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1. Multiple Coulomb Scattering of muons in Lithium Hydride

Author

Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y.P., Tang, J.Y., Li, Z.H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C.K., Filthaut, F., Fedorov, M., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T.W., Brown, C., Courthold, M., Govans, J., Hills, M., Lagrange, J.-B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J.C., Soler, F.J.P., Gamet, R., Cooke, P., Blackmore, V.J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P.B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M.A., Cobb, J.H., Booth, C.N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P.J., Wilbur, S., Chatzitheodoridis, G.T., Dick, A.J., Ronald, K., Whyte, C.G., Young, A.R., Boyd, S., Greis, J.R., Greishring, J.R., Lord, T., Pidcott, C., Taylor, I., Ellis, M., Gardener, R.B.S., Kyberd, P., Nebrensky, J.J., Palmer, M., Witte, H., Adey, D., Bross, A.D., Bowring, D., Hanlet, P., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Freemire, B., Kaplan, D.M., Mohayai, T.A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L.M., Sanders, D.A., Summers, D.J., Coney, L.R., Hanson, G.G., and Heidt, C.

Subjects
polarization in interactions & scattering, Physics - Instrumentation and Detectors, Astronomy, muons, beam optics transport, neutrinos, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), single-particle dynamics, particles & fields, High Energy Physics - Experiment, lattices in beam optics, High Energy Physics - Experiment (hep-ex), accelerators & beams, Detectors and Experimental Techniques, beam code development & simulation techniques, Particle Physics - Experiment
Abstract

Multiple Coulomb Scattering (MCS) is a well known phenomenon occurring when charged particles traverse materials. Measurements of muons traversing low $Z$ materials made in the MuScat experiment showed that theoretical models and simulation codes, such as GEANT4 (v7.0), over-estimated the scattering. The Muon Ionization Cooling Experiment (MICE) measured the cooling of a muon beam traversing a liquid hydrogen or lithium hydride (LiH) energy absorber as part of a programme to develop muon accelerator facilities, such as a Neutrino Factory or a Muon Collider. The energy loss and MCS that occur in the absorber material are competing effects that alter the performance of the cooling channel. Therefore measurements of MCS are required in order to validate the simulations used to predict the cooling performance in future accelerator facilities. We report measurements made in the MICE apparatus of MCS using a LiH absorber and muons within the momentum range 160 to 245 MeV/c. The measured RMS scattering width is about 9% smaller than that predicted by the approximate formula proposed by the Particle Data Group. Data at 172, 200 and 240 MeV/c are compared to the GEANT4 (v9.6) default scattering model. These measurements show agreement with this more recent GEANT4 (v9.6) version over the range of incident muon momenta., Comment: 20 pages, 14 figures, journal

Published
2022
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2. Demonstration of cooling by the Muon Ionization Cooling Experiment

Author

Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y.P., Tang, J.Y., Li, Z.H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C.K., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T.W., Brown, C., Courthold, M., Govans, J., Hills, M., Lagrange, J.-B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J.C., Soler, F.J.P., Gamet, R., Cooke, P., Blackmore, V.J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P.B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M.A., Cobb, J.H., Booth, C.N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P.J., Wilbur, S., Chatzitheodoridis, G.T., Dick, A.J., Ronald, K., Whyte, C.G., Young, A.R., Boyd, S., Greis, J.R., Lord, T., Pidcott, C., Taylor, I., Ellis, M., Gardener, R.B.S., Kyberd, P., Nebrensky, J.J., Palmer, M., Witte, H., Adey, D., Bross, A.D., Bowring, D., Hanlet, P., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Freemire, B., Kaplan, D.M., Mohayai, T.A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L.M., Sanders, D.A., Summers, D.J., Coney, L.R., Hanson, G.G., Heidt, C., Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y. P., Tang, J. Y., Li, Z. H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C. K., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Boyd, S., Greis, J. R., Lord, T., Pidcott, C., Taylor, I., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T. W., Brown, C., Courthold, M., Govans, J., Hills, M., Lagrange, J. -B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J. C., Soler, F. J. P., Chatzitheodoridis, G. T., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Gamet, R., Cooke, P., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P. B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P. J., Wilbur, S., Ellis, M., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Demello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Palmer, M., Witte, H., Adey, D., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Coney, L. R., Hanson, G. G., Heidt, C., Particle Physics and Astronomy Research Council (PPARC), The Royal Society, Commission of the European Communities, Council for the Central Laboratory of the Research Councils' (CCLRC), Science and Technology Facilities Council (STFC), and Imperial College Trust

Subjects
Physics::Instrumentation and Detectors, General Science & Technology, Library science, 01 natural sciences, 7. Clean energy, Article, PHYSICS, DESIGN, 0103 physical sciences, media_common.cataloged_instance, Ionization cooling, High Energy Physics, Physics::Atomic Physics, European union, Experimental nuclear physics, 010306 general physics, QC, media_common, physics.acc-ph, Multidisciplinary, Science & Technology, 010308 nuclear & particles physics, hep-ex, MICE collaboration, Chinese academy of sciences, Accelerators and Storage Rings, Mechanical engineering, Multidisciplinary Sciences, Experimental High Energy Physics, Science & Technology - Other Topics, Physics::Accelerator Physics, Christian ministry, High Energy Physics::Experiment, Experimental particle physics, Particle Physics - Experiment
Abstract

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such ‘tertiary’ beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton–antilepton collisions at extremely high energies and provide well characterized neutrino beams1–6. Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness7,8. Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect9–11. The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced footprint6., Ionization cooling, a technique that delivers high-brightness muon beams for the study of phenomena at energy scales beyond those of the Large Hadron Collider, is demonstrated by the Muon Ionization Cooling Experiment.

