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1. Relevance of cortisol and copeptin blood concentration changes in an experimental pain model

Author

Blum, Claudine, Velly, Laëtitia, Brochet, Christine, Ziegler, Frédéric, Tavolacci, Marie-Pierre, Hausfater, Pierre, Lvovschi, Virginie Eve, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Medical University Clinic, Kantonsspital Aarau, Tellstrasse 25, Haus 7, 5001, Aarau, Switzerland., BIOSFAST [CHU Pitié-Salpêtrière] (GRC 14), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Laboratoire de biochimie générale [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Services des urgences [CHU Rouen], and douville, sabine

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Abstract

International audience; Abstract The effect of pain and analgesics on stress biomarkers is not well studied. We evaluated the effect of acute pain and analgesics on serum cortisol and copeptin in an experimental pain model in healthy volunteers. Healthy volunteers presented at 8 a.m. for an experimental pain stimulation. Cortisol and copeptin levels were measured before, during and after electrophysiological stimulation, first before and then during opioid delivery. Difference in biomarker levels compared to baseline levels was calculated, and potential influencing factors were evaluated by linear regression analysis. Cortisol decreased by 13% during the 10 min of rest at baseline, but copeptin did not change significantly. Cortisol had a median decrease of −24% or −83 nmol/l (−44 to −124 nmol/l, p = 0.0002) during the electrophysiological stimulation training session, while the median difference for copeptin was −22% or −1.01 pmol/l (−2.35 to 0.08 pmol/l, p = 0.0003). After administration of opioids, cortisol did not decrease but increased by 3% (p = 0.043), indicating an increasing opioids effect on cortisol. This effect was not visible for copeptin (median change −0.003 pmol/l (−0.50 to 0.24), p = 0.45). In this experimental pain model performed in the morning, moderate pain did not have a relevant effect on cortisol or copeptin levels, whereas opioids led to a discrete peak of cortisol. Clinicaltrials.gov identifier: NCT01975753 (registered on November 5, 2013, before start of recruitment).

Published
2022

2. COVID-19 Vaccine Acceptance, Hesitancy, and Resistancy among University Students in France

Author

Tavolacci, Marie Pierre, Dechelotte, Pierre, Ladner, Joel, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Département d'épidémiologie et de promotion de la santé [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen], and douville, sabine

Subjects
vaccine resistancy, university student, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], education, vaccine acceptance, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], COVID-19, vaccine hesistancy, Medicine, Article
Abstract

International audience; The objectives were to explore, among university students, the level of COVID-19 vaccine acceptance, hesitancy, and resistancy and to determine the motivations and barriers, and the reasons that may change student vaccination decision making. An online observational cross-sectional study was conducted among students of a French university in January 2021 with questions about the intention to be vaccinated against COVID-19, the motivations and the barriers. The convenience sample included 3089 students, with a mean of age of 20.3 (SD = 1.9). To the question on the intention to vaccinate against the COVID-19, 58.0% of students reported that they would choose to have a vaccination, 17.0% reported that they would not and 25.0% were not sure. The main motivations for vaccine acceptance were “I don′t want to transmit COVID-19 to others”, the main barriers for vaccine resistance or hesitancy were “I prefer to wait until I have more experience with these new vaccines”. Age, female gender, being in first three years of study, studied sciences courses and neither sciences nor healthcare courses of study were significantly associated with a higher risk of vaccine hesitancy or resistancy. Self-estimated knowledge of conventional vaccines and COVID-19 vaccines, and confidence in efficiency and safety of conventional vaccination were associated with a lower risk of vaccine hesitancy or resistancy. It is relevant to disseminate evidence-based interventions to promote COVID-19 vaccine acceptability for college students, especially for the students in neither sciences nor healthcare courses of study, as college students will soon be eligible to receive a COVID-19 vaccine.

