710 results on '"Settimi A"'
Search Results
2. Gestione delle recidive di poliposi nasale dopo chirurgia nell’era dei biologici: review narrativa
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Eugenio De Corso, Stefano Settimi, Claudio Montuori, Alessandro Cantiani, Marco Corbò, Giuseppe Alberto Di Bella, Fabio Sovardi, Fabio Pagella, Mario Rigante, Giulio Cesare Passali, Gaetano Paludetti, and Jacopo Galli
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General Energy ,Otorhinolaryngology - Published
- 2023
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3. Asymptotic formulation of the nonlinear bifurcation scenarios in thermomechanically coupled plates
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Valeria Settimi and Giuseppe Rega
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Control and Systems Engineering ,Applied Mathematics ,Mechanical Engineering ,Aerospace Engineering ,Ocean Engineering ,Electrical and Electronic Engineering - Published
- 2023
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4. Practical recommendations for managing severe chronic rhinosinusitis with nasal polyps in the era of biologics
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De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Trimarchi, Matteo, Torretta, Sara, Cavaliere, Carlo, Lucidi, Daniela, Seccia, Veronica, Settimi, Stefano, Canevari, Frank Rikki Mauritz, Pasquini, Ernesto, La Mantia, Ignazio, Garzaro, Massimiliano, Bellocchi, Gianluca, De Benedetto, Michele, Lombardo, Nicola, Macchi, Alberto, Malvezzi, Luca, Motta, Gaetano, Vicini, Claudio, Maselli, Alessandro, Dell'Era, Valeria, Dragonetti, Alberto, Asprea, Francesco, Lupato, Valentina, Ghidini, Angelo, Masieri, Simonetta, Mattavelli, Davide, Salzano, Francesco Antonio, Passali, Desiderio, Galli, Jacopo, Pagella, Fabio, De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Trimarchi, Matteo, Torretta, Sara, Cavaliere, Carlo, Lucidi, Daniela, Seccia, Veronica, Settimi, Stefano, Canevari, Frank Rikki Mauritz, Pasquini, Ernesto, La Mantia, Ignazio, Garzaro, Massimiliano, Bellocchi, Gianluca, De Benedetto, Michele, Lombardo, Nicola, Macchi, Alberto, Malvezzi, Luca, Motta, Gaetano, Vicini, Claudio, Maselli, Alessandro, Dell'Era, Valeria, Dragonetti, Alberto, Asprea, Francesco, Lupato, Valentina, Ghidini, Angelo, Masieri, Simonetta, Mattavelli, Davide, Salzano, Francesco Antonio, Passali, Desiderio, Galli, Jacopo, and Pagella, Fabio
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chronic rhinosinusiti ,Type 2 inflammation ,practical recommendation ,biologic ,nasal polyp - Abstract
Objective: We conducted a national survey to understand how rhinology practice has changed with the advent of biologics and how this affected patients with uncontrolled, severe chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to analyse the results of the survey and infer practical recommendations for clinical practice. Methods: A group of ear, nose, and throat specialists (ENTs) experienced in the management of CRSwNP developed a 74-question survey. ENTs from rhinology centres authorised to prescribe biologics in the context of the national health system were invited to answer it between 01/05/2022 and 31/07/2022. The responses underwent descriptive analyses, and the authors discussed the results and derived practical recommendations for clinical practice. Results: ENTs working in rhinology centres changed their practices coinciding with the advent of biologics. CRSwNP evaluations have become more complex because they involve diagnostic confirmation, determining the patients' immunologic profile, and other factors. We observed heterogenous behaviours in practice that may be conditioned by the novelty of the topic. The results of the survey were used to develop practical recommendations for ENTs and are summarised herein. Conclusions: Clinical practice in rhinology outpatient clinics has changed profoundly in the era of biologics. Our practical recommendations for clinicians working in rhinology centres are expected to help standardise practice and improve care.
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- 2023
5. Avaliação Psicológica no Estado do Maranhão: Cenário Atual e Direções Futuras
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Sá, Lucas Guimarães Cardoso de, Bastos, Larissa Fook, Oliveira, Anis Settimi de, and Duarte, Laura Andrelynne Durans
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psychometrics ,Psychologists ,medición ,avaliação psicológica ,pruebas psicológicas ,psychological assessment ,evaluación psicológica ,testes psicológicos ,psicometría ,psychological testing ,psicólogos ,psicometria ,measurement ,mensuração - Abstract
Resumo As últimas duas décadas trouxeram mudanças para o campo da Avaliação Psicológica (AP) no Brasil. Considerando que historicamente o desenvolvimento da Psicologia foi desigual entre as regiões do país, este estudo teve como objetivo investigar as práticas, a formação e o conhecimento de psicólogos maranhenses sobre avaliação psicológica. Participaram 124 psicólogos com registro ativo no Conselho Regional de Psicologia do Maranhão, que responderam a um roteiro estruturado de entrevista elaborado para este estudo. Os resultados mostraram que a maioria afirma realizar AP na sua prática profissional, que entrevista é a técnica mais usada e considerada mais importante para o processo, que há indícios de avanço na formação em AP no estado do Maranhão, mas que permanecem dificuldades em relação à compreensão de conceitos psicométricos e na inserção das práticas de AP no dia a dia do trabalho dos psicólogos. Abstract The field of Psychological Assessment (PA) in Brazil faced changes in the last two decades. Since the development of Psychology has been historically uneven between the regions of the country, this study aimed to assess the practices, academic training, and knowledge of psychologists from the state of Maranhão on psychological assessment. 124 psychologists with active registration in the Regional Council of Psychology of Maranhão participated responding to a structured interview script prepared for this study. The results show that most claim to perform PA in their professional practice; that interview is the most used technique and it is considered the most important for the process; that there are indications of progress in PA training in the state of Maranhão, but some difficulties remain regarding the comprehension of psychometric concepts and the insertion of PA practices in the daily work of psychologists. Resumen Las ultimas dos décadas trajeron cambios para el campo de la Evaluación Psicológica (EP) en Brasil. Considerando que históricamente el desarrollo de la Psicología fue desigual entre las regiones del país, este estudio tuvo como objetivo investigar las prácticas, la formación y el conocimiento de psicólogos del estado de Maranhão sobre evaluación psicológica. Participaron 124 psicólogos con matrícula activa en el Consejo Regional de Psicología de Maranhão, que respondieron a un guión estructurado de entrevista elaborado para este estudio. Los resultados mostraron que: la mayoría afirma realizar EP en su práctica professional; la entrevista es la técnica mas usada y considerada mas importante para el processo; hay indicios de avances en la formación en EP en el estado de Maranhão, pero permanecen dificultades en relación a la comprensión de conceptos psicométricos y en la inserción de las prácticas de EP en el día a día del trabajo de los psicólogos.
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- 2023
6. Safe and Robust Map Updating for Long-Term Operations in Dynamic Environments
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Pallottino, Elisa Stefanini, Enrico Ciancolini, Alessandro Settimi, and Lucia
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mapping ,localisation ,dynamic environments - Abstract
Ensuring safe and continuous autonomous navigation in long-term mobile robot applications is still challenging. To ensure a reliable representation of the current environment without the need for periodic remapping, updating the map is recommended. However, in the case of incorrect robot pose estimation, updating the map can lead to errors that prevent the robot’s localisation and jeopardise map accuracy. In this paper, we propose a safe Lidar-based occupancy grid map-updating algorithm for dynamic environments, taking into account uncertainties in the estimation of the robot’s pose. The proposed approach allows for robust long-term operations, as it can recover the robot’s pose, even when it gets lost, to continue the map update process, providing a coherent map. Moreover, the approach is also robust to temporary changes in the map due to the presence of dynamic obstacles such as humans and other robots. Results highlighting map quality, localisation performance, and pose recovery, both in simulation and experiments, are reported.
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- 2023
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7. Calprotectin in nasal secretion: a new biomarker of non-type 2 inflammation in CRSwNP
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Eugenio De Corso, Silvia Baroni, Maria Elisabetta Onori, Laura Tricarico, Stefano Settimi, Giacomo Moretti, Eliana Troiani, Rodolfo Francesco Mastrapasqua, Daniela Furno, Fabrizio Crudo, Andrea Urbani, and Jacopo Galli
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Inflammation ,precision medicine ,Nasal Polyps ,General Energy ,immunophenotyping ,Otorhinolaryngology ,Chronic Disease ,Humans ,Settore MED/31 - OTORINOLARINGOIATRIA ,Sinusitis ,nasal polyps ,rhinitis ,sinusitis ,Leukocyte L1 Antigen Complex ,Biomarkers ,Rhinitis - Abstract
We analysed calprotectin in sinonasal secretions of different chronic rhinosinusitis with nasal polyps (CRSwNP) endotypes to assess its role as a biomarker of non-type 2 inflammation.We included primary diffuse CRSwNP patients (n = 41) and three different control groups [non-allergic rhinitis (NAR) (n = 13), non-allergic eosinophilic syndrome (NARES) (n = 10) and healthy subjects (n = 12)]. Calprotectin levels were detected in nasal secretions using a chemiluminescent immunoassay (CLIA).Calprotectin levels in nasal secretions were significantly higher in all non-type 2 endotypes of CRSwNP compared to healthy controls (p0.05). In contrast, in type-2 CRSwNP calprotectin was significantly lower compared to controls (p0.05). A significant correlation between calprotectin levels and neutrophilic count/HPF was found in CRSwNP (p0.01). Clinically, mean levels of calprotectin and neutrophilia were significantly higher in patients who previously underwent 3 or more endoscopic sinus surgeries (p0.05).Calprotectin in nasal secretions may be a biomarker of non-type 2 inflammation. Low levels of calprotectin are indicative of a type-2 immune response in both CRSwNP and non-allergic rhinitis. We observed that calprotectin levels significantly increased based on the number of previous surgeries.Calprotectina nel secreto nasale: nuovo biomarker di infiammazione non-tipo 2 nella poliposi nasale.Abbiamo analizzato i livelli di calprotectina nelle secrezioni nasali di diversi endotipi di CRSwNP, per valutarne il ruolo di marcatore di infiammazione non-tipo 2.Abbiamo incluso pazienti con CRSwNP diffusa primaria (n = 41) e tre diversi gruppi di controllo [rinite non allergica (NAR) (n = 13), rinite eosinofila non allergica (NARES) (n = 10) e soggetti sani (n = 12)]. I livelli di calprotectina sono stati dosati mediante test di chemoluminescenza.I livelli di calprotectina sono risultati significativamente più alti in tutti gli endotipi non-tipo 2 di CRSwNP, rispetto ai controlli sani (p0,05). Al contrario, nella CRSwNP tipo 2 essa è risultata inferiore rispetto ai controlli (p0,05). È stata riscontrata una correlazione significativa tra i livelli di calprotectina e la conta dei neutrofili/HPF (p0.01). I livelli medi di calprotectina aumentano inoltre nei pazienti in precedenza sottoposti a 3 o più ESS (p0,05).La calprotectina nelle secrezioni nasali può essere considerata un biomarcatore di infiammazione non-tipo 2 mentre bassi livelli di calprotectina sono indicativi di immunoflogosi di tipo 2. Abbiamo infine osservato che i livelli di calprotectina aumentano significativamente in relazione al numero di interventi chirurgici pregressi.
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- 2022
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8. Magnetic field interactions between current consumer electronics and cardiac implantable electronic devices
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Kathryn Xu, Jay Sengupta, Susan Casey, Joel Peltier, Wyatt Stahl, Neal Peterson, David Settimi, Andrew Taylor, James Kippola, Elizabeth Steele, and Robert Hauser
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Pacemaker, Artificial ,Electromagnetic Fields ,Magnetic Fields ,Physiology (medical) ,Humans ,Electronics ,Cardiology and Cardiovascular Medicine ,Defibrillators, Implantable - Abstract
Electronic products, including the iPhone 12, Apple Watch Series 6, and 2nd Generation AirPods, contain magnets to facilitate wireless charging. Permanent magnets may affect CIED magnet mode features by causing pacemakers to pace asynchronously and defibrillators to suspend arrhythmia detection. This study determined if CIEDs are affected by static magnetic fields from commonly used portable electronics (PE) at any distance and intends to reinforce FDA recommendations concerning consumer PE which contain permanent magnets.The maximum magnet field measurement was evaluated by a Gauss meter. The interaction between PE and CIEDs from Boston Scientific and Medtronic were tested ex vivo using a body torso model. The CIED was placed in physiologic saline, and the PE was placed at the surface and at increasing distances of 0.5, 1.0, and 1.5 cm. Interactions were recorded by assessment of magnet mode status.The iPhone 12 had almost three times the static magnetic field measured at the surface as the iPhone XR, but magnetic field strength decreased dramatically with increasing distance. At the surface of the model, PE triggered magnet mode in all CIEDs. The maximum interaction distance for all combinations of CIEDs and Apple products was 1.5 cm.The iPhone 12 produces a stronger static magnetic field than previous iPhone models. Magnets in PE tested will not interact with CIEDs when they are 15 cm from the implanted device. Since no interaction was observed beyond 1.5 cm, it is unlikely that magnet mode activation will occur during most daily activities.
