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3. Raccomandazioni cliniche per i principali tumori solidi

Author

Allegrini, G., Amoroso, D., Angioli, D., Arcangeli, Annarosa, Bechi, Paolo, Biti, G., Calvaruso, V., Celona, G., Di Giorgi, U., Di Lieto, M., Fabbrucci, P., Fiorentini, G., Franceschini, F., Fucini, Claudio, Galardi, A., Gasperoni, S., Genuardi, M., Goletti, O., Grazzini, G., Janni, A., Lazzi, S., Manetti, A., Mantellini, P., Masi, A., Mazza, E., Medi, F., Messerini, L., Mignogna, M., Mini, E., Moretti, R., Morettini, A., Mosca, F., Naspetti, R., Paci, E. £., Pinto, E., Ponticelli, P., Pirtoli, L., Piliti, M., Ribecco, A. S., Sainato, A., Sarnelli, R., Seccia, M., Tagliagambe, A., Tanzini, G., Tonelli, F., Valanzano, R., Valeri, A., and Venturini, G.

Subjects
raccomandazioni cliniche, tumori solidi
Published
2005

11. [Family anamnesis, cholecystectomy and gastric resection in patients with colorectal carcinoma: a case-control study]

Author

Civitelli, Serenella, Civitelli, B, Landini, T, Pacchiarotti, Mc, Mancini, A, and Tanzini, G.

Subjects
Adult, Aged, 80 and over, Male, Time Factors, Colonoscopy, Middle Aged, Gastrectomy, Risk Factors, Data Interpretation, Statistical, Humans, Cholecystectomy, Female, Colorectal Neoplasms, Aged
Abstract

An increased risk of colorectal cancer has been reported in first-degree relatives of affected patients, and following cholecystectomy or partial gastrectomy for benign peptic ulcer disease. The aim of this study was to examine the incidence of these potential risk factors in 197 patients (127 males, 70 females, mean age 70 years +/- 10.9, range 22-94 years) with cancer of the large bowel and 202 controls (91 males, 111 females, mean age 68 years +/- 14.06, range 17-93 years) who underwent a total colonoscopy, that revealed no colorectal neoplasms. No significant differences were found between the case and control group for a past history of cholecystectomy or gastric surgery, respectively reported by 14 and 12 patients of group 1 and 18 and 8 patients of group 2. Patients with large bowel cancer show a significant excess of both colorectal (21.31% vs 11.9%) and extracolonic malignancies (46.19% vs 26.73) in first degree relatives (p0.05). In approximately 7% of them the aggregation of two or more colorectal cancers among relatives is suggestive for a hereditary form of large bowel cancer.

Published
1996

16. Petrioli R, Lorenzi M, Aquino A, Marsili S, Frediani B, Palazzuoli V, Marzocca G, Botta G,Tani F, De Martino A, Testi W, Setacci C, Salvestrini F, DeSando D, Bovenga S, Mariani L,Mancini S, Tanzini G, Armenio S, Marinello E, Francini G

Author

Petrioli, R, Lorenzi, M, Aquino, A, Marsili, S, Frediani, Bruno, Palazzuoli, V, Marzocca, G, Botta, Giuseppe, Tani, F, De Martino, A, Testi, W, Setacci, Carlo, Salvestrini, F, Desando, D, Bovenga, S, Mariani, L, Mancini, S, Tanzini, G, Armenio, S, Marinello, E, and Francini, Guido

Published
1995

18. [Update on epidemiology and risk factors of colorectal carcinoma]

Author

Civitelli, Serenella, Civitelli, B, Pacchiarotti, Mc, and Tanzini, G.

Subjects
Adult, Causality, Male, Sex Factors, Italy, Risk Factors, Age Factors, Humans, Female, Middle Aged, Colorectal Neoplasms, Precancerous Conditions, Aged
Abstract

Etiology of colorectal cancer is not completely clear. Epidemiologic studies, especially those on migrant populations, demonstrate the importance of environmental factors, particularly dietary, in cancerogenesis. Anyway, familial aggregation within a given population shows that genetic factors play an important role. General risk factors are represented by age, sex, physical activity... while some pathologies increased the risk of developing KCR or are frankly precancerous (adenomas, ulcerative colitis, Crohn's disease...).

