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Low-dimensional ferroelectric tunnel junctions are appealing for the realization of nanoscale nonvolatile memory devices due to their inherent advantage of device miniaturization. Those based on current mechanisms still have restrictions including low tunneling electroresistance (TER) effects and complex heterostructures. Here, we introduce an entirely new TER mechanism to construct the nanotube ferroelectric tunnel junction with ferroelectric nanotubes as the tunneling region. When rolling a ferroelectric monolayer into a nanotube, due to the coexistence of its intrinsic ferroelectric polarization with the flexoelectric polarization induced by bending, there occurs metal-insulator transition depending on radiative polarization states. For the pristine monolayer, its out-of-plane polarization is tunable by an in-plane electric field, the conducting states of the ferroelectric nanotube can thus be tuned between metallic and insulating via axial electric means. Using {\alpha}-In2Se3 as an example, our first-principles density functional theory calculations and nonequilibrium Green's function formalism confirm the feasibility of the TER mechanism and indicate an ultrahigh TER ratio exceeding 9.9*10^10% of the proposed nanotube ferroelectric tunnel junctions. Our findings provide a promising approach based on simple homogeneous structures for high density ferroelectric microelectronic devices with excellent ON/OFF performance., Comment: 15 pages, 5 figures

Objectives. Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequencing. Methods. This work examined immune cell abundance in normal and MI samples from GSE109048 and determined differences in the activated mast cells and activated CD4 memory T cells, resting mast cells. Weighted gene coexpression network analysis (WGCNA) demonstrated that activated CD4 memory T cells were the most closely related to the turquoise module, and 10 hub genes were screened. Single-cell sequencing data (scRNA-seq) of MI were examined. We used t -distributed stochastic neighbor embedding ( t -SNE) for cell clustering. Results. We obtained 8 cell subpopulations, each of which had different marker genes. 7 out of the 10 hub genes were detected by single-cell sequencing analysis. The expression quantity and proportion of the 7 genes were different in 8 cell clusters. Conclusion. In general, our study revealed the immune characteristics and determined 7 prognostic markers for MI at the single-cell level, providing a new understanding of the molecular characteristics and mechanism of MI.

An accurate modal analysis of the stepped rotor assembly is significant in the design process of rotors. The transfer matrix method (TMM) is widely used in the modal analysis of the rotor. However, the influences of the step and the assembling modes are not considered in the traditional TMM. In this paper, a modified transfer matrix method is presented for the modal calculation of the rotor in the turbomolecular pump. The stiffness reduction of stepped segments and the effect of assembled components are considered in this modified method. First of all, the traditional transfer matrix model is built. Then, the stepped segments of the rotor are changed into conical segments and the lumped mass model of conical segments is calculated. Next, the conicities of conical segments are analyzed and relations between conicities and dimensions of the rotor are discovered. Finally, the stiffness factors which can describe the effects of different assembling modes are introduced and optimized. The optimized stiffness factors are analyzed and explained from the perspective of contact stress. The modal of the stepped rotor assembly could be computed with high accuracy by using this method.

A network meta-analysis was conducted to evaluate the renal protective effect and safety of sodium-glucose cotransporter-2 inhibitors in patients with chronic kidney disease and type 2 diabetes mellitus.PubMed, Embase, Cochrane Library, and Web of Science were searched by two authors using the Cochrane Collaboration risk of bias tool.Compared with controls, luseogliflozin 2.5 mg (MD = - 3.50, 95% CI - 6.65 to - 0.35), bexagliflozin 20 mg (MD = - 3.48, 95% CI - 6.57 to - 0.39), and dapagliflozin 10 mg (MD = - 3.08, 95% CI - 5.09 to - 1.06) reduced the estimated glomerular filtration rate (eGFR). Empagliflozin 25 mg (MD = - 240.43, 95% CI - 414.13 to - 66.73), dapagliflozin 10 mg (MD = - 94.15, 95% CI - 111.72 to - 76.59), and canagliflozin 100 mg (MD = - 193.25, 95% CI - 279.16 to - 107.34) reduced urine albumin-creatinine ratio levels compared with controls. Empagliflozin 25 mg, canagliflozin 100 mg and dapagliflozin 10 mg induced a significant decline in urine albumin-creatinine ratio compared to dapagliflozin 5 mg. In terms of safety, ertugliflozin 5 mg reduced the risk of urinary tract infection. Compared with controls, empagliflozin 10 mg and 25 mg, and canagliflozin 100 mg reduced the risk of any adverse events while canagliflozin 100 mg reduced the risk of serious adverse events. Dapagliflozin 10 mg had a lower risk of treatment discontinuation.Sodium-glucose cotransporter-2 inhibitors have favourable renal protective effect and safety; however, additional randomised clinical trials are needed to validate these findings.

