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2. On a spring full moon, observations on the date of death of Arsinoe II Philadelphus

Author

Adalberto Magnelli and Giulia Senesi

Abstract

La possibile rilettura, con conseguente nuova interpretazione, di uno scholium alla ἐκθέωϲιϲ di Arsinoe di Callimaco (Fr. 228 Pfeiffer ad l.7) potrebbe consentire di formulare una nuova ipotesi sulla dibattuta data di morte della regina Arsinoe II Filadelfo, forse avvenuta durante il plenilunio fra 16 e 17 giugno del 268 a.C. Thanks to a re-interpretation of a scholium to the ἐκθέωϲιϲ of Arsinoes by Callimachus (Fr. 228 Pfeiffer ad l.7) it could be possible to put forward a new hypothesis on the date of death of Queen Arsinoe II Philadelphus, which may have occurred during the full moon between the 16th and 17th June 268 BC.

Published
2023
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3. On the representation theory of cyclic and dihedral quandles

Author

Elhamdadi, Mohamed, Senesi, Prasad, and Zappala, Emanuele

Subjects
FOS: Mathematics, 20C05, 57M05, Representation Theory (math.RT), Mathematics - Representation Theory
Abstract

Quandle representations are homomorphisms from a quandle to the group of invertible matrices on some vector space taken with the conjugation operation. We study certain families of quandle representations. More specifically, we introduce the notion of regular representation for quandles, investigating in detail the regular representations of dihedral quandles and \emph{completely classifying} them. Then, we study representations of cyclic quandles, giving some necessary conditions for irreducibility and providing a complete classification under some restrictions. Moreover, we provide various counterexamples to constructions that hold for group representations, and show to what extent such theory has the same properties of the representation theory of finite groups. In particular, we show that Maschke's theorem does not hold for quandle representations., 27 pages

Published
2023

5. Isolation of dissolved organic matter from aqueous solution by precipitation with FeCl3: mechanisms and significance in environmental perspectives

Author

Jie Zhang, Khan M. G. Mostofa, Xuemei Yang, Mohammad Mohinuzzaman, Cong-Qiang Liu, Nicola Senesi, Giorgio S. Senesi, Donald L. Sparks, H. Henry Teng, Longlong Li, Jie Yuan, and Si-Liang Li

Subjects
Multidisciplinary
Abstract

Ferric ions can bind strongly with dissolved organic matter (DOM), including humic acids (HA), fulvic acids (FA), and protein-like substances, whereas isolation of Fe-DOM precipitates (Fe-DOMP) and their biochemical characteristics remain unclear. In this work FeCl3 was used to isolate DOM components from various sources, including river, lake, soil, cow dung, and standard tryptophan and tyrosine, through precipitation at pH 7.5–8.5. The Fe-DOMP contribute to total DOM by approximately 38.6–93.8% of FA, 76.2% of HA and 25.0–30.4% of tryptophan and tyrosine, whilst fluorescence spectra allowed to monitor/discriminate the various DOM fractions in the samples. The relative intensity of the main infrared peaks such as 3406‒3383 cm−1 (aromatic OH), 1689‒1635 cm−1 (‒COOH), 1523–1504 cm−1 (amide) and 1176–1033 cm−1 (‒S=O) show either to decline or disappear in Fe‒DOMP. These results suggest the occurrence of Fe bonds with various functional groups of DOM, indicating the formation of π–d electron bonding systems of different strengths in Fe‒DOMP. The novel method used for isolation of Fe-DOMP shows promising in opening a new frontier both at laboratory and industrial purposes. Furthermore, results obtained may provide a better understanding of metal–organic complexes involved in the regulation of the long-term stabilization/sequestration of DOM in soils and waters.

Published
2023
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6. Safety of COVID-19 Vaccines Among the Paediatric Population: Analysis of the European Surveillance Systems and Pivotal Clinical Trials

Author

Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P. W., Bucsa C., Osman A., Liddiard M., Maques F. B., Petrelli G., Sonderlichova S., Thurin N. H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L. A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P. M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M. P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A. M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M. S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M. A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., Mastropasqua D., Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P.W., Bucsa C., Osman A., Liddiard M., Maques F.B., Petrelli G., Sonderlichova S., Thurin N.H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L.A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P.M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M.P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A.M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M.S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M.A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., and Mastropasqua D.

Subjects
COVID-19 Vaccines, safety, Surveillance Systems, Pivotal Clinical Trials
Abstract

Background and Objectives: The European Medicine Agency extended the use of Comirnaty, Spikevax, and Nuvaxovid in paediatrics; thus, these vaccines require additional real-world safety evidence. Herein, we aimed to monitor the safety of COVID-19 vaccines through Covid-19 Vaccine Monitor (CVM) and EudraVigilance surveillance systems and the published pivotal clinical trials. Methods: In a prospective cohort of vaccinees aged between 5 and 17 years, we measured the frequency of commonly reported (local/systemic solicited) and serious adverse drug events (ADRs) following the first and second doses of COVID-19 vaccines in Europe using data from the CVM cohort until April 2022. The results of previous pivotal clinical trials and data in the EudraVigilance were also analysed. Results: The CVM study enrolled 658 first-dose vaccinees (children aged 5–11 years; n = 250 and adolescents aged 12–17 years; n = 408). Local/systemic solicited ADRs were common, whereas serious ADRs were uncommon. Among Comirnaty first and second dose recipients, 28.8% and 17.1% of children and 54.2% and 52.2% of adolescents experienced at least one ADR, respectively; injection-site pain (29.2% and 20.7%), fatigue (16.1% and 12.8%), and headache (22.1% and 19.3%) were the most frequent local and systemic ADRs. Results were consistent but slightly lower than in pivotal clinical trials. Reporting rates in Eudravigilance were lower by a factor of 1000. Conclusions: The CVM study showed high frequencies of local solicited reactions after vaccination but lower rates than in pivotal clinical trials. Injection-site pain, fatigue, and headache were the most commonly reported ADRs for clinical trials, but higher than spontaneously reported data.

Published
2023

7. Large-Scale Postmarketing Surveillance of Biological Drugs for Immune-Mediated Inflammatory Diseases Through an Italian Distributed Multi-Database Healthcare Network: The VALORE Project

Author

Trifiro, G., Isgro, V., Ingrasciotta, Y., Ientile, V., L'Abbate, L., Foti, S. S., Belleudi, V., Poggi, F., Fontana, A., Moretti, U., Lora, R., Sabaini, A., Senesi, I., Sorrentino, C., Puzo, M. R., Padula, A., Fusco, M., Giordana, R., Solfrini, V., Puccini, A., Rossi, P., Del Zotto, S., Leoni, O., Zanforlini, M., Ancona, D., Bavaro, V., Garau, D., Ledda, S., Scondotto, S., Allotta, A., Tuccori, M., Gini, R., Bucaneve, G., Franchini, D., Cavazzana, A., Biasi, V., Spila Alegiani, S., Massari, M., Andretta, I., Tanaglia, M., Carriero, A., Sassano, S., De Sarro, G., Mirarchi, S., Palleria, C., Sarro, C., Balestrieri, M., Rostan, S., Capuano, A., Bernardi, F. F., Trama, U., Russo, A., Fumo, M. G., Addis, A., Musicco, F., Sapigni, E., Mazzetti, I., Podetti, D., Potenza, A. M., Nikitina, V., Ricciardelli, R., Mogheiseh, N., Croce, S., Pettinelli, A., Ejlli, L., Fortino, I., Ercolanoni, M., Mazzone, A., Nisic, A., Schiatti, S., Ludergnani, M., Mancini, M., Patregnani, L., Fabbietti, P., Antonicelli, E., Mangano, A., Campomori, A., Urru, S. A., Costa, G., Guarrera, G. M., Stella, P., Serra, E., Carta, P., Vannacci, A., Lucenteforte, E., Parrilli, M., Convertino, I., De Giorgi, M., Rocchi, R. E., Rossi, M., Scroccaro, G., Deambrosis, P., Grindelli, G., Ferroni, E., Trifiro, G., Isgro, V., Ingrasciotta, Y., Ientile, V., L'Abbate, L., Foti, S. S., Belleudi, V., Poggi, F., Fontana, A., Moretti, U., Lora, R., Sabaini, A., Senesi, I., Sorrentino, C., Puzo, M. R., Padula, A., Fusco, M., Giordana, R., Solfrini, V., Puccini, A., Rossi, P., Del Zotto, S., Leoni, O., Zanforlini, M., Ancona, D., Bavaro, V., Garau, D., Ledda, S., Scondotto, S., Allotta, A., Tuccori, M., Gini, R., Bucaneve, G., Franchini, D., Cavazzana, A., Biasi, V., Spila Alegiani, S., Massari, M., Andretta, I., Tanaglia, M., Carriero, A., Sassano, S., De Sarro, G., Mirarchi, S., Palleria, C., Sarro, C., Balestrieri, M., Rostan, S., Capuano, A., Bernardi, F. F., Trama, U., Russo, A., Fumo, M. G., Addis, A., Musicco, F., Sapigni, E., Mazzetti, I., Podetti, D., Potenza, A. M., Nikitina, V., Ricciardelli, R., Mogheiseh, N., Croce, S., Pettinelli, A., Ejlli, L., Fortino, I., Ercolanoni, M., Mazzone, A., Nisic, A., Schiatti, S., Ludergnani, M., Mancini, M., Patregnani, L., Fabbietti, P., Antonicelli, E., Mangano, A., Campomori, A., Urru, S. A., Costa, G., Guarrera, G. M., Stella, P., Serra, E., Carta, P., Vannacci, A., Lucenteforte, E., Parrilli, M., Convertino, I., De Giorgi, M., Rocchi, R. E., Rossi, M., Scroccaro, G., Deambrosis, P., Grindelli, G., and Ferroni, E.

Subjects
Male, medicine.medical_specialty, Population, Postmarketing surveillance, Rate ratio, REGISTRIES, Retrospective Studie, Internal medicine, BIOSIMILARS, medicine, Adalimumab, Humans, Pharmacology (medical), Original Research Article, education, Adverse effect, ANTI-TNF THERAPY, RHEUMATOID-ARTHRITIS, RISK, PHARMACOVIGILANCE, BIOSIMILARS, EXPERIENCE, REGISTRIES, PSORIASIS, MEDICINES, ACCESS, Biosimilar Pharmaceuticals, Retrospective Studies, RISK, Delivery of Health Care, Female, Infliximab, Italy, SARS-CoV-2, COVID-19, Pharmacology, education.field_of_study, PSORIASIS, business.industry, Biosimilar, ANTI-TNF THERAPY, General Medicine, medicine.disease, RHEUMATOID-ARTHRITIS, PHARMACOVIGILANCE, MEDICINES, EXPERIENCE, Immune-mediated inflammatory diseases, ACCESS, business, Human, Biosimilar Pharmaceutical, Biotechnology, medicine.drug
Abstract

Background Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings. Objective The aim of this study was to explore the potential of a large Italian multi-database distributed network for use in the postmarketing surveillance of biological drugs, including biosimilars, in patients with IMID. Methods A retrospective cohort study was conducted using 13 Italian regional claims databases during 2010–2019. A tailor-made R-based tool developed for distributed analysis of claims data using a study-specific common data model was customized for this study. We measured the yearly prevalence of biological drug users and the frequency of switches between originator and biosimilars for infliximab, etanercept, and adalimumab separately and stratified them by calendar year and region. We then calculated the cumulative number of users and person-years (PYs) of exposure to individual biological drugs approved for IMIDs. For a number of safety outcomes (e.g., severe acute respiratory syndrome coronavirus 2 [SARS-COV-2] infection), we conducted a sample power calculation to estimate the PYs of exposure required to investigate their association with individual biological drugs approved for IMIDs, considering different strengths of association. Results From a total underlying population of almost 50 million inhabitants from 13 Italian regions, we identified 143,602 (0.3%) biological drug users, with a cumulative exposure of 507,745 PYs during the entire follow-up. The mean age ± standard deviation of biological drug users was 49.3 ± 16.3, with a female-to-male ratio of 1.2. The age-adjusted yearly prevalence of biological drug users increased threefold from 0.7 per 1000 in 2010 to 2.1 per 1000 in 2019. Overall, we identified 40,996 users of biosimilars of tumor necrosis factor (TNF)-α inhibitors (i.e., etanercept, adalimumab, and infliximab) in the years 2015–2019. Of these, 46% (N = 18,845) switched at any time between originator and biosimilars or vice versa. To investigate a moderate association (incidence rate ratio 2) between biological drugs approved for IMIDs and safety events of interest, such as optic neuritis (lowest background incidence rate 10.4/100,000 PYs) or severe infection (highest background incidence rate 4312/100,000 PYs), a total of 43,311 PYs and 104 PYs of exposure to individual biological drugs, respectively, would be required. As such, using this network, of 15 individual biological drugs approved for IMIDs, the association with those adverse events could be investigated for four (27%) and 14 (93%), respectively. Conclusion The VALORE project multi-database network has access to data on more than 140,000 biological drug users (and > 0.5 million PYs) from 13 Italian regions during the years 2010–2019, which will be further expanded with the inclusion of data from other regions and more recent calendar years. Overall, the cumulated amount of person-time of exposure to biological drugs approved for IMIDs provides enough statistical power to investigate weak/moderate associations of almost all individual compounds and the most relevant safety outcomes. Moreover, this network may offer the opportunity to investigate the interchangeability of originator and biosimilars of several TNFα inhibitors in different therapeutic areas in real-world settings. Supplementary Information The online version contains supplementary material available at 10.1007/s40259-021-00498-3.