Published
2021

3. Screening four broad categories of eating disorders: suitability of a clinical algorithm adapted from the SCOFF questionnaire

Author

Tavolacci, Marie-Pierre, Gillibert, André, Zhu Soubise, Aurélien, Grigioni, Sébastien, Déchelotte, Pierre, Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and Normandie Université (NU)

Subjects
Adult, Male, Adolescent, lcsh:RC435-571, SCOFF questionnaire, Middle Aged, Body Mass Index, Diagnostic and Statistical Manual of Mental Disorders, Feeding and Eating Disorders, Algorithm, Young Adult, Surveys and Questionnaires, lcsh:Psychiatry, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Screening, Eating disorders, Humans, Mass Screening, Female, General practice, Algorithms, ComputingMilieux_MISCELLANEOUS, Research Article
Abstract

Background We evaluated the performance of a clinical algorithm (Expali™), combining two or more positive answers to SCOFF questionnaire with Body Mass Index (BMI), to identify four Broad Categories of eating disorders (ED) derived from DSM-5. Methods The clinical algorithm (Expali™) was developed from 104 combinations of BMI levels and answers to five SCOFF questions with at least two positive answers. Two senior ED physicians allocated each combination to one of the four Broad Categories of ED derived from DSM-5: restrictive disorder, bulimic disorder, hyperphagic disorder and other unspecified ED diagnosed by ED clinicians. The performance of Expali™ was evaluated on data from 206 patients with ED. Sensitivity, specificity values and Youden index were calculated for each category. Results The 206 patients were diagnosed as follows: 31.5% restrictive disorder, 18.9% bulimic disorder, 40.8% hyperphagic disorder and 8.8% other ED. The sensitivity of Expali™ for restrictive, bulimic, hyperphagic and other unspecified ED were respectively: 76.9, 69.2, 79.7 and 16.7%. The Youden index was respectively 0.73, 0.57, 0.67 and 0.07. Conclusions In a SCOFF-positive ED population (at least two positive answers), the clinical algorithm Expali™ demonstrated good suitability by correctly classifying three of the four Broad Categories of eating disorders (restrictive, bulimic and hyperphagic disorder). It could be useful both to healthcare professionals and the general population to enable earlier detection and treatment of ED and to improve patient outcomes.

Published
2019

4. Identification and characterization of human observational studies in nutritional epidemiology on gut microbiomics for joint data analysis

