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Background and Study Aim. The physical training of young athletes is the basis for future success in competitions. Its effectiveness depends on many factors, among which safe conditions for life support stand out. In the context of the COVID-19 pandemic, there are significant restrictions on the training of young athletes. The aim of the study is the physical training of young Greco-Roman wrestlers in the context of the COVID-19 pandemic. Material and Methods. The study involved young athletes (boys, n=20, age 5-7 years (Kharkiv, Ukraine). The experimental group of initial training (n=10) consisted of young athletes of the first year of study (children's sports school). The control group (n=10) consisted of children in the first year of primary school education. The study was conducted for 12 weeks. At the beginning and at the end of the study, a final testing of the level of physical fitness of boys was carried out. Tests were used to determine strength abilities, speed-strength abilities, coordination readiness and flexibility development. The study included all students whose parents agreed to participate in the study. This study was conducted by the Declaration of Helsinki and approved by the Ethics Committee of University. Results. Positive changes in the experimental group were observed in tests characterizing the level of development of coordination abilities. During repeated testing, the experimental group was much better oriented in space when performing three rolls. This was manifested in a reduction in the time of their implementation (t=4.091; р˂0.001) and a longer balance in static conditions (t=4.11; р˂0.01). In tests for the manifestation of strength and coordination abilities, there is a tendency to positive changes. However, there was no confirmation of a likely difference between pre-test and post-test (p>0.05). In tests for flexibility, the result remained almost unchanged and even deteriorated slightly. There were very slight positive changes in other studied indicators. Conclusions. For the formation of basic physical fitness, it is effective to provide a greater variety of training means and to maximize the focus on the game method of training. The process of training wrestlers of this age should be directed mainly to the development of coordination abilities.

DosS is a heme-sensor histidine kinase that responds to redox-active stimuli in mycobacterial environments by triggering dormancy transformation. Sequence comparison of the catalytic ATP-binding (CA) domain of DosS to other well-studied histidine kinases suggests that it possesses a rather short ATP-lid. This feature has been thought to inhibit DosS kinase activity by blocking ATP binding in the absence of interdomain interactions with the dimerization and histidine phospho-transfer (DHp) domain of full-length DosS. Here, we use a combination of computational modeling, structural biology, and biophysical studies to re-examine ATP-binding modalities in DosS’s CA domain. We show that the closed lid conformation observed in protein crystal structures of DosS CA is caused by the presence of a zinc cation in the ATP binding pocket that coordinates with a glutamate residue on the ATP-lid. Furthermore, circular dichroism (CD) studies and comparisons of DosS CA crystal structure with its AlphaFold model and homologous DesK reveal that a key N-box alpha-helix turn of the ATP pocket manifests as a random coil in the zinc-coordinated protein crystal structure. We note that this closed lid conformation and the random-coil transformation of an N-box alpha-helix turn are artifacts arising from the millimolar zinc concentration used in DosS CA crystallization conditions. In contrast, in the absence of zinc, we find that the short ATP-lid of DosS CA has significant conformational flexibility and can bind ATP ( K (d) = 53 ± 13 μM). We conclude that DosS CA is almost always bound to ATP under physiological conditions (1-5 mM ATP, sub-nanomolar free zinc) in the bacterial environment. Our findings elucidate the conformational adaptability of the short ATP-lid, its relevance to ATP binding in DosS CA and provide insights that extends to 2988 homologous bacterial proteins containing such ATP-lids.

Objective: Clinical trials have reported that Huaier granule inhibits the recurrence of hepatocellular carcinoma (HCC) after resection. However, its efficacy in patients at different clinical stages of HCC remains unknown. We investigated the effects of Huaier granule on the 3-year overall survival (OS) rate of patients at different clinical stages.Design: This cohort study included 826 patients with HCC, screened between January 2015 and December 2019. The patients were divided into Huaier (n = 174) and control groups (n = 652), and the 3-year OS rates were compared between the two groups. To eliminate bias caused by confounding factors, propensity score matching (PSM) was performed. We used the Kaplan-Meier method to estimate OS rate and tested the difference using the log-rank test.Results: Multivariable regression analysis revealed that Huaier therapy was an independent protective factor for 3-year survival rate. After PSM (1:2), the Huaier and control groups comprised 170 and 340 patients, respectively. The 3-year OS rate was remarkably higher in the Huaier group than in the control group (adjusted hazard ratio [aHR]: 0.36; 95% confidence interval: 0.26–0.49; p < 0.001). The aHR for Huaier use for 3–12, 12–24, and >24 months was 0.48, 0.23, and 0.16, respectively, indicating a dose-response pattern. For the 3–12-, 12–24-, and >24-month groups, the 3-year OS rate was 54.1%, 68.6%, and 90.4%, respectively. Multivariate stratified analysis confirmed that the mortality risk in Huaier users was lower than that in non-Huaier users in most subgroups.Conclusion: Adjuvant Huaier therapy improved the OS rate in patients with HCC. However, these findings require further verification through prospective clinical studies.

BackgroundInflammatory responses and lipid metabolism disorders contribute to the development and prognosis of hepatocellular carcinoma (HCC). This study aimed to investigate the prognostic value of lipid-related inflammatory parameters in patients with HCC.MethodsFrom January 2010 to June 2017, we enrolled 1,639 patients with HCC at Beijing Ditan Hospital. Multivariate Cox regression analysis and area under the receiver operating characteristic (AUC) analysis were used to evaluate and compare the predictability and reliability of high-density lipoprotein cholesterol (HDL-C), neutrophil-to-HDL-C ratio (NHR), monocyte-to-HDL-C ratio (MHR), and lymphocyte-to-HDL-C ratio (LHR) values. A restricted cubic spline was used to explore the association between the NHR and 3-year mortality in patients with HCC. Differences in survival rates were estimated using the Kaplan–Meier method and compared using the log-rank test. The results were validated in an internal cohort between July 2017 and October 2019 (n = 373).ResultsAfter adjusting for confounding variables, NHR was independently associated with 3-year mortality, both as a continuous and categorical variable (both p ConclusionBaseline NHR is a promising prognostic parameter for mortality in patients with HCC and patients with NHR ≥ 3.5 and MELD ≥9 have a high mortality rate.

$L^1$ based optimization is widely used in image denoising, machine learning and related applications. One of the main features of such approach is that it naturally provide a sparse structure in the numerical solutions. In this paper, we study an $L^1$ based mixed DG method for second-order elliptic equations in the non-divergence form. The elliptic PDE in nondivergence form arises in the linearization of fully nonlinear PDEs. Due to the nature of the equations, classical finite element methods based on variational forms can not be employed directly. In this work, we propose a new optimization scheme coupling the classical DG framework with recently developed $L^1$ optimization technique. Convergence analysis in both energy norm and $L^{\infty}$ norm are obtained under weak regularity assumption. Such $L^1$ models are nondifferentiable and therefore invalidate traditional gradient methods. Therefore all existing gradient based solvers are no longer feasible under this setting. To overcome this difficulty, we characterize solutions of $L^1$ optimization as fixed-points of proximity equations and utilize matrix splitting technique to obtain a class of fixed-point proximity algorithms with convergence analysis. Various numerical examples are displayed to illustrate the numerical solution has sparse structure with careful choice of the bases of the finite dimensional spaces. Numerical examples in both smooth and nonsmooth settings are provided to validate the theoretical results.

