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1. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Adamo, Sabrina, Holmes, Melissa F, Scott, Christopher J M, Gao, Fuqiang, Sunderland, Kelly M, McLaughlin, Paula, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H, Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E, Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C, Pollock, Bruce G, Rajji, Tarek K, Seitz, Dallas, Tang-Wai, David F, Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P, Grimes, David, Jog, Mandar, Steeves, Thomas D L, Arnott, Stephen R, Black, Sandra E, Finger, Elizabeth, Rabin, Jennifer, and Tartaglia, Maria Carmela

Subjects
White Matter/diagnostic imaging, Frontotemporal Dementia, Cognitive Dysfunction/psychology, Cerebrovascular Disorders/complications, Humans, Female, Parkinson Disease, Magnetic Resonance Imaging
Abstract

BACKGROUND: Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of white matter hyperintensities and cortical thickness to NPS in participants across neurodegenerative and cerebrovascular diseases.METHODS: Five hundred thirteen participants with one of these conditions, i.e. Alzheimer's Disease/Mild Cognitive Impairment, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson's Disease, or Cerebrovascular Disease, were included in the study. NPS were assessed using the Neuropsychiatric Inventory - Questionnaire and grouped into hyperactivity, psychotic, affective, and apathy subsyndromes. White matter hyperintensities were quantified using a semi-automatic segmentation technique and FreeSurfer cortical thickness was used to measure regional grey matter loss.RESULTS: Although NPS were frequent across the five disease groups, participants with frontotemporal dementia had the highest frequency of hyperactivity, apathy, and affective subsyndromes compared to other groups, whilst psychotic subsyndrome was high in both frontotemporal dementia and Parkinson's disease. Results from univariate and multivariate results showed that various predictors were associated with neuropsychiatric subsyndromes, especially cortical thickness in the inferior frontal, cingulate, and insula regions, sex(female), global cognition, and basal ganglia-thalamus white matter hyperintensities.CONCLUSIONS: In participants with neurodegenerative and cerebrovascular diseases, our results suggest that smaller cortical thickness and white matter hyperintensity burden in several cortical-subcortical structures may contribute to the development of NPS. Further studies investigating the mechanisms that determine the progression of NPS in various neurodegenerative and cerebrovascular diseases are needed.

Published
2023
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2. Rare neurovascular genetic and imaging markers across neurodegenerative diseases

Author

Dilliott, Allison A, Berberian, Stephanie A, Sunderland, Kelly M, Binns, Malcolm A, Zimmer, Julia, Ozzoude, Miracle, Scott, Christopher J M, Gao, Fuqiang, Lang, Anthony E, Breen, David P, Tartaglia, Maria C, Tan, Brian, Swartz, Richard H, Rogaeva, Ekaterina, Borrie, Michael, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Kumar, Sanjeev, Pasternak, Stephen, Pollock, Bruce G, Rajji, Tarek K, Tang-Wai, David F, Abrahao, Agessandro, Turnbull, John, Zinman, Lorne, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Grimes, David, Marras, Connie, Steeves, Thomas, Masellis, Mario, Farhan, Sali M K, Bartha, Robert, Symons, Sean, Hegele, Robert A, Black, Sandra E, and Ramirez, Joel

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) is common in patients with cognitive impairment and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated the burden of magnetic resonance imaging (MRI)-based markers of SVD in patients with neurodegenerative diseases as a function of rare genetic variant carrier status.METHODS: The Ontario Neurodegenerative Disease Research Initiative study included 520 participants, recruited from 14 tertiary care centers, diagnosed with various neurodegenerative diseases and determined the carrier status of rare non-synonymous variants in five genes (ABCC6, COL4A1/COL4A2, NOTCH3/HTRA1).RESULTS: NOTCH3/HTRA1 were found to significantly influence SVD neuroimaging outcomes; however, the mechanisms by which these variants contribute to disease progression or worsen clinical correlates are not yet understood.DISCUSSION: Further studies are needed to develop genetic and imaging neurovascular markers to enhance our understanding of their potential contribution to neurodegenerative diseases.