Published
2021
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8. Mason type III fractures of the radial head: ORIF, resection or prosthetic replacement?

Author

D. Scoscina, G. Facco, P. Luciani, N. Setaro, L. Senesi, M. Martiniani, and A. P. Gigante

Subjects
Orthopedics and Sports Medicine, Surgery
Abstract

Purpose This study focused on a comparison of mid-term clinical, functional and radiographic outcomes of adults treated by open reduction and internal fixation (ORIF), radial head prosthesis (RHP) and resection (RHR). Methods The retrospective evaluation concerned 47 surgically treated patients after a mean follow-up of 53 months. All patients were grouped according to the surgical procedure performed: 15 in the RHP group, 16 in the ORIF group and 16 in the RHR group. At the follow-up, outcome assessment was based on radiographs, range of motion (ROM) and functional rating scores. Results Patients treated by RHR had significantly higher mean age and shorter operation time than other two groups. Compared to ROM, flexion, extension and pronation were significantly worse in patients treated by ORIF than those in the RHP group and the RHR group. Supination was significantly better in the RHP group. However, no statistical differences were observed in functional rating scores among the three groups. Regarding complications, instability was the only cause of revision surgery in the RHP group and the RHR group. On the other hand, the ORIF group revision rate was 50% and secondary displacement was the most frequent cause of failure. Conclusion The ORIF group did not show good results with greater elbow stiffness and higher revision rate than the other two techniques. RHR may be suitable for elderly patients with lower functional demands as it reported good clinical results and reduced operation time.

Published
2022
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9. Hydrogen Detection Limits and Instrument Sensitivity of High-Resolution Broadband Neutron Spectrometers

Author

Claudia Scatigno, Matteo Zanetti, Svemir Rudić, Roberto Senesi, Carla Andreani, Giuseppe Gorini, Felix Fernandez-Alonso, Science and Technology Facilities Council (UK), Consiglio Nazionale delle Ricerche, Eusko Jaurlaritza, Agencia Estatal de Investigación (España), and Ministerio de Ciencia, Innovación y Universidades (España)

Subjects
Neutrons, Settore FIS/03, Spectrometers, Limit of Detection, Spectrum Analysis, Calibration, Neutron scattering, Nuclear Experiment, Hydrogen, Analytical Chemistry
Abstract

The limits of detection (LOD) and quantitation (LOQ) in the mass domain, for broadband vibrational spectroscopy with neutrons on the TOSCA spectrometer at the ISIS Pulsed Neutron and Muon Source (UK), have been studied. The well-known 3σ and 10σ approaches are used through a specifically developed analytical procedure that is based on the calculation of the integrated spectral intensities in selected energy-transfer ranges, as a function of mass of standard reference materials and calibrants, such as ZrH2, 2,5-diiodothiophene, and low-density polyethylene. The analysis shows that the blank, that is, the instrument setup without the analyte, plays a critical role in the measurement performance, especially for small specimen quantities. The results point that TOSCA enables detection of 128 μmol (LODH) and quantitation of 428 μmol (LOQH) of elemental hydrogen analytes in ZrH2. The determined values for this and other standards allow for the assessment of the calibration curve design and instrument sensitivity and define a method to be used for inelastic neutron scattering spectrometers such as TOSCA, or VESPA, the new beamline under construction at the European Spallation Source in Lund (Sweden)., The authors gratefully acknowledge the Science and Technology Facilities Council (STFC) for financial support for this project. The work has been partially supported by Consiglio Nazionale delle Ricerche (CNR) within the 2014–2020 CNR-STFC Agreement (N. 3420) concerning collaboration in scientific research at the ISIS Facility and by ESS-ERIC for Instrument VESPA Phase 1. Financial support from the Basque Government and the Spanish Ministry of Science and Innovation under Grant Numbers PIBA-2021-0026 and PID2020-114506GB-I00 is gratefully acknowledged.

Published
2022
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10. Handheld Laser-Induced Breakdown Spectroscopy (hLIBS): A Valuable Tool for Terrestrial and Extraterrestrial Recognition of Meteorites in the Field

Author

Giorgio S. Senesi

Subjects
Spectroscopy, Atomic and Molecular Physics, and Optics, Analytical Chemistry
Abstract

The role and performance of handheld laser-induced breakdown spectroscopy (hLIBS) devices is discussed in the context of meteorite research exploration while targeting specific questions of geologic interest in the field. The fast data acquisition and minimal sample preparation features of these devices make them very attractive as candidate tools for future astronauts in geochemical mapping, resource prospecting, sample selection, and hazard identification. Although hLIBS instruments have recently become commercially available, they have not yet been widely applied to meteoritical field campaign. This article reviews how the very promising advanced analytical tool hLIBS may be helpful to classify and discriminate meteorites in the field.

Published
2022
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12. Characterization of Conductive Carbon Nanotubes/Polymer Composites for Stretchable Sensors and Transducers

Author

Laura Fazi, Carla Andreani, Cadia D’Ottavi, Leonardo Duranti, Pietro Morales, Enrico Preziosi, Anna Prioriello, Giovanni Romanelli, Valerio Scacco, Roberto Senesi, and Silvia Licoccia

Subjects
carbon nanotubes, polymer composites, Settore FIS/07, Organic Chemistry, stretchable sensors, Settore CHIM/07, Pharmaceutical Science, self-assembly, Analytical Chemistry, Chemistry (miscellaneous), Drug Discovery, stretchable conductors, Molecular Medicine, Physical and Theoretical Chemistry
Abstract

The increasing interest in stretchable conductive composite materials, that can be versatile and suitable for wide-ranging application, has sparked a growing demand for studies of scalable fabrication techniques and specifically tailored geometries. Thanks to the combination of the conductivity and robustness of carbon nanotube (CNT) materials with the viscoelastic properties of polymer films, in particular their stretchability, “surface composites” made of a CNT on polymeric films are a promising way to obtain a low-cost, conductive, elastic, moldable, and patternable material. The use of polymers selected for specific applications, however, requires targeted studies to deeply understand the interface interactions between a CNT and the surface of such polymer films, and in particular the stability and durability of a CNT grafting onto the polymer itself. Here, we present an investigation of the interface properties for a selected group of polymer film substrates with different viscoelastic properties by means of a series of different and complementary experimental techniques. Specifically, we studied the interaction of a single-wall carbon nanotube (SWCNT) deposited on two couples of different polymeric substrates, each one chosen as representative of thermoplastic polymers (i.e., low-density polyethylene (LDPE) and polypropylene (PP)) and thermosetting elastomers (i.e., polyisoprene (PI) and polydimethylsiloxane (PDMS)), respectively. Our results demonstrate that the characteristics of the interface significantly differ for the two classes of polymers with a deeper penetration (up to about 100 μm) into the polymer bulk for the thermosetting substrates. Consequently, the resistance per unit length varies in different ranges, from 1–10 kΩ/cm for typical thermoplastic composite devices (30 μm thick and 2 mm wide) to 0.5–3 MΩ/cm for typical thermosetting elastomer devices (150 μm thick and 2 mm wide). For these reasons, the composites show the different mechanical and electrical responses, therefore suggesting different areas of application of the devices based on such materials.

Published
2023
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13. The Gamma-Flash data acquisition system for observation of terrestrial gamma-ray flashes

Author

Bulgarelli, Andrea, Addis, Antonio, Aboudan, Alessio, Abu, Ismael, Andreani, Carla, Argan, Andrea, Campana, Riccardo, Calabretto, Paolo, Pittori, Carlotta, D'Amico, Fabio, Donnarumma, Imma, De Rosa, Adriano, Fuschino, Fabio, Gorini, Giuseppe, Levi, Giuseppe, Parmiggiani, Nicolò, Picozza, Piergiorgio, Polenta, Gianluca, Preziosi, Enrico, Senesi, Roberto, Ursi, Alessandro, Vagelli, Valerio, and Virgilli, Enrico

Subjects
FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

Gamma-Flash is an Italian project funded by the Italian Space Agency (ASI) and led by the National Institute for Astrophysics (INAF), devoted to the observation and study of high-energy phenomena, such as terrestrial gamma-ray flashes and gamma-ray glows produced in the Earth's atmosphere during thunderstorms. The project's detectors and the data acquisition and control system (DACS) are placed at the "O. Vittori" observatory on the top of Mt. Cimone (Italy). Another payload will be placed on an aircraft for observations of thunderstorms in the air. This work presents the architecture of the data acquisition and control system and the data flow., 4 pages, 1 figure, Astronomical Data Analysis Software and System XXXII (2022)

Published
2023

14. Diagnostic performance of CSF biomarkers in a well-characterized Australian cohort of sporadic Creutzfeldt-Jakob disease

Author

Matteo Senesi, Victoria Lewis, Shiji Varghese, Christiane Stehmann, Amelia McGlade, James D. Doecke, Laura Ellett, Shannon Sarros, Christopher J. Fowler, Colin L. Masters, Qiao-Xin Li, and Steven J. Collins

Subjects
Neurology, Neurology (clinical)
Abstract

The most frequently utilized biomarkers to support a pre-mortem clinical diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) include concentrations of the 14-3-3 and total tau (T-tau) proteins, as well as the application of protein amplification techniques, such as the real time quaking-induced conversion (RT-QuIC) assay, in cerebrospinal fluid (CSF). Utilizing CSF from a cohort of neuropathologically confirmed (definite) sCJD (n = 50) and non-CJD controls (n = 48), we established the optimal cutpoints for the fully automated Roche Elecsys® immunoassay for T-tau and the CircuLexTM 14-3-3 Gamma ELISA and compared these to T-tau protein measured using a commercially available assay (INNOTEST hTAU Ag) and 14-3-3 protein detection by western immunoblot (WB). These CSF specimens were also assessed for presence of misfolded prion protein using the RT-QuIC assay. T-tau showed similar diagnostic performance irrespective of the assay utilized, with ~90% sensitivity and specificity. The 14-3-3 protein detection by western blot (WB) has 87.5% sensitivity and 66.7% specificity. The 14-3-3 ELISA demonstrated 81.3% sensitivity and 84.4% specificity. RT-QuIC was the single best performing assay, with a sensitivity of 92.7% and 100% specificity. Our study indicates that a combination of all three CSF biomarkers increases sensitivity and offers the best chance of case detection pre-mortem. Only a single sCJD case in our cohort was negative across the three biomarkers, emphasizing the value of autopsy brain examination on all suspected CJD cases to ensure maximal case ascertainment.

Published
2023
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16. Fast scanning calorimetry on volatile carbon-based materials

Author

Valerio Di Lisio, Balthasar Braunewell, Cristina Macia-Castello, Margherita Simoni, Roberto Senesi, Felix Fernandez-Alonso, Daniele Cangialosi, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Eusko Jaurlaritza, and Ikerbasque Basque Foundation for Science

Subjects
History, Volatile carbon-based materials, Polymers and Plastics, Differential scanning calorimetry (DSC), Sample encapsulation & preparation, Fast scanning calorimetry (FSC), Physical and Theoretical Chemistry, Business and International Management, Condensed Matter Physics, Crystallization, Instrumentation, Glass transition, Industrial and Manufacturing Engineering
Abstract

This work introduces a new sample-preparation methodology to investigate volatile materials with fast scanning calorimetry (FSC). The protocol consists of a two-step process involving the embedding of the specimen in an inert silicone-oil-based matrix followed by gold sputtering, in order to ensure full encapsulation and isolation from the surrounding environment. This novel approach is tested thoroughly on a series of three carbon-based materials – resorcinol, corannulene and perylene. In addition to establishing the validity of our methodology, the FSC data also gives access to new and hitherto unexplored regimes of thermodynamic stability and metastability in these materials, including the emergence of glassy states, cold crystallization, and solid-to-solid transformations., Financial support for this work has been secured through Grants PID2020-114506GB-I00 funded by MCIN/AEI/10.13039/501100011033; TED2021-129457B-I00 funded by MCIN/AEI /10.13039/501100011033 and the European Union NextGenerationEU/PRTR; PIBA-2021-0026 and EC-2022-1-0019, funded by the Basque Government. B.B. thanks the Basque Government for a PREDOC-BERRI Ph.D. fellowship. We also acknowledge the financial support received from the IKUR Strategy under the collaboration agreement between Ikerbasque Foundation and the Materials Physics Center on behalf of the Department of Education of the Basque Government.

