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The research on perceived expectations for active aging (PEAA) has to date highlighted several of their positive outcomes, such as better psychological adjustment in the young-old adults who do not work or volunteer (Pavlova & Silbereisen, 2016), and more positive change in caregiving frequency over 1 year (see https://osf.io/b3k4c). In the present research, we aim to understand the implications of PEAA for well-being further by examining the change in general and domain-specific well-being indicators over time in adults of all ages. Furthermore, we will test whether age stereotypes and resources combined with motivation moderate this relationship, as those who are more motivated and resourceful and hold more positive views on aging may experience higher well-being if they perceive higher expectations for active aging. To this end, we will utilize longitudinal data from several waves of the Innovation Sample (N = 2,007, aged 16-94) of the German Socio-Economic Panel (SOEP-IS).

Perceived expectations for active aging (PEAA) improve psychological adjustment in young-old adults who do not volunteer or work (Pavlova & Silbereisen, 2016), but their benefits may also manifest in different types of activities. In our previous study, we showed that PEAA and their positive appraisal predicted high (vs. no) frequency of caregiving one year later in young-old German adults (see https://osf.io/b3k4c). However, as age stereotypes and preparation for age-related changes are strongly implicated in one’s aging process (Kornadt et al., 2015, 2017), their role in the effects of PEAA on activities should be considered. In the present study, we aim to investigate whether the domain-specific relationship between PEAA and activities is mediated by age stereotypes and preparation for age-related changes in German adults of all ages. To this end, we will employ longitudinal data from the Innovation Sample (N = 2,007, aged 16-94) of the German Socio-Economic Panel (SOEP-IS).

Previously, perceived expectations for active aging (PEAA) were shown to predict better psychological adjustment among young-old German adults (56-75) who were not working or volunteering (Pavlova & Silbereisen, 2016). More recently, we showed that PEAA in the social engagement domain as well as the challenge appraisal of overall PEAA predicted high (vs. no) frequency of caregiving one year later in young-old German adults (see https://osf.io/b3k4c). However, resources and motivation relevant to active aging were more predictive of subjective perceptions of aging and productive activities than PEAA. Furthermore, age stereotypes may be an important factor in the relationship between PEAA and activities (i.e., benefits of PEAA may accrue to those who hold more positive attitudes towards older age). In the present study, we aim to investigate the domain-specific relationships between PEAA and activities and see whether these effects are moderated by age stereotypes as well as resources and motivation (combined into domain-specific indices). To this end, we will use longitudinal data from the Innovation Sample (N=2,007, aged 16-94) of the German Socio-Economic Panel (SOEP-IS).

Perceived expectations for active aging (PEAA) have been shown to predict better psychological adjustment in nonworking individuals and nonvolunteers (Pavlova & Silbereisen, 2016). Given the recent evidence suggesting that PEAA are domain-specific (Pavlova et al., 2022) and that personal resources, individual motivation, and secondary appraisal play an important role in PEAA (see https://osf.io/24pw8 and https://osf.io/8rud5), further investigation of their outcomes is warranted. The aim of the current study is to examine the effects of individual resources, motivation, and appraisals of PEAA (i.e., as a threat or a challenge) on the domain-specific relationship between PEAA (conceptualized as perceived growth in the expectations for active aging, in the domains of physical and mental health and social engagement), subjective aging perceptions, and productive activities over one year. To this end, we will utilize two waves of survey data from the Jena Study on Social Change and Human Development from a sample of young-old Germans (aged 56-75 at baseline).

While there is evidence that sociodemographic variables and socioeconomic resources play a (minor) role in perceived expectations for active aging (PEAA), no research has examined the role of psychological variables in PEAA. In this study, we want to investigate whether the psychological characteristics of individuals and the people in their immediate (i.e., household) environment predict PEAA in the domains of physical health, mental health, and social engagement. Psychological characteristics include motivational variables (life goals and health/dementia worries), selected personality traits (conscientiousness, openness to experience, extraversion, and optimism), and domain-specific age stereotypes (at the household level only). We will use cross-sectional data from the 2016 wave of the Innovation Sample of the German Socio-Economic Panel (SOEP-IS).

Items to assess civic and political participation from the survey “Local environment, individual developmental assets, and local potential for civic participation” (PIs: Everhard Holtmann, Rainer K. Silbereisen).

Recent evidence suggests that certain socioeconomic and health resources are associated with perceived expectations for active aging (PEAA) in a domain-specific or domain-general way (Pavlova et al., in press). Moreover, individual motivations and other psychological variables appeared to contribute to PEAA more than objective or external factors such as SES or characteristics of household members (Radoš et al., in preparation). However, it is unclear whether individual motivations and psychological resources can also predict change in domain-specific PEAA over time and what is the role of motivations and resources in appraising overall (i.e., not domain-specific) PEAA as a threat or a challenge (secondary appraisals). The objectives of the current study are to investigate (a) whether individual motivations and personal and social resources predict change in domain-specific (i.e., physical and mental health, social engagement) PEAA over one year, and (b) whether the combination of motivation and different types of individual resources (socioeconomic, health, personal, and social) predict change in the appraisal of overall PEAA (i.e., as a threat or a challenge) over one year. This study will also serve as a conceptual replication of parts of our parallel study on a different sample (https://osf.io/24pw8). To these ends, we will utilize two waves of survey data from the Jena Study on Social Change and Human Development from a sample of young-old Germans (aged 56-75 at baseline).

