R, Petrino, M, Hughes, M, Hershey, J, Hudock, D, Hui, P, Von Bakonyi, A, Arnold, A, Kappel, D, Pennock, G, Cloud, B, Tucker, K, Harp, L, Hoover, C, Eisenhauer, M, Roth, J, Young, C, Thai, H, Escalante, A, Bautista, J, Gazmuri, R, Nyland, J, Cubeddu, L, Defranco, A, Dias, D, Fielding, M, Reeves, R, Hermany, P, Meissner-Dengler, S, Evans, M, Flores, E, Tannenbaum, A, Mcgarr, K, Moran, J, Stout, E, Allred, S, Henderson, D, Crandall, L, Strote, J, Voyles, W, Robeson, D, Bedoya, R, Omar, B, Pettyjohn, F, Revere, C, Coy, K, Margolis, J, Sotolongo, C, Scheffel, M, Munir, A, Shirwany, A, Douglas, L, Girala, R, Humphreys, R, Agarwal, J, Bankowski, D, Watson, R, Bishop, B, Klementowicz, P, Blais, D, Cohen, B, Lobur, E, Dimenna, J, Dempsey, K, Izzo, M, Bondi, L, Carell, E, Eaton, C, Saltiel, F, Grewal, G, Connolly, T, Little, T, Wiegman, P, Gips, S, Held, J, Paraschos, A, Quesada, R, Goudreau, E, Sears, M, Istfan, P, Holt, S, Mcclung, J, Nguyen, N, Quintana, O, Gottlieb, D, Knutson, T, Barringhaus, K, Lester, F, Sullivan, P, Rodriguez-Ospina, L., IMPROVE-IT Investigators, Musliner, T., Tershakovec, A., Gurfinkel, E., Aylward, P., Tonkin, A., Maurer, G., Van de Werf, F., Nicolau, J.C., Theroux, P., Genest, J., Armstrong, P., Corbalan, R., Isaza, D., Spinar, J., Grande, P., Voitk, J., Kesaniemi, A., Bassand, J.P., Farnier, M., Darius, H., Keltai, M., Mathur, A., Mittal, S., Reddy, K., Lewis, B., De Ferrari, G.M., Ophuis, T.O., Jukema, J., White, H., Pedersen, T., Britto, F., Ruzyllo, W., Carrageta, M., Duris, T., Dalby, A., Seung, K.B., Lopez-Sendon, J., Dellborg, M., Mach, F., Guneri, S., Parkhomenko, A., Brady, A., Cannon, C., Blazing, M., Ballantyne, C., de Lemos, J., Kleiman, N., McGuire, D.K., Centeno, E., Casalins, M., Cartasegna, L., Beltrano, M.C., Guerrero, R., Fanuele, M., Berra, F., Egido, J., Colombo, H., Dellatorre, M., Terns, P., Blumberg, E., Reges, P., Azize, G., Ramos, H., Fernandez, R., Carlessi, C., Milesi, R., Schmuck, R., Duronto, E., Procopio, G., Carlevaro, O., Maffeo, H., Beloscar, J., Viso, M., Hominal, M., Castoldi, M., Bluguermann, J., Mauro, D., Macin, S., Cocco, N., Ruiz, N., Ricart, J., Lozada, A., Nani, S., Turri, D., Fernandez, H., Caruso, O., Zarandon, R., Bono, J., Arias, V., Allall, O., Marino, J., Cusimano, S., Schygiel, P., Buzetti, C., Penaloza, N., Berli, M., Worthley, S., Roach, A., Chew, D., Wright, T., Leitch, J., Hicks, E., Rankin, J., Venn-Edmonds, C., Lehman, R., Morrison, H., Shaw, J., Mak, V., Hii, C., Smith, K., Cross, D., Lilwall, L., Nelson, G., Loxton, A., Horowitz, J., Rose, J., Steinwender, C., Leisch, F., Kammler, J., Brussee, H., Zweiker, R., Niederl, E., Weihs, W., Giorgio, G., Lang, I., Drexel, H., Zanolin, D., Hoppe, U., Atzenhofer-Baumgartner, K., Pichler, M., Hainzer, D., Eber, B., Pichler, F., Foeger, B., Wechselberger, T., Mayr, H., Hofer, J., Stockenhuber, F., Warlits, B., Huber, K., Egger, F., Weidinger, F., Ziegler, B., Jirak, P., Metzler, B., Pachinger, O., Wanitschek, M., Auer, J., Grabscheit, G., Podczeck-Schweighofer, A., Priesnitz, T., Frank, H., El Allaf, D., Marechal, P., Roosen, J., Joly, E., Lefebvre, P., Arend, C., Sinnaeve, P., De Velder, L., Hellemans, S., Vanhauwaert, B., Van Dorpe, A., Heyse, A., Vantomme, C., Striekwold, H., Van Den Broeck, D., Lancellotti, P., Schoors, D., Lemoine, I., Taeymans, Y., De Wolf, L., Brike, C., Vercauteren, S., Tahon, S., Vervoort, G., Mestdagh, I., Pirenne, B., Cardinal, F., Lips, S., Dujardin, K., Debrouwer, K., Dhooghe, G., Holvoet, G., van de Borne, P., Renard, M., De Clippel, M., Lesseliers, H., Van Miert, N., Saraiva, J., Vicente, C., Rossi, P., Dos Santos, L.B., Duda, N., Tognon, A.P., Serrano, C., Gomes, F.L., Manenti, E.R., Silveira, D.S., Maia, L., Mouco, O.M., Paiva, M., Antonangelo, A., de Souza, J., Lino, E.A., Leães, P., Blacher, M.G., Kormann, A., Ultramari, F.T., Dutra, O., Mendelski, A.M., Morgado, S., Ardito, W., Greque, G., Ardito, R.V., Pimentel Filho, P., Zucchetti, C., Alves, A., Seabra, A.M., Mattos, M., Miranda, L.F., Silva, D., Uehara, R.M., Marin Neto, J., Schmidt, A., Braga, J., Rodrigues, A., Abrantes, J., Pinheiro, L., Bodanese, L., Magedanz, É.H., Piegas, L., Dos Santos, E.S., Wainstein, M., Ribeiro, J., Stein, R., Marino, R., Machado, V.M., Moraes Junior, J., Guimarães, S., da Costa, F.A., Ferraz, R.F., Albuquerque, D., Rocha, R.M., de Carvalho Moreira, R., Dohmann, H., Costantini, C., Tarastchuk, J.C., Coelho, O., Cirillo, W., Sousa, A., Almeira, A.S., Stefanini, E., Silva, F., Teixeira, M., da Cunha, C., Précoma, D., Facchi, T.L., Rupka, D., Thiessen, S., Warnica, J., Smith, B., Della Siega, A., Klinke, P., Nelson, S., Dion, D., Gilbert, N., Hui, W., Kvill, L., Sussex, B., Luther, A., Dupuis, R., Ouimet, F., Pandey, A., Clarus, S., Senaratne, M., Ferdinandis, H., Mukherjee, A., Bozek, B., Vizel, S., Markov, G., Zimmermann, R., Stephens, W., Tremblay, B., Wong, G., Uchida, N., Brossoit, R., Peck, C., Van Kieu, C., Forgione, M., Bata, I., Cossett, J., Kostuk, W., Arnold, M., Bone, C., Grondin, F., Bilodeau, N., Gosselin, G., David, M., Giannoccaro, J., Beresford, P., Polasek, P., Roberts, P., Doucet, M., Beaudry, M., Cheung, S., Cleveland, T., Bhargava, R., McCallum, A., Ma, P., Morrissette, J., Cleveland, D., Chadwyn, D., Nigro, F., Weeks, A., Cryderman, C., Leader, R., Houde, G., Rousseau, S., Pearce, M., Radyk, M., Lonn, E., Magi, A., Lefkowitz, C., Sandrin, F., Coffin, N., Lubelsky, B., Coldwell, J., Habot, J., McPherson, C., De Larochelliere, R., Roy, M., Haichin, R., Barber, C., Bhesania, T., Kitagawa, H., To, T., Donnelly, B., Tymchak, W., Harris, L., Kouz, S., Huynh, T., St Jacques, B., Lamy, A., Rizzo, A., Stein, J., Childs, C., Wong, B., Poirier, R., Gupta, M., Dela Cruz, C., Constance, C., Gauthier, M., Ervin, F., Ouellette, M., Kokis, A., Lemay, C., Kwok, K., Leung, C., Lee, D., Nesmith, J., Renton, J., Syan, G., Turek, M., Hogan, D., Griffin, P., Lipson, A., Winestock, J., Abramson, B., Fogel, A., Gagne, C., Bergeron, J., Clarke, A., Slipp, S., Darcel, I., Carling-Chambers, L., Kannampuzha, P., Pallie, S., Krekorian, S., Vertes, G., Roth, S., Lai, K., Heath, J., Perez, L., Arriagada, G., Castro, P., Villa, F., Rodríguez, M., Ramos, G., Baraona, F., Núñez, A., García, M., Jofre, C., Silva, P., Lamich, R., Yovaniniz, P., Escobar, E., Dussaubat, A., Segura, E., Ramirez, M., Lapostol, C., Palma, A., Encina, L., Zapata, M., Baeza, N., Varela, P., Pérez, L., Jaramillo, C., Ruiz, S., Sanchez, G., Perdomo, I., Manzur, F., Cohen, L.E., Velasquez, J., Arana, C., Alvarez, Y., Triana, M., Balaguera, J., de