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e20011 Background: Immunotherapy offers great promise for cancer treatmet. Strong evidence supports adoptive cell transfer (ACT) and immunemodulation for regression of advanced melanoma. Few studies assessed the potential synergy between these two strategies. Methods: Twelve patients with metastatic melanoma received multiple Melan-A/Mart-1-peptide vaccinations with (n=6) or without (n=6) IMP321 (LAG-3Ig fusion protein) as an adjuvant in combination with lymphodepleting chemotherapy and ACT. All patients were selected on the basis of ex vivo detectable Melan-A-specific CD8 T cell responses and were immunized at day (D) 0, 8, 15, 22, 28, 52, and 74 post-reinfusion. Results: One-week after reinfusion of bulk autologous PBMCs, a significant expansion of Melan-A-specific CD8 T cells was measured in >83% (n=5) and 2-, >4-, and >6-fold higher in the IMP321 group at D15, D30, and D60 (p=0.02). A long-lasting Melan-A-specific CD8 T-cell response was significantly associated with IMP321 (pEMRA (i.e., CD45RA+CCR7-CD127-) cells was observed in the IMP321 group at the peak of the response (p REGS); we observed a negative correlation between the fold increase of Melan-A-specific CD8 T cells and the relative expansion of TREGS. Clinical benefit (assessed as CR, PR, and SD) was observed in none of the control patients vs 67% (4/6) of patients from the IMP321 group, (p=0.02). Conclusions: Vaccination with IMP321 as an adjuvant in combination with lymphodepleting chemotherapy and ACT provided clinical benefit and this was associated with a more robust and durable cellular antitumor immune response, supporting further development of IMP321 for future immunotherapeutic strategies. Clinical trial information: NCT00324623.

We propose a quantitative and reversible method for tuning the charge localization of Au-stabilized stepped Si surfaces by site-specific hydrogenation. This is demonstrated for Si(553)-Au as a model system by combining density functional theory simulations and reflectance anisotropy spectroscopy experiments. We find that controlled H passivation is a two-step process: step edge adsorption drives excess charge into the conducting metal chain `reservoir' and renders it insulating, while surplus H recovers metallic behavior. Our approach illustrates a route towards microscopic manipulation of the local charge distribution within the surface structure and establishes a reversible switch of site specific chemical reactivity and magnetic properties on vicinal surfaces.

The adsorption of small organic molecules onto vicinal Au-stabilized Si(111) surfaces is shown to be a versatile route towards controlled growth of ordered organic-metal hybrid one-dimensional nanostructures. Density functional theory is used to investigate the site-specific adsorption of toluene-3,4-dithiol (TDT) molecules onto the clean Si(553)-Au surface and onto a co-doped surface whose steps are passivated by hydrogen. We find that the most reactive sites involve bonding to silicon at the step edge or on the terraces, while gold sites are relatively unfavored. H passivation and TDT adsorption both induce a controlled charge redistribution within the surface layer, causing the surface metallicity, electronic structure, and chemical reactivity of individual adsorption sites to be substantially altered.

The morphology, structure and phonon properties of well-aligned and kink-free GaAs nanowires grown on ((1) over bar(1) over bar(1) over bar )B GaAs are reported. The nanowires were grown at temperatures down to 400 degrees C by Au-catalysed MOVPE using (BuAsH2)-Bu-t and Me3Ga in H-2 ambient. Colloidal An nanoparticles (NPs) with average size of 60-70 nm were used as catalyst. Below 425 degrees C the nanowires consist of almost cylindrical segments, their average diameter closely matching that of the original Au NPs. At higher temperatures, the nanowires show a large tapering. The structural analysis of nanowire samples grown at 450 degrees C evidences that residual catalyst droplets at the nanowire tips consist of crystalline fcc Au, with a preferred (I 1 1) crystallographic orientation, and orthorhombic GaAu2 alloy (7 phase). Non-resonant Ramam scattering experiments carried out on GaAs nanowires showed no evidence of phonon confinement effects. However, new strong LO phonon contributions arise in the Raman spectra with respect to bulk GaAs, likely due to the nanowire large surface-to-volume ratio.

