1. ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in non-valvular atrial fibrillation (RAMSES study)
- Author
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Özcan Başaran, Mehmet Yaman, Ahmet Çağrı Aykan, Mehmet Tekinalp, Ibrahim Altun, Volkan Doğan, Macit Kalçık, Özgen Şafak, Osman Beton, Onur Taşar, Murat Biteker, Ezgi Kalaycıoğlu, Ismail Bolat, Mustafa Özcan Soylu, Cevat Kirma, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, Biteker, Murat, [Basaran, Ozcan -- Dogan, Volkan -- Altun, Ibrahim -- Soylu, Mustafa Ozcan -- Biteker, Murat] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Fethiye, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey, Demir, Vahit -- 0000-0001-8349-6651, and BASARAN, OZCAN -- 0000-0002-6384-6455
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medicine.medical_specialty ,Turkey ,Non valvular atrial fibrillation ,Administration, Oral ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,prevention ,Risk Factors ,Internal medicine ,Surveys and Questionnaires ,Atrial Fibrillation ,medicine ,Humans ,Oral Anticoagulant Therapy ,Medical history ,030212 general & internal medicine ,Stroke ,Aged ,Aged, 80 and over ,Mitral regurgitation ,Univariate analysis ,business.industry ,Prevention ,Hot Topic ,Anticoagulants ,Atrial fibrillation ,oral anticoagulant therapy ,Middle Aged ,medicine.disease ,stroke ,Cross-Sectional Studies ,Stroke prevention ,Multicenter survey ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS: 000392195800004, PubMed ID: 27723665, Objective: Data regarding stroke prevention strategies in non-valvular atrial fibrillation (NVAF) are limited to vitamin K antagonists (VKAs). This study aimed to evaluate real-life stroke prevention strategies for NVAF patients in the era of non-VKA oral anticoagulants (NOACs). Methods: We established a cross-sectional, multicenter, nationwide registry of NVAF patients. All consecutive atrial fibrillation (AF) patients and without mechanical heart valves or rheumatic mitral stenosis (but including those with any degree of mitral regurgitation) were enrolled in the ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies (RAMSES Study; ClinicalTrials. gov identifier NCT02344901) in Turkey. Base-line demographic data, medical history, and medications prescribed for NVAF treatment were collected. Univariate analyses were performed for continuous variables, and the chi-square test was used for categorical variables. Results: In total, 6273 patients from 29 provinces of Turkey were enrolled in the study between February and May 2015, with the contribution of 83 investigators. The mean age was 69.6 +/- 10.7 years; 56% of the patients were females, and one-fifth of the patients had at least one comorbid disease, the most common being hypertension (69%). The mean CHA(2)DS(2)-VASc and HAS-BLED scores were 3.3 +/- 1.6 and 1.6 +/- 1.1, respectively. The rate of oral anticoagulant (OAC) therapy use was 72% (37% NOAC and 35% VKA). Conclusion: The RAMSES study showed a higher prevalence of OAC use among NVAF patients than that reported in previous studies. Although NOACs were preferred over VKAs in daily cardiology practice, there is a need for improved OAC therapies for NVAF patients.
- Published
- 2016