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我が国のソーシャルワーク実践が今後どのような視座を携え，人々をその苦しみから救うことができるのか。日本の文化や風土の影響を享けつつも時代のなかで一定の貢献をしてきた仏教哲学・仏教教義が，ソーシャルワーク実践にどのような課題を発信してきたのかについて，引続き日本仏教社会福祉学会年報に掲載された研究論文等を解題することを通して整理・検討していった。

コンクリートピット埋設施設は、支持能力を有する地盤に設置する必要があると考えられることから、地下水面より下位に設置することが想定される。そのため、施設の設置環境(施設の周辺岩盤)及び施設の構造物(コンクリートピット埋設施設及びこれを取りまくベントナイト混合土)のそれぞれの透水係数をパラメータとしてモデル計算を行い、施設への浸入水量及び施設からの浸出水量を評価した。地下水流動解析は、有限要素法による2次元地下水流動解析コードMIG2DFを用いて行った。設置環境を考慮した評価では、これまでの技術検討で施設底面における地下水浸入水量及び浸出水量が相対的に多量となったことから、その底面と接する新鮮な岩盤の透水係数をパラメータとして、地下水浸入水量及び浸出水量の評価を実施した。また、施設の構造物を考慮した評価では、コンクリートピット埋設施設の経年的な劣化及びベントナイト混合土の化学的な変質による劣化を想定したコンクリート及びベントナイト混合土の透水係数を設定し、地下水の浸入水量及び浸出水量の変化を評価した。その結果、岩盤新鮮部の透水係数は施設における地下水浸入水量及び浸出水量に大きく寄与することが分かった。また、ベントナイト混合土の化学的劣化に伴う透水係数の増加に伴い、その周囲の覆土へ移行する浸出水量が増加する結果となった。以上からこれらの透水係数は、コンクリートピット埋設施設の設置及び安全評価における重要な影響因子であることが分かった。, Concrete vault disposal facility is assumed to be installed below the groundwater table because it is necessary to install them on the ground that has enough bearing capacity. Therefore, the flow rates of groundwater into and out of concrete vault were evaluated by taking into account the permeability coefficients of the geological environment surrounding the facility and of the engineered structure of the facility. Groundwater flow analysis was performed by using the groundwater flow analysis code MIG2DF based on finite element method. In the evaluation of considering the geological environment, since the flow rate of groundwater into and out of the bottom of concrete vault was larger than the flow rates into and out of other sides of the vault in previous technical studies, the evaluation of the flow rate was performed by varying the permeability coefficient of the bedrock adjacent to the bottom of concrete vault. In addition, the other evaluation of the flow rate was conducted assuming the deterioration of concrete vault and of bentonite-mixed soil. As a result, it was found that the permeability coefficient of bedrock adjacent to concrete vault greatly contributed to flow rates of groundwater into and out of concrete vault. In addition, as the permeability coefficient of the bentonite-mixed soil increased due to chemical deterioration, the flow rate of leachate into the surrounding cover soil increased. From the above results, it was found that these permeability coefficients were important influencing factors in the engineering design and safety evaluation of concrete vault disposal facilities.

Parthenogenesis is suppressed in rice egg cells to avoid precocious development before fertilization. We found that cold treatment released cell cycle arrest in egg cells and triggered mitosis. Egg cells isolated fromjaponica(Nipponbare; NB) andaus(Kasalath; KS) subspecies divided and regenerated into mature plants after cold treatment. The egg-derived plants showed variety of ploidy levels, including haploid (n), diploid (2n), and tetraploid (4n). Nuclear DNA quantification showed that genome duplication occurred during early parthenogenetic development. Owing to the presence of single nucleotide polymorphisms (SNPs) between NB and KS, inter-subspecific hybrid plants (NB-KS hybrids) were created via electrofusion. Egg cells from the NB-KS hybrid developed parthenogenetically into polyploid plants. 2n and 4n plants originating from the same NB-KS egg cell displayed the same homozygous SNP patterns throughout the genome, indicating that these plants were doubled and quadrupled haploids. Transcriptome analyses of cold-treated egg cells demonstrated that parthenogenesis-related candidate genes, includingOsBBML1, were upregulated.

