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配架番号：2764, (主査) 教授 髙橋 誠, 教授 近藤 英司, 准教授 高畑 雅彦, 医学院（医学専攻）

Additional file 4: Table S4. Risk factor associated disease progression in COVID-19 patients in univariate Cox regression analysis.

Additional file 5: Table S5. Collinearity diagnosticsof variables in multivariate analysis.

Additional file 1: Table S1. Upper and lower limits of kidney function laboratory parameters in male and female patients with COVID-19.

Additional file 6: Table S6.Associations of kidney function indexes with disease progression in COVID-19 patients by multivariate cox regression analyses.

Additional file 2: Table S2. Risk factors associated with disease progression in COVID-19 patients in univariate Cox regression analysis.

Additional file 3: Table S3. Summary and comparison of recent studies on kidney damage from COVID-19 patients.

People spend a lot of time indoors and the indoor microbiome is a major part of the environment that we are exposed to. However, awareness of the exposure to the indoor microbiome and its health effects remains poor. Outdoor environment (soil and air), indoor sources (ventilation, dampness and building materials), human occupants, and pets compose the indoor microbial community. It has been estimated that up to 500-1000 different species can be present in house dust. House dust is a major source and reservoir of indoor microbiome, which influences human microbiome and determines health and disease. Herein, we review the origins and the components of the fungal and bacterial communities in house dust and their possible effect on human health, in particular on allergic disorders, intestinal microbiome, and immune responses. We expect to lay a solid foundation for the further study on the mechanisms of how the house dust microbes interact with the host microbiome and the human immune system.