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1. Additional file 3 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 3: Figure S2. Validation of the rat anti-DUX4c serum.

Published
2023
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2. Additional file 10 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 10: Figure S9. DUX4c co-detection with MYOD or CD56 as myogenic cell markers, and CD56 immunodetection pattern in FSHD muscle sections.

Published
2023
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3. Additional file 7 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 7: Figure S6. DUX4c and laminin-α2 detection by co-immunofluorescence in FSHD muscle sections.

Published
2023
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4. Additional file 2 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 2: Figure S1. DUX4C mRNAs and protein in muscle cells.

Published
2023
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5. Additional file 1 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 1. DUX4c protein detection in testis. DUX4c partial co-localization with ILF3/NF90 in testis.

Published
2023
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6. Additional file 8 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 8: Figure S7. DUX4c-desmin co-detection by immunofluorescence in FSHD muscles.

Published
2023
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7. Additional file 17 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 17: Figure S16. DUX4c immunodetection and partial co-localization with the RNA-binding protein ILF3/NF90 in testis.

Published
2023
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8. Additional file 16 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 16: Figure S15. Partial co-localization of DUX4c with RNA binding proteins in differentiating muscle cells.

Published
2023
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9. Additional file 18 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 18: Figure S17. Myosin and macrophages detection in FSHD muscles.

Published
2023
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10. Additional file 13 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 13: Figure S12. C1qBP is the major DUX4c protein partner.

Published
2023
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11. Additional file 9 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 9: Figure S8. DUX4c is immunodetected in regenerating myofibers.

Published
2023
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12. Additional file 6 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 6: Figure S5. DUX4c detection by immunohistochemistry in muscle sections and histological alterations in FSHD muscles.

Published
2023
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13. Additional file 4 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 4: Figure S3. Time-course of DUX4c expression in primary FSHD muscle cells.

Published
2023
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14. Additional file 5 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 5: Figure S4. DUX4c immunofluorescence intensity variation during primary myoblast differentiation time-course.

Published
2023
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15. Additional file 15 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 15: Figure S14. Negative PLA controls in healthy and FSHD myofibers.

Published
2023
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16. Additional file 14 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 14: Figure S13. PLA experiments in myofibers (negative controls and detection of DUX4-C1qBP interactions).

Published
2023
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17. Additional file 11 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 11: Figure S10. DUX4c co-detection with Ki67 proliferation marker in DMD and FSHD muscles.

Published
2023
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18. Additional file 19 of The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Author

Claus, Clothilde, Slavin, Moriya, Ansseau, Eugénie, Lancelot, Céline, Bah, Karimatou, Lassche, Saskia, Fiévet, Manon, Greco, Anna, Tomaiuolo, Sara, Tassin, Alexandra, Dudome, Virginie, Kusters, Benno, Declèves, Anne-Emilie, Laoudj-Chenivesse, Dalila, van Engelen, Baziel G. M., Nonclercq, Denis, Belayew, Alexandra, Kalisman, Nir, and Coppée, Frédérique

Abstract

Additional file 19: Table S1. Primary antibodies. Table S2. Endogenous DUX4C mRNA sequences. Table S3. GTEx data on human DUX gene expression. Table S4. Clinical and histological features of patients and muscles, including patterns of DUX4c and DUX4 staining, their co-immunodetection with regeneration markers and their interaction with C1qBP (PLA).

Published
2023
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19. (Un)expected Similarity of the Temporary Adhesive Systems of Marine, Brackish, and Freshwater Flatworms

Author

Bertemes, Philip, Pjeta, Robert, Wunderer, Julia, Grosbusch, Alexandra L., Lengerer, Birgit, Grüner, Kevin, Knapp, Magdalena, Mertens, Birte, Andresen, Nikolas, Hess, Michael W., Tomaiuolo, Sara, Zankel, Armin, Holzer, Patrik, Salvenmoser, Willi, Egger, Bernhard, and Ladurner, Peter

Subjects
in situ hybridisation, Macrostomum, QH301-705.5, Animal Structures, Fresh Water, non-permanent adhesion, aquatic, Helminth Proteins, Article, Chemistry, RNA interference, duo-gland adhesive system, Biomimetic Materials, Platyhelminths, Adhesives, Animals, Seawater, Biology (General), glue, QD1-999
Abstract

Many free-living flatworms have evolved a temporary adhesion system, which allows them to quickly attach to and release from diverse substrates. In the marine Macrostomum lignano, the morphology of the adhesive system and the adhesion-related proteins have been characterised. However, little is known about how temporary adhesion is performed in other aquatic environments. Here, we performed a 3D reconstruction of the M. lignano adhesive organ and compared it to the morphology of five selected Macrostomum, representing two marine, one brackish, and two freshwater species. We compared the protein domains of the two adhesive proteins, as well as an anchor cell-specific intermediate filament. We analysed the gene expression of these proteins by in situ hybridisation and performed functional knockdowns with RNA interference. Remarkably, there are almost no differences in terms of morphology, protein regions, and gene expression based on marine, brackish, and freshwater habitats. This implies that glue components produced by macrostomids are conserved among species, and this set of two-component glue functions from low to high salinity. These findings could contribute to the development of novel reversible biomimetic glues that work in all wet environments and could have applications in drug delivery systems, tissue adhesives, or wound dressings.

Published
2021

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