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This study investigated the effect of using the Internet on depression symptoms of older Chinese, based on 7,801 adults aged over 60 years from the 2018 China Family Panel Studies. Results showed that the elderly who used the Internet reported lower depression scores, and the more frequent they use Internet, the lower their depression scores. Moreover, using the Internet for social contact and entertainment decreased the depression scores of the older adults, but when using Internet for learn, work, and commercial activity, the relief of depressive symptoms disappeared. Therelief of depression symptoms through Internet use were heterogeneous among different groups: the elderly aged 60–70, women, rural residents, and those with lower education attainment. Moreover, Internet use decreased the depression scores by increasing the frequency of contact with their children and increasing the importance of their enjoyment of life. According to the relief of depression by using Internet reasonably, policies should be designed to ensure that all ages could have easy access to the Internet.

Supplementary_Tables for Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population by Fei-Yu Chen, Hao Wang, Hui Li, Xue-Li Hu, Xu Dai, Shou-Man Wang, Guo-Jiao Yan, Ping-Lan Jiang, Yuan-Ping Hu, Juan Huang, and Li-Li Tang in Technology in Cancer Research & Treatment

Background: Anorectal malformations (ARMs) represent a variety of congenital disorders that involve abnormal termination of the anorectum. This study was to reveal relation between CDX1 and human ARMs phenotypes.Methods: 108 Chinese patients and 120 Chinese controls were included in this study. We analyzed the relation between two by PCR, qRT-PCR, western blot and immunofluorescence.Results: Four heterozygous mutations in CDX1 gene were identified in ARMs patients (3.7%, 4/108), no found in controls. CDX1 protein expression was significantly decreased in the ARMs compared with the control anorectum. All samples analyzed in ARMs group exhibited down-regulated CDX1 mRNA expression in comparison to matched normal group, demonstrated significant differences statistically.Conclusion: The findings represented the relation between CDX1 mutations and CDX1 genotype. Furthermore, it was suggested that the downregulation of CDX1 might be related to the development of ARMs.