Author

Pinart, Mariona, Nimptsch, Katharina, Forslund, Sofia, Schlicht, Kristina, Gueimonde, Miguel, Brigidi, Patrizia, Turroni, Silvia, Ahrens, Wolfgang, Hebestreit, Antje, Wolters, Maike, Dötsch, Andreas, Nöthlings, Ute, Oluwagbemigun, Kolade, Cuadrat, Rafael, Schulze, Matthias, Standl, Marie, Schloter, Michael, De Angelis, Maria, Iozzo, Patricia, Guzzardi, Maria Angela, Vlaemynck, Geertrui, Penders, John, Jonkers, Daisy, Stemmer, Maya, Chiesa, Giulia, Cavalieri, Duccio, De Filippo, Carlotta, Ercolini, Danilo, De Filippis, Francesca, Ribet, David, Achamrah, Najate, Tavolacci, Marie-Pierre, Déchelotte, Pierre, Bouwman, Jildau, Laudes, Matthias, Pischon, Tobias, Pinart M., Nimptsch K., Forslund S.K., Schlicht K., Gueimonde M., Brigidi P., Turroni S., Ahrens W., Hebestreit A., Wolters M., Dotsch A., Nothlings U., Oluwagbemigun K., Cuadrat R.R.C., Schulze M.B., Standl M., Schloter M., De Angelis M., Iozzo P., Guzzardi M.A., Vlaemynck G., Penders J., Jonkers D.M.A.E., Stemmer M., Chiesa G., Cavalieri D., De Filippo C., Ercolini D., De Filippis F., Ribet D., Achamrah N., Tavolacci M.-P., Dechelotte P., Bouwman J., Laudes M., Pischon T., Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany, Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany, Host-Microbiome Factors in Cardiovascular Disease Lab, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany, German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, 10785 Berlin, Germany, Berlin Institute of Health (BIH), 10178 Berlin, Germany, Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany, Institute of Diabetes and Clinical Metabolic Research, University of Kiel, 24105 Kiel, Germany, Department of Microbiology and Biochemistry of Dairy Products, IPLA-CSIC, 33300 Villaviciosa, Spain, Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain, Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy, Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359 Bremen, Germany, Institute of Statistics, Bremen University, 28359 Bremen, Germany, Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut (MRI)-Federal Research Institute of Nutrition and Food, 76131 Karlsruhe, Germany, Nutritional Epidemiology Unit, Institute of Nutrition and Food Sciences, University of Bonn, 53115 Bonn, Germany, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany, Institute of Nutritional Science, University of Potsdam, 14558 Potsdam, Germany, German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany, Research Unit for Comparative Microbiome Analysis, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany, Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, Italy, Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy, Department Technology and Food, Flanders Research Institute for Agriculture, Fisheries and Food, 9090 Melle, Belgium, Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM) and Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands, Department of Internal Medicine, Division Gastroenterology-Hepatology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands, Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Beer-Sheva P.O. Box 653, Israel, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Florence, Italy, Institute of Agricultural Biology and Biotechnology National Research Council, Via Moruzzi 1, 56124 Pisa, Italy, Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy, Task Force on Microbiome Studies, University of Naples Federico II, 80134 Naples, Italy, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microbiology and Systems Biology Group, TNO, Utrechtseweg 48, 3704 HE Zeist, The Netherlands, Biobank Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany, Biobank Core Facility, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10178 Berlin, Germany, European Commission, Fonds de la Recherche Scientifique (Fédération Wallonie-Bruxelles), Research Foundation - Flanders, Institut National de la Santé et de la Recherche Médicale (France), Federal Ministry of Education and Research (Germany), Federal Ministry of Food and Agriculture (Germany), Ministero dell'Istruzione, dell'Università e della Ricerca, Ministero delle Politiche Agricole Alimentari e Forestali, National Institutes of Health (US), Ministero della Salute, Instituto de Salud Carlos III, Netherlands Organisation for Health Research and Development, Austrian Research Promotion Agency, Federal Ministry of Education, Science and Research (Austria), Ministry of Science, Technology and Space (Israel), Swedish Research Council for Sustainable Development, German Research Foundation, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Med Microbiol, Infect Dis & Infect Prev, RS: NUTRIM - R2 - Liver and digestive health, Interne Geneeskunde, Pinart, M., Nimptsch, K., Forslund, S. K., Schlicht, K., Gueimonde, M., Brigidi, P., Turroni, S., Ahrens, W., Hebestreit, A., Wolters, M., Dotsch, A., Nothlings, U., Oluwagbemigun, K., Cuadrat, R. R. C., Schulze, M. B., Standl, M., Schloter, M., De Angelis, M., Iozzo, P., Guzzardi, M. A., Vlaemynck, G., Penders, J., Jonkers, D. M. A. E., Stemmer, M., Chiesa, G., Cavalieri, D., De Filippo, C., Ercolini, D., De Filippis, F., Ribet, D., Achamrah, N., Tavolacci, M. -P., Dechelotte, P., Bouwman, J., Laudes, M., Pischon, T., Humboldt-Universität zu Berlin, and CHU Rouen

Subjects
Nutritional Sciences, Metabolome, Metadata, Data sharing, Observational studies, Data integration, Dietary intake, Microbiome, Diet Surveys, Article, Eating, Nutritional Science, AGE, Humans, TX341-641, observational studies, Nutrition. Foods and food supply, Information Dissemination, Nutrition Survey, Nutrition Surveys, Observational studie, Gastrointestinal Microbiome, Diet Survey, Europe, Observational Studies as Topic, Cardiovascular and Metabolic Diseases, Data Integration, Data Sharing, Dietary Intake, Observational Studies, Technology Platforms, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Human
Abstract

