16 results on '"Spiteri G."'
Search Results
2. Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021
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Funk T., Pharris A., Spiteri G., Bundle N., Melidou A., Carr M., Gonzalez G., Garcia-Leon A., Crispie F., O'Connor L., Murphy N., Mossong J., Vergison A., Wienecke-Baldacchino A. K., Abdelrahman T., Riccardo F., Stefanelli P., Di Martino A., Bella A., Lo Presti A., Casaca P., Moreno J., Borges V., Isidro J., Ferreira R., Gomes J. P., Dotsenko L., Suija H., Epstein J., Sadikova O., Sepp H., Ikonen N., Savolainen-Kopra C., Blomqvist S., Mottonen T., Helve O., Gomes-Dias J., Adlhoch C., Macori G., Russell L., Yandle Z., Bennett C., O'Byrne E., Murphy A., Tuite G., Conroy A., Duffy M., Morley U., Keoghan B., Ford I., Kennedy M., McDonnell S., Flynn A., Clarke A., Crowley A., Martin C., Kelly E., Foxton J., Hare D., Dunford L., Connell J., Moran J., Dean J., Fanning S., Rajan L., De Gascun C., Kenny J., Cotter P., Walsh C., Lawton E., Fitzpatrick A., Mullins E., Della Bartola M., McCabe M., Stapleton P., Meaney C., Fanning L., Prentice M., MacSharry J., Dempsey C., Mallon P., Leon A., Chaturvedi A., Coughlan S., McAndrew G., Reddington K., Walsh F., Fitzpatrick D., Smyth C., O'Dwyer T., Chambers T., Clarke L., Jebb D., Klopp J., Kavanagh D., Haslam K., Buckley P., Lemass K., Fitzpatrick F., Burns K., Cafferkey J., Richmond A., Foley M., Sanchez-Morgado J., Chalapati S., Pinnamaneni N., Crosbie C., Limbachiya D., Tinago W., Garcia Leon A. A., Miles S., Alalwan D., Negi R., Macken A., Feeney E., Kenny G., McCann K., Kelly N., Blair M., McCann R., Kenny C., O'Brion C., Waqas S., Savinelli S., Doran P., Bracken T., Varghese P., Lambert J. S., Cotter A., Muldoon E., Sheehan G., McGinty T., Lambert J., Green S., Leamy K., de Barra E., McConkey S., Kelly C., Horgan M., Sadlier C., Yousif O., O'Donnell J., Fitzgerald M., Petty-Saphon N., Cuddihy J., Fiore S., Fabiani C., Benedetti E., Di Mario G., Facchini M., Puzelli S., Calzoletti L., Fontana S., Venturi G., Fortuna C., Marsili G., Amendola A., Stuppia L., Savini G., Picerno A., Lopizzo T., Dell'Edera D., Minchella P., Greco F., Mauro M. V., Viglietto G., Atripaldi L., Limone A., D'Agaro P., Licastro D., Marcello A., Capobianchi M. R., Icardi G., Bruzzone B., Lillo F., Orsi A., Pariani E., Baldanti F., Gismondo M. R., Maggi F., Caruso A., Ceriotti F., Boniotti B., Bagnarelli P., Garofalo S., Scutella M., Pagani E., Collini L., Ghisetti V., Ru G., Chironna M., Parisi A., Rubino S., Serra C., Piras G., Coghe F., Vitale F., Tramuto F., Scalia G., Palermo C. I., Mancuso G., Di Gaudio F., Vullo S., Reale S., Cusi M. G., Rossolini G. M., Pistello M., Mencacci A., Camilloni B., Severini S., Di Benedetto M., Calogero T., Monne I., Biscaro V., COVID Study Groups, Funk T., Pharris A., Spiteri G., Bundle N., Melidou A., Carr M., Gonzalez G., Garcia-Leon A., Crispie F., O'Connor L., Murphy N., Mossong J., Vergison A., Wienecke-Baldacchino A.K., Abdelrahman T., Riccardo F., Stefanelli P., Di Martino A., Bella A., Lo Presti A., Casaca P., Moreno J., Borges V., Isidro J., Ferreira R., Gomes J.P., Dotsenko L., Suija H., Epstein J., Sadikova O., Sepp H., Ikonen N., Savolainen-Kopra C., Blomqvist S., Mottonen T., Helve O., Gomes-Dias J., Adlhoch C., Macori G., Russell L., Yandle Z., Bennett C., O'Byrne E., Murphy A., Tuite G., Conroy A., Duffy M., Morley U., Keoghan B., Ford I., Kennedy M., McDonnell S., Flynn A., Clarke