Subthreshold micropulse laser (SMPL) is more clinically efficient for the treatment of diabetic macular edema (DME) than the conventional continuous-wave (CW) laser. We aimed to characterize transcriptome changes after the application of these lasers and to compare the transcripts.Human pluripotent stem cell-derived retinal pigment epithelial cells were exposed to laser irradiation. Differentially expressed genes (DEGs), distribution of heat shock protein (Hsp) family, gene expression profile, and gene ontology (GO) enrichment analysis based on RNA sequencing data were investigated at 3 h and 24 h after irradiation.CW laser induced more DEGs than SMPL (1771 vs. 520 genes). The expression of the Hsp family was confirmed in both groups: however, the induction patterns was different for different genes. GO enrichment analysis revealed that CW laser upregulated the expression of DEGs involved in vasculature development (GO: 0001944), related to apoptosis and repair after cell injury whereas SMPL upregulated the expression of DEGs involved in photoreceptor cell maintenance (GO: 0045494), photoreceptor cell development (GO: 0042461), and sensory perception of light stimuli (GO: 0050953).The results provide insights into the genetic responses and may contribute to the understanding of the molecular mechanisms of laser-induced thermal effects.

Supplementary Table. S6. Comparison of gene mutations between the study cohort and the TCGA cohort

This report delivers a comprehensive genetic alteration profile of lung adenocarcinomas (LADC) driven by ALK, RET, and ROS1 oncogene fusions. These tumors are difficult to study because of their rarity. Each drives only a low percentage of LADCs. Whole-exome sequencing and copy-number variation analyses were performed on a Japanese LADC cohort (n = 200) enriched in patients with fusions (n = 31, 15.5%), followed by deep resequencing for validation. The driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling complex genes than in other LADCs (P < 0.0001). This lower mutation rate was independent of age, gender, smoking status, pathologic stage, and tumor differentiation (P < 0.0001) and was validated in nine fusion-positive cases from a U.S. LADCs cohort (n = 230). In conclusion, our findings indicate that LADCs with ALK, RET, and ROS1 fusions develop exclusively via their dependence on these oncogene fusions. The presence of such few alterations beyond the fusions supports the use of monotherapy with tyrosine kinase inhibitors targeting the fusion products in fusion-positive LADCs. Cancer Res; 75(11); 2264–71. ©2015 AACR.

Supplementary Fig. S4. Infrequent occurrence of gene aberrations in fusion-positive LADCs in a US cohort

Supplementary Fig. S1. Sequencing depth and estimated tumor content

Supplementary Table. S7. Amplification of nine representative oncogenes in the study cohort

Supplementary Table. S1. Comparison of clinical and pathological characteristics between the NCC cohort and the study cohort

Supplementary Fig. S5. Number of non-synonimous mutations according to tumor content in pan-negative cases

Supplementary Table. S4. Univariate and multivariate regression analysis of numbers of non-synonymous mutations per Mb and clinical characteristics between driver fusion, driver mutation and pan-negative cases

Supplementary Table. S3. Top 50 significantly mutated genes deduced by MutSigCV analysis

Supplementary Fig. S6. Mutation spectra and frequencies by driver aberration and smoking status

Supplementary Table. S2. Clinical and pathological characteristics of the 608 lung adenocarcinomas of the NCC cohort

Supplementary Table. S8. Gene mutations detected by deep resequencing in 29 pan-negative cases

Supplementary Table. S5. Mutation frequency of the 127 SMGs for 20 cellular processes in the study and TCGA cohort