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- 2022
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9. Safe_and_Robust_Map_Updating_For_Long-Term_Operations_in_Dynamic_Environments
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Elisa Stefanini, Enrico Ciancolini, Alessandro Settimi, and Lucia Pallottino
- Abstract
Ensuring safe and continuous autonomous navigation in long-term mobile robot applications is still challenging. To ensure a reliable representation of the current environment without the need for periodic re-mapping, updating the map is recommended. However, in case of incorrect estimation of robot pose, updating the map can lead to errors that prevent the robot localisation and jeopardize map accuracy. In this paper, we propose a safe LIDAR-based occupancy grid map updating algorithm for dynamic environments taking into account the uncertainties in the estimation of the robot’s pose. The proposed approach allows robust long-term operations as it can recover the robot’s pose, even when it gets lost, to continue the map update process providing a coherent map. Moreover, the approach is robust also to temporary changes in the map due to the presence of dynamic obstacles such as humans and other robots. Results highlighting map quality, localisation performance, and pose recovery, both in simulation and experiments, are reported.
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- 2023
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10. Hypocapnia as a predictor of the need for non-invasive mechanical ventilation in subjects with SARS-CoV-2 related pneumonia
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Stefano De Vuono, Sokol Berisha, Laura Settimi, Pasquale Cianci, Alessandra Lignani, Gianmarco Lanci, Maria Rita Taliani, and Paolo Groff
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General Medicine - Abstract
Background: SARS-CoV-2 related pneumonia is characterized by moderate-to severe hypoxemia often associated with hypocapnia the prognostic role of which is poorely documented. Aims: evaluate if hypocapnia can predict the need for non-invasive mechanical ventilation (NIMV) in this setting. Materials and methods: we prospectively studied 52 subjects with moderate-severe SARS-CoV-2 related pneumonia. All the following data were collected at admission to the Emergency Department and processed by univariate and multivariate analysis: clinical and laboratory data, blood gas analysis in room air and lung ultrasound. Results: 33/52 subjects (63,4%) underwent NIMV. At univariate analysis PaCO2 was inversely associated to the need for NIMV (OR 0,82, CI 95% 0,689-0,976, p .025). At multivariate analysis PaCO2 predicted the need for NIMV independently from age, gender, number of comorbidities, d-dimer, CRP, PaO2 and LUS SCORE (OR 0,838, CI 95% 0,710-0,988, p .035). Conclusions: our data suggest that hypocapnia could be an early predictor of clinical worsening in these patients independently from other known predictors of unfavourable outcome, reflecting the occurrence of a deep and frequent respiratory pattern possibly related to the generation of excessive transpulmonary pressure swings leading to a self-induced lung injury (P-SILI). Further studies are needed for validating these data on greater populations.
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- 2023
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11. Twenty-Five-Year Experience with Minimally Invasive Splenectomy in Children: From Minilaparotomy to Use of Sealing Devices and Indocyanine Green Fluorescence Technology: Tips and Tricks and Technical Considerations
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Ciro Esposito, Ugo De Luca, Mariapina Cerulo, Fulvia Del Conte, Vincenzo Bagnara, Sandra Coppola, Francesco Corcione, Benedetta Lepore, Alessandro Settimi, Maria Escolino, Esposito, Ciro, De Luca, Ugo, Cerulo, Mariapina, Del Conte, Fulvia, Bagnara, Vincenzo, Coppola, Sandra, Corcione, Francesco, Lepore, Benedetta, Settimi, Alessandro, and Escolino, Maria
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ICG ,Indocyanine Green ,Laparotomy ,Adolescent ,children ,Retrospective Studie ,Splenectomy ,sealing device ,Humans ,Surgery ,Laparoscopy ,Child ,Human ,Retrospective Studies - Abstract
Background: This study aimed to review our 25-year experience with pediatric laparoscopic splenectomy (LS) and describe tips, tricks, and technical considerations. Methods: The records of 121 children, undergoing minimally invasive splenectomy in the last 25 years (1996-2021), were retrospectively reviewed. Median patient age was 10.2 years (range 7-17). The patients were grouped according to the period: G1 (1996-2005) included 31 patients undergoing open splenectomy using left subcostal minilaparotomy (G1a) and 28 receiving LS using supine position (G1b); G2 (2006-2021) included 62 patients undergoing LS using lateral decubitus. A five-trocar technique was adopted in G1b, with the spleen removed through a Pfannenstiel incision. In G2, we preferred to use lateral decubitus, 10-mm 30° optic, only four trocars, and sealing devices. In such cases, the spleen was placed in an endobag, finger-fragmented, and extracted through the umbilicus. Furthermore, indocyanine green (ICG) fluorescence was used in the last 4 G2 patients to clearly identify the vascular anatomy. Results: The median operative time was 65 minutes in G1a, 125 in G1b, and 95 in G2. Complications occurred intraoperatively in 14 cases (11.5%): 5 bleedings during dissection (G1b), 4 endobag breakages during spleen removal (G2); 3 spleen capsule breakages during removal (G1a); and 2 instrumentation failures (G2). No conversions to open occurred. Median hospital stay was 6 days in G1a and 4 days in G1b and G2. Conclusions: LS is a standardized and effective procedure in children and is preferable to mini- or conventional open splenectomy. Our 25-year experience showed that major complications may occur even in expert hands, mainly during hilar dissection or spleen extraction. Technically, sealing devices and ICG fluorescence were helpful to perform a safer and faster procedure. We believe that lateral decubitus and 30° optic should be considered technical key points to provide excellent organ exposure and easier dissection of hilar structures.
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- 2022
12. Correction of Phase Balance on Nd:YAG Pulsed Laser Welded UNS S32750 Using Cobalt Electroplating Technique
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Eli J. Da Cruz Junior, Bruna B. Seloto, Vicente A. Ventrella, Francisco M. F. A. Varasquim, Andrea Zambon, Irene Calliari, Claudio Gennari, and Alessio G. Settimi
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Inorganic Chemistry ,Nd:YAG pulsed laser welding ,super duplex stainless steel ,General Chemical Engineering ,volume fraction ,microstructure ,cobalt electroplating ,microhardness ,super duplex stainless steel, Nd:YAG pulsed laser welding, cobalt electroplating, volume fraction, microstructure, microhardness ,General Materials Science ,Condensed Matter Physics - Abstract
Super-duplex stainless steel (SDSS) shows high mechanical and corrosion resistance because of the balanced structure of austenite and ferrite. However, maintaining this phase ratio after welding is a challenge. The use of austenite stabilizing components is recommended to balance the microstructure. The addition of alloying elements presents a challenge because of the characteristics of Nd:YAG pulsed laser welding. An approach, which has proven to be effective, is to use metal electroplating to prepare the surfaces of the mechanical SDSS components that will be welded, therefore promoting the phase balance in the fusion zone. While the effects of metals such as nickel as an austenite stabilizer are well recognized, cobalt’s effects require more research. The present work investigated the influence of the use of cobalt addition in the joining process by preliminary electroplating on UNS S32750 SDSS Nd: YAG pulsed laser welding, specifically regarding microstructure and microhardness. Three conditions were investigated, changing the thickness of the deposited cobalt layer. The addition of cobalt modified the morphology and increased the volume fraction of austenite. An austenite volume fraction of around 48% was obtained using a 35 μm thick cobalt coating. The microhardness was affected by austenite/ferrite proportions. The microhardness dropped from about 375 HV to 345 HV as the cobalt layer’s thickness rose, being similar to that of the base metal. The effect of cobalt as an austenite stabilizer was observed, and the cobalt electroplating technique was effective to correct the phase balance on UNS S32750 laser welding.
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- 2023
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13. Production and Characterization of Photocatalytic PEO Coatings Containing TiO2 Powders Recovered from Wastes
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Luca Pezzato, Elena Colusso, Pietrogiovanni Cerchier, Alessio Giorgio Settimi, and Katya Brunelli
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aluminum alloys ,plasma electrolytic oxidation ,corrosion ,circular economy ,Materials Chemistry ,titanium oxide ,Surfaces and Interfaces ,photocatalytic ,Surfaces, Coatings and Films - Abstract
In this work, the possibility of incorporating TiO2 titanium dioxide particles derived from the recycling process of photovoltaic panels into PEO coatings was investigated. These particles constitute the main filler of the polymer constituting the rear part of the panels, and are characterized by possessing photocatalytic properties. The particles were added in different quantities to the electrolyte (a basic solution containing sodium silicate). The incorporation into the PEO coating produced on an aluminum alloy 1050, and the possibility of conferring photocatalytic properties to the surface of the samples were studied. The different samples were first characterized by optical microscope analysis, SEM and XRD and from the point of view of corrosion resistance by means of potentiodynamic tests. The photocatalytic properties of the samples were evaluated by monitoring the degradation of aqueous solutions of methylene blue exposed to a UV lamp. The particles have been successfully incorporated into the coating, and their presence does not alter the corrosion properties, which are improved compared to the uncoated sample. The particles, initially composed of a mixture of rutile and anatase, are instead transformed into rutile after incorporation due to the locally very high temperatures that can occur during the PEO process. In the samples obtained with higher quantities of titanium dioxide particles (60 and 80 g/L), a significant photocatalytic effect is observed with a significant reduction of methylene blue.
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- 2023
14. Produzione e caratterizzazione di rivestimenti PEO con proprietà fotocatalitiche contenenti polveri di TiO2da rifiuto
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Pezzato, L., Colusso, E., Cerchier, P., Settimi, A. G., Martucci, A., Dabala, M., and Brunelli, K.
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- 2023
15. Point of care ultrasonography-cardiac arrest: a case report
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Sokol BERISHA, Stefano DE VUONO, Laura SETTIMI, Alessandra LIGNANI, Federica MACELLARI, Rachele DEL SORDO, and Paolo GROFF
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General Medicine - Published
- 2023
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16. ESTUDO HIDROLÓGICO DE UMA BACIA HIDROGRÁFICA: DESCRIÇÃO FISIOGRÁFICA, HIDROGEOLÓGICA, PLUVIOMÉTRICA, TEMPERATURA, UMIDADE E RADIAÇÃO
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Flavio Augusto Settimi Sohler, José Roberto Ribas, and Friedrich Wilhelm Herms
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Objetivo: O objetivo deste capítulo é Realizar um Estudo Hidrológico simplificado de uma bacia hidrográfica. Método: A ideia principal do método é apresentar mapas de localização, área, coeficiente de compacidade, fator de forma, densidade de drenagem, além da caracterização do tipo de solo, rocha, vegetação predominante, curvas IDF, séries históricas de chuva e sua correlação com a temperatura, umidade e radiação. Resultados: Os resultados foram obtidos calculando-se o fator de forma, o coeficiente de compacidade para a bacia hidrográfica e para a microbacia, além do cálculo da densidade de drenagem e comparando-se os resultados da macro bacia com a microbacia. Conclusão: A temperatura aumentou ao longo dos anos, assim como a precipitação e evaporação. A umidade, insolação e velocidade do vento reduziram. Alguns fatores podem auxiliar na identificação das causas destes fenômenos: crescimento da população ao longo dos anos, construção de grandes e altos edifícios em concreto, impermeabilização do solo e maior industrialização, o que sem dúvida, trouxe uma maior poluição dos recursos hídricos em geral.
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- 2023
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17. Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps
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Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Rodolfo Francesco Mastrapasqua, Eliana Troiani, Giacomo Moretti, Donatella Lucchetti, Marco Corbò, Claudio Montuori, Alessandro Cantiani, Davide Paolo Porru, Simone Lo Verde, Giuseppe Alberto Di Bella, Cristiano Caruso, and Jacopo Galli
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chronic rhinosinusitis ,eosinophilic rhinitis ,nasal polyposis ,biomarker ,medical therapy of chronic rhinosinusitis ,disease severity ,Medicine (miscellaneous) ,Settore MED/31 - OTORINOLARINGOIATRIA - Abstract
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load of inflammation and to analyze human interleukins in nasal secretion. Clinical data were collected to evaluate the severity of the disease. High levels of IL-5, IL-4, IL-6, and IL-33 were detected in all type 2 CRSwNP patients. By analyzing type 2 cytokine profiles and local eosinophil count, we identified two coherent clusters: the first was characterized by high levels of IL-4, IL-5, IL-6, and a high-grade eosinophil count (type 2-high); the second had lower levels of cytokines and poor or absent eosinophilic inflammation (type-2 low). IL-5 levels were significantly higher within the type 2 cytokine and it was the most reliable biomarker for differentiating the two clusters. In type 2-high inflammatory profile clinical scores, the mean number of previous surgeries and need for systemic corticosteroids were significantly higher compared to type 2-low. Our research demonstrated the potential role of type 2 biomarkers, and in particular, of IL-5 in identifying patients with a more severe phenotype based on a high inflammatory load.