Exposure to expectations for active aging may be modulated by age and individual resources (socioeconomic status, social integration, and health) via multiple pathways. Using a cross-sectional, nationally representative sample of adults aged 17 to 94 ( N = 2,007), we investigated the relations between age, individual resources, and perceived expectations for active aging (PEAA) in three domains (physical health, mental health, and social engagement). Across domains, young adults and individuals aged 70+ reported slightly lower PEAA than emerging adults did; no other age differences emerged. Multiple regression showed that a higher subjective socioeconomic status, better perceived general health, and partnership (in older adults) predicted higher PEAA (almost) across domains, whereas church attendance, employment status, and occupational prestige yielded domain- and age-specific effects, which were not always positive. We conclude that the effects of individual resources on PEAA are limited in general but vary depending on life domain and age.

This research note addresses the current and potential future role of psychologists in the study of international migration. We review ways in which psychologists have contributed to the study of migration, as well as ways in which psychological scholarship could be integrated with work from other social science fields. Broadly, we discuss four major contributions that psychology brings to the study of international migration—studying migrants’ internal psychological experiences, incorporating a developmental perspective, conducting experimental studies, and integrating across levels of analysis. Given the position of psychology as a ‘hub science’ connecting more traditional social sciences with health and medical sciences, we argue for a more prominent role for psychologists within the study of international migration. Such a role is intended to complement the roles of other social scientists and to create a more interdisciplinary way forward for the field of migration studies. The research note concludes with an agenda for further scholarship on migration.

The emergence of high-throughput technologies for the comprehensive measurement of biomolecules, also referred to as "omics" technologies, has helped us gather "big data" and characterize microbial communities. In this article, we focus on metaproteomic and metabolomic approaches that support hypothesis-driven investigations on various oral biologic samples. Proteomics reveals the working units of the oral milieu and metabolomics unveils the reactions taking place; and so these complementary techniques can unravel the functionality and underlying regulatory processes within various oral microbial communities. Current knowledge of the proteomic interplay and metabolic interactions of microorganisms within oral biofilm and salivary microbiome communities is presented and discussed, from both clinical and basic research perspectives. Communities indicative of, or from, health, caries, periodontal diseases, and endodontic lesions are represented. Challenges, future prospects, and examples of best practice are given.

Kindernotfalle sind eine seltene, aber herausfordernde Einsatzindikation im Rettungseinsatz. Durch spezielle Krankheitsbilder im Kindesalter, die besondere kindliche Anatomie sowie die Notwendigkeit der gewichtsadaptierten Dosierung von Medikamenten muss der Notarzt bei der Behandlung von Kindern eine besondere kognitive Aufgabe meistern und sich einer hohen emotionale Belastung stellen. Im Notfall konnen standardisierte Algorithmen ein strukturiertes diagnostisches und therapeutisches Vorgehen erleichtern. Ziel dieser Arbeit ist es, eine standardisierte Vorgehensweise fur die haufigsten Kindernotfalle zu vermitteln. In Deutschland zahlen Atemwegsnotfalle, Krampfanfalle und Analgesie nach Trauma oder Verbruhungen zu den haufigsten Einsatzindikationen. Im Folgenden werden praktische diagnostische und therapeutische Tipps fur diese Notfallsituationen dargestellt.

Supplemental material, sj-docx-1-ahd-10.1177_00914150221112294 for Age, Individual Resources, and Perceived Expectations for Active Aging: General and Domain-Specific Effects by Maria K. Pavlova, Sonja Radoš, Klaus Rothermund and Rainer K. Silbereisen in The International Journal of Aging and Human Development

The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis. Marmara Üniversitesi ; Janggen-Pöhn-Stiftung ; Karolinska Institutet

Increasingly, adolescents are growing up in multiethnic multicultural societies. While intergroup prejudice can threaten the multicultural societal cohesion, intergroup friendships are strong predictors of reduced prejudice. Thus, more research is needed to fully understand the development of intergroup friendships and their relations to less prejudicial attitudes. This study addressed two major developmental research questions: first, whether longitudinal patterns of intergroup friendships of native adolescents (i.e., whether or not a native German adolescent has a friendship with an immigrant at different points in time) relate to changes in rates of prejudice about immigrants. Second, whether these friendship patterns that unfold over time can be predicted by contact opportunities, attitudes, subjective norms, and perceived behavioral control assessed at the beginning of the study. The sample included 372 native German adolescents (14.7years of age at first assessment, 62.3% girls) who showed one of four friendship trajectories over the three annual assessments: they either maintained, gained, never had, or lost a friendship with an outgroup peer. In particular, results showed that adolescents who gained an intergroup friendship over the three time points showed a significant decrease in negative prejudice over the study. All four theorized predictors contributed to explain friendship trajectory membership. Generally, adolescents with many opportunities for contact, positive attitudes about contact, perceived positive social norms for contact, and high levels of behavioral control (self-efficacy) were more likely to maintain a friendship with an outgroup member than to follow any of the three other friendship trajectories (gain, lost, or never had). The pattern of predictions differed, however, depending on the specific pairs of friendship trajectories compared.

