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Idiopathic as well as nonspecific low back pain is relevant in health care systems as well asinleisure and high-performance sports. Neuromuscular and/or structural deficits, mostly accompanied by biopsychological factors,are known risk factors for both the onset and chronification of symptoms. Meta-analytic evidence describes positive effects of physical activity. However, type, dose-response relation, minimum of training required and setting-specific implementation has not been fullyclarified. Since 2011, the national research network Medicine in Spine Exercise [MiSpEx] has beenfollowing a project layout called Ran Rcken focussing on the development and validation of intervention programs including neuromuscular and pain adaptation moderated by individual training status, pain behaviour, allostatic load and social settings. Overall about 8000 patients and athletes have been and are being followed experimentally and clinically in 34 studies. It could be shownthat a training program focussing on compensation of external loads elicited by perturbations is effective in prevention and rehabilitation in both athletes and general population. Besides validation of further consecutively developed programs emphasis is put on the evaluation of transfer strategies to medical systems, sports as well as general population. Finally, the evaluation of an efficient dose-response relation is addressed.KEY WORDS: Low Back Pain, MiSpEx, Sports, Perturbations, Therapy, Prevention, Training

In the MiSpEx project, the statistical analysis of main research questions accompanied by the aggregation of diverse data obtained in the individual studies represents a particular challenge. Research goals relating to the effectiveness and efficiency of training interventions in order to reduce the risk and degree of back pain may be addressed by meta-analyticalapproaches. This requires a sufficient similarity of the underlying studies and, in case of applying a meta-analysis of individual data,uniformly structured data sets. Approaches of supervised statistical learning should be applied to research goals concerning the diagnosis of back pain, and the prognosis either of further course of symptoms and of the reaction to preventive and curative interventions. The various underlying data sets should enable a step-by-step approach with several development and validation steps, likewise provided that sufficient comparability exists. The assessment of moderating effects of the influencing factors pain experience, training status, psychophysical distress, and level of care on treatment success is of high importance.KEY WORDS: Aggregation, Analysis Strategy, Prevention, Back Pain

Fragestellung: Die Messung des Frontalebenen-Projektionswinkels (FPPA) mittels Huddle-Technique-App ist ein neues video-assoziiertes Instrument, um Kniegelenkinstabilitäten von Leistungssportlern zu ermitteln. Ein Vergleich wird zu etabliert angewandten Winkelmessungen, KT 1000 und KLT Storz sowie[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Based on the results of a pilot study in 2007, which found high mixing ratios of molecular iodine (I2) above the intertidal macroalgae (seaweed) beds at Mweenish Bay (Ireland), we extended the study to nine different locations in the vicinity of Mace Head Atmospheric Research Station on the west coast of Ireland during a field campaign in 2009. The mean values of I2 mixing ratio found above the macroalgae beds at nine different locations ranged from 104 to 393 ppt, implying a high source strength of I2. Such mixing ratios are sufficient to result in photochemically driven coastal new-particle formation events. Mixing ratios above the Ascophyllum nodosum and Fucus vesiculosus beds increased with exposure time: after 6 h exposure to ambient air the mixing ratios were one order of magnitude higher than those initially present. This contrasts with the emission characteristics of Laminaria digitata, where most I2 was emitted within the first half hour of exposure. Discrete in situ measurements (offline) of I2 emission from ambient air-exposed chamber experiments of L. digitata, A. nodosum and F. vesiculosus substantially supported the field observations. Further online and time-resolved measurements of the I2 emission from O3-exposed macroalgal experiments in a chamber confirmed the distinct I2 emission characteristics of A. nodosum and F. vesiculosus compared to those of L. digitata. The emission rates of A. nodosum and F. vesiculosus were comparable to or even higher than L. digitata after the initial exposure period of ~20–30 min. We suggest that A. nodosum and F. vesiculosus may provide an important source of photolabile iodine in the coastal boundary layer and that their impact on photochemistry and coastal new-particle formation should be reevaluated in light of their longer exposure at low tide and their widespread distribution., Atmospheric Chemistry and Physics, 13 (10), ISSN:1680-7375, ISSN:1680-7367

AIM Because of the low prevalence, there is poor evidence on the effective management of bone and joint infections of the carpus and metacarpus. We therefore studied the outcomes of patients undergoing surgical treatment at our department. METHOD We conducted a retrospective study on all patients operated on because of osteomyelitis of the carpus and metacarpus between January 1998 and June 2004. Main study endpoint were the infection control rate at end of treatment and at time of follow-up. RESULTS Of eleven subjects (nine men, two women) with a median age of 43 years (range, 19 to 79 years) serial debridement with temporary wound closure and surgical fixation proved successful in ten cases. We identified causative pathogens in ten cases (S. aureus: n = 3, P. aeruginosa: n = 3, mixed: n = 4) by intraoperative biopsy. Eight subjects received local or free tissue flaps. A 73 year old man died in hospital. Follow-up information was available for eight patients after a median of 19.5 months (range: 3 to 61 months). Seven of them did not show signs of recurrent infection. CONCLUSION Adhering to accepted standards of treating osteomyelitis, satisfactory control rates in carpal and metacarpal infection can be achieved while salvaging the hand.