Published
2023

17. Infecção do trato urinário na gestação: contexto social e características clínicas

Author

Rosália Rubel, Otília Beatriz Maciel da Silva, Fernanda Pereira Lopes Grein, Mario Augusto Muggiati, Renan Ishikawa Salomão, Denise Jorge Munhoz da Rocha, and Lenira Gaede Senesi

Subjects
General Medicine
Abstract

Um dos Objetivos de Desenvolvimento do Milênio (ODM) estabelecidos pela ORGANIZAÇÃO DAS NAÇÕES UNIDAS em 2015 é reduzir a mortalidade materna, até 2030, para 30 óbitos para cada 100 mil nascidos vivos. Infecções do trato urinário (ITU) na gestação estão entre as principais causas de complicações e frequentemente cursam para o agravamento do quadro clínico materno-infantil. Conhecer o contexto social e as características clínico-laboratoriais das gestantes com ITU é importante para a elaboração de protocolos de cuidado diferenciados e para o sucesso terapêutico. Método: A presente pesquisa delineou o perfil sociodemográfico, epidemiológico e clínico-laboratorial de gestantes internadas em uma maternidade pública de baixo risco, para tratamento de ITU, através da análise documental de 95 prontuários, no período de janeiro a dezembro de 2019. Resultados: As pacientes adolescentes (entre 15 e 19 anos) foram 24,21% do total, enquanto 71,58% tinham entre 20 e 34 anos. Pacientes que não concluíram o primeiro grau foram 17%, aquelas que ultrapassaram o segundo grau foram 39%. Apenas 2,11% tinham curso superior completo. Gestantes primigestas foram 28,42% dos casos. A maioria das gestantes (91,58%) estava no segundo (45,26%) e no terceiro (46,32%) trimestres. O tempo médio de internação foi entre três e oito dias. Mais da metade das mulheres (51,57%) precisou de mais de uma internação hospitalar, sendo que dessas, 37,89% estavam na segunda e 13,68% na terceira internação, pelo mesmo motivo. O desfecho clínico majoritário foi parto vaginal (48,4%), seguido de parto cesáreo (13,7%). Destaca-se o histórico de infecção do trato urinário recorrente em 43% das mulheres. Conclusão: Os resultados obtidos serão úteis para fundamentar outras pesquisas e para a elaboração de protocolos institucionais com o intuito de monitorar as gestantes com infecção urinária, desde a consulta inicial na Unidade Básica de Saúde até o desfecho final na maternidade, mapeando os principais fatores de risco.

Published
2021
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18. Ultralow Power System-on-Chip SRAM Characterization by Alpha and Neutron Irradiation

Author

Eran Mazal-Tov, Roberto Senesi, Christopher D. Frost, Eitan Keren, Carla Andreani, Enrico Preziosi, Nir M. Yitzhak, Tzach Hadas, Uzi Zangi, Carlo Cazzaniga, A. Haran, D. David, and Nati Refaeli

Subjects
Nuclear and High Energy Physics, subthreshold voltage, Radiation effects, Single event upsets, system-on-chip (SoC), Hardware_PERFORMANCEANDRELIABILITY, multiple bit upset (MBU), Atmospheric measurements, Upset, Electric power system, Gate array, Sea measurements, Hardware_INTEGRATEDCIRCUITS, single-event upset (SEU), Static random-access memory, Hardware_ARITHMETICANDLOGICSTRUCTURES, Electrical and Electronic Engineering, neutron irradiation, Field-programmable gate array, Alpha particles, Neutrons, Physics, Semiconductor device measurement, static random access memory (SRAM), Hardware_MEMORYSTRUCTURES, business.industry, Subthreshold conduction, Settore FIS/07, Electrical engineering, Random access memory, Nuclear Energy and Engineering, Node (circuits), business, Voltage
Abstract

The static random access memory (SRAM) of an ultralow power system-on-chip (SoC) was tested for single-event upsets (SEUs) using alpha particles and neutron beam sources. The measurements are compared to those of an SRAM-based field-programmable gate array (FPGA), built on a similar technology node. The results reveal opposite trends in the two devices regarding the upsets of the logic states, as well as differences in the dependence of SEU cross section (CS) on the operation voltage. The sensitivity of the SoC SRAM to multiple bit upsets with the different radiation sources is analyzed as well. The results demonstrate that the unique SoC design, which enables complete near/subthreshold operation, does not compromise the SoC bit upset tolerance compared to devices of similar technology node which operate at higher voltages.

Published
2021
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20. Eating Habits and Body Weight Changes Induced by Variation in Smell and Taste in Patients with Previous SARS-CoV-2 Infection

Author

Anna Ferrulli, Pamela Senesi, Ileana Terruzzi, and Livio Luzi

Subjects
Smell, Taste Disorders, Nutrition and Dietetics, SARS-CoV-2, Taste, Body Weight, Humans, COVID-19, Feeding Behavior, Pandemics, Food Science
Abstract

Olfactory and gustatory dysfunction are recognized as common symptoms in patients with COVID-19, with a prevalence ranging, respectively, between 41–61% and 38.2–49%. This review focused on relating the variations in dietary habits with the reduction/loss of smell and/or taste in patients who contracted the COVID-19 infection. Primarily, we reviewed the main pathological mechanisms involved in COVID 19-induced anosmia/dysosmia and ageusia/dysgeusia. Then, we explored and summarized the behavioural changes in food intake and body weight during the COVID-19 pandemic in relation to sensory impairment and the underlying mechanisms. Most studies on this topic argue that the altered chemosensory perception (taste and smell) mainly induces reduced appetite, leading to a faster fullness sensation during the consumption of a meal and, therefore, to a decrease in body weight. On the other hand, a reduced perception of the food’s sensory properties may trigger compensatory responses that lead some individuals to increase food intake with a different effect on body weight. Regarding body weight, most studies evaluated malnutrition in patients hospitalized for COVID-19; more studies are warranted to investigate nutritional status specifically in non-hospitalized patients with olfactory and gustatory dysfunctions caused by COVID-19 infection.

Published
2022

21. Plasma-derived extracellular vesicles released after endurance exercise exert cardioprotective activity through the activation of antioxidant pathways

Author

Veronica Lisi, Giorgia Senesi, Nadia Bertola, Matteo Pecoraro, Sara Bolis, Alice Gualerzi, Silvia Picciolini, Andrea Raimondi, Cristina Fantini, Elisa Moretti, Attilio Parisi, Paolo Sgrò, Luigi Di Luigi, Roger Geiger, Silvia Ravera, Giuseppe Vassalli, Daniela Caporossi, and Carolina Balbi

Subjects
Organic Chemistry, Clinical Biochemistry, Biochemistry
Published
2023
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22. Multidimensional prognostic index (MPI) predicts successful application for disability social benefits in older people

Author

C. Prete, Alberto Pilotto, Giacomo Siri, Roberto Sulpasso, Nicola Veronese, Alessandra Pinna, Angela Giorgeschi, Carlo Sabbà, Barbara Senesi, Senesi, B., Prete, C., Siri, G., Pinna, A., Giorgeschi, A., Veronese, N., Sulpasso, R., Sabbà, C., and Pilotto, A.

Subjects
Gerontology, Aging, Index (economics), Social benefits, Geriatric assessment, Indemnity, Prognosis, Social Security, Social security, 03 medical and health sciences, 0302 clinical medicine, Disability, Geriatric assessment, Multidimensional prognostic index, Disability benefts, Disability benefits, Humans, Disabled Persons, 030212 general & internal medicine, Geriatrics and Gerontology, Attendance Allowance, Psychology, Older people, Geriatric Assessment, 030217 neurology & neurosurgery, Aged
Abstract

Aim: The economic recognition of disability is of importance in daily practice, but the tools used in older people are still limited. Therefore, we aimed to investigate the effectiveness of the multidimensional prognostic index (MPI) to identify frail older subjects to be submitted to civil invalidity application for disability benefits including Attendance Allowance (AA) indemnity, Carer’s Leave (Law 104) and/or Parking Card for people with disabilities. Methods: From March 2018 to January 2019, 80 older people were included. The MPI was calculated from comprehensive geriatric assessment information including eight different domains. Civil benefits included attendance allowance (AA) indemnity by the Local Medico-Legal Committee (MLC-NHS) and by the National Institute of Social Security Committee (INPS), Carer’s Leave (Law 104), and Parking Card for people with disabilities. Results: MPI values were associated with an increased probability to obtain a 100% civil disability, AA indemnity, Carer’s Leave and a parking card for people with disabilities. MPI score showed a very good accuracy in predicting the civil invalidity benefits with a area-under-curve (AUC) of 87.3 (95% CI 80.6–97.4) to predict the release of AA indemnity, 81.3 (95% CI 68.5–91.1) to predict Care’s leave and 70.7 (95% CI 59.4–84.7) to predict the Parking Card release. Moreover, data showed that a cut-off score of MPI ≥ 0.75 could identify the 100% of older subjects who successfully obtained the indemnity release. Conclusion: MPI is an excellent predictor of social benefits’ release by local and national agencies. © 2020, Springer Nature Switzerland AG.

Published
2020
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24. User Needs for the Development of New Methodologies and R&D Tools for Building a Railway Digital Map and for the Experimental Performance Evaluation of On-Board Subsystems

Author

Giusy Emmanuele, Massimiliano Ciaffi, Omar Garcia Crespillo, Alessandro Neri, Alessia Vennarini, Agostino Ruggeri, Juliette Marais, Susana Herranz de Andres, Jorge Ignacio Iglesias Diaz, Daniel Molina Marinas, Ricardo Campo Cascallana, Antonio Águila Martínez-Casariego, Jose Conrado Martinez Acevedo, Fabio Senesi, Salvatore Sabina, WCRR, Emmanuele, Giusy, Ciaffi, Massimiliano, Garcia Crespillo, Omar, Neri, Alessandro, Vennarini, Alessia, Ruggeri, Agostino, Marais, Juliette, Herranz de Andres, Susana, Ignacio Iglesias Diaz, Jorge, Molina Marinas, Daniel, Campo Cascallana, Ricardo, Águila Martínez-Casariego, Antonio, Conrado Martinez Acevedo, Jose, Senesi, Fabio, and Sabina, Salvatore

Published
2022

25. Camminare per ascoltare. Partiture invisibili del territorio abitato

Author

Elisabetta Senesi

Subjects
critical listening, Geography (General), Acoustic ecology, experimental theatre, Context (language use), The arts, public space, Silence, Public space, walking, GF1-900, Aesthetics, Human ecology. Anthropogeography, G1-922, Active listening, Sociology, Generative grammar
Abstract

The paper is focused on some experiences of collective soundwalks achieved by Elisabetta Senesi within her conscious Sonic Arts research (MA Dissertation 2010). Walks are mostly performed in silence at different times and unpredictable urban paths for participants. This practice, not always performed following the tradition of Acoustic Ecology, has become particularly important in recent years, and often carried by artistic fields related to the creation of environmental compositions, both generative and interactive. In this context, Senesi uses her listening walks as case studies to open up multiple perspectives of space and critical listening, as well as its auditive aesthetics to reflect upon author’s soundwalking strategies with feedback from participant’s experiences from the last six years.

Published
2021

26. A new carbon-rich ureilite from Morocco

Author

Olga De Pascale, Francesco Capitelli, Ahmed Ait Touchnt, Fouad Khiri, Giorgio S. Senesi, Lahcen Ouknine, and Abderrahmane Ibhi

Subjects
Olivine, Geochemistry, Diamond, chemistry.chemical_element, Ureilite, Pyroxene, engineering.material, Preliminary analysis, SEM-EDS, chemistry, Meteorite, North west, engineering, General Earth and Planetary Sciences, Carbon-rich, General Agricultural and Biological Sciences, Carbon, Geology, General Environmental Science
Abstract

The main objective of this study was to provide a preliminary analysis of the meteorite North West Africa (NWA) 12606 recently classified as ureilite, which was found in 2018 in Morocco, to unveil the possible presence of diamonds. The preliminary analysis of the surface of a meteorite fragment by scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and optical microscopy has shown that it mainly consisted of olivine, minor pyroxene and carbon phases possibly including carbon in the form of diamonds. The results achieved are preliminary to a further deeper study of this meteorite as the diamond origin in ureilites is still an open issue debated among the scientific community due to its significant implications for the sizes of early Solar System bodies.

