1. Hopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis
- Author
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Sainz de la Maza, Susana, Maurino, Jorge, Castillo-Trivino, Tamara, Borges Guerra, Mónica, Sebastián Torres, Berta, Sotoca, Javier, Institut Català de la Salut, [Sainz de la Maza S] Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Maurino J] Medical Department, Roche Farma, Madrid, Spain. [Castillo-Triviño T] Department of Neurology, Hospital Universitario Donostia, San Sebastián, Spain. [Borges M] Department of Neurology, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Sebastián Torres B] Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Sotoca J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
conducta y mecanismos de la conducta::emociones::afecto [PSIQUIATRÍA Y PSICOLOGÍA] ,conducta y mecanismos de la conducta::conducta::síntomas conductuales::depresión [PSIQUIATRÍA Y PSICOLOGÍA] ,enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES] ,Behavior and Behavior Mechanisms::Emotions::Affect [PSYCHIATRY AND PSYCHOLOGY] ,Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES] ,Esclerosi múltiple ,disciplinas y actividades conductuales::pruebas psicológicas [PSIQUIATRÍA Y PSICOLOGÍA] ,Afecte (Psicologia) ,Behavioral Disciplines and Activities::Psychological Tests [PSYCHIATRY AND PSYCHOLOGY] ,Tests psicològics ,Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [PSYCHIATRY AND PSYCHOLOGY] - Abstract
Hopelessness; Relapsing-remitting multiple sclerosis; Suicide Desesperanza; Esclerosis múltiple recurrente-remitente; Suicidio Desesperança; Esclerosi múltiple recurrent-remitent; Suïcidi Background: Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. The aim of this study was to assess state hopelessness and its associated factors in early-stage RRMS. Methods: A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0– 5.5 were included. The State-Trait Hopelessness Scale (STHS) was used to measure patients´ hopelessness. A battery of patient-reported and clinician-rated measurements was used to assess clinical status. A multivariate logistic regression analysis was conducted to determine the association between patients’ characteristics and state hopelessness. Results: A total of 189 patients were included. Mean age (standard deviation-SD) was 36.1 (9.4) years and 71.4% were female. Median disease duration (interquartile range-IQR) was 1.4 (0.7, 2.1) years. Symptom severity and disability were low with a median EDSS (IQR) score of 1.0 (0, 2.0). A proportion of 65.6% (n=124) of patients reported moderate-to-severe hopelessness. Hopelessness was associated with older age (p=0.035), depressive symptoms (p=< 0.001), a threatening illness perception (p=0.001), and psychological and cognitive barriers to workplace performance (p=0.029) in the multivariate analysis after adjustment for confounders. Conclusion: Hopelessness was a common phenomenon in early-stage RRMS, even in a population with low physical disability. Identifying factors associated with hopelessness may be critical for implementing preventive strategies helping patients to adapt to the new situation and cope with the disease in the long term. This study was funded by Roche Medical Department, Spain (ML42064).
- Published
- 2023