Supplementary Fig. S3. Gene mutation frequency by driver aberration

Ischemia-reperfusion (I-R) injury is damage caused by restoring blood flow into ischemic tissues or organs. This complex and characteristic lesion accelerates cell death induced by signaling pathways such as apoptosis, necrosis, and even ferroptosis. In addition to the direct association between I-R and the release of reactive oxygen species and reactive nitrogen species, it is involved in developing mitochondrial oxidative damage. Thus, its mechanism plays a critical role via reactive species scavenging, calcium overload modulation, electron transport chain blocking, mitochondrial permeability transition pore activation, or noncoding RNA transcription. Other receptors and molecules reduce tissue and organ damage caused by this pathology and other related diseases. These molecular targets have been gradually discovered and have essential roles in I-R resolution. Therefore, the current study is aimed at highlighting the importance of these discoveries. In this review, we inquire about the oxidative damage receptors that are relevant to reducing the damage induced by oxidative stress associated with I-R. Several complications on surgical techniques and pathology interventions do not mitigate the damage caused by I-R. Nevertheless, these therapies developed using alternative targets could work as coadjuvants in tissue transplants or I-R-related pathologies

我が国のソーシャルワークが今後どのような視座を携え，人々をその苦しみから救うことができるのか。日本の文化や風土の影響を享けつつ今までの時代のなかで一定の貢献をしてきたアジア型援助原理に相当する仏教哲学・仏教教義が，ソーシャルワークにどのような課題を発信してきたのかについて，日本仏教社会福祉学会年報に掲載された研究論文を解題するなかで整理し検討していった。

The most common connection type in mass timber construction is wood–steel–wood dowel-type connections, which are semi-rigid. A model for moment–rotation ( M  − ) relationships of dowel-type connections is required to account for their semi-rigidity in analyses using beam elements. This study develops a numerical model for non-linear M  − relationships under fire conditions (non-linear M  − model) that considers the temperature and plasticisation of dowels and timber. This paper also introduces a theoretical model for linear elastic M  − relationships (linear M − model), which provides the basis of the non-linear M  − model. The numerical model divides dowels into a series of elements on an elastoplastic foundation and performs a direct stiffness method in a time incremental procedure, using an element stiffness matrix derived from beam-on-elastic-foundation theory. The theoretical model agreed well with the ambient test result in the elastic range, and the numerical model corresponded to the fire test results. The three numerical analyses where the dowels are considered to be rigid, linear elastic and elastoplastic bodies are also performed. These three results converged to the same value after 65 min of heating, which suggests that the ultimate states of beams with dowel-type connections exposed to fire can be modelled by assuming that dowels are rigid bodies.

The behavior of the concentrated compressive load applied to the narrow face of cross-laminated timber (CLT) panels is an essential parameter in the design of multi-story timber buildings. Therefore, this paper presents a methodology to evaluate the strength and stiffness of the concentrated compressive load on the narrow face of the CLT. The methodology accounts for the effects of side margins, CLT directions, and CLT composition. In this methodology, a dented shape at the surface of CLT resulting from loading, which has an important role in the behavior of the concentrated compressive load applied to the narrow face, is examined via finite element (FE) analysis. The reproducibility of the FE models is verified experimentally. The proposed methodology is then used to predict the yield stress and Young’s modulus of the concentrated compressive load on the narrow face of the CLT panels using equations, which were proposed based on the exponential function curves. The calculated values of the yield stress and Young’s modulus obtained by the equations based on the exponential function curves considering the effects of the out-of-plane deformations in the outermost laminae were similar to the experimental results of previous studies.

To reduce the immunogenicity of β-lactoglobulin (BLG), we prepared recombinant BLG which has both site-specific glycosylation and single amino acid substitution (D28N/P126A), and expressed it in the methylotrophic yeast Pichia pastoris by fusion of the cDNA to the sequence coding for the α-factor signal peptide from Saccharomyces cerevisiae. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) analysis indicated that the D28N/P126A was conjugated with a ∼4 kDa high-mannose chain. D28N/P126A retained ∼61% of the retinol-binding activity of BLG. Structural analyses by circular dichroism (CD) spectra, intrinsic fluorescence, and Enzyme-linked immunosorbent assay (ELISA) with monoclonal antibodies indicated that the surface structure of BLG was slightly changed by using protein engineering techniques, but D28N/P126A was covered by high-mannose chains and substituted amino acid without substantial disruption of native conformation. Antibody responses to the D28N/P126A considerably reduced in C57BL/6 mice. We conclude that inducing both site-specific glycosylation and single amino acid substitution simultaneously is an effective method to reduce the immunogenicity of BLG.