The aim of this review is to identify what evidence currently exists which explores Chinese International students’ mental health and psychological wellbeing in western universities. More specifically, we aim to describe and synthesise: (a) Evidence for the prevalence and range of diagnosed mental health disorders and those experiencing subthreshold symptoms and (b)Evidence of the effectiveness of psychological interventions or preventions in reducing symptoms of mental health disorders and mental health challenges in Chinese international students.

Purpose Methods and materials Results Conclusion Personal information and conflict of interest References, Purpose: Insulin is commonly used in type 2 diabetes mellitus (T2DM) to achieve glycemic control. However, recent evidence showed that insulin use is associated with poor outcomes in the context of heart failure (HF) [1-5]. Since heart failure with reduced...

The advent and fast development of neural networks have revolutionized the research on dialogue systems and subsequently have triggered various challenges regarding their automatic evaluation. Automatic evaluation of open-domain dialogue systems as an open challenge has been the center of the attention of many researchers. Despite the consistent efforts to improve automatic metrics' correlations with human evaluation, there have been very few attempts to assess their robustness over multiple domains and dimensions. Also, their focus is mainly on the English language. All of these challenges prompt the development of automatic evaluation metrics that are reliable in various domains, dimensions, and languages. This track in the 11th Dialogue System Technology Challenge (DSTC11) is part of the ongoing effort to promote robust and multilingual automatic evaluation metrics. This article describes the datasets and baselines provided to participants and discusses the submission and result details of the two proposed subtasks.

Protein oxidation during food processing causes changes in the balance of protein-molecular interactions and protein-water interactions, ultimately leading to protein denaturation, which leads to the loss of a range of functional properties. Therefore, how to control the oxidative modification of proteins during processing has been the focus of research.In this study, the intrinsic fluorescence value of the myofibrillar proteins (MP) decreased and the surface hydrophobicity value increased, indicating that the heat treatment caused a significant change in the conformation of the MP. With the increase of heating temperature, protein carbonyl content increased, total sulfhydryl content decreased, and protein secondary structure changed from α-helix to β-sheet, indicating that protein oxidation and aggregation occurred. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) result showed that heat treatment can lead to the degradation of proteins, especially myosin heavy chain, but actin had a certain thermal stability. A total of 733 proteins were identified by proteomics, and the protein oxidation caused by low temperature vacuum heating (LTVH) was determined to be mild oxidation dominated by malondialdehyde and 4-hydroxynonenal by oxidation site division.This study revealed the effect of LTVH treatment on the protein oxidation modification behavior of sturgeon meat, and explored the effect mechanism of LTVH treatment on the processing quality of sturgeon meat from the perspective of protein oxidation. This result of this study may provide a theoretical basis for the precise processing of aquatic products. This article is protected by copyright. All rights reserved.

The wavelet transform cannot maintain a balance in image edge preservation and detail processing and the multi-scale Retinex algorithm is prone to halo artifacts and serious noise pollution in images. In order to solve the above problems, a mine low illumination image enhancement algorithm is proposed by combining the wavelet transform with the multi-scale Retinex algorithm based on multi-scale guided filtering. Firstly, the algorithm decomposes the low illumination image into wavelets to obtain the high-frequency and low-frequency components. Secondly, the wavelet denoising is applied to the high-frequency components of the image using a three-stage threshold function, and nonlinear global luminance correction is applied to the low-frequency components of the image to enhance the image luminance. Moreover, the multi-scale guided filter function is used to estimate the illumination components instead of the Gaussian filter function of the traditional multi-scale Retinex algorithm, and then the reflection components are obtained. The principal component analysis method is used to fuse the reflection component and the non-linear global luminance correction image so as to improve image edge detail preservation effect effectively. Finally, the wavelet reconstruction is performed on the high-frequency components and low-frequency components of the image, and the wavelet reconstructed image is nonlinearly transformed to solve the image graying problem. The experimental results show that the algorithm has strong noise suppression capability, can improve the image luminance and contrast effectively, make the image edge preservation performance and detail information richness effectively balanced, and avoid the image halo artifacts and color distortion.

Excessive intake of high-caffeine tea will induce health-related risk. Therefore, breeding and cultivating tea cultivars with less caffeine is a feasible way to control daily caffeine intake. Cocoa tea (

Objective to observe the clinical effect of electroacupuncture on postpartum urinary retention (PPUR) through a randomized controlled study. Methods seventy-two PPUR puerperae who met the inclusion criteria were divided into the observation group (electroacupuncture at Ciliao (次髎BL32) and Zhōngliao (中髎BL33) group) and the control group (sham acupuncture group) according to the random number table method, with 36 cases in each. Urine catheters were retained. After 3 days of treatment, the therapeutic effect of PPUR was compared between the two groups. Results in the observation group, the first urination time was significantly earlier than that in the control group, the first urination volume was significantly more than that in the control group, the bladder residual urine volume was significantly less than that in the control group, and the urinary infection was significantly less than that in the control group, the differences were statistically significant (all P Conclusion the therapeutic value of electroacupuncture at BL32 and BL33 for primiparae with PPUR is significantly obvious. This therapy is worthy of clinical promotion.

Sophisticated spin instruments require high-precision spin control. In this study, we accurately study the intrinsic magnetic properties of the strongly disordered system NdFe0.5Cr0.5O3 through molecular field models combined with ASD theory. The three constituent sub-magnetic phases of the system are separated, and their magnetization contributions are calculated separately. Fitting the angle of the A/B magnetic moment at a given temperature, the reorientation temperature point and temperature dependence of different magnetic phases are obtained. This research will provide a very good theoretical support for studying complex disordered systems and applying high-precision spin control and lay a foundation for the design of new functional materials.

Objective To evaluate the clinical effect of electroacupuncture treatment for chloasma in young and middle-aged women. Methods Sixty young and middle-aged female patients with chloasma were divided into treatment group (n = 30) and control group (n = 30) according to random number table. In the treatment group, the electroacupuncture was applied to the facial acupoints and “Vagus” in the cavity of concha in the ear. The selection of facial acupoints was relating to the running course of facial nerve trunk: Yifēng (翳风 TE17), Shangguān (上关 GB3)—Sīzhukōng (丝竹空 TE 23) (Temporal branch), Xiaguān (下关 ST7)—Sibai (四白 ST2) (Zygomatic branch), Qiānzheng (牵正 Extra) —Quanliao (颧髎 SI18) (Zygomatic branch), Jiāchē (颊车 ST6) —Jiāchengjiāng (夹承浆Extra) (Buccal branch), Hegǔ (合谷LI 4). Electro-stimulation was adopted at “Vagus” in the cavity of concha in the ear (two distribution points of the vagus in the cavity of concha of each ear). The control group received conventional acupuncture (surrounding method of needling at the Ashi points in the facial lesion area and 15 acupoints which were selected in the highest frequency in the conventional acupuncture treatment). After 8 weeks of treatment, the clinical effects were compared.The total score of facial skin lesion, score of skin lesion color, score of lesion area, and effective rate of treatment for chloasma were used to evaluate the clinical effect of the two groups before and after treatment. Results After treatment, the effective rate of the treatment group was 95.00%, that of the control group was 67.50%. The effect of the treatment group was better than that of the control group, and the difference was statistically significant (χ2 = 9.928, P = 0.002). Before treatment, there was no difference in the area score, color score, and total score of skin lesions between the two groups (P>0.05). After treatment, the area score, color score, and total score of skin lesions in the treatment group were (1.05±0.64), (1.05±0.64), and (2.10±0.98) points respectively, while those in the control group were (1.38±0.63), (1.28±0.75), and (2.65±1.19) points respectively.The area score, color score, and total score of skin lesions in the treatment group were lower than those in the control group, with statistically significant differences (all P Conclusion electroacupuncture is more effective than conventional acupuncture in treating chloasma in young and middle-aged women.

