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The article deals with the experience of organizing project and research activities of learners by means of the online learning module in the context of distance learning in the alternative educational organization International Child Center “Artek”. The peculiarities of work of learners using the project and research map “Navigator of Senses” in a distance format are considered. The article describes the essence and structure of the project and research map “Navigator of senses”. Представлен опыт организации проектно-исследовательской деятельности обучающихся посредством сетевого образовательного модуля в условиях дистанционного обучения в нетиповой образовательной организации «Международный детский центр “Артек”». Раскрыты особенности работы обучающихся в дистанционном формате с использованием проектно-исследовательской карты «Навигатор смыслов». Описаны сущность и структура проектно-исследовательской карты «Навигатор смыслов».

In our study, we want to emphasize that each particular state and people due to many reasons and conditions, one of which is the geographical location, is forced to solve its own number of tasks related to ensuring both national and spiritual security. Significant differences between peoples and states in their economic, technological and military power in the population leads to the fact that somehow some nations and states in the historical arena as a force able and willing to impose their will, culture and language of other peoples and States, and others, respectively, as a party, which must in one way or another to perceive the influence and pressure coming from the strong and the many States and peoples. In this case, we are talking about economic and military pressure. However, no less it can relate to cultural and spiritual influence, pressure.

© 2016, Springer Science+Business Media New York.The dispersing action of the surfactant (sodium dodecyl sulfate, SDS) on the carbon nanotubes (CNT) in aqueous medium has been studied. Electron microscopy, molecular docking, NMR and IR spectroscopies were applied to determine the physical-chemical properties of CNT dispersions in SDS—water solutions. It was established that micellar adsorption of the surfactant on the surface of carbon material and solubilization of SDS in aqueous medium contribute to improving CNT dispersing in water solutions. It was shown that the non-polar hydrocarbon radicals of a single surfactant molecule form the highest possible number of contacts with the graphene surface. Upon increase of the SDS in solution these radicals form micelles connected with the surface of the nanotubes. At the sufficiently high SDS concentration the nanotube surface becomes covered with an adsorbed layer of surfactant micelles. Water molecules and sodium cations are concentrated in spaces between micelles. The observed pattern of micellar adsorption is somewhat similar to a loose bilayer of surfactant molecules.

The authors propose to optimize inventory levels in stock companies without using the hypothesis of functional forms of probability density functions and time in explicit form.

Most of the fundamental studies in the field of developing new methods for treating liver diseases in regenerative medicine are performed with haematopoietic and mesenchymal stem cells. At the same time more and more importance is gaining need for finding new approaches enabling stimulation of regional stem cell compartment and using regional stem cells which are possibly represented by hepatic stellate cells. But studies aimed at their transplantation are rare. Previously, we have established the possibility of these cells to differentiate into hepatocytes after transplantation to rats with partial hepatectomy. In our present research we studied liver regeneration after transplantation of hepatic stellate cells on partial hepatectomy with 2-acetylaminofluorene damage model in rats. 2-acetylaminofluorene blocks hepatocyte proliferation. Results of study confirmed that hepatic stellate cells have the ability to differentiate into hepatocyte and stimulate it's regeneration without the threat of fibrosis after transplantation in rats with partial hepatectomy and administration of 2-acetylaminofluorene.

Nowadays more and more attention is turned to hepatic stellate cells (HSC) and their role in liver regeneration. Nonetheless there are several methodological questions, for example, methods of HSC isolation, their labeling and ways of transplantation. In this work we compared two different methods of HSC isolation: collagenase-pronase liver perfusion with further Histodenz density gradient centrifugation and method of Seglen for isolation of hepatocytes associated with HSC. We also analyzed diverse methods of cells labeling: membrane fluorescent labels PKH26 and with gene of green fluorescent protein (GFP), that could be get into the cells by electroporation, with chemicals like TurboFect or by adenovirus. Then cells were transplanted into rats in two ways: into lien and into system of portal vein. According to our results, we able to conclude that collagenase-pronase liver perfusion with further cells gradient centrifugation in Histodenz is better for HSC isolation than method of Seglen, the most optimal method for cells labeling is with adenovirus, expressing the GFP gene, for HSC transplantation - Transplantation into system of portal vein. © Human stem cells institute, 2013.

One of the most common markers of pancreas stem cells is a stem cell factor receptor C-kit. According to some authors, this marker is presented in islet cells of normal rat pancreas. But it is unknown about the behavior of these cells in disorders of carbohydrate metabolism during liver disease. The aim of our study was to evaluate C-kit expression in pancreas after partial hepatectomy in rats. Partial hepatectomy was performed for 27 white male rats. The expression of C-kit, insulin and glucagon in rats pancreas was studied. The expression of C-kit in islets and interstitial cells was shown in results after 3 days of the experiment, and double staining showed that these cells can express glucagon. Thus, there is the activation of C-kit+ progenitor cells in pancreas after partial hepatectomy and the beginning of there differentiation to α-cells of Langerhance islets.