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28 results on '"Sferrazza, C."'

1. Oral pathology in untreated coeliac disease

Author

Campisi, G., DI LIBERTO, C., Iacono, G., Compilato, D., DI PRIMA, L., Calvino, F., DI MARCO, V., LO MUZIO, L., Sferrazza, C., Scalici, C., Craxi, A., Carroccio, A., Campisi, G., DI LIBERTO, C., Iacono, G., Compilato, D., DI PRIMA, L., Calvino, F., DI MARCO, V., LO MUZIO, L., Sferrazza, C., Scalici, C., Craxi, A., and Carroccio, A.

Subjects
Settore MED/09 - Medicina Interna, Oral pathology, untreated coeliac disease
Published
2007

3. Validita’ clinica dei marker ossei

Author

Di Fede, G, Carmina, E, Di Rosa, S, Puleo, A, Amari, P, Sferrazza, C, Rini, GB, RIZZO, Manfredi, Di Fede, G, Rizzo, M, Carmina, E, Di Rosa, S, Puleo, A, Amari, P, Sferrazza, C, and Rini, GB

Subjects
L'osso, markers, terapia
Published
2003

4. La vitamina D in pazienti adulti affetti da talassemia major

Author

Di Fede, G, Sferrazza, C, Bucchieri, S, Di Rosa, S, Amari, P, Malizia, R, Bruno, D, Rini, GB, RIZZO, Manfredi, Di Fede, G, Sferrazza, C, Bucchieri, S, Di Rosa, S, Amari, P, Malizia, R, Bruno, D, Rizzo, M, and Rini, GB

Subjects
La vitamina D, talassemia major
Published
2003

5. Su un caso sospetto di schistosomiasi

Author

RIZZO, Manfredi, Di Fede, G, Affronti, M, Di Rosa, S, Sferrazza, C, Amari, P, MANSUETO, Pasquale, Rini, GB, Rizzo, M, Di Fede, G, Affronti, M, Di Rosa, S, Sferrazza, C, Amari, P, Mansueto, P, and Rini, GB

Subjects
schistosomiasi, diagnosi
Published
2003

7. The malnutrition in the elderly: A clinical approach

Author

Pandolfo, M. C., Rizzo, M., Carmina, E., Castello, F., Mansueto, P., Renda, G., Avila, D., Salvatore Bucchieri, Cannone, V., Sferrazza, C., Di Fede, G., Rini, G. B., PANDOLFO, MC, RIZZO, M, CARMINA, E, CASTELLO, F, MANSUETO, P, RENDA, G, AVILA, D, BUCCHIERI, S, CANNONE, V, SFERRAZZA, C, DI FEDE, G, and RINI, GB

Subjects
Settore MED/09 - Medicina Interna, malnutrition, elderly

8. An update on rickettsiosis

Author

Manfredi RIZZO, Mansueto, P., Affronti, M., Sferrazza, C., Bucchieri, S., Napoli, N., Cusumano, G., Cannone, V., Catello, F., Rini, G. B., and Di Fede, G.

11. FokI Polymorphism of the Vitamin D Receptor Gene Correlates with Parameters of Bone Mass and Turnover in a Female Population of the Italian Island of Lampedusa

Author

Gaspare Cusumano, Chiara Cepollaro, M. C. Pandolfo, Nicola Napoli, Alessia Gozzini, M. L. Brandi, F. Del Monte, Giovam Battista Rini, Laura Masi, Valentina Cannone, G. Di Fede, Annalisa Tanini, C. Sferrazza, Alberto Falchetti, FALCHETTI A, SFERRAZZA C, CEPOLLARO C, GOZZINI A, DEL MONTE F, MASI L, NAPOLI N, DI FEDE G, CANNONE V, CUSUMANO G, PANDOLFO MC, RINI GB, TANINI A, and BRANDI ML

Subjects
medicine.medical_specialty, Genotype, Bone density, Endocrinology, Diabetes and Metabolism, Osteoporosis, Calcitriol receptor, Bone and Bones, White People, Cohort Studies, FokI polymorphism of the vitamin D, Endocrinology, Gene Frequency, Bone Density, Risk Factors, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Allele frequency, Osteoporosis, Postmenopausal, Ultrasonography, Polymorphism, Genetic, biology, Exons, Middle Aged, medicine.disease, FokI, Postmenopause, Italy, Premenopause, Osteocalcin, biology.protein, Receptors, Calcitriol, Female, Gene polymorphism
Abstract