The digestion properties of sturgeon myofibrillar protein (MF) treated by low temperature vacuum heating (LTVH) at different processing temperatures (50, 60 and 70 °C) and times (15 and 30 min) were studied and compared with those of sturgeon MF treated by traditional cooking (TC). The results showed that as the temperature and time increased, the protein digestibility decreased, whereas the particle size and protein aggregation increased. It was observed that the band intensity of myosin heavy chain and myosin heavy chain 7 weakened; however, the band intensity of actin showed little change. MALDI-TOF-MS analysis revealed that the digested products of the samples treated by LTVH had a larger proportion of 750-1000 Da peptides than those treated by TC, which was consistent with the trend of the number of unique peptides identified in each group. Fourier transmission infrared (FT-IR) spectroscopy showed that the contents of α-helices and β-sheets exhibited negative and positive correlations with the temperature, respectively. Overall, compared to TC, LTVH can relieve the heat stress of protein conformation, reduce protein aggregation to improve the accessibility of the protein to digestive protease, and increase digestibility.

In this work, the binding mechanism of myofibrillar protein (MP) with malondialdehyde and 4-hydroxy-2-nonenal under low temperature vacuum heating was investigated

Purpose: Serum phosphorus is reported to be associated with insulin resistance (IR) and testosterone in many populations. However, studies exploring the role of serum phosphorus in polycystic ovary syndrome (PCOS) patients are rare. Thus, we aimed to investigate the associations of serum phosphorus concentrations with IR and hyperandrogenemia (HA) in women with PCOS.Methods: This was a secondary analysis of a multicenter and large-sample clinical trial including 1000 PCOS subjects diagnosed by the modified Rotterdam criteria. A total of 508 normal-weight PCOS patients with available serum phosphorus data were enrolled in the present study. Serum phosphorus, metabolic indices, and total testosterone (TT) concentration were measured. IR status was defined by a homeostasis model assessment of insulin resistance (HOMA‐IR) ≥ 2.69, and HA status was defined as a TT level ≥ 1.67 nmol/L. Multivariable linear regression and logistic regression models were used to evaluate the associations of serum phosphorus with IR and HA.Results: Multiple linear regression analysis showed that the serum phosphorus concentration was inversely correlated with fasting plasma glucose (FPG), fasting insulin (FIN), HOMA‐IR, and TT (P trend < 0.05 for all) after adjusting for confounding factors. Logistic regression showed that the serum phosphorus concentration was negatively correlated with IR and HA status. The multivariable-adjusted odds ratios with 95% confidence intervals for IR and HA status for the lowest vs. the highest quartiles of serum phosphorus were 2.26 (1.17-4.35, P trend = 0.009) and 2.58 (1.48–4.51, P trend = 0.002), respectively. Conclusion: Our results demonstrated that lower serum phosphorus concentrations were associated with higher risk of IR and worsened HA in normal-weight women with PCOS.

Objective To develop and test computer software to detect, quantify, and monitor progression of pneumonia associated with COVID-19 using chest CT scans. Methods One hundred twenty chest CT scans from subjects with lung infiltrates were used for training deep learning algorithms to segment lung regions and vessels. Seventy-two serial scans from 24 COVID-19 subjects were used to develop and test algorithms to detect and quantify the presence and progression of infiltrates associated with COVID-19. The algorithm included (1) automated lung boundary and vessel segmentation, (2) registration of the lung boundary between serial scans, (3) computerized identification of the pneumonitis regions, and (4) assessment of disease progression. Agreement between radiologist manually delineated regions and computer-detected regions was assessed using the Dice coefficient. Serial scans were registered and used to generate a heatmap visualizing the change between scans. Two radiologists, using a five-point Likert scale, subjectively rated heatmap accuracy in representing progression. Results There was strong agreement between computer detection and the manual delineation of pneumonic regions with a Dice coefficient of 81% (CI 76–86%). In detecting large pneumonia regions (> 200 mm3), the algorithm had a sensitivity of 95% (CI 94–97%) and specificity of 84% (CI 81–86%). Radiologists rated 95% (CI 72 to 99) of heatmaps at least “acceptable” for representing disease progression. Conclusion The preliminary results suggested the feasibility of using computer software to detect and quantify pneumonic regions associated with COVID-19 and to generate heatmaps that can be used to visualize and assess progression. Key Points • Both computer vision and deep learning technology were used to develop computer software to quantify the presence and progression of pneumonia associated with COVID-19 depicted on CT images. • The computer software was tested using both quantitative experiments and subjective assessment. • The computer software has the potential to assist in the detection of the pneumonic regions, monitor disease progression, and assess treatment efficacy related to COVID-19. Electronic supplementary material The online version of this article (10.1007/s00330-020-07156-2) contains supplementary material, which is available to authorized users.

To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. We retrospectively collected chest CT exams including n = 498 on 151 unique patients RT-PCR positive for COVID-19 and n = 497 unique patients with community-acquired pneumonia (CAP). Both COVID-19 and CAP image sets were partitioned into three groups for training, validation, and testing respectively. In an attempt to discriminate COVID-19 from CAP, we developed several classifiers based on three-dimensional (3D) convolutional neural networks (CNNs). We also asked two experienced radiologists to visually interpret the testing set and discriminate COVID-19 from CAP. The classification performance of the computer algorithms and the radiologists was assessed using the receiver operating characteristic (ROC) analysis, and the nonparametric approaches with multiplicity adjustments when necessary. One of the considered models showed non-trivial, but moderate diagnostic ability overall (AUC of 0.70 with 99% CI 0.56–0.85). This model allowed for the identification of 8–50% of CAP patients with only 2% of COVID-19 patients. Professional or automated interpretation of CT exams has a moderately low ability to distinguish between COVID-19 and CAP cases. However, the automated image analysis is promising for targeted decision-making due to being able to accurately identify a sizable subsect of non-COVID-19 cases. • Both human experts and artificial intelligent models were used to classify the CT scans. • ROC analysis and the nonparametric approaches were used to analyze the performance of the radiologists and computer algorithms. • Unique image features or patterns may not exist for reliably distinguishing all COVID-19 from CAP; however, there may be imaging markers that can identify a sizable subset of non-COVID-19 cases.

l-Leucine is an essential amino acid that has wide and expanding applications in the industry. It is currently fast-growing market demand that provides a powerful impetus to further increase its bioconversion productivity and production stability. In this study, we rationally engineered the metabolic flux from pyruvate to l-leucine synthesis in Corynebacterium glutamicum to enhance both pyruvate availability and l-leucine synthesis. First, the pyc (encoding pyruvate carboxylase) and avtA (encoding alanine-valine aminotransferase) genes were deleted to weaken the metabolic flux of the tricarboxylic acid cycle and reduce the competitive consumption of pyruvate. Next, the transcriptional level of the alaT gene (encoding alanine aminotransferase) was down regulated by inserting a terminator to balance l-leucine production and cell growth. Subsequently, the genes involved in l-leucine biosynthesis were overexpressed by replacing the native promoters PleuA and PilvBNC of the leuA gene and ilvBNC operon, respectively, with the promoter Ptuf of eftu (encoding elongation factor Tu) and using a shuttle expression vector. The resulting strain WL-14 produced 28.47 ± 0.36 g/L l-leucine in shake flask fermentation.

Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa, as well as providing new information of fungal taxa worldwide. This article is the 11th contribution to the fungal diversity notes series, in which 126 taxa distributed in two phyla, six classes, 24 orders and 55 families are described and illustrated. Taxa in this study were mainly collected from Italy by Erio Camporesi and also collected from China, India and Thailand, as well as in some other European, North American and South American countries. Taxa described in the present study include two new families, 12 new genera, 82 new species, five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual reports. The two new families areEriomycetaceae(Dothideomycetes, familyincertae sedis) andFasciatisporaceae(Xylariales, Sordariomycetes). The twelve new genera compriseBhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),Eriocamporesia(Cryphonectriaceae),Eriomyces(Eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae, genusincertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae) andXenoanthostomella(Xylariales, generaincertae sedis). The 82 new species compriseAcremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispora,Cytospora rosigena,Diaporthe camporesii,Diaporthe nigra,Diatrypella yunnanensis,Dictyosporium muriformis,Didymella camporesii,Diutina bernali,Diutina sipiczkii,Eriocamporesia aurantia,Eriomyces heveae,Ernakulamia tanakae,Falciformispora uttaraditensis,Fasciatispora cocoes,Foliophoma camporesii,Fuscostagonospora camporesii,Helvella subtinta,Kalmusia erioi,Keissleriella camporesiana,Keissleriella camporesii,Lanspora cylindrospora,Loratospora arezzoensis,Mariannaea atlantica,Melanographium phoenicis,Montagnula camporesii,Neodidymelliopsis camporesii,Neokalmusia kunmingensis,Neoleptosporella camporesiana,Neomonodictys muriformis,Neomyrmecridium guizhouense,Neosetophoma camporesii,Paraloratospora camporesii,Paramonodictys solitarius,Periconia palmicola,Plenodomus triseptatus,Pseudocamarosporium camporesii,Pseudocercospora maetaengensis,Pseudochaetosphaeronema kunmingense,Pseudoconlarium punctiforme,Pseudodactylaria camporesiana,Pseudomurilentithecium camporesii,Pseudotetraploa rajmachiensis,Pseudotruncatella camporesii,Rhexocercosporidium senecionis,Rhytidhysteron camporesii,Rhytidhysteron erioi,Septoriella camporesii,Setoapiospora thailandica,Srinivasanomyces kangrensis,Tetraploa dwibahubeeja,Tetraploa pseudoaristata,Tetraploa thrayabahubeeja,Torula camporesii,Tremateia camporesii,Tremateia lamiacearum,Uzbekistanica pruni,Verruconis mangrovei,Wilcoxina verruculosa,Xenoanthostomella chromolaenaeandXenodidymella camporesii. The five new combinations areCamporesiomyces patagoniensis,Camporesiomyces vaccinia,Camposporium lycopodiellae,Paraloratospora gahniaeandRhexocercosporidium microsporum. The 22 new records on host and geographical distribution compriseArthrinium marii,Ascochyta medicaginicola,Ascochyta pisi,Astrocystis bambusicola,Camposporium pellucidum,Dendryphiella phitsanulokensis,Diaporthe foeniculina,Didymella macrostoma,Diplodia mutila,Diplodia seriata,Heterosphaeria patella,Hysterobrevium constrictum,Neodidymelliopsis ranunculi,Neovaginatispora fuckelii,Nothophoma quercina,Occultibambusa bambusae,Phaeosphaeria chinensis,Pseudopestalotiopsis theae,Pyxine berteriana,Tetraploa sasicola,Torula gaodangensisandWojnowiciella dactylidis. In addition, the sexual morphs ofDissoconium eucalyptiandPhaeosphaeriopsis pseudoagavacearumare reported fromLaurus nobilisandYucca gloriosain Italy, respectively. The holomorph ofDiaporthe cynaroidisis also reported for the first time.

Sturgeon is one of the most precious fish resources worldwide. Low temperature vacuum heating (LTVH) has been confirmed as a good way of maintaining food quality. However, there is a lack of in-depth studies assessing the impact of LTVH on lipid oxidation and flavor formation.The present study compared the effect of LTVH and traditional cooking on lipid oxidation and flavor of sturgeon fillets. In total, 13 fatty acids were detected, of which polyunsaturated fatty acids content was the highest (P 0.05). LTVH prevented the formation of conjugated diene and thiobarbituric acid reactive substances (P 0.05), as manifested by an increased signal intensity of free radicals of electron spin resonance. The characteristic peaks intensity of lipid by Raman at 970 cmOverall, the results of the present study support the view that LTVH is a healthier way of cooking. © 2022 Society of Chemical Industry.

Background The effect of comorbid hypertension and type 2 diabetes mellitus (T2DM) on coronary artery plaques examined by coronary computed tomography angiography (CCTA) is not fully understood. We aimed to comprehensively assess whether comorbid hypertension and T2DM influence coronary artery plaques using CCTA. Materials and methods A total of 1100 T2DM patients, namely, 277 normotensive [T2DM(HTN−)] and 823 hypertensive [T2DM(HTN +)] individuals, and 1048 normotensive patients without T2DM (control group) who had coronary plaques detected on CCTA were retrospectively enrolled. Plaque type, coronary stenosis, diseased vessels, the segment involvement score (SIS) and the segment stenosis score (SSS) based on CCTA data were evaluated and compared among the groups. Results Compared with patients in the control group, the patients in the T2DM(HTN−) and T2DM(HTN +) groups had more partially calcified plaques, noncalcified plaques, segments with obstructive stenosis, and diseased vessels, and a higher SIS and SSS (all P values 3 (OR = 2.233 and 3.769; both P values 5 (OR = 2.057 and 3.580; both P values 3 (OR = 1.647; P = 0.001) and an SSS > 5 (OR = 1.625; P = 0.001). Conclusion T2DM is related to the presence of partially calcified plaques, obstructive CAD, and more extensive coronary artery plaques. Comorbid hypertension and diabetes further increase the risk of partially calcified plaques, and more extensive coronary artery plaques.

Additional file 2. Additional Tables S1–S6 and Figures S1–S2.

Additional file 1: Table S1. ASCVD Risk Categories and LDL-C Treatment Goals. Table S2. CT scanning parameters. Table S3. Association between risk factors, CAC increase and annual increase in total, calcified, noncalcified, and low-density noncalcified plaque volume. Table S4. Inter- and intra-observer variability of CACs and compositional PV.

A subset $B$ of ring $\mathbb{Z}_n$ is called a $\ell$-covering set if $\{ ab \pmod n \mid 0\leq a \leq \ell, b\in B\} = \mathbb{Z}_n$. We show there exists a $\ell$-covering set of $\mathbb{Z}_n$ of size $O(\frac{n}{\ell}\log n)$ for all $n$ and $\ell$, and how to construct such set. We also show examples where any $\ell$-covering set must have size $\Omega(\frac{n}{\ell}\frac{\log n}{\log \log n})$. The proof uses a refined bound for relative totient function obtained through sieve theory, and existence of a large divisor with linear divisor sum.

