159 results on '"Sugiyama, K."'
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2. iStent Trabecular Micro-Bypass Stent Implantation with Cataract Surgery in a Japanese Glaucoma Population
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Nitta K, Yamada Y, Morokado S, and Sugiyama K
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Ophthalmology ,genetic structures ,trabecular micro-bypass ,istent ,normal-tension glaucoma ,microinvasive glaucoma surgery (migs) ,japanese ,sense organs ,RE1-994 ,eye diseases - Abstract
Koji Nitta,1 Yutaro Yamada,1 Satomi Morokado,1 Kazuhisa Sugiyama2 1Department of Ophthalmology, Fukui-Ken Saiseikai Hospital, Fukui, Fukui Prefecture, Japan; 2Department of Ophthalmology, Kanazawa University, Kanazawa, Ishikawa Prefecture, JapanCorrespondence: Koji NittaFukui-Ken Saiseikai Hospital, Funabashi 7-1, Wadanaka-Cho, Fukui City, Fukui 918-8503, JapanTel +81 776 23 1111Email nitta.koji7001@fukui.saiseikai.or.jpIntroduction: This study assesses two-year efficacy and safety following implantation of a single trabecular micro-bypass stent (iStent®) with concomitant phacoemulsification cataract surgery in Japanese patients with open-angle glaucoma (OAG).Materials and Methods: This retrospective, consecutive case series included eyes that underwent iStent implantation with phacoemulsification and were followed for 24 months postoperative. Efficacy and safety measures included intraocular pressure (IOP), number of glaucoma medications, adverse events, secondary surgeries, visual fields, and endothelial cell counts.Results: Of 73 operated eyes, 53 eyes had 24 months of follow-up and are analyzed. Diagnoses included primary open-angle glaucoma (POAG, n=25), normal-tension glaucoma (NTG, n=16), and pseudoexfoliative glaucoma (PXG, n=12). At 24 months, mean IOP reduced by 18% to 13.6± 3.0 mmHg versus 16.5± 3.4 mmHg preoperatively (p< 0.0001), and mean medication number reduced by 81% to 0.37± 0.74 versus 1.96± 0.98 preoperatively (p< 0.0001). The percentage of medication-free eyes was 77% versus 0% preoperatively, and 81% of eyes had IOP ≤ 15 mmHg versus 42% preoperatively. Results were similarly favorable across glaucoma subtypes (POAG, NTG, PXG). Notably, mean IOP in NTG eyes decreased to 12.8± 1.4 mmHg from 14.4± 3.0 mmHg preoperatively (p=0.03), and medications decreased by 87% to 0.31± 0.70 versus 2.38± 0.72 preoperatively (p< 0.0001). At 24 months, 81% of NTG eyes were medication-free (versus 0% preoperatively); 2 NTG eyes (13%) were on ≥ 2 medications (versus 100% preoperatively). Throughout the follow-up, visual fields and endothelial cell counts remained stable; 1 eye (1.9%) underwent filtration surgery.Discussion: Favorable safety and significant IOP and mediation reductions were achieved through two years following iStent implantation with phacoemulsification in a Japanese population. These gains were achieved across all glaucoma subtypes (including POAG, NTG, PXG).Conclusion: This real-world study supports the viability of iStent implantation to treat Japanese patients with glaucoma and shows that the benefits extend to those with NTG or PXG in addition to POAG.Keywords: microinvasive glaucoma surgery, MIGS, iStent, trabecular micro-bypass, Japanese, normal-tension glaucoma
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- 2020
3. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
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Li Bassi, G., Gibbons, K., Suen, J. Y., Dalton, H. J., White, N., Corley, A., Shrapnel, S., Hinton, S., Forsyth, S., Laffey, J. G., Fan, E., Fanning, J. P., Panigada, M., Bartlett, R., Brodie, D., Burrell, A., Chiumello, D., Elhazmi, A., Esperatti, M., Grasselli, G., Hodgson, C., Ichiba, S., Luna, C., Marwali, E., Merson, L., Murthy, S., Nichol, A., Ogino, M., Pelosi, P., Torres, A., P. Y., Ng, Fraser, J. F., Al-Dabbous, T., Alfoudri, H., Shamsah, M., Elapavaluru, S., Berg, A., Horn, C., Mayasi, Y., Schroll, S., Meyer, D., Velazco, J., Ploskanych, L., Fikes, W., Bagewadi, R., Dao, M., White, H., Ehlers, A., Shalabi-McGuire, M., Witt, T., Grazioli, L., Lorini, L., Grandin, E. W., Nunez, J., Reyes, T., Obriain, D., Hunter, S., Ramanan, M., Affleck, J., Veerendra, H. H., Rai, S., Russell-Brown, J., Nourse, M., Joseph, M., Mitchell, B., Tenzer, M., Abe, R., Cho, H. J., Jeong, I. S., Rahman, N., Kakar, V., Brozzi, N., Mehkri, O., Krishnan, S., Duggal, A., Houltham, S., Graf, J., Diaz, R., Orrego, R., Delgado, C., Gonzalez, J., Sanchez, M. S., Piagnerelli, M., Sarrazin, J. V., Zabert, A. /P. G., Espinosa, L., Delgado, P., Delgado, V., Rincon, D. F. B., Yanten, A. M. M., Duque, M. B., Al-Hudaib, A., Callahan, M., Taufik, M. A., Wardoyo, E. Y., Gunawan, M., Trisnaningrum, N. S., Irawany, V., Rayhan, M., Pesenti, A., Zanella, A., Leone, M., Coppola, S., Colombo, S., Antonelli, M., Carelli, S., Grieco, D. L., Asaki, M., Hoshino, K., Salazar, L., Duarte, L., Laffey, J., Mcnicholas, B., Cosgrave, D., Mccaffrey, J., Bone, A., Hakeem, Y., Winearls, J., Tallott, M., Thomson, D., Arnold-Day, C., Cupido, J., Fanie, Z., Miller, M., Seymore, L., van Straaten, D., Hssain, A. A., Aliudin, J., Alqahtani, A. -R., Mohamed, K., Mohamed, A., Tan, D., Villanueva, J., Zaqout, A., Kurtzman, E., Ademi, A., Dobrita, A., El Aoudi, K., Segura, J., Giwangkancana, G., Ohshimo, S., Hitoshi, S., Osatnik, J., Joosten, A., Yang, M., Motos, A., Arancibia, F., Williams, V., Noel, A., Luque, N., Trung, T. H., Yacoub, S., Fantini, M., Garcia, R. N. J., Alvarez, E. C., Greti, A., Ceccato, A., Sanchez, A., Vazquez, A. L., Roche-Campo, F., Franch-Llasat, D., Tuazon, D., Amato, M., Cassimiro, L., Pola, F., Ribeiro, F., Fonseca, G., Dalton, H., Desai, M., Osborn, E., Deeb, H., Arcadipane, A., Martucci, G., Panarello, G., Vitiello, C., Bianco, C., Occhipinti, G., Rossetti, M., Cuffaro, R., Cho, S. -M., Shimizu, H., Moriyama, N., Kim, J. -B., Kitamura, N., Gebauer, J., Yokoyama, T., Al-Fares, A., Buabbas, S., Alamad, E., Alawadhi, F., Alawadi, K., Tanaka, H., Hashimoto, S., Yamazaki, M., T. -H., Oh, Epler, M., Forney, C., Kruse, L., Feister, J., Williamson, J., Grobengieser, K., Gnall, E., Golden, S., Caroline, M., Shapiro, T., Karaj, C., Thome, L., Sher, L., Vanderland, M., Welch, M., Mcdermott, S., Brain, M., Mineall, S., Kimura, D., Brazzi, L., Sales, G., Ogston, T., Nagpal, D., Fischer, K., Lorusso, R., Rangappa, R., Appu, A., Carton, E. G., Sen, A., Palacios, A., Rainey, D., Samoukoviv, G., Campisi, J., Durham, L., Neumann, E., Seefeldt, C., Falcucci, O., Emmrich, A., Guy, J., Johns, C., Potzner, K., Zimmermann, C., Espinal, A., Buchtele, N., Schwameis, M., Stecher, S. -S., Singh, D., Barnikel, M., Arenz, L., Zaaqoq, A., Galloway, L. A., Merley, C., Csete, M., Quesada, L., Saba, I., Kasugai, D., Hiraiwa, H., Tanaka, T., Purnama, Y., Dewayanti, S. R., Ardiyan, Juzar, D. A., Siagian, D., Chen, Y. -S., Ratsep, I., Oigus, G., Erikson, K., Post, A. -M., Enneveer, L., Sillaots, P., Manetta, F., Mihelis, E., Sarmiento, I. C., Narasimhan, M., Varrone, M., Komats, M., Garcia-Diaz, J., Harmon, C., Satyapriya, S. V., Bhatt, A., Mokadam, N. A., Uribe, A., Gonzalez, A., Shi, H., Mckeown, J., Pasek, J., Fiorda, J., Echeverria, M., Moreno, R., Zakhary, B., Cavana, M., Cucino, A., Foti, G., Giani, M., Russotto, V., Castagna, V., Dellamore, A., Navalesi, P., Shum, H. -P., Vuysteke, A., Usman, A., Acker, A., Smood, B., Mergler, B., Sertic, F., Subramanian, M., Sperry, A., Rizer, N., Burhan, E., Rasmin, M., Akmal, E., Sitompul, F., Lolong, N., Naivedh, B., Erickson, S., Barrett, P., Dean, D., Daugherty, J., Loforte, A., Khan, I., Abraar Quraishi, M., Desantis, O., So, D., Kandamby, D., Mandei, J. M., Natanael, H., Yudhalantang, E., Lantang, A., Wijaya, S. O., Jung, A., Ng, G., W. Y., Ng, Fang, S., Tabah, A., Ratcliffe, M., Duroux, M., Adachi, S., Nakao, S., Blanco, P., Prieto, A., Sanchez, J., Nicholson, M., Butt, W., Serratore, A., Delzoppo, C., Janin, P., Yarad, E., Totaro, R., Coles, J., Pujo, B., Balk, R., Vissing, A., Kapania, E., Hays, J., Fox, S., Yantosh, G., Mishin, P., Yuliarto, S., Hari Santoso, K., Djajalaksana, S., Fatoni, A. Z., Fukuda, M., Liu, K., Battaglini, D., Jimenez, J. F. M., Bastos, D., Gaiao, S., Rusmawatiningtyas, D., Buchner, J., Cho, Y. -J., Lee, S. H., Kawasaki, T., Munshi, L., Sakiyalak, P., Nitayavardhana, P., Seitz, T., Arora, R., Kent, D., Marino, D., Parwar, S., Cheng, A., Miller, J., Fujitani, S., Shimizu, N., Madhok, J., Owyang, C., Buscher, H., Reynolds, C., Maasikas, O., Beljantsev, A., Mihnovits, V., Akimoto, T., Aizawa, M., Horibe, K., Onodera, R., Young, M., George, T., Shekar, K., Mcguinness, N., Irvine, L., Flynn, B., Endo, T., Sugiyama, K., Shimizu, K., Exconde, K., Lussier, L., Lotz, G., Malfertheiner, M., Maier, L., Dreier, E., Kusumastuti, N. P., Mccloskey, C., Dabaliz, A. -A., Elshazly, T. B., Smith, J., Szuldrzynski, K. S., Bielanski, P., Wille, K., Parhar, K. K. S., Fiest, K. M., Codan, C., Shahid, A., Fayed, M., Evans, T., Garcia, R., Gutierrez, A., Song, T., Rose, R., Bennett, S., Richardson, D., Peek, G., Arora, L., Rappapport, K., Rudolph, K., Sibenaller, Z., Stout, L., Walter, A., Herr, D., Vedadi, N., Thompson, S., Sindt, L., Rajnic, S., Ewald, C., Hoffman, J., Ying, X., Kennedy, R., Griffee, M., Ciullo, A., Kida, Y., Roca, R. F., Riera, J. I., Contreras, S., Alegre, C., Kay, C., Fischer, I., Renner, E., Taniguci, H., Fraser, J., Bassi, G. L., Suen, J., Barnett, A., Pearse, I., Abbate, G., Hassan, H., Heinsar, S., Karnik, V. A., Ki, K., Oneill, H. F., Obonyo, N., Pimenta, L. P., Reid, J. D., Sato, K., Vuorinen, A., Wildi, K. S., Wood, E. S., Yerkovich, S., Lee, J., Plotkin, D., Citarella, B. W., Hartley, E., Lubis, B., Ikeyama, T., Bhaskar, B., Jung, J. -S., Mcguinness, S., Eastwood, G., Marta, S. R., Guarracino, F., Gerle, S., Coxon, E., Claro, B., Loverde, D., Patil, N., Parrini, V., Mcbride, A., Negaard, K., Ratsch, A., Abdelaziz, A., Uribe, J. D., Peris, A., Sanders, M., Emerson, D., Kamal, M., Povoa, P., Francis, R., Cherif, A., Joseph, S., Di Nardo, M., Heard, M., Kyle, K., Blackwell, R. A., Biston, P., Jeong, H. W., Smith, R., Prawira, Y., Montrucchio, G., Garcia, A. H., Salterain, N., Meyns, B., Moreno, M., Walia, R., Mehta, A., Schweda, A., Supriatna, M., Kirakli, C., Williams, M., Kim, K. H., Assad, A., Giraldo, E., Karolak, W., Balik, M., Pocock, E., Gajkowski, E., Masafumi, K., Barrett, N., Takeyama, Y., Park, S., Amin, F., Andriyani, F. M., Sudakevych, S., Vera, M., Cornejo, R., Schwarz, P., Mardini, A. C., de Paula, T., Neto, A. S., Villoldo, A., Colafranceschi, A. S., Iglesias, A. U., Granjean, J., Melro, L. M. G., Romualdo, G. F., Gaia, D., Souza, H., Galas, F., Mendiluce, R. M., Sosa, A., Martinez, I., Kurosawa, H., Salgado, J., Hugi-MayrCharbonneau, B. E., Barzilai, V. S., Monteiro, V., de Souza, R. R., Harper, M., Suzuki, H., Adams, C., Brieva, J., Nyale, G., Eltatar, F. S., Fatani, J., Baeissa, H., Masri, A. A., Rabie, A., Hui, M. Y., Yamane, M., Jung, H., Margaret, A. M., Nacpil, N., Ruck, K., Bakken, R., Jara, C., Felton, T., Berra, L., Shah, B., Chakraborty, A., Cardona, M., Capatos, G., Akkanti, B., Orija, A., Jain, H., Ito, A., Housni, B., Low, S., Iihara, K., Chavez, J., Ramanathan, K., Zabert, G., Naidoo, K., Seppelt, I., Vandyk, M., Macdonald, S., Mcgregor, R., Siebenaler, T., Flynn, H., Lofton, K., Aokage, T., Shigemitsu, K., Moscatelli, A., Fiorentino, G., Baumgaertel, M., Mba, S. E., Assy, J., Hutahaean, A., Roush, H., Sichting, K. A., Alessandri, F., Burns, D., Salt, G., Garabedian, C. P., Millar, J., Sim, M., Mattke, A., Mcauley, D., Tadili, J., Frenzel, T., Bar-Lavie, Y., Ortiz, A. B., Stone, J., Attokaran, A., Farquharson, M., Patel, B., Gunning, D., Baillie, K., Watson, P., Tamai, K., Sajinadiyasa, G. K., Kanyawati, D., Salgado, M., Sassine, A., Yudo, B., Mccaul, S., Lee, B., Lee, S. M., Afek, A., Iwashita, Y., Semedi, B. P., Metiva, J., Van Belle, N., Martin-Loeches, I., Ivatt, L., Woon, C. Y., Kang, H. M., Smith, T., James, E., Al-Rawas, N., Iwasaki, Y., King-Chung, K. C., Gudzenko, V., Hugi-Mayr, B., Taccone, F., Perdhana, F., Lamarche, Y., Ribeiro, J. M., Bradic, N., Van den Bossche, K., Lansink, O., Singh, G., Debeuckelaere, G., Stelfox, H. T., Yi, C., Elia, J., Tribble, T., Shankar, S., Padmanabhan, R., Hallinan, B., Paoletti, L., Leyva, Y., Fykuda, T., Badulak, J., Koch, J., Hackman, A., Janowaik, L., Hernandez, D., Osofsky, J., Donadello, K., Lawang, A., Fine, J., Davidson, B., Vazquez, A. O. R., COVID-19 Critical Care Consortium, and Consortium, COVID-19 Critical Care