InGaN light-emitting diodes (LEDs) grown with an asymmetric multiple quantum well (MQW) are proposed for use in an optical link with an avalanche photodiode (APD) based receiver. In contrast to the high photoresponse of red AlGaInP LEDs in APDs, the proposed blue LEDs provide improved light output and enhanced system bandwidth for directed line-of-sight optical links passing through a 100-cm-long water tank. This improvement is due to the nonuniform carrier distribution within the InGaN MQWs being mitigated by using a thin GaN barrier near the n-GaN to facilitate hole transport capacity. In addition, bandwidth degradation resulting from APD module saturation can also be avoided by using these blue LEDs, successfully establishing a 300 Mbit/s LED-based underwater data link. The proposed InGaN LEDs (zero bias) under illumination exhibit a peak responsivity of 0.133 at λ = 370 nm, an ultraviolet (UV)-to-visible rejection ratio of 4849 and a 3-dB cut-off frequency of 33.3 MHz. Using violet UV laser diodes and the proposed LEDs respectively as the optical transmitter and receiver, an underwater optical link (L = 100 cm) with a data transmission rate of up to 130 Mbit/s and a bit error rate of 4.2 × 10−9 is also demonstrated.

Fifth generation (5G) mobile communication systems have entered the stage of commercial development, providing users with new services and improved user experiences as well as offering a host of novel opportunities to various industries. However, 5G still faces many challenges. To address these challenges, international industrial, academic, and standards organizations have commenced research on sixth generation (6G) wireless communication systems. A series of white papers and survey papers have been published, which aim to define 6G in terms of requirements, application scenarios, key technologies, etc. Although ITU-R has been working on the 6G vision and it is expected to reach a consensus on what 6G will be by mid-2023, the related global discussions are still wide open and the existing literature has identified numerous open issues. This paper first provides a comprehensive portrayal of the 6G vision, technical requirements, and application scenarios, covering the current common understanding of 6G. Then, a critical appraisal of the 6G network architecture and key technologies is presented. Furthermore, existing testbeds and advanced 6G verification platforms are detailed for the first time. In addition, future research directions and open challenges are identified for stimulating the on-going global debate. Finally, lessons learned to date concerning 6G networks are discussed.

Photothermal slippery surface has broad applications in many research fields for noncontacting, loss-free, and flexible droplet manipulation capability. In this work, with specific morphologic parameters and modified base materials doped by Fe3O4, a high-durability photothermal slippery surface (HD-PTSS) was proposed and implemented based on ultraviolet (UV) lithography to achieve repeatability of more than 600 cycles. The instantaneous response time and transport speed of HD-PTSS were related to near-infrared ray (NIR) powers and droplet volume. Meanwhile, the durability was closely related to the morphology of HD-PTSS, which impacts the recovering of a lubricant layer. The droplet manipulation mechanism of HD-PTSS was discussed in depth, and the Marangoni effect was found to be the key factor for the durability of HD-PTSS.

Uncertainty in quality and the inspectors' imperfect testing capability leave raw agricultural products (e.g., fresh produce, seafood, livestock and poultry products, etc.) wide open to economically motivated adulteration (EMA), and the strong demand for online shopping of these products in China makes this situation even worse. In this paper, we develop a game-theoretic framework to investigate online raw agricultural product sellers' preemptive EMA behavior on an ecommerce platform (EP). Particularly, the sellers differ from each other in the original quality of their products. We characterize the sellers' equilibrium pricing and adulteration decisions and the EP's optimal take rate decision, and analyze how the sampling inspections and adulteration penalty jointly impact these decisions. Moreover, we investigate three managerial levers, such as claiming a higher-than-law-requires penalty, that the administrative departments or the EP can use to deter EMA. Finally, we use the real-word data from Taobao.com to calibrate our model and derive more managerial insights from the analytical findings. We find that the heterogenous sellers' adulteration decisions are symmetric and their ex-post pricing decisions lead them to evenly share the market on the EP. Interestingly, we show that the EP's higher take rate will inhibit the sellers' adulteration behavior. However, the profit-maximizing EP may indulge the sellers' adulteration behavior by intentionally decreasing this rate. Our results highlight a penalty-inspection-centered approach as essential to combat EMA, and the three levels can play a role as supplements to this approach under certain conditions.