Additional file 1: Additional information about the feature selection process.

Additional file 1: Table S1. Association of biscuit consumption with DR incidence in subgroups of confounders

Additional file 1. Details of the search strategy for different databases.

In this study, the sol-gel method synthesized the magnetic measurement and analysis of single-phase polycrystalline perovskite DyFe1-xCrxO3 (DFCO). The experimental data were fitted and calculated by a four-sublattice molecular field model. Unlike previous studies, we found that in DyFe1-xCrxO3, the spin of the A-site rare earth ion Dy3+ also changed simultaneously with the spin reorientation of the Fe3+/Cr3+ ions. The effective spin is defined as the projection of the A site's total spin on the B site's spin plane, and the curve of temperature changes is obtained after fitting. With this theory, a very accurate thermomagnetic curve is obtained by fitting. This is convincing and, at the same time, provides a reference for the development of spintronic devices in the future.

Background Patients with severe acute pancreatitis (SAP) have a high mortality, thus early diagnosis and interventions are critical for improving survival. However, conventional tests are limited in acute pancreatitis (AP) stratification. We aimed to assess AP severity by integrating the informative clinical measurements with cell free DNA (cfDNA) methylation markers. Methods One hundred and seventy-five blood samples were collected from 61 AP patients at multiple time points, plus 24 samples from healthy individuals. Genome-wide cfDNA methylation profiles of all samples were characterized with reduced representative bisulfite sequencing. Clinical blood tests covering 93 biomarkers were performed on AP patients within 24 h. SAP predication models were built based on cfDNA methylation and conventional blood biomarkers separately and in combination. Results We identified 565 and 59 cfDNA methylation markers informative for acute pancreatitis and its severity. These markers were used to develop prediction models for AP and SAP with area under the receiver operating characteristic of 0.92 and 0.81, respectively. Twelve blood biomarkers were systematically screened for a predictor of SAP with a sensitivity of 87.5% for SAP, and a specificity of 100% in mild acute pancreatitis, significantly higher than existing blood tests. An expanded model integrating 12 conventional blood biomarkers with 59 cfDNA methylation markers further improved the SAP prediction sensitivity to 92.2%. Conclusions These findings have demonstrated that accurate prediction of SAP by the integration of conventional and novel blood molecular markers, paving the way for early and effective SAP intervention through a non-invasive rapid diagnostic test.

Excessive intake of high-caffeine tea will induce health-related risk. Therefore, breeding and cultivating tea cultivars with less caffeine is a feasible way to control daily caffeine intake. Cocoa tea (Camellia ptilophylla Chang) is a wild tea plant which grows leaves with little or no caffeine. However, the vegetative propagation of cocoa tea plants is difficult due to challenges with rooting. Whether natural seeds collected from wild cocoa tea plants can be used to produce less-caffeinated tea remains unknown, because research on the separation of traits among the seed progeny population is lacking. The present study was set to investigate the variation of caffeine and other chemical compositions in seed-propagated plant individuals using colorimetric and HPLC methods. It shows that there were great differences in chemical composition among the seed-propagated population of wild cocoa tea plants, among which some individuals possessed caffeine contents as high as those of normal cultivated tea cultivars (C. sinensis), suggesting that the naturally seed-propagated cocoa tea seedlings are not suitable for directly cultivating leaf materials to produce low-caffeine tea. Therefore, the cocoa tea plants used for harvesting seeds for growing low-caffeine tea plants should be isolated in order to prevent their hybridization with normal cultivated C. sinensis plants. Interestingly, the leaves of cocoa tea seedlings contained high levels of gallocatechin gallate (GCG) and would be a good source of leaf materials for extracting more stable antioxidant, because GCG is a more stable antioxidant than epigallocatechin gallate (EGCG), the dominant component of catechins in normal cultivated tea cultivars. Some plant individuals which contained low levels of caffeine along with high levels of amino acids and medium levels of catechins, are considered to be promising for further screening of less-caffeinated green tea cultivars.

A proper lattice structure consisting of homogeneous material is designed in this paper to investigate the maximum bandwidth of perfect lattice structures and tunable property of waveguide with linear geometric defect by means of selecting optimal geometric lattice cell. A simulation model based on finite element method is used to calculate dispersion curves and transmission spectrums of lattice structures with different geometric parameters. Meanwhile, a simplified theoretical model of unit cell, which considers the mass of grid bar and stiffness of node area, is applied to validate the accuracy of simulation result and may provide an effective approach for prediction of band gap lower boundary. Then, the validated numerical results show different orders of widest band gap that can be realized by different optimal geometric structures. Moreover, waveguide property can be effectively controlled and manipulated by changing defect parameters. The present study may establish theoretical and simulation foundation to control and manipulate band structures and other acoustic propagation characteristics of waveguide devices.

An undetermined saprobic fungal taxon from Yunnan (China) is revealed as a new genus in Scortechiniaceae (Coronophorales). The novel taxon, Yuxiensis, is characterized by immersed to erumpent, semi-globose ascomata, which are not surrounded by any tomentum or conspicuous subiculum, a subcylindrical quellkörper in the centrum, clavate asci with long pedicels and allantoid hyaline ascospores with granular contents. Maximum likelihood and Bayesian posterior probability analyses based on LSU, ITS, tef1 and rpb2 sequence data depict a close phylogenetic relationship of the new genus to Pseudocatenomycopsis, hence, confirming its placement in Scortechiniaceae. Parasympodiellaceae, thus far belonging to Parasympodiellales, is transferred to Coronophorales based on multi-gene phylogenetic evidence. Additionally, the incertae sedis monotypic genus Arthrocristula is treated as a synonym of Parasympodiella, with Arthrocristula hyphenata recombined as Parasympodiella hyphenata comb. nov., as the type strain of Arthrocristula hyphenata clusters inside the Parasympodiellaceae clade along with other Parasympodiella taxa.

A female patient with vaginal pain induced by multiple sclerosis was treated by acupuncture. Her chief complaint: pricking vaginal pain during intercourse for 1 year. Electroacupuncture was applied to Shenshū (肾俞 BL23), Huiyang (会阳 BL35), Ciliao (次髎 BL32) and Zhōngliao (中髎 BL33) on lumbosacral region. The disperse wave was adopted firstly, followed by the dense wave in stimulation. The stimulation intensity was determined by the patient's tolerance. The needles were retained for 50 min totally. After 2-month treatment, the sexual function of the patient was recovered to be normal. The sexual activity was normal in 1-year follow-up and vaginal pain was not recurred.

To provide an effective risk assessment of water inrush for coal mine safety production, a BP neural network prediction method for water inrush based on principal component analysis and deep confidence network optimization was proposed. Because deep belief network (DBN) is disadvantaged by a long training time when establishing a high-dimensional data classification model, the principal component analysis (PCA) method is used to reduce the dimensionality of many factors affecting the water inrush of the coal seam floor, thus reducing the number of variables of the research object, redundancy and the difficulty of feature extraction and shortening the training time of the model. Then, a DBN network was used to extract secondary features from the processed nonlinear data, and a more abstract high-level representation was formed by combining low-level features to find the expression of the nonlinear relationship between the characteristics of water in bursts. Finally, a prediction model was established to predict the water inrush in coal mines. The superiority of this method was verified by comparing the prediction of the actual working face with the actual situation in typical mining areas of North China. The prediction accuracy of coal mine water inrush obtained by this algorithm is 94%, while the prediction accuracy of traditional BP algorithm is 70%, and the prediction accuracy of SVM algorithm is 88%.