A., Crowley A., Martin C., Kelly E., Foxton J., Hare D., Dunford L., Connell J., Moran J., Dean J., Fanning S., Rajan L., De Gascun C., Kenny J., Cotter P., Walsh C., Lawton E., Fitzpatrick A., Mullins E., Della Bartola M., McCabe M., Stapleton P., Meaney C., Fanning L., Prentice M., MacSharry J., Dempsey C., Mallon P., Leon A., Chaturvedi A., Coughlan S., McAndrew G., Reddington K., Walsh F., Fitzpatrick D., Smyth C., O'Dwyer T., Chambers T., Clarke L., Jebb D., Klopp J., Kavanagh D., Haslam K., Buckley P., Lemass K., Fitzpatrick F., Burns K., Cafferkey J., Richmond A., Foley M., Sanchez-Morgado J., Chalapati S., Pinnamaneni N., Crosbie C., Limbachiya D., Tinago W., Garcia Leon A.A., Miles S., Alalwan D., Negi R., Macken A., Feeney E., Kenny G., McCann K., Kelly N., Blair M., McCann R., Kenny C., O'Brion C., Waqas S., Savinelli S., Doran P., Bracken T., Varghese P., Lambert J.S., Cotter A., Muldoon E., Sheehan G., McGinty T., Lambert J., Green S., Leamy K., de Barra E., McConkey S., Kelly C., Horgan M., Sadlier C., Yousif O., O'Donnell J., Fitzgerald M., Petty-Saphon N., Cuddihy J., Fiore S., Fabiani C., Benedetti E., Di Mario G., Facchini M., Puzelli S., Calzoletti L., Fontana S., Venturi G., Fortuna C., Marsili G., Amendola A., Stuppia L., Savini G., Picerno A., Lopizzo T., Dell'Edera D., Minchella P., Greco F., Mauro M.V., Viglietto G., Atripaldi L., Limone A., D'Agaro P., Licastro D., Marcello A., Capobianchi M.R., Icardi G., Bruzzone B., Lillo F., Orsi A., Pariani E., Baldanti F., Gismondo M.R., Maggi F., Caruso A., Ceriotti F., Boniotti B., Bagnarelli P., Garofalo S., Scutella M., Pagani E., Collini L., Ghisetti V., Ru G., Chironna M., Parisi A., Rubino S., Serra C., Piras G., Coghe F., Vitale F., Tramuto F., Scalia G., Palermo C.I., Mancuso G., Di Gaudio F., Vullo S., Reale S., Cusi M.G., Rossolini G.M., Pistello M., Mencacci A., Camilloni B., Severini S., Di Benedetto M., Calogero T., Monne I., Biscaro V., and COVID Study Groups
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Infecções Respiratórias ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Critical Care ,Epidemiology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,variants of concern ,Settore MED/42 - Igiene Generale E Applicata ,03 medical and health sciences ,0302 clinical medicine ,Virology ,Internal medicine ,Medicine ,Humans ,Intensive care admission ,030212 general & internal medicine ,COVID-19 ,Europe ,SARS-CoV-2 ,surveillance ,Surveillance ,business.industry ,030503 health policy & services ,Public Health, Environmental and Occupational Health ,Odds ratio ,Confidence interval ,Variants of Concern ,COVID-19, Europe, SARS-CoV-2, surveillance, variants of concern ,0305 other medical science ,business ,Rapid Communication ,Human - Abstract
COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8). ECDC internal funds. The ICSC and the AIID Cohort are supported by Science Foundation Ireland under the Science Foundation Ireland, Enterprise Ireland, IDA Ireland COVID-19 Rapid Response Funding Call (Grant number: COVID-RRC 20/COV/0103 and COVID-RRC 20/COV/0305). info:eu-repo/semantics/publishedVersion
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- 2021
3. Salute e sicurezza sul lavoro nelle sale operatorie ibride: un’analisi ergonomica
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Monaco, M. G. L., Carta, A., Spiteri, G., Barooty, A., Conforti, R., Maran, F., Rostello, M., Tamhid, T., Visentin, M., and Porru, S.