Background Menopause, the absence of ovarian sex steroids, is frequently accompanied by emotional and physiological changes in a woman´s body, as well as oral health changes. The present study aimed to evaluate the association between the periodontal health status and emotional and physical well-being among postmenopausal women (PMW) in comparison with regularly menstruating premenopausal women (RMPW). Methods A total of 115 women (PMW, n = 56, mean age ± SD: 54 ± 5; RMPW, n = 59, mean age ± SD: 41 ± 4) received a comprehensive medical assessment and a full-mouth oral examination. All completed the Women’s Health Questionnaire (WHQ) to measure emotional and physical well-being. The corresponding bone mineral density (BMD) scores were obtained from participants´ medical records. Results Tooth loss was significantly higher in PMW than RMPW after adjusting for age (3.88 ± 2.41 vs 2.14 ± 2.43, p p > 0.05). The prevalence of periodontitis was associated with fewer daily brushing sessions in PMW (p = 0.021). Based on the WHQ, both PMW and RMPW with periodontitis had higher ‘’depressed mood’’ scores compared to periodontally healthy women (p = 0.06 and p = 0.038, respectively). The women who reported fewer daily toothbrushing sessions found to have higher depressive mood scores (p = 0.043). Conclusions Presence of periodontitis is associated with the emotional and physical well-being of women and reinforcement of oral healtcare is recommended at different stages of a woman’s life including menopause to reduce the risk for early tooth loss in women.

Introduction: Peptidoglycan recognition protein 1 (PGLYRP1), a member of peptidoglycan recognition proteins, is known to be involved in the proinflammatory response toward bacterial infections. Recently, PGLYRP1 was identified as a ligand for triggering receptor expressed on myeloid cells 1 (TREM-1). Although PGLYRP1 is involved in immune and inflammatory responses, its levels in initial stages of periodontal disease in adolescents are currently unknown. Objectives: We aimed to investigate salivary levels of PGLYRP1 and its correlation with TREM-1, polymorphonuclear leukocyte elastase (PMN elastase), and an active matrix metalloproteinase 8 (aMMP-8) in adolescents. Methods: Whole saliva samples (n = 537) were collected from 15- to 16-y-old adolescents at Kotka Health Center, Finland, prior to periodontal examination, including measurement of periodontal pocket depth (PPD), visible plaque index (VPI), and bleeding on probing (BOP). Adolescents, clustered as periodontally healthy, gingivitis, or subclinical periodontitis, were tested for salivary levels of TREM-1, PGLYRP1, and PMN elastase by enzyme-linked immunosorbent assay and aMMP-8 by a time-resolved immunofluorometric assay (IFMA). Results: Salivary levels of PGLYRP1 and aMMP-8 were significantly higher in adolescents with subclinical periodontitis and gingivitis compared to individuals with healthy periodontium. TREM-1 and PMN elastase levels were higher in adolescents with subclinical periodontitis compared to healthy individuals but did not reach significance. PGLYRP1 correlated positively with BOP, PPD, VPI, aMMP-8, and TREM-1. Conclusions: Elevated PGLYRP1 levels in adolescents with gingivitis and subclinical periodontitis and its positive correlation with TREM-1 and aMMP-8 may indicate an association of PGLYRP1 with initial stages of periodontal disease. Sex and poor oral hygiene but not smoking are also associated with higher levels of PGLYRP1. However, PGLYRP1 has a lower discriminating capacity and is therefore a less reliable marker alone in the diagnosis of initial stages of periodontal disease in adolescents. Knowledge Transfer Statement: PGLYRP1, a member of peptidoglycan recognition proteins, is a ligand for TREM-1. Elevated PGLYRP1 levels in adolescents with gingivitis and subclinical periodontitis and its positive correlation with TREM-1 and aMMP-8 may indicate an association of PGLYRP1 with initial stages of periodontal disease. However, it has a lower discriminating capacity and is therefore a less reliable marker alone in the diagnosis of periodontal disease in adolescents.