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Male ,Respiratory Distress Syndrome ,COVID-19 ,Intensive care unit ,Mechanical ventilation ,Neuromuscular blocking agent ,SARS-CoV-2 ,Aged ,Female ,Humans ,Intensive Care Units ,Middle Aged ,Propensity Score ,Respiration, Artificial ,Neuromuscular Blocking Agents ,Respiration ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Settore MED/41 - Anestesiologia ,Critical Care and Intensive Care Medicine ,COVID-19 Drug Treatment ,Artificial ,Human medicine - Abstract
Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. Results Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0–25) and 25 (IQR 7–26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0–87) and 87 (IQR 0–88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p = 0.177). Conclusions In patients with COVID-19 and moderate-to-severe ARDS, short course of NMBA treatment, applied early, did not significantly improve 90-day mortality and VFD. In the absence of definitive data from clinical trials, NMBAs should be indicated cautiously in this setting.
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- 2022
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4. Visibility of the Retina Through an Air-Filled Anterior Chamber During Simultaneous Vitrectomy and Descemet’s Stripping Automated Endothelial Keratoplasty
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Yokogawa H, Kobayashi A, Mori N, Nishino T, and Sugiyama K
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descemet’s stripping automated endothelial keratoplasty ,pars plana vitrectomy ,Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Hideaki Yokogawa, Akira Kobayashi, Natsuko Mori, Tsubasa Nishino, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanCorrespondence: Hideaki YokogawaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa-shi, Ishikawa-ken 920-8641, JapanTel +81-76-265-2403Fax +81-76-222-9660Email hyoko@med.kanazawa-u.ac.jpPurpose: To describe the visibility of the retina through an air-filled anterior chamber during simultaneous pars plana vitrectomy (PPV) and Descemet’s stripping automated endothelial keratoplasty (DSAEK), and to discuss the technical challenges of a fluid-air exchange under such conditions.Methods: Six eyes from 6 patients with coexisting bullous keratopathy and posterior segment problems such as vitreous opacity, retained silicon oil, intraocular lens subluxation, or aphakia underwent simultaneous PPV and DSAEK. In all cases, after completion of 25-gauge PPV with/without flanged intrascleral intraocular lens fixation, DSAEK donor tissue was inserted into the anterior chamber. Air was then injected into the anterior chamber to attach the donor graft to the back surface of the host cornea. At this point, the visibility of the retina was evaluated using endoillumination and a wide-angle viewing system.Results: In all cases, visibility of the retina through an air-filled anterior chamber, with the DSAEK donor attached, was sufficient to perform a fluid-air exchange.Conclusion: Our clinical observations of such rare but clinically important conditions indicate that simultaneous PPV and DSAEK is possible with fair visualization of the posterior segment including the retina.Keywords: Descemet’s stripping automated endothelial keratoplasty, pars plana vitrectomy
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- 2020
5. Predicting Lifetime Transition Risk of Severe Visual Field Defects Using Monte Carlo Simulation in Japanese Patients with Primary Open-Angle Glaucoma
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Nitta K, Tachibana G, Wajima R, Inoue S, Ohigashi T, Otsuka N, Kurashima H, Santo K, Hashimoto M, Shibahara H, Hirukawa M, and Sugiyama K
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Ophthalmology ,glaucoma ,genetic structures ,risk factors ,epidemiology ,prognosis ,RE1-994 ,simulation - Abstract
Koji Nitta,1,2 Gaku Tachibana,1,2 Ryotaro Wajima,1,2 Sachie Inoue,3 Tatsuya Ohigashi,4 Naomi Otsuka,4 Hiroaki Kurashima,4 Kazunori Santo,4 Masayo Hashimoto,4 Hidetoshi Shibahara,3 Mai Hirukawa,3 Kazuhisa Sugiyama2 1Department of Ophthalmology, Fukui-Ken Saiseikai Hospital, Fukui, Japan; 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 3CRECON Medical Assessment Inc., Tokyo, Japan; 4Japan Medical Affairs Group, Santen Pharmaceutical Co., Ltd., Osaka, JapanCorrespondence: Koji Nitta Email nitta.koji7001@fukui.saiseikai.or.jpPurpose: To maintain visual fields and quality of life over a lifetime, medical practice must be conducted taking into consideration not only visual field progression but also future visual field changes that occur over the patients’ expected lifespan. The purpose of this study is to investigate the feasibility of establishing a model that predicts prognosis, estimating the proportion of glaucoma patients with severe visual field defects.Patients and Methods: The data of 191 patients with primary open-angle glaucoma, with a predominance of normal-tension glaucoma, were used for this study. The model was developed based on patients’ backgrounds and risk factors, using Monte Carlo simulation. A “severe visual field defect” was defined as ≤-20 dB. The mean deviation (MD) value for 10,000 virtual patients in each simulation pattern (144 patterns) was calculated using a predictive formula to estimate the MD slope, and the effects of risk factors and intraocular pressure (IOP) reduction on the proportion of patients with severe visual field defects were evaluated.Results: Younger age, later-stage disease, more severe glaucomatous structural abnormalities and the presence of disc hemorrhage were associated with an increase in the progression rate of patients with severe visual field defects. Conversely, lower IOP was associated with a decrease in this rate.Conclusion: Combining regression analysis with Monte Carlo simulation could be a useful method for developing predictive models of prognosis in glaucoma patients.Keywords: glaucoma, epidemiology, prognosis, risk factors, simulation
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- 2020
6. The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients
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Nitta K, Shimamoto S, Wajima R, Tachibana G, Yamada Y, Domoto M, Takeda R, Takahashi Y, and Sugiyama K
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brimonidine ,Ophthalmology ,primary open-angle glaucoma ,disc hemorrhage ,normal-tension glaucoma ,RE1-994 ,intraocular pressure - Abstract
Koji Nitta,1,2 Shiro Shimamoto,3 Ryotaro Wajima,2 Gaku Tachibana,2 Yutaro Yamada,1,2 Miyuki Domoto,1 Ryuji Takeda,4,5 Yoshinari Takahashi,6 Kazuhisa Sugiyama2 1Fukui-ken Saiseikai Hospital, Fukui, Japan; 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 3Shimamoto Ophthalmology Clinic, Fukui, Japan; 4Department of Nutritional Sciences for Well-Being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Osaka, Japan; 5Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nara, Japan; 6Inary Co., Ltd., Tokyo, JapanCorrespondence: Koji NittaDepartment of Ophthalmology, Fukui-ken Saiseikai Hospital, 7-1 Funabashi, Wadanaka-cho, Fukui 918-8503, JapanTel +81 776 23 1111Fax +81 776 28 8515Email nitta.koji7001@fukui.saiseikai.or.jpBackground: This retrospective study evaluated the effect of adjunctive administration of brimonidine 0.1% on disc hemorrhage (DH) in patients with primary open-angle glaucoma or normal-tension glaucoma who were already treated with other anti-glaucoma drugs.Methods: Patients with DH, before adjunctive therapy with brimonidine, were enrolled. Subjects were excluded if their treatment regimen was changed within 1 year after initiation of adjunctive therapy with brimonidine. We investigated the frequency of DH and intraocular pressure (IOP). Both parameters were compared before and after adjunctive administration of brimonidine.Results: The frequency of DH before and after brimonidine administration was 0.67± 0.68 and 0.31± 0.72 times/year, respectively, with a significant decrease (P=0.01), and the mean IOP before and after brimonidine administration was 12.5± 1.9 and 11.2± 2.2 mmHg, respectively, (P=0.0006) with a significant reduction after adjunctive administration.Conclusion: The results of this study supported the hypothesis that the frequency of DH is reduced by brimonidine alongside lowering of IOP.Keywords: disc hemorrhage, intraocular pressure, brimonidine, primary open-angle glaucoma, normal-tension glaucoma
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- 2020
7. A locked mode indicator for disruption prediction on JET and ASDEX upgrade
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Sias, G., Cannas, B., Fanni, A., Murari, A., Pau, A., Kallenbach, A., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Arredondo Parra, R., Asunta, O., de Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bobkov, V., Bock, A., Bogomolov, A., Bolzonella, T., Boeswirth, B., Bottereau, C., Bottino, A., van den Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I., Clairet, F., Classen, I., Coda, S., Coelho, R., Coenen, J. W., Colas, L., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D'Arcangelo, O., Day, C., Delogu, R., de Marne, P., Denk, S., Denner, P., Dibon, M., D'Inca, R., Di Siena, A., Douai, D., Drenik, A., Drube, R., Dunne, M., Duval, B. 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J., Lehmann, J., Leichtle, D., Leichuer, P., Lengar, I., Lennholm, M., Lerche, E., Lescinskis, A., Lesnoj, S., Letellier, E., Leysen, W., Likonen, J., Linke, J., Linsmeier, C., Liu, G., Lo Schiavo, V. P., Lobel, R. C., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lopez-Razola, J., Lorenzini, R., Losada, U., Lovell, J. J., Loving, A. B., Lowry, C., Luce, T., Lucock, R. M. A., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Macdonald, N., Macheta, P., Maczewa, K., Magesh, B., Makkonen, T., Makwana, R., Malaquias, A., Malizia, A., Manning, A., Manzanares, A., Maquet, P., Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marinelli, M., Marot, L., Marren, C. A., Marshal, R., Martin, A., Martin de Aguilera, A., Martinez, F. J., Martin-Solis, J. R., Martynova, Y., Maruyama, S., Masiello, A., Maslov, M., Matejcik, S., Matthews, G. F., Maviglia, F., May-Smith, T., Mazzotta, C., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mcintosh, S., Mckean, R., Mckehon, J., Meadows, R. C., Meakins, A., Medina, F., Medland, M., Medley, S., Meigh, S., Meigs, A. G., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merrigan, I. R., Mertens, P., Meshchaninov, S., Messiaen, A., Mianowski, S., Michling, R., Middleton-Gear, D., Militello-Asp, E., Miloshevsky, G., Minucci, S., Miyoshi, Y., Moneti, M., Mooney, R., Moradi, S., Mordijck, S., Moreira, L., Moreno, R., Moro, F., Morris, A. W., Morris, J., Moser, L., Mosher, S., Muraro, A., Murphy, S., Asakura, N. N., Y. S., Na, Naish, R., Nakano, T., Nave, M. F. F., Nedzelski, I., Nemtsev, G., Neto, A., Neverov, V. S., Newman, M., Nicholls, K. J., Nicolas, T., Nielsen, P., Nilsson, E., Nishijima, D., Noble, C., Nodwell, D., Nordlund, K., Nordman, H., Nunes, I., Odupitan, T., Ogawa, M. T., O'Gorman, T., Okabayashi, M., Olney, R., Omolayo, O., O'Mullane, M., Ongena, J., Orsitto, F., Orszagh, J., Oswuigwe, B. 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M., Formisano, A., Forsythe, L., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Foster, S., Franke, T., Franklin, T., Frasca, M., Freisinger, M., Fresa, R., Fuchs, V., Fuller, D., Fyvie, J., Gal, K., Galassi, D., Gallagher, J., Galvao, R., Gao, X., Gaudio, P., Gear, D. F., Gee, S. J., Gelfusa, M., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Giacalone, J. C., Gibson, C. S., Giegerich, T., Gil, C., Gil, L., Gilligan, S., Gin, D., Girardo, J. B., Giruzzi, G., Godwin, J., Goff, J., Gohil, P., Goloborod'Ko, V., Gomes, R., Goncalves, B., Goniche, M., Goodliffe, M., Goodyear, A., Gosk, M., Goulding, R., Goussarov, A., Gowland, R., Graham, B., Graham, M. E., Graves, J. P., Grazier, N., Grazier, P., Green, N. R., Grierson, B., Griph, F. S., Grisolia, C., Grist, D., Grove, R., Grundy, C. N., Grzonka, J., Guard, D., Guerard, C., Guillemaut, C., Gurl, C., Utoh, H. H., Hackett, L. J., Hagar, A., Hager, R., Halitovs, M., Hall, S. J., Hallworth Cook, S. 