Salazar, D., Rendon, N., Botero, R., Ruiz, A., Saaibi, J., Medina, J., Jaramillo, M., Calderón, M.J., Delgado, J., Bohorquez, R., Medina, M.F., Herrera, M., Rosales, D., Mendoza, F., Martinez, S., Ternera, A., Castro, R., Baiz, A., Martinez, M., Orozco, A., Suarez, M., Fonseca, Y., Beltran, R., Cepeda, M., Jaramillo, N., Valenzuela, C., Gutierrez, M., Sanchez, A., Vitovec, J., Hlinomaz, O., Poloczek, M., Mayer, O., Veselka, J., Vejvoda, J., Soucek, M., Spac, J., Novobilsky, K., Srp, V., Francek, L., Branny, M., Sknouril, L., Motovska, Z., Rohac, F., Stankova, A., Fiala, T., Holub, M., Zeman, K., Pohludkova, L., Pospisilova, E., Tuma, P., Cihalik, C., Oral, I., Podpera, I., Stepanovova, R., Uricar, M., Solar, M., Pelouch, R., Porzer, M., Grussmannova, K., Stipal, R., Reichert, P., Hradec, J., Kral, J., Sejkova, B., Janek, B., Pitha, J., Linhart, A., Polacek, P., Koeber, L., Clemmensen, P., Hebin, C.H., Schmidt, E., Pedersen, M.S., Roseva-Nielsen, N., Kristensen, K., Bang-Hansen, T., Jensen, J., Laage-Petersen, J., Nielsen, H., Stokholm, E., Thayssen, P., Cappelen, H., Jensen, T., Winther-Friis, B., Klausen, I., Hedegaard, B., May, O., Andersen, M., Bottzauw, J., Lush, A., Markenvard, J., Vestager, K.M., Bronnum-Schou, J., Hempel, H., Petersen, J., Nielsen, A.J., Thomsen, K., Nielsen, T., Nygaard, A., Sykulski, R., Jensen, B.S., Ralfkiaer, N., Gottschalck, H., Rasmussen, S., Pedersen, L.R., Dodt, K., Skovsbøl, M., Andersen, O., Tuxen, C., Meier, A.W., Kristensen, T., Rasmussen, O., Lopez, J., Salazar, D., Sanchez, L., Rosero, F., Penaherrera, E., Duarte, Y.C., Marmol, R., Andrade, G., Guzman, E., Morillo, A., Aug, L., Loogna, I., Laanmets, P., Mustonen, J., Mäntylä, P., Kesäniemi, A., Ukkola, O., Kervinen, H., Juhela, S., Juvonen, J., Toppinen, A., Jarvenpaa, J., Syvanne, M., Svahn, T., Voutilainen, S., Huotari, A., Nikkila, M., Raiskinmäki, S., Kotila, M., Rajala, A., Laukkanen, J., Hiltunen, P., Melin, J., Nyman, K., Luukkonen, J., Kosonen, P., Huttunen, M., Seppänen, V., Airaksinen, J., Juonala, M., Lehto, S., Savolainen, K., Halkosaari, M., Sia, J., Palomaki, A., Luoma, J., Utriainen, S., Valpas, S., Tiensuu, T., Lilleberg, J., Kainulainen, R., Schiele, F., Bassand, J., Meneveau, N., Galinier, M., Jean, M., Martelet, M., Mouallem, J., Elbaz, M., Puel, J., Carrié, D., Coisne, D., Varroud-Vial, N., Jaboureck, O., Dujardin, J., Leroy, F., Mansourati, J., Funck, F., Jourdain, P., Guillard, N., Coviaux, F., Gay, A., Dourmap-Collas, C., Froger-Bompas, C., Paillard, F., Tricot, O., Maquin-Mavier, I., Dubois-Rande, J.L., Pongas, D., Paris, A.P., Delahaye, F., Ovize, M., Benyahya, L., Bonnet, J., Belle, L., Mangin, L., Lafitte, B., Zemour, G., Doux, N., Agraou, B., El Mansour, N., Traisnel, G., El Jarroudi, M., Ohlmann, P., Diadema, B., Escande, M., Legros, G., Demarcq, J.M., Haftel, Y., Alsagheer, S., Dambrine, P., Cottin, Y., Ghostine, S., Caussin, C., Gacem, A., Bouvier, J.M., Poulard, J., Davy, J., Furber, A., Prunier, F., Muenzel, T., Genth-Zotz, S., Appel, K., Kretzschmar, D., Ferrari, M., Terres, W., Uher, T., Schulze, H., Ochs, H., Morbach, S., Duengen, H., Gross, M., Oezcelik, C., Tahirovic, E., Heuer, H., Laschewski, B., Kadel, C., Rahn, G., Steiner, S., Kreuzer, J., Tsoy, I., Zeiher, A., Muegge, A., Hanefeld, C., Boehm, S., Boudriot, E., Hodenberg, E., Lippe, B., Hausdorf, C., Sydow, K., Baldus, S., Schlesner, C., Tiroch, K., Haltern, G., Guelker, H., Wilhelm, J., Dietz, S., Ebelt, H., Buerke, M., Rupprecht, H., Rittgen, J., Schaeufele, T., Meinhardt, G., Schieber, M., Honold, M., Sieprath, S., Nienaber, C., Hacker, J., Butter, C., Lapp, H., Hirn, S., Pauschinger, M., Zahn, R., Scheffler, U., Schaefer, A., Schieffer, B., Tebbe, U., Kriete, M., Mudra, H., Raeder, T., Braun, P., Zeymer, U., Kouraki, K., Reppel, M., Schunkert, H., Weil, J., Olbrich, H., Schwaiger, P., Mueller, O., Blessing, E., Buss, I., Bohlscheid, V., Kaddatz, J., Skowasch, D., Nickenig, G., Twelker, K., Osterhues, H., Varghese, T., Burghard, S., Kaeaeb, S., Klauss, V., Sohn, H.Y., Hauptmann, K., Schulze, M., Gall, K., Felix, S., Doerr, M., Mante, J., Gulba, D., Freick, M., Werner, G., Kleinertz, K., Hobbach, H.P., Halbach, M., Mueller-Ehmsen, J., Mueller, M.E., Mitrovic, V., Peil, A., Laufs, U., vom Dahl, J., Baumanns, S., Scholtz, W., Wiemer, M., Haude, M., Van de Loo, A., Pistorius, K., Schaefer, J., Schwinger, R., Goeing, O., Jung, W., Birkemeyer, R., Lee, W., Kong, S., Yu, C., Chui, K., Merkely, B., Szelényi, Z., Polgár, P., Svab, S., Herczeg, B., Bajcsi, É., Vértes, A., Davidovits, S., Nagy, A., Király, C., Lupkovics, G., Kenéz, A., Poór, F., Takács, J., Kirschner, R., Simonyi, G., Koncz, J., Édes, I., Gergely, S., Katona, A., Nagy, E., Kovács, Z., Gyetvai, I., Salamon, C., Kolman, É., Sitkei, É., Csapó, K., Molnar, K., Mező, I., Sereg, M., Reddy, P., Manjunath, C., Narayanappa, S., Kumar, S., Sinha, N., Kapoor, A., Christopher, J., Reddy, G., Rani, M., Oomman, A., Ramamurthee, K., Kumar, N., Pasha, S.S., Rao, C., Murty, G.S., Chopra, A., Kapila, D., Bali, H., Chattree, K., Hasan, O., Suryaprakash, G., Rao, D., Babu, R., Bhargavi, M., Naik, S., Khan, S., Chopra, V., Sapra, R., Kaul, U., Ghose, T., Menon, R., Battikadi, S., Mullasari, A., Subban, V.K., Dani, S., Iby, M., Chandra, P., Sethi, S., Bhargava, M., Arora, P., Tyagi, G., Padmanabhan, T., Malhotra, S., Talwar, K., Shafiq, N., Kasliwal, R., Bansal, M., Eldar, M., Berger, M., Shechter, M., Atar, S., Roguin, N., Kilimnik, M., Hayek, T., Hamoud, S., Katz, A., Plaev, T., Shotan, A., Vazan, A., Weiss, A., Leibowitz, D., Zimlichman, R., Ben-Aharon, J., Hammerman, H., Dragu, R., Rozenman, Y., Witzling, V., Tzivoni, D., Moriel, M., Halkin, A., Sheps, D., Bogomolny, N., Mosseri, M., Khudyak, Y., Halabi, S., Uziel-Iunger, K., Yuval, R., Shimoni, S., Caspi, A., Botwin, S., Gavish, D., Sandler, A., Pollak, A., Kreisberg, B., Hussein, O., Jabal, K., Henkin, Y., Grosbard, A., Rosenschein, U., Rivlin, E., Zeltser, D., Platner, N., Porter, A., Harel, N., Lishner, M., Elis, A., Karny, M., Fuchs, S., Stein, G., Grossman, E., Gealel, Z., Schlaeffer, F., Liberty, I., Golik, A., Tzuman, O., De Ferrari, G., Pavesi, C., Poggio, L., Damiano, S., Pazzano, A.S., Mennuni, M., Paloscia, L., Mascellanti, M., Piovaccari, G., Grosseto, D., Mascia, F., Vetrano, A., Zingarelli, A., Mazzantini, S., Visconti, L., Terzi, G., Senni, M., Gavazzi, A., Scuri, P., Carmelo, M., De Caterina, R., Conti, M., Novo, S., Graceffa, A., Arvigo, L., Lunetta, M., Filardi, P., Chiariello, M., Scala, O., Pirozzi, E., Musella, F., Moretti, L., Testa, M., Vicentini, A., De Feo, S., Biasucci, L., Cardillo, M.T., Puccioni, E., Galli, M., Menegato, A., Margheri, M., Maresta, A., Gatti, C., Guarini, P., Damiano, M., Golino, P., Porcu, M., Fele, N., Gensini, G., Lombardi, A., Ciuti, G., Bernardi, D., Mariani, P., Paolini, E., Marenzi, G., Moltrasio, M., Terrosu, P., Chessa, P., Guglielmino, G., Miccoli, F., Oldoino, E., Ragni, M., Poli, M., Basso, V., Rapezzi, C., Branzi, A., Gallelli, I., Perna, G., Guazzarotti, F., Marra, S., Usmiani, T., Olivari, Z., Calzolari, D., Santoro, G., Minneci, C., Achilli, A., Nassiacos, D., Sommariva, L., Romeo, F., Fedele, F., Foschi, M.L., Bruno, N., Centurion, C., Patrizi, G., De Maria, E., Gonnelli, S., Vichi, V., Cassadonte, F., Rotella, G., Capucci, A., Villani, G., Gaspardone, A., Ferrante, R., Scollo, V., Pancaldi, L., Saccà, S., Gabrielli, D., Ciliberti, D., Savini, E., Binaghi, G., Di