BACKGROUND This cross-sectional study aims to investigate if a point-of-care (PoC) test of active matrix metalloproteinase-8 (aMMP-8) predicts levels of inflammation amplifier triggering receptor expressed on myeloid cells-1 (TREM-1) and its putative ligand the neutrophil peptidoglycan recognition protein 1 (PGLYRP1) in saliva. METHODS Forty-seven adolescents, aged 15 to 17 years, were tested with aMMP-8 PoC test, which was followed by a full-mouth clinical examination of the assessment of periodontal, mucosal, and oral health. TREM-1 and PGLYRP1 levels were analyzed by ELISA. The immunofluorometric assay (IFMA) specific for aMMP-8 was used as the reference method. RESULTS Fourteen saliva samples out of a total of 47 showed positivity for aMMP-8 PoC test. Both the TREM-1 and the aMMP-8 (IFMA) levels were significantly elevated among the aMMP-8 PoC test positives compared with the PoC test negatives (P

Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. Research design and methods: Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Mouthrinse samples (pre-radiotherapy, after 6 weeks of radiotherapy and 1 month after radiotherapy) were assayed by aMMP-8 point-of-care-kit (PerioSafe (R)/ORALyzer (R)) for aMMP-8 and ELISA for IL-6. Results: HNC radiotherapy had a deteriorating impact on the periodontium and a significant impact on periodontal biomarkers aMMP-8 and IL-6 and increased their levels in mouthrinse. Clinical-attachment-loss (CAL) (site of greatest loss: mean = 1.7 mm, range = 1-3 mm) corresponding to rapid progression of periodontitis. There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. Conclusions: Elevated aMMP-8 levels were observed 1 month after radiotherapy among some HNC patients suggesting a prolonged increased susceptibility to further periodontal tissue destruction. Currently available aMMP-8 point-of-care testing could be useful to monitor and assess quantitatively online and real-time the risk of deterioration of periodontal health during HNC radiotherapy.

Drawing on the theory of planned behavior (TPB) and the volunteer process model (VPM), we compared proximal (the TPB variables) and distal (general social support and sense of community) antecedents and quality of experience between civic (CP) and political (PP) participation. Outcome variables were future intentions. We used data from a mail survey of 3,231 adults with or without prior CP or PP experience. Both inexperienced and experienced individuals perceived PP more negatively than CP. Quality of experience was also rated substantially more negatively for PP than for CP. Distal antecedents had similar effects for CP and PP, but they were mostly significant for CP only. In line with the VPM, quality of experience was the strongest predictor of future intentions in experienced individuals. Perceived behavioral control was the strongest mediator. Findings corroborate the distinction between CP and PP and suggest that PP is much less attractive on average.

Aim This study aimed to characterize the salivary proteome during the induction and resolution of gingival inflammation in the course of human experimental gingivitis (EG), and to cluster the proteomic profiles based on the clinically defined "slow" and "fast" response patterns. Materials and Methods A total of 50 unstimulated whole saliva were obtained from the EG model which was induced over 21 days (days 0, 7, 14 and 21), followed by a two-week resolution phase (day 35). Label-free quantitative proteomics using liquid chromatography-tandem mass spectrometry was applied. Regulated proteins were subject to Gene Ontology enrichment analysis. Results A total of 804 human proteins were quantified by >= 2 peptides. Principal component analysis depicted significant differences between "fast" and "slow" responders. Despite gingival and plaque scores being similar at baseline among the two groups, "fast" responders presented with 48 proteins that were at > 4-fold higher levels than "slow" responders. These up-regulated proteins showed enrichment in "antigen presentation" and "proteolysis." Conclusions Together, these findings highlight the utility of integrative systems-level quantitative proteomic approaches to unravel the molecular basis of "salivary proteotypes" associated with gingivitis dubbed as "fast" and "slow" responders. Hence, these differential responses may help prognosticate individual susceptibility to gingival inflammation., Journal of Clinical Periodontology, 47 (11), ISSN:0303-6979, ISSN:1600-051X

Background Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)-1? and calprotectin are associated with CF or reflect concomitant gingival inflammation. Methods Ten CF (age:3-12yrs) and ten systemically healthy age-and-gender-matched children (C) were enrolled in the study. Individuals with CF underwent routine laboratory determinations. Probing pocket depth (PPD), gingival index (GI), plaque index (PI) and bleeding on probing (BOP) were recorded on fully erupted teeth and saliva samples collected. Salivary TREM-1, PGLYRP1, IL-1? and calprotectin were analysed by ELISA. Results Children with CF had significantly higher BOP scores (P = 0.001) and calprotectin levels (P = 0.017) compared to the C group. TREM-1, PGLYRP1 and IL-1? could not distinguish between CF and SH but showed positive correlation with GI, PI and BOP in both groups. Calprotectin levels positively correlated with procalcitonin (P = 0.014), thrombocyte counts (P = 0.001), mean platelet volume (P = 0.030) and with PGLYRP1 (P = 0.019) and IL-1? (P = 0.013) in CF children. Receiver operating characteristic curve analysis for calprotectin (CFvsC) showed an area under the curve of 0.79 (95% CI 0.58-0.99, P = 0.034). Conclusions CF children presented with higher gingival inflammation scores and salivary calprotectin levels, that correlated with systemic inflammatory markers. Salivary calprotectin levels were not associated with periodontal parameters. Hence, preliminary data demonstrate that salivary calprotectin might have a chairside diagnostic potential for CF in children. This article is protected by copyright. All rights reserved

