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38 results on '"Tabilio, Antonio"'

13. Diagnostic considerations about visceral leishmaniasis. Two case report

Author

Pasticci, Maria Bruna, Papili, Rita, Menichetti, Francesco, Ballanti, Stelvio, Ottaviani, Letizia, Tabilio, Antonio, and Stagni, Giuliano

Subjects
Adult, Biopsy, Antiprotozoal Agents, Antibodies, Protozoan, Sensitivity and Specificity, Antibodies, Diagnosis, Differential, Bone Marrow, Amphotericin B, Diagnosis, Animals, False Negative Reactions, Female, Humans, Immunocompetence, Leishmania, Leishmaniasis, Visceral, Liver, Middle Aged, Spleen, Splenectomy, Leishmaniasis, Visceral, Protozoan, Differential
Abstract

Two cases of visceral leishmaniasis (VL) in immunocompetent patients have been described. Both patients lived in endemicic areas for leishmaniasis in the south of Italy, tested positive for anti-Leishmania antibodies. A definitive diagnosis of VL was delayed by false negative microscopic examinations. Both patients were treated successfully with liposomal amphotericin B.Immuno Fluorescent Assay (IFA) performed as an available test. It helped to pursue the correct diagnosis and therapy. Microscopy is reported to be highly sensitive and specific in the diagnosis of VL, nevertheless it may yield false negative results when examined in laboratories without good expertness.

Published
2003

14. Decreased bone mineral density after autologous stem cell transplantation

Author

Ria, R., Scarponi, A., Falzetti, F., Ballanti, S., Di Ianni, M., Cimminiello, M., Gasbarrino, C., Pallone, B., Russo, F., Cirulli, T., Vacca, A., Dammanco, F., Mannarino, Elmo, Martelli, Massimo Fabrizio, and Tabilio, Antonio

Subjects
cellule staminali, trapianto autologo, minerale osseo
Published
2003

21. Full-haplotype mismatched HSCT for high risk acute myeloid leukemia (AML)

Author

Aversa, Franco, Terenzi, A., Ballanti, S., Felicini, R., Carotti, A., Falcinelli, F., Tabilio, Antonio, Falzetti, Franca, Velardi, Andrea, Capponi, M., Santucci, A., and Martelli, Massimo Fabrizio

Subjects
trapianto incompatibile, celluel staminali ematopoieticheleucemia mieloide acuta
Published
2002

30. Mismatched hematopoietic stem cell transplants in elderly patients

Author

Tabilio, Antonio, Velardi, Andrea, Terenzi, A., Ballanti, S., Felicini, R., Carotti, A., Falcinelli, F., Falzetti, Franca, Minelli, O., and Martelli, Massimo Fabrizio

Subjects
paziente anziano, trapianto incompatibile, cellule staminali
Published
2000

38. Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum

Author

Aversa, F, Tabilio, Antonio, Terenzi, A, Velardi, A, Falzetti, F, Giannoni, C, Iacucci, R, Zei, T, Martelli, Maria Paola, Gambelunghe, C, and Aristei, Cynthia

Subjects
Adult, Male, Adolescent, T-Lymphocytes, medicine.medical_treatment, Immunology, Graft vs Host Disease, ThioTEPA, Biochemistry, Lymphocyte Depletion, successful engraftment of T-cell, Granulocyte Colony-Stimulating Factor, Humans, Transplantation, Homologous, Medicine, Progenitor cell, Child, Bone Marrow Transplantation, Leukemia, business.industry, Graft Survival, Hematopoietic Stem Cell Transplantation, Immunosuppression, Cell Biology, Hematology, Middle Aged, Total body irradiation, Hematopoietic Stem Cells, medicine.disease, Recombinant Proteins, Granulocyte colony-stimulating factor, Transplantation, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, Haplotypes, Host vs Graft Reaction, Histocompatibility, Female, Bone marrow, business, medicine.drug
Abstract

Patients who undergo transplantation with haploidentical “three-loci” mismatched T-cell-depleted bone marrow (BM) are at high risk for graft failure. To overcome the host-versus-graft barrier, we increased the size of the graft inoculum, which has been shown to be a major factor in controlling both immune rejection and stem cell competition in murine models. Seventeen patients (mean age, 23.2 years; range, 6 to 51 years) with end-stage chemoresistant leukemia were received transplants of a combination of BM with recombinant human granulocyte colony- stimulating factor-mobilized peripheral blood progenitor cells from HLA- haploidentical “three-loci” incompatible family members. The average concentration of colony-forming unit-granulocyte-macrophage in the final inoculum was sevenfold to 10-fold greater than that found in BM alone. The sole graft-versus-host disease (GVHD) prophylaxis consisted of T-cell depletion of the graft by the soybean agglutination and E- rosetting technique. The conditioning regimen included total body irradiation in a single fraction at a fast dose rate, antithymocyte globulin, cyclophosphamide and thiotepa to provide both immunosuppression and myeloablation. One patient rejected the graft and the other 16 had early and sustained full donor-type engraftment. One patient who received a much greater quantity of T lymphocytes than any other patient died from grade IV acute GVHD. There were no other cases of GVHD > or = grade II. Nine patients died from transplant-related toxicity, 2 relapsed, and 6 patients are alive and event-free at a median follow-up of 230 days (range, 100 to 485 days). Our results show that a highly immunosuppressive and myeloablative conditioning followed by transplantation of a large number of stem cells depleted of T lymphocytes by soybean agglutination and E-rosetting technique has made transplantation of three HLA-antigen disparate grafts possible, with only rare cases of GVHD.

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