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- 2023
18. Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps): a multicentric observational phase IV real‐life study (DUPIREAL)
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De Corso Eugenio, Pasquini, Ernesto, Trimarchi, Matteo, La Mantia Ignazio, Pagella, Fabio, Ottaviano, Giancarlo, Garzaro, Massimiliano, Pipolo, Carlotta, Torretta, Sara, Seccia, Veronica, Cantone, Elena, Ciofalo, Andrea, Lucidi, Daniela, Fadda Gian Luca, Pafundi Pia Clara, Settimi, Stefano, Montuori, Claudio, Anastasi, Francesca, Pagliuca, Giulio, Ghidini, Angelo, Cavaliere, Carlo, Maffei, Marianna, Bussu, Francesco, Gallo, Stefania, Canevari Frank Rikki Mauritz, Paludetti, Gaetano, Galli, Jacopo, Spanu, Camilla, Porru Davide Paolo, Lo Verde Simone, Corbò, Marco, Cantiani, Alessandro, Furno, Daniela, D’Agostino, Giuseppe, D’Auria Leandro Maria, De Maio Gabriele, Di Bella Giuseppe Alberto, Penazzi, Daniele, Mele Dario Antonio, Di Cesare Tiziana, Andrea, Rampi, Umberto, Tanzini, Saccardo, Tommaso, Roccuzzo, Giuseppe, Cipolla, Federica, Ragusa, Martina, Grigaliute, Egle, Alicandri Ciufelli Matteo, Roncadi, Leonardo, Rizzo, Davide, De Vita Carla, Farneti, Paolo, Todero, Gabriella, Cristofani‐mencacci, Lodovica, Statuti, Erica, Cavallo, Giovanni, Urbanelli, Anastasia, Ferrella, Francesco, Arnone, Flavio, Di Nola Claudio, Pignataro, Lorenzo, Nava, Nicolò, Russo, Paolo, Savastano, Vincenzo, Masieri, Simonetta, Dell’Era, Valeria, Aluffi Valletti Paolo, Sovardi, Fabio, Siragusa, Vera, Clemenzi, Veronica, Stolfa, Andrea, Simoni, Edi, and Astolfi, Laura
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dupilumab ,smell ,biologics ,dupireal ,crswnp ,asthma, biologics, chronic rhinosinusitis with nasal polyps, dupilumab, smell ,asthma ,chronic rhinosinusitis with nasal polyps - Published
- 2023
19. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. G., Kanamori S., Yamamoto K., Kumagai K., Katsuda Y., Sadamatsu K., Toyota F., Mizuno Y., Misumi I., Noguchi H., Ando S., Suetsugu T., Minamoto M., Oda H., Shiraishi K., Adachi S., Chiba K., Norita H., Tsuruta M., Koyanagi T., Ando H., Higashi T., Okada K., Azakami S., Komaki S., Kumeda K., Murayama T., Matsumura J., Oba Y., Sonoda R., Goto K., Minoda K., Haraguchi Y., Suefuji H., Miyagi H., Kato H., Nakamura T., Nandate H., Zaitsu R., Fujiura Y., Yoshimura A., Numata H., Ogawa J., Tatematsu H., Kamogawa Y., Murakami K., Wakasa Y., Yamasawa M., Maekawa H., Abe S., Kihara H., Tsunoda S., Saito K., Fudo T., Obunai K., Tachibana H., Oba I., Kuwahata T., Higa S., Gushiken M., Eto T., Yoshida H., Ikeda D., Ishizawa M., Nakatsuka M., Murata K., Ogurusu C., Shimoyama M., Akutsu M., Takamura I., Hoshino F., Yokota N., Iwao T., Tsuchida K., Takeuchi M., Hatori Y., Kitami Y., Nakamura Y., Oyama R., Ageta M., Go Y., Mishima K., Unoki T., Morii S., Shiga Y., Sumi H., Nagatomo T., Sanno K., Fujisawa K., Atsuchi Y., Nagoshi T., Seto T., Tabuchi T., Kameko M., Nii K., Oshiro K., Takezawa H., Nagano S., Miyamoto N., Iwaki M., Fujii M., Okawa M., Abe M., Saito T., Mito T., Nagao K., Minami J., Mita T., Sakuma I., Taguchi T., Marusaki S., Doi H., Tanaka M., Fujito T., Matsuta M., Kusumoto T., Kakinoki S., Ashida K., Yoshizawa N., Agata J., Arasaki O., Manita M., Ikemura M., Fukuoka S., Murakami H., Matsukawa S., Hata Y., Taniguchi T., Ko T., Kubo H., Imamaki M., Akiyama M., Inagaki M., Odakura H., Ueda T., Katsube Y., Nakata A., Watanabe H., Techigawara M., Igarashi M., Taga K., Kimura T., Tomimoto S., Shibuya M., Nakano M., Ito K., Seo T., Hiramitsu S., Hosokawa H., Hoshiai M., Hibino M., Miyagawa K., Horie H., Sugishita N., Soma A., Neya K., Yoshida T., Mizuguchi M., Ishiguro M., Minagawa T., Wada M., Mukawa H., Okuda F., Nagasaka S., Abe Y., Adachi T., Akahane K., Amano T., Aoki K., Aoyama T., Arai H., Arima S., Arino T., Asano H., Asano T., Azuma J., Baba T., Betsuyaku T., Chibana H., Date H., Doiuchi J., Emura Y., Endo M., Fujii Y., Fujiki R., Fujisawa A., Fujisawa Y., Fukuda T., Fukui T., Furukawa N., Furukawa T., Furumoto W., Goto T., Hamaoka M., Hanazono N., Hasegawa K., Hatsuno T., Hayashi Y., Higuchi K., Hirasawa K., Hirayama H., Hirose M., Hirota S., Honda M., Ido T., Iiji O., Ikeda H., Ikeda K., Ikeoka K., Imaizumi M., Inaba H., Inoue T., Iseki F., Ishihara A., Ishioka N., Ito N., Iwase T., Kakuda H., Kamata J., Kanai H., Kanda H., Kaneko M., Kano H., Kasai T., Kato T., Kato Y., Kawada Y., Kawai K., Kawakami K., Kawakami S., Kawamoto T., Kawano S., Kim J., Kira T., Kitazawa H., Kitazumi H., Kito T., Kobayashi T., Koeda T., Kojima J., Komatsu H., Komatsu I., Koshibu Y., Kotani T., Kozuka T., Kumai Y., Kumazaki T., Maeda I., Maeda K., Maruyama Y., Matsui S., Matsushita K., Matsuura Y., Mineoi K., Mitsuhashi H., Miura N., Miyaguchi S., Miyajima S., Miyamoto H., Miyashita A., Miyata S., Mizuguchi I., Mizuno A., Mori T., Moriai O., Morishita K., Murai O., Nagai S., Nagata E., Nagata H., Nakagomi A., Nakahara S., Nakamura M., Nakamura R., Nakanishi N., Nakayama T., Nakazato R., Nanke T., Nariyama J., Niijima Y., Niinuma H., Nishida Y., Nishihata Y., Nishino K., Nishioka H., Nishizawa K., Niwa I., Nomura K., Nomura S., Nozoe M., Ogawa T., Ohara N., Okada M., Okamoto K., Okita H., Okuyama M., Ono H., Ono T., Pearce Y. O., Oriso S., Ota A., Otaki E., Saito Y., Sakai H., Sakamoto N., Sakamoto Y., Samejima Y., Sasagawa Y., Sasaguri H., Sasaki A., Sasaki T., Sato K., Sawano M., Seki S., Sekine Y., Seta Y., Sezaki K., Shibata N., Shiina Y., Shimono H., Shimoyama Y., Shindo T., Shinohara H., Shinohe R., Shinozuka T., Shirai T., Shiraiwa T., Shozawa Y., Suga T., Sugimoto C., Suzuki K., Suzuki S., Suzuki Y., Tada M., Taguchi A., Takagi T., Takagi Y., Takahashi K., Takahashi S., Takai H., Takanaka C., Take S., Takeda H., Takei K., Takenaka K., Tana T., Tanabe G., Taya K., Teragawa H., Tohyo S., Toru S., Tsuchiya Y., Tsuji T., Tsuzaki K., Uchiyama H., Ueda O., Ueyama Y., Wakaki N., Wakiyama T., Washizuka T., Watanabe M., Yamada T., Yamagishi T., Yamaguchi H., Yamamoto T., Yamaura M., Yamazoe M., Yasui K., Yokoyama Y., Yoshida K., Ching C. K., Foo C. G., Chow J. H., Chen D. D., Jaufeerally F. R., Lee Y. M., Lim G., Lim W. T., Thng S., Yap S. Y., Yeo C., Pak H. N., Kim J. -B., Kim J. H., Jang S. -W., Kim D. H., Ryu D. R., Park S. W., Kim D. -K., Choi D. J., Oh Y. S., Cho M. -C., Kim S. -H., Jeon H. -K., Shin D. -G., Park J. S., Park H. K., Han S. -J., Sung J. H., Cho J. -G., Nam G. -B., On Y. K., Lim H. E., Kwak J. J., Cha T. -J., Hong T. J., Park S. H., Yoon J. H., Kim N. -H., Kim K. -S., Jung B. C., Hwang G. -S., Kim C. -J., Kim D. B., Ahn J. J., An H. J., Bae H., Baek A. L., Chi W. J., Choi E. A., Choi E. H., Choi H. K., Choi H. S., Han S., Heo E. S., Her K. O., Hwang S. W., Jang E. M., Jang H. -S., Jang S., Jeon H. -G., Jeon S. R., Jeon Y. R., Jeong H. K., Jung I. -A., Kim H. J., Kim J. S., Kim J. A., Kim K. T., Kim M. S., Kim S. H., Kim Y. -I., Lee C. S., Lee E. H., Lee G. H., Lee H. Y., Lee H. -Y., Lee K. H., Lee K. R., Lee M. S., Lee M. -Y., Lee R. W., Lee S. E., Lee S. H., Lee S., Lee W. Y., Noh I. K., Park A. R., Park B. R., Park H. N., Park J. H., Park M., Park Y., Seo S. -Y., Shim J., Sim J. H., Sohn Y. M., Son W. S., Son Y. S., Song H. J., Wi H. K., Woo J. J., Ye S., Yim K. H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. C., Costabel J. P., Costamagna O. J. A., Damonte A. A., De Urquiza I. N., Diez F., Eden M. F., Fanuele M., Voena F. F., Torres M. F., Funosas C., Giacomi M. P., Gimenez C. H., Gurfinkel E. P., Had M. D. L. M., Hansen V., Hrabar A. D., Ingratta M., Lopez A., Maehara G., Maffei L., Martinelli A., Martinelli C., Matkovich J., Mautner B., Meirino A., Munguia R., Navarro A., Novas V., Prados G. P., Pontoriero J., Potito R. N., Ricotti C., Rodriguez M. A., Rolandi F., Palladino M. E. S., Salinger M., Sanziani L. S., Schygiel P. O., Sossich A., Tinto J. F., Tonelli L., Tufare A. L., Vallejo M., Yunis M. E., Zillo M., Zurbrigk F. J., Filho D. C. S., Jaber J., Armaganijan D., Neto J. F., Steffens A., de Souza W. K. S. B., de Souza Neto J. D., Ribeiro J. M., Teixeira M. S., Rossi P. R. F., Pires L., Moreira D., Jorge J. C. M., Filho A. M. L., Bodanese L. C., Montera M. W., Del Carlo C. H., Rodrigues T. D. R., da Costa F. A. A., Lopes A., Lopes R., Araujo G. R., Manenti E. R. F., Saraiva J. F. K., Braga J. C. F., Negri A., Souto L., Moncada C., Precoma D. B., Roquette F., Reis G., Filho R. A. R., Figueiredo E. L., Botelho R. V., Tavares C. M. D. F., Frack C. R. C., Saad J. A., Finimundi H. C., Pisani C., Chemello D., Martins M. P., Franca C. C. B., Alban F., Rosito G. B. A., Moraes Junior J. B. M. X., Tumelero R. T., Maia L. N., de Almeida R. S., do Carmo Borges N. C., Ferreira L. G. G., Agliardi P., Gomes J. A. O., Araujo V., Nakazone M. A., Barbosa T., Barroso S., Falchetto E. B., Lopes H. B., Lemos M. A. B. T., Biazus G., Queiroz L. B., Camazzola F. E., Caporale M., Cardoso Boscato S., Chieza F., Chokr M. O., Mingireanov R. C., Goes N. C., Correa C., Costa M., Ortiz C. C., da Silva L. S., Paulitsch F. D. S., da Silveira J. A., Daros E., de Araujo G. R., Del Monaco M. I., Dias C., Dias M. A., Wainstein A. P. D., Pizzato P. E., Esteves D. C., Fabri P., Fonseca T. F. L., Fernandes E., Fonseca C., Costantini C. R. F., Ferraz R. F., Freire F., Gottardo P., Guanaes D., Guizzardi S., Magedanz E. H., Igansi F., Jannuzzi F., Junior G., Komar D., Lino E. G., Lopes D., Junior O. L. D. S., Lustosa E., Macagnan A. P., Marinho M. C., Mazzoni M., Melo G., Mortari L., Mouco O. M. C. C., Vital C. N., Ormundo C., Emmer S. O., Palmegiani E., Pavani R., Pereira L., Pereira V. L., Perreira R., Poletti S., Fortunato S. C. Q., Queirantes C., Pereira N. R., Rech R. L., Ribeiro S., Rodrigues A., Roesch H., Reichert T. R., Santos D., Santos I., Santos M., Seroqui M. V., Silva S., Soares L., Spolaor L., Stoll C., Duda N. T., Trama L., Unterkircher B., Valois M. V., Vargas T., Viana T., Vicente C., Armaganijan L. V., Homem R. V., Torres L. G. V., Vila L., Filho F. V. G., Eggers G., Gutierrez C. B., Arriagada G., Cardenas S. P., Fernandez B. A. J. S., Conejeros C., Houzvic C., Cuevas P. M., Montecinos H., Forero A., Lanas F., Gomez M. L., Vilches G. C., Rey C., Astudillo C., Aguilar J., Campisto Y., Lara C., Molina E., Oyarzon J. M., Olguin V., Vergara M., Villan C., Diaz J. I., Cantu R. L., Zavala M. G. R., Jardines R. C., Zavaleta N. E., Umana S. V., Rosas E. L., Esperon G. L., Pozas G., Munoz E. C., Hernandez N. M., Rendon A. L., Hernandez N. G., Ibarra M. L. R., Carrillo L. V., Villezca D. L., Herrera C. H., Prieto J. J. L., Rodriguez R. G., Espinosa E. V., Martinez D. F., Barcena J. V., Yong R., Briones I. R., Pons J. L. L., Lopez H. A., Ruiz R. O., de la Vega C. D., Brito C. C., Valenzuela E. C., Reyes-Sanchez R., Ruiz A. B., Flores O. N., Gonzalez M. B., Nava R. A., Cerda J. D. M., Fierro O. F., Campos P. F., Alfaro T. A. A., Bellorin S. A., Avena R., Chavarria M., Espinosa I., Silva F. F., Nava R. H. G., Godoy K., Felix E. J. G., Garcia C. L. G., Salas L. G. G., Guajardo P., Gonzalez S. H., Izquierdo T., Ortiz M. C. M., Vasquez D. M., Mendoza N., Morales J., Nikitina N., Aybar S. O., Ortiz A., Macias P. P., Perez F., Sanchez J. A. P., Toledano S. P., Gonzalez M. R., Ramos C. R., Castro V. R., Cardona G. R., Cornejo M. R., Salinas A., Santana G., Perez P. S., Castaneda A. C. T., Cortes R. T., Lenz K., Drexel H., Foechterle J., Hagn C., Podczeck-Schweighofer A., Huber K., Winkler M., Schneeweiss B., Gegenhuber A., Lang