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45 results on '"Toxicokinetics and Metabolism"'

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1. Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

2. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages

3. Sex-dependent dynamics of metabolism in primary mouse hepatocytes

4. Assessment of the potential vaping-related exposure to carbonyls and epoxides using stable isotope-labeled precursors in the e-liquid

5. Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry

6. Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study

7. Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

8. Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide

9. Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells

10. Cross-species analysis of hepatic cytochrome P450 and transport protein expression

11. Determination of aflatoxin M1 and deoxynivalenol biomarkers in infants and children urines from Bangladesh

12. Is adipose tissue suitable for detection of (synthetic) cannabinoids? A comparative study analyzing antemortem and postmortem specimens following pulmonary administration of JWH-210, RCS-4, as well as ∆9-tetrahydrocannabinol to pigs

13. Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast

14. Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague–Dawley rats

15. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice

16. New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite ('M-12')

17. Human metabolism and kinetics of the UV absorber 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328) after oral administration

18. Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro

19. Physiology-based toxicokinetic modelling of aluminium in rat and man

20. Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

21. In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids

22. Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS

23. The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

24. The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes

25. In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation

26. Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids

27. Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR)

28. Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

29. Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

30. Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors

31. Correction to: Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

32. Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data

33. Bioavailability of cyanide after consumption of a single meal of foods containing high levels of cyanogenic glycosides: a crossover study in humans

34. Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days

35. Physiologically based kinetic modeling of the bioactivation of myristicin

36. Hair analysis for the biomonitoring of pesticide exposure: comparison with blood and urine in a rat model

37. Acute liver effects, disposition and metabolic fate of [

38. Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation

39. Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

40. Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions

41. The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

42. Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study

43. Xenobiotic metabolism in differentiated human bronchial epithelial cells

44. Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys

45. Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling

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