Background: Muscle wasting, also known as myopenia, is frequent in rheumatoid arthritis (RA). To date, it is still unknown if the failure of pharmacologic therapies increases the risk of myopenia in RA. Objective: To identify if treatment failure with conventional synthetic DMARDs (csDMARDs) constitutes an independent risk factor of muscle wasting in women with RA. Methods: This was a cross-sectional study. We included 277 women with RA. Assessments in RA patients included: clinical, epidemiological, and therapeutic variables. The skeletal muscle index (SMI) was estimated by DXA, and myopenia was diagnosed if they had an SMI < 5.45 kg/m2. Multivariable logistic regression models identified risk factors of myopenia. Results: Muscle wasting was observed in 28.2% of patients with RA. The risk factors of myopenia in RA were menopausal (OR: 4.45, 95% CI: 1.86 to 10.64) and failure of combined therapy with csDMARDs (OR: 2.42, 95% CI: 1.15 to 5.07). The increased body mass index was protective (OR:0.81, 95% CI: 0.75 to 0.87). Conclusions: Around one of four patients with RA presented muscle wasting. Muscle wasting is related to treatment failure of combined csDMARDs; other factors influencing the presence of muscle wasting is being postmenopausal, whereas, the body mass index was a protective factor.

Tumor-induced osteomalacia (TIO) is a rare tumor-associated syndrome in which osteomalacia is induced by a tumor. A 67-year-old male patient presented for the first time with low back pain, weakness of the lower extremities and difficulty in walking. Six years earlier, he had nonspecific symptoms such as low back pain, and blood tests showed high alkaline phosphatase and low phosphorus. In addition, fibroblast growth factor 23 (FGF23) was abnormally high at 454 pg/mL. A diagnosis of FGF23-related hypophosphatemic osteomalacia was made. Somatostatin receptor scintigraphy, venous sampling and MRI were performed to localize and diagnose TIO. The tumor was found to be confined to the right femoral head and hemiarthroplasty was performed. Pathological examination revealed a phosphaturic mesenchymal tumor. Postoperatively, symptoms and blood test data improved. Although resection of the lesion and osteochondral transplantation or total hip arthroplasty were considered, hemiarthroplasty was chosen over concerns about treatment failure due to seeding.

Ruptured retinal arterial macroaneurysm (RAM) can cause sub-inner limiting membrane (ILM) hemorrhage, leading to acute vision loss in the elderly. Vitrectomy has been established as an effective treatment to remove hemorrhage and facilitate visual recovery. Although optical coherence tomography (OCT) is useful for the diagnosis of sub-ILM hemorrhage before surgery, little is known about the postoperative OCT findings. Here, we retrospectively investigated the records of nine eyes of nine patients who underwent surgery for sub-ILM hemorrhage due to RAM rupture. On postoperative OCT, hyperreflectivity throughout the full thickness of the central fovea was observed in eight eyes (88.9%), and disruption of the ellipsoid/interdigitation zone (EZ/IZ) was observed in seven out of eight eyes (87.5%). The widths of the hyperreflectivity and EZ disruption gradually decreased. Visual recovery was least favorable in two eyes, in which the EZ line continuation did not recover until the final follow-up. The OCT findings corresponded to the hemorrhagic staining identified on fundus photographs in at least four eyes; as per the fundus photographs the findings persisted even after the hemorrhage was absorbed. In contrast, the OCT findings resembled the appearance before the development of a full-thickness macular hole, suggesting fragility caused by the RAM rupture.