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T. C., Hoshino, K. K., Kamiya, K., Kaniewski, J., Kantor, A., Karkinsky, D., Karnowska, I., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V., Keeling, D. L., Keenan, T., Keep, J., Kempenaars, M., Kennedy, C., Kenny, D., Kent, J., Kent, O. N., Khilkevich, E., Kim, H. T., Kim, H. S., Kinch, A., King, C., King, D., King, R. F., Kinna, D. J., Kiptily, V., Kirov, K., Kirschner, A., Kizane, G., Klepper, C., Klix, A., Knight, P., Knipe, S. J., Knott, S., Kobuchi, T., Koechl, F., Kodeli, I., Kogan, L., Koivuranta, S., Kominis, Y., Koeppen, M., Kos, B., Koskela, T., Kovari, M., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V., Kresina, M., Kruezi, U., Ksiazek, I., Kukushkin, A., Kundu, A., Kwak, S., Kwiatkowski, R., Kwon, O. J., Laing, A., Lam, N., Lambertz, H. T., Lane, C., Lanthaler, S., Lapins, J., Lasa, A., Last, J. R., Laszynska, E., Lawless, R., Lawson, A., Lawson, K. D., Lazzaro, E., Lee, S., Lefebvre, X., Leggate, H. 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A., Reynolds, S., Riccardo, V., Richardson, N., Riddle, K., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Roach, C., Robins, R. J., Robinson, S. A., Robinson, T., Robson, D. W., Roccella, R., Rodionov, R., Rodrigues, P., Rodriguez, J., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rowe, S., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruset, C., Rzadkiewicz, J., Safi, E., Sagar, P., Saibene, G., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Schlummer, T., Schmidt, V., Schmuck, S., Schoepf, K., Schworer, D., Scott, S. D., Sergienko, G., Sharapov, S. E., Shaw, A., Shaw, R., Sheikh, H., Shepherd, A., Shevelev, A., Shumack, A., Sibbald, M., Silburn, S., Simmons, P. A., Simpson-Hutchinson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Slabkowska, K., Slade, B., Smith, N., Smith, P. G., Smith, R., Smith, T. 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D., Zerbini, M., Zhou, Y., Zilli, E., Zoita, V., Zychor, I., ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, EUROfusion MST1 Team, JET Contributors, Sias, G, Cannas, B, Fanni, A, Murari, A, Pau, A, Kallenbach, A, Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Arredondo Parra, R, Asunta, O, de Baar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, 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- Subjects
Disruption prediction ,Tokamak ,Offset (computer science) ,Computer science ,Feature extraction ,Disruption indicators ,01 natural sciences ,Signal ,010305 fluids & plasmas ,law.invention ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,ASDEX Upgrade ,law ,Control theory ,0103 physical sciences ,General Materials Science ,010306 general physics ,Locked mode signal ,Civil and Structural Engineering ,Jet (fluid) ,Mechanical Engineering ,[SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment ,Settore FIS/01 - Fisica Sperimentale ,Mode (statistics) ,Amplitude ,Nuclear Energy and Engineering ,Disruption indicator - Abstract
International audience; The aim of this paper is to present a signal processing algorithm that, applied to the raw Locked Mode signal, allows us to obtain a disruption indicator in principle exploitable on different tokamaks. A common definition of such an indicator for different machines would facilitate the development of portable systems for disruption prediction, which is becoming of increasingly importance for the next tokamak generations. Moreover, the indicator allows us to overcome some intrinsic problems in the diagnostic system such as drift and offset. The behavior of the proposed indicator as disruption predictor, based on crossing optimized thresholds of the signal amplitude, has been analyzed using data of both JET and ASDEX Upgrade experiments. A thorough analysis of the disruption prediction performance shows how the indicator is able to recover some missed and tardy detections of the raw signal. Moreover, it intervenes and corrects premature or even wrong alarms due to, e.g., drifts and/or offsets.
- Published
- 2019
8. Changing indications and surgical techniques for keratoplasty during a 16-year period (2003–2018) at a tertiary referral hospital in Japan
- Author
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Nishino T, Kobayashi A, Yokogawa H, Mori N, and Sugiyama K
- Subjects
Ophthalmology ,Descemet’s membrane endothelial keratoplasty ,RE1-994 ,Descemet’s stripping automated endothelial keratoplasty ,Penetrating keratoplasty - Abstract
Tsubasa Nishino, Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Kazuhisa SugiyamaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To present the changing indications and surgical techniques for keratoplasty during a 16-year period (2003–2018) at a tertiary referral hospital in Japan.Methods: Consecutive keratoplasty cases at Kanazawa University Hospital from January 2003 to December 2018 were retrospectively reviewed. Keratoplasty procedures included penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), anterior lamellar keratoplasty (ALK), Descemet’s stripping automated endothelial keratoplasty (DSAEK), and Descemet’s membrane endothelial keratoplasty (DMEK). Annual numbers and types of keratoplasty as well as underlying diseases for PK and total keratoplasty procedures were recorded, and annual trends were statistically analyzed using Cochran–Armitage test for trend.Results: A total of 801 keratoplasty procedures (PK, 319 cases; DALK, 57 cases; ALK, 9 cases; DSAEK, 371 cases; and DMEK 45 cases; mean age, 66.9±16.3 years) were performed for 595 patients (302 males [329 eyes, 419 cases], 293 females [345 eyes, 382 cases]) during the 16-year period. The proportion of PK procedures decreased significantly in the beginning and showed a slightly increasing trend after a plateau around 2015. DSAEK was increasing after 2006 and reached a plateau around 2012. Among 10 underlying diseases for total keratoplasty, corneal opacity and dermoid were decreasing linearly. Failed PK and failed DSAEK were increasing linearly in the beginning and reached a plateau followed by a decreasing trend. In terms of the underlying disease for PK, bullous keratopathy was decreasing in the beginning and reached a plateau around 2015. A total of 19 PK procedures were performed on cases with recalcitrant bullous kerstopathy (BK) after 2010.Conclusion: The distribution of keratoplasty procedures and underlying diseases changed significantly over 16 years at a tertiary referral hospital in Japan. PK procedure was significantly decreased and DSAEK procedure was significantly increased. PK for BK decreased significantly; however, PK remains a viable option for other recalcitrant corneal diseases.Keywords: Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, penetrating keratoplasty  
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- 2019
9. Surgery-induced iris abnormalities after Descemet membrane endothelial keratoplasty and their impact on postoperative clinical outcomes
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Mori N, Yokogawa H, Kobayashi A, Nishino T, and Sugiyama K
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Ophthalmology ,Surgery-induced iris abnormalities ,DMEK ,RE1-994 - Abstract
Natsuko Mori,1,2 Hideaki Yokogawa,1 Akira Kobayashi,1 Tsubasa Nishino,1,3 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 2Department of Ophthalmology, Saiseikai Kanazawa Hospital, Kanazawa, Japan; 3Department of Ophthalmology, Toyama Prefectural Central Hospital, Toyama, JapanPurpose: This study aimed to elucidate the frequency of surgery-induced iris abnormalities after Descemet membrane endothelial keratoplasty (DMEK) and their impact on postoperative clinical outcomes.Methods: In this retrospective study, medical records of 32 eyes from 28 consecutive patients (mean age, 65.7±13.4years; 14 men, 18 women) who underwent DMEK (or triple DMEK) were reviewed. In all patients, inferior peripheral iridectomy was created leaving full intracameral air tamponade at the end of surgery. Sulfur hexafluoride gas was not used in any cases. Surgery-induced iris abnormalities such as pupillary shape changes and iris depigmentation were evaluated by 3 masked observers. Pre-existing abnormalities were excluded. Eyes were divided into two groups based on the presence of surgery-induced iris changes: Group A (with iris abnormalities) and Group B (without). Impacts on postoperative clinical outcomes such as vision and endothelial cell density were analyzed.Results: Surgery-induced iris abnormalities were seen in 15 eyes (Group A, 9 with pupillary shape change and 6 with iris depigmentation; 46.9%), and 17 eyes showed no abnormalities (Group B, 53.1%). No significant differences were detected between groups in age, sex, indication, simultaneous cataract surgery, pre- and 6-month postoperative vision, donor age, donor endothelial cell density, and 6- and 12-month postoperative endothelial cell density.Conclusions: Surgery-induced iris abnormalities were noted in almost half of the eyes after DMEK (46.9%) in this study. However, there was no association between visual outcomes or postoperative endothelial cell density and the iris changes.Keywords: surgery-induced iris abnormalities, DMEK
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- 2019
10. A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
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Nishino T, Kobayashi A, Yokogawa H, Mori N, Masaki T, and Sugiyama K
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Ophthalmology ,argon laser iridotomy ,Descemet’s membrane endothelial keratoplasty ,RE1-994 ,Descemet’s stripping automated endothelial keratoplasty - Abstract
Tsubasa Nishino, Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan. Study design: A single-center, retrospective case series. Methods: We retrospectively reviewed all medical records of bullous keratopathy (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Changes or modifications to the annual number of EK procedures and underlying diseases were analyzed. Results: During this period, 320 EK procedures (DSAEK: 288 cases, DMEK: 32 cases) were performed on 250 patients. Total annual EKs gradually increased from 19 to 45 cases between 2007 and 2016. The annual number of DSAEKs was stable, although the proportion of DSAEKs to other procedures decreased significantly as re-DSAEKs and DMEKs increased. BK after argon laser iridotomy (ALI) was the leading cause in 2007, followed by Fuchs’ endothelial dystrophy (FED) and failed penetrating keratoplasty. In 2016, BK after trabeculectomy (TLE) was most prevalent, followed by failed DSAEK, failed penetrating keratoplasty, and pseudophakic BK. The decreased ALI and FED, and increased BK after TLE and failed DSAEK were statistically significant. Conclusion: The distribution of EK procedures (DSAEK/DMEK) and underlying diseases changed over 10 years at a tertiary referral hospital in Japan. The proportion of re-DSAEK and DMEK increased among all EK procedures. Most significantly, among the underlying diseases, decreased ALI and FED and increased TLE and failed DSAEK were observed. Extended multicenter analysis may further elucidate the changes in EK procedures and the causes of BK in Japan. Keywords: argon laser iridotomy, trabeculectomy, reoperation, Fuchs’ endothelial dystrophy
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- 2018
11. Air-insufflated high-definition dacryoendoscopy yields significantly better image quality than conventional dacryoendoscopy
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Sasaki T, Sounou T, Tsuji H, and Sugiyama K
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high-definition dacryoendoscopy ,Ophthalmology ,emphysema ,pressure-controlled air-insufflated ,RE1-994 ,saline irrigated dacryoendoscopy - Abstract