Published
2020

3. Performance of the MICE diagnostic system

Author

The MICE collaboration, Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y. P., Tang, J. Y., Li, Z. H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C. K., Filthaut, F., Fedorov, M., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T. W., Brown, C., Courthold, M., Govans, J., Hills, M., Lagrange, J. -B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J. C., Soler, F. J. P., Gamet, R., Cooke, P., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P. B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P. J., Wilbur, S., Chatzitheodoridis, G. T., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Boyd, S., Greis, J. R., Lord, T., Pidcott, C., Taylor, I., Ellis, M., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Palmer, M., Witte, H., Adey, D., Bross, A. D., Bowring, D., Hanlet, P., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Freemire, B., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Coney, L. R., Hanson, G. G., Heidt, C., and Science and Technology Facilities Council (STFC)

Subjects
Accelerator Physics (physics.acc-ph), Physics::Instrumentation and Detectors, FOS: Physical sciences, 01 natural sciences, 09 Engineering, Nuclear physics, 0103 physical sciences, Ionization cooling, 010306 general physics, Instrumentation, Mathematical Physics, Liquid hydrogen, QC, physics.acc-ph, Physics, 02 Physical Sciences, Muon, 010308 nuclear & particles physics, Nuclear & Particles Physics, Accelerators and Storage Rings, Muon collider, Physics::Accelerator Physics, Neutrino Factory, High Energy Physics::Experiment, Physics - Accelerator Physics, International Muon Ionization Cooling Experiment, Neutrino, Beam (structure)
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterised neutrino beams of a neutrino factory and for multi-TeV lepton-antilepton collisions at a muon collider. The international Muon Ionization Cooling Experiment (MICE) has demonstrated the principle of ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. This paper documents the performance of the detectors used in MICE to measure the muon-beam parameters, and the physical properties of the liquid hydrogen energy absorber during running., 27 pages, 18 figures

Published
2021

4. First particle-by-particle measurement of emittance in the Muon Ionization Cooling Experiment

Author

The MICE Collaboration, Adams, D., Adey, D., Asfandiyarov, R., Barber, G., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V., Blondel, A., Boehm, J., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bross, A. D., Brown, C., Coney, L., Charnley, G., Chatzitheodoridis, G. T., Chignoli, F., Chung, M., Cline, D., Cobb, J. H., Colling, D., Collomb, N., Cooke, P., Courthold, M., Cremaldi, L. M., DeMello, A., Dick, A. J., Dobbs, A., Dornan, P., Drielsma, F., Dumbell, K., Ellis, M., Filthaut, F., Franchini, P., Freemire, B., Gallagher, A., Gamet, R., Gardener, R. B. S., Gourlay, S., Grant, A., Greis, J. R., Griffiths, S., Hanlet, P., Hanson, G. G., Hartnett, T., Heidt, C., Hodgson, P., Hunt, C., Ishimoto, S., Jokovic, D., Jurj, P. B., Kaplan, D. M., Karadzhov, Y., Klier, A., Kuno, Y., Kurup, A., Kyberd, P., Lagrange, J-B., Langlands, J., Lau, W., Li, D., Li, Z., Liu, A., Long, K., Lord, T., Macwaters, C., Maletic, D., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Mohayai, T. A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nugent, J. C., Oates, A., Orestano, D., Overton, E., Owens, P., Palladino, V., Palmer, M., Pasternak, J., Pec, V., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ricciardi, S., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Sakamoto, H., Sanders, D. A., Sato, A., Savic, M., Snopok, P., Smith, P. J., Soler, F. J. P., Song, Y., Stanley, T., Stokes, G., Suezaki, V., Summers, D. J., Sung, C. K., Tang, J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tucker, M., Uchida, M. A., Virostek, S., Vankova-Kirilova, G., Warburton, P., Wilbur, S., Wilson, A., Witte, H., White, C., Whyte, C. G., Yang, X., Young, A. R., Zisman, M., Adams, D., Adey, D., Asfandiyarov, R., Barber, G., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V., Blondel, A., Boehm, J., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bross, A. D., Brown, C., Charnley, G., Chatzitheodoridis, G. T., Chignoli, F., Chung, M., Cline, D., Cobb, J. H., Colling, D., Collomb, N., Cooke, P., Courthold, M., Cremaldi, L. M., Demello, A., Dick, A. J., Dobbs, A., Dornan, P., Drielsma, F., Dumbell, K., Ellis, M., Filthaut, F., Franchini, P., Freemire, B., Gallagher, A., Gamet, R., Gardener, R. B. S., Gourlay, S., Grant, A., Greis, J. R., Griffiths, S., Hanlet, P., Hanson, G. G., Hartnett, T., Heidt, C., Hodgson, P., Hunt, C., Ishimoto, S., Jokovic, D., Jurj, P. B., Kaplan, D. M., Karadzhov, Y., Klier, A., Kuno, Y., Kurup, A., Kyberd, P., Lagrange, J. -B., Langlands, J., Lau, W., Li, D., Li, Z., Liu, A., Long, K., Lord, T., Macwaters, C., Maletic, D., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Mohayai, T. A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nugent, J. C., Oates, A., Orestano, D., Overton, E., Owens, P., Palladino, V., Palmer, M., Pasternak, J., Pec, V., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ricciardi, S., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Sakamoto, H., Sanders, D. A., Sato, A., Savic, M., Snopok, P., Smith, P. J., Soler, F. J. P., Song, Y., Stanley, T., Stokes, G., Suezaki, V., Summers, D. J., Sung, C. K., Tang, J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tucker, M., Uchida, M. A., Virostek, S., Vankova-Kirilova, G., Warburton, P., Wilbur, S., Wilson, A., Witte, H., White, C., Whyte, C. G., Yang, X., Young, A. R., Zisman, M., Science and Technology Facilities Council (STFC), Imperial College Trust, Council for the Central Laboratory of the Research Councils' (CCLRC), Asfandiyarov, Ruslan, Blondel, Alain, Drielsma, François, and Karadzhov, Yordan Ivanov