Myostatin (MSTN) regulates muscle development and body metabolism through a variety of pathways and is a core target gene for gene editing in livestock. Gut fungi constitute a small part of the gut microbiome and are important to host health and metabolism. The influence of MSTN mutations on bovine gut fungi remains unknown. In this study, Internal Transcribed Spacer (ITS) high-throughput sequencing was conducted to explore the composition of gut fungi in the MSTN mutant (MT) and wild-type (WT) cattle, and 5,861 operational taxonomic units (OTUs) were detected and classified into 16 phyla and 802 genera. The results of the alpha diversity analysis indicated that no notable divergence was displayed between the WT and MT cattle; however, significant differences were noticed in the composition of fungal communities. Eight phyla and 18 genera were detected. According to the prediction of fungal function, saprotroph fungi were significantly more abundant in the MT group. The correlation analysis between gut fungal and bacterial communities revealed that MSTN mutations directly changed the gut fungal composition and, at the same time, influenced some fungi and bacteria by indirectly regulating the interaction between microorganisms, which affected the host metabolism further. This study analyzed the role of MSTN mutations in regulating the host metabolism of intestinal fungi and provided a theoretical basis for the relationship between MSTN and gut fungi.

The significant nutation will degrade the stability of high-speed magnetically levitated turbo-rotor system. This article presents a damping optimization method to suppress the nutation mode. The proposed method consists of two parts: nutation compensation and damping optimization. The nutation compensation with the cross-channel displacement signal is designed in detail to increase the damping force of nutation mode in the first part. The root locus of the closed-loop rotor system is used to analyze the effect of damping compensation. The control parameters are iterated to configure the pole of the nutation mode with the goal of making the rotor system have the optimal damping ratio at the nutation mode. Finally, simulation results show that the nutation damping ratio of the rotor system with the proposed method is greater than 0.658, and the experiment results on a magnetically levitated turbomolecular pump prototype validate that the proposed damping optimization method can effectively suppress the nutation mode and its power spectrum level is below $-$ 60 dB over the entire speed range.

The formation of magnetosomes inside magnetotactic bacteria is a complex process strictly controlled by the intracellular metabolic regulatory system. A series of transcriptional regulators are involved in the biosynthesis of the magnetosome, including OxyR-Like protein, which is indispensable for the maturation of magnetosomes in Magnetospirillum Gryphiswaldense MSR-1. In this study, a new function of the OxyR-Like protein that helps cells resist reactive oxygen species (ROS) was identified. A comparison of expression profile data between wild-type MSR-1 and an oxyR-Like defective mutant demonstrated that seven genes encoding chemotaxis proteins were down-regulated in the latter. On the contrary, the expression levels of numerous genes encoding proteins that are critical for cellular aerobic respiration were up-regulated. Thus, OxyR-Like enhanced the resistance of cells to ROS by increasing their environmental perception and maintaining their oxidative phosphorylation at a reasonable level to avoid the excessive production of endogenous ROS. These results increase our knowledge of the OxyR-Like regulatory network and establish a relationship between the antioxidant metabolic pathway and magnetosome biomineralization in MSR-1.

ObjectiveWe investigated the effects of COVID-19 fear on negative moods among college students, and assessed the efficacy of physical exercise behavior as a moderator variable.MethodsThis was a cross-sectional study. Students from three colleges and universities in Shangqiu City, Henan Province and Yangzhou City, Jiangsu Province were enrolled in this study, which was performed during the COVID-19 pandemic using an online questionnaire. A total of 3,133 college students completed the questionnaire. Measurement tools included the COVID-19 Phobia Scale (C19P-S), Depression-Anxiety-Stress Self-Rating Scale (DASS), and the Physical Activity Behavior Scale (PARS-3).ResultsDuring the COVID-19 pandemic, the rates of depression, anxiety, and stressful negative moods among college students were 35.5, 65.5, and 10.95%, respectively; there was a positive correlation between COVID-19 fear and negative moods among college students (r = 0.479, p < 0.001), which was negatively correlated with physical exercise behavior (r = −0.4, p < 0.001); the regulating effects of physical exercise behavior were significant (ΔR2 = 0.04, p < 0.001).ConclusionThe rate of negative moods among college students is high, and the fear for COVID-19 is one of the key factors that lead to negative moods. Physical exercise can modulate the impact of COVID-19 fear among college students on negative moods. Studies should elucidate on mental health issues among different populations during the COVID-19 pandemic.