Tsugihisa Sasaki,1 Tsutomu Sounou,2 Hideki Tsuji,3 Kazuhisa Sugiyama4 1Sasaki Eye Clinic, Mikuni, Sakai, 2Department of Ophthalmology, Keiju Kanazawa Hospital, 3Department of Ophthalmology, Cancer Institute Hospital, 4Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To facilitate the analysis of lacrimal conditions, we utilized high-definition dacryoendoscopy (HDD) and undertook observations with a pressure-controlled air-insufflation system. We report the safety and performance of HDD.Methods: In this retrospective, non-randomized clinical trial, 46 patients (14 males and 32 females; age range 39–91 years; mean age ± SD 70.3±12.0 years) who had lacrimal disorders were examined with HDD and conventional dacryoendoscopy (CD). The high-definition dacryoendoscope had 15,000 picture element image fibers and an advanced objective lens. Its outer diameter was 0.9–1.2 mm. Air insufflation was controlled at 0–20 kPa with a digital manometer-based pressure-controlled air-insufflation system to evaluate the quality of the image. The HDD had an air/saline irrigation channel between the outer sheath (outer diameter =1.2 mm) and the metal inner sheath of the endoscope. We used it and the CD in air, saline, and diluted milk saline with and without manual irrigation to quantitatively evaluate the effect of air pressure and saline irrigation on image quality.Results: In vivo, the most significant improvement in image quality was demonstrated with air-insufflated (5–15 kPa) HDD, as compared with saline-irrigated HDD and saline-irrigated CD. No emphysema or damage was noted under observation with HDD. In vitro, no significant difference was demonstrated between air-insufflated HDD and saline-irrigated HDD. In vitro, the image quality of air-insufflated HDD was significantly improved as compared with that of saline-irrigated CD.Conclusion: Pressure-controlled (5–15 kPa) air-insufflated HDD is safe, and yields significantly better image quality than CD and saline-irrigated HDD. Keywords: pressure-controlled air-insufflated, high-definition dacryoendoscopy, saline-irrigated dacryoendoscopy, emphysema
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- 2017
12. Association of fluorescein anterior corneal mosaic and corneal K-structures by in vivo laser confocal microscopy in patients with keratoconus
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Kobayashi A, Yokogawa H, Mori N, Masaki T, and Sugiyama K
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Ophthalmology ,anterior corneal mosaic ,genetic structures ,K-structure ,keratoconus ,sense organs ,RE1-994 ,confocal microscopy ,eye diseases - Abstract
Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of corneas with keratoconus, with special attention to abnormality of Bowman’s layer and sub-Bowman’s fibrous structures (Kobayashi-structures [K-structures]).Methods: Sixteen keratoconic eyes in 8 consecutive patients with keratoconus (4males, 4females, mean age, 41.1 years) were included in this study. Slit-lamp biomicroscopic photos were taken with or without fluorescein staining. The existence of anterior corneal mosaic (ACM) after eyelid rubbing under fluorescein staining was documented. In vivo laser confocal microscopic examinations were performed for all patients in both the central cone and the peripheral cornea to examine the existence of K-structures.Results: According to the Amsler–Krumeich scale, the eyes were graded as follows: stage1 (n=3), stage 2 (n=1), stage 3 (n=1), and stage 4 (n=11). ACM was observed in 7 eyes (61.1%) in the cone area and 16 eyes (100%) in the peripheral cornea among all keratoconic eyes enrolled in this study. In addition, K-structures were observed in the 7 eyes (61.1%) and 16 eyes (100%) in the peripheral cornea among all keratoconic eyes. The presence of the K-structures was completely matched (100%) with the presence of ACM in both the central cone and the peripheral cornea. In 11 eyes with stage 4 keratoconus, ACM and K-structure was absent in 9 eyes (81.8%) in the cone area. On the contrary, in 5 eyes with mild-to-moderate keratoconus (grade 1 to3), ACM and K-structure was present in all eyes (100%) in the cone area. The absent ratio of ACM and K-structures in the cone area was significantly higher in stage 4 severe keratoconus compared to mild-to-moderate keratoconus (grade1to3) (Fisher, P=0.005).Conclusion: The existence of ACM and K-structures in both the central cone and the peripheral cornea showed perfect accord in patients with keratoconus, indicating a strong association of ACM and K-structures in patients with keratoconus. With the progress of the keratoconus, it seemed that ACM and K-structure progressively disappeared, suggesting Bowman’s layer abnormalities due to keratoconus. Further study in larger groups of patients with keratoconus is required to fully understand the significance of ACM/K-structures in keratoconic eyes and their association with Bowman’s layer. Keywords: keratoconus, anterior corneal mosaic, K-structure, confocal microscopy 
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- 2017
13. Is high myopia a risk factor for visual field progression or disk hemorrhage in primary open-angle glaucoma?
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Nitta K, Sugiyama K, Wajima R, and Tachibana G
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Ophthalmology ,visual field defect progression ,genetic structures ,myopic glaucoma ,disc hemorrhage ,open angle glaucoma ,sense organs ,RE1-994 ,high myopia ,eye diseases - Abstract
Koji Nitta,1 Kazuhisa Sugiyama,2 Ryotaro Wajima,1 Gaku Tachibana1 1Department of Ophthalmology, Fukui-ken Saiseikai Hospital, Fukui, 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: The purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients.Patients and methods: A total of 269 POAG patients were divided into two groups: patients with ≥26.5mm of axial length (highly myopic group) and patients with
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- 2017
14. Sub-arcsecond (Sub)millimeter Imaging of the Massive Protocluster G358.93‚àí0.03: Discovery of 14 New Methanol Maser Lines Associated with a Hot Core
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Brogan, C., Hunter, T., Towner, A., McGuire, B., MacLeod, G., Gurwell, M., Cyganowski, C., Brand, J., Burns, R., Caratti o Garatti, A., Chen, X., Chibueze, J., Hirano, N., Hirota, T., Kim, K., Kramer, B., Linz, H., Menten, K., Remijan, A., Sanna, A., Sobolev, A., Sridharan, T., Stecklum, B., Sugiyama, K., Surcis, G., Van der Walt, J., Volvach, A., and Volvach, L.
- Abstract
We present (sub)millimeter imaging at 0.″5 resolution of the massive star-forming region G358.93−0.03 acquired in multiple epochs at 2 and 3 months following the recent flaring of its 6.7 GHz CH3OH maser emission. Using the Submillimeter Array and Atacama Large Millimeter/submillimeter Array, we have discovered 14 new Class II CH3OH maser lines ranging in frequency from 199 to 361 GHz, which originate mostly from {v}t = 1 torsionally excited transitions and include one {v}t = 2 transition. The latter detection provides the first observational evidence that Class II maser pumping involves levels in the {v}t = 2 state. The masers are associated with the brightest continuum source (MM1), which hosts a line-rich hot core. The masers present a consistent curvilinear spatial velocity pattern that wraps around MM1, suggestive of a coherent physical structure 1200 au in extent. In contrast, the thermal lines exhibit a linear pattern that crosses MM1 but at progressive position angles that appear to be a function of either increasing temperature or decreasing optical depth. The maser spectral profiles evolved significantly over one month, and the intensities dropped by factors of 3.0-7.2, with the {v}t = 2 line showing the largest change. A small area of maser emission from only the highest excitation lines closest to MM1 has disappeared. There are seven additional dust continuum sources in the protocluster, including another hot core (MM3). We do not find evidence for a significant change in (sub)millimeter continuum emission from any of the sources during the one month interval, and the total protocluster emission remains comparable to prior single-dish measurements.
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- 2019
15. Mapping of dendritic lesions in patients with herpes simplex keratitis using in vivo confocal microscopy
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Yokogawa H, Kobayashi A, Mori N, and Sugiyama K
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Ophthalmology ,sense organs ,RE1-994 ,eye diseases - Abstract
Hideaki Yokogawa, Akira Kobayashi, Natsuko Mori, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To produce a two-dimensional reconstruction map of dendritic lesions in patients with herpes simplex keratitis (HSK) using in vivo confocal microscopy.Methods: Four eyes of four patients (mean 65.8 years) with HSK presenting with a dendritic lesion were enrolled. Slit-lamp biomicroscopy and in vivo laser confocal microscopy were performed. Acquired confocal images at the level of the epithelium were arranged and mapped into subconfluent montages. Changes in the shape and degree of light reflection of abnormal cells and deposits around dendritic lesions as well as other corneal layers were qualitatively evaluated.Results: Mapping of dendritic lesion was successful in all cases, and the subconfluent montages clearly showed the larger image of dendritic lesion. In all cases, the dendritic lesion consisted of hyperreflective irregular epithelial cells, and was surrounded by distorted and elongated epithelial cells. In three cases, hyperreflective deposits were noted at the midline of the lesion. The corneal stroma showed a hyperreflective honeycomb pattern. In two cases, inflammatory cells were observed at the level of endothelial cell layer.Conclusion: Mapping of dendritic lesions in patients with HSK was successful in all patients using in vivo confocal microscopy. Cellular level observation of dendritic lesion at a relatively larger magnification may help understand the in vivo morphological change of HSK. Further study in more patients with HSK and nonherpetic dendritic lesion is needed to utilize confocal microscopy images in differential diagnosis and follow-up of the epithelial lesions with dendrite. Keywords: herpetic epithelial keratitis, in vivo confocal microscopy, fluorescein slit-lamp photograph, hyperreflective irregular epithelial cells, dendritic lesion
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- 2015
16. Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure: the supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial
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Sakata, Yasuhiko, Shiba, Nobuyuki, Takahashi, Jun, Miyata, Satoshi, Nochioka, Kotaro, Miura, Masanobu, Takada, Tsuyoshi, Saga, Chiharu, Shinozaki, Tsuyoshi, Sugi, Masafumi, Nakagawa, Makoto, Sekiguchi, Nobuyo, Komaru, Tatsuya, Kato, Atsushi, Fukuchi, Mitsumasa, Nozaki, Eiji, Hiramoto, Tetsuya, Inoue, Kanichi, Goto, Toshikazu, Ohe, Masatoshi, Tamaki, Kenji, Ibayashi, Setsuro, Ishide, Nobumasa, Maruyama, Yukio, Tsuji, Ichiro, Shimokawa, Hiroaki, Shimokawa, H., Fukuchi, M., Goto, T., Hiramoto, T., Inoue, K., Kato, A., Komaru, T., Ohe, M., Sekiguchi, N., Shiba, N., Shinozaki, T., Sugi, M., Tamaki, K., Ogata, M., Sato, S., Ishide, N., Ibayashi, S., Maruyama, Y., Ohno, I., Ogawa, H., Kitakaze, M., Tsuji, I., Watanabe, T., Sugiyama, K., Oyama, S., Nozaki, E., Nakamura, A., Takahashi, T., Endo, H., Fukui, S., Nakajima, S., Nakagawa, M., Nozaki, T., Yagi, T., Horiguchi, S., Fushimi, E., Sugai, Y., Takeda, S., Fukahori, K., Aizawa, K., Tashima, T., Sakurai, K., Kobayashi, T., Matsui, M., Tamada, Y., Yahagi, T., Fukui, A., Takahashi, K., Kikuchi, Y., Akai, K., Kanno, H., Kaneko, J., Suzuki, S., Katayose, D., Onodera, S., Komatsu, S., Chida, M., Iwabuchi, K., Takeuchi, M., Yahagi, H., Takahashi, N., Otsuka, K., Koseki, Y., Morita, M., Ishizuka, T., Onoue, N., Yamaguchi, N., Fujita, H., Katoh, A., Namiuchi, S., Sugie, T., Saji, K., Takii, T., Sugimura, A., Ohashi, J., Tanikawa, T., Kitamukai, O., Matsumoto, Y., Koyama, J., Tomioka, T., Shioiri, H., Ito, Y., Kato, H., Takahashi, C., Kawana, A., Sakata, Y., Ito, K., Nakayama, M., Fukuda, K., Takahashi, J., Miyata, S., Sugimura, K., Sato, K., Nakano, M., Shiroto, T., Tsuburaya, R., Nochioka, K., Yamamoto, H., Aoki, T., Hao, K., Miura, M., Kondo, M., Tatebe, S., Yamamoto, S., Suzuki, H., Nishimiya, K., Yaoita, N., Yamamoto, Y., Toda, S., Minatoya, Y., Takagi, Y., Hasebe, Y., Nihei, T., Hanawa, K., Tadaki, S., Ushigome, R., Yamauchi, T., Tsuji, K., Onose, T., Abe, R., Saga, C., Suenaga, J., Yamada, Y., Kimura, J., Ogino, H., Oikawa, I., Watanabe, S., Saga, M., Washio, M., Nagasawa, K., Nagasawa, S., Kotaka, S., Komatsu, W., Hashimoto, R., Ikeno, Y., Suzuki, T., and Hamada, H.