W., Eichinger-Hasenauer S., Kaserer P., Sykora J., Rasch H., Pichler M., Schaflinger E., Strohmer B., Breier R., Ebner K. -M., Eischer L., Freihoff F., Lischka-Lindner A., Mark T., Mirtl A., Said A., Stocklocker C., Vogel B., Vonbank A., Wohrer C., Zanolin D., Paparella G., Vandergoten P., Parque J. -L., Capiau L., Vervoort G., Wollaert B., Desfontaines P., Mairesse G., Boussy T., Godart P., De Wolf A., Voet J., Heyse A., Hollanders G., Anne W., Vercammen J., Purnode P., Blankoff I., Faes D., Balthazar Y., Beutels M., Marechal P., Verstraete S., Xhaet O., Striekwold H., Thoeng J., Hermans K., Alzand B., Ascoop A. -K., Banaeian F., Barbuto A. -M., Billiaux A. C., Blockmans M., Bouvy C., Brike C., Capiau H., Casier T., Bolado A. C. Y., De Cleen D., De Coninck M., de Vos M., de Weerdt N., Delforge M., Delvigne M., Denie D., Derycker K., Deweerd E., Dormal F., Drieghe S., Everaert M., Eykerman T., Feys E., Ghekiere M., Gits F., Hellemans S., Helvasto L., Jacobs C., Lips S., Mestdagh I., Nimmegeers J., Piamonte V., Pollet P., Postolache A., Raepers M., Raymenants E., Richa J., Rombouts H., Salembier J., Scheurwegs C., Semeraro O., Simons N., Smessaert C., Smolders W., Stockman I., Tahon S., Thyssen V., Tincani G., Van Durme F., Van Lier D., Vandekerckhove H., Vandekerckhove Y., Vandenbroeck D., Vandorpe A., Vanhalst E., Vanhauwaert B., Vantomme C., Vergauwen L., Verloove H., Vydt T., Weyn T., Reichert P., Spacek R., Machova V., Zidkova E., Ludka O., Olsr J., Kotik L., Plocova K., Racz B., Ferkl R., Hubac J., Kotik I., Monhart Z., Burianova H., Jerabek O., Pisova J., Petrova I., Dedek V., Honkova M., Podrazil P., Spinar J., Vitovec J., Novak M., Lastuvka J., Durdil V., Antonova P., Bockova L., Bultas J., Chlumsky J., Dastychova L., Drasnar T., Honek J., Horejsi M., Hubacova V., Janska L., Kopeckova I., Kratochvilova R., Krcova E., Labrova R., Lindourkova A., Lipoldova J., Lubanda H., Ludkova A., Mahdalikova L., Majernikova M., Michalik D., Potuznik P., Prochazkova E., Sulc A., Sveceny J., Valtova M., Zidek M., Zika J., Nielsen H., Husted S., Hintze U., Rasmussen S., Bremmelgaard A., Markenvard J., Boerger J., Solgaard J., Simonsen P., Loekkegaard T., Bruun M., Mertz J., Dominguez H., Skagen K., Egstrup K., Ibsen H., Raymond I., Bang-Hansen T., Ellervik C., Eriksen E., Jensen L., Jensen M., Leth M., Nygaard A., Park J., Schou M., Therkelsen A., Tilma J., Vesterager K., Airaksinen J., Arola O., Koistinen J., Nappila H., Peltomaki K., Rasanen V., Vasankari T., Galinier M., Gottwalles Y., Paganelli F., Loiselet P., Muller J. -J., Koujan M. B., Marquand A., Destrac S., Piot O., Delarche N., Cebron J. -P., Boveda S., Guenoun M., Guedj-Meynier D., Galley D., Ohayon J., Assouline S., Zuber M., Amarenco P., Ellie E., Kadouch J., Fournier P. -Y., Huberman J. -P., Lemaire M., Rodier G., Milandre L., Vandamme X., Sibon I., Neau J. -P., Mahagne M. H., Mielot A., Bonnefoy M., Churet J. -B., Navarre V., Sellem F., Monniot G., Boyes J. -P., Doucet B., Martelet M., Obadia D., Crousillat B., Mouallem J., Bearez E., Nazeyrollas P., Brugnaux J. P., Fedorowsky A., Casassus F., Berneau J. -B., Chemin F., Falvo N., Perron J. -M., Poulard J. -E., Barreau A., Beltra C., Corrihons E., Decarsin N., Dubois B., Ducasse E., Giry X., Kemmel A., Ledure S., Lemaire N., Robin F., Rosolin N., Sanchez D., Suissa A., Koniger G., Purr J., Gerbaulet U., Kellner B. -T., Kopf A., Schafer T., Zauzig H., Riegel P., Hohensee H., Eissfeller E., Eder W., Rehling G., Glatzel D., Zutz S., Heinz G. -U., Menke H., Pustelnik A., Sandow P., Ludwig N., Wiswedel H., Wildenauer W., Axthelm C., Schwarz T., Babyesiza A., Stuchlik G., Zimny H. -H., Kropp M., Kahl F., Caspar A., Omankowsky S., Lassig T., Hartmann H. -J., Lehmann G., Bindig H. -W., Hergdt G., Reimer D., Hauk J., Dorsch W., Dshabrailov J., Michel H., Rapp K. -A., Vormann R., Mayer P., Horstmeier U., Eissing V., Hey H., Leuchtgens H., Lilienweiss V., Kolitsch K., Schubert C., Lauer H., Buchner T., Brauer G., Kamin S., Muller K., Abdel-Qader M., Baumbach S., Ebert H. -H., Schwencke C., Schellong S., Bernhardt P., Karolyi L., Sievers B., Haverkamp W., Salbach P., Rohnisch J. -U., Schoen S., Erdle W., Mueller T., Mueller H., Mitrovic V., Babjakova Z., Bergner K., Boehme S., Bonin K., Buckert D., Busch F., Dichristin U., Diez S., Fleck A., Flint K., Floegel H., Fritz C., Frommhold R., Gehre J., Geyer J., Grytzmann A., Hahn M., Helgert K., Hubert K., Kirchner-Volker K., Klein V., Kroll D., Krueger A., Lehmann R., Mann L., Maselli A., Menken G., Mikes K., Mortan H., Nasser N., Nicolaus D., Plauskat A., Pomper L., Quietzsch A., Ravenhorst C., Reichelt C., Reimer C., Schaefer B., Scharrer S., Schirmer K., Schmidt K., Schoene R., Schulze J., Schuppe M., Simon S., Sommer S., Spranger K., Talkenberger A., Tauber K., Tetlak A., Toennishoff T., Voelkel-Babyesiza R., Voigts B., Weiser U., Wesendorf S., Wildenauer S., Wolf T., Wurziger J., Zak J., Zauzig H. -D., Ziefle S., Zincke S., Vangel S., Szalai G., Merkely B., Kancz S., Boda Z., Nagy A., Laszlo Z., Matoltsy A., Gaszner B., Polgar P., Habon T., Noori E., Juhasz G., Kanakaridisz N., Szentpeteri I., Juhasz F., Vertes A., Papp A., May Z., Ferenczi J., Egyutt M., Kis E., Engelthaler G., Szantai G., Fulop E., Gombos P., Gulyas D., Jen P., Kiralyhazine Gyorke E., Kovacs M., Kovacsne Levang S., Marianna S., Radics Z., Sydo N., Szalo R., Szilagyi A., Sztanyik F., Vandrus B., Tiraferri E., Santoro R., Testa S., Di Minno G., Moia M., Caimi T. 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C., Sabir A., Choudhary F., Khalaque S., Wilson A., Peters S., Coulson W., Roberts N., Heer A., Coates S., Ward B., Jackson D., Walton S., Shepherd D., Sterry M., Wong T., Boon M., Bunney R., Haria-Shah R., Baron R. T., Davies S., Schatzberger T., Hargreaves N., Stephenson T., Choi H., Batson R., Lucraft L., Myhill T., Estifano S., Geatch D., Wilkinson J., Veale R., Forshaw K., Davies T., Zaman K., Vinson P., Liley C., Bandrapalli M., McGinty P., Wastling R., McEleny P., Beattie A., Cooke P., Wong M., Gunasegaram J., Pugsley M., Ahmad S., A'Court C., Ayers J., Bennett J., Cartwright S., Dobson S., Dooldeniya C., Flynn A., Fox R., Goram J., Halpin A., Hay A., Jacobs P., Jeffers L., Lomax L., Munro I., Muvva R., Nadaph M., Powell K., Randfield S., Redpath D., Reed R., Rickenbach M., Rogers G., Saunders P. 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M., Singh R., Naguib A., Abu-Mahfouz M., Al Omairi M., Al Naeemi A., Maruthanayagam R., Bazargani N., Wassef A., Gupta R., Khan M., Subbaraman B., Abdul A., Al Mulla A., El Bardisy S., Haridas P., Jadhav S., Magdaluyo K., Makdad M., Maqsood I., Mohamed R., Sharma N., Sharma R., Thanzeel M., Canosa R., Rama P., Blumberg E., Garcia J., Mullen P., Wilson V., Quick A., Ferrick K., Kutayli W. M., Cox M., Franco M., Falkowski S., Mendelson R., Williams M., Miller S., Beach S., Alfieri A., Gutowski T., Haque I., Reddy R., Ahmed W., Delafontaine P., Diercks D., Theodoro D., Remmel K., Alberts M., Ison R., Noveck H., Duffy P., Pitta S., Nishijima D., Treasure C., Asafu-Adjaye N., Ball K., Bartlett M., Bentley M., Bowers S., Brown A., Browne A., Cameron-Watts J., Canova M., Cassidy D., Cervellione K., Congal S., DePauw J., Dickerson A., Eley M., Evans L., Felpel S., Ferdinand K., Fielder D., Gentry P., Haideri A., Hakimi F., Harbour T., Hartranft E., Hawkins B., Headlee M., Henson L., Herrick C., Hicks T., Jasinski S., Jones A., Jones L., Jones P., Karl S., Keeling M., Kerr J., Knowles P., Langdon J., Lay M., Lee J. A., Lincoln T., Malone E., Merliss A., Merritt D., Minardo J., Mooso B., Orosco C., Palumbo V., Parker M., Parrott T., Paserchia S., Pearl G., Peterson J., Pickelsimer N., Purcell T., Raynor J., Raziano S., Richard C., Richardson T., Robertson C., Sage A., Sanghera T., Shaw P., Shoemaker J., Smith K., Stephanie B., Thatcher A., Theobald H., Thompson N., Treasure L., Tripti T., Verdi C., Worthy V., Jerjes-Sanchez, C, Corbalan, R, Barretto, A, Luciardi, H, Allu, J, Illingworth, L, Pieper, K, Kayani, G, Fitzmaurice, D, Goto, S, Hacke, W, Mantovani, L, Turpie, A, Gersh, B, Gibbs, H, Brodmann, M, Cools, F, Connolly, S, Spyropoulos, A, Eikelboom, J, Hu, D, Jansky, P, Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Darius, H, Keltai, M, Kakkar, S, Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Diaz, C, ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Lim, T, Jacobson, B, Oh, S, Vinolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Parkhomenko, A, Al Mahmeed, W, Chen, K, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Wang, F, Li, H, Yang, Z, Bai, C, Chen, X, Feng, S, Fu, Q, Gao, X, Guo, W, He, R, He, X, Hu, X, Huang, X, Li, B, Li, J, Li, L, Li, Y, Liu, T, Liu, W, Liu, Y, Lu, Z, Luo, X, Ma, T, Peng, J, Sheng, X, Shi, X, Sun, Y, Tian, G, Wang, K, Wang, L, Wu, R, Xie, Q, Xu, R, Yang, J, Yang, L, Yang, Q, Ye, Y, Yu, H, Yu, J, Yu, T, Zhai, H, Zhan, Q, Zhang, G, Zhang, Q, Zhang, R, Zhang, Y, Zheng, W, Zhou, B, Zhou, Z, Zhu, X, Jadhav, P, Durgaprasad, R, Ravi Shankar, A, Rajput, R, Bhargava, K, Sarma, R, Srinivas, A, Roy, D, Nagamalesh, U, Chopda, M, Kishore, R, Kulkarni, G, Chandwani, P, Pothiwala, R, Padinhare Purayil, M, Shah, S, Chawla, K, Kothiwale, V, Raghuraman, B, Vijayaraghavan, G, Vijan, V, Bantwal, G, Bisne, V, Khan, A, Gupta, J, Kumar, S, Jain, D, Abraham, S, Adak, D, Barai, A, Begum, H, Bhattacharjee, P, Dargude, M, Davies, D, Deshpande, B, Dhakrao, P, Dhyani, V, Duhan, S, Earath, M, Ganatra, A, Giradkar, S, Jain, V, Karthikeyan, R, Kasala, L, Kaur, S, Krishnappa, S, Lawande, A, Lokesh, B, Madarkar, N, Meena, R, More, P, Naik, D, Prashanth, K, Rao, M, Rao, N, Sadhu, N, Shah, D, Sharma, M, Shiva, P, Singhal, S, Suresh, S, Vanajakshamma, V, Panse, S, Kanamori, S, Yamamoto, K, Kumagai, K, Katsuda, Y, Sadamatsu, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Shiraishi, K, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, K, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Tatematsu, H, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Fudo, T, Obunai, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Yoshida, H, Ikeda, D, Ishizawa, M, Nakatsuka, M, Murata, K, Ogurusu, C, Shimoyama, M, Akutsu, M, Takamura, I, Hoshino, F, Yokota, N, Iwao, T, Tsuchida, K, Takeuchi, M, Hatori, Y, Kitami, Y, Nakamura, Y, Oyama, R, Ageta, M, Go, Y, Mishima, K, Unoki, T, Morii, S, Shiga, Y, Sumi, H, Nagatomo, T, Sanno, K, Fujisawa, K, Atsuchi, Y, Nagoshi, T, Seto, T, Tabuchi, T, Kameko, M, Nii, K, Oshiro, K, Takezawa, H, Nagano, S, Miyamoto, N, Iwaki, M, Fujii, M, Okawa, M, Abe, M, Saito, T, Mito, T, Nagao, K, Minami, J, Mita, T, Sakuma, I, Taguchi, T, Marusaki, S, Doi, H, Tanaka, M, Fujito, T, Matsuta, M, Kusumoto, T, Kakinoki, S, Ashida, K, Yoshizawa, N, Agata, J, Arasaki, O, Manita, M, Ikemura, M, Fukuoka, S, Murakami, H, Matsukawa, S, Hata, Y, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Inagaki, M, Odakura, H, Ueda, T, Katsube, Y, Nakata, A, Watanabe, H, Techigawara, M, Igarashi, M, Taga, K, Kimura, T, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Mizuguchi, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Okuda, F, Nagasaka, S, Abe, Y, Adachi, T, Akahane, K, Amano, T, Aoki, K, Aoyama, T, Arai, H, Arima, S, Arino, T, Asano, H, Asano, T, Azuma, J, Baba, T, Betsuyaku, T, Chibana, H, Date, H, Doiuchi, J, Emura, Y, Endo, M, Fujii, Y, Fujiki, R, Fujisawa, A, Fujisawa, Y, Fukuda, T, Fukui, T, Furukawa, N, Furukawa, T, Furumoto, W, Goto, T, Hamaoka, M, Hanazono, N, Hasegawa, K, Hatsuno, T, Hayashi, Y, Higuchi, K, Hirasawa, K, Hirayama, H, Hirose, M, Hirota, S, Honda, M, Ido, T, Iiji, O, Ikeda, H, Ikeda, K, Ikeoka, K, Imaizumi, M, Inaba, H, Inoue, T, Iseki, F, Ishihara, A, Ishioka, N, Ito, N, Iwase, T, Kakuda, H, Kamata, J, Kanai, H, Kanda, H, Kaneko, M, Kano, H, Kasai, T, Kato, T, Kato, Y, Kawada, Y, Kawai, K, Kawakami, K, Kawakami, S, Kawamoto, T, Kawano, S, Kim, J, Kira, T, Kitazawa, H, Kitazumi, H, Kito, T, Kobayashi, T, Koeda, T, Kojima, J, Komatsu, H, Komatsu, I, Koshibu, Y, Kotani, T, Kozuka, T, Kumai, Y, Kumazaki, T, Maeda, I, Maeda, K, Maruyama, Y, Matsui, S, Matsushita, K, Matsuura, Y, Mineoi, K, Mitsuhashi, H, Miura, N, Miyaguchi, S, Miyajima, S, Miyamoto, H, Miyashita, A, Miyata, S, Mizuguchi, I, Mizuno, A, Mori, T, Moriai, O, Morishita, K, Murai, O, Nagai, S, Nagata, E, Nagata, H, Nakagomi, A, Nakahara, S, Nakamura, M, Nakamura, R, Nakanishi, N, Nakayama, T, Nakazato, R, Nanke, T, Nariyama, J, Niijima, Y, Niinuma, H, Nishida, Y, Nishihata, Y, Nishino, K, Nishioka, H, Nishizawa, K, Niwa, I, Nomura, K, Nomura, S, Nozoe, M, Ogawa, T, Ohara, N, Okada, M, Okamoto, K, Okita, H, Okuyama, M, Ono, H, Ono, T, Pearce, Y, Oriso, S, Ota, A, Otaki, E, Saito, Y, Sakai, H, Sakamoto, N, Sakamoto, Y, Samejima, Y, Sasagawa, Y, Sasaguri, H, Sasaki, A, Sasaki, T, Sato, K, Sawano, M, Seki, S, Sekine, Y, Seta, Y, Sezaki, K, Shibata, N, Shiina, Y, Shimono, H, Shimoyama, Y, Shindo, T, Shinohara, 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J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. 