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sale operatorie ,ibride ,salute e sicurezza - Published
- 2022
4. Riduzione del consumo di sale tra i lavoratori della sanità: efficacia di un intervento di promozione della salute
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Spiteri, G., Monaco, M. G. L., Tamhid, T., Taus, F., Torroni, L., Verlato, G., Carta, A., and Porru, S.
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sanitari ,promozione salute ,sale - Published
- 2022
5. Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study
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Visci G, Zunarelli C, Mansour I, Porru S, De Palma G, Duval X, Monaco MGL, Spiteri G, Carta A, Lippi G, Verlato G, Sansone E, Sala E, Lombardo M, Abedini M, Violante F, Boffetta P.
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- 2022
- Full Text
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6. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018
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Merdrignac L, Aït El Belghiti F, Pandolfi E, Jané M, Murphy J, Fabiánová K, García Cenoz M, Flem E, Guillot S, Tozzi AE, Carmona G, Habington A, Zavadilová J, Navasués A, Bøås H, Lévy-Brühl D, Ferretti B, Miguel Lanaspa Pérez, O'Sullivan N, Krížová P, Fernandino L, Bekkevold T, Hanslik T, Munoz-Almagro C, Bacci S, Spiteri G, Valenciano M, Moren A, PERTINENT Group, and PERTINENT group
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pertussis ,active surveillance ,hospital surveillance ,pertussis incidence - Abstract
IntroductionPERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites).AimThis observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity.MethodsWe developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites' annual incidences by dividing case numbers by the catchment populations.ResultsFrom December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0-11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700-4,925; IQR: 720) and 39 weeks (range: 25-42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway.ConclusionsIncidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.
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- 2021
7. Patologie non neoplastiche da esposizione lavorativa ad amianto
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Porru, S, Feroldi, E, and Spiteri, G
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benign pleural abnormalities - occupational exposures - ex exposed ,pleuropatie benigne ,ex esposti ,asbestosi ,asbestosi, pleuropatie benigne, esposizione occupazionale, ex esposti ,esposizione occupazionale - Published
- 2018
8. Travel-associated gonorrhoea in four Nordic countries, 2008 to 2013
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Beauté, J, Cowan, S, Hiltunen-Back, E, Kløvstad, Hilde, Velicko, I, and Spiteri, G
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- 2017
9. Trends in HIV surveillance data in the EU/EEA, 2005 to 2014: New HIV diagnoses still increasing in men who have sex with men
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Pharris, Anastasia, Quinten, C., Tavoschi, L., Spiteri, G., Amato-Gauci, A. J., Schmid, D., Sasse, A., Beckhoven, D. Van, Varleva, T., Blazic, Tatjana Nemeth, Koliou, M., Hadjihannas, L., Maly, M., Cowan, Susan, Rüütel, K., Liitsola, K., Salminen, M., Cazein, F., Pillonel, J., Lot, F., Gunsenheimer-Bartmeyer, Barbara, Nikolopoulos, Georgios K., Paraskeva, D., Dudas, M., Briem, H., Sigmundsdottir, G., Igoe, D., O’Donnell, K., O’Flanagan, D., Suligoi, B., Konova, S., Erne, S., Caplinskiene, I., Jean-Schmit, C., Melillo, J. M., Melillo, T., Coul, E. Op De, Blystad, H., Rosinska, M., Diniz, A., Mardarescu, Mariana, Truska, P., Klavs, I., Diez, M., Avdicova, Maria, Delpech, Valerie, and Nikolopoulos, Georgios K.[0000-0002-3307-0246]
