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This study provides normative data useful for interpreting scores from the Pocket Smell Test® (PST®), a brief “scratch & sniff” neuropsychological olfactory screening test comprised of 8 items from the 40-item University of Pennsylvania Smell Identification Test (UPSIT®). We combined 3,485 PST® scores from the 2013 to 2014 National Health and Nutrition Survey (NHANES) of persons 40 years of age and older with equivalent PST® items extracted from an UPSIT® database of 3,900 persons ranging in age from 5 to 99 years. Decade-related age- and gender-adjusted percentile normative data were established across the entire age spectrum. Cut-points for defining clinically useful categories of anosmia, probable microsmia, and normosmia were determined using receiver operating characteristic (ROC) curve analyses. An age-related decline in test scores was evident for both sexes after the age of 40 years, with women outperforming men. Based on the ROC analyses, subjects scoring 3 or less (AUC = 0.81) defines anosmia. Regardless of sex, a score of 7 or 8 on the N-PST® signifies normal function (AUC of 0.71). Probable microsmia is classified as scores extending from 3 to 6. These data provide an accurate means for interpreting PST® scores within a number of clinical and applied settings.

\item[Background] The nuclear responses for antineutrinos associated with double beta decays (DBDs) and astro-antineutrino interactions are studied by measuring ordinary muon capture (OMC) rates. \item[Purpose]The experimental studies of absolute OMC rates and their mass number dependence for $^{100}$Mo and the natural Mo are currently of interest in astro-antineutrinos and DBDs. \item[Method]The OMC rates were obtained experimentally by measuring the time spectrum of the trapped muon's decay into electrons to obtain the half-lives of the trapped muons. \item[Results]The OMC rate for the enriched isotope of $^{100}$Mo is $\Lambda$($^{100}$Mo)=(7.07$\pm$0.32)$\times10^{6}$ s$^{-1}$, while that for the natural Mo is $\Lambda$($^{\rm nat}$Mo)=(9.66$\pm$0.44)$\times10^{6}$ s$^{-1}$, i.e., $\Lambda$($^{100}$Mo) is about 27$\%$ of $\Lambda$($^{\rm nat}$Mo), reflecting the blocking effect of the excess neutrons for the proton-to-neutron transformation in OMC. The present experimental observation is consistent with the predictions using Goulard-Primakoff's (GPs) and Primakoff's (Ps) empirical equations. \item[Conclusions] The absolute OMC rates for $^{100}$Mo and $^{\rm nat}$Mo were measured. The large neutron excess in $^{100}$Mo gives a much lower OMC rate than $^{\rm nat}$Mo. On both $^{100}$Mo and $^{\rm nat}$Mo, consistent OMC rates with the GP and P values are observed., Comment: 5 pages, 3 figures, 2 tables

A neutron-energy dependent angular distribution was measured for individual $\gamma$-rays from the 3.2 eV $p$-wave resonance of $^{131}$Xe+$n$, that shows enhanced parity violation owing to a mixing between $s$- and $p$-wave amplitudes. The $\gamma$-ray transitions from the $p$-wave resonance were identified, and the angular distribution with respect to the neutron momentum was evaluated as a function of the neutron energy for 7132 keV $\gamma$-rays, which correspond to a transition to the 1807 keV excited state of $^{132}$Xe. The angular distribution is considered to originate from the interference between $s$- and $p$-wave amplitudes, and will provide a basis for a quantitative understanding of the enhancement mechanism of the fundamental parity violation in compound nuclei.

Largely enhanced parity-violating effects observed in compound resonances induced by epithermal neutrons are currently attributed to the mixing of parity-unfavored partial amplitudes in the entrance channel of the compound states. Furthermore, it is proposed that the same mechanism that enhances the parity-violation also enhances the breaking of time-reversal-invariance in the compound nucleus. The entrance-channel mixing induces energy-dependent spin-angular correlations of individual $\gamma$-rays emitted from the compound nuclear state. For a detailed study of the mixing model, a $\gamma$-ray yield in the reaction of $^{117}$Sn(n,$\gamma$)$^{118}$Sn was measured using the pulsed beam of polarized epithermal neutrons and Ge detectors. An angular dependence of asymmetric $\gamma$-ray yields for the orientation of the neutron polarization was observed., Comment: 7 pages, 10 figures

ObjectiveLiver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies.DesignIndividual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations.ResultsData were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (ConclusionSequential combinations of markers with a lower cut-off to rule-out advanced fibrosis and a higher cut-off to rule-in cirrhosis can reduce the need for liver biopsies.