Published
2021
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27. Neutron-Enhanced Information on the Laboratory Characterization of Ancient Egyptian Leathers: Hydration and Preservation Status

Author

Giovanni Romanelli, Carla Andreani, Enrico Ferraris, Christian Greco, Salima Ikram, Silvia Licoccia, Giuseppe Paladini, Stewart F. Parker, Enrico Preziosi, Roberto Senesi, Lucy Skinner, André J. Veldmeijer, Valentina Venuti, and Valentina Turina

Subjects
Deep Inelastic Neutron Scattering, cultural heritage, Egyptian leather, vibrational spectroscopy, Scanning Electron Microscopy, elemental analysis, Settore FIS/07, Settore CHIM/07, Information Systems
Abstract

The Museo Egizio’s collection contains 200 precious and unique leather artifacts belonging to different historical periods. The materials used during the tanning and curing procedures affect the chemical and elemental composition of the surface of the samples as well as their preservation status, specifically through the hydration level within the bulk. Here we provide an experimental characterization of a series of samples from Museo Egizio that document an extensive denaturation phenomenon (gelatinization), by combining non-destructive techniques including surface probes (X-ray fluorescence, Raman scattering, and scanning electron microscopy enhanced by X-ray energy spectroscopy) and neutron-based bulk techniques (inelastic and deep-inelastic neutron scattering). Results show partial dehydration of the samples in the bulk, affecting the morphology of their surface, the presence of potassium alum, and iron oxides, as well as phosphates and hydroxides related to the tanning and curing procedures. Finally, we briefly discuss the need for a versatile and adaptable software package that is capable of combining quantitative analyses with complementary techniques including morphological, elemental, and chemical composition.

Published
2022
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28. Chlorophyll Fluorescence Imaging (CFI) and Laser-Induced Breakdown Spectroscopy (LIBS) Applied to Investigate Tomato Plants Infected by the Root Knot Nematode (RKN) Meloidogyne incognita and Tobacco Plants Infected by Cymbidium Ringspot Virus

Author

Giorgio Saverio Senesi, Olga De Pascale, Bruno Spolon Marangoni, Anderson Rodrigues Lima Caires, Gustavo Nicolodelli, Vitantonio Pantaleo, and Paola Leonetti

Subjects
Radiology, Nuclear Medicine and imaging, Instrumentation, Atomic and Molecular Physics, and Optics, tomato, Meloidogyne incognita root knot nematode, tobacco, cymbidium ringspot virus, chlorophyll fluorescence imaging, laser-induced breakdown spectroscopy
Abstract

Recently, studies on climate change have highlighted the central role of photosynthetic mechanisms in the defense response of plants to abiotic and biotic stresses. Photo-sensing and photo-activation are innovative technologies applied for the early detection of plant pathogens in order to prevent the dramatic impact they may have on plants. Chlorophyll Fluorescence Imaging (CFI) and Laser-Induced Breakdown Spectroscopy (LIBS) analytical techniques can be used to evaluate the amount of chlorophyll in plants, which can be altered in the case of biotic and abiotic stresses. In this work, both techniques were applied to two pathogenic model systems, i.e., roots of susceptible tomato plants infected by Meloidogyne incognita and Nicotiana benthamiana plants infected by cymbidium ringspot virus. Experimental evidence is provided and discussed showing that specific application protocols of both methods can be used successfully for the early detection of symptoms of the pathogen attacks of Meloidogyne incognita on tomato roots and of cymbidium ringspot virus infected plants. In particular, a decrease in chlorophyll content was measured by fluorescence imaging, and an increase in Mg++ content was determined by LIBS in both the leaves and stems of infected tomato plants and the leaves of infected plants, with respect to control (non-infected) plants. Thus, the two techniques used have been shown to be able to discriminate satisfactorily between control and infected plants and to provide some insight on the underlying mechanisms of plant defenses again nematodes and viruses.

Published
2022
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29. Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

Author

Senesi, Pamela, Ferrulli, Anna, Luzi, Livio, and Terruzzi, Ileana

Subjects
Leptin, Growth Differentiation Factor 15, Cardiovascular Diseases, Endocrinology, Diabetes and Metabolism, Animals, Humans, Incretins, Ghrelin, Circadian Rhythm
Abstract

Circadian rhythm, an innate 24-h biological clock, regulates several mammalian physiological activities anticipating daily environmental variations and optimizing available energetic resources. The circadian machinery is a complex neuronal and endocrinological network primarily organized into a central clock, suprachiasmatic nucleus (SCN), and peripheral clocks. Several small molecules generate daily circadian fluctuations ensuring inter-organ communication and coordination between external stimuli, i.e., light, food, and exercise, and body metabolism. As an orchestra, this complex network can be out of tone. Circadian disruption is often associated with obesity development and, above all, with diabetes and cardiovascular disease onset. Moreover, accumulating data highlight a bidirectional relationship between circadian misalignment and cardiometabolic disease severity. Food intake abnormalities, especially timing and composition of meal, are crucial cause of circadian disruption, but evidence from preclinical and clinical studies has shown that food could represent a unique therapeutic approach to promote circadian resynchronization. In this review, we briefly summarize the structure of circadian system and discuss the role playing by different molecules [from leptin to ghrelin, incretins, fibroblast growth factor 21 (FGF-21), growth differentiation factor 15 (GDF15)] to guarantee circadian homeostasis. Based on the recent data, we discuss the innovative nutritional interventions aimed at circadian re-synchronization and, consequently, improvement of cardiometabolic health.

Published
2022
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30. GeoLIBS Bibliography

Author

Hark, Richard, Harmon, Russell, and Senesi, Giorgio

Subjects
laser-induced breakdown spectroscopy, LIBS, GeoLIBS, atomic emission spectroscopy, analysis of geological materials, geochemistry
Abstract

A regularly updated bibliographic listing of publications related to the use of laser-induced breakdown spectroscopy (LIBS) for the analysis of geological materials

Published
2022
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31. Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2021

Author

Christiane, Stehmann, Matteo, Senesi, Shannon, Sarros, Amelia, McGlade, Victoria, Lewis, Marion, Simpson, Genevieve, Klug, Catriona, McLean, Colin L, Masters, and Steven, Collins

Subjects
14-3-3 Proteins, SARS-CoV-2, Australia, COVID-19, Humans, Prospective Studies, Disease Notification, Creutzfeldt-Jakob Syndrome, Prion Diseases
Abstract

Nationwide surveillance of Creutzfeldt-Jakob disease (CJD) and other human prion diseases is performed by the Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR). National surveillance encompasses the period since 1 January 1970, with prospective surveillance occurring from 1 October 1993. Over this prospective surveillance period, considerable developments have occurred in pre-mortem diagnostics; in the delineation of new disease subtypes; and in a heightened awareness of prion diseases in healthcare settings. Surveillance practices of the ANCJDR have evolved and adapted accordingly. This report summarises the activities of the ANCJDR during 2021. Since the ANCJDR began offering diagnostic cerebrospinal fluid (CSF) 14-3-3 protein testing in Australia in September 1997, the annual number of referrals has steadily increased. In 2021, a total of 548 domestic CSF specimens were referred for 14-3-3 protein testing; 73 persons with suspected human prion disease were formally added to the national register. As of 31 December 2021, just over half of the 73 suspect case notifications (37/73) remain classified as ‘incomplete’; 17 cases were classified as ‘definite’ and 13 as ‘probable’ prion disease; six cases were excluded through either detailed clinical follow-up (two cases) or neuropathological examination (four cases). For 2021, sixty-four percent of all suspected human-prion-disease-related deaths in Australia underwent neuropathological examination. No cases of variant or iatrogenic CJD were identified. The SARS-CoV-2 pandemic did not affect prion disease surveillance outcomes in Australia.

Published
2022
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33. Reduction of impulsivity in patients receiving deep transcranial magnetic stimulation treatment for obesity

Author

Anna Ferrulli, Concetta Macrì, Federica Bellerba, Sara Gandini, Stefano Massarini, Ileana Terruzzi, Livio Luzi, and Pamela Senesi

Subjects
Leptin, Adult, medicine.medical_specialty, Impulsivity, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Medicine, Humans, Obesity, Risk factor, Deep transcranial magnetic stimulation, business.industry, Beck Depression Inventory, Middle Aged, medicine.disease, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Treatment Outcome, Psychological traits, Impulsive Behavior, Original Article, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Purpose Aims of the present study were to investigate a wide array of psychological symptoms through validated psychometric tests, before and after 5 weeks of deep Transcranial Magnetic Stimulation (dTMS) in individuals with obesity, and to identify possible relationships with neuroendocrine parameters. Methods Forty-five patients with obesity (33 F, 12 M; age 48.8 ± 9.9 years; body wt 97.6 ± 14.2 Kg; BMI 36.2 ± 4.2) were randomized into two groups: 26 received high frequency (HF) dTMS and 19 Sham stimulation for 5 weeks. At baseline and after the 5-week treatment, all patients underwent the following psychometric evaluations: Food Cravings Questionnaire-Trait (FCQ-T) and its subscales, Barratt Impulsiveness Scale-11 (BIS-11), State and Trait Anxiety Inventory (STAI-y1 and STAI-y2), and Beck Depression Inventory (BDI). Hormonal and neuroendocrine markers were assessed at the first and last dTMS session. Results By adjusting for baseline variables and treatment arms, a significant decrease in body wt and BMI was found in HF group, both with univariate (p = 0.019) and multivariate analyses (p = 0.012). Impulsivity significantly decreased in HF group, both with univariate (p = 0.031) and multivariate analyses (p = 0.011). A positive association between the impulsivity score change and the leptin level variation (p = 0.031) was found. Conclusion The decrease of impulsivity together with the BMI reduction in individuals with obesity, treated with real stimulation, suggests that impulsivity may be a risk factor for obesity. Treatment with dTMS revealed to be effective in reducing both BMI and impulsivity by enhancing inhibitory capacity of Pre-Frontal Cortex (PFC), and modulating neuroendocrine system, especially leptin.

Published
2021

34. Validation and implementation of telephone-administered version of the Multidimensional Prognostic Index (TELE-MPI) for remote monitoring of community-dwelling older adults

Author

Valeria Mastropierro, C. Prete, Martina Vigo, Barbara Senesi, Alessandra Pinna, Marcella Fama, Carlo Sabbà, Carlo Custodero, Alberto Pilotto, and Annarosa Floris

Subjects
Male, Aging, medicine.medical_specialty, Telemedicine, Index (economics), Coronavirus disease 2019 (COVID-19), Comprehensive Geriatric Assessment (CGA), Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Older patients, Multidimensional Prognostic Index, medicine, Humans, 030212 general & internal medicine, Geriatric Assessment, Pandemics, Aged, business.industry, SARS-CoV-2, Incidence (epidemiology), COVID-19, Prognosis, Confidence interval, Telephone, Ambulatory, Communicable Disease Control, Physical therapy, Original Article, Falls, Female, Independent Living, Geriatrics and Gerontology, business, Psychiatric disorders, 030217 neurology & neurosurgery
Abstract

Background During the recent lockdown measures adopted by national authorities to contain the COVID-19 pandemic, many vulnerable older patients with chronic conditions, normally followed in ambulatory setting, needed to be monitored and managed in alternative ways, including telemedicine. Aims In the framework of a telemedicine program, we aimed to validate and implement a telephone-administered version of the Multidimensional Prognostic Index (TELE-MPI) among community-dwelling older outpatients. Method From March 9 to May 11, 2020, 131 older patients (82.1 years; 74% females) were interviewed using a telephone-based survey to calculate the TELE-MPI. The standard MPI was performed face-to-face three months apart. The Bland–Altman methodology measured the agreement between the two tools. Multivariate logistic regression models were built to ascertain the prognostic value of TELE-MPI and TELE-MPI classes (low, moderate, or severe risk) on negative outcomes occurring during the lockdown period. Results Mean MPI and TELE-MPI values were 0.523 and 0.522, respectively. Lower and upper 95% limits of agreement were − 0.122 and + 0.124, respectively, with only 4.6% of observations outside the limits. Each 0.1 increase of TELE-MPI score was significantly correlated with higher incidence of psychiatric disorders [odd ratio (OR): 1.57; 95% confidence interval (CI) 1.27, 1.95] and falls (OR: 1.41; 95% CI 1.08, 1.82) in community-dwelling-older adults. Discussion TELE-MPI showed a strong agreement with the standard MPI and was able to predict psychiatric disorders and falls during lockdown period. Conclusion TELE-MPI may represent a useful way to follow by remote the health status of older adults.