Published
2023
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3. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Holmes, Melissa F., Scott, Christopher J. M., Gao, Fuqiang, Sunderland, Kelly M., McLaughlin, Paula, Rabin, Jennifer, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H., Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E., Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C., Pollock, Bruce G., Rajji, Tarek K., Seitz, Dallas, Tang-Wai, David F., Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P., Grimes, David, Jog, Mandar, Steeves, Thomas D. L., Arnott, Stephen R., Black, Sandra E., Finger, Elizabeth, and Tartaglia, Maria Carmela

Subjects
Aging, Neurodegenerative disease, behavioral disciplines and activities, White Matter, Social cognition, Cortical thickness, Cerebrovascular Disorders, Frontotemporal Dementia, mental disorders, White matter hyperintensities, Humans, Original Article, Female, Atrophy, Empathy, Geriatrics and Gerontology, Cerebrovascular disease
Abstract

Change in empathy is an increasingly recognised symptom of neurodegenerative diseases and contributes to caregiver burden and patient distress. Empathy impairment has been associated with brain atrophy but its relationship to white matter hyperintensities (WMH) is unknown. We aimed to investigate the relationships amongst WMH, brain atrophy, and empathy deficits in neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with Alzheimer’s disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), Parkinson’s disease, or cerebrovascular disease (CVD) were included. Empathy was assessed using the Interpersonal Reactivity Index. WMH were measured using a semi-automatic segmentation and FreeSurfer was used to measure cortical thickness. A heterogeneous pattern of cortical thinning was found between groups, with FTD showing thinning in frontotemporal regions and CVD in left superior parietal, left insula, and left postcentral. Results from both univariate and multivariate analyses revealed that several variables were associated with empathy, particularly cortical thickness in the fronto-insulo-temporal and cingulate regions, sex (female), global cognition, and right parietal and occipital WMH. Our results suggest that cortical atrophy and WMH may be associated with empathy deficits in neurodegenerative and cerebrovascular diseases. Future work should consider investigating the longitudinal effects of WMH and atrophy on empathy deficits in neurodegenerative and cerebrovascular diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00539-x.

Published
2022
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4. White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

Author

Carvalho de Abreu, Daniela Cristina, Pieruccini-Faria, Frederico, Sarquis-Adamson, Yanina, Black, Alanna, Fraser, Julia, Van Ooteghem, Karen, Cornish, Benjamin, Grimes, David, Jog, Mandar, Masellis, Mario, Steeves, Thomas, Nanayakkara, Nuwan, Ramirez, Joel, Scott, Christopher, Holmes, Melissa, Ozzoude, Miracle, Berezuk, Courtney, Symons, Sean, Mohammad Hassan Haddad, Seyyed, Arnott, Stephen R, Binns, Malcolm, Strother, Stephen, Beaton, Derek, Sunderland, Kelly, Theyers, Athena, Tan, Brian, Zamyadi, Mojdeh, Levine, Brian, Orange, Joseph B, Roberts, Angela C, Lou, Wendy, Sujanthan, Sujeevini, Breen, David P, Marras, Connie, Kwan, Donna, Adamo, Sabrina, Peltsch, Alicia, Troyer, Angela K, Black, Sandra E, McLaughlin, Paula M, Lang, Anthony E, McIlroy, William, Bartha, Robert, and Montero-Odasso, Manuel

Abstract

BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (pCONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.

Published
2023
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5. Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A, McLaughlin, Paula M, Abrahao, Agessandro, Black, Sandra E, Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B, Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G, Rajji, Tarek K, Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D L, Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F, Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
Psychiatry and Mental health
Abstract

Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function. Methods We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD ( N = 111), CVD ( N = 148), PD ( N = 136), FTD ( N = 50) and ALS ( N = 36). We compared the frequency and severity of individual NPS (assessed by the neuropsychiatric inventory questionnaire) across cohorts using generalized estimating equations and analysis of variance. Second, we assessed the relationship of NPS burden with instrumental (iADLs) and basic (ADLs) activities of living across cohorts using multivariate linear regression while adjusting for relevant demographic and clinical covariates. Results Frequency of NPS varied across cohorts (χ2(4) = 34.4, p < .001), with post-hoc tests showing that FTD had the greatest frequency as compared to all other cohorts. The FTD cohort also had the greatest severity of NPS ( H(4) = 34.5, p < .001). Further, there were differences among cohorts in terms of the association between NPS burden and ADLs ( F(4,461) = 3.1, p = 0.02). Post-hoc comparisons suggested that this finding was driven by the FTD group, however, the differences did not remain significant following Bonferroni correction. There were no differences among cohorts in terms of the association between NPS burden and IADLs. Conclusions NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Published
2023
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6. sj-docx-1-nnr-10.1177_15459683231177606 – Supplemental material for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI

Author

Pieruccini-Faria, Frederico, Cornish, Benjamin, Binns, Malcolm, Fraser, Julia, Haddad, Seyyed M. H., Sunderland, Kelly, Ramirez, Joel, Beaton, Derek, Kwan, Donna, Dilliott, Allison A., Scott, Christopher, Sarquis-Adamson, Yanina, Black, Alanna, Van Ooteghem, Karen, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Tan, Brian, Hegele, Robert, Bulman, Dennis, Ghani, Mahdi, Robinson, John, Rogaeva, Ekaterina, Farhan, Sali, Symons, Sean, Nanayakkara, Nuwan, Arnott, Stephen R., Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Zamyadi, Mojdeh, Lou, Wendy, Sujanthan, Sujeevini, Bartha, Robert, Black, Sandra E., Swartz, Richard H., McIlroy, William, and Montero-Odasso, Manuel

