1. Splenectomy prior to experimental induction of autoimmune hepatitis promotes more severe hepatic inflammation, production of il-17 and apoptosis
- Author
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Buitrago-Molina, Laura Elisa, Dywicki, Janine, Noyan, Fatih, Trippler, Martin, Pietrek, Julia, Schlue, Jerome, Manns, Michael P., Wedemeyer, Heiner, Jaeckel, Elmar, and Hardtke-Wolenski, Matthias
- Subjects
caspase-3 ,autoimmune hepatitis ,formiminotransferase cyclodeaminase ,Communication ,apoptosis ,Medizin ,adenovirus ,liver ,digestive system diseases ,Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Gastroenterologie und Hepatologie und Transplantationsmedizin ,IL-17 ,inflammation ,spleen ,ddc:610 ,experimental murine hepatitis - Abstract
Autoimmune hepatitis (AIH) is detected at a late stage in the course of the disease. There-fore, induction and etiology are largely unclear. It is controversial if the induction of autoimmunity occurs in the liver or in the spleen. In our experimental murine AIH model, the induction of autoimmunity did not occur in the spleen. Instead, a protective role of the spleen could be more likely. Therefore, we splenectomized mice followed by induction of experimental murine AIH. Splenectomized mice presented more severe portal inflammation. Furthermore, these mice had more IL-17, IL-23 receptor (IL-23R) and caspase 3 (casp3) and a decreased amount of erythropoietin in serum, while intrahepatic T cell compartments were unaffected. These results indicate that the spleen is not necessary for induction of AIH, and splenectomy disrupts the ability to immune regulate the intensity of hepatic inflammation, production of IL-17 and apoptosis. OA Förderung 2021
- Published
- 2021