Published
2021

35. Complications of proximal humeral fractures

Author

Letizia Senesi, A. Maresca, R. Pascarella, and Simone Cerbasi

Subjects
030222 orthopedics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Nonunion, 030229 sport sciences, medicine.disease, Arthroplasty, Surgery, 03 medical and health sciences, 0302 clinical medicine, Humeral fracture, Operating theater, Clinical investigation, medicine, Internal fixation, business, Reduction (orthopedic surgery)
Abstract

Objective. Proximal humeral fractures are among the most frequent fracture in the adult and their treatment is controversial.The purpose of this paper is to present the most common complications in managing prox- imal humeral fractures, reviewing the literature.The principal complications are mainly caused by biological elements, but are also related to iatrogenic factors.Conclusions. It is very important to provide a correct fracture classification, accurate pa- tient clinical investigation, and to perform all instrumental procedures required to get a correct indication in managing proximal humeral fracture. In case of operative treatment, accurate pre-operatory planning is mandatory. Moreover, the surgeon must consider the feasible intra-operatory complications, such as the possibility to convert an open reduction and internal fixation to a total arthroplasty.In our opinion, the arthroplasty system should be available in every operating theater.

Published
2021
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36. Multidimensional Frailty Predicts Mortality Better than Physical Frailty in Community-Dwelling Older People: A Five-Year Longitudinal Cohort Study

Author

Erica Tavella, C. Prete, Katerin Leslie Quispe Guerrero, Barbara Senesi, Ekaterini Zigoura, Nicola Veronese, Alberto Cella, Clarissa Musacchio, Giacomo Siri, Monica Pomata, Alberto Pilotto, Cella A., Veronese N., Pomata M., Leslie Quispe Guerrero K., Musacchio C., Senesi B., Prete C., Tavella E., Zigoura E., Siri G., and Pilotto A.

Subjects
Gerontology, Male, Health, Toxicology and Mutagenesis, Cardiovascular health, Frail Elderly, Frailty Index, Article, Cohort Studies, Medicine, Humans, Longitudinal Studies, Longitudinal cohort, Geriatric Assessment, Aged, Aged, 80 and over, Frailty, business.industry, Significant difference, Public Health, Environmental and Occupational Health, Mean age, Geriatric assessment, mortality, Frailty, Mortality, Multidimensional prognostic index, Prognosis, Aged, Aged, 80 and over, Cohort Studies, Female, Frail Elderly, Geriatric Assessment, Humans, Independent Living, Longitudinal Studies, Male, Frailty, multidimensional prognostic index, Increased risk, frailty, prognosis, Female, Independent Living, Older people, business
Abstract

Frailty is a common syndrome in older people that carries an increased risk of mortality. Two main models describe frailty, either as a loss of physical functions or as an accumulation of multiple deficits. The aim of our study was to compare the physical frailty index developed in the Cardiovascular Health Study (CHS) with a multidimensional frailty tool, the Multidimensional Prognostic Index (MPI), in predicting death in community-dwelling older subjects. Four hundred and seven community-dwelling older subjects were enrolled. Each subject underwent a comprehensive geriatric assessment (CGA) with calculation of the MPI and CHS index. Mortality was recorded over the following 5 years. In the overall sample (mean age of 77.9 ± 4.5 years; 51.6% female), 53 subjects (13%) died during the 5-year follow-up period. Both the MPI and CHS index were able to predict mortality; however, the MPI was significantly more accurate than the CHS index in predicting mortality (C-index = 0.69 and 0.59, respectively; p < 0.001), with a statistically significant difference of 10%. In conclusion, multidimensional frailty, assessed by the MPI, predicts five-year mortality in community-dwelling older people better than physical frailty, as assessed by the CHS index. These findings suggest the usefulness of assessing frailty by means of CGA-based tools to predict relevant health-negative outcomes in older people.

Published
2021
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37. Characterization of an Amazon Soil Profile by Laser-Induced Breakdown, Raman, and Fluorescence Spectroscopies

Author

José L. Clabel Huamán, Amanda Maria Tadini, Giorgio Saverio Senesi, Stéphane Mounier, Débora M. B. P. Milori, Gustavo Nicolodelli, Sao Carlos Institute of Physics, Universidade de São Paulo = University of São Paulo (USP), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Istituto per la Scienza e la Tecnologia dei Plasmi (ISTP), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Embrapa Instrumentation (CNPDIA), National Nanotechnology Laboratory for Agriculture (LNNA), Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), and Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (grant number: 313685/2020-7)

Subjects
Amazon soils, laser-induced breakdown spectroscopy, Amazon soils laser-induced breakdown spectroscopy Raman spectroscopy fluorescence spectroscopy, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Raman spectroscopy, fluorescence spectroscopy, Geology, Geotechnical Engineering and Engineering Geology
Abstract

International audience; This work aimed to investigate, in detail, the elemental and molecular composition of soil samples collected from the various horizons of an Amazon spodosol profile by combining the atomic technique laser-induced breakdown spectroscopy (LIBS) with two molecular techniques, i.e., Raman and fluorescence spectroscopies. The emission lines of the elements Fe, C, Si, Mg, Al, Ti, Ca, and K with various relative intensities were detected by using LIBS. In particular, C appeared to accumulate in the transition horizon and was proven to be mostly humified by fluorescence analysis. The Raman peaks detected at 465 cm −1 and 800 cm −1 corresponded with the symmetric stretching and bending modes of O-Si-O and Si-OH, respectively. Small shifts toward higher frequencies and slight increases in the width and full width at half maximum (FWHM) of the quartz band at 465 cm −1 appeared in the Tr to K2 horizons, which could be ascribed to a local distortion caused by the high contents of Al of kaolinite mineral phases, as also shown by the LIBS data. Thus, a small amount of kaolinite mineral phase and K measured by LIBS would be present also in the A1 to E2 horizons. The lifetime fluorescence was almost constant in the surface and middle horizons, whereas it increased sharply in the transition horizon and then decreased slightly in the kaolin horizons, which confirmed the presence of more humified recalcitrant organic matter in deeper soil horizons. In conclusion, the combined use of the three spectroscopic techniques appeared to be a very promising approach for studying Amazon soils.

Published
2023
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39. A Peculiar Case of Open Complex Elbow Injury with Critical Bone Loss, Triceps Reinsertion, and Scar Tissue might Provide for Elbow Stability?

Author

Pasquale Gravina, Giulia Facco, Andrea Marchesini, Michele Riccio, Antonio Gigante, Rocco Politano, Letizia Senesi, and Pier Paolo Pangrazi

Subjects
medicine.medical_specialty, Osteosynthesis, business.industry, medicine.medical_treatment, Elbow instability, Elbow, Joint stability, Soft tissue, Case Report, 3D printing, Neurovascular bundle, medicine.disease, Surgery, medicine.anatomical_structure, Olecranon fracture, medicine, Orthopedics and Sports Medicine, Olecranon bone loss, business, Process (anatomy), Reduction (orthopedic surgery), Complex elbow injury
Abstract

Background Complex elbow injuries (CEIs) are severe and rare lesions, difficult to treat correctly due to the different patterns of clinical presentations. Standard methods cannot often be applied. The main goals of the treatment are performing a stable osteosynthesis of all fractures, obtaining a concentric and stable reduction of the elbow by repairing the soft tissue constraint lesions, and allowing early motion. Since the introduction of virtual reality (VR) approaches in clinical practice, three-dimensional (3D) computed tomography (CT) and 3D printing have revolutionised orthopaedic surgeries, thus helping to understand the anatomy and the pathology of complex cases. Case description We discussed a case of CEI, characterised by an extended soft tissue (IIIB Gustilo classification) and neurovascular lesions associated with bone loss in a young female patient. Olecranon fracture was type IIIB according to Mayo classification. We outlined the steps of a pluri-tissue reconstructive approach and stressed the importance of 3D printing in the preoperative planning for such cases. Finally, peculiar final functional patient outcomes were reported. Conclusion In this case, we found out that triceps reinsertion and scar process may provide for the joint stability in a low-demanding patient. 3D printing and VR approaches in clinical practice can be useful in the management of CEIs associated with an important bone and soft tissue loss. How to cite this article Facco G, Politano R, Marchesini A, et al. A Peculiar Case of Open Complex Elbow Injury with Critical Bone Loss, Triceps Reinsertion, and Scar Tissue might Provide for Elbow Stability? Strategies Trauma Limb Reconstr 2021;16(1):53–59.

Published
2021

40. Coordination as a competitive factor: the Peruvian blueberries agribusiness system case

Author

Castro-Santander, Publio, Enriquez-Castillo, Diana, Santiago-Chumacero, Julio, Solano-Gaviño, Juan Carlos, Senesi, Sebastián, and Palau, Hernán

Abstract

Highly healthy fruits, such as blueberries, have seen increasing demand in both traditional and emerging markets in recent years. Peru, a farmer of high-value fresh fruits and vegetables in the southern hemisphere, began exporting blueberries in 2010, becoming the main exporter of this product. The Peruvian blueberry agribusiness system maintains an effective level of coordination between the different economic actors of the production system. For this reason, the objective of this work was to evaluate the level of coordination between the actors of the blueberry agribusiness system that allowed the competitive positioning of Peru in the international market. The theoretical approach used is the Transaction Cost Economics framework, and the methodology consists of an analysis of transactions through the evaluation of governance structures, attributes of transaction and levels of transaction cost. Primary and secondary sources are used for the collection of study data. The results show a high level of coordination between the actors from the existence of the vertical integration structures in the production-packaging-distribution stages of the agribusiness system. This organizational structure was designed by the large blueberry farmers to optimize coordination, make productive operations effective and minimize transaction costs. Investment in specific assets is high, in relation to assets of the temporal, physical and human type. Therefore, the vertical integration -forward- of the farmers safeguards their investments and reduces uncertainty in terms of sales price and product quality, depending on market demand. On the other hand, there is also an efficient coordination relationship between suppliers of inputs and technology, medium and small farmers, packers, wholesale and retail distributors. The predominant organizational structure among these actors is the formal contract, which allows safeguarding investments from the production stage and reducing uncertainty in terms of product quality during marketing. It is concluded that the high level of coordination is a competitive factor of the blueberry agribusiness system in Peru, since the coordination mechanisms developed by the actors allow reducing exchange costs and market uncertainty. The high level of coordination between the actors has boosted exports and consolidated Peru's position as an important player in the commercialization of fresh blueberries worldwide., Proceedings in Food System Dynamics, PROCEEDINGS IN SYSTEM DYNAMICS AND INNOVATION IN FOOD NETWORKS 2022

Published
2022
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41. Turning the clock forward: New pharmacological and non pharmacological targets for the treatment of obesity

Author

Ferrulli, Anna, Terruzzi, Ileana, Senesi, Pamela, Succi, Massimiliano, Cannavaro, Daniele, and Luzi, Livio

Subjects
Nutrition and Dietetics, Diabetes Mellitus, Type 2, Endocrinology, Diabetes and Metabolism, Quality of Life, Medicine (miscellaneous), Humans, Feeding Behavior, Obesity, Cardiology and Cardiovascular Medicine, Transcranial Direct Current Stimulation
Abstract

Aims:Obesity and its main metabolic complication, type 2 diabetes, have attained the status of a global pandemic; there is need for novel strategies aimed at treating obesity and preventing the development of diabetes. A healthy diet and exercise are basic for treatment of obesity but often not enough. Pharmacotherapy can be helpful in maintaining compliance, ameliorating obesity-related health risks, and improving quality of life. In the last two decades, the knowledge of central and peripheral mechanisms underlying homeostatic and hedonic aspects of food intake has significantly increased. Dysregulation of one or more of these components could lead to obesity. Data synthesis:In order to better understand how potential innovative treatment options can affect obesity, homeostatic and reward mechanisms that regulate energy balance has been firstly illustrated. Then, an overview of potential therapeutic targets for obesity, distinguished according to the level of regulation of feeding behavior, has been provided. Moreover, several non-drug therapies have been recently tested in obesity, such as non-invasive neurostimulation: Transcranial Magnetic Stimulation or Transcranial Direct Current Stimulation. All of them are promising for obesity treatment and are almost devoid of side effects, constituting a potential resource for the prevention of metabolic diseases. Conclusions:The plethora of current anti-obesity therapies creates the unique challenge for physicians to customize the intervention, according to the specific obesity characteristics and the intervention side effect profiles; moreover, it allows multimodal approaches addressed to treat obesity and metabolic adaptation with complementary mechanisms.