One of the most promising genetic approaches to dissecting a multifactorial disease is represented by genetically isolated population studies. We studied a genetic marker in a cohort of women living on the Mediterranean island of Lampedusa, a geographically isolated population. Lampedusa, located between the African coast and Sicily, consists of a young genetic isolate (

Published
2006

12. Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

Author

G. Di Fede, Salvatore Bucchieri, C. Sferrazza, Enrico Carmina, Giovam Battista Rini, Nicola Napoli, NAPOLI N, CARMINA E, BUCCHIERI S, SFERRAZZA C, RINI GB, and DI FEDE G

Subjects
Adult, Male, Vitamin, medicine.medical_specialty, Histology, Bone density, Physiology, Endocrinology, Diabetes and Metabolism, Thalassemia, vitamin D deficiency, Transaminase, Bone remodeling, chemistry.chemical_compound, Bone Density, Internal medicine, Vitamin D and neurology, Humans, Medicine, Vitamin D, Thalassemia major, business.industry, Middle Aged, medicine.disease, Urinary calcium, Endocrinology, chemistry, Parathyroid Hormone, Female, business
Abstract

Adult thalassemic patients have reduced bone mass due to disturbances in several different mechanisms affecting bone turnover. To determine if vitamin D deficiency contributes to the low bone mass of adult thalassemic subjects, we studied serum 25-OH-vitamin D levels in 90 patients (age ranging between 21 and 48 years) affected with thalassemia major (TM) and 35 (age 21-56 years) with thalassemia intermedia (TI). TM patients had been receiving regular transfusions from the age of 2 years and had increased serum ferritin, glutamic oxalacetic transaminase, glutamic piruvic transaminase as well as low bone density (L1-L4 Z score -2.07 +/- 0.2). TI patients did not receive transfusions, but their ferritin levels were increased as well (520.3 +/- 138,1). 8 TM patients (10.1%) and 4 TI (11.4%) had serum 25-OH-vitamin D less than 10.4 ng/ml and were considered presenting an absolute deficiency of vitamin D. Mean 25-OH-vitamin D was significantly (P < 0.01) lower in both TM and TI patients (20.3 +/- 0.7 ng/ml and 20.9 +/- 2.3 ng/ml, respectively) than in 100 healthy control subjects of similar age (25.2 +/- 1 ng/ml). 1,25-OH-vitamin D levels were in the normal-lower levels (45.15 +/- 1.5 mg/dl), while 24 H urinary calcium was below the normal range (15.75 mg/dl). In TM patients, the 25-OH-vitamin D levels correlated negatively with age (P < 0.05) and with serum ferritin (P < 0.05). TM and TI patients with low 25-OH-vitamin D levels (

Published
2006

13. MMP-2, MMP-9 and activin A blood levels in patients with breast cancer or prostate cancer metastatic to the bone

Author

INCORVAIA, Lorena, BADALAMENTI, Giuseppe, RINI, Giovam Battista, ARCARA, Carmelo Carlo, SFERRAZZA, Carmela, GEBBIA, Nicolo', LETO, Gaetano, DI TRAPANI D, Fricano, S., Di Trapani, D., INCORVAIA L, BADALAMENTI G, RINI GB, ARCARA C, FRICANO S, SFERRAZZA C, GEBBIA N, and LETO G

Subjects
Adult, Aged, 80 and over, Male, Mucin-1, Prostatic Neoplasms, Bone Neoplasms, Breast Neoplasms, Middle Aged, Activins, Activin, Breast Cancer, Bone metastasis, proteinases, Matrix Metalloproteinase 9, Aged, Female, Humans, Matrix Metalloproteinase 2
Abstract