Subjects
Accelerator Physics (physics.acc-ph), Physics - Instrumentation and Detectors, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, FOS: Physical sciences, lcsh:Astrophysics, ddc:500.2, Electron, 01 natural sciences, Physics, Particles & Fields, Nuclear physics, Momentum, Pion, DESIGN, 0103 physical sciences, lcsh:QB460-466, Ionization cooling, Thermal emittance, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, High Energy Physics, 010306 general physics, physics.ins-det, 0206 Quantum Physics, Engineering (miscellaneous), QC, physics.acc-ph, Physics, Science & Technology, Muon, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Muon collider, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Experimental High Energy Physics, lcsh:QC770-798, Physics::Accelerator Physics, Physics - Accelerator Physics, Neutrino Factory, High Energy Physics::Experiment
Abstract

The Muon Ionization Cooling Experiment (MICE) collaboration seeks to demonstrate the feasibility of ionization cooling, the technique by which it is proposed to cool the muon beam at a future neutrino factory or muon collider. The emittance is measured from an ensemble of muons assembled from those that pass through the experiment. A pure muon ensemble is selected using a particle identification system that can reject efficiently both pions and electrons. The position and momentum of each muon are measured using a high-precision scintillating-fibre tracker in a 4 T solenoidal magnetic field. This paper presents the techniques used to reconstruct the phase-space distributions in the upstream tracking detector and reports the first particle by-article measurement of the emittance of the MICE Muon Beam as a function of muon-beam momentum. Science and Technology Facilities Council (UK)

Published
2019

5. Effectiveness of Dementia Care Mapping™ to reduce agitation in care home residents with dementia: an open-cohort cluster randomised controlled trial

Author

Surr, CA, Holloway, I, Walwyn, RAE, Griffiths, AW, Meads, D, Martin, A, Farrin, A, Kelley, R, Ballard, C, Fossey, J, Burnley, N, Chenoweth, L, Creese, B, Downs, M, Garrod, L, Graham, EH, Lilley-Kelly, A, McDermid, J, McLellan, V, Millard, H, Perfect, D, Robinson, L, Robinson, O, Shoesmith, E, Siddiqi, N, Stokes, G, Wallace, D, and Farrin, AJ

Abstract

Objectives: Agitation is common and problematic in care home residents with dementia. This study investigated the (cost)effectiveness of Dementia Care Mapping™ (DCM) for reducing agitation in this population. Method: Pragmatic, cluster randomised controlled trial with cost-effectiveness analysis in 50 care homes, follow-up at 6 and 16 months and stratified randomisation to intervention (n = 31) and control (n = 19). Residents with dementia were recruited at baseline (n = 726) and 16 months (n = 261). Clusters were not blinded to allocation. Three DCM cycles were scheduled, delivered by two trained staff per home. Cycle one was supported by an external DCM expert. Agitation (Cohen-Mansfield Agitation Inventory (CMAI)) at 16 months was the primary outcome. Results: DCM was not superior to control on any outcomes (cross-sectional sample n = 675: 287 control, 388 intervention). The adjusted mean CMAI score difference was –2.11 points (95% CI –4.66 to 0.44, p = 0.104, adjusted ICC control = 0, intervention 0.001). Sensitivity analyses supported the primary analysis. Incremental cost per unit improvement in CMAI and QALYs (intervention vs control) on closed-cohort baseline recruited sample (n = 726, 418 intervention, 308 control) was £289 and £60,627 respectively. Loss to follow-up at 16 months in the original cohort was 312/726 (43·0%) mainly (87·2%) due to deaths. Intervention dose was low with only a quarter of homes completing more than one DCM cycle. Conclusion: No benefits of DCM were evidenced. Low intervention dose indicates standard care homes may be insufficiently resourced to implement DCM. Alternative models of implementation, or other approaches to reducing agitation should be considered.

Published
2020

6. Demonstration of cooling by the Muon Ionization Cooling Experiment

Author

Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y. P., Tang, J. Y., Li, Z. H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C. K., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Boyd, S., Greis, J. R., Lord, T., Pidcott, C., Taylor, I., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T. W., Brown, C., Courthold, M., Govans, J., Hills, M., Lagrange, J.-B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J.C., Soler, F. J. P., Chatzitheodoridis, G. T., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Gamet, R., Cooke, P., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P. B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P. J., Wilbur, S., Ellis, M., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., DeMello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Palmer, M., Witte, H., Adey, D., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Coney, L. R., Hanson, G. G., Heidt, C., and collaboration, MICE

Subjects
Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such 'tertiary' beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams1-6. Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness7,8. Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect9-11. The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced footprint6.