Background:Coronavirus Disease (COVID-19) vaccines have been licensed for usage and have been delivered over the globe in various regions. There is a lack of public awareness and understanding of COVID-19 vaccinations, however. As a result, researchers conducted a survey to see what Bangladeshis had to say about COVID-19 vaccinations. Methods:This cross-sectional study, conducted among the general population of Bangladesh, asked a series of questions about the KAP of the population with regard to COVID-19 vaccination, and the demographic characteristics of participants and the source of information with regard to the COVID-19 vaccine were recorded and analyzed. Results:A total of 386 complete surveys were included in the final analysis. 35.2% of people, who took part in it, said that everyone in Bangladesh should get the COVID-19 vaccine, while 64.8% said no to this idea. As a result of our survey, 73.6% of respondents believed that the new COVID-19 vaccination, which is now used in Bangladesh, may cause negative effects. Although a large number of the population was illiterate (44.6%), our study indicated that those with higher levels of education had a better understanding of the COVID-19 vaccination. This research indicated that those who had previously received a vaccination had a better understanding of the COVID-19 vaccine. For this to be successful, people must have had positive vaccination experiences in the past. There is a far greater awareness about COVID-19 vaccinations in urban areas compared to rural places. However, when multiple regressions were used, this association did not hold up. Conclusion:In Bangladesh, many are unfamiliar with the COVID-19 vaccination, but they have a positive attitude toward it. Before mass vaccines are planned in the near future, health education campaigns must begin immediately to assist people in better understanding their health.

Background:In a public health crisis, knowledge and understanding of disease transmission modes, fundamental hygiene concepts, and procedures are critical for designing effective control measures. The purpose of this research was to assess the Bangladeshi population's Knowledge, Attitude and Practice (KAP) towards COVID-19. Methods:A series of questions about the KAP of the population about COVID-19 were asked in this cross-sectional study, which was conducted among the general population of Bangladesh over the age of 15, and participants' demographic characteristics and source of information about COVID-19 were recorded and analyzed. Results:Despite the fact that the majority of respondents (more than 60%) had a positive attitude about COVID-19, 70% of those questioned in Bangladesh had insufficient understanding and preventative actions. This latter discovery is promising and suggests a potential therapeutic strategy. Male and less educated respondents reported inadequate COVID-19 preventive methods, as well as a lack of understanding about signs and symptoms and transmission. The findings revealed a substantial link between knowledge, attitude, and practice among women of a certain gender, age, and education level. Male gender, non-healthcare-related jobs, single status, and a lesser degree of schooling were all substantially correlated with poorer knowledge scores, according to multiple linear regression analysis. Conclusion:The present study revealed a high attitude among the study population towards COVID-19 but a poor response on knowledge and preventive practices, which can be enhanced by awareness campaigns and proper planning.

JSNS $$^2$$ 2 (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) is an experiment that is searching for sterile neutrinos via the observation of $${\bar{\nu }}_{\mu } \rightarrow {\bar{\nu }}_{e}$$ ν ¯ μ → ν ¯ e appearance oscillations using muon decay-at-rest neutrinos. Before dedicated data taking in the first-half of 2021, we performed a commissioning run for 10 days in June 2020. Using the data obtained in this commissioning run, in this paper, we present an estimate of the correlated background which imitates the $${\bar{\nu }}_{e}$$ ν ¯ e signal in a sterile neutrino search. In addition, in order to demonstrate future prospects of the JSNS $$^2$$ 2 experiment, possible pulse shape discrimination improvements towards reducing cosmic ray induced fast neutron background are described.

JSNS$^2$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) is an experiment that is searching for sterile neutrinos via the observation of $\bar{\nu}_{\mu} \to \bar{\nu}_{e}$ appearance oscillations using muon decay-at-rest neutrinos. Before dedicated data taking in the first-half of 2021, we performed a commissioning run for 10 days in June 2020. Using the data obtained in this commissioning run, in this paper, we present an estimate of the correlated background which imitates the $\bar{\nu}_{e}$ signal in a sterile neutrino search. In addition, in order to demonstrate future prospects of the JSNS$^2$ experiment, possible pulse shape discrimination improvements towards reducing cosmic ray induced fast neutron background are described., Comment: 7 pages, 3 figures

The neutron energy-dependent angular distribution of $\gamma$ rays from $^{117}{\rm Sn}(n,\gamma)$ reaction was measured with germanium detectors and a pulsed neutron beam. The angular distribution was clearly observed in $\gamma$-ray emissions with an energy of 9327 keV which corresponds to the transition from a neutron resonance of $^{117}{\rm Sn}+n$ to the ground state of $^{118}{\rm Sn}$. The angular distribution causes an angular-dependent asymmetric resonance shape. An asymmetry $A_{\rm LH}$ was defined as $(N_{\rm L}-N_{\rm H})/(N_{\rm L}+N_{\rm H})$, where $N_{\rm L}$ and $N_{\rm H}$ are integrated values for lower- and higher-energy regions of a neutron resonance, respectively. We found that the $A_{\rm LH}$ has the angular dependence of $(A \cos \theta_\gamma +B)$, where $\theta_\gamma$ is the $\gamma$-ray emission angle with respect to the incident neutron momentum, with $A=0.394 \pm 0.073$ and $B = 0.118 \pm 0.029$ in the 1.33 eV p-wave resonance., Comment: 5 pages, 5 figures