Purpose: This study aims to validate label-free quantitative proteomics (LFQ) against antibody-based methods for quantifying established periodontal disease biomarkers in saliva. Experimental Design: In an experimental gingivitis model, healthy volunteers (n = 10) provide saliva at baseline (d0), during the induction (d7, d14, d21) and resolution (d35) of gingival inflammation (total n = 50). Biomarker levels are analyzed by LFQ and time-resolved immunofluorometric assay (IFMA) or enzyme-linked immunosorbent assay (ELISA). Molecular matrix metalloproteinase (MMP)-8 forms are assessed by Western blot (WB) analysis. Results: LFQ detects significantly (p < 0.05) elevated MMP-8 (d21vsd7, d35vsd7) and tissue inhibitor of matrix metalloproteinases (TIMP)-1 (d35vsd7). Latent MMP-8 (70–80 kDa) is present (d0–d35), but not active MMP-8 (50–60 kDa). LFQ and immunoassay data significantly correlate for MMP-8 (r = 0.36), myeloperoxidase (r = 0.39), polymorphonuclear leukocyte elastase (r = 0.33), and TIMP-1 (r = −0.24). Conclusion and Clinical Relevance: LFQ can quantify enzyme levels in saliva, however lacks the ability to measure enzymatic activity. WB analysis reveals that MMP-8 may not be activated during induction of gingival inflammation. Significant but weak correlations between IFMA or ELISA and LFQ suggest a limited capacity of available antibodies to reliably quantify salivary biomarkers for periodontal diseases. Novel “anti-peptide” antibodies designed by newer targeted mass spectrometry-based approaches can help to overcome these drawbacks.

This research note addresses the current and potential future role of psychologists in the study of international migration. We review ways in which psychologists have contributed to the study of migration, as well as ways in which psychological scholarship could be integrated with work from other social science fields. Broadly, we discuss four major contributions that psychology brings to the study of international migration—studying migrants’ internal psychological experiences, incorporating a developmental perspective, conducting experimental studies, and integrating across levels of analysis. Given the position of psychology as a ‘hub science’ connecting more traditional social sciences with health and medical sciences, we argue for a more prominent role for psychologists within the study of international migration. Such a role is intended to complement the roles of other social scientists and to create a more interdisciplinary way forward for the field of migration studies. The research note concludes with an agenda for further scholarship on migration.

Background This cross-sectional study aims to investigate if a point-of-care (PoC) test of active matrix metalloproteinase-8 (aMMP-8) predicts levels of inflammation amplifier triggering receptor expressed on myeloid cells-1 (TREM-1) and its putative ligand the neutrophil peptidoglycan recognition protein 1 (PGLYRP1) in saliva. Methods Forty-seven adolescents, aged 15 to 17 years, were tested with aMMP-8 PoC test, which was followed by a full-mouth clinical examination of the assessment of periodontal, mucosal, and oral health. TREM-1 and PGLYRP1 levels were analyzed by ELISA. The immunofluorometric assay (IFMA) specific for aMMP-8 was used as the reference method. Results Fourteen saliva samples out of a total of 47 showed positivity for aMMP-8 PoC test. Both the TREM-1 and the aMMP-8 (IFMA) levels were significantly elevated among the aMMP-8 PoC test positives compared with the PoC test negatives (P = 4 mm was significantly lower among the adolescents that had a negative aMMP-8 PoC test result, and TREM-1 levels = 4 mm (P

Regional personality differences have been linked to regional entrepreneurship in Western countries. Here, we offer a first analysis of the relationship between regional personality and manifest and latent entrepreneurship in China. Because Western research has highlighted the role of an entrepreneurial constellation of the Big Five traits, we compare region-level correlates of Big Five scores with corresponding correlates of indigenous “Confucian” traits, interpersonal relatedness, and its sub-facets traditionalism, Renqing, face, discipline, and harmony. We utilize personality data collected from a representative sample (N = 26,405) of 44 major Chinese cities. We find substantial, meaningful, and robust negative correlations of interpersonal relatedness and its sub-facet traditionalism, face, and discipline with indicators of both manifest entrepreneurship (e.g., rate of newly registered individually owned businesses) and latent entrepreneurship (e.g., number of entrepreneurship-related search queries in the leading Chinese internet search engine: Baidu.com). Robustness checks using the geographical distance to the Forbidden City in Beijing as an exogenous instrument for regional “Confucian” traits supported our findings. In contrast, regional levels in the Big Five traits and in an entrepreneurial Big Five profile were rather irrelevant (e.g., openness was negatively associated with indicators of manifest entrepreneurship). Our study indicates the usefulness of an indigenous personality approach in the study of entrepreneurship in China. The present results give rise to the idea that in populations in China with less emphasis on traditional Confucian values and norms, the development of an active entrepreneurial culture is more accelerated.