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-nnr-10.1177_15459683231177606 for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI by Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M. H. Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A. Dilliott, Christopher Scott, Yanina Sarquis-Adamson, Alanna Black, Karen Van Ooteghem, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Brian Tan, Robert Hegele, Dennis Bulman, Mahdi Ghani, John Robinson, Ekaterina Rogaeva, Sali Farhan, Sean Symons, Nuwan Nanayakkara, Stephen R. Arnott, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Miracle Ozzoude, Mojdeh Zamyadi, Wendy Lou, Sujeevini Sujanthan, Robert Bartha, Sandra E. Black, Richard H. Swartz, William McIlroy and Manuel Montero-Odasso in Neurorehabilitation and Neural Repair

Published
2023
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7. sj-docx-2-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-2-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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8. sj-docx-1-nnr-10.1177_15459683231177606 – Supplemental material for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI

Author

Pieruccini-Faria, Frederico, Cornish, Benjamin, Binns, Malcolm, Fraser, Julia, Haddad, Seyyed M. H., Sunderland, Kelly, Ramirez, Joel, Beaton, Derek, Kwan, Donna, Dilliott, Allison A., Scott, Christopher, Sarquis-Adamson, Yanina, Black, Alanna, Van Ooteghem, Karen, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Tan, Brian, Hegele, Robert, Bulman, Dennis, Ghani, Mahdi, Robinson, John, Rogaeva, Ekaterina, Farhan, Sali, Symons, Sean, Nanayakkara, Nuwan, Arnott, Stephen R., Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Zamyadi, Mojdeh, Lou, Wendy, Sujanthan, Sujeevini, Bartha, Robert, Black, Sandra E., Swartz, Richard H., McIlroy, William, and Montero-Odasso, Manuel

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-nnr-10.1177_15459683231177606 for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI by Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M. H. Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A. Dilliott, Christopher Scott, Yanina Sarquis-Adamson, Alanna Black, Karen Van Ooteghem, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Brian Tan, Robert Hegele, Dennis Bulman, Mahdi Ghani, John Robinson, Ekaterina Rogaeva, Sali Farhan, Sean Symons, Nuwan Nanayakkara, Stephen R. Arnott, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Miracle Ozzoude, Mojdeh Zamyadi, Wendy Lou, Sujeevini Sujanthan, Robert Bartha, Sandra E. Black, Richard H. Swartz, William McIlroy and Manuel Montero-Odasso in Neurorehabilitation and Neural Repair

Published
2023
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9. sj-pdf-1-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-pdf-1-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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10. sj-docx-2-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-2-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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11. sj-docx-3-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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12. sj-docx-3-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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13. Geriatric dementia care at Ontario Shores: A new model of care

Author

Viau, Katelynn, Yaddaden, Amel, Lussier, Maxime, Bier, Nathalie, Earle, Julie, Duff-Woskosky, Andra, Bartfay, Wally, Desai, Chaitali, Zavitz, Karen, Horsburgh, Sheri, Gamble, Brenda, Lee, Linda, Hillier, Loretta M., Patel, Tejal, Molnar, Frank, Clarke, Jo-Anne, Borrie, Michael, Cammer, Allison, Morgan, Debra, Whiting, Susan, de Vos, Maya, Henri-Bhargava, Alexandre, Votova, Kristine, Delmar, Paul, Kerchner, Geoffrey A, Wang, Guoqiao, Bateman, Randall, Klein, Gregory, Andjelkovic, Mirjana, Abi-Saab, Danielle, Bullain, Szofia, Montoya, Alonso, Fontoura, Paulo, Doody, Rachelle, Tai, Elaine, Harvey, David, Hofmann, Carsten, Ristic, Smiljana, Rehal, Sunita, Voyle, Nicola, Baudler, Monika, Verreault, Phylicia, Rousseau, François, Keller, Evelyn, Simard, Alexandra, Azouaou, Nassima, Jarboui, Manel, Talleria, Lorraine, Duguay, Johanne, Mérette, Chantale, Labbé, Annie, de Arco, Rossana Peredo Nunez, Yous, Marie-Lee, Ploeg, Jenny, Kaasalainen, Sharon, Martin, Lori Schindel, Palumbo, Mary Val, Rambur, Betty, McKenna, Lori, Voyer, Philippe, Allaire, Émilie, Li, Bing, Thaut, Michael, Yogaparan, Thirumagal, Shanmuganathan, Thirunathan, Vickneswaran, Anicha, Sriharan, Sruthy, DeMarco, Mari L., Hsiung, Ging-Yuek Robin, Best, John R., Chertkow, Howard, Gauthier, Serge, Karlawish, Jason, Feldman, Howard, Spaner, Caroline, Christie, Brian, Musteata, Stela, Gawryluk, Jodie, Hofer, Scott, Henri-Bhargava, Alex, Kenny, Rebecca, Elliot, Valerie, Kosteniuk, Julie, Chow, Amanda Froehlich, Bayly, Melanie, O’Connell, Megan E., Kortzman, August, O’Connell, Megan, Kirk, Andrew, Conn, David, Sokoloff, Lisa, Feldman, Sid, Chau, James, Moser, Andrea, Lingum, Navena, Gingrich, Shaen, Shaikh, Salma, Rabheru, Kiran, Cassidy, Keri-Leigh, Checkland, Claire, Parsons, Daria, Massie, Ariane S., Mitchell, Julie Spence, Aksenchuk, Sophia, Lindsay, Barbara, Howard, Maria, Shaw, Courtney, Armitage, Gerrard, Capstick, Andrea, McNeil, Heather, Holyoke, Paul, Vines, Chanile, Giosa, Justine, Khan, Bilal, Shultz, Mary, BEAUCHET, Olivier, Sekhon, Harmehr, Allali, Gilles, Montembeault, Maxime, Brodeur, Catherine, Macoir, Joël, Maxwell, Colleen, Maclagan, Laura, Campitelli, Michael, Yao, Shenzhen, Dharma, Christoffer, Sherin, Tracey, Hogan, David, Bronskill, Susan, Ivo, Jessica, Faisal, Sadaf, McDougall, Aidan, Bauer, Jillian, Pritchard, Sarah, Chang, Feng, Mehta, Deval, Syed, Ali, Carter, Caitlin, Sharma, Shaambhavi, Nagge, Jeff, Naglie, Gary, Stasiulis, Elaine, Yamin, Stephanie, Vrkljan, Brenda, Tuokko, Holly, Sanford, Sarah, Porter, Michelle, Polgar, Jan, Myers, Anita, Moorhouse, Paige, Mazer, Barbara, Marshall, Shawn, Gélinas, Isabelle, Crizzle, Alexander, Byszewski, Anna, Belchior, Patricia, Bédard, Michel, Rapoport, Mark, Minish, Duane, Yetman, Linda, Stephenson, Margaret, McCloskey, Rose, Agbaku, Mansa, Jarrett, Pamela, Cavanagh, Jennifer, Loncar, Adele, Demers, Vickie, Gobessi, Linda, Lodha, Vinay, Scerbe, Andrea, Astell, Arlene, DesRoches, Andrea, Panyavin, Ivan, Feltz, Nick, Wittich, Walter, Aubin, Gabrielle, Hogan, Mariah, Swaminathan, Swathi, Altschuler, Aviva, Murphy, Kelly, Guthrie, Dawn, Williams, Nicole, Campos, Jennifer, Mick, Paul, Orange, Joseph B., Pichora-Fuller, M. Kathleen, Savundranayagam, Marie Y., Phillips, Natalie A., Giroud, Nathalie, Pichora-Fuller, Kathy, Al-Yawer, Faisal, Rehan, Sana, Phillips, Natalie, Beauchet, Olivier, Niculescu, Iulia, Iaboni, Andrea, Quirt, Hannah, Penko, Marion, Tsokas, Mario, Marshall, Cecelia, Flint, Alastair, McGilton, Katherine, O’Connell, Megan E, Stewart, Norma J, Seitz, Dallas, Daku, Jean, Hack, Tracy, Hoium, Faye, Kennett-Russill, Deb, Sauter, Kristen, Holley, Joanna, Wimhurst, Christine, Katchaluba, Janet, Mitchell, Debbie, Severina, Elmira, Dallaire-Théroux, Caroline, Saikali, Stéphan, Duchesne, Simon, Sivananthan, Saskia, Mirza, Saira, Saeed, Usman, Knight, Jo, Ramirez, Joel, Stuss, Donald, Yu, Di, Swardfager, Walter, Keith, Julia, Nestor, Sean, Black, Sandra, Masellis, Mario, Joyal, Marilyne, Kotz, Sonja A., Lenglos, Christophe, Renauld, Emmanuelle, Wilson, Maximiliano A., Fecteau, Shirley, Appel, Lora, Kisonas, Erika, Appel, Eva, Bartlett, Deanna, Klein, Jennifer, Rosenberg, Jarred, Smith, Christopher, Ali, Suad, Narang, Tanya, Wiseman, Micaela, Ein, Natalie, Orchanian-Cheff, Ani, Rylett, Jane, Hogan, David B., Rockwood, Kenneth, Dixon, Roger, Sun, Winnie, Hawkins, Stacey A., Awde, Carolee, Kay, Kelly, Huntsbarger, Deana, Ferrier, Erin, Sourial, Nadia, Arsenault-Lapierre, Genevieve, McAiney, Carrie, Vedel, Isabelle, Ingram, K. Jennifer, Frank, Andrew, Sabra, Iman, Wallace, Bruce, Breau, Michael, Sweet, Lisa, Goubran, Rafiq, Knoefel, Frank, Goubran, Rafik, Stroulia, Eleni, Ault, Laura, Kecskemet, Judith, Guseva, Elena, Lungu, Ovidiu, Goldman, Sondra, Wilchesky, Machelle, Johri, Fozia, Turner, Angelese, Lavoie, Monica, Tang-Wai, David, Leonard, Carol, Graham, Naida L., Rochon, Elizabeth, Middleton, Laura, Herrmann, Nathan, Oh, Paul, Regan, Kayla, Bechard, Lauren, Lanctôt, Krista, Freeman, Shannon, Pettersen, Jacqueline, Tomasone, Jennifer, Dupuis, Sherry, Giangregorio, Lora, Ferris, Rebecca, Stultz, Tim, Mallard, Kirsten, Campbell, Elaine, Chatterjee, Atri, Mackenzie, Ian, Reinshagen, Veronica Hirsh, Ducharme, Blake, Mousavi, Ali, Gill, Sascha, Mouches, Pauline, Wang, Meng, Rajasheskar, Deepthi, MacMaster, Frank, Forkert, Nils, Smith, Eric, Ismail, Zahinoor, Varatharajah, Breni, Camicioli, Richard, Gee, Myrlene, Zwiers, Angela, Sekhon, Ramnik, Charlton, Anna, Arsenault-Lapierre, Geneviève, Ingram, Jennifer, Hawkins, Stacey, Mousavi, SeyedAli, Mackenzie, Ian R. A., Hirsh-Reinshagen, Veronica, Hsiung, Ging-Yuek. R., Gillingham, Susan M.E., Anderson, Nicole D., Alain, Claude, Georgievski, Georgi, Alfaro, Leonardo, McClenaghan, Meridith, Soares, Daniela, Matheson, Maureen, Stanoulis, Krisanne, Boyle, Daniel, Chau, Linh, Pelc, Jordan, Snash, Nadia, Byrne, Joanne, Elalouf, Karine, Alfaro, Andrea Urqueta, Johnson, Aaron, Marinier, Julie-Andrée, Kehayia, Eva, Gagné, Jean-Pierre, Murphy, Caitlin, Ellen, Ruth, Flowers, Brandi, Boulton, Karen Lee, Subotic, Arsenije, McCreary, Cheryl R., Nguyen, Amanda, Saad, Feryal, Alvarez, Ana, Beaudin, Andrew E, Pike, Bruce, Smith, Eric E, Hu, Sophie, Patten, Scott, Fick, Gordon, Sapkota, Shraddha, Mirza, Saira Saeed, Scott, Christopher J., Stuss, Donald T., Black, Sandra E., Le Blanc, Gabriella, Ducharme, Simon, Meilleur-Durand, Synthia, Lévesque, Marianne, St-Onge, Frédéric, Cunnane, Stephen, Villeneuve, Sylvia, Callahan, Brandy, Laforce, Robert, Cetin-Sahin, Deniz, Cummings, Greta G., Schuster, Tibor, Karanofsky, Mark, De Jesus, Belmir J., Cassani, Raymundo, Cecchi, Marco, Fadem, K. C., McGeown, William J., Falk, Tiago H., Chu, Charlene, Zdaniuk, Natalia, Wang, Rosalie, Ouellet, Marie-Christine, Cassivi-Joncas, Alison, Godard-Sebillotte, Claire, Rochette, Louis, Pelletier, Eric, Strumpf, Erin, Margo-Dermer, Eva, Silver, Hilah, Vafaei, Rod, Fok, Alice C, Hsiung, Ging-Yuek R., Ursenbach, Jake, Bethell, Jennifer, Neuman, Mark D, Bateman, Brian T, Hill, Andrea, Wunsch, Hannah, Ritchie, Kim, Cramm, Heidi, Aiken, Alice, Donnelly, Catherine, Goldie, Katie, Delara, Mahin, Ozzoude, Miracle, Varriano, Brenda, McLaughlin, Paula, Troyer, Angela, Bartha, Robert, Symons, Sean, Kwan, Donna, Tan, Brian, Swartz, Richard H., Saposnik, Gustavo, Tartaglia, Maria C., Ahuja, Manan, Siddhpuria, Shailee, Gormley, Jessica, Reppas, Christina, Wong, Eric, Lee, Justin, Patterson, Christopher, Walker, Jennifer, Warry, Wayne, Blind, Melissa, Allaby, Cheryl, Pitawanakwat, Karen, Zhao, Yantao, Lemieux, Andrine, Jacklin, Kristen, Crowshoe, Lindsay, Boehme, Gail, McKenna, Betty, Boyling, Elaine, Webkamigad, Sharlene, Bigeagle, Louise, Akan, Nicole, Wallace, Lindsay, Theou, Olga, Bennett, David, Darvesh, Sultan, Kirkland, Susan, Fisk, John, Andrew, Melissa, Cullen, Stephanie, Carroll, Susan, Mahon, Joel, Sarquis-Adamson, Yanina, Montero-Odasso, Manuel, Sharma, Nabina, Beaton, Derek, Roberts, Angela, Munoz, Doug, Swartz, Richard, Breen, David, Lang, Anthony, Fischer, COrrine, Fischer, Corrine, Kumar, Sanjeeve, Freedman, Morris, Finger, Elizabeth, Zinman, Lorne, Grimes, David A., Sunderland, Kelly M., Binns, Malcolm A., Strother, Stephen C., Mandzia, Jennifer, Orange, JB, Tartaglia, Carmela, El Shatshat, Amna, Rao, Praveen P.N., Teves, Julia, Bodkin, R Jack, Ho, Joanne M-W, Mehdizadeh, Sina, Dolatabadi, Elham, Ng, Kimberley-Dale, Arora, Twinkle, Jizmejian, Melody, Mansfield, Avril, Taati, Babak, Levy, Jake, Savard, Melissa, Pascoal, Tharick, Soucy, Jean-Paul, Rosa-Neto, Pedro, Martins, Felicia, Waller, Shannon, Flora, Parminder, Morland, Chris, Donovan, Steve, Fels, Deborah, Desai, Shital, Boger, Jennifer, Shashtri, Karan, Persaud, Deanna, Marashi, Sheida, Nedlund, Ann-Charlotte, Mäki-Petäjä-Leinonen, Anna, Nygård, Louise, Issakainen, Mervi, ryd, Charlotta, Pan, Yuhan, Joddrell, Phil, Dove, Erica, Owens, Hollis, Park, Elly, Liu, Lili, Kaufman, David, Simonian, Natalie, Chen, Ying, Sunderland, Kelly, Fraser, Julia, Swartz, Rick, Strother, Stephen, Legrand, Diego, Roberge, Pasquale, Vanasse, Alain, Bocti, Christian, Pirrie, Lorraine, Gray, Carolyn Steele, Nippak, Pria, Coughlan, Dave, Teselink, Johannes, Hermann, Nathan, Rasquinha, Fawn, Lanctot, Krista, Webber, Jodi, Woo, Kevin, Chamoun, Elicia, Coulombe, Valérie, Sellami, Leila, Paquette-Raynard, Emmanuelle, Gardner, Sandra, van Zon, Lorraine, Moy, Sally, Sidrak, Mariam, Sternhill, Janis, Feldman, Sidney, Karuza, Jurgis, Berall, Anna, Thomas, Neil, Mattek, Nora, Riley, Thomas, Reynolds, Christina, Marcoe, Jennifer, Sharma, Nicole, Kaye, Jeffrey, Jagtap, Shreya, Rotenberg, Shlomit, Vandermorris, Susan, Anderson, ND, Dawson, DR, Chater, Catherine, Soor, Jaspreet, Ji, Xiang, Koo, Morgan, Compagnone, Jordana, Kertes, Peter, Juby, Angela, Mager, Diana, Davis, Christopher, Jay, David, Blackburn, Toni, Brocks, Dion, Lee, Hyunwoo, Wiggermann, Vanessa, Rauscher, Alexander, Lam, Kevin, Tam, Roger, Popuri, Karteek, Beg, Mirza Faisal, Jacova, Claudia, Sossi, Vesna, Bindra, Jessica, Bouvier, Liziane, Monetta, Laura, Vitali, Paolo, Martel-Sauvageau, Vincent, Godin, Judith, McNeil, Shelly, McElhaney, Janet, Laughton, Thomas, Ho, Joanne, Tung, Jennifer, Dubé, Joseph B., Lin, Tianzhen, Best, Sarah, Truemner, Julia, Sargeant, Patricia L., Borrie, Michael J., Fogarty, Jennifer, Bassi, Nimi, Di Prospero, Cynthia, Whitehead, Victor, Pilon, Randi, Wong, Timothy, Elhayek, Nada, Dasgupta, Monidipa, Davis, Daniel, ORegan, Niamh, Kröger, Edeltraut, Furrer, Daniela, Wilcheski, Machelle, Morin, Michèle, Carmichael, Pierre-Hugues, Champoux, Nathalie, Monette, Johanne, Giguère, Anik, Aubin, Michèle, Durand, Pierre, Whiteside, Jena, Mele, Bria, Merrikh, Daria, Goodarzi, Zahra, Seary, Judith Anne, Bulley, Heather, Diciacca, Allison, Esseltine, Julia, Gaiger, Erin, Jankovic, Ivana, Mackenzie, Stephanie, McBride, Meghan, Knopp-Sihota, Jennifer A., Hoben, Mathias, Poss, Jeffrey W., Rachor, Geoffrey S., Estabrooks, Carole A., and Iroanyah, Ngozi

Subjects
Abstracts: Posters
Published
2020

14. The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project

Author

Sunderland, Kelly M., Beaton, Derek, Fraser, Julia, Kwan, Donna, McLaughlin, Paula M., Montero-Odasso, Manuel, Peltsch, Alicia J., Pieruccini-Faria, Frederico, Sahlas, Demetrios J., Swartz, Richard H., Bartha, Robert, Black, Sandra E., Borrie, Michael, Corbett, Dale, Finger, Elizabeth, Freedman, Morris, Greenberg, Barry, Grimes, David A., Hegele, Robert A., Hudson, Chris, Lang, Anthony E., Masellis, Mario, McIlroy, William E., Munoz, David G., Munoz, Douglas P., Orange, J. B., Strong, Michael J., Symons, Sean, Tartaglia, Maria Carmela, Troyer, Angela, Zinman, Lorne, and Strother, Stephen C.

Subjects
Multivariate statistics, Multivariate analysis, Epidemiology, Computer science, Principal component analysis, Datasets as Topic, Health Informatics, Multivariate outliers, Machine learning, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Covariate, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Minimum covariance determinant, Gait, Visualization, Ontario, lcsh:R5-920, Models, Statistical, business.industry, 030503 health policy & services, Dementia, Vascular, Univariate, Quality control, Neurodegenerative Diseases, 3. Good health, Data Accuracy, Data quality, Data Interpretation, Statistical, Outlier, Multivariate Analysis, Anomaly detection, Artificial intelligence, 0305 other medical science, business, Gait Analysis, lcsh:Medicine (General), Robust principal component analysis, computer, Research Article
Abstract

Background Large and complex studies are now routine, and quality assurance and quality control (QC) procedures ensure reliable results and conclusions. Standard procedures may comprise manual verification and double entry, but these labour-intensive methods often leave errors undetected. Outlier detection uses a data-driven approach to identify patterns exhibited by the majority of the data and highlights data points that deviate from these patterns. Univariate methods consider each variable independently, so observations that appear odd only when two or more variables are considered simultaneously remain undetected. We propose a data quality evaluation process that emphasizes the use of multivariate outlier detection for identifying errors, and show that univariate approaches alone are insufficient. Further, we establish an iterative process that uses multiple multivariate approaches, communication between teams, and visualization for other large-scale projects to follow. Methods We illustrate this process with preliminary neuropsychology and gait data for the vascular cognitive impairment cohort from the Ontario Neurodegenerative Disease Research Initiative, a multi-cohort observational study that aims to characterize biomarkers within and between five neurodegenerative diseases. Each dataset was evaluated four times: with and without covariate adjustment using two validated multivariate methods – Minimum Covariance Determinant (MCD) and Candès’ Robust Principal Component Analysis (RPCA) – and results were assessed in relation to two univariate methods. Outlying participants identified by multiple multivariate analyses were compiled and communicated to the data teams for verification. Results Of 161 and 148 participants in the neuropsychology and gait data, 44 and 43 were flagged by one or both multivariate methods and errors were identified for 8 and 5 participants, respectively. MCD identified all participants with errors, while RPCA identified 6/8 and 3/5 for the neuropsychology and gait data, respectively. Both outperformed univariate approaches. Adjusting for covariates had a minor effect on the participants identified as outliers, though did affect error detection. Conclusions Manual QC procedures are insufficient for large studies as many errors remain undetected. In these data, the MCD outperforms the RPCA for identifying errors, and both are more successful than univariate approaches. Therefore, data-driven multivariate outlier techniques are essential tools for QC as data become more complex. Electronic supplementary material The online version of this article (10.1186/s12874-019-0737-5) contains supplementary material, which is available to authorized users.

Published
2019
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15. Bilingualism in Parkinson's disease: Relationship to cognition and quality of life

Author

Fishman, Keera N., Roberts, Angela C., Orange, J. B., Sunderland, Kelly M., Marras, Connie, Tan, Brian, Steeves, Thomas, Kwan, Donna, Lang, Anthony E., Grimes, David, Levine, Brian, Masellis, Mario, Binns, Malcolm A., Jog, Mandar, Strother, Stephen C., McLaughlin, Paula M., Troyer, Angela K., Bartha, Robert, Black, Sandra E., Borrie, Michael, Corbett, Dale, Finger, Elizabeth, Freedman, Morris, Greenberg, Barry, Hegele, Robert A., Hudson, Chris, McIlroy, William E., Montero-Odasso, Manuel, Munoz, David G., Munoz, Douglas P., Strong, Michael J., and Swartz, Richard H.

Subjects
cognition, neuropsychological tests, Adult, Male, Parkinson's disease, Bilingualism, Multilingualism, Neuropsychological Tests, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, Executive Function, 0302 clinical medicine, Quality of life (healthcare), Cognition, medicine, Humans, 0501 psychology and cognitive sciences, Neuroscience of multilingualism, Cognitive reserve, Aged, language, 05 social sciences, Parkinson Disease, medicine.disease, Parkinson disease, Clinical Psychology, Neurology, executive function, quality of life, Quality of Life, Female, Neurology (clinical), Psychology, 030217 neurology & neurosurgery
Abstract

Some studies have found that bilingualism promotes cognitive reserve. Objective: We aimed to determine whether bilingualism, defined as regularly (i.e. daily) using at least two languages at least since early adulthood, is associated with cognitive advantages in Parkinson’s disease (PD) or whether the possible benefits of bilingualism are lost in the context of PD, possibly affecting quality of life (QoL) and independence. Method: Participants with idiopathic PD (n = 140, mean age = 67.9 [SD = 6.4], 78% men) completed standard neuropsychological tasks evaluating attention/working memory, language, executive function, memory, and visuospatial ability, as well as measures of wellbeing and functional independence. Results: Bilinguals with PD (n = 21) performed worse than monolinguals with PD (n = 92) on attention/working memory and language measures. The between-group differences in attention/working memory were restricted to verbally-based measures. When measured along a continuum, a higher degree of bilingualism was correlated with lower scores on measures of attention/working memory and language. There were no group differences in self- or informant-reported cognitive decline, PD health-related QoL, or functional independence. Conclusions: Bilingualism in PD was not associated with better cognitive performance. Lower scores on language-based measures may reflect a distributed fund of linguistic information across more than one language, lower language proficiency in English, and/or other cultural artifacts. Furthermore, using normative data specific to the dominant language spoken or conducting neuropsychological testing in participants’ self-reported most proficient language may enhance additional studies addressing this topic. Future research may also examine the roles of bilingualism over time and across other neurodegenerative diseases with and without EF impairment to illuminate further the impact of bilingualism on cognition and QoL, and shape culturally and linguistically diverse research and clinical care.

Published
2021

19. ONDRI_NPSY_QA_QC_Supplementary_R.2 – Supplemental material for The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study

Author

McLaughlin, Paula M., Sunderland, Kelly M., Beaton, Derek, Binns, Malcolm A., Kwan, Donna, Levine, Brian, Orange, Joseph B., Peltsch, Alicia J., Roberts, Angela C., Strother, Stephen C., and Troyer, Angela K.

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, 16. Peace & justice, 3. Good health, FOS: Sociology
Abstract

Supplemental material, ONDRI_NPSY_QA_QC_Supplementary_R.2 for The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study by Paula M. McLaughlin, Kelly M. Sunderland, Derek Beaton, Malcolm A. Binns, Donna Kwan, Brian Levine, Joseph B. Orange, Alicia J. Peltsch, Angela C. Roberts, Stephen C. Strother and Angela K. Troyer in Assessment

20. ONDRI_NPSY_QA_QC_Supplementary_R.2 – Supplemental material for The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study

Author

McLaughlin, Paula M., Sunderland, Kelly M., Beaton, Derek, Binns, Malcolm A., Kwan, Donna, Levine, Brian, Orange, Joseph B., Peltsch, Alicia J., Roberts, Angela C., Strother, Stephen C., and Troyer, Angela K.

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, 16. Peace & justice, 3. Good health, FOS: Sociology
Abstract

Supplemental material, ONDRI_NPSY_QA_QC_Supplementary_R.2 for The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study by Paula M. McLaughlin, Kelly M. Sunderland, Derek Beaton, Malcolm A. Binns, Donna Kwan, Brian Levine, Joseph B. Orange, Alicia J. Peltsch, Angela C. Roberts, Stephen C. Strother and Angela K. Troyer in Assessment

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