Largely enhanced parity-violating effects observed in compound resonances induced by epithermal neutrons are currently attributed to the mixing of parity-unfavored partial amplitudes in the entrance channel of the compound states. Furthermore, it is proposed that the same mechanism that enhances the parity-violation also enhances the breaking of time-reversal-invariance in the compound nucleus. The entrance-channel mixing induces energy-dependent spin-angular correlations of individual $γ$-rays emitted from the compound nuclear state. For a detailed study of the mixing model, a $γ$-ray yield in the reaction of $^{117}$Sn(n,$γ$)$^{118}$Sn was measured using the pulsed beam of polarized epithermal neutrons and Ge detectors. An angular dependence of asymmetric $γ$-ray yields for the orientation of the neutron polarization was observed., 7 pages, 10 figures

The neutron energy-dependent angular distribution of $γ$ rays from $^{117}{\rm Sn}(n,γ)$ reaction was measured with germanium detectors and a pulsed neutron beam. The angular distribution was clearly observed in $γ$-ray emissions with an energy of 9327 keV which corresponds to the transition from a neutron resonance of $^{117}{\rm Sn}+n$ to the ground state of $^{118}{\rm Sn}$. The angular distribution causes an angular-dependent asymmetric resonance shape. An asymmetry $A_{\rm LH}$ was defined as $(N_{\rm L}-N_{\rm H})/(N_{\rm L}+N_{\rm H})$, where $N_{\rm L}$ and $N_{\rm H}$ are integrated values for lower- and higher-energy regions of a neutron resonance, respectively. We found that the $A_{\rm LH}$ has the angular dependence of $(A \cos θ_γ+B)$, where $θ_γ$ is the $γ$-ray emission angle with respect to the incident neutron momentum, with $A=0.394 \pm 0.073$ and $B = 0.118 \pm 0.029$ in the 1.33 eV p-wave resonance., 5 pages, 5 figures

A neutron-energy dependent angular distribution was measured for individual $γ$-rays from the 3.2 eV $p$-wave resonance of $^{131}$Xe+$n$, that shows enhanced parity violation owing to a mixing between $s$- and $p$-wave amplitudes. The $γ$-ray transitions from the $p$-wave resonance were identified, and the angular distribution with respect to the neutron momentum was evaluated as a function of the neutron energy for 7132 keV $γ$-rays, which correspond to a transition to the 1807 keV excited state of $^{132}$Xe. The angular distribution is considered to originate from the interference between $s$- and $p$-wave amplitudes, and will provide a basis for a quantitative understanding of the enhancement mechanism of the fundamental parity violation in compound nuclei.

Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

ImportanceSudden smell loss is a specific early symptom of COVID-19, with an estimated prevalence of ~40% to 75%. Smell impairment affects physical and mental health, and dietary behavior. Thus, it is critical to understand the rate and time course of smell recovery.ObjectiveTo characterize smell function and recovery up to 11 months post COVID-19 infection.Settings, ParticipantsThis longitudinal survey of individuals suffering COVID-19-related smell loss assessed disease symptoms and gustatory and olfactory function. Participants (n=12,313) who completed an initial respiratory symptoms, chemosensory function and COVID-19 diagnosis survey (S1) between April and September 2020 and completed a follow-up survey (S2) between September 2020 and February 2021; 27.5% participants responded (n=3,386), with 1,468 being diagnosed with COVID-19 and suffering co-occurring smell and taste loss at the beginning of their illness.Main Outcomes & MeasuresPrimary outcomes are ratings of smell and taste function on a visual analog scale, and self-report of parosmia (smell distortions) and phantosmia (unexplained smells). Secondary outcomes include a checklist of other COVID-19 symptoms.ResultsOn follow-up (median time since COVID-19 onset ~200 days), ~60% of women and ~48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered. Prevalence of parosmia and phantosmia was ~10% of participants in S1 and increased substantially in S2: ~47% for parosmia and ~25% for phantosmia. Persistent smell impairment was associated with more symptoms overall, suggesting it may be a key marker of long-COVID. During COVID-19 illness, the ability to smell was slightly lower among those who did not recover their pre-illness ability to smell at S2.Conclusions and RelevanceWhile smell loss improves for many individuals who lost it due to COVID-19, the prevalence of parosmia and phantosmia increases substantially over time. Olfactory dysfunction is also associated with wider COVID-19 symptoms and may persist for many months after COVID-19 onset. Taste loss in the absence of smell loss is rare. Persistent qualitative smell symptoms are emerging as common long term sequelae; more research into treatment options is strongly warranted given that conservative estimates suggest millions of individuals may experience parosmia following COVID-19. Healthcare providers worldwide need to be prepared to treat post COVID-19 secondary effects on physical and mental health.Trial registrationThis project was pre-registered at OSF: https://osf.io/3e6zc.Graphical abstractKey PointsQuestionWhat are the characteristics of smell and taste recovery of COVID-19 patients?FindingsIn this preregistered observational study of 1,468 participants, smell loss is associated with a higher number of COVID-19 symptoms, and may persist for at least 11 months following disease onset. While a majority of participants report quantitative improvement in their ability to smell, the prevalence of parosmia and phantosmia increases substantially at follow-up. Taste recovers faster than smell, suggesting taste and smell recover separately and can be distinguished by the respondents.MeaningOlfactory dysfunction appears to be a component of long-COVID, with parosmia as a prominent symptom in almost half of those with smell loss. More research into treatment is needed, especially given that olfactory dysfunction is associated with depression and loss of appetite. Health professionals should be aware of these common and long lasting effects.