This scoping review aims to provide a synthesis of the available literature on behavioural and implementation science research in Asian healthcare settings.

Due to the air gap between stator and rotor, magnetically suspended control moment gyro (MSCMG) should be equipped with locking/unlocking device (LUD) to sustain launch vibration and impact. Current LUDs are not repeatable, reliable and compact enough for gyro applications. In this paper, a repeatable locking/unlocking device (RLUD) with several elastic brackets as clamping/releasing mechanism is proposed. Based on the equivalent beam model, static and dynamic analyses of the brackets are carried out, and the maximum stress, the locking/unlocking force and the resonance frequency are obtained. Subsequently, the optimization design using non-linear programming by quadratic Lagrangian (NLPQL) algorithm is implemented, and structural parameters of the optimized brackets are calculated. The maximum stress and first resonance frequency are simulated through finite element method (FEM), and the results are in good agreement with those of the elastic beam analyses. Finally, a MSCMG rotor system with the designed RLUD is fabricated. The environmental mechanics tests including sine sweep and random vibration are performed, which verifies the locking protection effect for MSCMG rotor.

Roller clinching is a variation of conventional clinching by using rotational tool movement. The joining quality of roller clinching is significantly affected by tooling geometries and motions. Considering the formation difference of joints at different locations, this paper investigated the deformation features of roller clinching of square joints and utilized multiple linear regression analysis to optimize the processing parameters. It was found that roller geometry has significant impact on the formation of interlocks of the front/rear sides of joints, while the impact on the formation of lateral sides is less. With the increase of roller diameters, the clearance variation of front/rear sides decreases; meanwhile, the separation clearance s at the front side after forming decreases. In the study, when the roller diameter is raised from 35 to 150 mm, the connection strength increases by 44%. If the diameter difference w of rollers increases, the squeezing degree of the front side decreases, and the joining quality increases; however, if the squeezing degree of the rear side increases, then the joining quality of the rear side and s decrease. In the sample, an increase in w by 3 mm enhanced the connection strength by 9%. When the clearance difference t between the rollers increases, the capability to contain metal increases in the rear side. When t increases by 0.6 mm, the connection strength augments by 12%. The separation clearance s of the front side is greatly affected by friction μ, roller diameter, w, and draft angle γ of the lower roller, while the effect of draft angle β of the upper roller on s is small.

Graphical abstract The experimental results show that the better attitude stabilization precision and the fast response speed benefit from the contactless suspension and active controllability of the axial-radial integrated AMA system, and it is potential to be applied in the airborne remote sensing system to improve the measurement accuracy., Highlights • A novel structure of AMA system is designed and constructed, and the axial control and radial control are integrated in the AMA system. • The magnetic forces and the gimbal torques of the axial-radial integrated AMA system have good actively controllability and linearity. • The good tracking performance of the AMA system is experimentally verified, and mid-frequency disturbance is effectively suppressed., Introduction The inertial stabilization platform (ISP) is widely used in the earth observation system to stably track the line of sight of the payload because it could isolate vibrations and angular motions of the aviation platform. Objectives an active magnetic actuator (AMA) system integrating the axial and the radial control is used to levitate the azimuth gimbal to improve attitude stabilization precision and dynamic performance of the ISP, and then the dynamic model of azimuth gimbal is developed. Methods The magnetic force and the gimbal torque of the axial-radial integrated AMA system are investigated, and the attitude information of the suspended azimuth gimbal is measured. Results The attitude stabilization precision of azimuth gimbal is confined at 0.02°, and the control bandwidth of the axial-radial integrated AMA system could exceed 100 Hz. Conclusion the ISP with an axial-radial integrated AMA system has better attitude stabilization precision and wider control frequency than the pure mechanical ISP, so it is potential to be applied in the airborne remote sensing system to improve the measurement precision.