ObjectiveTo investigate the clinical effect and adverse events of Jinlong capsules combined with Western medicine treatment in the treatment of advanced primary liver cancer. MethodsPubMed, The Cochrane library, CNKI, Wanfang Data, CBM, and VIP were searched for randomized controlled trials (RCTs) on Jinlong capsules combined with Western medicine treatment in the treatment of advanced primary liver cancer published up to May 2019. The patients treated with Jinlong capsules combined with Western medicine treatment were enrolled as intervention group, and those treated with Western medicine treatment alone were enrolled as control group. Data extraction and quality assessment were performed, and RevMan 5.3 was used to perform the Meta-analysis with a fixed or random effects model. ResultsA total of 26 RCTs were included, with a total of 2318 patients (1175 patients in the intervention group and 1143 patients in the control group). The results of the Meta-analysis showed that compared with Western medicine treatment alone, Jinlong capsules combined with Western medicine treatment had significant increases in response rate (relative risk ［RR］=1.36, 95% confidence interval ［CI］: 125-1.49, P＜0.001), 1-year survival rate (RR=1.29, 95%CI: 1.14-1.47, P＜0.001), Karnofsky Performance Scale score (RR=137, 95%CI: 1.19-1.59, P＜0.001), peripheral blood CD3+ T lymphocytes (mean difference ［MD］=11.18, 95%CI: 268-1968, P=0.01), CD4+ T lymphocytes (MD=6.43, 95%CI: 3.82-9.05, P＜0.001), and CD4+/CD8+ ratio (MD=0.31, 95%CI: 026-0.36, P＜0.001), as well as significant reductions in rate of progression (RR=0.41, 95%CI: 0.29-0.57, P＜0001), rate of leucopenia (RR=0.65, 95%CI: 0.57-0.75, P＜0.001), incidence rate of gastrointestinal reactions (RR=0.72, 95%CI: 059-088, P=0.001), and peripheral blood CD8+ T lymphocytes (MD=-4.68, 95% CI: -5.84 to -3.51, P＜0001). ConclusionJinlong capsules combined with Western medicine treatment has a marked clinical effect in the treatment of advanced primary liver cancer with few adverse events and thus holds promise for clinical application.

Objective To investigate the effect of actin binding protein ANLN on the proliferation, apoptosis, migration and invasion of gastric cancer cells in vitro. Methods RT-PCR and Western blot were used to detect the expression of ANLN in gastric cancer cell lines and gastric mucosal cell lines and verify the knockdown of ANLN gene by siRNA. The effect of silenced ANLN gene expression on the migration and invasion abilities of gastric cancer cells was detected by scratch test and Transwell assay. CCK-8 assay, cell fluorescence staining and flow cytometry were used to detect the effects of silent ANLN gene expression on the proliferation and apoptosis of gastric cancer cells. Results The expression of ANLN mRNA and protein in gastric cancer cell line SGC-7901/MGC-803 were significantly higher than those in gastric mucosa cell line GES-1 (P < 0.001). The transfection was successful, and the mRNA and protein expressions in the transfection group were statistically different from those in the control group (P < 0.05). Down-regulating ANLN expression significantly reduced the migration, invasion, proliferation and apoptosis of gastric cancer cells. Conclusion Down-regulating ANLN expression could significantly reduce the infiltration, migration, proliferation and apoptosis of gastric cancer cells.

Cordyceps qingchengensis sp. nov., growing on a cocooned pupa of a silk moth (Lepidoptera: Bombycidae) and collected from southwestern China, is described, illustrated and compared with allied taxa. The species is morphologically similar to C. bifusispora and C. tenuipes, but can be easily separated from the latter two by the unique host and by branched and thicker stroma. Phylogenetic analyses of single ITS and combined SSU, LSU and TEF1-α datasets indicate that it is closely related to C. bifusispora, C. cicadae (Miq.) Massee (Chanhua) and C. tenuipes, but C. qingchengensis has distinct nucleotide differences which support it as new. Taxonomy of C. tenuipes and C. pruinosa is reviewed and C. ninchukispora (≡ Phytocordyceps ninchukispora) is considered as a synonym of C. pruinosa. Ecology and life cycles of C. qingchengensis, C. tenuipes, C. pruinosa and C. ningxiaensis are recorded and inferred. We provide important biological information for C. qingchengensis and its allies.

This article is the tenth series of the Fungal Diversity Notes, where 114 taxa distributed in three phyla, ten classes, 30 orders and 53 families are described and illustrated. Taxa described in the present study include one new family (viz. Pseudoberkleasmiaceae in Dothideomycetes), five new genera (Caatingomyces, Cryptoschizotrema, Neoacladium, Paramassaria and Trochilispora) and 71 new species, (viz. Acrogenospora thailandica, Amniculicola aquatica, A. guttulata, Angustimassarina sylvatica, Blackwellomyces lateris, Boubovia gelatinosa, Buellia viridula, Caatingomyces brasiliensis, Calophoma humuli, Camarosporidiella mori, Canalisporium dehongense, Cantharellus brunneopallidus, C. griseotinctus, Castanediella meliponae, Coprinopsis psammophila, Cordyceps succavus, Cortinarius minusculus, C. subscotoides, Diaporthe italiana, D. rumicicola, Diatrypella delonicis, Dictyocheirospora aquadulcis, D. taiwanense, Digitodesmium chiangmaiense, Distoseptispora dehongensis, D. palmarum, Dothiorella styphnolobii, Ellisembia aurea, Falciformispora aquatic, Fomitiporia carpinea, F. lagerstroemiae, Grammothele aurantiaca, G. micropora, Hermatomyces bauhiniae, Jahnula queenslandica, Kamalomyces mangrovei, Lecidella yunnanensis, Micarea squamulosa, Muriphaeosphaeria angustifoliae, Neoacladium indicum, Neodidymelliopsis sambuci, Neosetophoma miscanthi, N. salicis, Nodulosphaeria aquilegiae, N. thalictri, Paramassaria samaneae, Penicillium circulare, P. geumsanense, P. mali-pumilae, P. psychrotrophicum, P. wandoense, Phaeoisaria siamensis, Phaeopoacea asparagicola, Phaeosphaeria penniseti, Plectocarpon galapagoense, Porina sorediata, Pseudoberkleasmium chiangmaiense, Pyrenochaetopsis sinensis, Rhizophydium koreanum, Russula prasina, Sporoschisma chiangraiense, Stigmatomyces chamaemyiae, S. cocksii, S. papei, S. tschirnhausii, S. vikhrevii, Thysanorea uniseptata, Torula breviconidiophora, T. polyseptata, Trochilispora schefflerae and Vaginatispora palmae). Further, twelve new combinations (viz. Cryptoschizotrema cryptotrema, Prolixandromyces australi, P. elongatus, P. falcatus, P. longispinae, P. microveliae, P. neoalardi, P. polhemorum, P. protuberans, P. pseudoveliae, P. tenuistipitis and P. umbonatus), an epitype is chosen for Cantharellus goossensiae, a reference specimen for Acrogenospora sphaerocephala and new synonym Prolixandromyces are designated. Twenty-four new records on new hosts and new geographical distributions are also reported (i.e. Acrostalagmus annulatus, Cantharellus goossensiae, Coprinopsis villosa, Dothiorella plurivora, Dothiorella rhamni, Dothiorella symphoricarposicola, Dictyocheirospora rotunda, Fasciatispora arengae, Grammothele brasiliensis, Lasiodiplodia iraniensis, Lembosia xyliae, Morenoina palmicola, Murispora cicognanii, Neodidymelliopsis farokhinejadii, Neolinocarpon rachidis, Nothophoma quercina, Peroneutypa scoparia, Pestalotiopsis aggestorum, Pilidium concavum, Plagiostoma salicellum, Protofenestella ulmi, Sarocladium kiliense, Tetraploa nagasakiensis and Vaginatispora armatispora).