In any research field, data access and data integration are major challenges that even large, well-established consortia face. Although data sharing initiatives are increasing, joint data analyses on nutrition and microbiomics in health and disease are still scarce. We aimed to identify observational studies with data on nutrition and gut microbiome composition from the Intestinal Microbiomics (INTIMIC) Knowledge Platform following the findable, accessible, interoperable, and reusable (FAIR) principles. An adapted template from the European Nutritional Phenotype Assessment and Data Sharing Initiative (ENPADASI) consortium was used to collect microbiome-specific information and other related factors. In total, 23 studies (17 longitudinal and 6 cross-sectional) were identified from Italy (7), Germany (6), Netherlands (3), Spain (2), Belgium (1), and France (1) or multiple countries (3). Of these, 21 studies collected information on both dietary intake (24 h dietary recall, food frequency questionnaire (FFQ), or Food Records) and gut microbiome. All studies collected stool samples. The most often used sequencing platform was Illumina MiSeq, and the preferred hypervariable regions of the 16S rRNA gene were V3–V4 or V4. The combination of datasets will allow for sufficiently powered investigations to increase the knowledge and understanding of the relationship between food and gut microbiome in health and disease., This research was supported by the Joint Action “European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)”and the respective national/regional funding organisations: Fund for Scientific Research (FRS—FNRS, Belgium); Research Foundation—Flanders (FWO, Belgium); INSERM Institut National de la Santé et de la Recherche Médicale (France); Federal Ministry of Education and Research (BMBF, FKZ 01EA1906B, 01EA1906D); Federal Ministry of Food and Agriculture (BMEL) through the Federal Office for Agriculture and Food (BLE, Germany, grant number 2819ERA10F); Ministry of Education, University and Research (MIUR), Ministry of agricultural, food and forestry policies (MiPAAF), National Institute of Health (ISS) on behalf of Ministry of Health (Italy); National Institute of Health Carlos III (Spain); The Netherlands Organisation for Health Research and Development (ZonMw, The Netherlands), Austrian Research Promotion Agency (FFG) on behalf of the Austrian Federal Ministry for Education, Science and Research (BMBWF), Ministry of Science and Technology (Israel), Formas (Sweden). This research was also supported by the German Research Foundation (DFG, KFO339: “food@”).

Published
2021

6. Anxiety and Depression Profile Is Associated With Eating Disorders in Patients With Irritable Bowel Syndrome

Author

Melchior, Chloé, Desprez, Charlotte, Riachi, Ghassan, Leroi, Anne-Marie, Déchelotte, Pierre, Achamrah, Najate, Ducrotté, Philippe, Tavolacci, Marie-Pierre, Gourcerol, Guillaume, Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], CHU Rouen, Normandie Université (NU)-Hôpital Charles Nicolle [Rouen], Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], and Normandie Université (NU)-Normandie Université (NU)-CHU Rouen

Subjects
Psychiatry, healthy volunteers, quality of life, stressful life events, Rome III criteria, body mass index (BMI), validated self-questionnaires, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS, Original Research
Abstract

Objective: To compare the prevalence of anxiety and depression states and eating disorders (EDs) between patients with irritable bowel syndrome (IBS) and healthy volunteers without IBS. Methods: IBS patients according to Rome III criteria referred to our tertiary care center for therapeutic management and matched volunteers without IBS were prospectively included. EDs were screened by Sick, Control, One stone, Fat, Food—French version (SCOFF-F) questionnaire. IBS symptom severity (IBS symptom severity score), stool consistency (Bristol stool scale), anxiety and depression levels (Hospital Anxiety and Depression scale), and quality of life (validated Gastrointestinal Quality of Life Index) were assessed by validated self-questionnaires. Results: IBS (228) patients and healthy volunteers (228) were included. Mean age was 42.5 ± 13.9 years with mainly women (76.7%). Among IBS patients, 25.4% had positive SCOFF-F compared to 21.1% of volunteers. IBS patients more frequently had a lower body mass index (BMI) than volunteers (p < 0.0001). IBS patients with ED had poorer quality of life and more stressful life events (p = 0.02) than IBS patients without ED. The prevalence of anxiety and depression was significantly higher in IBS patients with ED than in volunteers without ED, respectively (19.0% vs 1.9%, p=0.00, and 60.3% vs 19.7%, p < 0.0001). Conclusions: The prevalence of ED assessed with positive SCOFF-F questionnaire was not significantly different between IBS patients and healthy volunteers. The combination of IBS and ED was associated with higher levels of anxiety or depression and poorer quality of life.