Made available in DSpace on 2015-09-17T15:25:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-27. Added 1 bitstream(s) on 2015-09-17T15:48:46Z : No. of bitstreams: 1 000846496.pdf: 1386882 bytes, checksum: 58b3bc36bd8f05aff6254f7cab14f6a6 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Esta dissertação apresenta o anel de inteiros de corpos quadráticos, de corpos ciclotômicos, de alguns subcorpos ciclotômicos e de corpos de números abelianos com o objetivo de utilizá-los na produção de reticulados algébricos, os quais são aplicados a teoria da Informação e a teoria dos Códigos Corretores de Erros. O texto desenvolve conceitos básicos sobre Álgebra e Teoria Algébrica dos Números, estuda bases integrais de corpos de n umeros sob dois diferentes aspectos, caracteriza o anel de inteiros dos corpos de números referidos anteriormente e apresenta algumas aplicações dessa teoria aos reticulados algébricos. Os teoremas centrais demonstrados nesta dissertação são o Teorema de Hilbert-Speiser e o Teorema de Leopoldt-Lettl. Este fornece o anel de inteiros de qualquer corpo de números abeliano, generalizando aquele. Esta dissertação possui um capítulo dedicado a demonstração do Teorema de Leopoldt-Lettl de maneira detalhada. Além disso, este trabalho faz uma análise sobre a monogênese de alguns anéis de inteiros e apresenta um contraexemplo de anel de inteiros não monogênico. O último capítulo e dedicado aos reticulados e mostra exemplos de reticulados algébricos construídos nos espaços de dimensões 2, 4, 6 e 8 via o homomorfismo de Minkowski em ideais de anéis de inteiros de corpos de números. O trabalho que originou esta dissertação consistiu principalmente na pesquisa e no detalhamento das demonstrações do Teorema de Leopoldt-Lettl e de três teoremas relacionados ao tema da monogênese de anéis de inteiros. Este empenho deu origem a um desenvolvimento mais claro e menos compacto das demonstrações relacionadas a esses assuntos, o qual e apresentado no texto. Enfim, este trabalho reúne e oferece um grande aparato teórico que tem sido útil ao desenvolvimento da teoria dos reticulados algébricos e que cria a expectativa de sua utilização em futuras aplicações This master thesis presents the rings of integers of quadratic elds, cyclotomic elds, some cyclotomic sub elds and abelian number elds aiming use them to produce algebraic lattices, which are applied in the Information Theory and in the Error Correcting Codes Theory. The text develops basic concepts about Algebra and Algebraic Number Theory, studies integral basis of number elds from two di erent perspectives, characterizes the ring of integers of the aforementioned number elds and presents some applications of this theory to algebraic lattices. The main proven theorems in this thesis are Hilbert-Speiser Theorem and Leopoldt-Lettl Theorem. The second provides the ring of integers of any abelian number eld, generalizing the rst. This thesis has a chapter dedicated to make the proof of the Leopoldt-Lettl Theorem in detail. Furthermore, this work analyses the monogenesis of some ring of integers and presents a counterexample of a ring of integers non-monogenic. The last chapter is aimed at lattices and shows examples of algebraic lattices in spaces of dimensions 2, 4, 6 and 8 constructed by ideals of ring of integers of number elds through Minkowski homomorphism. The work that created this thesis consisted mainly in research and detailing of the proofs of Leopoldt- Lettl Theorem and of three theorems linked to the issue of monogenesis of the ring of integers. This e ort created a development lighter and less compact of the proofs related to these subjects, which is presented in the text. Finally, this thesis gathers and provides a great theoretical apparatus that has been useful to development of the theory of algebraic lattices and that creates the expectation of its use in future applications in this area

With ongoing instrumental improvements Raman spectroscopy (RS) is advancing into the study of surface vibrational modes of semiconductors. On compound semiconductors, like the IIIV's, two distinct types of surface modes occur, microscopic modes being vibrations confined to the surface and macroscopic modes penetrating much deeper into the bulk, dependent on the electromagnetic boundary conditions. Both mode types depend on surface properties, the microscopic ones on the atomic scale, and the macroscopic ones on the scale of the surface polariton wavelength. While the former one delivers surface atomic structure information, the latter one may be useful for instance to study the morphology of surfaces, such as the shape of semiconductor nanowires. We discuss Raman spectra obtained on the atomically well-defined III-V(110) model surfaces and recent results obtained on isolated III-V nanowires. The comparison of both gives insight in the capabilities of Raman scattering from surface phonons: The contributions of surface phonons, surface resonances, and macroscopic modes (Fuchs-Kliewer modes, surface phonon polaritons) to the Raman spectra become evident. (C) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

The inner composition, defect content and morphology of AlGaAs nanowires (NWs) grown on (111)B-GaAs by Au-catalyzed MOVPE is reported. The NWs grow tapered with their [111] axis normal to the substrate. The Raman spectra of single AlGaAs NWs were measured in non-resonant conditions with sub-μ-meter spatial resolution, allowing determination of the Al content. NWs consist of GaAs for TGG >475°C, namely an AlxGa1-xAs core surrounded by an AlyGa1-yAs (yG=500÷525°C) to almost hexagonal (for TG=550°C), due to an exchange between $\left\{ {\bar 211} \right\}$ and {110} planes as the slowest to grow. The NWs have free-electron concentrations ∼1018 cm-3, due to Si contamination of the Al source.