Published
2020

9. Lattice design and expected performance of the Muon Ionization Cooling Experiment demonstration of ionization cooling

Author

Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y., Tang, J., Li, Z., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Cecchet, G., Orestano, D., Tortora, L., Kuno, Y., Ishimoto, S., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Hansen, O.M., Ramberger, S., Vretenar, M., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Anderson, R.J., Barclay, P., Bayliss, V., Boehm, J., Bradshaw, T.W., Courthold, M., Francis, V., Fry, L., Hayler, T., Hills, M., Lintern, A., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Wilson, A., Watson, S., Bayes, R., Nugent, J.C., Soler, F.J.P., Gamet, R., Barber, G., Blackmore, V.J., Colling, D., Dobbs, A., Dornan, P., Hunt, C., Kurup, A., Lagrange, J.B., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M.A., Cobb, J.H., Lau, W., Booth, C.N., Hodgson, P., Langlands, J., Overton, E., Robinson, M., Smith, P.J., Wilbur, S., Dick, A.J., Ronald, K., Whyte, C.G., Young, A.R., Boyd, S., Franchini, P., Greis, J.R., Pidcott, C., Taylor, I., Gardener, R.B.S., Kyberd, P., Nebrensky, J.J., Palmer, M., Witte, H., Bross, A.D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Li, D., Prestemon, S., Virostek, S., Freemire, B., Hanlet, P., Kaplan, D.M., Mohayai, T.A., Rajaram, D., Snopok, P., Suezaki, V., Torun, Y., Onel, Y., Cremaldi, L.M., Sanders, D.A., Summers, D.J., Hanson, G.G., Heidt, C., Collaboration, MICE., Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y., Tang, J., Li, Z., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., De Bari, A., Cecchet, G., Orestano, D., Tortora, L., Kuno, Y., Ishimoto, S., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Hansen, O. M., Ramberger, S., Vretenar, M., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Anderson, R. J., Barclay, P., Bayliss, V., Boehm, J., Bradshaw, T. W., Courthold, M., Francis, V., Fry, L., Hayler, T., Hills, M., Lintern, A., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Wilson, A., Watson, S., Bayes, R., Nugent, J. C., Soler, F. J. P., Gamet, R., Barber, G., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Hunt, C., Kurup, A., Lagrange, J. -B., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Lau, W., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Robinson, M., Smith, P. J., Wilbur, S., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Boyd, S., Franchini, P., Greis, J. R., Pidcott, C., Taylor, I., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Palmer, M., Witte, H., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., Demello, A., Gourlay, S., Li, D., Prestemon, S., Virostek, S., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Suezaki, V., Torun, Y., Onel, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Hanson, G. G., and Heidt, C.

Subjects
Nuclear and High Energy Physics, beam dynamics, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, 01 natural sciences, 7. Clean energy, Physics, Particles & Fields, Nuclear physics, secondary beams, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Ionization cooling, Thermal emittance, High Energy Physics, Physics::Atomic Physics, 010306 general physics, QC, physics.acc-ph, Physics, Science & Technology, Muon, 010308 nuclear & particles physics, beam techniques, Surfaces and Interfaces, BEAMS, Accelerators and Storage Rings, Physics, Nuclear, Muon collider, Physical Sciences, Experimental High Energy Physics, lcsh:QC770-798, Physics::Accelerator Physics, High Energy Physics::Experiment, Neutrino Factory, International Muon Ionization Cooling Experiment, Neutrino, beam processes, Beam (structure)
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterized neutrino beams necessary to elucidate the physics of flavor at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using rf cavities. The combined effect of energy loss and reacceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance. Muon beams of low emittance provide the basis for the intense, well-characterised neutrino beams necessary to elucidate the physics of flavour at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using RF cavities. The combined effect of energy loss and re-acceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance.

Published
2017

10. Lattice design and expected performance of the Muon Ionization Cooling Experiment demonstration of ionization cooling

Author

Bogomilov, M, Tsenov, R, Vankova-Kirilova, G, Song, Y, Tang, J, Li, Z, Bertoni, R, Bonesini, M, Chignoli, F, Mazza, R, Palladino, V, De Bari, A, Cecchet, G, Orestano, D, Tortora, L, Kuno, Y, Ishimoto, S, Filthaut, F, Jokovic, D, Maletic, D, Savic, M, Hansen, OM, Ramberger, S, Vretenar, M, Asfandiyarov, R, Blondel, A, Drielsma, F, Karadzhov, Y, Charnley, G, Collomb, N, Dumbell, K, Gallagher, A, Grant, A, Griffiths, S, Hartnett, T, Martlew, B, Moss, A, Muir, A, Mullacrane, I, Oates, A, Owens, P, Stokes, G, Warburton, P, White, C, Adams, D, Anderson, RJ, Barclay, P, Bayliss, V, Boehm, J, Bradshaw, TW, Courthold, M, Francis, V, Fry, L, Hayler, T, Hills, M, Lintern, A, Macwaters, C, Nichols, A, Preece, R, Ricciardi, S, Rogers, C, Stanley, T, Tarrant, J, Tucker, M, Wilson, A, Watson, S, Bayes, R, Nugent, JC, Soler, FJP, Gamet, R, Barber, G, Blackmore, VJ, Colling, D, Dobbs, A, Dornan, P, Hunt, C, Kurup, A, Lagrange, JB, Long, K, Martyniak, J, Middleton, S, Pasternak, J, Uchida, MA, Cobb, JH, Lau, W, Booth, CN, Hodgson, P, Langlands, J, Overton, E, Robinson, M, Smith, PJ, Wilbur, S, Dick, AJ, Ronald, K, Whyte, CG, Young, AR, and Boyd, S

Subjects
Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment, Physics::Atomic Physics
Abstract

© 2017 authors. Published by the American Physical Society. Muon beams of low emittance provide the basis for the intense, well-characterized neutrino beams necessary to elucidate the physics of flavor at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using rf cavities. The combined effect of energy loss and reacceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance.