Background: The clinical significance of the circulating levels of activin A and matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) was investigated in patients with breast cancer (BC) or prostate cancer (PC) with (M1) or without (M0) bone metastasis. Patients and Methods: MMP-2, MMP-9 and activin A blood concentrations were measured by enzyme immunoassays in 79 cancer patients and in 57 healthy blood donors (HS) who served as a control group. The diagnostic accuracy of these molecules to discriminate between M0 and M1 patients was evaluated by the receiver operating characteristic curve (ROC) and compared to that of tumor markers CA15.3 or prostate-specific antigen (PSA). Results: Activin A and MMP-2 were significantly increased in BC and PC patients as compared to sex-matched HS while MMP-9 levels were more elevated only in the PC patients. Interestingly, in the PC patients, activin A levels were significantly higher than those measured in the BC patients. In this latter group, activin A and CA15.3 but not MMP-2 or MMP-9 were increased in the M1 patients as compared to M0 patients. Furthermore, a significant relationship was also highlighted between activin A concentration and the number of bone metastases and tumor grade, between MMP-9 and tumor grade, and between MMP-2 and CA15.3. ROC curve analysis showed a good diagnostic accuracy for activin A and CA15.3 but a poor accuracy for MMP-2 and MMP-9 in discriminating between M0 and M1 patients. However, CA15.3 retained the best diagnostic accuracy in this respect. In the PC group, only activin A and PSA levels were significantly increased in the M1 patients as compared to the M0 patients. A similar although not statistically significant trend was noted for MMP-9. Interestingly, a significant correlation was observed between PSA and activin A and MMP-9, and between Activin A and Gleason score and the number of skeletal metastases. ROC curve analysis showed a good diagnostic accuracy for activin A, MMP-9 and PSA and a poor diagnostic accuracy for MMP-2 in detecting M1 patients. However, PSA showed the highest diagnostic accuracy. Conclusion: Activin A, MMP-2 and MMP-9 may be regarded as possible therapeutic targets in the treatment of metastatic bone disease. However, their usefulness as additional markers of bone metastasis remains to be better defined

Published
2007

21. Cognitive Impairment and Osteoporosis in persons 50+ years old: a population-based study

Author

CAMARDA, Lawrence, BAIAMONTE V, CAMARDA, Cecilia, CAMMALLERI R, FARINELLA G, MONASTERO R, PIPIA, Carmela, SPATARO, Rossella, DI FEDE G, MAGGIO, Claudia, SFERRAZZA, Carmela, RINI, Giovam Battista, CAMARDA, Rosolino, CAMARDA LK, BAIAMONTE V, CAMARDA C, CAMMALLERI R, FARINELLA G, MONASTERO R, PIPIA C, SPATARO R, DI FEDE G, MAGGIO C, SFERRAZZA C, RINI G, and CAMARDA R

Published
2004

22. Correlation between deficiency of 25 (OH) vitamin D, bone mineral density and markers of bone turnover in sicialian postmenopausal womens

Author

SFERRAZZA, Carmela, CARMINA, Enrico, AVILA, Daniela, DI LORENZO, Gabriele, VITALE G, SUTERA L, BUCCHIERI, Salvatore, CUSUMANO, Gaspare, PANDOLFO, Maria Concetta, NAPOLI, Nicola, RINI, Giovam Battista, DI FEDE, Gaetana, SFERRAZZA C, CARMINA E, AVILA D, DI LORENZO G, VITALE G, SUTERA L, BUCCHIERI S, CUSUMANO G, PANDOLFO MC, NAPOLI N, RINI GB, and DI FEDE G

Published
2004

24. Correlation between deficiency of 25 (OH) vitamin D and liver damage in adult talassemic subjects

Author

SFERRAZZA, Carmela, CARMINA, Enrico, CANNONE, Valentina, CASTELLO, Francesco, DI LORENZO, Gabriele, CUSUMANO, Gaspare, PANDOLFO, Maria Concetta, BRUNO, Dario, RINI, Giovam Battista, DI FEDE, Gaetana, AVILA, Daniela, RENDA G, SUTERA L, SFERRAZZA C, CARMINA E, CANNONE V, CASTELLO F, DI LORENZO G, RENDA G, SUTERA L, CUSUMANO G, PANDOLFO MC, BRUNO D, RINI GB, DI FEDE G, and Avila, D.

Published
2004

25. Il polimorfismo C4887A del gene CYP1A1 influenza il metabolismo estrogenico e la massa ossea

Author

Napoli, N., RINI G, B., GULLOTTI, Dino Filippo, MANSUETO, Pasquale, CANNONE, Valentina, SFERRAZZA, Carmela, SFERRAZZA, Stefania, SUTERA, Loredana, BRUNO, Dario, DI FEDE, Gaetana, Napoli, N., Gullotti, D., Mansueto, P., Cannone, V., Sferrazza, C., Sferrazza, S., Sutera, L., Bruno, D., RINI G, B., and DI FEDE, G.

Subjects
polimorfismo C4887A, gene CYP1A1, Settore MED/09 - Medicina Interna, massa ossea
Published
2004

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