Several aromatic amine compounds are urinary bladder carcinogens. Activated metabolites and DNA adducts of polycyclic aromatic amines, such as 4-aminobiphenyl, have been identified, whereas those of monocyclic aromatic amines, such as

We study the ground-state properties of the SU(N)-generalization of the Kondo-lattice model in one dimension when the Kondo coupling J_K (both ferromagnetic and antiferromagnetic) is sufficiently strong. Both cases can be realized using alkaline-earth-like cold gases in optical lattices. Specifically, we first carry out the strong-coupling expansion and identify two insulating phases (one of which is the SU(N)-analogue of the well-known gapped Kondo singlet phase). We then rigorously establish that the ground state in the low-density (for J_K0) region is ferromagnetic. The results are accounted for by generalizing the double-exchange mechanism to SU(N) "spins". Possible realizations of Bose-Fermi supersymmetry SU(N|1) in the (generalized) SU(N) Kondo-lattice model are discussed as well., 21 pages, 13 figures, final version

We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs. We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s.

A 74-year-old man with a history of transfusion at 35 years old in Egypt was referred to our hospital. He was infected with hepatitis C virus (HCV) genotype 4 (GT4), which is a rare HCV GT in Japan, and was also diagnosed with hepatic compensated cirrhosis. We safely treated the patient for 12 weeks with the combination of glecaprevir and pibrentasvir, and a sustained virologic response (SVR) was achieved. This is the first report of HCV GT4 infection in a treatment-naïve Japanese patient with cirrhosis in whom SVR was achieved with the combination treatment of glecaprevir and pibrentasvir.

This annual review is the sixth of its kind since 2016 (see references). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation and bioactivation. These fields are constantly evolving with new molecular structures and discoveries of corresponding pathways for metabolism that impact relevant drug development with respect to efficacy and safety. Based on the selected articles, we created three sections: (1) drug design, (2) metabolites and drug metabolizing enzymes, and (3) bioactivation and safety (Table 1). Unlike in years past, more biotransformation experts have joined and contributed to this effort while striving to maintain a balance of authors from academic and industry settings.[Table: see text]. ispartof: DRUG METABOLISM REVIEWS vol:53 issue:3 pages:384-433 ispartof: location:England status: published

This paper describes results and analysis of experimental testing of entire and partial compression strength and stiffness parallel to the grain of solid timber (Japanese cedar). To investigate the spreading effects, the size effect of strength and stiffness, and the mechanism of the damage zone located close to the loading plates, tests on 90 specimens were performed. As a result, it was observed that damage zones existed near the loading plates. The observed spreading effects in the compression parallel to the grain were very small which justifies neglecting them regarding strength and stiffness. Although a presence of a size effect of the compression strength parallel to the grain of glulam specimens with knots was reported, the compression strength parallel to the grain of solid wood specimens without knots does not have a size effect. The height and width of the cross-section of the specimens have an influence on the damage zones and, hence, on the effective modulus of elasticity of the full height of the specimens. The compression strength has a correlation with the density of the timber and the width of the annual rings.

The CRISPR-Cas9 method for generation of knock-in mutations in rodent embryos yields many F0 generation candidates that may have the designed mutations. The first task for selection of promising F0 generations is to analyze genomic DNA which likely contains a mixture of designed and unexpected mutations. In our study, while generating Prlhr-Venus knock-in reporter mice, we found that genomic rearrangements near the targeted knock-in allele, tandem multicopies at a target allele locus, and mosaic genotypes for two different knock-in alleles occurred in addition to the designed knock-in mutation in the F0 generation. Conventional PCR and genomic sequencing were not able to detect mosaicism nor discriminate between the designed one-copy knock-in mutant and a multicopy-inserted mutant. However, by using a combination of Southern blotting and the next-generation sequencing-based RAISING method, these mutants were successfully detected in the F0 generation. In the F1 and F2 generations, droplet digital PCR assisted in establishing the strain, although a multicopy was falsely detected as one copy by analysis of the F0 generation. Thus, the combination of these methods allowed us to select promising F0 generations and facilitated establishment of the designed strain. We emphasize that focusing only on positive evidence of knock-in can lead to erroneous selection of undesirable strains.

