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2. Airway Angiopoietin-2 in Ventilated Very Preterm Infants: Association With Prenatal Factors and Neonatal Outcome

Author

Thomas, Wolfgang, Seidenspinner, Silvia, Kramer, Boris W., Wirbelauer, Johannes, Kawczynska-Leda, Natalia, Szymankiewicz, Marta, Speer, Christian P., Kindergeneeskunde, and RS: GROW - School for Oncology and Reproduction

Subjects
angiogenesis, vascular endothelial growth factor, bronchopulmonary dysplasia, small for gestational age infant, lung injury
Abstract

Objective: Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin-2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE-2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE-2 (sTIE-2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin-TIE-2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality. Methods: We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW

Published
2011

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