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Far-ultraviolet (FUV; ∼1200-2000 Å) spectra are fundamental to our understanding of star-forming galaxies, providing a unique window on massive stellar populations, chemical evolution, feedback processes, and reionization. The launch of the James Webb Space Telescope will soon usher in a new era, pushing the UV spectroscopic frontier to higher redshifts than ever before; however, its success hinges on a comprehensive understanding of the massive star populations and gas conditions that power the observed UV spectral features. This requires a level of detail that is only possible with a combination of ample wavelength coverage, signal-to-noise, spectral-resolution, and sample diversity that has not yet been achieved by any FUV spectral database. We present the Cosmic Origins Spectrograph Legacy Spectroscopic Survey (CLASSY) treasury and its first high-level science product, the CLASSY atlas. CLASSY builds on the Hubble Space Telescope (HST) archive to construct the first high-quality (S/N1500 Å ≳ 5/resel), high-resolution (R ∼ 15,000) FUV spectral database of 45 nearby (0.002 < z < 0.182) star-forming galaxies. The CLASSY atlas, available to the public via the CLASSY website, is the result of optimally extracting and coadding 170 archival+new spectra from 312 orbits of HST observations. The CLASSY sample covers a broad range of properties including stellar mass (6.2 < log M ⋆(M ⊙) < 10.1), star formation rate (−2.0 < log SFR (M ⊙ yr−1) < +1.6), direct gas-phase metallicity (7.0 < 12+log(O/H) < 8.8), ionization (0.5 < O32 < 38.0), reddening (0.02 < E(B − V) < 0.67), and nebular density (10 < n e (cm−3) < 1120). CLASSY is biased to UV-bright star-forming galaxies, resulting in a sample that is consistent with the z ∼ 0 mass-metallicity relationship, but is offset to higher star formation rates by roughly 2 dex, similar to z ≳ 2 galaxies. This unique set of properties makes the CLASSY atlas the benchmark training set for star-forming galaxies across cosmic time.

The COS Legacy Archive Spectroscopic SurveY (CLASSY) is designed to provide the community with a spectral atlas of 45 nearby star-forming galaxies which were chosen to cover similar properties as those seen at high-z (z>6). The prime high level science product of CLASSY is accurately coadded UV spectra, ranging from ~1000-2000A, derived from a combination of archival and new data obtained with HST's Cosmic Origins Spectrograph (COS). This paper details the multi-stage technical processes of creating this prime data product, and the methodologies involved in extracting, reducing, aligning, and coadding far-ultraviolet (FUV) and near-ultraviolet (NUV) spectra. We provide guidelines on how to successfully utilize COS observations of extended sources, despite COS being optimized for point sources, and best-practice recommendations for the coaddition of UV spectra in general. Moreover, we discuss the effects of our reduction and coaddition techniques in the scientific application of the CLASSY data. In particular, we find that accurately accounting for flux calibration offsets can affect the derived properties of the stellar populations, while customized extractions of NUV spectra for extended sources are essential for correctly diagnosing the metallicity of galaxies via CIII] nebular emission. Despite changes in spectral resolution of up to ~25% between individual datasets (due to changes in the COS line spread function), no adverse affects were observed on the difference in velocity width and outflow velocities of isolated absorption lines when measured in the final combined data products, owing in-part to our signal-to-noise regime of S/N, 31 pages, 17 figures, accepted for publication in ApJS

A discussion of science cases in extragalactic astrophysics and galaxy formation that wide-area space-based infrared surveys will address in the 2020s.

The rest-frame UV emission from massive stars contains a wealth of information about the physical nature and conditions of star formation in galaxies. Using studies of the rest-frame UV, the past decade has witnessed the beginning of knowledge about the existence and properties of galaxies during the first few billion years after the Big Bang. This period of history corresponds to the formation of the first stars, the rapid formation of galaxy stellar populations, the reionization of the IGM, the production and dissemination of heavy elements, and the formation of the first black holes. Massive stars in these galaxies drive all of these events, and their light dominates the spectral energy distributions of galaxies. As we look to the 2020s, fundamental questions remain about the nature of these stellar populations and their evolution, from just before the peak of the cosmic star formation density (z~3), up to the epoch of reionization (z > 6). This next decade will provide transformative gains both in our ability to identify star-forming galaxies and accreting supermassive black holes at these early epochs with imaging surveys in the rest-frame UV (e.g., LSST, WFIRST). Ground-based, rest-frame UV spectroscopy on >20 m-class telescopes (e.g., GMT/TMT) offers the ability to investigate the astrophysical conditions in galaxies at the earliest cosmic times. This includes studies of the evolution in galaxy stellar populations, gas ionization (temperature, pressure), metallicity, and interstellar (and circumgalactic) gas kinematics and covering fractions. In this white paper, we describe the scientific prospects and the requirements for research in this area., White paper submitted to the Astro2020 Decadal Survey (8 papers, 4 figures)