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Male ,Delayed Diagnosis ,Epidemiology ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Men who have sex with men ,Risk Factors ,Diagnosis ,Medical diagnosis ,media_common ,human immunodeficiency virus ,Transmission (medicine) ,Human immunodeficiency virus ,AIDS Serodiagnosis ,Homosexuality ,Emigration and Immigration ,Early diagnosis ,Cell count ,Virus diagnosis ,AIDS ,Europe ,Population Surveillance ,Public Health ,Human ,Adult ,medicine.medical_specialty ,Virus transmission ,Cd4+ t lymphocyte ,Acquired immunodeficiency syndrome (AIDS) ,Virology ,medicine ,media_common.cataloged_instance ,Humans ,European Union ,European union ,Homosexuality, Male ,Hiv surveillance ,HIV ,acquired immunodeficiency syndrome ,CD4 Lymphocyte Count ,Public Health, Environmental and Occupational Health ,business.industry ,Prevention ,Environmental and Occupational Health ,medicine.disease ,Immunology ,business ,Demography - Abstract
Human immunodeficiency virus (HIV) transmission remains significant in Europe. Rates of acquired immunodeficiency syndrome (AIDS) have declined, but not in all countries. New HIV diagnoses have increased among native and foreign-born men who have sex with men. Median CD4 + T-cell count at diagnosis has increased, but not in all groups, and late diagnosis remains common. HIV infection and AIDS can be eliminated in Europe with resolute prevention measures, early diagnosis and access to effective treatment. © 2015, European Centre for Disease Prevention and Control (ECDC). All rights reserved. 20 47
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- 2015
10. Second European multi-disciplinary conference of national strategies for Chlamydia trach. and human papillomavirus NSCP conf. in Berlin, 2013 enhanced detection, management and surveillance of sexually transmitted infections in Europe are essential!
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Ozolins, D., D' Elios, M. M., Ripa, T., Bailey, R., Timms, P., Spiteri, G., Haar, K., and Unemo, M.
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Male ,HPV ,Papillomavirus Infections ,Vaccination ,Sexually Transmitted Diseases ,Chlamydia trachomatis ,Chlamydia Infections ,Congresses as Topic ,Europe ,STI ,surveillance ,diagnostics ,vaccine ,conference ,Female ,Humans ,Mass Screening - Abstract
There is a need for updated guidance on detection, management and surveillance of sexually transmitted infections (STIs). Chlamydia, gonorrhoea and syphilisreporting needs to be mandatory in more European countries to aid collection of data. More widespread Chlamydia screening is needed in many countries as this is the only way to reduce complications. The role of Human Papillomavirus (HPV) screening in a situation where the prevalence of HPV infection has dropped significantly was also discussed in the context of the high cost of screening, the need for a relatively complex infrastructure, particularly in developing countries, and falling vaccination costs. An integrated HPV vaccination and screening policy could be the most appropriate with vaccination at 9-13 years as recommended by WHO and a single HPV screen at 35-39 years, possibly repeated thereafter every 10 years. Female and male HPV vaccination programmes could lead to near elimination of genital warts in both females and males. Surveillance of STIsshould be intensified where needed; additional or better quality data should be collected including reasons for testing, denominator data to estimate positivity rates, diagnostic methods, concurrent STIs, sexual orientation and country of acquisition; more analytical rather than descriptive epidemiology is needed.