Published
2022
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45. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Morandi, A, Zambon, A, Di Santo SG, Mazzone, A, Cherubini, A, Mossello, E, Bo, M, Marengoni, A, Bellelli, G, Rispoli, V, Malara, A, Spadea, F, Di Cello, S, Ceravolo, F, Fabiano, F, Chiaradia, G, Amedeo, G, Peluso, L, Taristano, A, Settembrini, V, Capomolla, D, Citrino, A, Scriva, A, Bruno, I, Secchi, R, De Martino, E, Muccinelli, R, Lupi, G, Paonessa, P, Fabbri, A, Passuti, Mt, Castellari, S, Po, A, Gaggioli, G, Varesi, M, Moneti, P, Capurso, S, Latini, V, Ghidotti, S, Riccardelli, F, Macchi, M, Rigo, R, Pascale, C, Bosio, A, Cerrato, F, Bardelli, B, Boffelli, S, Cassinadri, A, Franzoni, S, Spazzini, E, Andretto, D, Tonini, G, Andreani, L, Coralli, M, Balotta, A, Cancelliere, R, Ballardini, G, Simoncelli, M, Mancini, A, Strazzacapa, M, Cavallino, P, Fabio, S, De Filippi, F, Giudice, C, Floris, P, D’Elia, K, Dentizzi, C, Azzini, M, Cazzadori, M, Mastroeni, V, Bertassello, P, Santana, H, Benati, C, Nesta, E, Tobaldini, C, Antonioli, A, Guerini, F, Tambare, E, Mombelloni, P, Fontanini, F, Lassa, G, Pizzorni, C, Oliverio, M, Del Grosso LL, Giavedoni, C, Bidoli, G, Mazzei, B, Corsonello, A, Fusco, S, Vena, S, De Vuono, T, Maiuri, G, Fimognari, Fl, Arone, A, Sgrò, G, Nicolazzo, R, Castegnaro, E, De Rosa, S, Bazzano Sechi, R, Benvenuti, E, Del Lungo, I, Giardini, S, Giulietti, C, Di Bari, M, Barghini, E, Paoli, M, Fiordelli, I, Barucci, R, Sgrilli, F, Bertoletti, E, D'Amico, F, Caronzolo, F, Grippa, A, Lombardo, G, Pipicella, T, Satta, A, Corica, F, Prestipino, Gv, Larosa, D, Cucinotta, D, Basile, G, March, A, Nitti, Mt, Felici, A, Pavan, S, Piazzani, F, Lunelli, A, Dimori, S, Margotta, A, Soglia, T, Postacchini, D, Brunelli, R, Santini, S, Francavilla, M, Macchiati, I, Sorvillo, F, Giuli, C, Mecocci, P, Longo, A, Conestabile della Staffa, M, Perticone, F, Addesi, D, Cella Rosa, P, Bencardino, G, Falbo, T, Grillo, N, Marco, F, Mirella, F, Fantò, F, Isaia, G, Pezzilli, S, Bergamo, D, Furno, E, Rrodhe, S, Lucarini, S, Dijk, B, Dall'Acqua, F, Cappelletto, F, Calvani, D, Becheri, D, Mottino, G, Mitidieri, C, Vito, A, Bartalucci, F, Magherini, L, Malin, N, Boni, F, Gambardella, L, Valente, C, Bracali, I, Foschini, A, Porrino, P, Ceci, G, Bottignole, G, Tibaldi, M, Coppo, E, Ettore, E, Camellini, C, Servello, A, Grassi, A, Rozzini, R, Tironi, S, Grassi, Mg, Troisi, E, Caltagirone, C, Franchini, F, Ratto, F, Pavani, B, Toniolo, S, Gabutto, A, Quazzo, L, Rosatello, A, Suraci, D, Tagliabue, B, Perrone, C, Ferrara, L, Castagna, A, Tremolada, Ml, Castoldi, G, Barbero, S, Oltramonti, D, Piano, S, Serviddio, G, Lo Buglio, A, Gurrera, T, Merlo, V, Rovai, C, Cotroneo, Am, Carlucci, R, Abbaldo, A, Monzani, F, Qasem, Aa, Bini, G, Tafuto, S, Galli, G, Bruni, Ac, Mancuso, G, Calipari, D, De Luca GM, Bernardini, B, Corsini, C, Ciccarelli, M, Dal Farra, S, Cagnin, A, Fragiacomo, F, Pompanin, S, Amodio, P, Cagnin, M, Zurlo, A, Guerra, G, Pala, M, Menozzi, L, Delli Gatti, C, Magon, S, Manfredini, R, De Giorgi, A, Fabbian, F, Tiseo, R, Misurati, E, Boari, B, Molino, C, Gallerani, M, Di Francesco, V, Faccioli, S, Pellizzari, L, Fontana, G, Barbagallo, G, Limone, G, Lunardelli, Ml, Martini, E, Ferrari, E, Macchiarulo, M, Corneli, M, Bacci, M, Battaglia, G, Anastasio, L, Lo Storto MS, Seresin, C, Simonato, M, Loreggian, M, Cestonaro, F, Durando, M, Latella, R, Mazzoleni, M, Russo, G, Ponte, M, Valchera, A, Salustri, G, Petritola, D, Costa, A, Sinforiani, E, Cotta, Mr, Pizio, Rn, Cester, A, Formilan, M, Bonometto, P, Carbone, P, Cazzaniga, I, Appollonio, I, Cereda, D, Stabile, A, Xhani, R, Acampora, R, Tremolizzo, L, Pieruzzi, F, Ciaccio, A, Pontecorvi, V, Butti, C, Mokini, Z, Vitale, G, Amigoni, M, Sparacino, M, Bottacchi, E, Bucciantini, E, Di Giovanni, M, Franchi, F, Lucchetti, L, Mariani, C, Grande, G, Rapazzini, P, Mauri, M, Romanelli, G, Nicosia, F, Margola, A, Bonardelli, A, Latronico, N, Porcella, L, Portolani, N, Concoreggi, C, Grassini, C, Salvi, A, Banchetti, L, Spagnoli, F, Apuzzo, R, Fontanella, M, Ceraso, A, Castelli, F, Fugazza, L, Guerrini, C, De Paduanis, G, Iallonardo, L, Palumbo, P, Zuliani, G, Ortolani, B, Capatti, E, Soavi, C, Bianchi, L, Francesconi, D, Miselli, A, Brombo, G, Romagnoli, T, Pazzaglini, C, Dall’Agata, M, Suardi, T, Zaccarini, C, Riva, M, Mirra, G, Muti, E, Bottura, R, Gianpaolo, M, Secreto, P, Bisio, E, Cecchettani, M, Naldi, T, Pallavicino, A, Pugliese, M, Iozzo, Rc, Grassi, G, Bombelli, M, Dell’Oro, R, Quarti Trevano, F, Giussani, Cg, Paternò, G, Contro, E, Mannironi, A, Giorli, E, Oberti, S, Fierro, B, Piccoli, T, Giacalone, F, Mandas, A, Serchisu, L, Costaggiu, D, Pinna, E, Orrù, F, Mannai, M, Cordioli, Z, Pelizzari, L, Turcato, E, Arduini, P, Cacace, C, Rimondi, B, Chiloiro, R, Cimino, R, Ruberto, C, Ruotolo, G, Gareri, P, Greco, L, Dal Santo, P, Andriolli, A, Burattin, G, Rossi, L, Cervati, G, Andreolli, A, Catalano, G, Tezza, F, Pizzardini, M, Laura, S, Crippa, P, Aloisio, P, Di Monda, T, Malighetti, A, Galbassini, G, Ivaldi, C, Russo, Am, Bennati, E, Pino, E, Zavarise, G, Pesci, A, Suigo, G, Faverio, P, Gori, A, Perego, S, Zanasi, M, Moniello, G, Rostagno, C, Cartei, A, Polidori, G, Ungar, A, Melis, Mr, Martellini, E, Torrini, M, Giordano, A, Leone, G, Migliorini, M, Caramelli, F, Battiston, B, Berardino, M, Cavallo, S, Massè, A, Santoro, A, Lombardi, B, D'Ippolito, P, Furini, A, Villani, D, Raimondi, C, Guarneri, M, Paolucci, S, Bassi, A, Coiro, P, De Angelis, D, Morone, G, Venturiero, V, Palleschi, L, Raganato, P, Di Niro, G, Rosa, Ca, Bove, L, Imoscopi, A, Tibaldi, V, Calvi, E, Clementi, C, Zanocchi, M, Agosta, L, Crasia, A, Spertino, A, Nortarelli, A, Provenzano, G, Principato, P, Criasia, A, Spertino, E, Mari, D, Romano, Fy, Rosini, F, Mansi, M, Rossi, S, Riccardelli, A, Inzaghi, L, Bonini, G, Rossi, P, Potena, A, Lichii, M, Candiani, T, Grimaldi, W, Bertani, E, Porta, A, Calogero, P, Pinto, D, Bernardi, R, Nicolino, F, Galetti, C, Gianstefani, A, Corvalli, G, Mulazzani, L, Odetti, P, Monacelli, F, Prefumo, M, Canepa, M, Minaglia, C, Paolisso, G, Rizzo, Mr, Prestano, R, Dalise, Am, Barra, D, Dal Bosco, L, Asprinio, V, Dallape, L, Perina, E, Incalzi, Ra, Rossi Bartoli, I, Pluderi, A, Maina, A, Pecoraro, E, Sciarra, M, Prudente, A, Maina, P, Mete, F, Ventura, M, Cesari, L, Pernigotti, Lm, Santangelo, T, Benini, L, Levato, F, Mhiuta, V, Alius, F, Davidoaia, D, Giardini, V, Garancini, M, Bellamoli, C, Terranova, L, Bozzini, C, Tosoni, P, Provoli, E, Cascone, L, Dioli, A, Ferrarin, G, Bucci, A, Bua, G, Fenu, S, Bianchi, G, Casella, S, Romano, V, Poli, M, Mascherona, I, Belotti, G, Cavaliere, S, Cuni, E, Merciuc, N, Oberti, R, Veneziani, S, Capoferri, E, De Bernardi, E, Colombo, K, Bellini, G, Bravi, M, Negrinotti, N, D'Arcangelo, P, Montenegro, N, Montanari, R, Lamanna, P, Gasperini, B, Montesi, I, Diotallevi, S, Altobelli, G, Calcinaro, F, Palamà, C, Di Emidio, C, Scarpini, E, Arighi, A, Fumagalli, G, Basilico, P, De Amicis Migone, M, Mancarella, M, Maira, D, Granata, A, Ranalli, C, Cammilli, A, Cavallini, Mc, Tricca, M, Natella, D, Gabbani, L, Tesi, F, Martella, L, Imbrici, R, Guerrini, G, Scotuzzi, Am, Sozzi, F, Valenti, L, Chiarello, A, Monella, M, Pilotto, A, Prete, C, Senesi, B, Meta, Ac, Pendenza, E, Pasqualetti, G, Polini, A, Tognini, S, Ballino, E, Dell'Aquila, G, Gasparrini, Pm, Marotti, E, Migale, M, Scrimieri, A, Falsetti, L, Toigo, G, Ceschia, G, Rosso, A, Tongiorgi, C, Scarpa, C, Pacchioni, M, De Dominicis, L, Pucci, E, Renzi, S, Cartechini, E, Tomassini, Pf, Del Gobbo, M, Ugenti, F, Romeo, P, Nardelli, A, Lauretani, F, Visioli, S, Montanari, I, Ermini, F, Pigato, G, Simeone, E, Colameco, F, Cecamore, A, Scurti, R, Lupinetti, Mc, Barbujani, M, Giampieri, M, Amoruso, R, Piccinini, M, Ferrari, C, Gambetti, C, Sfrappini, M, Semeraro, L, Striuli, R, Pelliccioni, G, Marinelli, D, Fabi, K, Rossi, T, Pesallaccia, M, Sabbatini, D, Gobbi, B, Cerqua, R, Tagliani, G, Schlauser, E, Caser, L, Caramello, E, Sandigliano, F, Rosso, G, Ferrari, A, Bendini, C, Davoli, Ml, Casella, M, Prampolini, R, Scevola, M, Vitale, E, Brugiolo, V, Fagherazzi, C, Scarpa, A, Zara, D, Bertozzo, G, Granziera, S, Berazzuol, M, Maugeri, D, Sorace, R, Anzaldi, M, De Gesu, R, Morrone, G, Davolio, F, Fabbo, A, Palmieri, M, Zoli, M, Forti, P, Pirazzoli, L, Fabbri, E, Terenzi, L, Bergolari, F, Wenter, C, Ruffini, I, Insam, M, Abraham, E, Kirchlechner, C, Antonino, L, Grazia, Am, Parise, P, Boccali, A, Amici, S, Gambacorta, M, Lasagni, A, Lovati, R, Giovinazzo, F, Kimak, E, Zappa, P, Medici, F, Lo Castro, M, Mauro, F, De Luca, A, Sancesario, G, Martorana, A, Scaricamazza, B, Di