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International audience; AIM:The aim of this study was to review the evidence regarding the cardiovascular effects of urinary anticholinergic drugs in the elderly.METHODS:A literature review was conducted in October 2017 using the Medline/Pubmed database limiting the search to works in English or French.RESULTS:In total, 602 articles between March 1964 and October 2017 have been reported, 60 studies were analyzed, 19 were prospective trials. Geriatric population has a high prevalence of cardiovascular diseases (24.4% of heart diseases on 65-74years and 36.9% on ≥75years). More than 20% of the geriatric population has overactive bladder history and 41.43% of them use of antimuscarinic drugs. Evaluating the cardiovascular adverse effects of antimusarinics in the geriatric population is not easy because of exclusion of high-risk patients in trials. However, serious cardiovascular adverse effects were reported like atrial fibrillation, atrioventricular block or torsade de pointe. Further studies are needed especially in the "real life" in order to precise the exact prevalence of such cardiovascular alterations.CONCLUSION:Without conclusive evidence, potential cardiovascular adverse effects of anticholinergic agents used in overactive bladder must lead to a cautious prescription.

International audience; Overactive bladder symptoms (OAB) are frequent and can impact quality of life for these patients. Numerous and various treatments could be proposed in order to improve well-being and quality of life, but all these treatments have side effects and determine for many patients, important care constraints. We present here a review of food and diet in OAB.Material and methods: Literature review from PubMed Medline database and Google scholar to August 2016, without time restriction. Two hundred and ninety-six articles were screened, in English and in French, and finally, 10 were retained. HAS recommandation have been used for level of evidence.Results: On the 10 studies included, only two randomised controled trial were included. The first one showed decreases on urgency (by a half) (P = 0.02) and on frequency (by a third) (P = 0.035), secondary to reduction of caffeine consumption by a half after education [LE2]. The second randomized trial showed significant decreases on the first need to void in urodynamic study after caffeine consumption (170 mL vs. 210 mL) [LE2]. Feed like bread, chicken or nutrient like vitamin C or D were assessed in cohort or observational studies and appear as protective factors of OAB onset. Instead carbonated drinks may have a negative impact on symptoms, increasing urinary incontinence (OR 1.41 [95 % CI: 1.02–1.95]) [LE2], and there are contradictory results for alcohol consumption.Conclusion: Diet seems to have an impact on overactive bladder syndrome and particularly caffeine consumption, which increases storage symptoms.; Les troubles fonctionnels de l'hyperactivité vésicale (HAV) sont fréquents et impactent fortement la qualité de vie des patients. De nombreux traitements sont proposés pour améliorer le confort des patients mais l'utilisation de chacun d'entre eux pose un problème de tolérance, d'effets secondaires et de contrainte de soins. Nous avons réalisé une revue de la littérature sur l'action de l'alimentation sur l'HAV. Matériel et Méthodes : revue de la littérature à partir de PUBMED et Google Scholar, articles en Français et en anglais, sans restriction de date, jusqu'à Août 2016. Au total sur les 296 articles analysés, 10 ont été retenus, classés en niveaux de preuve selon les recommandations HAS d'avril 2013. Résultats : Parmi les études retenues, on retrouve 2 essais contrôlés randomisés. Le premier retrouvait une diminution de 61% des urgenturies (p=0,02) et de 35% pour la pollakiurie (p=0,035) suite à la diminution de moitié de la consommation de café après éducation [NP1]. Le second retrouvait une diminution significative du besoin d'uriner en étude urodynamique après ingestion de caféine (170ml vs 210ml) [NP2]. A partir d'analyses longitudinales, d'autres aliments comme le pain, le poulet ou des nutriments (vitamine C ou D) sont retrouvés comme facteurs protecteurs de la survenue d'HAV, au contraire des boissons gazeuses qui favorisent l'apparition de ces symptômes (OR 1,41 (95%, CI 1,02-1,95)) [NP2]. Les résultats concernant la consommation d'alcool sont discordants. Conclusion : L'alimentation semble avoir un impact sur les symptômes d'HAV et notamment la consommation de caféine qui augmente les symptômes urinaires irritatifs.