The epoch of reionization (6 < z < 10) marks the period in our universe when the first large galaxies grew to fruition, and began to affect the universe around them. Massive stars, and potentially accreting supermassive black holes, filled the universe with ionizing radiation, burning off the haze of neutral gas that had filled the intergalactic medium (IGM) since recombination (z~1000). The evolution of this process constrains key properties of these earliest luminous sources, thus observationally constraining reionization is a key science goal for the next decade. The measurement of Lyman-alpha emission from photometrically-identified galaxies is a highly constraining probe of reionization, as a neutral IGM will resonantly scatter these photons, reducing detectability. While significant work has been done with 8-10m telescopes, these observations require extremely large telescopes (ELTs); the flux limits available from today's 10m class telescopes are sufficient for only the brightest known galaxies (m < 26). Ultra-deep surveys with the Giant Magellan Telescope (GMT) and Thirty Meter Telescope (TMT) will be capable of detecting Lyman-alpha emission from galaxies 2-3 magnitudes fainter than today's deepest surveys. Wide-field fiber spectroscopy on the GMT combined with narrow-field AO-assisted slit spectroscopy on the TMT will be able to probe the expected size of ionized bubbles throughout the epoch of reionization, following up degree scale deep imaging surveys with the Wide Field Infrared Space Telescope. These data will provide the first resolved Lyman-alpha-based maps of the ionized intergalactic medium throughout the epoch of reionization, constraining models of both the temporal and spatial evolution of this phase change., White paper submitted to the Astro2020 Decadal Review of the National Academy of Sciences

Objective: International recognition of the unique needs of young people with cancer is growing. Many countries have developed specialist age-appropriate cancer services believing them to be of value. In England, 13 specialist Principal Treatment Centres (PTC) deliver cancer care to young people. Despite this expansion of specialist care, systematic investigation of associated outcomes and costs has to date, been lacking. The aim of this paper is to describe recruitment and baseline characteristics of the BRIGHTLIGHT cohort, and the development of the bespoke measures of levels of care and disease severity, which will inform the evaluation of cancer services in England. Design: Prospective, longitudinal, observational study. Setting: Ninety-seven NHS hospitals in England. Participants: A total of 1,114 participants were recruited diagnosed between July 2012 and December 2014: 55% (n=618) male, mean age was 20.1 years (SD=3.3), most (86%) were white and most common diagnoses were lymphoma (31%), germ cell tumour (19%) and leukaemia (13%). Results: At diagnosis, median quality of life score was significantly lower than a published control threshold (69.7 points); 40% had borderline-severe anxiety, and 21% had borderlinesevere depression. There was minimal variation in other patient-reported outcomes according to age, diagnosis or severity of illness. Survival was significantly worse in the Cohort than for young people diagnosed during the same period who were not recruited (cumulative survival probability 4 years after diagnosis: 88% vs. 92%). Conclusions: Data collection was completed in March 2018. Longitudinal comparisons will determine outcomes and costs associated with access/exposure to PTCs. Findings will inform international intervention and policy initiatives to improve outcomes for young people with cancer.

International audience; CETUS is a 1.5-m, wide-field UV observatory that will be a worthy successor to Hubble. Its distinguishing characteristics include multi-object slit spectroscopy, long-slit spectroscopy, spectroscopy in the Lyman-UV, prompt-response observations, and detection of low-surface brightness objects. These new capabilities ensure future discoveries.

This talk focuses on evolution of galaxies similar to the Milky Way. Magnification from gravitational lensing offers a promising way to study these galaxies at intermediate redshifts, which are otherwise poorly resolved in current surveys. I discuss measurements of gas kinematics and chemical abundances, which reveal in situ formation of thick disks in Milky Way-like galaxies at z~2.

Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.