Brain magnetic resonance imaging (MRI) findings in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with clinical characteristics, and evaluate their predictive power for disease recurrence and prognosis.We retrospectively extracted the clinical data and brain MRI findings of 144 patients with NMDAR encephalitis. Patients underwent a 2-year follow-up to assess disease outcomes. We evaluated the associations of brain MRI findings at the onset with clinical characteristics, recurrence, and prognosis.Initial MRI showed typical abnormalities in 65 patients (45.1%); of these, 34 (29.3%) developed recurrence and 10 (9.4%) had poor prognosis (mRS ≥3). Binary logistic regression analyses revealed that insula abnormalities were associated with acute seizure (odds ratio [OR] = 3.048, 95% confidence interval [CI]: 1.026-9.060) and white matter lesions were associated with cognitive impairment (OR = 2.730, 95% CI: 1.096-6.799). Risk factors for a poor 2-year prognosis included a higher number of brain MRI abnormalities (OR = 1.573, 95% CI: 1.129-2.192) and intensive care unit (ICU) admissions (OR = 15.312, 95% CI: 1.684-139.198). The risk factors for 2-year recurrence included abnormalities of the thalamus (HR = 3.780, 95% CI: 1.642-8.699).Brain MRI features of patients with NMDAR encephalitis were associated with clinical manifestations, prognosis, and recurrence. Higher numbers of MRI abnormalities and ICU admissions were predictive of poor prognosis. Abnormalities of the thalamus constituted a recurrence-related risk factor.

This review aims to present an updated systematic overview of the barriers and facilitators, and effective interventions that can promote immunisation uptake by older people in Australia, Singapore, Indonesia and the Philippines

Background: Preeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast to the impact of hypoxia on the placenta and fetus, comparatively little is known on the maternal physiology. Methods: We adopted an integrative approach to investigate the inter-relationship between chronic hypoxia during pregnancy with maternal, placental and fetal outcomes, common in preeclampsia. We exploited a novel technique using isobaric hypoxic chambers and in vivo continuous cardiovascular recording technology for measurement of blood pressure in sheep and studied the placental stress in response to hypoxia at cellular and sub-cellular levels. Results: Chronic hypoxia in ovine pregnancy promoted fetal growth restriction with evidence of fetal brain-sparing, increased placental hypoxia-mediated oxidative damage and activated placental stress response pathways. These changes were linked with dilation of the placental endoplasmic reticulum cisternae and increased placental expression of the antiangiogenic factors sFlt-1 and sEng, combined with a shift towards an angiogenic imbalance in the maternal circulation. Chronic hypoxia further led to an increase in uteroplacental vascular resistance, and the fall in maternal blood pressure with advancing gestation measured in normoxic pregnancy did not occur in hypoxic pregnancy. Conclusions: Therefore, we show in an ovine model of sea level adverse pregnancy that chronic hypoxia recapitulates physiological and molecular features of preeclampsia in the mother, placenta and offspring.

Autophagy has been proved to play a vital role in cardiac hypertrophy. The present study was designed to investigate the relationship between miR-100-5p and autophagy in the development of cardiac hypertrophy. Here, miR-100-5p expression was detected in abdominal aortic coarctation (AAC)-induced cardiac hypertrophy rats and Angiotensin II (Ang II)-stimulated cardiomyocytes. In vitro and in vivo experiments were performed to explore the function of miR-100-5p on autophagy and cardiac hypertrophy. We also investigated the mechanism of miR-100-5p on autophagy with dual-luciferase reporter assays, RNA immunoprecipitation (RIP), quantitative real-time PCR (qRT-PCR), western blot, immunofluorescence, and transmission electron microscopy (TEM). The results showed that miR-100-5p was highly expressed in hypertrophic hearts and Ang II-induced cardiomyocytes. Overexpression of miR-100-5p promoted the expression of cardiac hypertrophy markers ANP, BNP and β-MHC and cell surface area, while those were suppressed by miR-100-5p inhibitor. Knockdown of miR-100-5p by antagomiR significantly improves cardiac function and attenuate cardiac hypertrophy in vivo. Mechanistic investigation has found that miR-100-5p promote autophagy by targeting mTOR. Inhibition of autophagy by 3-methyladenine (3-MA) or mTOR overexpression could reverse the function of miR-100-5p in cardiac hypertrophy. These results elucidate that miR-100-5p promoted the pathogenesis of cardiac hypertrophy through autophagy activation by targeting mTOR.