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Male ,medicine.medical_specialty ,Adrenergic beta-Antagonists ,Tetrazoles ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Kaplan-Meier Estimate ,Medication Adherence ,Clinical Research ,Internal medicine ,medicine ,Clinical endpoint ,Olmesartan ,Humans ,Prospective Studies ,Myocardial infarction ,Prospective cohort study ,Stroke ,Aged ,Heart Failure ,business.industry ,Hazard ratio ,Imidazoles ,Heart Failure/Cardiomyopathy ,medicine.disease ,Treatment Outcome ,Endocrinology ,Blood pressure ,Heart failure ,Chronic Disease ,Hypertension ,Angiotensin II receptor blocker ,Cardiology ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,business ,Angiotensin II Type 1 Receptor Blockers ,medicine.drug - Abstract
We examined whether an additive treatment with an angiotensin receptor blocker, olmesartan, reduces the mortality and morbidity in hypertensive patients with chronic heart failure (CHF) treated with angiotensin-converting enzyme (ACE) inhibitors, β-blockers, or both. In this prospective, randomized, open-label, blinded endpoint study, a total of 1147 hypertensive patients with symptomatic CHF (mean age 66 years, 75% male) were randomized to the addition of olmesartan (n = 578) to baseline therapy vs. control (n = 569). The primary endpoint was a composite of all-cause death, non-fatal acute myocardial infarction, non-fatal stroke, and hospitalization for worsening heart failure. During a median follow-up of 4.4 years, the primary endpoint occurred in 192 patients (33.2%) in the olmesartan group and in 166 patients (29.2%) in the control group [hazard ratio (HR) 1.18; 95% confidence interval (CI), 0.96–1.46, P = 0.112], while renal dysfunction developed more frequently in the olmesartan group (16.8 vs. 10.7%, HR 1.64; 95% CI 1.19–2.26, P = 0.003). Subgroup analysis revealed that addition of olmesartan to combination of ACE inhibitors and β-blockers was associated with increased incidence of the primary endpoint (38.1 vs. 28.2%, HR 1.47; 95% CI 1.11–1.95, P = 0.006), all-cause death (19.4 vs. 13.5%, HR 1.50; 95% CI 1.01–2.23, P = 0.046), and renal dysfunction (21.1 vs. 12.5%, HR 1.85; 95% CI 1.24–2.76, P = 0.003). Additive use of olmesartan did not improve clinical outcomes but worsened renal function in hypertensive CHF patients treated with evidence-based medications. Particularly, the triple combination therapy with olmesartan, ACE inhibitors and β-blockers was associated with increased adverse cardiac events. This study is registered at clinicaltrials.gov-NCT00417222.
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- 2015
17. Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
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Yokogawa H, Kobayashi A, Yamazaki N, Masaki T, and Sugiyama K
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Ophthalmology ,genetic structures ,RE1-994 ,eye diseases - Abstract
Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report surgical therapies for corneal perforations in a tertiary referral hospital.Methods: Thirty-one eyes of 31patients (aged 62.4±18.3years) with surgically treated corneal perforations from January 2002to July 2013were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed.Results: The causes of corneal perforation (n=31) were divided into infectious (n=8, 26%) and noninfectious (n=23, 74%) categories. Infectious causes included fungal ulcer, herpetic stromal necrotizing keratitis, and bacterial ulcer. The causes of noninfectious keratopathy included corneal melting after removal of a metal foreign body, severe dry eye, lagophthalmos, canaliculitis, the oral anticancer drug S-1, keratoconus, rheumatoid arthritis, neurotrophic ulcer, atopic keratoconjunctivitis, and unknown causes. Initial surgical procedures included central large corneal graft (n=17), small corneal graft (n=7), and amniotic membrane transplantation (n=7). In two cases the perforation could not be sealed during the first surgical treatment and required subsequent procedures. All infectious keratitis required central large penetrating keratoplasty to obtain anatomical cure. In contrast, several surgical options were used for the treatment of noninfectious keratitis. After surgical treatment, anatomical cure was obtained in all cases. Mean postoperative best corrected visual acuity was better at 6months (logMAR 1.3) than preoperatively (logMAR 1.8).Conclusion: Surgical therapies for corneal perforations in our hospital included central large lamellar/penetrating keratoplasty, small peripheral patch graft, and amniotic membrane transplantation. All treatments were effective. Corneal perforation due to the oral anticancer drug S-1is newly reported. Keywords: corneal perforation, keratoplasty, amniotic membrane transplantation
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- 2014
18. Endothelial keratoplasty with infant donor tissue
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Kobayashi A, Yokogawa H, Yamazaki N, Masaki T, and Sugiyama K
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Ophthalmology ,genetic structures ,RE1-994 - Abstract
Akira Kobayashi, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Abstract: Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2years). Intraoperative and postoperative complications were recorded. Best corrected visual acuity and donor central endothelial cell density were recorded preoperatively and postoperatively. Infant donor tissue preparation with a microkeratome set at 300µm was successful; the donor tissue was extremely elastic and soft compared with adult tissue. The central endothelial cell density of the infant donor tissue was as high as 4,291 cells/mm2. No complications were observed during donor tissue (8.0mm in diameter) insertion with the double-glide technique (Busin glide with intraocular lens sheet glide) or any of the other procedures. Best corrected visual acuity improved from 1.7logMAR (logarithm of the minimum angle of resolution; 0.02decimal visual acuity) preoperatively to 0.2logMAR (0.6) after 6months and 0.1logMAR (0.8) after 1 year. The central endothelial cell density after 6months was 4,098cells/mm2(representing a 4.5% cell loss from preoperative donor cell measurements), and the central endothelial cell density after 1 year was 4,032cells/mm2(6.0% decrease). Infant donor tissue may be preferably used for DSAEK/nDASEK, since it may not be suitable for penetrating keratoplasty or Descemet membrane endothelial keratoplasty. Keywords: brain death, non-Descemet stripping automated endothelial keratoplasty, infant donor, endothelial keratoplasty
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- 2014
19. In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
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Kobayashi A, Higashide T, Yokogawa H, Yamazaki N, Masaki T, and Sugiyama K
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Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI) with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures). Patients and methods: Two patients (67-year-old male and his 26-year-old son) with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD) (the right eye) and 384 µm oculus sinister (OS) (the left eye) in the father and 430 µm OD and 425 µm OS in the son). In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layer
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- 2014
20. Recent ASDEX Upgrade research in support of ITER and DEMO
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Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, CROCI, GABRIELE, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, GORINI, GIUSEPPE, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, Klingshirn, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, h, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, McCarthy, P, McDermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, NOCENTE, MASSIMO, Nold, B, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, Sun, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, European Commission (EC), Science and Technology of Nuclear Fusion, Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, Gorini, G, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, K, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, H, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, M, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, Nocente, M, Nold, B, M, N, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, S, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, and EUROfusion MST1 Team
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Nuclear and High Energy Physics ,Tokamak ,Cyclotron ,Condensed Matter Physic ,Collisionality ,01 natural sciences ,Resonant magnetic perturbations ,Electron cyclotron resonance ,010305 fluids & plasmas ,law.invention ,Nuclear physics ,ASDEX Upgrade ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,law ,ITER ,0103 physical sciences ,010306 general physics ,Edge-localized mode ,tokamak physic ,DEMO ,nuclear fusion ,Physics ,Divertor ,Condensed Matter Physics ,Tokamak physics ,Nuclear fusion ,tokamak physics - Abstract
Recent experiments on the ASDEX Upgrade tokamak aim at improving the physics base for ITER and DEMO to aid the machine design and prepare efficient operation. Type I edge localized mode (ELM) mitigation using resonant magnetic perturbations (RMPs) has been shown at low pedestal collisionality ( ν ∗ ped < 0 . 4 ) . In contrast to the previous high ν ∗ regime, suppression only occurs in a narrow RMP spectral window, indicating a resonant process, and a concomitant confinement drop is observed due to a reduction of pedestal top density and electron temperature. Strong evidence is found for the ion heat flux to be the decisive element for the L–H power threshold. A physics based scaling of the density at which the minimum P LH occurs indicates that ITER could take advantage of it to initiate H-mode at lower density than that of the final Q = 10 operational point. Core density fluctuation measurements resolved in radius and wave number show that an increase of R/L T e introduced by off-axis electron cyclotron resonance heating (ECRH) mainly increases the large scale fluctuations. The radial variation of the fluctuation level is in agreement with simulations using the GENE code. Fast particles are shown to undergo classical slowing down in the absence of large scale magnetohydrodynamic (MHD) events and for low heating power, but show signs of anomalous radial redistribution at large heating power, consistent with a broadened off-axis neutral beam current drive current profile under these conditions. Neoclassical tearing mode (NTM) suppression experiments using electron cyclotron current drive (ECCD) with feedback controlled deposition have allowed to test several control strategies for ITER, including automated control of (3,2) and (2,1) NTMs during a single discharge. Disruption mitigation studies using massive gas injection (MGI) can show an increased fuelling efficiency with high field side injection, but a saturation of the fuelling efficiency is observed at high injected mass as needed for runaway electron suppression. Large locked modes can significantly decrease the fuelling efficiency and increase the asymmetry of radiated power during MGI mitigation. Concerning power exhaust, the partially detached ITER divertor scenario has been demonstrated at P sep /R = 10 MW m − 1 in ASDEX Upgrade, with a peak time averaged target load around 5MWm − 2 , well consistent with the component limits for ITER. Developing this towards DEMO, full detachment was achieved at P sep /R = 7MWm − 1 and stationary discharges with core radiation fraction of the order of DEMO requirements (70% instead of the 30% needed for ITER) were demonstrated. Finally, it remains difficult to establish the standard ITER Q = 10 scenario at low q 95 = 3 in the all-tungsten (all-W) ASDEX Upgrade due to the observed poor confinement at low β N . This is mainly due to a degraded pedestal performance and hence investigations at shifting the operational point to higher β N by lowering the current have been started. At higher q 95 , pedestal performance can be recovered by seeding N 2 as well as CD 4 , which is interpreted as improved pedestal stability due to the decrease of bootstrap current with increasing Z eff . Concerning advanced scenarios, the upgrade of ECRH power has allowed experiments with central ctr-ECCD to modify the q -profile in improved H-mode scenarios, showing an increase in confinement at still good MHD stability with flat elevated q -profiles at values between 1.5 and 2. European Commission (EUROfusion 633053)
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- 2015
21. The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy
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Kobayashi A, Yokogawa H, Yamazaki N, Masaki T, and Sugiyama K
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Ophthalmology ,genetic structures ,RE1-994 ,eye diseases - Abstract
Akira Kobayashi, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To report the first case of Descemet membrane endothelial keratoplasty (DMEK) for bullous keratopathy (BK) secondary to argon laser iridotomy (ALI).Patient: A 71-year-old woman presented with decreased visual acuity in her right eye due to BK secondary to ALI that was performed 10 years prior.Results: Phacosurgery was performed first, followed by successful DMEK 4 months later. A DMEK shooter was used for donor insertion, which allowed for a stable anterior chamber during donor insertion, even when the anterior chamber was quite shallow. Also, removal of edematous epithelial cells and endoillumination probe-assisted DMEK was quite useful to visualize DMEK graft on the background of the dark brown iris seen in Asian eyes. The patient’s best corrected visual acuity rapidly increased from 20/200 to 25/20 after 1 month, with complete resolution of corneal edema.Conclusion: We reported the first successful DMEK case for BK secondary to ALI. The use of a DMEK shooter for donor insertion and endoillumination assistance to visualize the DMEK graft was a useful technique for BK secondary to ALI. Keywords: argon laser iridotomy, bullous keratopathy, endoillumination, DMEK
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- 2015
22. Descemet’s stripping and non-Descemet’s stripping automated endothelial keratoplasty for microcornea using 6.0 mm donor grafts
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Yokogawa H, Kobayashi A, Yamazaki N, Ueta Y, Hashimoto Y, Tachi N, and Sugiyama K
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Ophthalmology ,sense organs ,RE1-994 ,eye diseases - Abstract
Hideaki Yokogawa,1 Akira Kobayashi,1 Natsuko Yamazaki,1 Yoshiki Ueta,2 Yoshihiro Hashimoto,2 Naoko Tachi,2 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, 2Department of Ophthalmology, Shinseikai Toyama Hospital, Imizu-shi, JapanBackground: The purpose of this paper is to report our experience of Descemet’s stripping and non-Descemet’s stripping automated endothelial keratoplasty (DSAEK/nDSAEK) for microcorneas using 6.0 mm donor grafts.Methods: Three eyes of two patients (a 56-year-old woman and a 59-year-old woman) with microcornea and suffering from bullous keratopathy were treated with either DSAEK or nDSAEK. A small donor graft (6.0 mm) was inserted into the anterior chamber using a double glide (Busin glide and intraocular lens sheet glide) donor insertion technique. Both patients were followed for at least 12 months. Clinical outcomes, including intraoperative and postoperative complications, visual acuity, and endothelial cell density were evaluated.Results: In all three cases (100%), no intraoperative complications were noted. In one case with a flat keratometry value (32.13 D), a partial donor detachment was noted one day postoperatively, but it was reattached by rebubbling. In another case, rejection was noted 8 months postoperatively, but treatment with systemic corticosteroids was successful. A clear cornea remained in all three cases (100%), with best-corrected visual acuity greater than 20/100 (mean 20/50) at 12 months. Mean postoperative endothelial cell counts were 2,603 ± 18 cells/mm2 at 6 months (7.4% decrease from preoperative donor cell counts) and 1,799 ± 556 cells/mm2 at 12 months (36.5% decrease).Conclusion: We report for the first time the successful use of a small donor graft (6.0 mm) for DSAEK/nDSAEK in cases of microcornea. Additional studies using a large number of patients are required to evaluate fully the potential advantages and drawbacks of small diameter donor grafts for microcornea.Keywords: microcornea, Descemet’s stripping, non-Descemet’s stripping, automated endothelial keratoplasty, small donor grafts
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- 2013
23. Overview on plasma operation with a full tungsten wall in ASDEX Upgrade
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Neu, R., Kallenbach, A., Balden, M., Bobkov, V., Coenen, J. W., Drube, R., Dux, R., Greuner, H., Herrmann, A., Hobirk, J., Höhnle, H., Krieger, K., Kocan, M., Lang, P., Lunt, T., Maier, H., Mayer, M., Müller, H. W., Potzel, S., Pütterich, T., Rapp, J., Rohde, V., Ryter, F., Schneider, P. A., Schweinzer, J., Sertoli, M., Stober, J., Suttrop, W., Sugiyama, K., Rooij, G. van, Wischmeier, M., ASDEX Upgrade Team, and ASDEX Upgrade Team
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Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,ASDEX Upgrade ,Chemistry ,Nuclear engineering ,chemistry.chemical_element ,General Materials Science ,Plasma ,Atomic physics ,Tungsten - Abstract
Operation with all tungsten plasma facing components has become routine in ASDEX Upgrade. The conditioning of the device is strongly simplified and short glow discharges are used only on a daily basis. The long term fuel retention was reduced by more than a factor of 5 as demonstrated in gas balance as well as in post mortem analyses. Injecting nitrogen for radiative cooling, discharges with additional heating power up to 23 MW have been achieved, providing good confinement (H98y2=1), divertor power loads around 5 MW m−2 and divertor temperatures below 10 eV. ELM mitigation by pellet ELM pacemaking or magnetic perturbation coils reduces the deposited energy during ELMs, but also keeps the W density at the pedestal low. As a recipe to keep the central W concentration sufficiently low, central (wave) heating is well established and low density H-Modes could be re-established with the newly available ECRH power of up to 4 MW. The ICRH induced W sources could be strongly reduced by applying boron coatings to the poloidal guard limiters.
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- 2013
24. Clinical features of single and repeated globe rupture after penetrating keratoplasty
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Murata N, Yokogawa H, Kobayashi A, Yamazaki N, and Sugiyama K
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Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Noriaki Murata, Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Kazuhisa SugiyamaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanBackground: In this paper, we report our experience of the clinical features of single and repeated globe rupture after penetrating keratoplasty.Methods: We undertook a retrospective analysis of single and repeated globe ruptures following keratoplasty in eight eyes from seven consecutive patients referred to Kanazawa University Hospital over a 10-year period from January 2002 to March 2012. We analyzed their ophthalmic and demographic data, including age at time of globe rupture, incidence, time interval between keratoplasty and globe rupture, cause of rupture, complicated ocular damage, and visual outcome after surgical repair.Results: Five patients (71.4%) experienced a single globe rupture and two patients (28.6%) experienced repeated globe ruptures. Patient age at the time of globe rupture was 75.4 ± 6.8 (range 67–83) years. Four of the patients were men and three were women. During the 10-year study period, the incidence of globe rupture following penetrating keratoplasty was 2.8%. The time interval between penetrating keratoplasty and globe rupture was 101 ± 92 months (range 7 months to 23 years). The most common cause of globe rupture in older patients was a fall (n = 5, 79.8 ± 3.7 years, all older than 67 years). Final best-corrected visual acuity was .20/200 in three eyes (37.5%). In all except one eye, globe rupture involved the graft-host junction; in the remaining eye, the rupture occurred after disruption of the extracapsular cataract extraction wound by blunt trauma.Conclusion: Preventative measures should be taken to avoid single and repeated ocular trauma following penetrating keratoplasty.Keywords: repeated globe ruptures, penetrating keratoplasty, postoperative complications, ocular trauma
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- 2013
25. Intermittent maser flare around the high mass young stellar object G353.273+0.641 II: Detection of a radio and molecular jet
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Motogi, K., Sorai, K., Sugiyama, K., and Honma, M.
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stars: formation ,ISM: jets and outflows ,masers ,stars: early-type - Published
- 2013
26. Transient effects during erosion of WN by deuterium ions studied with the quartz crystal microbalance technique
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Berger, B., Stadlmayr, R., Meisl, G., Cekada, M., Eisenmenger-Sittner, C., Sugiyama, K., Oberkofler, M., Schwarz-Selinger, T., and Aumayr, F.
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Nuclear and High Energy Physics ,Materials science ,Analytical chemistry ,chemistry.chemical_element ,Quartz crystal microbalance ,Tungsten ,01 natural sciences ,Fluence ,010305 fluids & plasmas ,chemistry.chemical_compound ,chemistry ,Deuterium ,Sputtering ,0103 physical sciences ,Crystallite ,Steady state (chemistry) ,010306 general physics ,Instrumentation ,Tungsten nitride - Abstract
Transient effects during erosion of polycrystalline tungsten-nitride (WN) films by mono-energetic deuterium projectiles are studied using a quartz crystal microbalance technique. The evolution of the mass removal rate of a 360 nm thin WN film under 500 eV/D and 1000 eV/D bombardment is investigated at a temperature of 465 K in situ and in real-time as a function of the deuterium fluence. The measurements are performed at a typical flux of 1018 m−2 s−1. A strong dependency of the observed mass change rate on the deuterium fluence is found. The mass loss is initially higher than for pure tungsten (W) and drops with fluence, finally reaching the same steady state value as for pure W sputtering. Steady state surface conditions are obtained at a fluence of about 0.2 × 1023 D/m2 for 500 eV/D and 0.6 × 1023 D/m2 for 1000 eV/D. SDTrimSP simulations indicate a preferential removal of N and a corresponding W enrichment of the surface.
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- 2016
27. Bowman’s layer encystment in cases of persistent Acanthamoeba keratitis
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Yokogawa H, Kobayashi A, Yamazaki N, Ishibashi Y, Oikawa Y, Tokoro M, and Sugiyama K
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Ophthalmology ,RE1-994 ,eye diseases - Abstract
Hideaki Yokogawa,1 Akira Kobayashi,1 Natsuko Yamazaki,1 Yasuhisa Ishibashi,2 Yosaburo Oikawa,3 Masaharu Tokoro,4 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, 2Department of Ophthalmology, East Washinomiya Hospital, Kuki, 3Department of Medical Zoology, Kanazawa Medical University, Kahoku, 4Department of Parasitology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanBackground: The purpose of this study was to report Acanthamoeba encystment in Bowman’s layer in Japanese cases of persistent Acanthamoeba keratitis (AK).Methods: Laser confocal microscopic images of the cornea were obtained in vivo from 18 consecutive eyes from 17 confirmed AK patients. Retrospectively, 14 cases treated over 4 months were categorized as a nonpersistent group and three cases that required prolonged therapy for more than 6 months were categorized as a persistent group. Clinical outcomes based on final best-corrected visual acuity were retrospectively analyzed, and selected confocal images were evaluated qualitatively for abnormal findings.Results: The final best-corrected visual acuity was significantly lower (P < 0.01) for patients in the persistent group compared with that in the nonpersistent group. At the initial visit, in vivo confocal microscopy demonstrated Acanthamoeba cysts exclusively in the epithelial layer in both the nonpersistent group (80%) and the persistent group (100%). At a subsequent follow-up visit, numerous Acanthamoeba cysts were observed in the epithelial cell layer and in Bowman’s layer in all patients with persistent AK, but Acanthamoeba cysts were undetectable in all cases with nonpersistent AK tested.Conclusion: Invasion of cysts into Bowman’s layer was characteristically observed in patients with persistence of AK. This finding suggests that invasion of Acanthamoeba cysts into Bowman’s layer may be a useful predictor for a persistent clinical course.Keywords: Acanthamoeba keratitis, Bowman’s layer, encystment
- Published
- 2012
28. Ex vivo laser confocal microscopy findings of cultured Acanthamoeba trophozoites
- Author
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Yamazaki N, Kobayashi A, Yokogawa H, Ishibashi Y, Oikawa Y, Tokoro M, and Sugiyama K
- Subjects
Ophthalmology ,RE1-994 - Abstract
Natsuko Yamazaki,1 Akira Kobayashi,1 Hideaki Yokogawa,1 Yasuhisa Ishibashi,2 Yosaburo Oikawa,3 Masaharu Tokoro,4 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 2Department of Ophthalmology, East Washinomiya Hospital, Kuki, Japan; 3Department of Medical Zoology, Kanazawa Medical University, Kahoku, Japan; 4Department of Parasitology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: The purpose of the current study was to investigate ex vivo laser confocal microscopic findings of cultured Acanthamoeba trophozoites obtained from Acanthamoeba keratitis patients.Methods: Eight cultured samples of Acanthamoeba trophozoites from eight eyes of seven patients (mean age, 26.9 years; age range, 18–52 years) were used. Seven samples were from corneal scrapings of Acanthamoeba keratitis patients and one sample was from the solution in a soft contact lens case. Ex vivo laser confocal microscopy was performed to qualitatively evaluate the shape and degree of light reflection of the living Acanthamoeba trophozoites.Results: Ex vivo laser confocal microscopy demonstrated highly reflective, high-contrast Acanthamoeba trophozoites with no walls (mean size, 25.4 µm; range, 17.1–58.5 µm). The shapes of the trophozoites were highly pleomorphic, and some showed characteristic acanthopodia by laser confocal microscopy.Conclusion: Ex vivo laser confocal microscopy was effective in demonstrating cultured Acanthamoeba trophozoites of various shapes and sizes. The observations of the current study may be helpful when similar structures are identified under in vivo conditions.Keywords: Acanthamoeba, trophozoite, laser confocal microscopy
- Published
- 2012
29. In vivo laser confocal microscopy findings in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy
- Author
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Kobayashi A, Yokogawa H, and Sugiyama K
- Subjects
Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Akira Kobayashi, Hideaki Yokogawa, Kazuhisa SugiyamaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanBackground: The purpose of this study was to investigate pathological changes of the corneal cell layer in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy by in vivo laser corneal confocal microscopy.Methods: Two patients were evaluated using a cornea-specific in vivo laser scanning confocal microscope (Heidelberg Retina Tomograph 2 Rostock Cornea Module, HRT 2-RCM). The affected corneal areas of both patients were examined. Image analysis was performed to identify corneal epithelial and stromal deposits correlated with this dystrophy.Results: Variously shaped (linear, multilaminar, curvilinear, ring-shape, geographic) highly reflective materials were observed in the “map” area, mainly in the basal epithelial cell layer. In “fingerprint” lesions, multiple linear and curvilinear hyporeflective lines were observed. Additionally, in the affected corneas, infiltration of possible Langerhans cells and other inflammatory cells was observed as highly reflective Langerhans cell-like or dot images. Finally, needle-shaped materials were observed in one patient.Conclusion: HRT 2-RCM laser confocal microscopy is capable of identifying corneal microstructural changes related to map-dot-fingerprint corneal dystrophy in vivo. The technique may be useful in elucidating the pathogenesis and natural course of map-dot-fingerprint corneal dystrophy and other similar basement membrane abnormalities.Keywords: cornea, confocal microscopy, map-dot-fingerprint dystrophy, epithelial basement membrane dystrophy, Heidelberg Retina Tomograph 2 Rostock Cornea Module (HRT 2-RCM)
- Published
- 2012
30. Localized vitreous adhesion to the retina after ocular contusion with a baseball
- Author
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Kimura M, Nishimura A, and Sugiyama K
- Subjects
Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Masayo Kimura, Akira Nishimura, Kazuhisa SugiyamaDepartment of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report a series of five cases of vitreous adhesions after blunt trauma caused by a baseball strike.Methods: The medical records of patients with ocular contusion after being struck by a baseball, who had undergone pars plana vitrectomy, were reviewed. An aqueous suspension of triamcinolone acetonide was used intraoperatively to facilitate visualization of the vitreous.Results: Five eyes were reviewed in this study. There were two cases of retinal detachment, two cases of traumatic macular hole, and one case of retinal detachment due to traumatic macular hole. Despite the surgical creation of posterior vitreous detachment, if not already present, the thin layer of localized vitreous adhesion to the retinal necrotic area with/without retinal hole was found between the major vascular arcades and the equator in all cases. The thin layer of the vitreous was removed with a vitreous cutter and diamond-dusted membrane scraper, but complete removal was impossible.Conclusions: A thin layer of localized vitreous adhesion at the area of retinal degeneration was observed in eyes following ocular contusion.Keywords: localized, vitreous adhesion, triamcinolone acetonide, ocular contusion, pars plana vitrectomy
- Published
- 2012
31. Retinotomy with retinal turnover to remove subretinal membranes under direct visualization for proliferative vitreoretinopathy
- Author
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Kimura M, Nishimura A, Saito Y, Ikeda H, and Sugiyama K
- Subjects
Ophthalmology ,genetic structures ,sense organs ,RE1-994 ,eye diseases - Abstract
Masayo Kimura,1 Akira Nishimura,1 Yoshiaki Saito,1 Hiroko Ikeda,2 Kazuhisa Sugiyama11Department of Ophthalmology and Visual Science, 2Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: The purpose of the study was to report the outcomes for cases of proliferative vitreoretinopathy (PVR) that received retinotomy and removal of subretinal proliferative tissue under direct visualization using retinal turnover.Methods: Nineteen eyes with posterior and/or anterior grade C1–12 PVR that had undergone retinotomy and retinal turnover were reviewed. Main outcomes included the retinal reattachment rate, final best-corrected visual acuity (BCVA), postoperative intraocular pressure, extent of retinotomy, and complications.Results: Final retinal reattachment rates with silicone oil tamponade were 100%. The mean logarithm of the minimal angle of resolution (logMAR) BCVA was significantly improved (P = 0.001). Positive correlation was found between the extent of retinotomy and both preoperative logMAR BCVA (r = 0.663, P = 0.002) and postoperative logMAR BCVA (r = 0.619, P = 0.005). There was no correlation between the extent of retinotomy and the change in preoperative and postoperative logMAR BCVA (r = –0.267, P = 0.268). Negative correlation was found between preoperative logMAR BCVA and the change in logMAR BCVA (r = –0.587, P = 0.008). There was no correlation between the extent of retinotomy and the intraocular pressure at the final visit (r = –0.316, P = 0.188). Corneal decompensation due to silicone oil in the anterior chamber occurred in one eye.Conclusion: Removal of subretinal proliferative tissue with retinal turnover seems to be an effective procedure.Keywords: proliferative vitreoretinopathy, retinotomy, retinal turnover, subretinal proliferative tissue, under direct visualization
- Published
- 2012
32. Synthesis of non-equilibrium phases in immiscible metals mechanically mixed by high pressure torsion
- Author
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Miyazaki, T., Terada, Daisuke, Miyajima, Yoji, Suryanarayana, C., Murao, R., Yokoyama, Y., Sugiyama, K., Umemoto, M., Todaka, Y., and Tsuji, Nobuhiro
- Subjects
Materials science ,Mechanical Engineering ,Metallurgy ,Torsion (mechanics) ,Thermodynamics ,zirconium ,system ,Atomic units ,arb ,amorphization ,Mechanics of Materials ,High pressure ,Solid mechanics ,General Materials Science ,Single phase - Abstract
The structural changes in mechanically mixed metals of immiscible combinations of elements caused by bulk mechanical alloying (MA) through the use of high pressure torsion (HPT) were investigated in Ag–Ni and Nb–Zr systems. There was no alloying between Ag and Ni on atomic scale even after 100 rotations of HPT. On the other hand, the β-Zr phase started to appear after HPT 2 rotations in the Nb–Zr system, even though β-Zr is a high temperature phase. Further, Nb and Zr were completely mixed to form a bcc structured single phase after HPT 100 rotations. The sequence of alloying in the Nb–Zr system during HPT was discussed. These results clearly suggest that non-equilibrium phases can form in the Nb–Zr system by bulk MA by the use of HPT.
- Published
- 2011
33. Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma
- Author
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Murakami, K., Meguro, A., Ota, M., Shiota, T., Nomura, N., Kashiwagi, K., Mabuchi, F., Iijima, H., Kawase, K., Yamamoto, T., Makoto Nakamura, Negi, A., Sagara, T., Nishida, T., Inatani, M., Tanihara, H., Aihara, M., Araie, M., Fukuchi, T., Abe, H., Higashide, T., Sugiyama, K., Kanamoto, T., Kiuchi, Y., Iwase, A., Ohno, S., Inoko, H., and Mizuki, N.
- Subjects
Male ,genetic structures ,Suppressor of Cytokine Signaling Proteins ,Middle Aged ,Polymorphism, Single Nucleotide ,eye diseases ,Phenotype ,Asian People ,Gene Frequency ,Genetic Loci ,Case-Control Studies ,Humans ,Female ,Low Tension Glaucoma ,Eye Proteins ,Research Article ,Microsatellite Repeats - Abstract
Purpose To investigate whether the GLC1F locus is associated with normal tension glaucoma (NTG) in Japanese patients. Methods We recruited 242 unrelated Japanese subjects, including, 141 NTG patients and 101 healthy controls. The patients exhibiting a comparatively early onset were selected as they suggest that genetic factors may show stronger involvement. Genotyping and assessment of allelic diversity was performed on 11 highly polymorphic microsatellite markers in and around the GLC1F locus. Results Individuals carrying the 163 allele of D7S1277i had a statistically significant increased risk of NTG (p=0.0013, pc=0.016, OR=2.47, 95%CI=1.42–4.30). None of the other markers identified significant loci (pc>0.05) after Bonferroni’s correction. Conclusions These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of NTG.
- Published
- 2010
34. Optical frequency measurement using chirped-mirror-dispersion-controlled mode-locked TiAl2O3 laser
- Author
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Sugiyama, K, Hong, FL, Ishikawa, J, Onae, A, Ikegami, T, Slyusarev, SN, Minoshima, K, Matsumoto, H, Inaba, H, Knight, JC, Wadsworth, WJ, and Russell, PSJ
- Subjects
optical frequency measurement ,octave spanning ,photonic-crystal fiber ,chirped mirror ,carrier-envelope offset frequency ,frequency stabilization ,mode-locked laser ,carrier-envelope offset phase ,optical frequency comb ,optical frequency standard - Published
- 2006
35. A sliding technique to load thin endothelial donor lamella onto Busin glide for Descemet-stripping automated endothelial keratoplasty
- Author
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Kobayashi A, Yokogawa H, and Sugiyama K
- Subjects
Ophthalmology ,RE1-994 ,human activities - Abstract
Akira Kobayashi, Hideaki Yokogawa, Kazuhisa SugiyamaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanAbstract: We describe a modified technique for loading donor corneal endothelial lamella onto a Busin glide® without causing wrinkles, as part of the procedure of Descemet-stripping automated endothelial keratoplasty. Briefly, after punching out a composite of the donor-endothelial lamella and a microkeratome-dissected cap, several drops of dispersive ophthalmic viscosurgical device are placed onto the endothelial surface. The Busin glide surface is then wetted with several drops of balanced salt solution. After the composite is transferred onto the Busin glide, hydrodissection of the potential space between the donor-endothelial lamella and the microkeratome-dissected cap is carefully performed to enable smooth detachment of these two lamellae. Whereas simply dragging the donor-endothelial lamella directly onto the glide can cause wrinkling or folding of the donor lamella, this technique enables smooth detachment of the composite without wrinkle or fold formation, and results in less endothelial cell damage.Keywords: DSAEK, Busin glide, endothelial keratoplasty
- Published
- 2012
36. Medial blepharosynechioplasty: a new surgical concept for severe dry eye
- Author
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Sasaki T, Ota T, Ookura Y, and Sugiyama K
- Subjects
Ophthalmology ,RE1-994 - Abstract
Tsugihisa Sasaki,1,2 Taeko Ota,3 Youko Ookura,4 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University School of Medicine, Kanazawa, Ishikawa; 2Department of Ophthalmology, Fukui Prefectural Hospital, Fukui; 3Department of Ophthalmology, Tonami General Hospital, Tonami-city, Toyama; 4Department of Ophthamology, Saiseikai Kanazawa Hospital, Kanazawa, Ishikawa, JapanBackground: The purpose of this work was to report on the performance of medial blepharosynechioplasty (MBSP), a newly devised technique for treating severe dry eye.Methods: In this retrospective, nonrandomized clinical trial, three cases with severe dry eye (Sjögren’s syndrome) associated with repeated punctal plug loss were treated using MBSP to create a synechia between the upper and lower lid medial borders of the puncta to suppress the lacrimal pump.Results: Postoperative follow-up showed improvement in the corneal condition in all three cases that persisted for 12–35 months. None of the patients had visual impairment.Conclusion: MBSP is a promising treatment for severe dry eye and merits further study.Keywords: dry eye, lacrimal pump suppression, medial blepharosynechioplasty
- Published
- 2012
37. Rehabilitation for paraplegia caused by neuromyelitis optica: a case report
- Author
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Sugiyama K, Kondo T, Shin-ichi Izumi, and Masaaki Sato
- Subjects
Adult ,medicine.medical_specialty ,Flaccid paralysis ,medicine.medical_treatment ,Lesion ,Activities of Daily Living ,medicine ,Humans ,Spinal cord injury ,Spinal Cord Injuries ,Paraplegia ,Neuromyelitis optica ,Rehabilitation ,business.industry ,Neuromyelitis Optica ,General Medicine ,Recovery of Function ,medicine.disease ,Spinal cord ,Trunk ,Magnetic Resonance Imaging ,nervous system diseases ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Neurology ,Spinal Cord ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Single case report. We present a case of paraplegia due to neuromyelitis optica (NMO) with poor rehabilitation outcome. University hospital, Japan. A 27-year-old woman with NMO presented with T5 paraplegia of ASIA impairment scale grade A. Spinal cord magnetic resonance imaging revealed a lesion spanning C3 to L1 level. After acute phase treatment, flaccid paraplegia below T5 and a T2-weighted hyperintense lesion from T6 to T10 level remained. Rehabilitation aimed at independence of activities of daily living with wheelchair assistance, including transfer activity, was provided for 19 months. However, flaccid paralysis of the trunk and limbs persisted, and safe independent transfer was not achieved. Spinal lesions spanning many vertebral segments, a characteristic of NMO, can cause extensive flaccid paralysis of the trunk and limbs. Rehabilitation may achieve poorer functional recovery than that for spinal cord injury.
- Published
- 2014
38. The Design and Styling of Technology-based Innovation. Theory and Practical cases
- Author
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Eggink, Wouter, Reinders, Angelina H.M.E., Takatera, Sugiyama, K., Kobayashi, A., Shiraishi, M, Kobayasi, N., and Faculty of Engineering Technology
- Subjects
METIS-301375 ,IR-90952 - Published
- 2013
39. Development of laser-induced breakdown spectroscopy for analyzing deposited layers in ITER
- Author
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Juuso Karhunen, Antti Hakola, Jari Likonen, Lissovski, A., Paris, P., Laan, M., Lungu, C. P., and Sugiyama, K.
- Published
- 2013
40. Angiotensin II (AII) induced hypertension chemotherapy (IHC) for unresectable gastric cancer: With reference to resection after down staging
- Author
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Masahiko Hoshi, Ishizuka K, Haruhiko Sato, Masanobu Urushiyama, and Sugiyama K
- Subjects
Adult ,Male ,medicine.medical_specialty ,Mitomycin ,medicine.medical_treatment ,Blood Pressure ,Gastroenterology ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Stage (cooking) ,Aged ,Neoplasm Staging ,Chemotherapy ,business.industry ,Angiotensin II ,Stomach ,Remission Induction ,Cancer ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Surgery ,Regimen ,Blood pressure ,medicine.anatomical_structure ,Doxorubicin ,Immunohistochemistry ,Female ,Fluorouracil ,business - Abstract
Angiotensin II induced hypertension chemotherapy (IHC) is a drug delivery system for augmentation of anti-cancer effects on the experimental basis of the functional difference of microcirculation between tumor and normal tissue. Blood flow in tumor tissue increased selectively when the blood pressure was elevated by the infusion of angiotensin II. Two randomized controlled trials (RCT) for advanced gastric cancer using AFM regimen; a combination of adriamycin (ADM), 5-fluorouracil (5-FU), and mitomycin (MMC), showed increased response rate by IHC (response rate: IHC/non-IHC; 42.9% vs 10.5% in RCT-1, and 31.3% vs 6.7% in RCT-2, respectively). Toxicities were not different statistically between groups. In phase II for stage IVB gastric cancer patients (the criteria according to the General Rules of the Gastric Cancer Study of Japanese Research Society for Gastric Cancer), 5 complete response (CR) and 10 partial response (PR) (58%) were observed out of 26 unresectable cases without prior chemotherapy. Moreover, 5 of 15 responders could received curative gastrectomy and obtained conclusive down staging (19%). Here we discuss the role of enhancement of drug delivery for cancer chemotherapy on the basis of a series of clinical and experimental evidences.
- Published
- 1995
41. Transsphenoidal surgery for pituitary adenoma and craniopharyngioma with endoscope assistance, special emphasis on tips and how to avoid complications
- Author
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Kurisu, K, Tominaga, A, Kinoshita, Y, Usui, S, Sakoguchi, T, and Sugiyama, K
- Subjects
ddc: 610 ,microscope ,endoscope ,610 Medical sciences ,Medicine ,TSS - Abstract
Objective: We have no objection to the doctrine that micro-neurosurgery under the operating microscope is crucial to the basis of neurosurgery. But in recent years, endoscopic micro-neurosurgery has been spreading dramatically and very speedily. We have also steadily expanded the indication for the [for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)
- Published
- 2012
- Full Text
- View/download PDF
42. Erosion and deposition studies at JET and ASDEX upgrade
- Author
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Mayer, M., Krat, S., Hakola, Antti, Coad, Paul, Gasparyan, Y., Koivuranta, Seppo, Likonen, Jari, Neu, R., Pisarev, A., Rohde, V., Sugiyama, K., and Widdowson, A.
- Published
- 2012
43. STUDIES ON SURGICAL REMOVAL OF LOCALLY RECURENT RECTAL CANCER
- Author
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Sugiyama K, Akio Yamaguchi, Takahiro Sato, Yutaka Yonemura, Masahiro Kanno, Itsuo Miyazaki, Genichi Nishimura, Koichi Miwa, and Takashi Fujimura
- Subjects
medicine.medical_specialty ,business.industry ,Colorectal cancer ,Surgical removal ,Medicine ,business ,medicine.disease ,Surgery - Published
- 1994
44. Continuous hyperthermic peritoneal perfusion for the prevention of peritoneal recurrence of gastric cancer: Randomized controlled study
- Author
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Yasuo Hirono, Hisashi Matsumoto, Sugiyama K, Takashi Fujimura, Itasu Ninomiya, Itsuo Miyazaki, Hiroyuki Takamura, Yutaka Yonemura, Hiroyuki Sahara, Genichi Nishimura, Keiichi Muraoka, Kouichiro Tsugawa, and Kouichi Miwa
- Subjects
Male ,medicine.medical_specialty ,Mitomycin ,medicine.medical_treatment ,Urology ,Stomach Neoplasms ,medicine ,Humans ,Continuous hyperthermic peritoneal perfusion ,Saline ,Peritoneal Neoplasms ,Cisplatin ,Chemotherapy ,business.industry ,Stomach ,Mitomycin C ,Temperature ,Middle Aged ,Perfusion ,medicine.anatomical_structure ,Anesthesia ,Female ,Surgery ,business ,Abdominal surgery ,medicine.drug - Abstract
We performed continuous hyperthermic peritoneal perfusion (CHPP) or continuous normothermic peritoneal perfusion (CNPP) combined with cisplatin (CDDP) 300 mg/kg and mitomycin C (MMC) 30 mg/kg in an attempt to prevent peritoneal recurrence after surgery for gastric cancer. Twenty-two patients were treated with perfusion using about 10 liters of saline heated to 41 degrees to 42 degrees C (CNPP group); 18 patients were treated with saline heated to 37 degrees to 38 degrees C (CNPP group); and 18 patients underwent only gastric surgery without perfusion (control group) in a randomized control study. There were two deaths (9%) due to peritoneal recurrence in the CHPP group, four (22%) in the CNPP group, and four (22%) in the control group. The 1-, 2-, and 3-year survival rates were 95%, 89%, and 68%, in the CHPP group; 81%, 75%, and 51%, in the CNPP group; and 43%, 23%, and 23%, in the control group, respectively. There was a significant difference between the three survival curves by the log-rank test (p < 0.01). This difference showed that CNPP and CHPP are both effective procedures for preventing peritoneal recurrence. The maximum concentrations in the perfusate of total and free CDDP with 300 mg administration were 12.2 and 10.1 micrograms/ml, respectively, at the end of the perfusion, and the maximum concentrations of total and free CDDP in plasma were 2.1 and 1.0 micrograms/ml, respectively. The maximum concentrations of MMC in perfusate and plasma with 30 mg administration were 1.00 and 0.05 micrograms/ml, respectively, which are intraperitoneally cytotoxic but systemically safe concentrations.
- Published
- 1994
45. Mineralogy and crystallography of vein metals in the Almahata Sitta ureilite
- Author
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Mikouchi, T., A. Goodrich, C., Hoffmann, V., Satake, W., Kaliwoda, M., Hochleitner, R., M. Gigler, A., Sugiyama, K., and E. Zolensky, M.
- Abstract
第2回極域科学シンポジウム/第34回南極隕石シンポジウム 11月18日(金) 国立国語研究所 2階講堂
- Published
- 2011
46. Risk factors for infection in patients with remitted rheumatic diseases treated with glucocorticoids
- Author
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Matsumoto, Y., Ken-ei Sada, Takano, M., Toyota, N., Yamanaka, R., Sugiyama, K., Wakabayashi, H., Kawabata, T., Otsuka, F., and Makino, H.
- Subjects
interstitial pneumonia ,Adult ,Male ,Remission Induction ,Middle Aged ,Infections ,infection ,Medical Records ,Risk Factors ,Rheumatic Diseases ,Humans ,Female ,rheumatic disease ,Glucocorticoids ,Immunosuppressive Agents ,Aged ,Proportional Hazards Models ,Retrospective Studies - Abstract
It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age ≧ 65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level ≧ 2.0 mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR=4.50, 95%CI=1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids.
- Published
- 2011
47. Tough Hypoeutectic Zr-Based Bulk Metallic Glasses
- Author
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Yokoyama, Y., Tokunaga, H., Yavari, A.R., Kawamata, T., Yamasaki, T., Fujita, K., Sugiyama, K., Liaw, P.K., Inoue, A., WPI Advanced Institute for Materials Research (WPI-AIMR), Tohoku University [Sendai], Dept Mech. Engn. Ube Natl Coll. Technol. Yamaguchi, Ube Natl Coll. Technol., Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Hyogo, Univ Tennessee, Dept Mat Sci & Engn, and The University of Tennessee [Knoxville]
- Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry - Abstract
International audience; Significant softening of Zr-based bulk metallic glasses (BMGs) can be seen in a hypoeutectic Zr-enriched composition, which brings about very high toughness (for the Zr(55)Cu(35)Al(10) and Zr(60)Cu(30)Al(10) BMGs) and tensile plasticity at room temperature (for the Zr(70)Ni(16)Cu(6)Al(8) BMG). The unique features of such BMGs include the formation of multiple shear bands and harmonic alternating movements that can immediately accommodate concentrated stresses and avoid accidental catastrophic fracture.
- Published
- 2011
48. Long-term evolution of tungsten surfaces in ASDEX Upgrade
- Author
-
Mayer, M., Balden, M., Fortuna-Zalesna, E., Hakola, Antti, Kurzydlowski, K.J., Lindig, S., Neu, R., Pisarek, M., Rasinski, M., Rozniatowski, K., Schmid, K., and Sugiyama, K.
- Published
- 2011
49. Erosion and re-deposition of W and Ni in the divertor and midplane regions of ASDEX Upgrade
- Author
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Hakola, Antti, Aho-Mantila, Leena, Airila, Markus, Koivuranta, Seppo, Krieger, K., Likonen, Jari, Lindholm, V., Matikainen, Mikko, Mayer, M., Neu, R., Rohde, V., and Sugiyama, K.
- Published
- 2011
50. Global transport of light elements boron and carbon in the full-W ASDEX Upgrade
- Author
-
Hakola, A., Likonen, J., Koivuranta, S., Krieger, K., Mayer, M., Neu, R., Rohde, V., Sugiyama, K., ASDEX Upgrade Team, and ASDEX Upgrade Team
- Subjects
Nuclear and High Energy Physics ,Materials science ,Divertor ,Analytical chemistry ,chemistry.chemical_element ,Tungsten ,Nuclear Energy and Engineering ,chemistry ,ASDEX Upgrade ,Erosion ,General Materials Science ,Graphite ,Boron ,Carbon ,Deposition (chemistry) ,Nuclear chemistry - Abstract
Transport of carbon and boron has been investigated in the full-W ASDEX Upgrade after experimental campaigns with (2008) and without (2007) boronizations. For this purpose, poloidal deposition profiles of the two elements on tungsten and graphite regions of lower-divertor tiles have been determined. Carbon is mainly deposited in the inner divertor – 80–90% of the determined 12C and 13C inventories on W – while boron shows a much more symmetric deposition profile. In the unboronized machine, the boron inventories are a factor of 10 smaller than in the boronized case and result from residual boron atoms left in the torus prior to the 2007 campaign. Both carbon and boron are deposited more efficiently and/or show less erosion on graphite than on tungsten, particularly in the outer divertor. For 13C, the difference is 10–100 in favor of graphite. This is most probably caused by a higher re-erosion from tungsten surfaces.
- Published
- 2011
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