The stoichiometry of single ternary III-V semiconductor nanowires was analyzed by Raman spectroscopy. Free-standing AlxGa1-xAs nanowires were obtained through metal organic vapor phase epitaxy (MOVPE) by the vapor liquid solid (VLS) mechanism on GaAs substrates. The as-grown nanowires were studied with a scanning confocal Raman spectrometer (spatial resolution approximate to 300 nm). They were located by Rayleigh imaging and individual nanowires selected for Raman spectroscopy. The acquired spectra exhibit 2-mode behavior. The stoichiometry of single nanowires was determined based on the frequencies of the GaAs- and AlAs-like transversal optical (TO) and longitudinal optical (LO) peaks with an accuracy of below 10%. Measurements at different positions along the axis revealed variations of the composition within single nanowires. This non-uniformity evidences that the nanowires possess an internal structure.

for planetary landing missions," TR 32-231, Jet Propulsion Lab., Pasadena, Calif. (May 1, 1962). 3 Speiser, E. W., "Performance of nuclear-electric propulsion systems in space exploration," TR 32-159, Jet Propulsion Lab., Pasadena, Calif. (December 15, 1961). 4 Stearns, J. W., "Electric propulsion requirements for planetary and interplanetary spacecraft," TR 32-403, Jet Propulsion Lab., Pasadena, Calif, (to be published). 5 Hayes, R. J., Hoffman, M. A., and Stuhlinger, E., "The manned electric rocket challenge," Preprint 2222-61, ARS Space Flight Report to the Nation, New York (October 1961). 6 Melbourne, W. G. and Sauer, C. G., "Optimum thrust programs for power-limited propulsion systems," TR 32-118, Jet Propulsion Lab., Pasadena, Calif. (June 15, 1961). 7 Volkoff, J. J., "Protection requirements for the resistance of meteorite penetration of interplanetary spacecraft systems," TR 32-410, Jet Propulsion Lab., Pasadena, Calif, (to be published). 8 Davis, J. P., "A nuclear reactor concept for electric propulsion application," TR 32-385, Jet Propulsion Lab., Pasadena, Calif. (March 4, 1963).

part (Nos. 120-359), containing placenames of North Syria. About 170 names are extant out of the original 270, but only a few of them have been identified so far because of scarcity of comparative ancient material.3 A decade ago, the epigraphical results of the excavation of Alalah were published by Sidney Smith 1 Abbreviations of works quoted: Albright = W. F. Albright, The Vocalization of the Egyptian Syllabic Orthography (American Oriental Series, vol. 5 [New Haven 1934]). Albright-Lambdin = W. F. Albright and T. O. Lambdin, "New Material for the Egyptian Syllabic Orthography," JSS, II (1957), 113-127. ANET = J. B. Pritchard (editor), Ancient Near Eastern Texts Relating to the Old Testament (2d ed., Princeton 1955 [Egyptian texts translated by John A. Wilson, Hittite texts by Albrecht Goetze]). Badawi = A. Badawi, "Die neue historische Stele Amenophis II." Annales du service des antiquitds de l'lgypte, XLII (1943), 1-23. BL = Bibel-Lexikon, ed. by Herbert Haag and A. Van den Born (Zxirich-Cologne, 1951). Breasted = James Henry Breasted, Ancient Records of Egypt (Chicago, 1906). Dussaud = Rene Dussaud, Topographie historique de la Syrie antique et mddidvale (Paris, 1927). Forrer = Emil Forrer, Die Provinzeinteilung des assyrischen Reiches (Leipzig, 1920). Gordon = Cyrus H. Gordon, Ugaritic Manual (Analecta Orientalia, 35 [Rome, 1935]). Honigmann, HT = Ernst Honigmann, "Historische Topographie von Nordsyrien im Altertum," ZDPV, XLVI (1923), 149-193, XLVII (1924), 1-24. Honigmann. PW = Ernst Honigmann, "Syria," PW, IV-A, II (1932), col. 1549-1727. J. Lewy = Julius Lewy, "Studies in the Historic Geography of the Ancient Near East," II, Orientalia, NS, XXI (1952), 265-92, 393-425. Kraeling = Emil G. H. Kraeling, Aram and Israel (New York, 1918). Luckenbill = Daniel D. Luckenbill, Ancient Records of Assyria and Babylonia (Chicago, 1926-1927). Maspero = Gaston Maspero, History of Egypt, Chaldea, Syria, Babylonia, and Assyria. Ed. by A. H. Sayce (London, 1903 and ss.). Miiller = W. Max Muiller, Asien und Europa nach altlgypti8chen Denkmnilern (Leipzig, 1893). Miiller (in epigraphical collations and emendations) = W. Max Miller, Egyptological Researches, I (Washington, 1906). NPN = Ignace J. Gelb, Pierre M. Purves, and Allan A. MacRae, Nuzi Personal Names (Chicago, 1943). PRU = Le palais royal d'Ugarit (Vol. II, by Charles Virolleaud: Vols. III and IV, by Jean Nougayrol) [Paris, 1955-1957]. P W = Pauly-Wissowa, Realencyclopddie der classischen Altertumswissenschaft (Stuttgart, since 1894). RLA = Reallexikon der Assyriologie (Berlin, 1932 and ss.). Sethe = Kurt Sethe, Urkunden der 18. Dynastie, II (Berlin, 1906). Simons = J. Simons, Handbook for the Study of Egyptian Topographical Lists Relating to Western Asia (Leiden, 1937). S. Smith = Sidney Smith, The Statue of Idri-mi (London, 1949). Speiser = E. A. Speiser, Introduction to Hurrian (AASOR, Vol. XX [New Haven, 1941]). Wiseman = D. J. Wiseman, The Alalakh Tablets (London, 1953). 2 "Thutmes III's famous Karnak lists.., .in contrast to all other and later lists.. . alone are uni