We measured the total capture cross section of the O16(n,γ)O17 reaction, as well as partial cross sections leading to the ground (Jπ=5/2+) and first-excited (Jπ=1/2+) states in O17. The measurement was carried out at average neutron energies of 157, 349, 398, 427, 468, 498, and 556 keV by using pulsed neutrons produced via the Li7(p,n)Be7 reaction and a γ-ray detection system based on an anti-Compton NaI(Tl) spectrometer. We observed the interference effect between the 3/2- resonance state at 4554 keV of O17, corresponding to a neutron energy of 411 keV in the center-of-mass system, and a nonresonant contribution in the capture process. The measured partial cross sections are in good agreement with theoretical calculations obtained taking into account the interference between the 3/2- resonance and a nonresonant p-wave direct radiative capture contribution. Using the present results, together with our previous measurement, we derived the Maxwellian-averaged capture cross sections (MACS) for thermal energies between kT=5 and 100 keV, key quantities for s process nucleosynthesis studies in massive stars.

An objective approach for odor detection is to analyze the brain activity using imaging techniques during the odor stimulation. In this study, Functional Near Infrared Spectroscopy (fNIRS) is used to record hemodynamic response from the frontal region of the brain by using a 4-channel fNIRS system. The fNIRs data is collected during the odor detection task in which the subjects were asked to press a button when they detect the given odor. Functional Data Analysis (FDA) was applied on fNIRs data to convert discrete measured samples of data to continuous smooth curves. The FDA method enables us to use the bases coefficients of fNIRS smoothed curves for features that represent the shape of the raw fNIRS signal. With the learning algorithm that we proposed, these features were used to train the support vector machine classifier. We evaluated the odor detection problem, in two binary classification cases: odorant vs. non-odorant and odorant vs. fingertapping. The model achieved a classification accuracy of 94.12% and 97.06% over the stimulus condition in the two cases, respectively. Moreover to find the actual predictors we used the extracted defined features (slope, standard deviation, and delta) to train our classifier. We achieved an average accuracy of 91.18 % on classifying odorant vs. non-odorant and an accuracy of 94.12% for odorant vs. fingertapping on the stimulus condition. The results determined that fNIRs signals of odorant and non-odorant are distinguishable without being affected by the motor activity during the experiment.These findings suggest that fNIRs measurement on the forehead could be potentially used for objective and comparably inexpensive assessment of odor detection in cases that the subjective report is unreliable.

A dark matter search project needs and extremely low background radiation detector since the expected event rate of dark matter is less than a few events in one year in one tonne of the detector mass. The authors developed a highly radiopure NaI(Tl) crystal to search for dark matter. The best combination of the purification methods was developed, resulting $^{\mathrm{nat}}$K and $^{210}$Pb were less than 20 ppb and 5.7 $\mu$Bq/kg, respectively. The authors will construct a large volume detector system with high-purity NaI(Tl) crystals. The design and the performance of the prototype detector module will be reported in this article., Comment: 12 pages, 7 figures, RADIATION DETECTORS AND THEIR USES Proceedings of the 35th Workshop on Radiation Detectors and Their Uses in KEK

Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies. Design Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations. Results Data were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (

Neutron energy-dependent angular distributions were observed for individual $\gamma$-rays from the 0.74 eV p-wave resonance of $^{139}$La+$n$ to several lower excited states of $^{140}$La. The $\gamma$-ray signals were analyzed in a two dimensional histogram of the $\gamma$-ray energy, measured with distributed germanium detectors, and neutron energy, determined with the time-of-flight of pulsed neutrons, to identify the neutron energy dependence of the angular distribution for each individual $\gamma$-rays. The angular distribution was also found for a photopeak accompanied with a faint p-wave resonance component in the neutron energy spectrum. Our results can be interpreted as interference between s- and p-wave amplitudes which may be used to study discrete symmetries of fundamental interactions., Comment: 6 pages, 7 figures