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M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. 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M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Latin Americans ,030204 cardiovascular system & hematology ,outcomes ,0302 clinical medicine ,Drug Prescription ,Retrospective Studie ,Risk Factors ,Atrial Fibrillation ,Antithrombotic ,Prospective Studies ,Registries ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Stroke ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,Treatment Outcome ,Stroke prevention ,outcome ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,medicine.drug_class ,Clinical Investigations ,Hemorrhage ,antithrombotic treatment ,Drug Prescriptions ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mexico ,Aged ,Retrospective Studies ,Fibrillation ,business.industry ,Risk Factor ,Anticoagulants ,South America ,medicine.disease ,Drug Utilization ,Clinical trial ,Prospective Studie ,Latin American ,antithrombotic treatment, atrial fibrillation, Latin American, outcomes ,business - Abstract
Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2019
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20. The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review
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Elena Cantone, Stefania Gallo, Sara Torretta, Aikaterini Detoraki, Carlo Cavaliere, Claudio Di Nola, Luca Spirito, Tiziana Di Cesare, Stefano Settimi, Daniela Furno, Lorenzo Pignataro, Eugenio De Corso, Cantone, Elena, Gallo, Stefania, Torretta, Sara, Detoraki, Aikaterini, Cavaliere, Carlo, Di Nola, Claudio, Spirito, Luca, Di Cesare, Tiziana, Settimi, Stefano, Furno, Daniela, Pignataro, Lorenzo, and De Corso, Eugenio
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chronic rhinosinusitis ,precision medicine ,AIT ,Medicine (miscellaneous) ,LAR ,SCIT ,SLIT ,adenotonsillar disease ,immunotherapy ,otitis ,personalized medicine ,otiti ,chronic rhinosinusiti - Abstract
Previous studies have demonstrated that both subcutaneous (SCIT) and sublingual specific immunotherapy (SLIT) are effective in treating allergic rhinitis (AR). Further studies have evaluated the efficacy of allergen-specific immunotherapy (AIT) on different ear, nose, and throat (ENT) manifestations, in which allergy might have an etiopathogenetic role, such as local allergic rhinitis (LAR), rhinosinusitis (RS), otitis media (OM), and adenotonsillar (AT) disease. Nevertheless, the management of allergy in ENT diseases is still debated. To the best of our knowledge, this is the first systematic review assessing the efficacy of AIT in ENT diseases aside from AR. Literature data confirmed that AIT might be an effective therapeutic option in LAR, although its effect is restricted to studies with short-term follow-up. Furthermore, previous research demonstrated that AIT may improve symptoms and surgical outcomes of chronic rhinosinusitis when used as an adjunctive treatment. Few studies supported the hypothesis that AIT may exert positive therapeutic effects on recurrent upper airway infections as adenotonsillar disease. Finally, some clinical observations suggested that AIT may add some benefits in the management of otitis media with effusion (OME). The results of this systematic review allow us to conclude that the efficacy of AIT in ENT disorders has been only slightly investigated and additional studies are needed.
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- 2022
21. Effect of Cu Addition on the Corrosion and Antifouling Properties of PEO Coated Zinc-Aluminized Steel
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Luca Pezzato, Alessio Giorgio Settimi, Daniel Fanchin, Emanuela Moschin, Isabella Moro, and Manuele Dabalà
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General Materials Science ,Galvalume ,Plasma Electrolytic Oxidation ,antifouling ,anti-corrosion coatings - Abstract
In the present work, Plasma Electrolytic Oxidation (PEO) coatings were produced on zinc-aluminized carbon steels (Galvalume commercial treatment). In addition, copper particles of various sizes were introduced into the coating in order to produce samples with antifouling properties. The particles were successfully embedded into the coating. A higher number of embedded particles was observed when these are in sub-micrometric size and obtained in pulsed current. The presence of particles produces significant antifouling properties on the sample’s surfaces during the first 20 days of immersion. The presence of the particles reduces the corrosion resistance in comparison to the samples PEO coated without the particles; however, the corrosion resistance remain higher than the one of the untreated sample.
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- 2022
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22. Photoluminescent Plasma Electrolytic Oxidation Coatings Containing YAG: Ce Produced on 1050 Aluminum Alloy
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Settimi, Alessio Giorgio, Pezzato, Luca, Longato, Alessandro, Brunelli, Katya, Martucci, Alessandro, Gross, Silvia, and Dabala, Manuele
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Abstract
In this work, we investigated the possible incorporation of YAG (yttrium aluminum garnet)-Ce particles into plasma electrolytic oxidation (PEO) coatings on 1050AA (aluminum alloy) in order to endow the surface with photoluminescent properties. Different treatment times and current modes (direct or pulsed) were tested as PEO process parameters using as electrolyte a silicates-containing solution. The microstructure of the samples was characterized by SEM and XRD measurements, the corrosion properties were determined by EIS tests, whereas the photoluminescence was evaluated with a proper spectrometer. The concentration of the YAG-Ce particles incorporated in the PEO coating was strongly influenced by the current mode, and in particular, it was higher with pulsed current mode. A higher content of YAG-Ce particles results in a better corrosion resistance and photoluminescent effect. PEO process in pulsed unipolar mode using an electrolyte containing YAG-Ce particles resulted an effective way to produce samples of 1050AA with a surface characterized by photoluminescent properties.
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- 2022
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23. Efficient 2D LIDAR-Based Map Updating For Long-Term Operations in Dynamic Environments
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Stefanini, Elisa, Ciancolini, Emilio, Settimi, Alessandro, and Pallottino, Lucia
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Mapping ,Localization ,SLAM - Abstract
Long-time operations of autonomous vehicles and mobile robots in logistics and service applications are still a challenge. To avoid a continuous re-mapping, the map can be updated to obtain a consistent representation of the current environment. In this paper, we propose a novel LIDAR based occupancy grid map updating algorithm for dynamic environments. The proposed approach allows robust long-term operations as it can detect changes in the working area even in presence of moving elements. Results highlighting map quality and localisation performance, both in simulation and experiments, are reported.
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- 2022
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24. Proposal for a Structured Outpatient Clinic for Dupilumab Treatment in Chronic Rhinosinusitis with Nasal Polyps in the First Year of Treatment
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Sara Torretta, Eugenio De Corso, Nicolò Nava, Francesca Fraccaroli, Silvia Mariel Ferrucci, Stefano Settimi, Claudio Montuori, Davide Paolo Porru, Camilla Spanu, Giuseppe D’Agostino, Angelo Valerio Marzano, and Lorenzo Pignataro
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Settore MED/35 - Malattie Cutanee e Veneree ,clinical diagnostic flowchart ,dupilumab ,otolaryngology ,Medicine (miscellaneous) ,chronic rhinosinusitis with nasal polyps - Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease of the nose and paranasal sinuses with important economic and sanitary burdens, as well as having a great impact on patients’ quality of life. In this field, a new therapeutic approach for those patients who have been described as affected by severe uncontrolled CRSwNP, resistant to medical and best surgical treatment, is represented by subcutaneous human monoclonal antibodies (including dupilumab) that block specific targets involved in the type 2 inflammatory pathway which most commonly drives CRSwNP pathophysiology. This paper aims to report our experience in the management of severe uncontrolled CRSwNP and, in particular, describe our diagnostic workup including baseline evaluation and follow-up visits in the first year of treatment. We also describe into detail our multidisciplinary approach to the disease. We finally report the outcomes of treatment in a real-life setting. In this outpatient real-life setting, our results confirmed the effectiveness of dupilumab in reducing the volume of nasal polyps and restoring nasal obstruction and sense of smell, as well as improving patients’ quality of life. The adherence to the dupilumab treatment was very high. The dose of administration was never modified in patients in the first year of treatment. All the patients respected the plan of the visits at proposed time points. We believe that the structural organization of our outpatient clinic appears to be functional: it allows us to study patients thoroughly before starting treatment and to make a proper follow-up after it starts. We believe that sharing both our strict clinical flowchart and growing experience with dupilumab with the medical community can lead to more standardized and effective pathways of care for CRSwNP patients.