Published
2017
Full Text
View/download PDF

11. Lattice design and expected performance of the Muon Ionization Cooling Experiment demonstration of ionization cooling

Author

Bogomilov, M, Tsenov, R, Vankova-Kirilova, G, Song, Y, Tang, J, Li, Z, Bertoni, R, Bonesini, M, Chignoli, F, Mazza, R, Palladino, V, de Bari, A, Cecchet, G, Orestano, D, Tortora, L, Kuno, Y, Ishimoto, S, Filthaut, F, Jokovic, D, Maletic, D, Savic, M, Hansen, OM, Ramberger, S, Vretenar, M, Asfandiyarov, R, Blondel, A, Drielsma, F, Karadzhov, Y, Charnley, G, Collomb, N, Dumbell, K, Gallagher, A, Grant, A, Griffiths, S, Hartnett, T, Martlew, B, Moss, A, Muir, A, Mullacrane, I, Oates, A, Owens, P, Stokes, G, Warburton, P, White, C, Adams, D, Anderson, RJ, Barclay, P, Bayliss, V, Boehm, J, Bradshaw, TW, Courthold, M, Francis, V, Fry, L, Hayler, T, Hills, M, Lintern, A, Macwaters, C, Nichols, A, Preece, R, Ricciardi, S, Rogers, C, Stanley, T, Tarrant, J, Tucker, M, Wilson, A, Watson, S, Bayes, R, Nugent, JC, Soler, FJP, Gamet, R, Barber, G, Blackmore, VJ, Colling, D, Dobbs, A, Dornan, P, Hunt, C, Kurup, A, Lagrange, J-B, Long, K, Martyniak, J, Middleton, S, Pasternak, J, Uchida, MA, Cobb, JH, Lau, W, Booth, CN, Hodgson, P, Langlands, J, Overton, E, Robinson, M, Smith, PJ, Wilbur, S, Dick, AJ, Ronald, K, Whyte, CG, Young, AR, Boyd, S, Franchini, P, Greis, JR, and Pidcott, C

Subjects
Physics::Instrumentation and Detectors, Physical Sciences, Physics::Accelerator Physics, High Energy Physics::Experiment, Physics::Atomic Physics, Nuclear & Particles Physics, physics.acc-ph
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterized neutrino beams necessary to elucidate the physics of flavor at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using rf cavities. The combined effect of energy loss and reacceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance.

Published
2017

12. Design and expected performance of the MICE demonstration of ionization cooling

Author

MICE Collaboration, Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y., Tang, J., Li, Z., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Cecchet, G., Orestano, D., Tortora, L., Kuno, Y., Ishimoto, S., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Hansen, O. M., Ramberger, S., Vretenar, M., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Tucker, M., Warburton, P., White, C., Adams, D., Anderson, R. J., Barclay, P., Bayliss, V., Boehm, J., Bradshaw, T. W., Courthold, M., Dumbell, K., Francis, V., Fry, L., Hayler, T., Hills, M., Lintern, A., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Wilson, A., Watson, S., Bayes, R., Nugent, J. C., Soler, F. J. P., Gamet, R., Barber, G., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Hunt, C., Kurup, A., Lagrange, J-B., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Lau, W., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Robinson, M., Smith, P. J., Wilbur, S., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Boyd, S., Franchini, P., Greis, J. R., Pidcott, C., Taylor, I., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Palmer, M., Witte, H., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Li, D., Prestemon, S., Virostek, S., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Suezaki, V., Torun, Y., Onel, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Hanson, G. G., and Heidt, C.

Subjects
Accelerator Physics (physics.acc-ph), Physics::Instrumentation and Detectors, Physics::Accelerator Physics, FOS: Physical sciences, Physics - Accelerator Physics, High Energy Physics::Experiment, Physics::Atomic Physics
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterised neutrino beams necessary to elucidate the physics of flavour at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using RF cavities. The combined effect of energy loss and re-acceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance., Comment: 21 pages, 10 figures

Published
2017
Full Text
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13. Pion contamination in the MICE muon beam

Author

Adams, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Barber, G., Barclay, P., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V.J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C.N., Bowring, D., Boyd, S., Brashaw, T.W., Bravar, U., Bross, A.D., Capponi, M., Carlisle, T., Cecchet, G., Charnley, C., Chignoli, F., Cline, D., Cobb, J.H., Colling, G., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L.M., DeMello, A., Dick, A., Dobbs, A., Dornan, P., Drews, M., Drielsma, F., Filthaut, F., Fitzpatrick, T., Franchini, P., Francis, V., Fry, L., Gallagher, A., Gamet, R., Gardener, R., Gourlay, S., Grant, A., Greis, J.R., Griffiths, S., Hanlet, P., Hansen, O.M., Hanson, G.G., Hart, T.L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Hunt, C., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D.M., Karadzhov, Y., Kim, Y.K., Kuno, Y., Kyberd, P., Lagrange, J-B., Langlands, J., Lau, W., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J.J., Neuffer, D., Nichols, A., Nicholson, R., Nugent, J.C., Oates, A., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M.A., Ricciardi, S., Roberts, T.J., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Rucinski, P., Sakamato, H., Sanders, D.A., Santos, E., Savidge, T., Smith, P.J., Snopok, P., Soler, F.J.P., Speirs, D., Stanley, T., Stokes, G., Summers, D.J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C.D., Uchida, M.A., Vankova-Kirilova, G., Virostek, S., Vretenar, M., Warburton, P., Watson, S., White, C., Whyte, C.G., Wilson, A., Winter, M., Yang, X., Young, A., Zisman, M., Collaboration, MICE, Science and Technology Facilities Council (STFC), Adams, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Barber, G., Barclay, P., De Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V. J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Brashaw, T. W., Bravar, U., Bross, A. D., Capponi, M., Carlisle, T., Cecchet, G., Charnley, C., Chignoli, F., Cline, D., Cobb, J. H., Colling, G., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L. M., Demello, A., Dick, A., Dobbs, A., Dornan, P., Drews, M., Drielsma, F., Filthaut, F., Fitzpatrick, T., Franchini, P., Francis, V., Fry, L., Gallagher, A., Gamet, R., Gardener, R., Gourlay, S., Grant, A., Greis, J. R., Griffiths, S., Hanlet, P., Hansen, O. M., Hanson, G. G., Hart, T. L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Hunt, C., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D. M., Karadzhov, Y., Kim, Y. K., Kuno, Y., Kyberd, P., Lagrange, J. -B., Langlands, J., Lau, W., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nicholson, R., Nugent, J. C., Oates, A., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M. A., Ricciardi, S., Roberts, T. J., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Rucinski, P., Sakamato, H., Sanders, D. A., Santos, E., Savidge, T., Smith, P. J., Snopok, P., Soler, F. J. P., Speirs, D., Stanley, T., Stokes, G., Summers, D. J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C. D., Uchida, M. A., Vankova-Kirilova, G., Virostek, S., Vretenar, M., Warburton, P., Watson, S., White, C., Whyte, C. G., Wilson, A., Winter, M., Yang, X., Young, A., and Zisman, M.