Neutron energy-dependent angular distributions were observed for individual $��$-rays from the 0.74 eV p-wave resonance of $^{139}$La+$n$ to several lower excited states of $^{140}$La. The $��$-ray signals were analyzed in a two dimensional histogram of the $��$-ray energy, measured with distributed germanium detectors, and neutron energy, determined with the time-of-flight of pulsed neutrons, to identify the neutron energy dependence of the angular distribution for each individual $��$-rays. The angular distribution was also found for a photopeak accompanied with a faint p-wave resonance component in the neutron energy spectrum. Our results can be interpreted as interference between s- and p-wave amplitudes which may be used to study discrete symmetries of fundamental interactions., 6 pages, 7 figures

This is a correction notice for article bjaa041 (DOI: https:// doi.org/10.1093/chemse/bjaa041), published 20 June 2020. An incorrect version of the caption to Figure 5 was mistakenly included in the published paper. An updated version is given below. Neither the data nor the paper's conclusions were affected by this correction. The authors sincerely apologize for the error. (A) Correlations between the 3 principal components with respect to changes in 3 chemosensory modalities (i.e., taste, smell, and chemesthesis). Shades of gray indicate positive correlation, whereas shades of red indicate negative correlations. White denotes no correlation. (B) Clusters of participants identified by k-means clustering. The scatterplot shows each participant's loading on dimension 1 (degree of smell and taste loss, PC1 on x-Axis) and dimension 2 (degree of chemesthesis loss, PC2 on y-Axis). Based on the centroid of each cluster, participants in cluster 1 (blue, N = 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Participants in cluster 2 (orange, N = 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Loadings for participants in cluster 3 (green, N = 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis.

PICOLON (Pure Inorganic Crystal Observatory for LOw-energy Neutr(al)ino) aims to search for cosmic dark matter by high purity NaI(Tl) scintillator. We developed extremely pure NaI(Tl) crystal by hybrid purification method. The recent result of $^{210}$Pb in our NaI(Tl) is less than 5.7 $\mu$Bq/kg. We will report the test experiment in the low-background measurement at Kamioka Underground Laboratory. The sensitivity for annual modulating signals and finding dark matter particles will be discussed., Comment: To be published in the Proceedings of TAUP2021. (Journal of Physics: Conference Series (JPCS),)

BACKGROUND: Considerable evidence suggests that smell dysfunction is common in coronavirus disease-2019 (COVID-19). Unfortunately, extant data on prevalence and reversibility over time are highly variable, coming mainly from self-report surveys prone to multiple biases. Thus, validated psychophysical olfactory testing is sorely needed to establish such parameters. METHODS: One hundred severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-positive patients were administered the 40-item University of Pennsylvania Smell Identification Test (UPSIT) in the hospital near the end of the acute phase of the disease. Eighty-two were retested 1 or 4 weeks later at home. The data were analyzed using analysis of variance and mixed-effect regression models. RESULTS: Initial UPSIT scores were indicative of severe microsmia, with 96% exhibiting measurable dysfunction; 18% were anosmic. The scores improved upon retest (initial test: mean, 21.97; 95% confidence interval [CI], 20.84-23.09; retest: mean, 31.13; 95% CI, 30.16-32.10; p < 0.0001); no patient remained anosmic. After 5 weeks from COVID-19 symptom onset, the test scores of 63% of the retested patients were normal. However, the mean UPSIT score at that time continued to remain below that of age- and sex-matched healthy controls (p < 0.001). Such scores were related to time since symptom onset, sex, and age. CONCLUSION: Smell loss was extremely common in the acute phase of a cohort of 100 COVID-19 patients when objectively measured. About one third of cases continued to exhibit dysfunction 6 to 8 weeks after symptom onset. These findings have direct implications for the use of olfactory testing in identifying SARS-CoV-2 carriers and for counseling such individuals with regard to their smell dysfunction and its reversibility.

BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort of COVID-19 patients has been performed. METHODS: The University of Pennsylvania Smell Identification Test (UPSIT), a well-validated 40-odorant test, was administered to 60 confirmed COVID-19 inpatients and 60 age- and sex-matched controls to assess the magnitude and frequency of their olfactory dysfunction. A mixed effects analysis of variance determined whether meaningful differences in test scores existed between the 2 groups and if the test scores were differentially influenced by sex. RESULTS: Fifty-nine (98%) of the 60 patients exhibited some smell dysfunction (mean [95% CI] UPSIT score: 20.98 [19.47, 22.48]; controls: 34.10 [33.31, 34.88]; p < 0.0001). Thirty-five of the 60 patients (58%) were either anosmic (15/60; 25%) or severely microsmic (20/60; 33%); 16 exhibited moderate microsmia (16/60; 27%), 8 mild microsmia (8/60; 13%), and 1 normosmia (1/60; 2%). Deficits were evident for all 40 UPSIT odorants. No meaningful relationships between the test scores and sex, disease severity, or comorbidities were found. CONCLUSION: Quantitative smell testing demonstrates that decreased smell function, but not always anosmia, is a major marker for SARS-CoV-2 infection and suggests the possibility that smell testing may help, in some cases, to identify COVID-19 patients in need of early treatment or quarantine.