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- 2022
25. Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps: Identification of Unmet Clinical Needs
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Eugenio De Corso, Carlotta Pipolo, Elena Cantone, Giancarlo Ottaviano, Stefania Gallo, Frank Rikki Mauritz Canevari, Alberto Macchi, Giulia Monti, Carlo Cavaliere, Ignazio La Mantia, Sara Torretta, Francesco Bussu, Emanuele Scarano, Paolo Petrone, Angelo Ghidini, Daniela Lucidi, Massimiliano Garzaro, Matteo Trimarchi, Veronica Seccia, Giulio Cesare Passali, Daria Salsi, Domenico Cuda, Ernesto Pasquini, Luca Malvezzi, Stefano Settimi, Gaetano Paludetti, Jacopo Galli, De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Canevari, Frank Rikki Mauritz, Macchi, Alberto, Monti, Giulia, Cavaliere, Carlo, La Mantia, Ignazio, Torretta, Sara, Bussu, Francesco, Scarano, Emanuele, Petrone, Paolo, Ghidini, Angelo, Lucidi, Daniela, Garzaro, Massimiliano, Trimarchi, Matteo, Seccia, Veronica, Passali, Giulio Cesare, Salsi, Daria, Cuda, Domenico, Pasquini, Ernesto, Malvezzi, Luca, Settimi, Stefano, Paludetti, Gaetano, and Galli, Jacopo
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corticosteroid ,chronic rhinosinusitis ,unmet needs ,Medicine (miscellaneous) ,with nasal polyps ,chronic rhinosinusitis with nasal polyps ,unmet need ,corticosteroids ,chronic rhinosinusiti ,survey ,management ,Settore MED/31 - OTORINOLARINGOIATRIA - Abstract
Background: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in Italy to capture current trends in the use of topical and systemic corticosteroids in patients with CRSwNP. Methods: A survey was set up on Survey Monkey®. Each author distributed the link to the survey in an ad hoc manner and a total of 437 participants filled out the survey. Results: Mometasone furoate (79.3%) was the most frequently prescribed, administered daily by 61.9% of participants; the remaining preferred to discontinue treatment for brief periods to reduce side effects or to modulate the therapy in mild cases. The majority believe that a short cycle of systemic steroids should be prescribed for re-exacerbation of symptoms and that the number of cycles in the previous year should be evaluated to define control of the disease even if international guidelines do not provide clear indications on this topic. A certain degree of divergence emerged from responses regarding how long and the maximal dose of systemic steroids which place patients at high risk for adverse events. Finally, systemic corticosteroids seem to offer only temporary benefit on recovery of smell without guaranteeing long-term control even if the patient is adherent to topical corticosteroids. Conclusions: Our results highlight the need for clear guidelines on oral steroids, which could help supporting the use of a precision medicine approach, including indications for new biological agents.
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- 2022
26. Efficacy of Biologics on Refractory Eosinophilic Otitis Media Associated with Bronchial Asthma or Severe Uncontrolled CRSwNP
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Eugenio De Corso, Claudio Montuori, Stefano Settimi, Dario Antonio Mele, Alessandro Cantiani, Marco Corbò, Elena Cantone, Gaetano Paludetti, Jacopo Galli, De Corso, E., Montuori, C., Settimi, S., Mele, D. A., Cantiani, A., Corbo, M., Cantone, E., Paludetti, G., and Galli, J.
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Eosinophilic otitis media ,Type-2 inflammation ,Chronic rhinosinusitis ,Biologic ,Chronic rhinosinusiti ,eosinophilic otitis media ,biologics ,type-2 inflammation ,asthma ,chronic rhinosinusitis ,Settore MED/31 - OTORINOLARINGOIATRIA ,General Medicine ,Biologics ,Asthma - Abstract
Eosinophilic otitis media (EOM) is a difficult-to-treat otitis media characterized by eosinophilic accumulation in the middle ear mucosa and effusion. It is resistant to conventional treatments and strongly associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of our study is to evaluate the effectiveness of biologics drugs in the control of EOM. This is a retrospective no-profit real-life observational study, involving patients affected by refractory EOM and in treatment with different biologics for concomitant severe eosinophilic asthma or severe uncontrolled CRSwNP (Dupilumab: n = 5; Omalizumab: n = 1; Mepolizumab: n = 1; Benralizumab: n = 1). We analyzed data at baseline and at the 6-month follow-up, including specific nasal and otological parameters. We observed an improvement of all nasal outcomes, including NPS, SNOT-22, VAS, and smell function. Regarding specific otological parameters, we observed a significant reduction in the mean value of COMOT-15 score and of Otitis Severity Score at 6-month follow-up compared to baseline (p < 0.05). Finally, we observed an improvement in terms of air conduction hearing levels during the treatment. Our results demonstrated that anti type-2 inflammatory pathway biologics can be effective in improving symptoms control and in reducing the severity of eosinophilic otitis media when treating coexisting type-2 diseases, such as asthma and or CRSwNP.
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- 2022
27. Efficacy of indocyanine green (ICG) fluorescent cholangiography to improve intra-operative visualization during laparoscopic cholecystectomy in pediatric patients: a comparative study between ICG-guided fluorescence and standard technique
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Ciro Esposito, Alessandro Settimi, Mariapina Cerulo, Maria Escolino, Esposito, Ciro, Settimi, Alessandro, Cerulo, Mariapina, and Escolino, Maria
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Male ,Indocyanine Green ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Fluorescence ,chemistry.chemical_compound ,Cholangiography ,Laparoscopic ,Retrospective Studie ,Internal medicine ,medicine ,Humans ,Cholecystectomy ,Coloring Agents ,Child ,Coloring Agent ,Retrospective Studies ,ICG ,Pediatric ,medicine.diagnostic_test ,business.industry ,Bile duct ,Hepatology ,Dissection ,medicine.anatomical_structure ,chemistry ,Cholecystectomy, Laparoscopic ,Cystic duct ,Surgery ,Female ,Radiology ,business ,Indocyanine green ,Abdominal surgery ,Human - Abstract
BACKGROUND In the last few years, indocyanine green (ICG) fluorescent cholangiography (FC) has been adopted to perform intra-operative biliary mapping during laparoscopic cholecystectomy (LC). This study aimed to compare the results of LC with and without use of ICG-FC. METHODS All LC operated from June 2017 to June 2021 in our unit were retrospectively reviewed. Pre-operative workup included ultrasonography to assess dilation of main biliary tree. The ICG dosage was 0.35 mg/kg and the median timing of administration was 15.5 h pre-operatively. We evaluated, analyzing videorecorded procedures, 3 parameters in both groups: the total operative time (T1), the time of cystic duct isolation, clipping and sectioning (T2), and the time of gallbladder removal from hepatic fossa (T3). RESULTS Forty-three LC were operated in the study period: 22 using standard technique (G1) and 21 using ICG-FC (G2). There were 27 girls and 16 boys, with median age at surgery of 11.5 years (range 7-17) and median weight of 47 kg (range 31-110). No conversions were reported in our series. In all ICG cases (except one patient under therapy with phenobarbital) the biliary tree was perfectly visualized during dissection. Intra-operative complications occurred in 3 G1 patients (13.6%): 2 bleedings from the Calot's triangle and 1 bleeding from the liver bed during the gallbladder removal. LC was significantly faster in G2 than in G1 (p = 0.001). In fact, the parameters analyzed (T1, T2, T3) were all significantly greater in G1 than in G2 (p = 0.001). CONCLUSIONS Based upon our experience, we strongly recommend the use of ICG-FC in all pediatric patients undergoing LC. ICG-guided fluorescence provided an excellent real-time visualization of the extrahepatic biliary tree and allowed faster and safer dissection, minimizing the risk of bile duct injuries. Furthermore, ICG use was clinically safe, with no adverse reactions to the product.
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- 2022
28. Clinical Evidence of Type 2 Inflammation in Non-allergic Rhinitis with Eosinophilia Syndrome: a Systematic Review
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Eugenio De Corso, Veronica Seccia, Giancarlo Ottaviano, Elena Cantone, Daniela Lucidi, Stefano Settimi, Tiziana Di Cesare, Jacopo Galli, De Corso, E., Seccia, V., Ottaviano, G., Cantone, E., Lucidi, D., Settimi, S., Di Cesare, T., and Galli, J.
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Pulmonary and Respiratory Medicine ,Inflammation ,Immunology ,Type 2 inflammation ,Eosinophil ,Asthma ,Chronic rhiniti ,Eosinophils ,Chronic rhinosinusitis ,Nasal Polyps ,Nasal cytology ,Chronic rhinosinusiti ,Chronic Disease ,Eosinophilia ,Immunology and Allergy ,Chronic rhinitis ,Humans ,Non-allergic rhinitis ,Settore MED/31 - OTORINOLARINGOIATRIA ,Non-allergic rhiniti ,Sinusitis ,NARES ,Rhinitis - Abstract
Purpose of Review: Non-allergic rhinitis (NAR) includes different subtypes, among which NAR with eosinophilia syndrome (NARES) is the most important because of severity of symptoms and the high risk of comorbidities. Its pathophysiology is still object of debate, but a crucial role of chronic eosinophilic inflammation has been recognized. The aim of this review is to critically analyze the current evidence regarding the hypothesis that NARES may be considered a type 2 inflammatory disorder. Recent Findings: The definition and diagnostic criteria for NARES are not universally shared and adopted, thus generating difficulties in reproducing the results. At present, there is extreme heterogeneity in sampling methods and disagreement in the cut-off of local eosinophilic count to determine a diagnosis of NARES. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) standard was applied to identify English-language experimental and clinical articles regarding NARES. The search was performed in April 2021. Twenty-six articles were included. Summary: Our data suggest a particular heterogeneity regarding sampling and specific cut-offs adopted for diagnosis of NARES and consensus should be reached. We suggest that eosinophil count should be reported as an absolute value for at least 10 observed rich fields in order to increase the level of standardization. Consensus among authors on this topic should be reached with particular attention to the cut-off for diagnosis. In the future, this limitation may be overcome by the identification of repeatable biomarkers to refine diagnosis and prognosis of NARES. Furthermore, our data strongly suggest that NARES have numerous similarities with clinical features of the most common type 2 diseases such as eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP): late onset, association with type 2 comorbidities, selective eosinophilic tissue infiltration, remarkable response to oral and intranasal corticosteroids, and progression in a type 2 CRSwNP.