Subjects
Technology, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Beam-line instrumentation (beam position and profile monitors, FOS: Physical sciences, Instrumentation for particle accelerators and storage rings-low energy (linear accelerators, cyclotrons, electrostatic accelerators), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Pion, DESIGN, 0103 physical sciences, Ionization cooling, High Energy Physics, Instrumentation for particle accelerators and storage rings - low energy (linear accelerators,cyclotrons, electrostatic accelerators), Physics::Atomic Physics, Detectors and Experimental Techniques, 010306 general physics, Instruments & Instrumentation, Instrumentation, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), beam-intensity monitor, Mathematical Physics, Physics, Beam-line instrumentation (beam position and profile, monitors, beam-intensity monitors, bunch length monitors), Science & Technology, Muon, CONSTRUCTION, 010308 nuclear & particles physics, Bunch length monitors, Instrumentation and Detectors (physics.ins-det), Contamination, Beam-intensity monitors, Nuclear & Particles Physics, Experimental High Energy Physics, Beam-line instrumentation (beam position and profile monitor, Physics::Accelerator Physics, High Energy Physics::Experiment, Instrumentation for particle accelerators and storage rings - low energy (linear accelerators, cyclotrons, electrostatic accelerators), International Muon Ionization Cooling Experiment, Beam (structure)
Abstract

The international Muon Ionization Cooling Experiment (MICE) will perform a systematic investigation of ionization cooling with muon beams of momentum between 140 and 240\,MeV/c at the Rutherford Appleton Laboratory ISIS facility. The measurement of ionization cooling in MICE relies on the selection of a pure sample of muons that traverse the experiment. To make this selection, the MICE Muon Beam is designed to deliver a beam of muons with less than $\sim$1\% contamination. To make the final muon selection, MICE employs a particle-identification (PID) system upstream and downstream of the cooling cell. The PID system includes time-of-flight hodoscopes, threshold-Cherenkov counters and calorimetry. The upper limit for the pion contamination measured in this paper is $f_��< 1.4\%$ at 90\% C.L., including systematic uncertainties. Therefore, the MICE Muon Beam is able to meet the stringent pion-contamination requirements of the study of ionization cooling., 16 pages, 7 figures

Published
2015

14. A measure of treatment response: patient and physician satisfaction with traditional NSAIDs for osteoarthritis control

Author

Taylor SD, Everett SV, Taylor TN, Watson DJ, and Taylor-Stokes G

Subjects
RC925-935, Diseases of the musculoskeletal system
Abstract

Stephanie D Taylor,1 Sharlette V Everett,1 Thomas N Taylor,2 Douglas J Watson,3 Gavin Taylor-Stokes4 1Global Health Outcomes, Merck Sharp and Dohme Corp, Whitehouse Station, NJ, USA; 2Pharmacy Practice, Wayne State University, Detroit, MI, USA; 3Epidemiology, Merck Sharp and Dohme Corp, Upper Gwynedd, PA, USA; 4Adelphi Real World, Macclesfield, UK Purpose: The clinical response to traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) varies substantially. The objective of this study was to describe physicians’ and patients’ perceptions of response to tNSAIDs as measured by satisfaction with control of patients’ osteoarthritis (OA). Patients and methods: A cross-sectional survey was undertaken in 2009 in Germany, Spain, and the UK. Linked physician and patient questionnaires collected data on OA management, degree of pain and disability, and satisfaction with OA control. Results: The study included 363 treating physicians and 713 patients receiving tNSAIDs. Patient mean (standard deviation) age was 65.5 (11.0) years (range 36–94 years); 60% were women; 86% were white; and one-quarter were obese. Dissatisfaction with control of patients’ OA was expressed by physicians or their patients, or both, for 51% of patients, including 208 patients (31%) with mild OA and 478 patients (60%) with moderate or severe OA. Overall, 37% of patients reported dissatisfaction and 34% had a physician who reported dissatisfaction. Patient and physician assessments were the same in 70% of cases; Cohen’s κ coefficient was 0.34 (95% confidence interval 0.26–0.41), indicating fair agreement. Of those reporting dissatisfaction, most physicians (79%) and patients (64%) believed that the current control was the best that could be achieved. The most common reasons for which physicians reported dissatisfaction were inadequate response (56%), side effects (11.1%), and poor tolerance (7.8%). Conclusion: One-half of patients or their treating physicians were dissatisfied with the control of OA provided by tNSAID therapy; moreover, most believed it was the best control that could be achieved. Keywords: cross-sectional, dissatisfaction, pain, survey