This article is the ninth in the series of Fungal Diversity Notes, where 107 taxa distributed in three phyla, nine classes, 31 orders and 57 families are described and illustrated. Taxa described in the present study include 12 new genera, 74 new species, three new combinations, two reference specimens, a re-circumscription of the epitype, and 15 records of sexual-asexual morph connections, new hosts and new geographical distributions. Twelve new genera comprise Brunneofusispora, Brunneomurispora, Liua, Lonicericola, Neoeutypella, Paratrimmatostroma, Parazalerion, Proliferophorum, Pseudoastrosphaeriellopsis, Septomelanconiella, Velebitea and Vicosamyces. Seventy-four new species are Agaricus memnonius, A. langensis, Aleurodiscus patagonicus, Amanita flavoalba, A. subtropicana, Amphisphaeria mangrovei, Baorangia major, Bartalinia kunmingensis, Brunneofusispora sinensis, Brunneomurispora lonicerae, Capronia camelliae-yunnanensis, Clavulina thindii, Coniochaeta simbalensis, Conlarium thailandense, Coprinus trigonosporus, Liua muriformis, Cyphellophora filicis, Cytospora ulmicola, Dacrymyces invisibilis, Dictyocheirospora metroxylonis, Distoseptispora thysanolaenae, Emericellopsis koreana, Galiicola baoshanensis, Hygrocybe lucida, Hypoxylon teeravasati, Hyweljonesia indica, Keissleriella caraganae, Lactarius olivaceopallidus, Lactifluus midnapurensis, Lembosia brigadeirensis, Leptosphaeria urticae, Lonicericola hyaloseptispora, Lophiotrema mucilaginosis, Marasmiellus bicoloripes, Marasmius indojasminodorus, Micropeltis phetchaburiensis, Mucor orantomantidis, Murilentithecium lonicerae, Neobambusicola brunnea, Neoeutypella baoshanensis, Neoroussoella heveae, Neosetophoma lonicerae, Ophiobolus malleolus, Parabambusicola thysanolaenae, Paratrimmatostroma kunmingensis, Parazalerion indica, Penicillium dokdoense, Peroneutypa mangrovei, Phaeosphaeria cycadis, Phanerochaete australosanguinea, Plectosphaerella kunmingensis, Plenodomus artemisiae, P. lijiangensis, Proliferophorum thailandicum, Pseudoastrosphaeriellopsis kaveriana, Pseudohelicomyces menglunicus, Pseudoplagiostoma mangiferae, Robillarda mangiferae, Roussoella elaeicola, Russula choptae, R. uttarakhandia, Septomelanconiella thailandica, Spencermartinsia acericola, Sphaerellopsis isthmospora, Thozetella lithocarpi, Trechispora echinospora, Tremellochaete atlantica, Trichoderma koreanum, T. pinicola, T. rugulosum, Velebitea chrysotexta, Vicosamyces venturisporus, Wojnowiciella kunmingensis and Zopfiella indica. Three new combinations are Baorangia rufomaculata, Lanmaoa pallidorosea and Wojnowiciella rosicola. The reference specimens of Canalisporium kenyense and Tamsiniella labiosa are designated. The epitype of Sarcopeziza sicula is re-circumscribed based on cyto- and histochemical analyses. The sexual-asexual morph connection of Plenodomus sinensis is reported from ferns and Cirsium for the first time. In addition, the new host records and country records are Amanita altipes, A. melleialba, Amarenomyces dactylidis, Chaetosphaeria panamensis, Coniella vitis, Coprinopsis kubickae, Dothiorella sarmentorum, Leptobacillium leptobactrum var. calidus, Muyocopron lithocarpi, Neoroussoella solani, Periconia cortaderiae, Phragmocamarosporium hederae, Sphaerellopsis paraphysata and Sphaeropsis eucalypticola., Rungtiwa Phookamsak thanks CAS President’s International Fellowship Initiative (PIFI) for Young Staff 2019–2021 (grant number 2019FY0003), the Research Fund from China Postdoctoral Science Foundation (Grant No. Y71B283261), the Yunnan Provincial Department of Human Resources and Social Security (Grant No. Y836181261), and National Science Foundation of China (NSFC) project code 31850410489 for financial research support. Kevin D. Hyde thanks the Foreign Experts Bureau of Yunnan Province, Foreign Talents Program (2018; Grant No. YNZ2018002), Thailand Research grants entitled Biodiversity, phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans (Grant No: RSA5980068), the future of specialist fungi in a changing climate: baseline data for generalist and specialist fungi associated with ants, Rhododendron species and Dracaena species (Grant No: DBG6080013), Impact of climate change on fungal diversity and biogeography in the Greater Mekong Subregion (Grant No: RDG6130001). Jianchu Xu thanks the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (Grant No. QYZDY-SSW-SMC014). Peter E Mortimer would like to thank the National Science Foundation of China and the Chinese Academy of Sciences for financial support under the following grants: 41761144055, 41771063 and Y4ZK111B01. Olivier Raspé is grateful to the Fonds de la Recherche Scientifique-FNRS (Belgium) for travel grants. Samantha C. Karunarathna thanks CAS President’s International Fellowship Initiative (PIFI) for funding his postdoctoral research (Grant No. 2018PC0006) and the National Science Foundation of China (NSFC, project code 31750110478). Dhanushaka N. Wanasinghe would like to thank CAS President’s International Fellowship Initiative (PIFI) for funding his postdoctoral research (Grant No. 2019PC0008). E.B. Gareth Jones is supported under the Distinguished Scientist Fellowship Program (DSFP), King Saud University, Kingdom of Saudi Arabia., Aniket Ghosh, Kanad Das, Priyanka Uniyal, Rajendra P. Bhatt, Tahir Mehmood, and Upendra Singh are grateful to the Head, Department of Botany & Microbiology & USIC Dept. HNB Garhwal University, Srinagar Garhwal and thank to the Director, Botanical Survey of India, Kolkata for providing all kinds of facilities during the present study and UGC for providing fellowship to Aniket Ghosh, Priyanka Uniyal and Tahir Mehmood. K. P. Deepna Latha acknowledge the Kerala State Council for Science, Technology and Environment (KSCSTE) in the form of a PhD fellowship (Grant No. 001/FSHP/2011/CSTE) and the Principal Chief Conservator of forests, Kerala State, for granting permission (No. WL10- 4937/2012, dated 03-10-2013) to collect agarics from the forests of Kerala. K. N. Anil Raj thanks the Council of Scientific & Industrial Research (CSIR), New Delhi, India, in the form of an award of CSIR Research Associateship (09/043(0178) 2K17 dated: 31/03/2017). Mao-Qiang He and Rui-Lin Zhao thank the National Natural Science Foundation of China (Project ID: 31470152 and 31360014) and the Foundation of Innovative Group of Edible Mushrooms Industry of Beijing (Project ID:BAIC05-2017). Mingkwan Doilom would like to thank the 5th batch of Postdoctoral Orientation Training Personnel in Yunnan Province and the 64th batch of China Postdoctoral Science Foundation., Tatiana Baptista Gibertoni and Renato Lu´cio Mendes Alvarenga acknowledge Dr. Viacheslav Spirin for the taxonomic and morphological advises, CNPq for the Ph.D scholarship of RLMA (140283/ 2016-1), Po´s-Graduac¸a˜o em Biologia de Fungos (UFPE, Brazil), Capes (Capes-SIU 008/13), CNPq (PQ 307601/2015-3) and FACEPE (APQ 0375-2.03/15) for funding the research. Margarita Duen˜as, M. Teresa Telleria and Marı´a P. Martı´n acknowledge financial support from the Agreement ENDESA and San Ignacio de Huinay Foundations and Consejo Superior de Investigaciones Cientı´ficas, CSIC (Projects No. 2011HUIN10, 2013CL0012, 2014CL0011), the AECID (Agencia Espan˜ola de Cooperacio´n Internacional para el Desarrollo) and Plan Nacional I ? D?i project no. CGL2015–67459–P; to Reinhard Fitzek (San Ignacio del Huinay Foundation, Chile) for his invaluable help during fieldwork, and M. Glenn (Seton Hall University, US) for revising the text and Miguel Jerez and Yolanda Ruiz Leo´n for SEM technical assistance. Sandra Nogal-Prata was supported by a Predoctoral Grant from the Ministerio de Economı´a y Competitividad (Spain) (BES-2016-077793). Armin Mesˇic´ and Zdenko Tkalcˇec thank Croatian Science Foundation for their partial support under the project HRZZ-IP-2018-01-1736 (ForFungiDNA) and are grateful to Milan Cˇ erkez for collecting specimens of coprinoid taxa for this study. Hyang Burm Lee was supported by the Graduate Program for the Undiscovered Taxa of Korea, and the Project on Survey and Discovery of Indigenous Fungal Species of Korea funded by NIBR and Project on Discovery of Fungi from Freshwater and Collection of Fungarium funded by NNIBR of the Ministry of Environment (MOE), and in part carried out with the support of Cooperative Research Program for Agriculture Science and Technology Development (PJ013744), Rural Development Administration, and BK21 PLUS program funded by Ministry of Education, Republic of Korea., Mubashar Raza would like to thank the CASTWAS for the PhD Fellowship. Sanjay K. Singh, Paras Nath Singh, Shiwali Rana and Frank Kwekucher Ackah thank Director, MACS, Agharkar Research Institute, Pune, India for providing facilities. Shiwali Rana and Frank Kwekucher Ackah thank UGC (Junior Research Fellowship) and DST, Govt. of India (CV Raman Fellowship for African Researchers), respectively. Gen-Nuo Wang, Huang Zhang, Wei Dong and Xian-Dong Yu thank the National Natural Science Foundation of China (Project ID: NSF 31500017). Bandarupalli Devadatha and V. Venkateswara Sarma thank The Ministry of Earth sciences, Govt. of India (Sanction order: MOES/36/OO1S/ Extra/40/2014/PC-IV dt.14.1.2015) for a funding of the project, T, District Forest Office, Tiruvarur, Tamil Nadu and PCCF (Head of Forest Force), Chennai, Tamil Nadu Forest Department for providing permission to collect samples from Muthupet mangroves, and Department of Biotechnology, Pondicherry University is thanked for providing the facilities. Myung Soo Park, Seung-Yoon Oh and Young Woon Lim thank the Marine Bio Resource Bank Program of the Ministry of Ocean & Fisheries, Korea. Olinto Pereira thanks the CAPES, CNPq and FAPEMIG for financial support. Neven Matocˇec, Ivana Kusˇan and Margita Jadan express their gratitude to Livio Lorenzon, Enrico Bizio and Raffaella Trabucco (MCVE) for their kind help with loan of Sarcopeziza sicula type material; parts of their, research were financed by Public Institutions Sjeverni Velebit National Park and Paklenica National Park. Dong-Qin Dai and LiZhou Tang thank the National Natural Science Foundation of China (No. NSFC 31760013, NSFC 31260087, NSFC 31460561), the Scientific Research Foundation of Yunnan Provincial Department of Education (2017ZZX186) and utilization of endophytes and the Thousand Talents Plan, Youth Project of Yunnan Provinces. Ting-Chi Wen, Chada Norphanphoun and Shi-Ke Huang are grateful to the National Natural Science Foundation of China (No. 31760014) and the Science and Technology Foundation of Guizhou Province (No. [2017]5788). Monika C. Dayarathne thanks to Thailand Research Fund (TRF) Grant No MRG6080089 for financial research support. Napalai Chaiwan thanks The Royal Golden Jubilee Ph. D. Program (PHD60K0147) under Thailand Research Fund, for financial research supports on project entitle ‘‘Fungi on limestone outcrops from southern Thailand to lower himalyas’’. Saranyaphat Boonmee and Sirinapa Konta would like to thank the National Research Council of Thailand (Grant No. 61215320023, 61215320013) and the Thailand Research Fund (Grant No. TRG6180001) for research financial support. Saisamorn Lumyong would like to thank the Thailand Research Fund (RTA 5880006) and Chiang Mai University for partially support this research work. Itthyakorn Promputtha would like to thank Chiang Mai University for partially supported this research work. Lei Cai acknowledges China-Thailand Joint Lab on Microbial Biotechnology (Most KY201701011) for financial support. PhD students from Mae Fah Laung and Chiang Mai Universities thank the Mushroom Research Foundation for research financial support and PhD Fellowships.

