1. The Risk of Recurrence in Endometrial Cancer Patients with Low-Volume Metastasis in the Sentinel Lymph Nodes: A Retrospective Multi-Institutional Study
- Author
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Buda, Alessandro, Paniga, Cristiana, Taskin, Salih, Mueller, Michael, Zapardiel, Ignacio, Fanfani, Francesco, Puppo, Andrea, Casarin, Jvan, Papadia, Andrea, De Ponti, Elena, Grassi, Tommaso, Mauro, Jessica, Turan, Hasan, Vatansever, Dogan, Gungor, Mete, Ortag, Firat, Imboden, Sara, Garcia-Pineda, Virginia, Mohr, Stefan, Siegenthaler, Franziska, Perotto, Stefania, Landoni, Fabio, Ghezzi, Fabio, Scambia, Giovanni, Taskiran, Cagatay, Fruscio, Robert, Buda, A, Paniga, C, Taskin, S, Mueller, M, Zapardiel, I, Fanfani, F, Puppo, A, Casarin, J, Papadia, A, De Ponti, E, Grassi, T, Mauro, J, Turan, H, Vatansever, D, Gungor, M, Ortag, F, Imboden, S, Garcia-Pineda, V, Mohr, S, Siegenthaler, F, Perotto, S, Landoni, F, Ghezzi, F, Scambia, G, Taskiran, C, and Fruscio, R
- Subjects
endometrial cancer ,low-volume metastasis ,sentinel lymph node biopsy ,ultrastaging ,recurrence-free survival ,Cancer Research ,Oncology ,low-volume metastasi ,610 Medicine & health - Abstract
The aim of this study was to assess the impact of low-volume metastasis (LVM) on disease-free survival (DFS) in women with apparent early-stage endometrial cancer (EC) who underwent sentinel lymph node (SLN) mapping. Patients with pre-operative early-stage EC were retrospectively collected from an international collaboration including 13 referring institutions. A total of 1428 patients were included in this analysis. One hundred and eighty-six patients (13%) had lymph node involvement. Fifty-nine percent of positive SLN exhibited micrometastases, 26.9% micrometastases, and 14% isolated tumor cells. Seventeen patients with positive lymph nodes did not receive any adjuvant therapy. At a median follow-up of 33.3 months, the disease had recurred in 114 women (8%). Patients with micrometastases in the lymph nodes had a worse prognosis of disease-free survival compared to patients with negative nodes or LVM. The rate of recurrence was significantly higher for women with micrometastases than those with low-volume metastases (HR = 2.61; p = 0.01). The administration of adjuvant treatment in patients with LVM, without uterine risk factors, remains a matter of debate and requires further evaluation.
- Published
- 2023
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