Lorenzo, F, Liguori, C, Lasco, A, Vita, N, Giomi, M, Forte, F, Padovani, A, Rozzini, L, Caratozzolo, S, Cottino, M, Vitali, S, Marelli, E, Tripi, G, Miceli, S, Urso, G, Grioni, G, Vezzadini, G, Misaggi, G, Forlani, C, Avanzi, S, Saulle, S, Casarini, C, Viggiano, M, Alberto, L, Ghianda, D, Iemolo, F, Sanzaro, E, D'Asta, G, Proietto, M, Carnemolla, A, Razza, G, Spadaro, D, Bertolotti, M, Mussi, C, Neviani, F, Chiesa, R, Guerzoni, V, Morselli, L, Venturelli, F, Tarozzi, A, Balestri, F, Mannarino, G, Bigolari, M, Natale, A, Grassi, S, Bottaro, C, Stefanelli, S, Bovone, U, Tortorolo, U, Quadri, R, Ponzetto, M, Frasson, P, Annoni, G, Bruni, A, Confalonieri, R, Corsi, M, Moretti, D, Teruzzi, F, Umidi, S, Mazzola, P, Persico, I, Olivieri, G, Bonfanti, A, Hajnalka, S, Galeazzi, M, Massariello, F, Anzuini, A, Caffarra, P, Barocco, F, Spallazzi, M, Ceda, Gp, Morganti, S, Artoni, A, Chioatto, P, Bortolamei, S, Soattin, L, Borelli, B, Barilaro, G, Carmen, R, Bertazzoli, M, Rota, E, Adobati, A, Zuccher, P, Fabbro, Ad, Lo Nigro, A, Franchetti, L, Toniolo, M, Marcuzzo, C, Rollone, M, Guerriero, F, Sgarlata, C, Zatti, G, Piatti, M, Graci, J, Benati, G, Boschi, F, Biondi, M, Fiumi, N, Tamburini, E, Locatelli, Sm, Mauri, S, Beretta, M, Margheritis, L, Desideri, G, Liberatore, E, Carucci, Ac, Bonino, P, Caput, M, Antonietti, Mp, Polistena, G, De la Pierre, F, Mari, M, Massignani, P, Tombesi, F, Selvaggio, F, Verbo, B, Bodoni, P, Marchionni, N, Sabatini, T, Mussio, E, Magni, E, Bianchetti, A, Crucitti, A, Titoldini, G, Cossu, B, Fascendini, S, Licini, C, Tomasoni, A, Calderazzo, M, Tropiano, D, Luganà, V, Melotti, Rm, Lilli, A, Buda, S, Adversi, M, Noro, G, Turco, R, Ubezio, Mc, Mantovani, Ar, Viola, Mc, Serrati, C, Pretta, S, Infante, M, Gentile, S, D'Ambrosio, V, Mazzanti, P, Brambilla, C, Sportelli, S, Platto, C, Faraci, B, Quattrocchi, D, Pisu, C, Sicuro, F, Zagnoni, P, Ghiglia, S, Mosca, M, Corazzin, I, Deola, M, Biagini, Ca, Bencini, F, Cantini, C, Tonon, E, Pierinelli, S, Onofrj, M, Thomas, A, Filomena, B, Bonanni, L, Cacchiò, G, Comi, G, Magnani, G, Santangelo, R, Mazzeo, S, Caso, F, Cecchetti, G, Sant’Angelo, R, Barbieri, C, Giroldi, L, Bandini, F, Masina, M, Malservisi, S, Cicognani, A, Ricca, L, Piccininni, M, Tassinari, T, Brogi, D, Sugo, A, Filippi, A, Manfredi, S, Vanni, V, Usai, Ca, Colombo, E, Renna, Fv, Sanchella, A, Prete, M, Bisagni, P, Masini, R, Carrabetta, S, Barone, A, Razzano, M, Imperoli, G, Bini, A, Serra, F, D’Agostino, V, Gianolla, F, Pietrangeli, L, Velardi, A, Di Cello, E, Rosati, C, Casali, N, Sessa, M, Abruzzi, L, Costanzi, C, Bini, P, Pignata, M, Bonagurio, E, Vollery, M, Carrieri, G, Cioni, G, Toschi, A, Metra, M, Ranieri, P, Zucchelli, A, Ceccon, A, Magrin, L, Marin, S, Barbara, S, Ghedini, L, Moroni, M, Pitagora, M, Pallotti, Mc, Gottardi, F, Tomasoni, C, Cappuccio, M, Guerini, S, Guerini, V, Merla, L, Tovaglieri, M, Bongiorni, N, Grillo, A, Arenare, F, Tonino, M, Kanah, D, Vianello, Pg, Balducci, U, Sidoti, V, Montanari, S, Murelli, T, Busonera, F, Albanese, P, Maselli, M, Bolzetta, F, Fabris, R, Durante Mangoni, E, Testoni, M, Di Stefano, F, Seccia, L, Morabito, D, Sonzina, V, Fabiano, M, Di Giorgio Annabella, De Cosmo Salvatore, Greco, A, D’Onofrio, G, Sancarlo, D, Resta, G, Girardello, R, Minervini, S, Boni, M, Vitali, Mg, Pizzoni, M, De Colle, P, Frattola, A, Orlandini, F, La Regina, M, Filice, M, Padulo, F, Margheriti, C, Rolano, D, Sacchelli, C, Moscatelli, G, Radaelli, G, Montini, E, Novello, M, Bramuzzo, I, Bertin, N, Rinaldo, E, Paolillo, C, Riccardi, A, Benedetti, C, Ricci, B, Montagna, F, Cutaia, C, Baca, O, Colombo, M, Procino, G, Tararà, R, Dell’Acqua, D, Cislaghi, S, Cairati, M, Porta, M, Scaglione, L, De Feo, M, Vertolli, P, Salvati, L, Cinotti, S, De Santis, V, Biferi, E, Cheli, P, Rebizzo, R, Minisola, S, Colangelo, L, Abete, P, Liguori, I, Curcio, F, Spassini, G, Engheben, M, Rotunno, S, Arosio, P, Angelini, C, Reggiani, F, Cappelli, A, Marcheselli, S, Fratticci, L, Ranzani, P, Cesarini, S, Cerini, A, Generoso, U, Gallucci, F, Serra, E, Sola, M, Delitala, A, Pes, C, Lobianco, G, Giani, A, Famularo, S, Sandini, M, Pinotti, E, Gianotti, L, Alessandro, D, Chiara, P, Giulia, L, Alessandro, G, Giannotti, L, Battuello, A, Pintore, G, Rossi, A, Rubele, S, Sant, S, Vignati, M, Clerici, D, Rosa, F, Bandirali, Mp, Cattaneo, N, Boffi, L, Avalli, L, Scanziani, M, De Notaris, S, Del Santo, P, Catalano, F, Fogli, D, Di Bella, G, Landi, F, 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A., Morandi A., Zambon A., Di Santo S.G., Mazzone A., Cherubini A., Mossello E., Bo M., Marengoni A., Piccoli T., Bellelli G., Rispoli V., Malara A., Spadea F., Di Cello S., Ceravolo F., Fabiano F., Chiaradia G., Gabriele A., Lenino P., Andrea T., Settembrini V., Capomolla D., Citrino A., Scriva A., Bruno I., Secchi R., De Martino E., Muccinelli R., Lupi G., Paonessa P., Fabbri A., Passuti M.T., Castellari S., Po A., Gaggioli G., Varesi M., Moneti P., Capurso S., Latini V., Ghidotti S., Riccardelli F., Macchi M., Rigo R., Claudio P., Angelo B., Flavio C., Benedetta B., Boffelli S., Cassinadri A., Franzoni S., Spazzini E., Andretto D., Tonini G., Andreani L., Coralli M., Balotta A., Cancelliere R., Ballardini G., Simoncelli M., Mancini A., Strazzacapa M., Fabio S., De Filippi F., Giudice C., Dentizzi C., Azzini M., Cazzadori M., Mastroeni V., Bertassello P., Claudia Benati H.S., Nesta E., Tobaldini C., Guerini F., Elena T., Mombelloni P., Fontanini F., Gabriella L., Pizzorni C., Oliverio M., Del Grosso L.L., Giavedoni C., Bidoli G., Mazzei B., Corsonello A., Fusco S., Vena S., De Vuono T., Maiuri G., Luca F.F., Andrea A., Giovanni S., Rossella N., Castegnaro E., De Rosa S., Sechi R.B., Benvenuti E., Del Lungo I., Giardini S., Giulietti C., Mauro D.B., Eleonora B., Martina P., Irene F., Riccardo B., Federica S., Ilaria D.L., Bertoletti E., D'Amico F., Caronzolo F., Grippa A., Lombardo G., Pipicella T., Antonino S., Francesco C., Valeria P.G., Daniela L., Domenico C., Giorgio B., March A., Nitti M.T., Felici A., Pavan S., Piazzani F., Lunelli A., Dimori S., Margotta A., Soglia T., Postacchini D., Brunelli R., Santini S., Francavilla M., Macchiati I., Sorvillo F., Giuli C., Mecocci P., Longo A., Perticone F., Addesi D., Rosa P.C., Bencardino G., Falbo T., Grillo N., Marco F., Mirella F., Fanto F., Isaia G., Pezzilli S., Bergamo D., Furno E., Rrodhe S., Lucarini S., Dijk B., Dall'Acqua F., Cappelletto F., Calvani D., Becheri D., Giuseppe M., Costanza M., Vito A., Francesca B., Magherini L., Novella M., Franca B., Lucia Gambardella P.M., Valente C., Ilaria B., Alice F., Porrino P., Ceci G., Giuliana B., Michela T., Eleonora C., Ettore E., Camellini C., Servello A., Grassi A., Rozzini R., Tironi S., Grassi M.G., Troisi E., Carlo C., Simona Gabriella D.S., Flaminia F., Federica R., Beatrice P., Sofia T., Gabutto A., Quazzo L., Rosatello A., Suraci D., Tagliabue B., Perrone C., Ferrara L., Castagna A., Tremolada M.L., Giuseppe C., Stefano B., Davide O., Piano S., Serviddio G., Lo Buglio A., Gurrera T., Merlo V., Rovai C., Cotroneo A.M., Carlucci R., Abbaldo A., Monzani F., Qasem A.A., Bini G., Tafuto S., Galli G., Bruni A.C., Mancuso G., Calipari D., Giuseppe Massimiliano D.L., Bernardini B., Corsini C., Michele C., Sara D.F., Cagnin A., Fragiacomo F., Pompanin S., Piero A., Marco C., Zurlo A., Guerra G., Pala M., Menozzi L., Gatti C.D., Magon S., Roberto M., Alfredo D.G., Fabio F., Ruana T., Elisa M., Christian M., Marco P., Massimo G., Di Francesco V., Faccioli S., Pellizzari L., Giorgia F., Barbagallo G., Lunardelli M.L., Martini E., Ferrari E., Macchiarulo M., Corneli M., Bacci M., Battaglia G., Anastasio L., Lo Storto M.S., Seresin C., Simonato M., Loreggian M., Cestonaro F., Durando M., Latella R., Mazzoleni M., Russo G., Ponte M., Valchera A., Salustri G., Petritola D., Costa A., Sinforiani E., Cotta M.R., Pizio R.N., Cester A., Formilan M., Pietro B., Carbone P., Cazzaniga I., Appollonio I., Cereda D., Stabile A., Xhani R., Acampora R., Tremolizzo L., Federico P., Antonio C., Valerio P., Cesare B., Zhirajr M., Giovanni V., Maria A., Mariaelena S., Bottacchi E., Bucciantini E., Di Giovanni M., Franchi F., Lucchetti L., Mariani C., Grande G., Rapazzini P., Marco M., Romanelli G., Franco N., Alessio M., Nicola L., Laura P., Nazario P., Chiara G., Soccorso P., Andrea S., Luca B., Francesca S., Roberto A., Anna C., Fugazza L., Guerrini C., De Paduanis G., Iallonardo L., Palumbo P., Zuliani G., Ortolani B., Capatti E., Soavi C., Bianchi L., Francesconi D., Miselli A., Gloria B., Tommaso R., Chiara P., Agata M.M., Marco D.A., Luca M., Gianluca G., Suardi T., Zaccarini C., Manuela R., Mirra G., Muti E., Bottura R., Gianpaolo M., Secreto P., Bisio E., Cecchettani M., Naldi T., Pallavicino A., Pugliese M., Iozzo R.C., Grassi G., Michele B., Raffaella D.O., Fosca Q.T., Giorgio G.C., Giovanni P., Ernesto C., Mannironi A., Giorli E., Oberti