Introduction The perceived health benefits and effectiveness of electronic cigarettes (e-cigarettes) in quitting smoking may affect e-cigarette usage, however, research on the use of e-cigarettes among the Chinese, especially among the rural Chinse, is scarce. This study examined factors associated with perceptions of e-cigarette related harms, benefits, and addictiveness, among smoker and non-smoker households with children in rural China, to support the design of populationbased interventions targeting rural Chinese households. Methods In a cross-sectional study design, using a structured questionnaire, we collected data from the household members of children in two selected rural communities in China. Descriptive analyses were used to characterize respondents; χ 2 test and Fisher’s exact probability test were used to compare the perceptions of e-cigarettes between different sociodemographic groups. Logistic regression was used to determine predictors for e-cigarette harms, benefits, and addictiveness, adjusting for demographic and other characteristics. Results The overall participation rate was 81% (1211/1498). Of the participants, 668 (55%) were smokers and 543 (45%) were non-smokers; 53% knew about e-cigarettes. Participants from rural Dali (77% vs 59%), those who were ethnic minority (76% vs 59%), those who perceived increased COPD risks from smoking (mean score 4.37 vs 4.18) and concerned about harmful effects of secondhand smoke (SHS) exposure to children (mean score 4.48 vs 4.30) and adults (mean score 4.06 vs 3.87) were more likely to believe that e-cigarettes were less harmful (p

Precipitation is particularly scarce in arid Central Asia (CA), and is expected to be severely impacted by future warming, and the assessment of the stationarity of precipitation variability is important for managing surface water resources in this region. In this study, we investigated the statistics of stationarity in the totals and extremes of precipitation in CA based on the longest observational records (1881–2006), tree-ring reconstructed records (1756–2012 and 1760–2015), and the Coupled Model Intercomparison Project 5 (CMIP5) simulations, applying the autocorrelation function and testing criteria established based on the statistical definitions of stationarity. We analyzed the longest daily precipitation record (Tashkent station, 1881–2006) and found that the autocorrelation coefficient of the precipitation totals (PRCPTOT) and annual maximum 1-day precipitation amount (Rx1day) were statistically insignificant for all lags, implying stationary behavior. Regionally, nearly all the Global Historical Climatology Network-Daily Database (GHCN-D) observatory sites (1925–2005) indicated likely stationary behavior. The reconstructed records were also indistinguishable from a random process. For the CMIP5 models, the simulated and projected PRCPTOT closely approximated a purely random process; however, the projected Rx1day maintained non-stationary means in most of the models under the representative concentration pathway (RCPs), implying that extreme events would increase in the future. The mean precipitation changes (ΔP) can be expressed as an exponential function depending on the length of the successive mean periods ( μ ) and variance ( σ 2 ). The ΔP of the next decade is projected to be within ±14.8% of the previous decades mean annual PRCPTOT over CA. The higher the RCPs, the higher the ΔP over CA. The results show that the detection and prediction of precipitation change will be challenging in arid CA.

Given both the popularity of street vendors and the government resistance to them in tourism governance, we interview vendors between September 2014 and May 2021 to gain insights into the interactions and conflicts between vendors, local enterprises and government departments in Canton, China. We derive a theory of ‘He Wei Gui’ from Chinese Confucian culture and adopt discourse analysis to investigate how informal tourism photography vendors in the Canton Tower Scenic Area resolve their conflicts. We argue that photography vendors have developed a harmonious but fragile coexistence through the use of measures such as fuzzification of public space, flexible industry regulations, output of emotional capital and normalised ways, thereby demonstrating the business acumen of little people. In contrast to the existing trend of ‘rigid governance’, the authors suggest applying ‘flexible management’ in the informal economy and tourism governance, and giving prominence to the principal role of informal operators or little people. In addition, this flexible management reflects the tacit consent from all the stakeholders, the active suing for nonviolent solution from the vulnerable and the willingness of modifying or even creating rules for balancing the distribution of the interests from the dominant stakeholder. The key to this flexible management is that authorities take the investment of emotional capital of the vulnerable groups into consideration. This leads to fuzzy governance which blurs and integrates emotions into the rules, making it possible to solve the conflicts in a more flexible way.