Published
2019

7. Does binge drinking between the age of 18 and 25 years predict alcohol dependence in adulthood? A retrospective case–control study in France

Author

Tavolacci, Marie-Pierre, Berthon, Quentin, Cerasuolo, Damiano, Dechelotte, Pierre, Ladner, Joel, Baguet, Alexandre, Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Départment Addictologie, CHU Rouen, France, Service de nutrition [CHU Rouen], CHU Rouen, Normandie Université (NU), Département d'épidémiologie et de promotion de la santé [Rouen], and Département Addictologie, CHU Rouen, France

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Objective A retrospective case–control study wasconducted to evaluate whether frequent binge drinkingbetween the age of 18 and 25 years was a risk factor foralcohol dependence in adulthood.Setting The Department of Addictive Medicine and theClinical Investigation Center of a university hospital inFrance.Participants Cases were alcohol-dependentpatients between 25 and 45 years and diagnosedby a psychiatrist. Consecutive patients referred tothe Department of Addictive Medicine of a universityhospital between 1 January 2017 and 31 December2017 for alcohol dependence were included in the study.Controls were non-alcohol-dependent adults, definedaccording to an Alcohol Use Disorders Identification Testscore of less than 8, and were matched on age and sexwith cases. Data on sociodemographics, behaviour andalcohol consumption were retrospectively collected forthree life periods: before the age of 18 years; betweenthe age of 18 and 25 years; and between the age of 25and 45 years. Frequency of binge drinking between 18and 25 years was categorised as frequent if more thantwice a month, occasional if once a month and never ifno binge drinking.Results 166 adults between 25 and 45 years wereincluded: 83 were alcohol-dependent and 83 werenon-alcohol-dependent. The mean age was 34.6 years(SD: 5.1). Frequent binge drinking between 18 and 25years occurred in 75.9% of cases and 41.0% of controls(p

Published
2019

8. Additional file 2: of Nebulized versus intravenous morphine titration for the initial treatment of severe acute pain in the emergency department: study protocol for a multicenter, prospective randomized and controlled trial, CLIN-AEROMORPH

Author

Lvovschi, Virginie, Joly, Justine, Lemaire, Nicolas, Maignan, Maxime, Canavaggio, Pauline, Leroi, Anne-Marie, Tavolacci, Marie-Pierre, and Luc-Marie Joly

Abstract

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist. (DOC 132 kb)

Published
2019
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10. Attention-deficit hyperactivity disorder and addictions (substance and behavioral): Prevalence and characteristics in a multicenter study in France

Author

Romo, Lucia, Ladner, Joel, Kotbagi, Gayatri, Morvan, Yannick, Saleh, Dalia, Tavolacci, Marie Pierre, Kern, Laurence, Clinique, Psychanalyse, Développement (CliPsyD), Université Paris Nanterre (UPN), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Département d'épidémiologie et de promotion de la santé [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Counseling Psychology, Tishreen University , Latakia, Syria., Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche sur le Sport et le Mouvement (CeRSM), douville, sabine, Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hôpital Charles Nicolle [Rouen]-CHU Rouen

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

11. Les caractéristiques des étudiants participants à la première étude sur le style de vie et le comportement, fait à Cluj, Roumanie

Author

Brumboiu, Maria Irina, Mougin, Sarah, Cazacu, Irina, Mogosan, Cristina Ionela, Porrovecchio, Alessandro, Ladner, Joel, Tavolacci, Marie-Pierre, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, and Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO)

Subjects
lifestyle, behaviors, education, students, [SHS]Humanities and Social Sciences
Abstract

International audience; In this article we describe the demographic and socio-economic characteristics of the students participating in the first study assessing the lifestyle and behaviors that was carried out in Cluj, Romania. Participants in the study were predominantly female, facing financial difficulties, having nutritional disorders in deficit rather than in excess and expressing interest in preventive medicine services

Published
2016

12. Activité physique chez les étudiants : prévalence et profils de comportements à risque associés

Author

Ladner, Joel, Porrovecchio, Alessandro, Masson, Philippe, Zunquin, Gauthier, Hurdiel, Rémy, Pezé, Thierry, Theunynck, Denis, Tavolacci, Marie-Pierre, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Equipe de Recherche Septentrionale ' Sport et Société' - EA4110 (ER3S), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Droit et Santé, Laboratoire Recherche Littorale en Activités Corporelles et Sportives (RELACS), Université du Littoral Côte d'Opale (ULCO), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), Université de Lille, Droit et Santé-Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369 (URePSSS), Equipe de Recherche Septentrionale ' Sport et Société ' (ER3S), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-PRES Université Lille Nord de France-Université de Lille, Droit et Santé, Laboratoire Recherche Littoral en Activités Corporelles et Sportives, Centre d'Investigation Clinique [Rouen] (CIC Rouen), and Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Rouen