BACKGROUND The right to adequate outpatient palliative care has existed for several years in Germany. In recent years outpatient palliative care has developed very positively. Nevertheless, in emergency situations paramedics and emergency physicians were often included in the care of palliative care of patients. The aim of our study was to investigate the cooperation between outpatient palliative care teams and the emergency medical services. Another aim was to identify structural realities and based on these to discuss the possibilities in the optimization of outpatient palliative medical emergency situations. METHODS A standardized self-designed questionnaire was distributed to specialized outpatient palliative care teams (SPCS) in Germany. For this purpose, closed and open questions (mixed methods) were used. The evaluation was carried out according to the questionnaire categories in quantitative and qualitative forms. The questionnaire was subdivided into general information and specific questions. RESULTS The survey response rate was 79% from a total of 81 SPCS in 2011. The following standards in palliative emergency care were recommended: (1) early integration of outpatient palliative care services and basic outpatient palliative care systems, (2) end-of-life discussions, (3) defined emergency medical documents, emergency drug boxes, do not attempt resuscitation orders and (4) emergency medical training (physicians and paramedics). CONCLUSION Outpatient palliative care in Germany has developed very positively during the last years; however, there are still deficits in terms of optimal patient care, one of which refers to the treatment of palliative care emergencies. In this context, optimization in the cooperation between outpatient palliative care services and emergency medical services should be discussed.

While the study of personality differences is a traditional psychological approach in entrepreneurship research, economic research directs attention towards the entrepreneurial ecosystems in which entrepreneurial activity are embedded. We combine both approaches and quantify the interplay between the individual personality make-up of entrepreneurs and the local personality composition of ecosystems, with a special focus on person-city personality fit. Specifically, we analyse personality data from N = 26,405 Chinese residents across 42 major Chinese cities, including N = 1091 Chinese entrepreneurs. Multi-level polynomial regression and response surface plots revealed that: (a) individual-level conscientiousness had a positive effect and individual-level agreeableness and neuroticism had a negative effect on entrepreneurial success, (b) city-level conscientiousness had a positive, and city-level neuroticism had a negative effect on entrepreneurial success, and (c) additional person-city personality fit effects existed for agreeableness, conscientiousness and neuroticism. For example, entrepreneurs who are high in agreeableness and conduct their business in a city with a low agreeableness level show the lowest entrepreneurial success. In contrast, entrepreneurs who are low in agreeableness and conduct their business in a city with a high agreeableness level show relatively high entrepreneurial success. Implications for research and practice are discussed.

Long-term continuous intra-arterial nimodipine infusion (CIAN) is a rescue therapy option in cases of severe refractory cerebral vasospasm (CV) following acute non-traumatic subarachnoid hemorrhage (SAH). However, CIAN therapy can be associated with relevant side effects. Available studies focus on intracerebral complications, whereas extracerebral side effects are rarely examined. Aim of the present study was to generate descriptive data on the clinical course during CIAN therapy and expectable extracerebral side effects. All patients treated with CIAN therapy for at least 5 days between May 2011 and December 2015 were included. We retrospectively extracted data from the patient data management system regarding the period between 2 days before the beginning and 5 days after the termination of CIAN therapy to analyze the course of ventilation parameters and pulmonary gas exchange, hemodynamic support, renal and liver function, integrity of the gastrointestinal tract, and the occurrence of infectious complications. In addition, we recorded the mean daily values of intracranial pressure (ICP) and intracerebral problems associated with CIAN therapy. Data from 28 patients meeting inclusion criteria were analyzed. The mean duration of long-term CIAN therapy was 10.5 ± 4.5 days. Seventeen patients (60.7%) reached a good outcome level (Glasgow Outcome Scale [GOS] 4–5) 6 months after SAH. An impairment of the pulmonary gas exchange occurred only at the very beginning of CIAN therapy. The required vasopressor support with norepinephrine was significantly higher on all days during and the first day after CIAN therapy compared to the situation before starting CIAN therapy. Two patients required short-time resuscitation due to cardiac arrest during CIAN therapy. Acute kidney injury was observed in four patients, and one of them required renal replacement therapy with sustained low-efficiency daily dialysis. During CIAN therapy, 23 patients (82.1%) needed the escalation of a previous antiinfective therapy or the onset of antibiotics which was in line with a significant increase of C-reactive protein and white blood cell count. Obstipation was observed in 22 patients (78.6%). Ten patients (35.7%) even showed insufficient defecation on at least seven consecutive days. Compared to the situation before, ICP was significantly higher during the whole period of CIAN therapy. Long-term CIAN therapy is associated with diverse side effects. The leading problems are an impairment of the hemodynamic situation and cardiac problems, an increase in infectious complications, a worsening of the motility of the gastrointestinal tract, and rising ICP values. Teams on neurointensive care units must be aware of these side effects to avoid that the beneficial effects of CIAN therapy on CV reported elsewhere are foiled by the problems this technique can be associated with.