Published
2013

16. Association of patient-rated severity with other outcomes in patients with painful diabetic peripheral neuropathy

Author

Taylor-Stokes G, Pike J, Sadosky A, Chandran A, and Toelle T

Subjects
RC581-951, Specialties of internal medicine, macromolecular substances
Abstract

Gavin Taylor-Stokes1, James Pike1, Alesia Sadosky2, Arthi Chandran2, Thomas Toelle31Adelphi Real World, Adelphi Mill, Bollington, Macclesfield, Cheshire, UK; 2Pfizer Inc, New York, NY, USA; 3Department of Neurology, Technische Universität München, Munich, GermanyObjective: To evaluate the association of patient-reported severity of painful diabetic peripheral neuropathy (pDPN) with other outcomes in a European population of patients using the Adelphi Disease Specific Programme for pDPN (DSP III, 2008).Methods: The severity of patients' pDPN (mild, moderate, or severe) was rated independently by both patients and physicians. Relationships were evaluated between patient-reported pDPN severity and other patient-reported outcomes including pain, sleep, function, and work productivity. Physicians rated the severity of patients’ pDPN (1 = mild, 2 = moderate, 3 = severe) and sleep interference.Results: Patient-reported data were available from 634 individuals (56.2% male, mean age 63 years) from France, Germany, Italy, and the UK, of whom only 22.2% reported that they were currently employed. pDPN severity was rated as mild, moderate, and severe by 22.2%, 60.9%, and 16.9% of the patients, respectively. There was a significant association between patient-rated and physician-rated pDPN severity (P < 0.0001), although there were discrepancies in agreement (kappa = 0.37, 95% confidence interval [CI] 0.31, 0.43; weighted kappa = 0.43, 95% CI 0.37, 0.48) among physician and patient ratings in a substantial proportion of patients across severity categories. Higher pDPN severity was associated with greater interference of daily function including sleep (P < 0.0001 for all pairwise comparisons). Among employed patients, percent of pDPN-related impairment while at work (presenteeism) and overall work impairment increased with greater pDPN severity, resulting in indirect costs that increased significantly with pDPN severity; $8266, $15,449, and $24,300 for mild, moderate, and severe pDPN, respectively (overall P < 0.001).Conclusion: Severity of patient-rated pDPN was significantly associated with outcomes, including function and productivity; poorer function and lower productivity were reported at higher pDPN severity levels. Moreover, physicians rated pDPN severity different from patients in a substantial proportion of patients.Keywords: diabetic neuropathy, pain, outcomes

Published
2011

33. Status of the CLIC-UK R&D programme on design of key systems for the compact linear collider

Author

CLIC, Clarke, J. A., Collomb, N., Steven Jamison, Mcintosh, P. A., Shepherd, B. J. A., Stokes, G., Corsini, R., Grudiev, A., Latina, A., Lefevre, T., Marrelli, C., Modena, M., Schmickler, H., Schulte, D., Skowronski, P., Stapnes, S., Tecker, F., Tomas, R., Wegner, R., Wendt, M., Wuensch, W., Gillespie, W. A., Pan, R., Tyrk, M. A., Walsh, D. A., Bett, D. R., Blaskovic Kraljevic, N., Burrows, P. N., Christian, G. B., Corner, L., Davis, M. R., Gamba, D., Perry, C., Roberts, J., Ainsworth, R., Aumeyr, T., Bobb, L., Boogert, S., Bosco, A., Cullinan, F. J., Karataev, P., Kruchinin, K., Lyapin, A., Graeme Campbell Burt, Amos Dexter, Jenkins, M., Karimian, S., Christopher James Lingwood, Woolley, B., and Jones, R.

35. Status of the CLIC-UK R&D programme on design of key systems for the compact linear collider

Author

Clarke, J. A., Collomb, N., Jamison, S. P., Mcintosh, P. A., Shepherd, B. J. A., Stokes, G., Corsini, R., Grudiev, A., Latina, A., Lefevre, T., Marrelli, C., Modena, M., Schmickler, H., Schulte, D., Skowronski, P., Stapnes, S., Tecker, F., Tomas, R., Wegner, R., Wendt, M., Wuensch, W., Gillespie, W. A., Pan, R., Tyrk, M. A., Walsh, D. A., Bett, D. R., Blaskovic Kraljevic, N., Burrows, P. N., Christian, G. B., Corner, L., Davis, M. R., Gamba, D., Perry, C., Roberts, J., Ainsworth, R., Aumeyr, T., Bobb, L., Boogert, S., Bosco, A., Cullinan, F. J., Karataev, P., Kruchinin, K., Lyapin, A., Nevay, L. J., Snuverink, J., Towler, J. R., Burt, G., Dexter, A., Jenkins, M., Karimian, S., Lingwood, C., Woolley, B., Roger Jones, and Praveen Kumar, A. V.