To reduce the immunogenicity of β-lactoglobulin (BLG), we prepared single amino acid substituted recombinant BLG mutants (BLG/P126A, BLG/V128D and BLG/D129A) in the methylotrophic yeast

Translucent skin is an attribute widely appreciated by people in East Asian countries. There have been studies in the literature to describe the phenomenon by means of clinical grading, instrumental measurement and image analysis. However, due to its subjective and complex nature, skin translucency has not been comprehensively and rigorously characterized and modelled, particularly in the Chinese population. This study is to develop a mathematical model that quantitatively describes skin translucency from visual cues objectively measured from the skin.The study was designed to characterize and model skin translucency by incorporating expert evaluation, panel perception and image analysis of multiple skin visual attributes in one analysis. Faces of 36 Chinese females aged 18-65 years old were evaluated by a dermatologist to obtain clinical translucency scores. Subject pairs were formed with a relatively high and low translucency score in each pair. Their faces were judged in person by 9 panellists in paired-comparison (2-AFC) fashion to pick a 'more translucent skin' from each subject pair. Front-view facial images of the subjects were taken, and multiple colour and other visually perceivable skin attributes were measured using image analysis. Bradley-Terry analysis and multiple regressions were performed to correlate the panel choices of 'more translucent skin' with the objectively measured skin parameters.Multiple skin colour properties affected the panel choices towards translucent skin. Among them skin tone lightness and skin glossiness had positive effects on skin translucency while the hue, colour unevenness, severity of red and dark spots affected it negatively. Subsurface light reflection and skin visual smoothness had some effect but were not statistically significant. A mathematical model was constructed to predict a person's skin translucency from objectively measured skin attributes.The subjective property of skin translucency can be characterized and quantified via a comprehensive modelling process involving clinical grading, panel evaluation, image-based measurement of skin attributes and statistical analysis. A novel skin parameter, Skin Translucency Index (STI) was established, which provides a way to measure skin translucency, making it possible to assess treatment efficacy before and after product application.La peau translucide est un attribut largement apprécié dans les pays d’Asie de l'Est. Des études ont été menées dans la littérature pour décrire ce phénomène au moyen d'une classification clinique, d'une mesure instrumentale et d'une analyse d’images. Cependant, en raison de sa nature subjective et complexe, la translucidité de la peau n'a pas été caractérisée et modélisée de manière exhaustive et rigoureuse, en particulier dans la population chinoise. Cette étude vise à développer un modèle mathématique qui décrit quantitativement la translucidité de la peau à partir de repères visuels objectivement mesurés sur la peau. MATÉRIELS ET MÉTHODES: L’étude a été conçue pour caractériser et modéliser la translucidité de la peau en intégrant l'évaluation des experts, les perceptions d’un panel et l’analyse d’images de multiples attributs visuels de la peau dans une seule analyse. Les visages de 36 femmes chinoises âgées de 18 à 65 ans ont été évalués par un dermatologue afin d’obtenir des scores de translucidité clinique. Des paires de sujets ont été formées, chaque paire ayant un score de translucidité relativement élevé et faible. Leurs visages ont été jugés en personne par 9 panellistes en comparaison appariée (2-AFC) pour choisir une « peau plus translucide » pour chaque paire de sujets. Des images des visages des sujets de face ont été prises, et des attributs liés aux couleurs et d’autres attributs cutanés perceptibles visuellement ont été mesurés par une analyse des images. Une analyse de Bradley-Terry et des régressions multiples ont été réalisées pour corréler les choix de « peau plus translucide » par le panel avec les paramètres cutanés mesurés objectivement. RÉSULTATS: Plusieurs propriétés liées à la couleur de peau ont influencé les choix du panel vers une peau translucide. Parmi celles-ci, la pâleur du teint et la brillance de la peau ont eu des effets positifs sur la translucidité de la peau, tandis que la teinte, l’inégalité de la couleur, la sévérité des taches rouges et foncées ont exercé une influence défavorable. La réflexion de la lumière sous la surface et la douceur de la peau perçue visuellement ont eu un certain effet, mais n’étaient pas statistiquement significatives. Un modèle mathématique a été construit pour prédire la translucidité de la peau d’une personne à partir d’attributs cutanés mesurés objectivement.La propriété subjective de la translucidité de la peau peut être caractérisée et quantifiée via un processus de modélisation complet comprenant une classification clinique, une évaluation par un panel, une mesure basée sur les images d'attributs cutanés et une analyse statistique. Un nouveau paramètre cutané, l’indice de translucidité de la peau (ITP), a été établi, qui fournit un moyen de mesurer la translucidité de la peau, permettant d’évaluer l’efficacité du traitement avant et après l’application du produit.