Objective assessment of olfactory function has diagnostic and legal value. We have designed an odor detection task in which the subject reported the conscious sensing of an odorant via a button press while the hemodynamic activity from the forehead was monitored using a 4-channel fNIRS system. The task consisted of intermingled odor and non-odor trials. We recorded from 17 subjects and each of them underwent 60 trials. The time domain analysis of the raw data showed that the hemodynamic activity was statistically different between the odor and non-odor trials especially for oxyhemoglobin in far channels. In order to single out the odor-induced hemodynamic response from that of motor activity, finger tapping was considered as a control condition for odor detection. Pairwise correlation indicated that motor activity had a short lasting influence on hemodynamic response while the hemodynamic response to different odors were highly correlated over time. In conclusion, we believe that fNIRS monitoring of hemodynamic response could be potentially used for objective assessment of odor detection in cases that subjective report is unreliable.

A correlation term ${{ \sigma}_{n} }\cdot ({ k_{n}\times k_\gamma}) $ in the ${}^{139}{\rm La}(\vec{n},\gamma)$ reaction has been studied utilizing epithermal polarized neutrons and germanium detectors. The transverse asymmetry for single $\gamma$-ray transition was measured to be $0.60\pm0.19$ in the $p$-wave resonance.

The JSNS$^{2}$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) experiment aims to search for neutrino oscillations over a 24 m short baseline at J-PARC. The JSNS$^{2}$ inner detector is filled with 17 tons of gadolinium(Gd)-loaded liquid scintillator (LS) with an additional 31 tons of unloaded LS in the intermediate $\gamma$-catcher and an optically separated outer veto volumes. A total of 120 10-inch photomultiplier tubes observe the scintillating optical photons and each analog waveform is stored with the flash analog-to-digital converters. We present details of the data acquisition, processing, and data quality monitoring system. We also present two different trigger logics which are developed for the beam and self-trigger., Comment: 11 pages, 8 figures

This article describes the goal and expected sensitivity of the JSNS$^2$-II experiment at J-PARC Materials and Life Science Experimental Facility (MLF). The JSNS$^2$-II experiment is the second phase of the JSNS$^2$ experiment (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) with two detectors which are located in 24 m (an existing detector) and 48 m (new one) baselines to improve the sensitivity of the search for sterile neutrinos, especially in the low $\Delta m^2$ region, which has been indicated by the global fit of the appearance mode. The new second detector has a similar structure as the existing JSNS$^2$ detector, which is already working. To compensate for the reduction of the neutrino flux due to the distance from the mercury target, the target mass of the Gd-loaded liquid scintillator which is the Linear AlkylBenzene (LAB) based liquid scintillator inside the acrylic vessel is 35 tons. To keep the same photo-coverage of the detector as the first detector, we will surround the acrylic vessel with 240 PMTs. With this experimental setup and 5 years (times 1 MW beam power) exposure, the sensitivity of the JSNS$^2$-II is significantly improved compared to the current JSNS$^2$, especially in the low $\Delta m^2$ oscillation parameter region. The JSNS$^2$-II can also confirm or refute the most of the oscillation parameters' space preferred by the previous experiments with 3 sigma C.L.. Considering these situations and world wide status of the sterile neutrino searches, we are eager to start the data taking with the two detector configuration from 2023. The fund to build the second detector was already secured.

In this study, we evaluate and compare the pulse shape discrimination (PSD) performance of multipixel photon counters (MPPCs, also known as silicon photomultiphers - SiPMs) with that of a typical photomultiplier tube (PMT) when testing using CsI(Tl) scintillators. We use the charge comparison method, whereby we discriminate different types of particles by the ratio of charges integrated within two time-gates (the delayed part and the entire digitized waveform). For a satisfactory PSD performance, a setup should generate many photoelectrons (p.e.) and collect their charges efficiently. The PMT setup generates more p.e. than the MPPC setup does. With the same digitizer and the same long time-gate (the entire digitized waveform), the PMT setup is also better in charge collection. Therefore, the PMT setup demonstrates better PSD performance. We subsequently test the MPPC setup using a new data acquisition (DAQ) system. Using this new DAQ, the long time-gate is extended by nearly four times the length when using the previous digitizer. With this longer time-gate, we collect more p.e. at the tail part of the pulse and almost all the charges of the total collected p.e. Thus, the PSD performance of the MPPC setup is improved significantly. This study also provides an estimation of the short time-gate (the delayed part of the digitized waveform) that can give a satisfactory PSD performance without an extensive analysis to optimize this gate.

COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19. This preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing no significant model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ~50% of participants and was best predicted by time since illness onset. As smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (10

A correlation term ${{ ��}_{n} }\cdot ({ k_{n}\times k_��}) $ in the ${}^{139}{\rm La}(\vec{n},��)$ reaction has been studied utilizing epithermal polarized neutrons and germanium detectors. The transverse asymmetry for single $��$-ray transition was measured to be $0.60\pm0.19$ in the $p$-wave resonance.

info:eu-repo/semantics/published

Understanding of $\gamma$-ray production via neutron interactions on oxygen is essential for the study of neutrino neutral-current quasielastic interactions in water Cherenkov detectors. A measurement of $\gamma$-ray production from such reactions was performed using a 77~MeV quasi-monoenergetic neutron beam. Several $\gamma$-ray peaks, which are expected to come from neutron-${\rm ^{16}O}$ reactions, are observed and production cross sections are measured for nine $\gamma$-ray components of energies between 2 and 8~MeV. These are the first measurements at this neutron energy using a nearly monoenergitic beam., Comment: 16 pages, 20 figures, 4 tables

Understanding of $��$-ray production via neutron interactions on oxygen is essential for the study of neutrino neutral-current quasielastic interactions in water Cherenkov detectors. A measurement of $��$-ray production from such reactions was performed using a 77~MeV quasi-monoenergetic neutron beam. Several $��$-ray peaks, which are expected to come from neutron-${\rm ^{16}O}$ reactions, are observed and production cross sections are measured for nine $��$-ray components of energies between 2 and 8~MeV. These are the first measurements at this neutron energy using a nearly monoenergitic beam., 16 pages, 20 figures, 4 tables

In a neutron lifetime measurement at the Japan Proton Accelerator Complex, the neutron lifetime is calculated by the neutron decay rate and the incident neutron flux. The flux is obtained due to counting the protons emitted from the neutron absorption reaction of ${}^{3}{\rm He}$ gas, which is diluted in a mixture of working gas in a detector. Hence, it is crucial to determine the amount of ${}^{3}{\rm He}$ in the mixture. In order to improve the accuracy of the number density of the ${}^{3}{\rm He}$ nuclei, we suggested to use the ${}^{14}{\rm N}({\rm n},{\rm p}){}^{14}{\rm C}$ reaction as a reference because this reaction involves similar kinetic energy as the ${}^{3}{\rm He}({\rm n},{\rm p}){}^{3}{\rm H}$ reaction and a smaller reaction cross section to introduce reasonable large partial pressure. The uncertainty of the recommended value of the cross section, however, is not satisfied with our requirement. In this paper, we report the most accurate experimental value of the cross section of the ${}^{14}{\rm N}({\rm n},{\rm p}){}^{14}{\rm C}$ reaction at a neutron velocity of 2200 m/s, measured relative to the ${}^{3}{\rm He}({\rm n},{\rm p}){}^{3}{\rm H}$ reaction. The result was 1.868 $\pm$ 0.003 (stat.) $\pm$ 0.006 (sys.) b. Additionally, the cross section of the ${}^{17}{\rm O}({\rm n},{\rm \alpha}){}^{14}{\rm C}$ reaction at the neutron velocity is also redetermined as 249 $\pm$ 6 mb., Comment: 22 pages, 11 figures

The dark matter search project by means of ultra high purity NaI(Tl) scintillator is now underdevelopment. An array of large volume NaI(Tl) detectors whose volume is 12.7 cm$\phi\times$12.7 cm is applied to search for dark matter signal. To remove radioactive impurities in NaI(Tl) crystal is one of the most important task to find small number of dark matter signals. We have developed high purity NaI(Tl) crystal which contains small amounts of radioactive impurities, $, Comment: 8 pages, 5 figures. Proceedings of 31st Workshop on Radiation Detector and Their Uses, January 23-25, 2017. KEK, JAPAN

The ($^{11}$B,$^{11}$Li) double charge-exchange reaction (DCER) at $E(^{11}$B)/$A$=80 MeV was measured for the first time to demonstrate the feasibility of the reaction for studying neutrino nuclear responses for double beta decays (DBD). The $^{13}$C($^{11}$B,$^{11}$Li)$^{13}$O reaction shows strengths at the ground state and low and high excitation giant resonance regions. The $^{56}$Fe ($^{11}$B,$^{11}$Li) $^{56}$Ni reaction shows the large strengths in the possible double giant resonance region and beyond, but shows no strengths in the low excitation region below 5 MeV, suggesting strong concentration of the DBD strength at the high excitation region. The DCER is used to evaluate the spin isospin strengths relevant to DBD responses., 6 pages, 3 figures

In this document, the technical details of the JSNS$^2$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) experiment are described. The search for sterile neutrinos is currently one of the hottest topics in neutrino physics. The JSNS$^2$ experiment aims to search for the existence of neutrino oscillations with $\Delta m^2$ near 1 eV$^2$ at the J-PARC Materials and Life Science Experimental Facility (MLF). A 1 MW beam of 3 GeV protons incident on a spallation neutron target produces an intense neutrino beam from muon decay at rest. Neutrinos come predominantly from $\mu^+$ decay: $\mu^{+} \to e^{+} + \bar{\nu}_{\mu} + \nu_{e}$. The experiment will search for $\bar{\nu}_{\mu}$ to $\bar{\nu}_{e}$ oscillations which are detected by the inverse beta decay interaction $\bar{\nu}_{e} + p \to e^{+} + n$, followed by gammas from neutron capture on Gd. The detector has a fiducial volume of 17 tons and is located 24 meters away from the mercury target. JSNS$^2$ offers the ultimate direct test of the LSND anomaly. In addition to the sterile neutrino search, the physics program includes cross section measurements with neutrinos with a few 10's of MeV from muon decay at rest and with monochromatic 236 MeV neutrinos from kaon decay at rest. These cross sections are relevant for our understanding of supernova explosions and nuclear physics.

The negative-muon capture reaction (MCR) on the enriched $^{100}Mo$ isotope was studied for the first time to investigate neutrino nuclear response for neutrino-less double beta decays and supernova neutrino nuclear interactions. MCR on $^{100}Mo$ proceeds mainly as $^{100}Mo(mu,xn)^{100-x}Nb$ with $x$ being the number of neutrons emitted from MCR. The Nb isotope mass distribution was obtained by measuring delayed gamma-rays from radioactive $^{100-x}Nb$. By using the neutron emission model after MCR, the neutrino response (the strength distribution) for MCR was derived. Giant resonance (GR)-like distribution at the peak energy around 11-14 MeV, suggests concentration of the MCR strength at the muon capture GR region., Comment: 5 pages, 6 figures

The γ-ray strength functions and level densities of Ge73,74 have been extracted up to the neutron-separation energy Sn from particle-γ coincidence data using the Oslo method. Moreover, the γ-ray strength function of Ge74 above Sn has been determined from photoneutron measurements; hence these two experiments cover the range of Eγ≈1-13 MeV for Ge74. The obtained data show that both Ge73,74 display an increase in strength at low γ energies. The experimental γ-ray strength functions are compared with M1 strength functions deduced from average B(M1) values calculated within the shell model for a large number of transitions. The observed low-energy enhancements in Ge73,74 are adopted in the calculations of the Ge72,73(n,γ) cross sections, where there are no direct experimental data. Calculated reaction rates for more neutron-rich germanium isotopes are shown to be strongly dependent on the presence of the low-energy enhancement.

The JSNS2 (J-PARC E56) experiment aims to search for sterile neutrinos at the J-PARC Materials and Life Sciences Experimental Facility (MLF).After the submission of a proposal to the J-PARC PAC, stage-1 approval was granted to the JSNS2 experiment. The approval followed a series of background measurements which were performed in 2014. Subsequent for stage-1 approval, the JSNS2 collaboration has made continuous efforts to write a Technical Design Report (TDR).This TDR will include two major items as discussed in the previous status report for the 20th J-PARC PAC: (1) A realistic detector location (2) Well understood and realistic detector performance using simulation studies, primarily in consideration of fast neutron rejection. Since August we have been in discussions with MLF staff regarding an appropriate detector location. We are also in the process of setting up a Monte Carlo (MC) simulation framework in order to study detector's performance in realistic conditions. In addition, we have pursued hardware R&D work for the liquid scintillator (LS) and to improve the dynamic range of the 10" photomultiplier tubes (PMTs). The LS R&D works includes Cherenkov studies inside the LS, and a Pulse Shape Discrimination (PSD) study with a test-beam, performed at Tohoku University. We also estimate the PSD performance of a full-sized detector using a detailed MC simulation. In this status report, we describe progress on this work.

The $\gamma$-ray strength functions and level densities of $^{73,74}$Ge have been extracted up to the neutron separation energy S$_n$ from particle-$\gamma$ coincidence data using the Oslo method. Moreover, the $\gamma$-ray strength function of $^{74}$Ge above S$_n$ has been determined from photo-neutron measurements, hence these two experiments cover the range of E$_\gamma \approx$ 1-13 MeV for $^{74}$Ge. The obtained data show that both $^{73,74}$Ge display an increase in strength at low $\gamma$ energies. The experimental $\gamma$-ray strength functions are compared with $M1$ strength functions deduced from average $B(M1)$ values calculated within the shell model for a large number of transitions. The observed low-energy enhancements in $^{73,74}$Ge are adopted in the calculations of the $^{72,73}$Ge(n,$\gamma$) cross sections, where there are no direct experimental data. Calculated reaction rates for more neutron-rich germanium isotopes are shown to be strongly dependent on the presence of the low-energy enhancement.