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- 2022
29. An Application of Graphical Modeling to the Analysis of Intranet Benefits and Applications
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Raffaella Settimi, Linda V. Knight, Theresa A. Steinbach, and James D. White
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- 2021
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30. Influence of Nickel on the Microstructure, Mechanical Properties, and Corrosion Resistance of Laser-Welded Super-Duplex Stainless Steel
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Vicente Afonso Ventrella, Andrea Zambon, Claudio Gennari, J. Gallego, E. J. da Cruz Junior, Alessio Giorgio Settimi, Fed Inst Sao Paulo, Universidade Estadual Paulista (Unesp), and Univ Padua
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inorganic chemicals ,Materials science ,microstructure ,Nd:YAG pulsed Laser Welding ,chemistry.chemical_element ,02 engineering and technology ,Welding ,mechanical properties ,01 natural sciences ,Indentation hardness ,Corrosion ,law.invention ,law ,YAG pulsed laser welding ,Ferrite (iron) ,0103 physical sciences ,Ultimate tensile strength ,Mechanical Properties ,Nickel Addition ,General Materials Science ,Nd ,Microstructure ,010302 applied physics ,Austenite ,corrosion resistance ,Mechanical Engineering ,Metallurgy ,technology, industry, and agriculture ,nickel addition ,Super-Duplex Stainless Steel ,respiratory system ,021001 nanoscience & nanotechnology ,Nickel ,Corrosion Resistance, Mechanical Properties, Microstructure, Nd:YAG pulsed Laser Welding, Nickel Addition, Super-Duplex Stainless Steel ,chemistry ,Mechanics of Materials ,Corrosion Resistance ,super-duplex stainless steel ,0210 nano-technology - Abstract
Made available in DSpace on 2021-06-25T12:40:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-19 Coimbra Group Super-duplex stainless steel (SDSS) exhibits an austenite-ferrite dual-phase structure, which promotes many benefits upon single-phase grades, such as high mechanical strength and corrosion resistance. Welding process results in an unbalanced microstructure, with large amount of ferrite, which compromise SDSS's properties. This paper investigates the effect of using electrolytic nickel foils as an addition metal on UNS S32750 SDSS Nd:YAG pulsed laser welding, through the evaluation of the microstructure, hardness, tensile strength, and corrosion resistance of the weld bead. Six conditions were investigated: autogenous welding and with addition of nickel, varying the thickness of nickel foil added. Microstructural analysis reveals an increase in volume fraction of austenite for the conditions with addition of nickel. Using a 30 mu m thick nickel foil, approximately equal amount of austenite and ferrite was obtained in the weld bead. The higher microhardness was obtained for the autogenous welding, 400 HV and decreased with the addition of nickel. The tensile strength decreased 4% in the experimental conditions with high nickel addition. The corrosion resistances were the same for all the conditions with addition on nickel, regardless of the nickel foil thickness added, but it compared to autogenous welding the CPT's increased approximately 14 degrees C. Fed Inst Sao Paulo, Ave Jeronimo Figueira Costa 3014, BR-15503110 Votuporanga, SP, Brazil Sao Paulo State Univ, Dept Mech Engn, Ave Brasil 56, BR-15385000 Ilha Solteira, SP, Brazil Univ Padua, Dept Ind Engn, Via Gradenigo 6-A, I-35131 Padua, Italy Univ Padua, Dept Management & Engn, Stradella S Nicola 3, I-36100 Vicenza, Italy Sao Paulo State Univ, Dept Mech Engn, Ave Brasil 56, BR-15385000 Ilha Solteira, SP, Brazil
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- 2021
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31. Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival
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Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Libero Lauriola, and Franco Oreste Ranelletti
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Cancer Research ,Parathyroid Hormone-Related Protein ,Cetuximab ,Prognosis ,Bio-radiotherapy with cetuximab ,Oncology ,Laryngeal cancer ,HER1 ,Genetics ,Humans ,Prognostic and predictive role ,Settore MED/31 - OTORINOLARINGOIATRIA ,Neoplasm Recurrence, Local ,Laryngeal Neoplasms ,PTHrP and PTH1R ,Receptor, Parathyroid Hormone, Type 1 ,Retrospective Studies - Abstract
Background Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer. Therefore, we studied the expression of PTHrP and its receptor, parathyroid hormone-related peptide receptor type 1 (PTH1R), in primary locally advanced laryngeal squamous cell carcinomas (LALSCC) also in relation to the clinical outcome of patients. Methods We conducted a retrospective exploratory study, using immunohistochemistry, on PTHrP, PTH1R and HER1 expressions in LALSCC of 66 patients treated with bio-radiotherapy with cetuximab. Results The expressions of PTHrP and PTH1R in LALSCC were associated with the degree of tumor differentiation (p = 0.01 and 0.04, respectively). Poorly differentiated tumors, with worse prognosis, expressed PTHrP at nuclear level and were PTH1R negative. PTHrP and PTH1R were expressed at cytoplasmic level in normal larynx epithelium and more differentiated laryngeal cancer cells, suggesting an autocrine/paracrine role of PTHrP in squamous cell differentiation of well differentiated tumors with good prognosis. Eighty-one percent HER1 positive tumors expressed PTHrP (p PTHrP gene by HER1 signaling. In multivariable analyses, patients with PTHrP positive tumors had a higher relative risk of relapse (HR = 5.49; CI 95% = 1.62–22.24; p = 0.006) and survival (HR = 8.21; CI 95% = 1.19–105.00; p = 0.031) while those with PTH1R positive tumors showed a lower relative risk of relapse (HR = 0.18; CI 95% = 0.04–0.62; p = 0.002) and survival (HR = 0.18; CI 95% = 0.04–0.91; p = 0.029). Conclusions In LALSCC nuclear PTHrP and absence of PTH1R expressions could be useful in predicting response and/or resistance to cetuximab in combined therapies, contributing to an aggressive behavior of tumor cells downstream to HER1.
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- 2022
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32. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Time Factors ,Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Risk Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Prevalence ,Prognosis ,Prospective Studies ,Survival Rate ,Thromboembolism ,Registries ,Risk Assessment ,Medicine ,030212 general & internal medicine ,Prospective cohort study ,Incidence (epidemiology) ,cardiovascular system ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Human ,medicine.medical_specialty ,Time Factor ,RD1-811 ,Prognosi ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Risk factor ,Survival rate ,Fibrillation ,business.industry ,Risk Factor ,ta3121 ,medicine.disease ,Clinical trial ,Prospective Studie ,RC666-701 ,Surgery ,Clinical and Preventive Cardiology ,business - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
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33. Effect of Precipitation Hardening on Corrosion Resistance of Cu-4.5 wt.%Ti
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Luca Pezzato, Denise Hanoz, Alessio Giorgio Settimi, and Manuele Dabalà
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010302 applied physics ,Materials science ,Mechanical Engineering ,Alloy ,Metallurgy ,Intermetallic ,02 engineering and technology ,engineering.material ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,Indentation hardness ,Corrosion ,Precipitation hardening ,Mechanics of Materials ,Phase (matter) ,0103 physical sciences ,engineering ,General Materials Science ,0210 nano-technology ,Polarization (electrochemistry) - Abstract
Cu-Ti alloys are one of the main candidates to act as a substitute for Cu-Be alloys due to their more environmentally friendly nature. Cu-Ti alloys are age hardenable alloys, and their treatments can modify their microstructure, causing the formation of various Cu-Ti intermetallic that can strongly influence both the mechanical and corrosion properties. In this work, the effect of homogenization heat treatment at 1173 K followed by aging at 723 K for different times (0–24 h) on the microstructure, corrosion and mechanical properties of Cu-4.5 wt.%Ti alloy was investigated. Moreover, the corrosion mechanism based on the different kinetics for the formation of the protective oxide layer was studied. The microstructure and phase analyses were analyzed with SEM and XRD. The mechanical properties were investigated by microhardness test, whereas the corrosion properties were studied by potentiodynamic anodic polarization and potentiostatic tests in artificial sweat. The results showed that the cast sample had the highest corrosion resistance, and the mechanical properties decrease with the homogenization treatment and increase after the combination of homogenization and aging. A corrosion mechanism correlated to the amount and type of intermetallic material was proposed.
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- 2021
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34. Global dynamics perspective on macro- to nano-mechanics
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Valeria Settimi and Giuseppe Rega
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Dynamical systems theory ,Computer science ,Applied Mathematics ,Mechanical Engineering ,Multiphysics ,Structural system ,Aerospace Engineering ,Ocean Engineering ,Control engineering ,01 natural sciences ,Chaos theory ,Variety (cybernetics) ,Nonlinear system ,Control and Systems Engineering ,0103 physical sciences ,Electrical and Electronic Engineering ,Macro ,Robustness (economics) ,010301 acoustics - Abstract
In about the last two decades, global nonlinear dynamics has been evolving in a revolutionary way, with the development of sophisticated techniques employing concepts/tools of dynamical systems, bifurcation, and chaos theory, and applications to a wide variety of mechanical/structural systems. The relevant achievements entail a substantial change of perspective in dealing with vibration problems and are ready to meaningfully affect the analysis, control, and design of systems at different scales, in multiphysics contexts too. After properly framing the subject within some main stages of developments of nonlinear dynamics in solid/structural mechanics, as occurred over the last 40 years, the article focuses on highlighting the role played by global analysis in unveiling the nonlinear response and actual safety of engineering systems in different environments. Reduced order models of macro-/micro-structures are considered. Global dynamics of a laminated plate with von Karman nonlinearities, shear deformability, and full thermomechanical coupling allows to highlight the meaningful effects entailed by the slow transient thermal dynamics on the fast steady mechanical responses. An atomic force microcantilever is referred to for highlighting the severe worsening of overall stability associated with the application of an external feedback control and the importance of global dynamics for conceiving and effectively implementing a control procedure aimed at enhancing engineering safety. The last part of the article dwells on the general role that a global dynamics perspective is expected to play in the safe design of real systems, in the near future, focusing on how properly exploiting concepts and tools of dynamical integrity to evaluate response robustness in the presence of unavoidable imperfections, and to improve the system’s actual load carrying capacity.
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- 2021
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35. Degradability and gas production of diets enriched with additives in cattle or sheep inoculum
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Daniel Staciarini Corrêa, Cristine dos Santos Settimi Cysneiros, Graciele Araújo de Oliveira, Reginaldo Nassar Ferreira, Aldi Fernandes de Souza França, Cirano José Ulhoa, Tayrone Freitas Prado, and Leonardo Guimarães de Oliveira
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Animal science ,Chemistry ,Production (economics) - Published
- 2021
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36. Clinical Markers of Need for Surgery in Orbital Complication of Acute Rhinosinusitis in Children: Overview and Systematic Review
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Elena Cantone, Eva Piro, Eugenio De Corso, Claudio Di Nola, Stefano Settimi, Giusi Grimaldi, Gaetano Motta, Cantone, Elena, Piro, Eva, De Corso, Eugenio, Di Nola, Claudio, Settimi, Stefano, Grimaldi, Giusi, and Motta, Gaetano
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acute rhinosinusitis ,orbital surgery ,proptosis ,orbital celluliti ,Medicine (miscellaneous) ,acute rhinosinusiti ,periorbital celluliti ,ophthalmoplegia ,children ,periorbital cellulitis ,orbital cellulitis ,proptosi ,FESS ,Settore MED/31 - OTORINOLARINGOIATRIA ,subperiosteal abscess - Abstract
Background: Although they can occur at all ages, orbital (OC) and periorbital cellulitis (POC) prevail in the pediatric population. Acute rhinosinusitis (ARS) is the most frequent predisposing factor of OC. Recent literature has suggested a medical management approach for OC and POC, with surgery reserved only for more severe cases. However, there is still a lack of consensus on the clinical markers of a need for surgery. The aim of this systematic review was to identify clinical markers of a need for surgery in children with OC. Our systematic review, in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process, yielded 1289 articles finally screened. This resulted in 31 full texts that were included in a qualitative analysis. The results of this review suggest that in children aged over 9 years, large subperiosteal orbital abscesses (SPOAs), impaired vision, ophthalmoplegia, proptosis, elevated C-reactive protein (CRP) and absolute neutrophil counts (ANC), hemodynamic compromise, no clinical improvement after 48/72 h of antibiotic therapy, and a Chandler III score or higher are clinical markers of the need for surgery. However, most of the studies are observational and retrospective, and further studies are needed to identify reliable and repeatable clinical markers of the need for surgery.
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- 2022
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37. Efficacy and long-term follow-up of positional therapy by vibrotactile neck-based device in the management of positional OSA
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Sabino Marrone, Gaetano Paludetti, Emanuele Scarano, Antonella Loperfido, Dario Antonio Mele, Antonella Fiorita, Rodolfo Francesco Mastrapasqua, Pasqualina Maria Picciotti, Stefano Settimi, Eugenio De Corso, and Grazia Rizzotto
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Sleep Apnea ,Long term follow up ,Polysomnography ,positional therapy ,vibrotactile neck-based device ,OSA ,03 medical and health sciences ,0302 clinical medicine ,Nightshift ,Humans ,Medicine ,obstructive sleep apnea ,Retrospective Studies ,POSA ,Sleep Apnea, Obstructive ,Obstructive ,business.industry ,medicine.disease ,Scientific Investigations ,positional OSA ,Obstructive sleep apnea ,Compliance (physiology) ,030228 respiratory system ,Neurology ,Physical therapy ,Settore MED/31 - OTORINOLARINGOIATRIA ,Neurology (clinical) ,business ,Neck ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
STUDY OBJECTIVES: Different therapeutic strategies have been investigated for the treatment of positional obstructive sleep apnea, but more evidence is needed about efficacy and compliance. The objective of this study was to describe the efficacy of vibrotactile neck-based treatment in patients with positional obstructive sleep apnea with different degrees of obstructive sleep apnea severity who were followed for 6 months. METHODS: This is a retrospective study including 162 patients with positional obstructive sleep apnea undergoing vibrotactile neck-based positional therapy. We compared polysomnographic data obtained at baseline and during positional therapy after 1 month. We performed a subgroup analysis based on obstructive sleep apnea severity. Furthermore, we analyzed follow-up data in 84/162 (51.8%) patients with particular focus on discontinuation and complications related to the device. RESULTS: We observed a significant difference between mean baseline obstructive apnea-hypopnea index (OAHI; 21.9 ± 9.9 events/h) and during positional therapy (12 ± 9.2 events/h; P < .01). Moreover, 87/162 (54.9%) patients showed a reduced baseline OAHI of at least 50% and 38/162 (23.4%) achieved complete disease control (OAHI < 5 events/h). At subgroup analysis, at least 50% reduction from baseline OAHI was observed in 56.8% of patients with mild, 55% with moderate, and 47.4% with severe OAHI, whereas complete control of disease was achieved in 50% of patients with mild, 22.5% with moderate, and 7.9% with severe OAHI. At a 6-month follow-up, only 35/84 patients (41.6%) were regularly using the device, with a mean of 5.9 ± 1.2 days per week. CONCLUSIONS: Our results on the efficacy and long-term adherence to vibrotactile neck-based positional therapy showed that positional therapy can be an efficient first-line treatment option for mild positional obstructive sleep apnea and in selected cases of moderate disease. Long-term compliance is limited because of complications and low satisfaction in some patients. CITATION: De Corso E, Mastrapasqua RF, Fiorita A, et al. Efficacy and long-term follow-up of positional therapy by vibrotactile neck-based device in the management of positional OSA. J Clin Sleep Med. 2020;16(10):1711–1719.
