1. Advances in understanding the biology and function of the G-CSF receptor
- Author
-
de Koning Jp and Touw Ip
- Subjects
Neutropenia ,Myeloid ,Acute myeloblastic leukemia ,Growth factor ,medicine.medical_treatment ,Hematology ,Biology ,medicine.disease ,Hematopoiesis ,Leukemia, Myeloid, Acute ,medicine.anatomical_structure ,Cytokine ,Cell surface receptor ,Receptors, Granulocyte Colony-Stimulating Factor ,Immunology ,medicine ,Animals ,Humans ,Congenital Neutropenia ,Receptor ,Function (biology) - Abstract
G-CSF is the major growth factor involved in the production of neutrophilic granulocytes. G-CSF exerts its function via the activation of a membrane receptor that belongs to the super-family of hematopoietin receptors, also referred to as class I cytokine receptors. In this review we summarize the current knowledge of the function of the G-CSF receptor in normal granulopoiesis, as well as in some patients with severe congenital neutropenia and acute myeloblastic leukemia, diseases characterized by disturbed myeloid maturation.
- Published
- 1996
- Full Text
- View/download PDF