Published
1995

20. [Blood gastrin and colorectal neoplasms]

Author

Civitelli, Serenella, Galgani, P, Pacchiarotti, Mc, Civitelli, B, Marini, M, Pedani, M, Bernini, A, and Tanzini, G.

Subjects
Adenoma, Adult, Aged, 80 and over, Male, Carcinoma, Gastrins, Radioimmunoassay, Humans, Female, Middle Aged, Colorectal Neoplasms, Aged
Abstract

Gastrin has a trophic effect on the mucosa of the gastrointestinal tract and seems to have the potential for promoting colonic cancerogenesis through a chronic stimulation of the epithelial proliferation. Plasma gastrin has been reported to be elevated in patients with colorectal neoplasms. The aim of the present study was to verify this observation. Presurgical serum levels of gastrin were compared between 49 patients with colorectal neoplasms and 47 controls hospitalized for other surgical lesions. Results show significantly higher gastrin levels of case group than controls: 72.72 + 85.41 vs. 46.79 + 24.09 pg/ml (p0.05), and provide support for the hypothesis of a gastrin-stimulated neoplastic growth enhancing at the same time the potential therapeutic role of reducing gastrin secretion.

Published
1994

26. Fast and convenient access to fluid dynamics data via the world wide Web

Author

Vucinic, D., Favaro, J., Sünder, B., Jenkinson, I., Tanzini, G., Hazarika, B. K., D Alcalà, M. R., Vicinanza, D., Roberto Greco, Pasanisi, A., Spanish Association for Numerical Methods in Engineering, Barcelona, Spain, Vucinic, D., Favaro, J., Sunder, B., Jenkinson, I., Tanzini, G., Hazarika, B., RIBERA D’ALCALÀ, M., Vicinanza, Diego, Greco, Roberto, and Pasanisi, A.

29. Folinic acid, 5-fluorouracil and etoposide after curative resection for gastric cancer

Author

Petrioli, R., Sabatino, M., Roviello, F., DANIELE MARRELLI, Nastri, G., Marsili, S., Correale, P., Pozzessere, D., Messinese, S., Martino, A., Tani, F., Marzocca, G., Lorenzi, M., Civitelli, S., Tanzini, G., Pinto, E., and Francini, G.

Subjects
Male, Levoleucovorin, gastric cancer, Leucovorin, Middle Aged, etoposide, adjuvant chemotherapy, Chemotherapy, Adjuvant, Gastrectomy, Stomach Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, 5-fluorouracil, Fluorouracil
Abstract

The aim of this study was to evaluate the survival benefit of adjuvant chemotherapy with etoposide, leucovorin and 5-fluorouracil (ELF) in gastric cancer patients undergoing previous surgery with a curative intent.The clinical outcome of 49 patients with resected gastric cancer treated with adjuvant chemotherapy was compared with that of 85 surgically treated historical controls who did not receive any adjuvant treatment. The chemotherapy regimen consisted of six cycles of daily 1-hour intravenous infusions of folinic acid 100 mg/m2 and 5-FU 400 mg/ m2, and a 2-hour infusion of etoposide 100 mg/m2, for three days every 28 days.The 5-year relapse-free survival was 32% in the adjuvant arm and 27% in the control arm (p = 0.6). At the last follow-up, there were 32 deaths in the adjuvant arm and 60 in the control arm. The median duration of survival was respectively 23 and 19 months, and the 5-year survival rates were 34% and 29% (p = 0.4). The chemotherapy was well tolerated.Our data suggest that ELF adjuvant treatment is a safe and well tolerable combination chemotherapy in patients with resected gastric cancer, but it does not seem to improve prognosis in comparison with historical controls.

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