We investigated whether the link between family-of-origin socioeconomic status (SES) and civic engagement in young adulthood is mediated by youth’s work values, i.e., the desired characteristics of their current or future jobs. We used data from a Finnish study: 2004 (age 16–18, NT1 = 1,301); 2011 (age 23–25, N T2 = 1,096); and 2014 (age 25–27, NT3 = 1,138). A lower family SES in 2004 was negatively related to youth’s civic engagement in 2014. Lower family SES predicted the importance that youth attached to extrinsic job rewards (e.g., good pay) in 2011, but not the importance of intrinsic job rewards (e.g., learning opportunities). Extrinsic work values, in turn, predicted lower civic engagement in 2014, above and beyond sociodemographic and personality characteristics. Conversely, intrinsic work values predicted higher civic engagement. Thus, extrinsic, but not intrinsic, work values partly mediated the link between SES and youth civic engagement. peerReviewed

Periodontal disease entails the inflammatory destruction of the tooth supporting (periodontal) tissues as a result of polymicrobial colonization of the tooth surface in the form of biofilms. Extensive data collected over the past decades on this chronic disease demonstrate that its progression is infrequent and episodic, and the susceptibility to it can vary among individuals. Physical assessments of previously occurring damage to periodontal tissues remain the cornerstone of detection and diagnosis, whereas traditionally used diagnostic procedures do neither identify susceptible individuals nor distinguish between disease-active and disease-inactive periodontal sites. Thus, more sensitive and accurate "measurable biological indicators" of periodontal diseases are needed in order to place diagnosis (e.g., the presence or stage) and management of the disease on a more rational less empirical basis. Contemporary "omics" technologies may help unlock the path to this quest. High throughput nucleic acid sequencing technologies have enabled us to examine the taxonomic distribution of microbial communities in oral health and disease, whereas proteomic technologies allowed us to decipher the molecular state of the host in disease, as well as the interactive cross-talk of the host with the microbiome. The newly established field of metaproteomics has enabled the identification of the repertoire of proteins that oral microorganisms use to compete or co-operate with each other. Vast such data is derived from oral biological fluids, including gingival crevicular fluid and saliva, which is progressively completed and catalogued as the analytical technologies and bioinformatics tools progressively advance. This chapter covers the current "omics"-derived knowledge on the microbiome, the host and their "interactome" with regard to periodontal diseases, and addresses challenges and opportunities ahead.

Objective Salivary total protease and chitinase activities were measured by a broad-spectrum fluorescence resonance energy transfer approach as predictors of induction and resolution of gingival inflammation in healthy individuals by applying an experimental human gingivitis model.Methods Dental biofilm accumulated (21 days, Induction Phase) by omitting oral hygiene practices followed by a 2-week Resolution Phase to restore gingival health in an experimental gingivitis study. Plaque accumulation, as assessed by the Turesky Modification of the Quigley-Hein Plaque Index (TQHPI), and gingival inflammation, assessed using the Modified Gingival Index (MGI), scores were recorded and unstimulated saliva was collected weekly. Saliva was analysed for total protein, albumin, total protease activity and chitinase activity (n = 18)Results The TQHPI and MGI scores, as well as total protease activity, increased until day 21. After re-establishment of oral hygiene, gingival inflammation levels returned to values similar to baseline (day 0). Levels of protease activity decreased significantly, but not to baseline values. Furthermore, ‘fast’ responders, who responded immediately to plaque, exhibited significantly higher proteolytic activity throughout the experimental course than ‘slow’ responders, who showed a lagged inflammatory response.Conclusion The results indicate that differential inflammatory responses encompass inherent variations in total salivary proteolytic activities, which could be further utilised in contemporary diagnostic, prognostic and treatment modalities for periodontal diseases.

Introduction: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathway is stimulated by bacteria and, together with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), propagates proinflammatory responses. Objectives: We aimed to evaluate the TREM-1/PGLYRP1/interleukin (IL)–1β regulation in response to biofilm accumulation and removal in an experimental human gingivitis model. Methods: The study (n = 42 participants, mean age: 23.8 ± 3.7 y) comprised a recruitment step (day –14) followed by experimentally induced biofilm formation (induction [I] phase, day 0 to +21) and a 2-wk resolution (R) phase (day +21 to +35). Plaque was recorded by the Modified Quigley and Hein Plaque Index (TQHPI), while records of gingival inflammation were based on the Modified Gingival Index (MGI). Unstimulated whole saliva supernatants (n = 210, 5 time points) were tested for TREM-1, PGLYRP1, and IL-1β by enzyme-linked immunosorbent assay. Results: During the I-phase, concentrations of all analytes showed a tendency for downregulation at day +7 compared to day 0. TREM-1 (P = 0.019) and PGLYRP1 (P = 0.007) increased significantly between day +7 and day +21. Although all analyte levels decreased during the R-phase, the difference was not significant except TREM-1 being at borderline significance (P = 0.058). Moreover, TREM-1, PGLYRP1, and IL-1β showed significant positive correlations (P < 0.0001) with each other. The study participants were grouped into “fast” and “slow” responders based on clinical gingival inflammation scores. At each time point, fast responders showed significantly higher concentrations of TREM-1 (P < 0.025), PGLYRP1 (P < 0.007), and IL-1β (P < 0.025) compared to slow responders. Mixed-effects multilevel regression analyses revealed that PGLYRP1 (P = 0.047) and IL-1β (P = 0.005) showed a significant positive association with the MGI scores. Conclusion: The study demonstrated that TREM-1 and PGLYRP1 are regulated in response to biofilm accumulation and removal, and fast responders demonstrated higher levels of these analytes compared to slow responders. Knowledge Transfer Statement: The results of this study demonstrated the suitability of salivary TREM-1 and PGLYRP1 to reflect biofilm accumulation and removal and PGLYRP1 to monitor the progression and resolution of inflammation in gingivitis-susceptible individuals (fast responders). Combined with conventional risk factors, the molecular toolbox proposed here should be further validated in future studies to confirm whether it can be used for population-based monitoring and prevention of gingivitis.