Hydrogen oxidation reaction (HOR) can be applied to proton exchange membrane fuel cells to generate electrical energy and anode discharge. Due to its special properties, RuO2 has been applied to supercapacitors, phenolic wastewater, textile industry wastewater, and degrading organic substances. However, there is few reports on the application of the RuO2 catalyst to hydrogen oxidation reaction (HOR). In this study, we successfully obtained RuO2 NPs using a simple and eco-friendly hydrothermal method. Furthermore, the electrochemical activity of RuO2 NPs prepared at different concentration (0.15 M, 0.20 M) and different hydrothermal temperature (150 °C, 160 °C, and 170 °C) was evaluated by the hydrogen oxidation reaction. The particle size, composition, dispersion and morphology of the obtained RuO2 catalysts were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). In addition, cyclic voltammograms (CV) were utilized to investigate the electrochemical activity of the RuO2 catalysts. The results showed that the obtained catalyst at a hydrothermal temperature of 160 °C and a concentration of 0.15 M displayed a Brunauer-Emmett-Teller (BET) surface area of 26.74 m2 g−1. Meanwhile, the catalyst had a uniform distribution. The hydrogen oxidation current density of the obtained RuO2 catalysts is upto 6 mA cm−2, showing a good electrochemical activity for hydrogen oxidation reaction.

In this article, I present two short, critical responses to two site-specific mountain performances: Xu Zhen’s 8848 Minus 1.86 and ten artists’ To Add One Metre to an Anonymous Mountain. By introdu...