Subjects
Adult, Male, Adolescent, Alcohol Drinking, Feeding and Eating Disorders, Young Adult, Risk-Taking, MESH: Cross-Sectional Studies, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Prevalence, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Students, Exercise, MESH: Prevalence, MESH: Adolescent, MESH: Humans, MESH: Adult, MESH: Male, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Cross-Sectional Studies, MESH: Risk-Taking, MESH: Feeding and Eating Disorders, MESH: Young Adult, MESH: Exercise, MESH: Students, Female, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH: Alcohol Drinking
Abstract

International audience; More than 40% of students do not practice any PA. These results highlight the need for a better understanding to develop intervention strategies for students, based on new public health approaches. The contribution of social and physical environmental factors to changes in PA needs to be further explored. .

Published
2016

15. Strategy for recruitment and factors associated with motivation and satisfaction in a randomized trial with 210 healthy volunteers without financial compensation

Author

Luzurier, Quentin, Damm, Cédric, Lion, Fabien, Daniel, Carine, Pellerin, Lucille, Tavolacci, Marie-Pierre, Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de soins intensifs [CHU Rouen], CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), and Normandie Université (NU)-Normandie Université (NU)

Subjects
Adult, Male, Motivation, Biomedical Research, Adolescent, Epidemiology, Patient Selection, Satisfaction, Heart Massage, Personal Satisfaction, Middle Aged, Healthy Volunteers, Telephone, Young Adult, Research Design, Interventional study, Surveys and Questionnaires, Humans, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Recruitment, ComputingMilieux_MISCELLANEOUS, Research Article, Randomized Controlled Trials as Topic
Abstract

Background The aim was to describe a strategy for recruitment of healthy volunteers (HV) to a randomized trial that assessed the efficacy of different telephone techniques to assist HV in performing cardiac massage for vital emergency. Participation in the randomized trial was not financially compensated, however HV were offered emergency first-aid training. We also studied factors associated with HV motivation and satisfaction regarding participation in the trial. Methods Strategy for recruitment of 210 HV aged 18 to 60 years was based on: (1) the updated records of all telephone number since January 2000 of HV registered in the Rouen Clinical Investigation Centre HV database, (2) a communication campaign for the general public focussing on posters and media advertisements. Data on the recruitment, socio-demographics, motivation and satisfaction of the 210 HV were collected by anonymous self-administered questionnaire. Results Of the 210 HV included, 63.3% (n = 133) were recruited from the HV database and 36.7% (n = 77) by the communication campaign. On the one hand, the HV database enabled screening of 1315 HV, 54.8% (n = 721) of whom were reached by phone, 55.2% (n = 398) of these latter accepted to participate in the study and 10.1% of the initial screening (n = 133) were finally included. One the other hand, for the 77 HV not recruited from the HV database, word-of-mouth (56.1%) was the main means of recruitment. The male/female ratio of the 210 HV was 0.5 and mean age 43.5 years (Standard Deviation = 12.4). The main motivations given for participating in the trial were to support research (87.6%) and receive emergency first-aid training (85.7%). Overall satisfaction with the welcome process was significantly higher for older HV (46–60 years) (adjusted odds ratio (AOR): 3.44; 95% confidence interval (95% CI): 1.48-7.99), and for HV in management jobs (AOR: 4.26; 95% CI: 1.22-14.87). Satisfaction with protocol management was higher for women (AOR: 2.33; 95% CI: 1.18-4.60) and for older HV (46–60 years) (AOR: 4.76; 95% CI: 1.97-11.52). Conclusions Recruitment of non-compensated HV required broad screening with a primary HV database alongside word-of-mouth communication which seemed more efficient than media advertising. To enhance HV recruitment to randomized trials without financial compensation it seems crucial to provide them not only with a direct interest but also to ensure their satisfaction.

Published
2015

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