This paper describes results and analysis of experiment of compression behavior parallel to grain of glulam (Norway Spruce, Japanese cedar, and Japanese cypress), especially in damage zones near loading plates and joints. To investigate the influence factors of physical properties and the mechanism of the damage zone near the loading plates or the joints, compression tests on 90 specimens and surface-measurement tests on 48 specimens were performed. As a result, it was observed that damage zones existed near the loading plates and the joints. The lengths of the damage zone of wood–wood joints are larger than that of wood–steel joints. The length of the damage zone was independent of the load and the height of the specimens. However, the length of the damage zone and its scatter increase as the width of the cross-section increases, as does the roughness on the contact surface. It was considered that the cause of the damage zone is the roughness on the contact surface and the length of the damage zone depends on the roughness on the contact surface. Therefore, the length of the damage zone depends on the processing accuracy on the contact surface and has an increasing trend as the contact-surface area increases. There was the size effect of the height of the specimens on the compressive strength because of knots.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening disorders characterized by widespread epidermal necrosis of the skin and mucosa. The severity-of-illness scoring system for TEN (SCORTEN) was widely used since 2000 as a standard prognostic tool consisting of seven clinical values. Methods: To evaluate the prognosis using current treatments and risk factors for mortality, we retrospectively analyzed 59 cases of TEN, including SJS/TEN overlap treated in two university hospitals from January 2000 to March 2020. Results: The mortality rate of TEN was 13.6% (8/59). All patients treated with high-dose steroid administration in combination with plasma exchange and/or immunoglobulin therapy recovered. Logistic regression analysis showed nine clinical composite scores, namely: heart rate (≧120 bpm), malignancy present, percentage of body surface area with epidermal detachment (>10%), blood urea nitrogen (>28 mg/dL), serum bicarbonate level (252 mg/dL), age (≧71 years), the interval between disease onset and treatment initiation at the specialty hospital (≧8 days), and respiratory disorder within 48 h after admission. The receiver operating characteristic curves confirmed a high potential for predicting the prognosis of TEN. Conclusions: Recent developments in treatment strategies have contributed to the improved prognosis of TEN patients. A modified severity scoring model composed of nine scores may be helpful in the prediction of TEN prognosis in recent patients. Further large-scale studies are needed to confirm mortality findings to improve prognostication in patients with TEN.

Seafloor massive sulphide (SMS) deposits, modern analogues of volcanogenic massive sulphide (VMS) deposits on land, represent future resources of base and precious metals. Studies of VMS deposits have proposed two emplacement mechanisms for SMS deposits: exhalative deposition on the seafloor and mineral and void space replacement beneath the seafloor. The details of the latter mechanism are poorly characterised in detail, despite its potentially significant role in global metal cycling throughout Earth’s history, because in-situ studies require costly drilling campaigns to sample SMS deposits. Here, we interpret petrographic, geochemical and geophysical data from drill holes in a modern SMS deposit and demonstrate that it formed via subseafloor replacement of pumice. Samples from the sulphide body and overlying sediment at the Hakurei Site, Izena Hole, middle Okinawa Trough indicate that sulphides initially formed as aggregates of framboidal pyrite and matured into colloform and euhedral pyrite, which were replaced by chalcopyrite, sphalerite and galena. The initial framboidal pyrite is closely associated with altered material derived from pumice, and alternating layers of pumiceous and hemipelagic sediments functioned as a factory of sulphide mineralisation. We infer that anhydrite-rich layers within the hemipelagic sediment forced hydrothermal fluids to flow laterally, controlling precipitation of a sulphide body extending hundreds of meters.