BACKGROUND Acute pancreatitis is the leading cause of hospitalization for acute gastrointestinal disease worldwide. The effects of probiotics in mild acute pancreatitis have not been studied. We hypothesized that the administration of probiotics may accelerate the recovery of intestinal function and shorten the length of hospital stay (LOS) in patients with mild pancreatitis. AIM To investigate the value of probiotics in reducing the LOS in patients with mild acute pancreatitis. METHODS We conducted a double-blind randomized clinical trial to evaluate the effects of probiotics administered to patients with mild acute pancreatitis at a tertiary medical center. The patients were given probiotics capsules (a mixed preparation of Bacillus subtilis and Enterococcus faecium) or placebo. The primary study endpoint was the LOS. The secondary endpoints included time to abdominal pain relief, recurrent abdominal pain, and time to successful oral feeding. RESULTS A total of 128 patients were included, with 64 patients in each arm. The severity of illness and the etiological distribution of disease were similar in the two groups. There was a significant reduction in the LOS in the probiotics treatment group vs the placebo group (5.36 ± 0.15 vs 6.02 ± 0.17 d, P < 0.05). The probiotics group was associated with a shorter time to abdominal pain relief and time to successful oral feeding (P < 0.01 for both) than the placebo group. No statistical difference was found in recurrent abdominal pain between the two groups. CONCLUSION The study results showed that the administration of probiotics capsules is associated with a shorter duration of hospitalization in patients with mild acute pancreatitis.

The feasibility of using InGaN/GaN multiple-quantum-well light-emitting diode arrays (LED arrays) as photodiodes (PDs) is investigated experimentally in addition to their light emitting function. Two discrete LED arrays are produced from one 4 × 4 LED array with a parallel-connected pixel configuration. Such compact designs are useful for light emission or detection at the transmitting/receiving terminals of optical wireless communication systems. Despite 4 × 2 LED arrays achieving a light output power of 67.4 mW at 250 mA, they exhibit an optical responsivity (detectivity) of 0.183 A/W (1.61 × 1012 cm Hz1/2W−1) under ultraviolet light illumination (λ = 380 nm) at zero bias. For 4 × 2 LED arrays, the presence of an appreciable ultraviolet light response, together with a high 3-dB bandwidth (∼8 MHz) for modulated light detection, allowed us to build a 15 Mbit/s directed optical link with these LEDs functioning as both the optical transmitter and the receiver. Finally, the unitary LED array-based optical link is capable of real-time transmission of digital audio signals (data rate = 6 Mbit/s) at a propagation distance of 100 cm in free space even though some of the constituent pixels are inactive for light detection.

This study focuses on the efficiency of message-passing-based decoding algorithms for polar and low-density parity-check (LDPC) codes. Both successive cancellation (SC) and belief propagation (BP) decoding algorithms are studied {in} the message-passing framework. Counter-intuitively, SC decoding demonstrates the highest decoding efficiency, although it was considered a weak decoder {in terms of} error-correction performance. We analyze the complexity-performance tradeoff to dynamically track the decoding efficiency, where the complexity is measured by the number of messages passed (NMP), and the performance is measured by the statistical distance to the maximum a posteriori (MAP) estimate. This study offers a new insight into the contribution of each message passed in decoding, and compares various decoding algorithms on a message-by-message level. The analysis corroborates recent results on terabits-per-second polar SC decoders, and might shed light on better scheduling strategies.

The Yellow River is the main water source for both local industrial and agricultural use, and the main source of local drinking water as well. In this study, eight water samples of Baotou region were analyzed, in which the heavy metal (Cd, Zn, Cu, Pb, Cr, Hg and As) content were detected using plasma-mass spectrometry and reduction gasification-atomic fluorescence spectrometry. Genus of water bacteria in eight water samples were investigated by means of high-throughput sequencing. Results showed that all the contents of heavy metals exceed GB (GuoBiao) standard of China, which implied the water of the Yellow River in Baotou region are at risk of being polluted. Furthermore, a large number of conditioned pathogens (Flavobacterium, Pseudomonas, Acinetobacter and Chryseobacterium) were found, some bacteria (such as Methanobacteria) can break down harmful substance and organic matter. In conclusion, according to this study, we try to put forward an important reference for the pollution control of Yellow River in Baotou region.