S., Fierro B., Giacalone F., Mandas A., Serchisu L., Costaggiu D., Pinna E., Orru F., Mannai M., Cordioli Z., Pelizzari L., Turcato E., Arduini P., Cacace C., Chiloiro R., Cimino R., Ruberto C., Giovanni R., Pietro G., Laura G., Alberto C., Carmen R., Santo P.D., Andriolli A., Burattin G., Rossi L., Andreolli Antonino C.G., Tezza F., Maddalena P., Laura S., Crippa P., Aloisio P., Di Monda T., Malighetti A., Galbassini G., Salutis D., Ivaldi C., Russo A.M., Bennati E., Pino E., Zavarise G., Pesci A., Suigo G., Faverio P., Andrea G., Sabrina P., Zanasi M., Moniello G., Rostagno C., Cartei A., Polidori G., Ungar A., Melis M.R., Martellini E., Enrico M., Monica T., Antonella G., Giovanna L., Migliorini M., Caramelli F., Battiston B., Berardino M., Cavallo S., Alessandro M., Anna S., Lombardi B., D'Ippolito P., Furini A., Villani D., Clara R., Guarneri M., Paolucci S., Bassi A., Coiro P., De Angelis D., Morone G., Venturiero V., Palleschi L., Raganato P., Di Niro G., Rosa C.A., Loredana B., Imoscopi A., Tibaldi V., Bottignole G G., Calvi E., Clementi C., Zanocchi M., Agosta L., Nortarelli A., Provenzano G., Mari D., Romano F.Y., Rosini F., Mansi M., Rossi S., Geriatria A.R., Inzaghi L., Bonini G., Rossi P., Potena A., Lichii M., Candiani T., Grimaldi W., Bertani E., Alessandra P., Calogero P., Pinto D., Bernardi R., Nicolino F., Galetti C., Gianstefani A., Giulia C., Lorenzo M., Odetti P., Monacelli F., Prefumo M., Fiammetta M., Canepa M., Minaglia C., Paolisso G., Rizzo M.R., Prestano R., Dalise A.M., Barra D., Bosco L.D., Asprinio V., Dallape L., Perina E., Incalzi R.A., Bartoli I.R., Pluderi A., Maina A., Pecoraro E., Sciarra M., Prudente A., Paola M., Francesca M., Manuel V., Luisella C., Maria P.L., Tina S., Benini L., Levato F., Mhiuta V., Alius F., Davidoaia D., Giardini V., Garancini M., Bellamoli C., Terranova L., Bozzini C., Tosoni P., Provoli E., Cascone L., Dioli A., Ferrarin G., Bucci A., Bua G., Fenu S., Bianchi G., Casella S., Romano V., Maurizio P., Mascherona I., Belotti G., Cavaliere S., Cuni E., Merciuc N., Oberti R., Veneziani S., Capoferri E., De Bernardi E., Colombo K., Bravi M., Nicoletta N., D'Arcangelo P., Montenegro N., Montanari R., Lamanna P., Gasperini B., Isabella M., Stefania D., Gaia A., Filippo C., Palama C., Di Emidio C., Scarpini E., Arighi A., Fumagalli G., Basilico P., De Amicis Margherita M., Marta M., Diletta M., Granata A., Ranalli C., Cammilli A., Cavallini M.C., Tricca M., Natella D., Gabbani L., Tesi F., Martella L., Imbrici R., Guerrini G., Scotuzzi A.M., Sozzi F., Valenti L., Chiarello A., Monia M., Pilotto A., Prete C., Senesi B., Meta A.C., Pendenza E., Pasqualetti G., Polini A., Tognini S., Ballino E., Dell'Aquila G., Gasparrini P.M., Marotti E., Migale M., Scrimieri A., Falsetti L., Salvi A., Toigo G., Ceschia G., Rosso A., Tongiorgi C., Scarpa C., De Dominicis L., Pucci E., Renzi S., Cartechini E., Tomassini P.F., Del Gobbo M., Ugenti F., Romeo P., Nardelli A., Lauretani F., Visioli S., Montanari I., Ermini F., Giordano A., Pigato G., Simeone E., Barbujani M., Giampieri M., Amoruso R., Piccinini M., Ferrari C., Gambetti C., Sfrappini M., Semeraro L., Striuli R., Pelliccioni G., Marinelli D., Fabi K., Rossi T., Pesallaccia M., Sabbatini D., Gobbi B., Cerqua R., Tagliani G., Schlauser E., Caser L., Caramello E., Sandigliano F., Rosso G., Ferrari A., Bendini C., Luisa D.M., Casella M., Prampolini R., Scevola M., Vitale E., Roberto B., Carlo F., Sergio F., Alberto S., Daniela Z., Giulia B., Serena G., Maugeri D., Sorace R., Anzaldi M., De Gesu R., Morrone G., Davolio F., Fabbo A., Palmieri M., Zoli M., Forti P., Pirazzoli L., Fabbri E., Terenzi L., Bergolari F., Wenter C., Ruffini I., Insam M., Abraham E., Kirchlechner C., Cucinotta D., Antonino L., Basile G., Grazia A.M., Parise P., Boccali A., Amici S., Gambacorta M., Lasagni A., Lovati R., Giovinazzo F., Kimak E., Zappa P., Medici F., Lo Castro M., Mauro F., De Luca A., Sancesario G., Martorana A., Scaricamazza B., Toniolo S., Di Lorenzo F., Liguori C., Lasco A., Vita N., Giomi M., Forte F., Padovani A., Rozzini L., Ceraso A., Salvatore C., Cottino M., Vitali S., Marelli E., Tripi G., Miceli S., Urso G., Grioni G., Vezzadini G., Misaggi G., Forlani C., Avanzi S., Serena S., Claudia C., Marilena V., Alberto L., Diego G., Alessandro G., Iemolo F., Sanzaro E., D'Asta G., Proietto M., Carnemolla A., Razza G., Spadaro D., Bertolotti M., Mussi C., Neviani F., Roberto C., Valentina G., Linda M., Francesca V., Tarozzi A., Balestri F., Mannarino G., Bigolari M., Natale A., Grassi S., Bottaro C., Stefanelli S., Bovone U., Tortorolo U., Quadri R., Leone G., Ponzetto M., Frasson P., Annoni G., Bruni A., Confalonieri R., Corsi M., Moretti D., Teruzzi F., Umidi S., Mazzola P., Perego S., Persico I., Olivieri G., Bonfanti A., Hajnalka S., Galeazzi M., Massariello F., Anzuini A., Caffarra P., Barocco F., Spallazzi M., Paolo C.G., Simonetta M., Chioatto P., Bortolamei S., Soattin L., Ruotolo G., Beneamino B., Giuseppe B., Bertazzoli M., Rota E., Adobati A., Scarpa A., Granziera S., Zuccher P., Fabbro A.D., Zara D., Lo Nigro A., Franchetti L., Toniolo M., Marcuzzo C., Rollone M., Guerriero F., Sgarlata C., Masse A., Zatti G., Piatti M., Graci J., Benati G., Boschi F., Biondi M., Fiumi N., Erika T., Locatelli S.M., Mauri S., Beretta M., Margheritis L., Desideri G., Liberatore E., Carucci A.C., Bonino P., Caput M., Antonietti M.P., Polistena G., De la Pierre F., Mari M., Massignani P., Tombesi F., Selvaggio F., Verbo B., Bodoni P., Marchionni N., Sabatini T., Mussio E., Magni E., Bianchetti A., Crucitti A., Titoldini G., Cossu B., Fascendini S., Licini C., Tomasoni A., Calderazzo M., Daniela T., Valentina L., Melotti R.M., Lilli A., Buda S., Adversi M., Noro G., Turco R., Ubezio M.C., Mantovani A.R., Viola M.C., Serrati C., Pretta S., Infante M., Gentile S., D'Ambrosio V., Mazzanti P., Brambilla C., Sportelli S., Platto C., Faraci B., Quattrocchi D., Pernigotti L.M., Pisu C., Sicuro F., Zagnoni P., Ghiglia S., Mosca M., Corazzin I., Deola M., Biagini C.A., Bencini F., Cantini C., Tonon E., Pierinelli S., Onofrj M., Thomas A., Filomena B., Bonanni L., Gabriella C., Comi G., Magnani G., Santangelo R., Mazzeo S., Francesca C., Giordano C., Roberto S.A., Barbieri C., Giroldi L., Bandini F., Masina M., Malservisi S., Cicognani A., Ricca L., Piccininni M., Tassinari T., Brogi D., Sugo A., Alessandra F., Sonia M., Valerio V., Andrea U.C., Enrico C., Vera R.F., Assunta S., Gianmaria Z., Mauro P., Barone A., Razzano M., Giuseppe I., Angela B., Francesco S., Valeria D.A., Federico G., Lucia P., Antonella V., Elisabetta D.C., Cristina R., Nadia C., Maria S., Luciano A., Chiara C., Bini P., Pignata M., Enrico B., Maria V., Giovanni C., Giorgio C., Piera R., Alberto Z., Ceccon A., Magrin L., Marin S., Barbara S., Matteo M., Caterina P.M., Carla R., Federica G., Clara T., Melania C., Giampaolo B., Stefano G., Valeria G., Lucia M., Giovambattista D., Ester L., Cecilia C.A., Maurizio T., Nadia B., Grillo A., Arenare F., Tonino M., David K., Giorgio V.P., Ubaldo B., Vincenzo S., Stefano M., Marino F., Busonera Flavio M.T., Paolo A., Monica M., Francesco B., Roberto F., Paolo B., DuranteMangoni E., Testoni M., Fabio D.S., Loredana S., Valeria S., Fabiano M., Annabella D.G., Salvatore D.C., Greco A., Grazia D.O., Daniele S., Gianluca R., Renzo G., Sergio M., Morena B., Vitali M., Marina P., Paolo D.C., Cristina S., Orlandini F., La Regina M., Desiree A., Mario B., Paola P., Padulo F., Cristina M., Dario R., Giancarla M., Guido R., Elena M., Marileda N., Igor B., Nicole B., Elena R., Paolillo C., Riccardi A., Claudia B., Barbara R., Silvia V., Oliver B., Mauro C., Eleonora M., Giuseppe P., Rosaria T., Maria C., Davide D.A., Stefania C., Massimo P., Luca S., Martina D.F., Paola V., Lia S., Sandro C., Valentina D.S., Erminia B., Paola C., Romina R., Minisola S., Luciano C., Pasquale A., Ilaria L., Guglielmo S., Marco E., Sara R., Paola A., Claudio A., Francesco R., Alessandro C., Simona M., Lara F., Paola R., Simonetta C., Antonella C., Generoso U., Fernando G., Giuliano C., Emanuela S., Mariolina S., Alessandro D., Giulia L., Famularo S., Sandini M., Pinotti E., Gianotti L., Antonella B., Giulia P., Sante G., Rossi A., Rubele S., Sant S., Marco V., Danila C., Fabio R., Bandirali M.P., Nicoletta C., Laura B., Paolo T., Luciano T., Leonello A., Margherita S., Stefania D.N., Pierluigi D.S., Laura R., Fabiana T., Giovanna C., Antonino A., Felice C., Danilo F., Giovanna D.B., Francesco L., Salini S., Angela B.M., Giorgetta C., Giovanni G., Gerardo B., Silvio R., Letizia S., Davide B., Rosaria R.M., Maria D.A., Raffaele P., Palmieri V.O., Palasciano G., Belfiore A., Portincasa P., Carlo S., Alessia D., Valiani V., Carolina B., Tiziana C., Paola T., Ugo P., