1. Gray and white matter abnormalities in treated HIV-disease and their relationship to cognitive function
- Author
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Underwood, Jonathan, Cole, James H., Caan, Matthan, de Francesco, Davide, Leech, Robert, van Zoest, Rosan A., Su, Tanja, Geurtsen, Gert J., Schmand, Ben A., Portegies, Peter, Prins, Maria, Wit, Ferdinand W. N. M., Sabin, Caroline A., Majoie, Charles, Reiss, Peter, Winston, Alan, Sharp, David J., Radiology and Nuclear Medicine, AII - Infectious diseases, APH - Aging & Later Life, Graduate School, Other departments, APH - Mental Health, Medical Psychology, AII - Amsterdam institute for Infection and Immunity, AMS - Amsterdam Movement Sciences, APH - Global Health, Infectious diseases, Global Health, ACS - Amsterdam Cardiovascular Sciences, ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, and ACS - Diabetes & metabolism
- Abstract
Long-term comorbidities such as cognitive impairment remain prevalent in otherwise effectively treated people-living-with-HIV. We investigate the relationship between cognitive impairment and brain structure in successfully treated patients using multi-modal neuroimaging from the Co-morBidity in Relation to AIDS (COBRA) cohort. Cognitive function, brain tissue volumes and white matter microstructure were assessed in 134 HIV-positive patients and 79 controls. All patients had suppressed plasma HIV RNA at cohort entry. In addition to comprehensive voxelwise analyses of volumetric and diffusion tensor imaging, we used an unsupervised machine learning approach to combine cognitive, diffusion and volumetric data, taking advantage of the complementary information they provide. Compared to the highly comparable control group, cognitive function was impaired in four out of the six cognitive domains tested (median global T-scores: 50.8 vs. 54.2, p
- Published
- 2017