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- 2013
11. Higher all-cause mortality in children during autumn 2009 compared with the three previous years: pooled results from eight European countries
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Mazick, A., Gergonne, B., Wuillaume, F., Danis, K., Apostolos Vantarakis, Uphoff, H., Spiteri, G., Klooster, T., Junker, C., Holmberg, M., and Molbak, K.
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Adult ,Adolescent ,Infant, Newborn ,Infant ,Middle Aged ,Europe ,Young Adult ,Cause of Death ,Child, Preschool ,Child Mortality ,Humans ,Registries ,Child ,Aged - Abstract
The paper describes weekly fluctuations of all-cause mortality observed in eight European countries during the period between week 27 and 51, 2009, in comparison with three previous years. Our preliminary data show that the mortality reported during the 2009 influenza pandemic did not reach levels normally seen during seasonal influenza epidemics. However, there was a cumulative excess mortality of 77 cases (1 per 100,000 population) in 5-14-year-olds, and possibly also among 0-4-year-olds.
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- 2010
12. WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014
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Jacobsson S, Golparian D, Cole M, Spiteri G, Martin I, Bergheim T, Maria José Borrego, Crowley B, Crucitti T, Ap, Dam, Hoffmann S, Jeverica S, Kohl P, Mlynarczyk-Bonikowska B, Pakarna G, Stary A, Stefanelli P, Pavlik P, Tzelepi E, and Abad R
13. SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers
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Stefano Porru, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Maria Diletta Pezzani, Giuseppe Lippi, Davide Gibellini, Evelina Tacconelli, Ilaria Dalla Vecchia, Emma Sala, Emanuele Sansone, Giuseppe De Palma, Carlo Bonfanti, Massimo Lombardo, Luigina Terlenghi, Enrico Pira, Ihab Mansour, Maurizio Coggiola, Catalina Ciocan, Alessandro Godono, Adonina Tardon, Marta-Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Francisco-Jose Jimeno-Demuth, Rafael-Vicente Castro-Delgado, Tania Iglesias Cabo, Maria Luisa Scapellato, Filippo Liviero, Angelo Moretto, Paola Mason, Sofia Pavanello, Anna Volpin, Luigi Vimercati, Silvio Tafuri, Luigi De Maria, Stefania Sponselli, Pasquale Stefanizzi, Antonio Caputi, Fabriziomaria Gobba, Alberto Modenese, Loretta Casolari, Denise Garavini, Cristiana D’Elia, Stefania Mariani, Francesca Larese Filon, Luca Cegolon, Corrado Negro, Federico Ronchese, Francesca Rui, Paola De Michieli, Nicola Murgia, Marco Dell’Omo, Giacomo Muzi, Tiziana Fiordi, Angela Gambelunghe, Ilenia Folletti, Dana Mates, Violeta Claudia Calota, Andra Neamtu, Ovidiu Perseca, Catalin Alexandru Staicu, Angelica Voinoiu, Eleonóra Fabiánová, Jana Bérešová, Zora Kľocová Adamčáková, Roman Nedela, Anna Lesňáková, Jana Holčíková, Paolo Boffetta, Mahsa Abedini, Giorgia Ditano, Shuffield Seyram Asafo, Giovanni Visci, Francesco Saverio Violante, Carlotta Zunarelli, Giuseppe Verlato, Porru, S, Monaco, Mgl, Spiteri, G, Carta, A, Pezzani, Md, Lippi, G, Gibellini, D, Tacconelli, E, Dalla