41. Electron-muon ranger: performance in the MICE muon beam

Author

D. Adams, A. Alekou, M. Apollonio, R. Asfandiyarov, G. Barber, P. Barclay, A. de Bari, R. Bayes, V. Bayliss, P. Bene, R. Bertoni, V.J. Blackmore, A. Blondel, S. Blot, M. Bogomilov, M. Bonesini, C.N. Booth, D. Bowring, S. Boyd, T.W. Bradshaw, U. Bravar, A.D. Bross, F. Cadoux, M. Capponi, T. Carlisle, G. Cecchet, C. Charnley, F. Chignoli, D. Cline, J.H. Cobb, G. Colling, N. Collomb, L. Coney, P. Cooke, M. Courthold, L.M. Cremaldi, S. Debieux, A. DeMello, A. Dick, A. Dobbs, P. Dornan, F. Drielsma, F. Filthaut, T. Fitzpatrick, P. Franchini, V. Francis, L. Fry, A. Gallagher, R. Gamet, R. Gardener, S. Gourlay, A. Grant, J.S. Graulich, J. Greis, S. Griffiths, P. Hanlet, O.M. Hansen, G.G. Hanson, T.L. Hart, T. Hartnett, T. Hayler, C. Heidt, M. Hills, P. Hodgson, C. Hunt, C. Husi, A. Iaciofano, S. Ishimoto, G. Kafka, D.M. Kaplan, Y. Karadzhov, Y.K. Kim, Y. Kuno, P. Kyberd, J.-B. Lagrange, J. Langlands, W. Lau, M. Leonova, D. Li, A. Lintern, M. Littlefield, K. Long, T. Luo, C. Macwaters, B. Martlew, J. Martyniak, F. Masciocchi, R. Mazza, S. Middleton, A. Moretti, A. Moss, A. Muir, I. Mullacrane, J.J. Nebrensky, D. Neuffer, A. Nichols, R. Nicholson, L. Nicola, E. Noah Messomo, J.C. Nugent, A. Oates, Y. Onel, D. Orestano, E. Overton, P. Owens, V. Palladino, J. Pasternak, F. Pastore, C. Pidcott, M. Popovic, R. Preece, S. Prestemon, D. Rajaram, S. Ramberger, M.A. Rayner, S. Ricciardi, T.J. Roberts, M. Robinson, C. Rogers, K. Ronald, K. Rothenfusser, P. Rubinov, P. Rucinski, H. Sakamato, D.A. Sanders, R. Sandström, E. Santos, T. Savidge, P.J. Smith, P. Snopok, F.J.P. Soler, D. Speirs, T. Stanley, G. Stokes, D.J. Summers, J. Tarrant, I. Taylor, L. Tortora, Y. Torun, R. Tsenov, C.D. Tunnell, M.A. Uchida, G. Vankova-Kirilova, S. Virostek, M. Vretenar, P. Warburton, S. Watson, C. White, C.G. Whyte, A. Wilson, H. Wisting, X. Yang, A. Young, M. Zisman, Science and Technology Facilities Council (STFC), Adams, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Barber, G., Barclay, P., De Bari, A., Bayes, R., Bayliss, V., Bene, P., Bertoni, R., Blackmore, V. J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bravar, U., Bross, A. D., Cadoux, F., Capponi, M., Carlisle, T., Cecchet, G., Charnley, C., Chignoli, F., Cline, D., Cobb, J. H., Colling, G., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L. M., Debieux, S., Demello, A., Dick, A., Dobbs, A., Dornan, P., Drielsma, F., Filthaut, F., Fitzpatrick, T., Franchini, P., Francis, V., Fry, L., Gallagher, A., Gamet, R., Gardener, R., Gourlay, S., Grant, A., Graulich, J. S., Greis, J., Griffiths, S., Hanlet, P., Hansen, O. M., Hanson, G. G., Hart, T. L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Hunt, C., Husi, C., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D. M., Karadzhov, Y., Kim, Y. K., Kuno, Y., Kyberd, P., Lagrange, J. -B., Langlands, J., Lau, W., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Masciocchi, F., Mazza, R., Middleton, S., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nicholson, R., Nicola, L., Messomo, E. N., Nugent, J. C., Oates, A., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M. A., Ricciardi, S., Roberts, T. J., Robinson, M., Rogers, C., Ronald, K., Rothenfusser, K., Rubinov, P., Rucinski, P., Sakamato, H., Sanders, D. A., Sandstrom, R., Santos, E., Savidge, T., Smith, P. J., Snopok, P., Soler, F. J. P., Speirs, D., Stanley, T., Stokes, G., Summers, D. J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C. D., Uchida, M. A., Vankova-Kirilova, G., Virostek, S., Vretenar, M., Warburton, P., Watson, S., White, C., Whyte, C. G., Wilson, A., Wisting, H., Yang, X., Young, A., Zisman, M., and Palladino, Vittorio

Subjects
Technology, Physics - Instrumentation and Detectors, Traverse, Physics::Instrumentation and Detectors, FOS: Physical sciences, Electron, Cooling channel, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Particle identification method, Particle identification methods, Calorimeters, DESIGN, Particle tracking detectors, 0103 physical sciences, Ionization cooling, Detectors and Experimental Techniques, Nuclear Experiment, 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Instrumentation, Instruments & Instrumentation, QC, Mathematical Physics, Physics, Calorimeter, Range (particle radiation), Muon, Science & Technology, 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Particle tracking detector, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Performance of High Energy Physics Detectors, Beam (structure)
Abstract

The Muon Ionization Cooling Experiment (MICE) will perform a detailed study of ionization cooling to evaluate the feasibility of the technique. To carry out this program, MICE requires an efficient particle-identification (PID) system to identify muons. The Electron-Muon Ranger (EMR) is a fully-active tracking-calorimeter that forms part of the PID system and tags muons that traverse the cooling channel without decaying. The detector is capable of identifying electrons with an efficiency of 98.6%, providing a purity for the MICE beam that exceeds 99.8%. The EMR also proved to be a powerful tool for the reconstruction of muon momenta in the range 100-280 MeV/$c$., 22 pages, 19 figures

Published
2015

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