1. Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction
- Author
-
Nam Nhut Phan, Chih Yang Wang, Yi-Yin Do, Tran Duong Thuy, Han-Gang Yu, Yen Chang Lin, Shu Yin Wang, and Pung-Ling Huang
- Subjects
Blood Glucose ,Male ,0301 basic medicine ,Cardiac function curve ,Cancer Research ,Administration, Oral ,Blood Pressure ,Cardiomegaly ,Dioxoles ,030204 cardiovascular system & hematology ,Pharmacology ,Hypoglycemia ,Bioinformatics ,Biochemistry ,Lignans ,Streptozocin ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,Electrocardiography ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Heart Rate ,Sesamin ,Diabetes mellitus ,Genetics ,medicine ,Animals ,Molecular Biology ,Type 1 diabetes ,cardiac dysfunction ,diabetes ,business.industry ,Myocardium ,Body Weight ,Heart ,Articles ,medicine.disease ,Streptozotocin ,Rats ,Cardiovascular physiology ,030104 developmental biology ,Blood pressure ,Oncology ,chemistry ,Molecular Medicine ,business ,medicine.drug - Abstract
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.
- Published
- 2017