Vecchia, I, Sala, E, Sansone, E, De Palma, G, Bonfanti, C, Lombardo, M, Terlenghi, L, Pira, E, Mansour, I, Coggiola, M, Ciocan, C, Godono, A, Tardon, A, Rodriguez-Suarez, Mm, Fernandez-Tardon, G, Jimeno-Demuth, Fj, Castro-Delgado, Rv, Iglesias Cabo, T, Scapellato, Ml, Liviero, F, Moretto, A, Mason, P, Pavanello, S, Volpin, A, Vimercati, L, Tafuri, S, De Maria, L, Sponselli, S, Stefanizzi, P, Caputi, A, Gobba, F, Modenese, A, Casolari, L, Garavini, D, D'Elia, C, Mariani, S, Filon, Fl, Cegolon, L, Negro, C, Ronchese, F, Rui, F, De Michieli, P, Murgia, N, Dell'Omo, M, Muzi, G, Fiordi, T, Gambelunghe, A, Folletti, I, Mates, D, Calota, Vc, Neamtu, A, Perseca, O, Staicu, Ca, Voinoiu, A, Fabiánová, E, Bérešová, J, Adamčáková, Zk, Nedela, R, Lesňáková, A, Holčíková, J, Boffetta, P, Abedini, M, Ditano, G, Asafo, S, Visci, G, Violante, F, Zunarelli, C, Verlato, G, Porru S., Monaco M.G.L., Spiteri G., Carta A., Pezzani M.D., Lippi G., Gibellini D., Tacconelli E., Dalla Vecchia I., Sala E., Sansone E., De Palma G., Bonfanti C., Lombardo M., Terlenghi L., Pira E., Mansour I., Coggiola M., Ciocan C., Godono A., Tardon A., Rodriguez-Suarez M.-M., Fernandez-Tardon G., Jimeno-Demuth F.-J., Castro-Delgado R.-V., Iglesias Cabo T., Scapellato M.L., Liviero F., Moretto A., Mason P., Pavanello S., Volpin A., Vimercati L., Tafuri S., De Maria L., Sponselli S., Stefanizzi P., Caputi A., Gobba F., Modenese A., Casolari L., Garavini D., D'Elia C., Mariani S., Filon F.L., Cegolon L., Negro C., Ronchese F., Rui F., De Michieli P., Murgia N., Dell'Omo M., Muzi G., Fiordi T., Gambelunghe A., Folletti I., Mates D., Calota V.C., Neamtu A., Perseca O., Staicu C.A., Voinoiu A., Fabianova E., Beresova J., Adamcakova Z.K., Nedela R., Lesnakova A., Holcikova J., Boffetta P., Abedini M., Ditano G., Asafo S.S., Visci G., Violante F.S., Zunarelli C., and Verlato G.
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Pharmacology ,health worker ,COVID-19 ,SARS-CoV-2 vaccination ,breakthrough infections ,health workers ,occupational and socio-demographic determinants ,Immunology ,breakthrough infection ,Infectious Diseases ,occupational and socio-demographic determinant ,Drug Discovery ,Pharmacology (medical) - Abstract
European Commission, H2020 [101016167]; Regional Health Authority (Azienda Zero), Veneto Region, Italy; Health Research Institute of Asturias (ISPA), Spain, Porru S, Monaco MGL, Spiteri G, Carta A, Pezzani MD, Lippi G, Gibellini D, Tacconelli E, Dalla Vecchia I, Sala E, Sansone E, De Palma G, Bonfanti C, Lombardo M, Terlenghi L, Pira E, Mansour I, Coggiola M, Ciocan C, Godono A, Tardon A, Rodriguez-Suarez MM, Fernandez-Tardon G, Jimeno-Demuth FJ, Castro-Delgado RV, Iglesias Cabo T, Scapellato ML, Liviero F, Moretto A, Mason P, Pavanello S, Volpin A, Vimercati L, Tafuri S, De Maria L, Sponselli S, Stefanizzi P, Caputi A, Gobba F, Modenese A, Casolari L, Garavini D, D'Elia C, Mariani S, Filon FL, Cegolon L, Negro C, Ronchese F, Rui F, De Michieli P, Murgia N, Dell'Omo M, Muzi G, Fiordi T, Gambelunghe A, Folletti I, Mates D, Calota VC, Neamtu A, Perseca O, Staicu CA, Voinoiu A, Fabiánová E, Bérešová J, Adamčáková ZK, Nedela R, Lesňáková A, Holčíková J, Boffetta P, Abedini M, Ditano G, Asafo SS, Visci G, Violante FS, Zunarelli C, Verlato G