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- 2020
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38. Chaos in one-dimensional structural mechanics
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Valeria Settimi, Giuseppe Rega, and Stefano Lenci
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Structural mechanics ,Computer science ,Management science ,Applied Mathematics ,Mechanical Engineering ,Structural system ,Aerospace Engineering ,Ocean Engineering ,01 natural sciences ,Mechanical system ,Nonlinear system ,Control and Systems Engineering ,Framing (construction) ,0103 physical sciences ,Electrical and Electronic Engineering ,010301 acoustics - Abstract
Notwithstanding the presence of some books summarizing specific research bodies on structural systems, reviews on nonlinear dynamics and chaos in mechanical systems and structures are quite few. This paper aims at giving a first contribution in this direction, focusing on chaos in one-dimensional structural mechanics, and reviewing fundamental studies and main outcomes obtained for macromechanical systems and applications in classical areas of mechanical, aeronautical and civil engineering. Research material is presented according to a tentatively comprehensive perspective, by suitably framing the overviewed complex dynamic phenomena of a given class of structures within the underlying continuous/reduced modelling context and the regular phenomena from which they ensue. This is a demanding perspective, which also entails leaving a number of important topics aside. Chaos in cable, beam/arch, and coupled cable-beam structures is reviewed, as highlighted in both engineering-oriented studies and theoretically driven ones, paying attention also to some relevant applications.
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- 2020
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39. The PaCO2/FiO2 ratio as outcome predictor in SARS-COV-2 related pneumonia: a retrospective study
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Stefano, De Vuono, Pasquale, Cianci, Sokol, Berisha, Patrizia, Pierini, Gaia, Baccarini, Francesco, Balducci, Alessandra, Lignani, Laura, Settimi, Maria Rita, Taliani, and Paolo, Groff
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Male ,Aged, 80 and over ,Oxygen ,SARS-CoV-2 ,Humans ,COVID-19 ,Female ,Pneumonia ,Middle Aged ,Carbon Dioxide ,Respiratory Insufficiency ,Aged ,Retrospective Studies - Abstract
Respiratory failure in SARS-CoV-2 patients is characterized by the presence of hypoxemia and hypocapnia without relevant dyspnea. To date, the use of respiratory parameters other than PaO2/FiO2 ratio to stratify the risk of worsening of these patients has not been sufficiently studied. Aim of this work was to evaluate whether the ratio between partial pressure levels of carbon dioxide (PaCO2) and the fraction of inspired oxygen (FiO2) measured at emergency department (ED) admission is predictive of the clinical course of patients suffering from SARS-CoV-2 pneumonia.We retrospectively studied 236 patients with SARS-CoV-2 pneumonia evaluated at the ED of the Perugia Hospital. The end-points were: in-hospital mortality, need for invasive mechanical ventilation (IMV) and length of in-hospital stay (LOS). Clinical, blood gas and laboratory data were collected at ED admission.Of the 236 patients 157 were male, the mean age was 64 ± 16. Thirtythree patients (14%) needed IMV, 49 died (21%). In the univariate analysis, the PaCO2/FiO2 ratio was inversely associated with the need for IMV (p0.001), mortality (p0.001) and LOS (p = 0.005). At the multivariate analysis the PaCO2/FiO2 ratio was found to be predictive of the need for IMV, independently from age, gender, number of comorbidities, neutrophils, lymphocytes, glomerular filtrate, d-dimer, LDH and CRP.the PaCO2/FiO2 ratio is predictive of the risk of respiratory failure worsening in patients with SARS-CoV-2 pneumonia, independently from other several confounding factors.
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- 2022
40. Optimizing Pulmonary Outcomes After Total Laryngectomy: Crossover Study on New Heat and Moisture Exchangers
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Ylenia Longobardi, Jacopo Galli, Tiziana Di Cesare, Lucia D’Alatri, Stefano Settimi, Dario Mele, Francesco Bussu, and Claudio Parrilla
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Male ,Cross-Over Studies ,Hot Temperature ,Humidity ,Laryngectomy ,Otorhinolaryngology ,Cough ,Quality of Life ,Humans ,Surgery ,Female ,Settore MED/31 - OTORINOLARINGOIATRIA ,Prospective Studies ,devices - Abstract
To evaluate the effects of new devices-heat and moisture exchangers (HMEs) and adhesives-on pulmonary symptoms, subject adherence, quality of life, dermatologic symptoms, and patient satisfaction after laryngectomy.Prospective crossover study.Between December 2020 and April 2021, 40 patients were enrolled who had undergone laryngectomy, routinely used HMEs and adhesive, and were followed in our Department of Otolaryngology-Head and Neck Surgery.Patients were allocated into group A (new products) or group B (usual care) for 6 weeks. Then the 2 groups reversed, and each patient acted as his or her own control. Patients kept a diary and cough tally sheet. At baseline and after each 6-week period, 2 questionnaires were administered: EQ-5D (European Quality of Life-5 Dimensions) and CASA-Q (Cough and Sputum Assessment Questionnaire).Six weeks of using new products resulted in the following effects for both groups: (1) a significant reduction in daily forced expectoration and dry coughs, (2) a significant improvement in all domains of the CASA-Q, (3) an increase in adherence to HME use, (4) a significant reduction in shortness of breath and skin irritation, and (5) significantly better scores in the anxiety/depression domain of the EQ-5D.Achieving this reduction in patients who were already highly adherent to HME use is clinically relevant and underscores the importance of using better-performing HMEs that can compensate for the humidification deficit. Improving pulmonary symptomatology could reduce patient restrictions in daily life and avoidance of social activity, with a consequent positive effect on quality of life.
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- 2022
41. The evaluation of global cognitive and emotional status of older patients with chronic tinnitus
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Camillo Marra, Stefano Settimi, Tiziana Di Cesare, Anna Rita Fetoni, Rita Malesci, B Sergi, Eugenio De Corso, Gaetano Paludetti, Giorgia Rossi, Fetoni, Anna Rita, Di Cesare, Tiziana, Settimi, Stefano, Sergi, Bruno, Rossi, Giorgia, Malesci, Rita, Marra, Camillo, Paludetti, Gaetano, and De Corso, Eugenio
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medicine.medical_specialty ,Chronic tinnitus ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Anxiety ,Audiology ,Hospital Anxiety and Depression Scale ,psychiatric disorder ,Behavioral Neuroscience ,older patient ,Cognition ,Older patients ,Quality of life ,otorhinolaryngologic diseases ,medicine ,Humans ,tinnitus ,Original Research ,Aged ,cognitive impairment ,Aged, 80 and over ,Absolute threshold of hearing ,business.industry ,Middle Aged ,Anxiety Disorders ,older patients ,Settore MED/26 - NEUROLOGIA ,psychiatric disorders ,Quality of Life ,Female ,medicine.symptom ,business ,Anxiety Disorder ,Tinnitus ,tinnitu ,Human ,RC321-571 - Abstract
Objectives Tinnitus is a common symptom largely impactful on quality of life, especially in the elderly. Our aim was to evaluate the efficacy of self‐administered screening tests to correlate the severity of subjective perception of tinnitus with emotional disorders and the overall cognitive status. Methods Patients aged ≥ 55 years with chronic tinnitus were recruited and submitted to a complete audiological evaluation; Tinnitus Handicap inventory (THI); Hospital Anxiety and Depression Scale (HADS‐A and HADS‐D) and Mini‐Mental State Examination (MMSE). Demographic and audiological features of patients with and without cognitive impairment (MMSE score cut‐off of 24/30) were analyzed in order to reveal the relationship among tinnitus, emotional disorders, and cognitive dysfunction. Results 102 patients were recruited (mean age: 70.4 ± 9.6). THI score was directly related to HADS‐A score (r = .63) HADS‐D score (r = .66), whereas there was no relationship between tinnitus severity and MMSE (r = .13). CI and n‐CI groups did not differ in the characteristics of tinnitus (p > .05), however, hearing threshold (p = .049) and anxious depressive traits measured with HADS‐A (p = .044) and HADS‐D (p = .016) were significantly higher in the group with cognitive impairment. Furthermore, age ≥ 75 years (p = .002, OR = 13.8), female sex (p = .032; OR = 6.5), severe hearing loss (p = .036; OR = 2.3), and anxiety (p = .029; OR = 9.2) resulted risk factors for CI. Therefore, in CI group MMSE score was inversely related to age (r = −.84). Conclusions Cognitive impairment and psychiatric discomfort should be considered in tinnitus patients, related to increasing age, female sex, and severe hearing loss. Thus, self‐administered questionnaires can be useful in addressing clinical approach., Anxious/depressive traits are higher prevalent in geriatric tinnitus patients. Risk of cognitive dysfunction increases in relation to increasing age, female sex and severe hearing loss. Aging is an independent factor for the development of cognitive dysfunction in tinnitus‐suffers as well as severe hearing loss; Self‐administered screening tests for global cognitive and emotional status are recommended in managing of older patients with tinnitus.
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- 2021
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42. EFFECT OF MULTI-PASS COLD ROLLING ON THE CORROSION PROPERTIES OF 2101 DUPLEX STAINLESS STEEL
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Pezzato, Luca, Gennari, Claudio, Settimi, ALESSIO GIORGIO, Calliari, Irene, Alexandra, Kemény, and Istvan, Mészáros
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- 2022
43. Study of the effect of plasma-activated water generated by different sources on Ca2+ signalling in Arabidopsis thaliana
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Vanni, Antoni, Cortese, Enrico, Cappellin, Luca, Dabala', Manuele, Alessandro, Fassina, Alessia, Famengo, Alessandro, Galenda, Settimi, Alessio G., and Navazio, Lorella
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- 2022
44. Plasma-activated water as a novel green priming agent for plants: unlocking Ca2+-mediated signalling mechanisms
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Cortese, Enrico, Settimi, Alessio G., Cappellin, Luca, Alessandro, Galenda, Alessia, Famengo, Dabala', Manuele, DE STEFANI, Diego, Vanni, Antoni, and Navazio, Lorella
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- 2022
45. Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A 'Real-Life' Observational Study in the First Year of Treatment
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Eugenio De Corso, Stefano Settimi, Claudio Montuori, Marco Corbò, Giulio Cesare Passali, Davide Paolo Porru, Simone Lo Verde, Camilla Spanu, Daniele Penazzi, Giuseppe Alberto Di Bella, Eleonora Nucera, Matteo Bonini, Gaetano Paludetti, and Jacopo Galli
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real life ,type-2 inflammation ,dupilumab ,Settore MED/09 - MEDICINA INTERNA ,eosinophilic otitis media ,chronic rhinosinusitis with nasal polyps ,asthma ,biologics ,eosinophils ,treatment outcomes ,General Medicine - Abstract
The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP.
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- 2022
46. Study of the Effect of Plasma-Activated Water Generated by Different Sources on Ca2+ Signalling in Arabidopsis thaliana
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Antoni V., Cortese E., Cappellin L., Dabalà M., Fassina A., Famengo A., Galenda A., Settimi A.G., and Navazio L.
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Plasma-Activated Water ,Arabidopsis Thaliana ,fungi ,food and beverages - Abstract
Increasing evidence indicates that water activated by plasma discharge, termed as plasma-activated water (PAW), can promote plant growth and enhance plant defense responses. prelinimary results of the potential involvement of calcium as intracellular messenger in the transduction of PAW by plants. To study the signalling pathways activated in plants in response to PAW , Arabidopsis thaliana seedlings stably expressing the bioluminescent Ca2+ reporter aequorin were irrigated with PAW generated by different plasma torches and by a Dielectric Barrier Discarge source. In this contribution we present characteristics of the different sources as well as preliminary results on their effect on Ca2+ . In particular the dynamics of the recorded Ca2+ signals are discussed in terms of the wide range of operational conditions of the different sources, cryogenic PAW storage and its dilution.
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- 2022
47. ANÁLISE DE RISCO DE BARRAGENS UTILIZANDO FUZZY ANALYTIC HIERARCHY PROCESS (FAHP): UM ESTUDO DE CASO APLICADO
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Flavio Augusto Settimi Sohler, José Roberto Ribas, and Friedrich Wilhelm Herms
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O objetivo deste capítulo é elaborar uma proposta de framework para a comparação de eventos de riscos para usinas hidrelétricas percebidos pelo proprietário e construtor. A ideia principal do método é utilizar a experiência de alguns técnicos selecionados pelo construtor e pelo proprietário, em prol da especificação do modelo e quantificá-lo por meio de uma técnica multicritério. Resultados: Foram definidos cinco pacotes de serviço e cinco eventos de riscos que são os mais preocupantes na visão do construtor e do proprietário. Após a aplicação das métricas para os pacotes de serviço e eventos de riscos, procedeu-se à priorização dos mesmos. Conclusão: Após as entrevistas e aplicação da técnica multicritério, observou-se que a visão de riscos do empreendimento entre o construtor e o proprietário, foi ligeiramente diferente.
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- 2022
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48. Tuning plant perception of plasma-activated water to foster a more sustainable agriculture
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Cortese, Enrico, Cappellin, Luca, Alessandro, Galenda, Alessia, Famengo, Settimi, Alessio G., Dabala', Manuele, DE STEFANI, Diego, Vanni, Antoni, and Navazio, Lorella
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- 2022
49. Quantitative analysis of cytosolic calcium signals induced in plants by water activated via two different plasma discharge devices
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Cortese, Enrico, Settimi, Alessio G., Cappellin, Luca, Alessandro, Galenda, Alessia, Famengo, Dabala', Manuele, DE STEFANI, Diego, Vanni, Antoni, and Navazio, Lorella
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- 2022
50. Laparoscopic Partial Nephrectomy in Pediatric Patients
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Ciro Esposito, Maria Escolino, Alessandra Farina, Fulvia Del Conte, Vincenzo Coppola, Mariapina Cerulo, Giuseppe Autorino, and Alessandro Settimi
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- 2022
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