Biase, M., Ieva, R., Fattore, L., Cicia, G., Cavallini, C., Tamburino, C., Sacco, A., Mafrici, A., Di Pasquale, G., Pavesi, P.C., Scioli, R., Lioy, E., Occhiuzzi, E., Matino, M.G., Russo, V., Moscogiuri, M.G., Cuccia, C., Forgione, C., Volpe, M., Palano, F., Branca, G., Rossi, R., Modena, M., Olaru, I.A., Zanini, R., Cianflone, D., Cristell, N., Pantaleoni, M., Guiducci, U., Menozzi, C., Gaddi, O., Fasulo, A., Indolfi, C., Emanuele, V., Guerra, F., Iliceto, S., Marotta, C., Morocutti, G., Presbitero, P., Rossi, M., Bonatti, S., Grieco, A., Chiodi, L., Betti, I., Zuppiroli, A., Fanelli, R., Stanco, G., Azzolini, P., Ruggieri, C., Bocconcelli, P., Airoldi, F., Tavano, D., Brunelli, C., Caso, P., Scalzone, A., Ghigliotti, G., Facciorusso, A., Sim, K., Kiam, O., Chee, K., Bin Ismail, O., Zambahari, R., Ophuis, T., van Nes, E., Werter, C.J., Ophuis, A.J., Troquay, R.P., Hamer, B.J., Lenderink, T., Feld, R.J., van Hessen, M.W., Viergever, E.P., van der Sluis, A., Lok, D.J., Badings, E.A., Nierop, P.R., Danse, I.Y., Hermans, W.R., Holwerda, N.J., Thijssen, H.J., Theunissen, L.J., van der Zwaan, C., Van Den Berg, B.J., Hendriks, I.H., Ronner, E., Withagen, A.J., Dijkshoorn-Giesen, A.H., Ezechiels, J.P., Kuijper, A.F., Den Hartog, F.R., Van Kalmthout, P.M., Buijs, E.M., van der Zeijst, M., Zwart, P.A., Zuidgeest, J.A., van Eck, M., Daniels, M.C., van der Ven-Elzebroek, N., Van 't Hof, A., van Boven, A.J., van der Weerdt, A., Dunselman, P.H., Alings, M.A., van Es, R.F., The, S.H., Gurlek, C., Liem, A.H., van Lennep, H.W., Van Vlies, B., Kalkman, C., Swart, H.P., van der Bij, P., Taverne, R., Ciampricotti, R., van Dam, C., Spierenburg, H., van Ruijven, I., van Kempen, L.H., Willems, F.F., Dirkali, A., Stoel, I., Plomp, J., Veldmeijer, S., Tjeerdsma, G., Nijmeijer, R., Van Hal, J.M., Bartels, G.L., Posma, J.L., Linssen, G.C., Fauser, C.G., Waalewijn, R.A., Groenemeijer, B.E., Pos, L., Fast, J.H., Droste, H.T., Westenburg, J., Veenstra, W., Koolen, J., van Loo, L.W., Smits, W., Milhous, J.G., van Rossum, P., Stuij, S., Scott, R., Richards, A.M., Morrison, Z., Devlin, G., Fisher, R., Stewart, R., Benetar, J., Voss, J., Wong, S., Scott, D., Luke, R., Tang, E., Davidson, L., Hamer, A., Wilson, S., Price, R., Hart, H., Turner, A., Jortveit, J., Calic, S., Gundersen, T., Brunvand, H., Fosse, L., Nygaard, O., Gjellefall, B., Gravdal, S.A., Ringstad, R., Atar, D., Clausen, H., Hysing, J., Arvesen, K., Topper, M., Flagstad, E., Graven, T., Haug, H.H., Dalin, L., Al-Ani, R., Otterstad, J., Ausen, K., Aaser, E., Olufsen, M., Halvorsen, S., Gullestad, L., Stueflotten, W., Waage, K., Stødle, R.M., Hall, C., Aase, O., Nordeng, J., Soyland, E., Fageraas, E.R., Lied, A., Aske, R., Raouf, N., Johansson, J., Herrscher, T., Skogrand, E., Bjornstad, H., Aagnes, I., Arntsen, B.I., Vegsundvaag, J., Skjold, M.E., Velle, H., Aambakk, M.B., Skjetne, O., Byfuglien, A., Rodriguez, J., Galvez, D., Medina, F., Hernandez, H.A., Chavez, V., Morales, R., Huapalla, E., Velasquez, D., Torres, F., Aguirre, O., Yanez, L., Andrade, M., Campos, C., Arce, R., Mogrovejo, W., Osores, F., Bustamante, G., Rodriguez, M., Berrospi, P., Garcia, C., Talledo, M., Navarro, P., Horna, M., Herrera, V., Kadziela, J., Rybicka-Musialik, A., Trusz-Gluza, M., Berger-Kucza, A., Musial, W., Tycinska, A., Gil, R., Gziut, A., Gorny, J., Tyllo, M., Reszka, Z., Mickiewicz-Pawlowska, M., Wrzosek, B., Kosior, J., Staneta, P., Korzeniak, R., Kalarus, Z., Markowicz, E., Miekus, P., Konarzewski, M., Kleinrok, A., Puzniak, M., Grajek, S., Janus, M., Krzyzanowski, M., Hoffmann, A., Muzalewski, P., Polonski, L., Kazik, A., Nowalany-Kozielska, E., Wojciechowska, C., Ponikowski, P., Nawrocka, S., Filipiak, K., Serafin, A., Dubiel, J., Mielecki, W., Ogorek, M., Kopcik, D., Jaworska, K., Skonieczny, G., Kawecka-Jaszcz, K., Bryniarski, L., Tracz, W., Lesniak-Sobelga, A., Jankielewicz, J., Zaluska, R., Trojnar, R., Kawalek, P., Gaciong, Z., Pulkowski, G., Anaszewicz, M., Samul, W., Adamus, J., Cholewa, M., Kubik, L., Szczechowicz, R., Rekosz, J., Kwiatkowska, D., Gajek, J., Mazurek, W., Kominek, M., Siminiak, T., Guzniczak, E., Monteiro, P., Providencia, L., Monteiro, S., Pinho, T., Gavina, C., Sousa, C., Loureiro, J., Ferreira, A.R., Cardoso, A., Araujo, J., Rebolo, I., Catarino, C., Santos, J., Nunes, L.P., Mimoso, J., Marques, N., Leitao, M., Pais, J., Fernandes, A., Diogo, A., Nóbrega, J., Moreira, J.I., Mateus, P., Oliveira, J., Selas, M., Ribeiro, V., Albuquerque, A., Reis, R., Ramos, A., Salazar, F., Nair, D., Ng, C.K., Yeo, D., Wong, A., Funiak, S., Belicova, M., Striezova, I., Krajci, P., Sojka, G., Herman, O., Zemberova, A., Pella, D., Fedacko, J., Banikova, A., Micko, K., Macek, V., Moscovic, M., Vahala, P., Vykoukalova, T., Dzupina, A., Marusakova, M., Stevlik, J., Akubzanova, E., Hatalova, K., Burgess, L., Coetzee, C., Mabin, T., Roos, J., Mohamed, Z., Pillay, T., Corbett, C., Bodenstein, W., Tayob, F., Ebrahim, I., Bolsman, C., Horak, A., Lloyd, E., Pretorius, M., Commerford, P., De Andrade, M., Roux, J., Murray, A., Soma, P., Delport, E., Cassel, G., Van Zyl, L., Cronje, T., Sarvan, M., Moodley, R., Guerra, M., Swanepoel, N., Bayat, J., Klug, E., Hellig, S., Yoon, J., Kim, J., Chung, W., Choi, Y., Cho, M., Lee, S., Kwon, H., Hong, B., Seung, K., Chang, K., Rha, S., Jeong, M.H., Hong, Y., Lee, C., Seong, I., Jeong, J., Tahk, S., Yoon, M., Chae, S.C., Kim, H., Lopez, V., Roldan, J.M., Mancisidor, P., Froufe, J., López, A., Franco, S., Molina, A., Soriano, F., Cobos, M., Mejía, H.D., Sanz, R., Vazquez, A., Garri, F., Esteban, I., Marco, P., Artaecheverria, J., Cequier, A., Esplugas, E., Gonzalez, J., de Sa, E., Armada, E., Worner, F., Hernández, I., Roncales, F., Gomollon, J., del Rio, A., Alameda, J., Basilio, E., Rafols, M., Ferres, R., Molla, C., Pascual, J., Cortada, J., García, C., Iglesias, G., Villa, E., Aros, F., Goya, I., Bueno, M., Pereira, R.V., Clavero, X., Pasaron, C.D., Jorda, R., Pereira, R., Perez, O., de Teresa, E., Navarro, M., de la Guia, F., Lozano, T., Antorrena, I., Aranda, M., Alonso, L., Mirelis, J., Alcasena, S., Paniagua, V.A., Juanatey, J., Gregorian, L., Munoz, J., Escorihuela, A., Sanz, A., Flores, A., Garcia, P.A., Alfonso, F., Marin, E., Lozano, A., Bethencourt, A., Grau, A., Rubio, A., Sala, J., Royuela, N., San Jose, J., Bugos, V., de Valdecilla, H., Martin, J., Jimenez, R., Felgueres, M., Escalera, P., Ruiz, R., Bescos, L., Sanchez, I., Chavarri, M., Casares, G., Johanson, P., Hultsberg-Olsson, G., Witt, N., Samad, B., Damm, T., Risenfors, M., Ortgren, L., Henareh, L., Jernberg, T., Berglund, M., Karlsson, J., Koch, A., Lycksell, M., Lundgren, C., Herlitz, J., Sjölin, M., Erlinge, D., Matson, E., Cizinsky, S., Carlsson, F., Ryttberg, B., Johansson, K., Tygesen, H., Bergsten, J., Naslund, U., Sundholm, C., Timberg, I., Wikström, P., Hårdhammar, P., Lisbeth, A., Lund, L., Hage, C., Rosenqvist, U., Grändås, M., Larsson, L., Hammerman, A., Andersson, G., Johansson, S., Bennermo, M., Tjerneld, H., Forsgren, M., Eriksson, K., Eriksson, M., Bengtsson, P.O., Yu, W., Ceder-Brolin, K., Stafberg, C., Andersson, E., Roussine, V., Ångman, K., Melin, B., Thorsen, S., Lundell, L., Buijs, F., Östberg, S., Sigaud, P., Moccetti, T., Bondio, M., Kuehlkamp, V., Pieper, M., Gallino, A., Zender, H., Genné, D., Gauthey, J., Wilhelm, M., Saner, H., Trachsel, L., Roethlisberger, C., Schlaepfer, H., Kujawski, T., Pagnamenta, A., Meyer-Monard, S., Krapf, R., Biedermann, B., Schneider, H., Rickli, H., Ramsay, D., Linka, A., Ballmer, P., Oswald, M., Girod, G., Charng, M., Shu-Ling, H., Ping-Han, L., Wu, C., Liu, S., Lin, M., Chian-Yi, W., Yeh, H., Mei-Juan, C., Hsieh, I., Wang, Y., Ural, E., Sahin, T., Yildiz, Z., Kayikcioglu, M., Kultursay, H., Yigit, Z., Calpar, I., Ata, N., Goktekin, O., Senol, U., Yalcin, R., Timurkaynak, T., Kaya, U., Yildirir, A., Karacaglar, E., Faynyk, A., Sorokivskyy, M., Koval, O., Kaplan, P., Kraiz, I., Popova, K., Kyyak, Y., Barnett, O., Karpenko, O., Todoriuk, L., Tseluyko, V., Kopytsya, M., Petyunina, O., Kovalskyy, I., Zhukova, Y., Katerenchuk, I., M'yakinkova, L., Lutay, Y., Syvolap, V., Kyselov, S., Vakaliuk, I., Nesterak, R., Nikonov, V., Feskov, O., Goloborodko, B., Golovtsev, Y., Berezniakov, I., Lebedynska, M., Rudenko, L., Tutov, I., Ahsan, A., Burton, J., Levy, T., Lakeman, N., Spratt, J., Langford, E., Sutcliffe, S., Khwanda, A., Davis, G., Rodrigues, E., Dickinson, D., Been, M., Trouton, T., Riddell, J., Moriarty, A., McEneaney, D., Squire, I., Narayan, H., Goode, G., Helliwell, L., Boos, C., Greaves, K., Knops, K., Pegge, N., Signy, M., Wong, Y., Moore, S., Fluck, D., Atkinson, C., Adgey, A., McKeag, N., Bishop, A., Glover, J., Barbir, M., Breen, J., Robson, H., Townend, J., Dwenger, E., Ekpo, E., Shakespeare, C., Barr, C., McClements, B., McAllister, A., De Belder, M., Cooke, J., Williams, S., Daniel, D., Pye, M., Griffith, K., Wright, L., Trevelyan, J., Doughty, A., Hughes, E., Phillips, C., Penny, W., Groves, P., Kardos, A., Purvis, J., McNeill, A., Jones, A., Brown, J., Saeed, B., Sprigings, D., Herity, N., Brown, C., Unks, M., Cauthren, T., Bertolet, B., Jones, M., Decker, S., Chambers, J., Stahlberg, J., Varma, S., Gencheff, N., Price, A., McElroy, D., Chu, A., Crutchfield, B., Eaton, G., Looney, A., Qureshi, M., Wilks, J., Drenning, D., Overman, A., Andreou, C., Russo, P., Stuckey, T., Pruitt, H., D'Urso, M., DeRaad, R., Rogers, W., Thorington, S., Pasquini, J., Iwaoka, R., Tannenbaum, M., Prouty, D., Wiseman, A., Sharow, A., Graham, B., Ali, M.I., Dale, H., Tarsi, D., Picone, M., Juarez, S., Hamroff, G., Hollenweger, L., Scirica, B., Sabatine, M., Marti, J., Perlman, R., Pavlides, A., Joffe, I., Albirini, A., Campbell, T., Puri, S., Lopez, C., Pearce, D., Shah, D., McPherson, J., Donegan, R., Murdock, D., Block, D., Malik, A., Musina, R., Dauber, I., Varner, C., Bach, R., Palazzolo, M., Bhalla, H., Thompson, M., Pollock, S., Johnson, S., Lipson, L., Brunk, S., Karas, S., Vicari, R., Kuvin, J., Mooney, P., Aycock, G., Lane, B., Sharma, M., Gibson, T., Chang, G., DiVito, P., Mehta, R., Watkins, K., Chiu, A., Gunderson, J., Tedder, B., Williams, P., Hage-Korban, E., Childs, A., Banerjee, S., Kazi, F., Bennett, J., Barnes, D., Wohns, D., Noorman, C., Aggarwal, K., Lau-Sickman, A., Paulowski, J., Amos, M., Rider, J., Fenton, S., Schantz, M., Hakas, J., Mcsorley, J., Felten, W., Bitzer, V., Russell, J., Loyo, J., Adjei, A., Mehta, K., Uretsky, B., Hale, M., Shaikh, S., Miller, M., Hollenbaugh, D., Crawford, K., Fortuin, D., Galindo, A., Del Core, M., Butkus, E., Collins, J., Prior, J., Hahn, R., Greene-Nashold, J., Alexander, J., Genova, E., MacDonell, A., Broadwater, S., Kereiakes, D., White, D., Lopez, M., Schenks, R., Lui, H., Gibbons, P., Davis, B., Thornton, K., Daley, P., Budzon, S., McCullum, K., Delio-Cox, B., Nadar, V., Keim, S., McLaurin, B., Davis, C., Betzu, R., Al-Jumaily, J., Bolli, R., Alshaher, M., Leesar, M., Collins, T., Akkad, H., Bilazarian, S., Marsters, M., Kennett, J., Melegrito, K., Mostel, E., Harris, R., Chang, M., Hatfield, G., Makam, S., Garvey, M., Levite, H., White, J., Abdel-Latief, A., Pelletier, L., Carr, K., Mckenna, K., De Lemos, J., Soto, G., Kozina, J., Harris, D., Vlastaris, A., Bittel, B., Riba, A., Gugudis, J., Singh, N., Qureshi, I., Doty, W., Lehmann, J., Lieber, I., Martin, S., Nicu, M., Bhalodkar, N., Ravi, P., Canto, J., Bass, M., Campbell, C., Steinhubl, S., Moles, K., Harjai, K., Stapleton, D.D., Hoey, K., Erwin, J., Fikes, W., Stein, B., Sabatino, K., Teklinski, A., Colfer, H., Ward, P., Langevin, E., Faucett, S., Mamdani, S., DeSimone, L., Tuohy, E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
- Subjects
Male ,Simvastatin ,acute coronary syndrome ,aged ,anticholesteremic agents ,azetidines ,cardiovascular diseases ,cholesterol, ldl ,double-blind method ,drug therapy, combination ,ezetimibe ,female ,humans ,hydroxymethylglutaryl-coa reductase inhibitors ,kaplan-meier estimate ,male ,middle aged ,simvastatin ,triglycerides ,medicine (all ,[SDV]Life Sciences [q-bio] ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Bococizumab ,Triglyceride ,chemistry.chemical_compound ,0302 clinical medicine ,Azetidine ,Cardiovascular Disease ,Anticholesteremic Agent ,Acute Coronary Syndrome ,Aged ,Anticholesteremic Agents ,Azetidines ,Cardiovascular Diseases ,Cholesterol, LDL ,Double-Blind Method ,Drug Therapy, Combination ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Middle Aged ,Triglycerides ,030212 general & internal medicine ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Hazard ratio ,General Medicine ,Acute Coronary Syndrome, Aged ,Anticholesteremic Agents, Azetidines, Cardiovascular Diseases ,Ezetimibe, Female, Humans ,Male, Middle Aged ,3. Good health ,Multicenter Study ,Editorial ,Cholesterol ,Randomized Controlled Trial ,Combination ,Ezetimibe ,lipids (amino acids, peptides, and proteins) ,Human ,medicine.drug ,medicine.medical_specialty ,Acute Coronary Syndroms ,Urology ,Acute Coronary Syndrome/drug therapy ,Anticholesteremic Agents/adverse effects ,Anticholesteremic Agents/therapeutic use ,Azetidines/adverse effects ,Azetidines/therapeutic use ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/mortality ,Cardiovascular Diseases/prevention & control ,Cholesterol, LDL/blood ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ,Simvastatin/therapeutic use ,Triglycerides/blood ,NO ,LDL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Drug Therapy ,Internal medicine ,Journal Article ,medicine ,Comparative Study ,Alirocumab ,business.industry ,PCSK9 ,ta3121 ,Lomitapide ,DOENÇAS CARDIOVASCULARES ,Endocrinology ,chemistry ,Statin Therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
- Published
- 2015
4. Transport in Tornado Plasma
- Author
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Vormin, A., Sadamoto, Y., Uchida, N, and Uehara, K.
- Abstract
平成17年度スペース・プラズマ研究会 (2006年3月16日-17日. 宇宙航空研究開発機構宇宙科学研究本部(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県, Space Plasma Conference FY2005 (March 16-17, 2006. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000115012
- Published
- 2006
5. Improved reliability of repetitive RF interstitial heating in combination with brachytherapy: the effective use of water
- Author
-
Hirokazu Kato, Toshifumi Kasai, Uchida N, Sugihara M, and Sugimura K
- Subjects
Permittivity ,Cancer Research ,Absorption (acoustics) ,Materials science ,Physiology ,Radioactive source ,medicine.medical_treatment ,Brachytherapy ,Flow (psychology) ,Reliability (semiconductor) ,Neoplasms ,Physiology (medical) ,medicine ,Humans ,Phantoms, Imaging ,business.industry ,Reproducibility of Results ,Water ,Hyperthermia, Induced ,Radiofrequency Therapy ,Combined Modality Therapy ,Electrode ,Electric current ,Nuclear medicine ,business ,Biomedical engineering - Abstract
Interstitial heating and brachytherapy are often combined in the treatment of cancer. In such instances, a needle-type internal electrode is inserted into the RALS (remotely controlled afterloading system) catheter instead of a radioactive source. A problem with this approach, however, is that the temperature distribution pattern generated by the inserted electrode varies at any given target region in each heating treatment, which makes it difficult to accurately replicate the heating treatment protocol. This variation is suspected to be caused by non-uniformity in the small gap between the internal electrode and the inner surface of the surrounding catheter, causing electric currents to flow between the electrode and the heating material, which differs from procedure to procedure. To solve this problem, the gap was filled with water of high permittivity, and the temperature distribution was investigated using phantoms. With this method, a stable and reproducible temperature rise distribution was obtained in the phantom experiment.
- Published
- 2001
6. Compliance effects on small diameter polyurethane graft patency
- Author
-
Uchida N, Yukihiko Nosé, Shun Murabayshi, Ji-Feng Chen, Helen Kambic, Shan-hui Hsu, Hideto Emoto, and Hiroaki Harasaki
- Subjects
medicine.medical_specialty ,Mean arterial pressure ,Materials science ,Biomedical Engineering ,Hemodynamics ,Capsule ,Anastomosis ,Surgery ,Biomaterials ,Compliance (physiology) ,medicine.anatomical_structure ,Blood pressure ,Suture (anatomy) ,medicine ,Artery - Abstract
Microporous compliance matched and noncompliant grafts were compared in a dog carotid artery interposition model. We fabricated 4 mm diameter sponge type polyurethane (Biomer) tubes 5 cm in length with a 0.5 mm wall thickness. The luminal surface was covered with a 50 μm coating of cross-linked gelatin. Compliance was measured in vitro and in vivo by volume and vessel diameter changes. Over a mean arterial pressure range of 55–155 mm Hg, the diameter changes of grafts and stump arteries were measured in situ using an ultrasonic Hokanson device. Compliance matched grafts were found to have the same in vitro compliance values as the natural canine carotid at a mean arterial pressure of 100 mm Hg. Compliance matched and noncompliant grafts had values of 10.3 ± 1.3 and 0.9 ± 0.1 × 10−2 mm Hg, respectively. End to end arterial anastomoses were constructed between the graft and the host arteries. The use of synthetic grafts with matched compliance to the adjacent natural vessels has been advocated as the ideal solution to circumvent the problems of graft failure. These studies indicate that compliance values for compliance matched grafts decreased immediately after implantation (from 10.3 to 6.5 × 10−2 %/mm Hg) and within 6 weeks decreased to 3.6 × 10−2 %/mm Hg. The compliance values for noncompliant grafts remained constant throughout the test period. At autopsy all grafts showed a tightly adhered tissue capsule. The thickness of the anastomotic hyperplasia at the distal sites of compliance matched grafts was significantly different (P < .05) than that of the adjacent artery. The patency for compliant and noncompliant grafts was 64% and 50%, respectively. Evidence for polyurethane graft degradation was obtained by Fourier transform infrared spectroscopy and gel permeation chromatography analysis of patent explants. Compliance mismatch alone does not contribute to graft failure, however, material degradation, suture technique and/or capsule formation can play a contributory role although these were not tested directly. © 1993 John Wiley & Sons, Inc.
- Published
- 1993
7. Econophysics of precious stones
- Author
-
Watanabe, A., Uchida, N., and Kikuchi, N.
- Subjects
FOS: Economics and business ,Physics - Physics and Society ,FOS: Physical sciences ,Physics and Society (physics.soc-ph) ,General Finance (q-fin.GN) ,Quantitative Finance - General Finance - Abstract
The importance of the power law has been well realized in econophysics over the last decade. For instance, the distribution of the rate of stock price variation and of personal assets show the power law. While these results reveal the striking scale invariance of financial markets, the behaviour of price in real economy is less known in spite of its extreme importance. As an example of markets in real economy, here we take up the price of precious stones which increases with size while the amount of their production rapidly decreases with size. We show for the first time that the price of natural precious stones (quartz crystal ball, gemstones such as diamond, emerald, and sapphire) as a function of weight obeys the power law. This indicates that the price is determined by the same evaluation measure for different sizes. Our results demonstrate that not only the distribution of an economical observable but also the price itself obeys the power law. We anticipate our findings to be a starting point for the quantitative study of scale invariance in real economy. While the Black--Sholes model provided the framework for optimal pricing in financial markets, our method of analysis prvides a new framework that characterizes the market in real economy., 9 pages, 4 figures, PDF only
- Published
- 2006
8. Novel function of the eukaryotic polypeptide-chain releasing factor 3 (eRF3/GSPT) in the mRNA degradation pathway
- Author
-
Shinichi Hoshino, Hosoda, N., Araki, Y., Kobayashi, T., Uchida, N., Funakoshi, Y., and Katada, T.
- Subjects
Models, Molecular ,Cell Cycle ,Animals ,Humans ,RNA-Binding Proteins ,RNA, Messenger ,Saccharomyces cerevisiae ,Peptide Chain Termination, Translational ,Models, Biological ,Poly(A)-Binding Proteins ,Peptide Termination Factors ,Signal Transduction - Abstract
The mammalian GTP-binding protein GSPT, whose carboxy-terminal sequence is homologous to the eukaryotic elongation factor EF1alpha, binds to the polypeptide chain releasing factor eRF1 to function as eRF3 in translation termination. However, the amino-terminal domain of GSPT, which contains a prion-like sequence, is not required for the binding. Instead, the amino-terminal domain is capable of binding to the carboxy-terminal domain of polyadenylate-binding protein (PABP), whose amino terminus is associating with the poly(A) tail of mRNAs, presumably for their stabilization. Interestingly, multimerization of PABP with poly(A), which is ascribed to the action of its carboxy-terminal domain, was completely inhibited by the interaction with the amino-terminal domain of GSPT. This may facilitate shortening of the poly(A) tail of mRNAs by an RNase. Thus, GSPT/eRF3 appears to function not only as a stimulator of eRF1 in the translation termination but also as an initiator of the mRNA degradation machinery. Further physiological and cell biological approaches will be necessary to show whether our current in vitro findings on GSPT/eRF3 indeed reflect its bifunctional properties in living cells.
- Published
- 2000
9. Electrodeposition of Nano-crystalline Nickel-Molybdenum Alloys
- Author
-
Washio, R., Mizumoto, M., Ohgai, Takeshi, Kagawa, A., Takao, K., Uchida, N., Tanaka, Y., and Sumita, S.
- Subjects
nickel ,molybdenum ,magnetic property ,electrodeposition ,nano-crystal - Abstract
application/pdf, Nano-crystalline nickel-molybdenum alloys were electrochemically synthesized from aqueous solution. With increasing molybdenum content in the alloy up to 23.6%, the crystal grain size decreased down to several nanometers scale. The magnetic coercive force decreased to several oersteds with increasing the molybdenum content. Soft magnetic property of the alloy was improved compared with that of pure nickel., text, Nagasaki Symposium on Nano-Dynamics 2008 (NSND2008) 平成20年1月29日(火)於長崎大学 Poster Presentation, Nagasaki Symposium on Nano-Dynamics 2008 (NSND2008), pp.51-52
- Published
- 2008
10. From stem cells to lymphocytes:biology and transplantation
- Author
-
Aguila, H L, Akashi, K, Domen, J, Gandy, K L, Lagasse, E, Mebius, R E, Morrison, S J, Shizuru, J, Strober, S, Uchida, N, Wright, D E, and Weissman, I L
- Abstract
We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.
- Published
- 1997
11. [Peripheral blood stem cell transplantation for acute leukemia]
- Author
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Mizuno, S., Toyoshima, M., Niho, Y., Gondo, H., Okamura, T., Otsuka, T., Asano, Y., Makino, S., Taniguchi, S., Akashi, K., Murakawa, M., Takamatsu, Y., Fukuda, T., Ono, H., Iwasaki, H., Kuroiwa, M., Kanechi, Y., Takenaka, K., Tanimoto, K., Shigematsu, H., Yokoyama, T., Osaki, K., Tomofusa Fukuyama, Murakami, T., and Uchida, N.
- Subjects
Adult ,Male ,Leukemia, Myeloid, Acute ,Adolescent ,Hematopoietic Stem Cell Transplantation ,Humans ,Antineoplastic Agents ,Female ,Cell Separation ,Precursor Cell Lymphoblastic Leukemia-Lymphoma - Published
- 1996
12. Serum antioxidant status in streptozotocin-induced diabetic rat
- Author
-
Kazushige Dobashi, Shinpei Nakazawa, Asayama K, Takaya Nakane, Uchida N, and Hidemasa Hayashibe
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Antioxidant ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Iron ,Clinical Biochemistry ,medicine.disease_cause ,Biochemistry ,Antioxidants ,Diabetes Mellitus, Experimental ,Lipid peroxidation ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Vitamin E ,Sulfhydryl Compounds ,Serum Albumin ,biology ,business.industry ,Biochemistry (medical) ,Albumin ,Brain ,Ceruloplasmin ,Hexosamines ,General Medicine ,Streptozotocin ,medicine.disease ,Peroxides ,Rats ,Uric Acid ,Oxidative Stress ,chemistry ,biology.protein ,Fructosamine ,Uric acid ,Lipid Peroxidation ,business ,Oxidative stress ,medicine.drug - Abstract
To determine whether decrease in serum antioxidants contributes to the increased oxidative stress, we measured the antioxidant activity (AOA), total peroxyl radical-trapping antioxidant parameter (TRAP), and their component individual antioxidants in the serum of diabetic rats. AOA was assayed as the ability of serum to inhibit lipid autoxidation in brain homogenates. TRAP was assayed as the ability to delay lipid peroxidation induced by an azo initiator. Antioxidants measured were ceruloplasmin, unsaturated iron binding capacity (UIBC) and albumin as components of AOA; and uric acid, protein sulfhydryl and alpha-tocopherol as components of TRAP. AOA was decreased markedly in the diabetics due to the decrease in ceruloplasmin, UIBC and albumin. On the other hand, the directly measured TRAP in the diabetics was unaltered. Uric acid and alpha-tocopherol were increased in the diabetics. However, decrease in unidentified scavengers offset the increase brought about by those antioxidants These results suggest that the decreased metal binding capacity contributes to the increased oxidative stress in the diabetic rats.
- Published
- 1994
13. Surface Area Effects on Efficiency and Biocompatibility in Experimental Membrane Plasmapheresis
- Author
-
Toshiaki Suzuki, Paul S. Malchesky, Yukihiko Nosé, Uchida N, and Omokawa S
- Subjects
Extracorporeal Circulation ,Biocompatibility ,medicine.medical_treatment ,Biomedical Engineering ,Medicine (miscellaneous) ,Hemodynamics ,Biocompatible Materials ,Bioengineering ,Polyvinyl alcohol ,Biomaterials ,chemistry.chemical_compound ,Dogs ,medicine ,Animals ,Platelet ,Blood Cells ,Membranes, Artificial ,Plasmapheresis ,General Medicine ,Blood Cell Count ,Complement system ,Membrane ,medicine.anatomical_structure ,chemistry ,Immunology ,Vascular resistance ,sense organs ,Biomedical engineering - Abstract
The effect of different surface areas on cellular, humoral, and hemodynamic changes and on plasma separation performance were investigated. Membrane plasmapheresis, consisting of plasma separation and on-line reinfusion, was carried out on dogs for 3 h with 0.6 and 0.3-m2 polyethylene (PE) and polyvinyl alcohol (PVA) modules. The plasma separation and sieving performance was comparable in both the 0.6 and 0.3-m2 modules. The initial white blood count (WBC) reductions were independent of the surface area difference, but the rebound was greater in the smaller modules. The platelet (PLT) reductions were less with the 0.3-m2 PE module in comparison to those with the larger PE module, but no differences existed between both of the PVA modules. The smaller PVA module showed less complement activation compared to the 0.6-m2 module, whereas both of the PE modules showed comparable changes. Hemodynamic responses, especially the changes in pulmonary vascular resistance, were less with the smaller modules compared to the 0.6-m2 modules. The PE modules themselves showed less blood cellular, humoral, and hemodynamic changes compared to the PVA modules. The smaller modules showed greater rebound of WBC counts, however, PLT reductions, complement activation, and changes in hemodynamic parameters were less in the smaller modules.
- Published
- 1989
14. Radionuclide assessment of the natural heart ejection fraction before and after LVAD implantation
- Author
-
Napoli Ca, William A. Smith, Moritz A, Hiroaki Harasaki, Yukihiko Nosé, Uchida N, and Feiglin D
- Subjects
Male ,medicine.medical_specialty ,Blood pool ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Blood Pressure ,030204 cardiovascular system & hematology ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Animals ,Assisted Circulation ,Radionuclide Imaging ,Ejection fraction ,business.industry ,Ischemic injury ,Heart ,Stroke Volume ,General Medicine ,Myocardial function ,Blood pressure ,Cardiology ,Cattle ,Heart-Assist Devices ,business - Abstract
Complete pressure unloading of the ventricles can preserve ischemically damaged myocardium. Most clinical left heart assist device (LVAD) systems used after ischemic injury of the heart apply atrial cannulation which does not ensure pressure unloading. In order to assess the effect of the implantation of an intracorporeal LVAD on the function of the natural heart, we determined the ejection fraction (EF) in four male Holstein calves (90–105 kg) before and after insertion of a Cleveland Clinic pneumatic LVAD. A gated blood pool scan was obtained with a gamma camera after injection of 40 mCi Tc-labelled albumin. The animals were restrained in a sling to avoid movement artifacts. All animals showed a drop of 65 ± 12% to 42 ± 14% EF in the first postoperative (p.o.) week. Left ventricular output did not maintain sufficient blood pressure as assessed by pump-off tests. Systolic blood pressure dropped from 122 ±6.5 mm Hg to 81 ± 6 mm Hg without pump support on the morning of the first p.o. day. Apical coring and possible restrained heart movement by the implanted LVAD may lead to impaired myocardial function that renders the individual LVAD dependent until adaptative corrections take place.
- Published
- 1989
15. Haemorrhagic Activities of Habu Snake Venom, and their Relations to Lethal Toxicity, Proteolytic Activities and Other Pathological Activities
- Author
-
Ohsaka, A., Ikezawa, H., Kondo, H., Kondo, S., and Uchida, N.
- Subjects
Venoms ,Crotalid Venoms ,Animals ,Trimeresurus ,Articles ,Snake Venoms - Published
- 1960
16. Direct study on the formation of large defects in final stage of sintering in alumina ceramics
- Author
-
Sato, K., Satoshi Tanaka, Uchida, N., and Uematsu, K.
17. Deformation during sintering in alumina ceramic made using uniaxial pressing
- Author
-
Shui, Az, Satoshi Tanaka, Uchida, N., Uematsu, K., Suzuki, H., Komeya, K., and Sakai, M.
18. Direct observation of three-dimensional structure in powder compact
- Author
-
Saito, Y., Satoshi Tanaka, Uchida, N., and Uematsu, K.
19. Effects of mental workload on Visual Research while driving
- Author
-
Uchida, N., Dick de Waard, Karel Brookhuis, Katayama, T., Faculteit Gedrags- & Maatschappijwetenschappen, and Heymans Instituut (Psychologie)
20. Microstructural defects-strength relationship of silicon nitride ceramics
- Author
-
Hendrajaya, R., Satoshi Tanaka, Uchida, N., Uematsu, K., Mishra, B., and Yamauchi, C.
21. Odour measurement in wastewater treatment plant using both european and japanese standardized methods: Correlation and comparison study
- Author
-
Vincenzo Naddeo, Zarra, T., Kubo, A., Uchida, N., Higuchi, T., and Belgiorno, V.
- Subjects
EN13725:2003 ,Wastewater treatment plant ,dynamic olfactometry ,Human assessor ,sludge treatment
22. Characterization of effective mobility by split C-V technique in MoS2 MOSFETs with high-k/metal gate
- Author
-
Mori, T., Kubo, T., Uchida, N., Atsushi Ando, Ninomiya, N., Tanaka, M., Watanabe, E., Tsuya, D., Moriyama, S., and Ieee
23. Effects of PAA molecular weight on adsorption behavior of alumina slurry
- Author
-
Momota, M., Satoshi Tanaka, Uchida, N., Uematsu, K., and TTP
24. Slurry dispersion state as a parameter to control internal structure of alumina green compact
- Author
-
Saito, M., Shui, A., Satoshi Tanaka, Uchida, N., Uematsu, K., and TTP
25. Strength characteristics of binder-segregated granules
- Author
-
Kato, Z., Satoshi Tanaka, Uchida, N., Uematsu, K., Mishra, B., and Yamauchi, C.
26. Effect of powder characteristic on handling of powder, structures of green and sintered bodies of ceramics
- Author
-
Matsubara, N., Satoshi Tanaka, Uchida, N., Uematsu, K., and Kurita, T.
27. Differential expression of human telomerase-associated genes in human hematopoietic cells
- Author
-
Uchida, N., Otsuka, T., Shigematsu, H., Tomofusa Fukuyama, Maeda, M., Sugio, S., Itoh, Y., and Niho, Y.
28. Effect of particle orientation on the anisotropic sintering of alumina ceramics
- Author
-
Shui, A., Makiya, A., Satoshi Tanaka, Uchida, N., Uematsu, K., and Yokokawa, H.
29. Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers: an interethnic comparative study between Japanese and European volunteers
- Author
-
Jm, Gerven, Uchida E, Uchida N, Ms, Pieters, Aj, Meinders, Rik Schoemaker, Lv, Nanhekhan, Jm, Kroon, Sj, Visser, Altorf B, Yasuda K, Yasuhara H, and Af, Cohen
- Subjects
Adult ,Male ,Cross-Over Studies ,Adolescent ,Dose-Response Relationship, Drug ,Administration, Oral ,White People ,Europe ,Anti-Anxiety Agents ,Asian People ,Double-Blind Method ,Japan ,Humans ,Female ,Nitrazepam - Abstract
Potential interethnic differences in drug disposition and effects between Japanese and white subjects hamper the registration in Japan of medications already used in Western countries. This double-blind, placebo-controlled, crossover study was conducted to compare the pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam (5 mg) in age- and sex-matched Japanese (n = 8) and white (n = 8) healthy volunteers. The study was performed in centers in Japan and the Netherlands using the same methods and study design. Subjects were individually matched for gender, age, and body stature. Drug effects were measured by means of saccadic and smooth pursuit eye movements and visual analog lines obtained from the scales of Bond and Lader. There were no pharmacokinetic differences between the Japanese and white subjects. Clearance of nitrazepam was 0.91 +/- 0.165 mL/min/kg and 1.17 +/- 0.492 mL/min/kg, and half-life (t1/2) was 22.1 +/- 4.96 hours and 21.5 +/- 7.51 hours for the Japanese and European groups, respectively. Pharmacokinetic parameters showed no significant correlation with age, height, or weight. The average time-effect curves for the different parameters were comparable between groups. Compared with placebo, both groups showed similar significant reductions in average peak velocity and increases in saccadic inaccuracy and reaction time. Visual analog scores showed clear sedation in the white subjects, but insignificant effects in the Japanese subjects. Smooth pursuit did not change significantly in either group. Slope and intercept of the concentration-effect relationships for saccadic peak velocity showed considerable intersubject variability, but no clear differences between groups. The pharmacokinetics and pharmacodynamics of nitrazepam were similar in matched healthy Japanese and white subjects. Interethnic comparative studies are feasible, and provide meaningful information about potential racial differences in disposition and action of drugs. Such studies can form a rational basis for comparative clinical trials.
30. Effect of particle size distribution of primary particle on the characteristics of alumina ceramics
- Author
-
Satoshi Tanaka, Kato, Z., Uchida, N., and Uematsu, K.
31. Fast photo-induced phase switching in organic conductor crystal; (EDO-TTF)(2)PF6
- Author
-
Chollet, M., Guerin, L., Uchida, N., Fukaya, S., Ishikawa, T., Shinya Koshihara, Matsuda, K., Ota, A., Yamochi, H., Saito, G., Kobayashi, T., Okada, T., Nelson, Ka, and Desilvestri, S.
32. Effect of grinding on characteristics of alumina ceramics
- Author
-
Yonetani, S., Sato, K., Satoshi Tanaka, Uchida, N., and Uematsu, K.
33. Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group
- Author
-
Nemoto, K., Yamada, S., Nishio, M., Aoki, M., Nakamura, R., Matsumoto, Y., Sasamoto, R., Saitoh, Y., Takayama, M., Mitsuhashi, N., Gomi, K., Kanesaka, N., Kobayashi, M., Ohnishi, H., Sasaki, S., Tamamura, H., Mitsumori, M., Nishimura, Y., Kayoko Tsujino, Takemoto, M., Uchida, N., Yamamoto, M., Shioyama, Y., Hirakawa, K., and Ono, S.
- Subjects
Aged, 80 and over ,Male ,Salvage Therapy ,Esophageal Neoplasms ,Radiotherapy ,Brachytherapy ,Middle Aged ,Combined Modality Therapy ,Survival Rate ,Treatment Outcome ,Antineoplastic Combined Chemotherapy Protocols ,Practice Guidelines as Topic ,Carcinoma, Squamous Cell ,Humans ,Female ,Fluorouracil ,Cisplatin ,Aged - Abstract
Superficial esophageal cancer (SEC) is defined as esophageal cancer limited to the submucosal layers, including mucosal cancer and submucosal cancer, and is squamous cell carcinoma in most patients. In 2000, the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group for SEC published a consensus guideline of standard radiotherapy methods. In this study, the interim treatment outcomes of SEC patients, who had received radiation therapy following the standard radiotherapy methods, were investigated.From 2000 to 2003, a total of 141 SEC patients were treated in 24 institutions in Japan.The 1-, 2- and 3-year survival rates were 95%, 90% and 90%, respectively, for patients with mucosal cancer and 90%, 81% and 70%, respectively, for patients with submucosal cancer. The overall survival was better in patients who had undergone chemotherapy than in patients who had received radiation therapy alone, though the difference was not statistically significant. The clinical target volume (CTV) did not influence overall survival and intracavitary irradiation did not influence the local control rate in either patients with mucosal or submucosal cancer. Radiation-induced esophageal ulcer was not observed in this series.The standard radiotherapy methods are safe and effective for treating SEC. However, the usefulness of chemotherapy and intracavitary irradiation and the optimal setting of the CTV should be clarified by future randomized trials.
34. Kinetic effect of moisture on production of ceramics
- Author
-
Saito, Y., Satoshi Tanaka, Uchida, N., Uematsu, K., Mishra, B., and Yamauchi, C.
35. Particle orientation of alumina green body made by slip casting
- Author
-
Watanabe, S., Satoshi Tanaka, Uchida, N., and Uematsu, K.
36. Grain oriented microstructure made in high magnetic field
- Author
-
Makiya, A., Shouji, D., Satoshi Tanaka, Uchida, N., Kimura, T., and Uematsu, K.
37. Cadherins in brain patterning and neural network formation
- Author
-
Takeichi M, Tadashi UEMURA, Iwai Y, Uchida N, Inoue T, Tanaka T, and Sc, Suzuki
- Subjects
Embryonic and Fetal Development ,Mice ,Models, Neurological ,Synapses ,Animals ,Brain ,Nerve Net ,Cadherins ,Axons ,Body Patterning
38. Regulation of mRNA stability in eukaryotic cells
- Author
-
Uchida, N., Shinichi Hoshino, Katada, T., and Shyu, A. B.
39. Cytokine-mobilized peripheral blood CD34+Thy-1+Lin- human hematopoietic stem cells as target cells for transplantation-based gene therapy
- Author
-
Bp, Chen, Fraser C, Reading C, Murray L, Uchida N, Anne GALY, Sasaki D, Tricot G, Jagannath S, and Barlogie B
- Subjects
Adult ,Transplantation, Heterologous ,Hematopoietic Stem Cell Transplantation ,Antigens, CD34 ,Bone Marrow Cells ,Genetic Therapy ,Mice, SCID ,Thymus Gland ,HLA-A3 Antigen ,Flow Cytometry ,Hematopoietic Stem Cells ,Polymerase Chain Reaction ,Transplantation, Autologous ,Colony-Forming Units Assay ,Mice ,Fetus ,Antigens, CD ,Bone Marrow ,Neoplasms ,Animals ,Cytokines ,Humans ,Thy-1 Antigens ,Biomarkers - Abstract
Gene-therapy of blood-borne disorders may be best achieved using hematopoietic stem cells (HSC) which have extensive self renewal potential as well as multilineage repopulating potential as a cellular target. The human HSC, which is CD34+Thy-1+Lin- has been isolated from fetal, adult bone marrow and cytokine-mobilized peripheral blood (MPB) (1-3). Results presented in this study show that the degree of mobilization of HSC into peripheral blood of cancer patients is highly variable and that the combined use of high dose chemotherapy and GM-CSF as a mobilization strategy is superior to the use of G-CSF with regard to the mobilization of true HSC. A multistep cell isolation procedure has been developed which utilizes high speed flow-cytometric cell sorting and allows the isolation of sufficient numbers of HSC from MPB to permit their use as an hematopoietic graft for clinical transplantation. Hematopoietic stem cells isolated from MPB are capable of self-renewal and differentiation into multiple hematopoietic lineages as shown by their behavior in both in vitro and in vivo assays. Mobilized PB mononuclear cells isolated from cancer patients are frequently contaminated with tumor cells. Using this cell isolation procedure, HSC preparations from patients with multiple myeloma have been created with greatly reduced tumor cell burdens. These CD34+Thy-1+Lin- cells are capable of being stably transduced at high efficiency (32-75%) by co-culture on a cell line producing recombinant retroviruses containing the neomycin-resistant gene. These HSC cell populations are likely ideal targets for hematopoietic cell-based gene therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
40. Down-regulation of human telomeric protein TRF1 gene expression during myeloid differentiation in human hematopoietic cells
- Author
-
Otsuka, T., Uchida, N., Arima, F., Shigematsu, H., Tomofusa Fukuyama, Maeda, M., Sugio, Y., Itoh, Y., and Niho, Y.
41. Proliferative involvement of ENX-1, a human homolog of Drosophila enhancer of zeste, in human hematopoiesis
- Author
-
Otsuka, I., Tomofusa Fukuyama, Shigematsu, H., Uchida, N., and Niho, Y.
42. Anisotropic grain growth in uniaxially pressed alumina compacts
- Author
-
Shui, A., Saito, M., Satoshi Tanaka, Uchida, N., and Uematsu, K.
43. Influence of granules properties on the pressing
- Author
-
Saito, M., Satoshi Tanaka, Uchida, N., and Uematsu, K.
44. A novel method to investigate the non-uniformity of the internal structure of granule compact
- Author
-
Kato, Z., Satoshi Tanaka, Uchida, N., Uematsu, K., and TTP
45. Mid-infrared microscopy
- Author
-
Kato, Z., Sato, T., Satoshi Tanaka, Uchida, N., and Uematsu, K.
46. Influence of slurry pH on the compaction pressing of alumina ceramics
- Author
-
Saito, M., Shui, A., Tanaka, S., Lavelle, C., Thierry Poirier, Uchida, N., Lira, J., and Uematsu, K.
47. Compliance Effect on Patency of Small Diameter Vascular Grafts
- Author
-
Uchida, N., Emoto, H., Kambic, H., Harasaki, H., Chen, J. -F, Shan-hui Hsu, Murabayashi, S., and Nose, Y.
- Subjects
Carotid Arteries ,Dogs ,Anastomosis, Surgical ,Polyurethanes ,Graft Occlusion, Vascular ,Biophysics ,Animals ,Prosthesis Design ,Muscle, Smooth, Vascular ,Blood Vessel Prosthesis ,Compliance - Abstract
The compliance mismatch hypothesis as a cause of failure of small diameter grafts was investigated using 4 mm internal diameter, 5 cm long Biolized polyurethane grafts. The luminal surface of 0.5 mm thick Biomer sponge grafts was covered with 100 microns of crosslinked gelatin. Compliance matched, and noncompliant grafts had in vivo compliance values of 13.5 +/- 2.89 and 1.0 +/- 0.7 X 10(-2%) per mmHg, respectively. In vivo compliance defined as 2 X dD/dP X 1/Do was measured in situ using the ultrasonic Hokanson probe. Compliance values of compliant grafts equaled that of the canine carotid artery at 100 mmHg mean arterial pressure. Grafts were implanted using an end-to-end anastomosis in 14 dogs for 6 wk. Patency rates for compliant vs. noncompliant grafts were 64% (9/14) and 50% (7/14). Compliance values for compliant grafts decreased to a mean of 7.14 X 10(-2%) per mmHg. Anastomotic intimal hyperplasia at the proximal and distal ends of compliant and noncompliant grafts measured 239.9 +/- 128, 197 +/- 129 microns, 338.9 +/- 273.6, and 304.3 +/- 179.3 microns, respectively. There were no significant differences in localized anastomotic intimal hyperplasia at either graft end for either graft type. This study did not show any positive effects of graft compliance.
- Published
- 1989
48. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
- Author
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Clara Camaschella, Hong Ye, Manik C. Ghosh, Suh Young Jeong, Gennadiy Kovtunovych, Laura Silvestri, Naoya Uchida, John F. Tisdale, Tracey A. Rouault, Danilo Ortillo, Ye, H, Jeong, Sy, Ghosh, Mc, Kovtunovych, G, Silvestri, L, Ortillo, D, Uchida, N, Tisdale, J, Camaschella, Clara, and Rouault, Ta
- Subjects
Iron-Sulfur Proteins ,Erythroblasts ,Iron ,Ferroportin ,Molecular Sequence Data ,Heme ,Cytosol ,Sideroblastic anemia ,Glutaredoxin ,medicine ,Humans ,Amino Acid Sequence ,RNA, Small Interfering ,Glutaredoxins ,biology ,Sequence Homology, Amino Acid ,General Medicine ,Transfection ,Ferrochelatase ,medicine.disease ,ALAS2 ,Molecular biology ,Anemia, Sideroblastic ,Phenotype ,GLRX5 ,biology.protein ,Research Article ,5-Aminolevulinate Synthetase ,HeLa Cells - Abstract
Glutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a zebrafish model and of sideroblastic anemia in a human patient. Here we report that GLRX5 is essential for iron-sulfur cluster biosynthesis and the maintenance of normal mitochondrial and cytosolic iron homeostasis in human cells. GLRX5, a mitochondrial protein that is highly expressed in erythroid cells, can homodimerize and assemble [2Fe-2S] in vitro. In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload. Rescue of patient fibroblasts with the WT GLRX5 gene by transfection or viral transduction reversed a slow growth phenotype, reversed the mitochondrial iron overload, and increased aconitase activity. Decreased aminolevulinate delta, synthase 2 (ALAS2) levels attributable to IRP-mediated translational repression were observed in erythroid cells in which GLRX5 expression had been downregulated using siRNA along with marked reduction in ferrochelatase levels and increased ferroportin expression. Erythroblasts express both IRP-repressible ALAS2 and non-IRP-repressible ferroportin 1b. The unique combination of IRP targets likely accounts for the tissue-specific phenotype of human GLRX5 deficiency.
- Published
- 2010
49. End-functionalization of a vinylidene fluoride oligomer in coordination nanochannels
- Author
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Angiolina Comotti, Silvia Bracco, Noriyuki Uchida, Nobuhiro Yanai, Tetsuhiro Kodani, Piero Sozzani, Susumu Kitagawa, Takashi Uemura, Takashi Kanemura, Meiten Koh, Yanai, N, Uemura, T, Uchida, N, Bracco, S, Comotti, A, Sozzani, P, Kodani, T, Koh, M, Kanemura, T, and Kitagawa, S
- Subjects
Composite number ,General Chemistry ,CHIM/04 - CHIMICA INDUSTRIALE ,Oligomer ,CHIM/02 - CHIMICA FISICA ,chemistry.chemical_compound ,Elimination reaction ,chemistry ,Polymer chemistry ,Materials Chemistry ,Proton NMR ,Poorous coordinetion polymer, solid state NMR, end-functionalization ,Moiety ,Surface modification ,Carboxylate ,Fluoride - Abstract
The utility of basic sites of porous coordination polymers (PCPs) for the end-functionalization of oligo(vinylidene fluoride) (OVDF) is demonstrated. Densely arranged carboxylate moieties on the PCP pore walls act as basic sites and allow the efficient elimination reaction of the terminal group of OVDF to proceed. The progress of the reaction of an OVDF precursor in the PCP nanochannels was evidenced using solid state 19F NMR spectroscopy. From 19F and 1H NMR and IR measurements of the product isolated from the composite obtained, the terminal -CH2CF 2I moiety of OVDF was shown to be successfully converted to a -CHCF2 group. Because of the large surface area of the PCP materials, the OVDF precursor easily accessed the basic sites, resulting in a large increase in the rate of the elimination reaction. In addition, a notable effect of the porous structure of PCPs upon the elimination reaction was observed. © 2011 The Royal Society of Chemistry.
- Published
- 2011
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