- Published
- 2022
14. Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project
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Collatuzzo, Giulia, Visci, Giovanni, Violante, Francesco S, Porru, Stefano, Spiteri, Gianluca, Monaco, Maria Grazia Lourdes, Larese Fillon, Francesca, Negro, Corrado, Janke, Christian, Castelletti, Noemi, De Palma, Giuseppe, Sansone, Emanuele, Mates, Dana, Teodorescu, Silvia, Fabiánová, Eleonóra, Bérešová, Jana, Vimercati, Luigi, Tafuri, Silvio, Abedini, Mahsa, Ditano, Giorgia, Asafo, Shuffield S, Boffetta, Paolo, Zunarelli, Carlotta, Bonfiglioli, Roberta, Carta, Angela, Verlato, Giuseppe, Lippi, Giuseppe, Gibellini, Davide, Pezzani, Maria Diletta, Torroni, Lorena, Hoelscher, Michael, Wieser, Andreas, Reinkemeyer, Christina, Plank, Michael, Noreña, Ivan, Rubio-Acero, Raquel, Winter, Simon, Leustean, Mihaela, Perseca, Ovidiu, Ipate, Madalina, Agripina, Rascu, Strhársky, Jozef, Hellebrandt, Petra, Križanová, Daniela, Mrázová, Marianna, De Maria, Luigi, Sponselli, Stefania, Stefanizzi, Pasquale, Caputi, Antonio, Collatuzzo G., Visci G., Violante F.S., Porru S., Spiteri G., Monaco M.G.L., Larese Fillon F., Negro C., Janke C., Castelletti N., De Palma G., Sansone E., Mates D., Teodorescu S., Fabianova E., Beresova J., Vimercati L., Tafuri S., Abedini M., Ditano G., Asafo S.S., and Boffetta P.
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COVID-19 Vaccines ,vaccine, COVID – 19, serology, health care workers (HCW), immune response ,Health Personnel ,Immunology ,COVID – 19 ,Vaccination ,health care workers (HCW) ,Immunity ,immune response ,serology ,vaccine ,Infant ,COVID-19 ,Antibodies, Viral ,Antibodies ,Immunoglobulin G ,Immunology and Allergy ,Humans ,Female ,Viral ,Human - Abstract
BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs).MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses.ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (pConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.
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- 2022
15. Determinants of Anti-S Immune Response at 9 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project
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Giulia Collatuzzo, Vittorio Lodi, Daniela Feola, Giuseppe De Palma, Emanuele Sansone, Emma Sala, Christian Janke, Noemi Castelletti, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Filon, Corrado Negro, Luca Cegolon, Jana Beresova, Eleonora Fabianova, Lucia A. Carrasco-Ribelles, Pere Toràn-Monserrat, Marta Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Shuffield S. Asafo, Giorgia Ditano, Mahsa Abedini, Paolo Boffetta, Collatuzzo, G, Lodi, V, Feola, D, De Palma, G, Sansone, E, Sala, E, Janke, C, Castelletti, N, Porru, S, Spiteri, G, Monaco, Mgl, Larese Filon, F, Negro, C, Cegolon, L, Beresova, J, Fabianova, E, Carrasco-Ribelles, La, Toràn-Monserrat, P, Rodriguez-Suarez, Mm, Fernandez-Tardon, G, Asafo, S, Ditano, G, Abedini, M, and Boffetta, P.