Periodontal disease entails the inflammatory destruction of the tooth supporting (periodontal) tissues as a result of polymicrobial colonization of the tooth surface in the form of biofilms. Extensive data collected over the past decades on this chronic disease demonstrate that its progression is infrequent and episodic, and the susceptibility to it can vary among individuals. Physical assessments of previously occurring damage to periodontal tissues remain the cornerstone of detection and diagnosis, whereas traditionally used diagnostic procedures do neither identify susceptible individuals nor distinguish between disease-active and disease-inactive periodontal sites. Thus, more sensitive and accurate "measurable biological indicators" of periodontal diseases are needed in order to place diagnosis (e.g., the presence or stage) and management of the disease on a more rational less empirical basis. Contemporary "omics" technologies may help unlock the path to this quest. High throughput nucleic acid sequencing technologies have enabled us to examine the taxonomic distribution of microbial communities in oral health and disease, whereas proteomic technologies allowed us to decipher the molecular state of the host in disease, as well as the interactive cross-talk of the host with the microbiome. The newly established field of metaproteomics has enabled the identification of the repertoire of proteins that oral microorganisms use to compete or co-operate with each other. Vast such data is derived from oral biological fluids, including gingival crevicular fluid and saliva, which is progressively completed and catalogued as the analytical technologies and bioinformatics tools progressively advance. This chapter covers the current "omics"-derived knowledge on the microbiome, the host and their "interactome" with regard to periodontal diseases, and addresses challenges and opportunities ahead.

Supplemental material, DS_10.1177_2380084419844937 for Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation by A. Silbereisen, A.K. Hallak, G.G. Nascimento, T. Sorsa, G.N. Belibasakis, R. Lopez and N. Bostanci in JDR Clinical & Translational Research

Adolescent risk taking is strongly influenced by peer presence. The aim of the present study was to investigate the effect of peer presence on the ERP after negative and positive feedback in the time range of the feedback-related negativity (FRN). Eighteen male adolescents completed a version of the Balloon Analogue Risk Task (BART) under two conditions: playing alone and while observed by a peer. We recorded the ERPs after success or failure feedback and analyzed risk-taking behavior under both conditions. Behavioral results show that the participants were more cautious when being watched by a peer, especially after success. ERPs show that participants under peer presence exhibit more negative FRN after failure feedback than in the single condition, but no greater positivities after success feedback in the observed condition compared to the single condition. Results are in line with reinforcement learning theory and psychological aspects of loss prevention. The results suggest that the effect of peer presence on risk-taking behavior depends on the specific situational context.

Longitudinal data collected between 2005 and 2009 is analyzed to investigate the interplay of trajectories of perceived demands in the domains of work and family. Quadratic latent growth curve models were used to mimic the increase of demands in N = 1,296 young adults from Germany as structural uncertainty increased in the second half of the study. Demands in the different domains develop highly parallel, reflecting possible spill-over effects between the domains, and seem to indicate changes of objective uncertainty during the outset of the global financial crisis. Furthermore, there is also evidence for cumulative disadvantage and inoculation effects.

Recent changes in labor market and working conditions have rendered youth's education-to-work transitions and career prospects more uncertain. This study investigated how youth, while still in education or training, deal with perceived growing occupational uncertainties in terms of goal engagement (i.e., investing active effort in goal pursuit; surmounting obstacles) and goal disengagement (i.e., distancing from unattainable goals; protecting the self against failure experiences). Analyses with two closely matched samples of youth aged 16–25 years from Germany ( N = 529) and Poland ( N = 530) revealed high levels of goal engagement and a clear preference of engagement over disengagement. Whereas levels of engagement were comparable across countries, disengagement was considerably higher in Polish youth. Regarding the sources of individual differences in engagement and disengagement, sociodemographic factors had very limited effects in both countries. Compared to sociodemographic factors, the level of perceived growing occupational uncertainties, and especially youth's primary and secondary appraisals thereof, were more strongly and consistently associated with engagement and disengagement, especially in Germany, pointing to the prominence of perceptions and appraisals in shaping youth's responses to growing occupational uncertainties. We offer cultural and economic explanations for these findings and discuss implications for interventions aimed at fostering youth's engagement in preparing for their future careers under today's uncertain conditions.