Objective: The Dutch hydrocephalus study in the 1990s proved the superiority of LPVs in the therapy of the idiopathic normal pressure hydrocephalus and simultaneously uncovered the enormous risk of overdrainage complications for the use of low pressure valves without a gravitational compensation. The[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: Among the dementia diseases, the idiopathic normal pressure hydrocephalus is the only entity treatable by neurosurgical therapy. Although the effectiveness of shunt surgery is unquestioned, the risk of overdrainage complications had a major influence on the indication for surgery in the past.[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: The supremacy of low-pressure valves (LPV) in the therapy of patients with idiopathic normal pressure hydrocephalus (iNPH) has been proven by Dutch NPH study. The downside of LPV is the high rate of over drainage complications. The goal of this prospective randomized controlled multicenter[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Fragestellung: Durch die Definition des komplexen Beckentraumas hat sich eine sofortige Notfallbehandlung etabliert. Im Fokus der vorliegenden Untersuchung lag das Vorliegen einer komplexen Beckenverletzung bei Pat. über 60 Jahre. Durch Auswertung der multizentrischen Beckenstudie der AG Becken[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Die Therapie der Kniegelenksluxation wird nach wie vor kontrovers diskutiert, die derzeit vorhandenen Daten basieren auf Studien mit meist niedriger Evidenz. Nach wie vor nicht geklärt ist die Frage der primären Naht versus primärer Rekonstruktion von VKB und HKB. Ziel[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Beckenringverletzungen stellen immer noch eine Herausforderung in der Primärversorgung von Schwerverletzten dar und repräsentieren eine Untergruppe von Patienten die eine hohe Mortalität aufweisen, vielfach nur mit Behinderungen ausheilen und hohe Behandlungskosten generieren.[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Kann die Durchführung einer Ganzkörper-CT-Untersuchnug in der Initialphase nach Aufnahme eines polytraumatisierten Patienten mit einem ISS ≥16 die Überlebenswahrscheinlichkeit verbessern? Methodik: In den letzten Jahren wird zunehmend die Forderung nach der[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Die Abschätzung des äußeren Blutverlustes nach Trauma am Unfallort ist wichtig. Stichhaltige Untersuchungen bezüglich der Genauigkeit dieser Einschätzung fehlen allerdings. Ziel der vorliegenden Untersuchung war es, die Schätzgenauigkeit durch Notärzte[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Bei der Versorgung von geschlossenen und I° offenen Tibiaschaftfrakturen ist die Marknagelosteosynthese ein etabliertes Standardverfahren. Trotz standartisierter Operationsverfahren und kontinuierlich weiter entwickelter Implantate sind Komplikationen (verzögerte Knochenbruchheilung,[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Atherosclerosis Supplements

Human plasma PAF-AH (platelet-activating factor-acetylhydrolase) is a Ca2+-independent phospholipase A(2) of hematopoietic origin associated with LDL and HDL; it degrades PAF and oxidizes phospholipids. We show that human macrophages synthesize PAF-AH as a premedial Golgi precursor containing high mannose N-linked glycans. Secreted PAF-AH possesses a molecular mass of similar to 55 kDa and contains mature N-linked glycans. Secreted PAF-AH activity (90 +/- 4% of the total) bound to a wheat germ lectin column and could be eluted with N-acetylglucosamine, whereas digestion with N-acetylneuraminidase II completely abolished enzyme absorption. Tunicamycin significantly reduced cell-associated PAN-AH activity and inhibited enzyme secretion; but it did not alter the ratio of secreted to cell-associated enzyme (1.8 at 6 h and 3.1 at 24 h), suggesting that glycosylation is not essential for PAF-AH secretion. Digestion of cell-associated PAF-AH or secreted PAF-AH with peptide N-glycosidase F affected neither catalytic activity nor its resistance to proteolysis with trypsin or proteinase K, in addition, it did not affect PAF-AH association with LDL, but significantly increased its association with HDL. jlr We suggest that macrophage-derived PAF-AH contains heterogeneous asparagine-conjugated sugar chain(s) involving sialic acid, which hinders its association with HDL but does not influence the secretion, catalytic activity, or resistance of PAF-AH to proteases. Journal of Lipid Research