1. Serial diffusion tensor imaging for early detection of radiation-induced injuries to normal-appearing white matter in high-grade glioma patients
- Author
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Tuva R, Hope, Jonas, Vardal, Atle, Bjørnerud, Christopher, Larsson, Marius R, Arnesen, Raimo A, Salo, and Inge R, Groote
- Subjects
Adult ,Male ,Brain Neoplasms ,Glioma ,Middle Aged ,Combined Modality Therapy ,White Matter ,Diffusion Tensor Imaging ,Case-Control Studies ,Image Interpretation, Computer-Assisted ,Anisotropy ,Humans ,Female ,Neoplasm Grading ,Radiation Injuries ,Aged - Abstract
To study the potential of diffusion tensor imaging (DTI) to serve as a biomarker for radiation-induced brain injury during chemo-radiotherapy (RT) treatment.Serial DTI data were collected from 18 high-grade glioma (HGG) patients undergoing RT and 7 healthy controls. Changes across time in mean, standard deviation (SD), skewness, and kurtosis of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λa ), and transversal diffusivity (λt ) within the normal-appearing white matter (NAWM) were modeled using a linear mixed-effects model to assess dose dependent changes of five dose bins (0-60 Gy), and global changes compared with a control group.Mean MD, λa and λt were all significantly increasing in41 Gy dose regions (0.14%, 0.10%, and 0.18% per week) compared with12 Gy regions. SD λt had significant dose dependent time evolution of 0.019*dose per week. Mean and SD MD, λa and λt in the global NAWM of the patient group significantly increased (mean; 0.06%, 0.03%, 0.09%, and SD; 0.57%, 0.34%, 0.51 per week) compared with the control group. The changes were significant at week 6 of, or immediately after RT.DTI is not sensitive to acute global NAWM changes during the treatment of HGG, but sensitive to early posttreatment changes.
- Published
- 2013