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Infectious Diseases ,temporal trends ,antibody level ,temporal trend ,Virology ,COVID-19 ,vaccine ,serology ,immunization - Abstract
This project has received funding from the EU Horizon 2020 research and innovation program under the ORCHESTRA project Grant Agreement No. 101016167. The cohort from Verona is funded by the Regional Health Authority (Azienda Zero), Veneto Region, Italy., Collatuzzo G., Lodi V., Feola D., De Palma G., Sansone E., Sala E., Janke C., Castelletti N., Porru S., Spiteri G., Monaco M.G.L., Larese Filon F., Negro C., Cegolon L., Beresova J., Fabianova E., Carrasco-Ribelles L.A., Toràn-Monserrat P., Rodriguez-Suarez M.M., Fernandez-Tardon G., Asafo S.S., Ditano G., Abedini M., Boffetta P.
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- 2022
16. Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders
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Gianluca Spiteri, Eliana Finocchio, Salvatore Battaglia, Marcello Ferrari, Francesca Sanna, Nicola Murgia, Giuseppe Verlato, Leonardo Antonicelli, Pierpaolo Marchetti, Pietro Pirina, Angelo Corsico, Mario Olivieri, Francesca Locatelli, Roberta Vesentini, Roberto Bono, Finocchio E., Locatelli F., Sanna F., Vesentini R., Marchetti P., Spiteri G., Antonicelli L., Battaglia S., Bono R., Corsico A.G., Ferrari M., Murgia N., Pirina P., Olivieri M., and Verlato G.
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Male ,Non-allergic rhinitis ,Gastroesophageal reflux disease ,Gastroenterology ,Allergic rhinitis ,0302 clinical medicine ,Prevalence ,Non-allergic rhiniti ,030223 otorhinolaryngology ,Sinusitis ,Rhinitis ,Aged, 80 and over ,education.field_of_study ,Middle Aged ,Gastritit ,Italy ,Gastritis ,Gastroesophageal Reflux ,Female ,Public Health ,medicine.symptom ,Research Article ,Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Population ,Gastritits ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,NO ,Hiatal hernia ,Gastritits, Gastroesophageal refux disease, Allergic rhinitis, Non-allergic rhinitis, Sinusitis ,Young Adult ,03 medical and health sciences ,Internal medicine ,Allergic rhiniti ,medicine ,Humans ,Gastroesophageal refux disease ,education ,Aged ,lcsh:RC705-779 ,business.industry ,lcsh:Diseases of the respiratory system ,medicine.disease ,Rhinitis, Allergic ,Sinusiti ,digestive system diseases ,030228 respiratory system ,Relative risk ,Chronic Disease ,GERD ,Sinusitis, Public Health ,business ,Esophagitis - Abstract
BackgroundGastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.AimsTo evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.MethodsWe investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed “gastritis or stomach ulcer (confirmed by gastroscopy)” or “gastroesophageal reflux disease, hiatal hernia or esophagitis”. The association between NAR/AR/sinusitis and either gastritis or GERD was evaluated through relative risk ratios (RRR) by multinomial logistic regression.ResultsThe prevalence of gastritis/GERD increased from subjects without nasal disturbances (22.8% = 323/1414) to subjects with AR (25.8% = 152/590) and further to subjects with NAR (36.7% = 69/188) or sinusitis (39.9% = 276/691). When adjusting for centre, sex, age, education level, BMI, smoking habits and alcohol intake, the combination of gastritis and GERD was associated with a four-fold increase in the risk of NAR (RRR = 3.80, 95% CI 2.56–5.62) and sinusitis (RRR = 3.70, 2.62–5.23) with respect to controls, and with a much smaller increase in the risk of AR (RRR = 1.79, 1.37–2.35)..ConclusionThe study confirmed the association between gastritis/GERD and nasal disturbances, which is stronger for NAR and sinusitis than for AR.
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- 2021
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