Ultra-large plate forgings are foundation of heavy machinery, but many parts of the type cannot be made by conventional technologies due to the characters of extreme manufacturing in terms of size and quality requirements. This paper introduced a systematically method called cylinder unfolding method (CUM) for producing large plate forgings, by using a serial of operations including “splitting”, “unfolding”, and “flattening” of a thick cylinder obtained from saddle forging. The technological route of CUM was presented in detail with an example of plate forging with the horizontal sizes of 6100 mm and thickness of 300 mm. The deformation features of saddle forging for fabricating transitional cylinders were analyzed, and then the subsequent handling steps including splitting, unfolding and flattening of the cylinder, as well as the auxiliary processing, were addressed. The practice proved that CUM can provide an efficient way for manufacturing ultra-large plate forgings and meet the strict requirements in geometry and mechanical performance, without highly increasing the investments of forming equipment and tooling.

Corporate social responsibility (CSR) decisions of small tourism entrepreneurs have received limited attention from existing studies. This study applies the management concept of ‘job embeddedness’...

Phenotype switch of vascular smooth muscle cells (VSMCs) plays an important role in the development of atherosclerosis (AS). Endothelial cells can regulate VSMC phenotypic switch by secreting exosomes, crucial mediators of intracellular communication. This study aimed to determine whether exosomal LINC01005 from oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs) plays a role in regulating VSMC phenotypic switch and to validate the underlying molecular mechanism. Exosomes were extracted from ox-LDL-treated HUVECs (ox-LDL-Exo) and then administered into VSMCs. VSMC phenotypic switch was assessed by determining VSMC phenotypic markers using western blot. VSMC cell proliferation and migration were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and wound healing assay, respectively. The interaction between miR-128-3p and LINC01005 or Krüppel-like factor 4 (KLF4) was analyzed by luciferase reporter assay. ox-LDL-Exo contained high expression of LINC01005. Inhibition of LINC01005 expression in ox-LDL-Exo abrogated the ox-LDL-Exo-induced VSMC phenotypic switch, proliferation, and migration. Furthermore, LINC01005 acted as a sponge of miR-128-3p to upregulate KLF4 expression. Moreover, miR-128-3p overexpression and KLF4 silencing in VSMCs attenuated the ox-LDL-Exo-induced VSMC phenotypic switch, proliferation, and migration. Collectively, exosomal LINC01005 from ox-LDL-treated HUVECs promotes VSMC phenotype switch, proliferation, and migration by regulating the miR-128-3p/KLF4 axis.

Microwave-assisted leaching as a green and efficient method for leaching chalcopyrite has attracted increasing attention. Researchers have actively explored the reasons why microwaves have a positive impact on copper extraction. In this work, X-ray diffraction (XRD), an optical microscope, electron probe micro-analyzer (EPMA) and field emission scanning electron microscope with energy dispersive spectrometer (SEM-EDS) were employed to investigate the surface structure modification of chalcopyrite by microwave during leaching. The modified chalcopyrite had a positive effect on better mineral leachability, higher effective surface for leaching, and the fewer passivation layer. The superior mineral leachability was related to the surplus intermediate products of covellite, while microwave promoted the conversion of chalcopyrite to covellite. In addition, microwave is capable of increasing active sites upon the removal of the passivation layer and the enlargement of the effective reaction surface. This work summarized the relationship between the high copper recovery and the surface structure modification of chalcopyrite systematically. Keywords: Microwave-assisted leaching, Chalcopyrite, Modification, Surface structure, Passivation layer

The permanent magnet linear synchronous motor (PMLSM) with segmented stator is applied in the long-distance auto-transportation system. For the PMLSM with the discontinuous stators, the mismatch between the permanent magnet (PM) mover and the stator would make electromagnetic (EM) parameters deflect nominal values, and then position/speed precision of the PM mover would be affected. In this article, the sensorless control based on the parameter calibration is used to drive the PM mover above the segmented stators during the drive process. Furthermore, an improved model reference adaptive integrator based on the parameter calibration is proposed to calibrate the EM parameters during the switch process. The simulation and experimental results confirm that the speed precision and the robustness of the segmented PMLSM are enhanced distinctly.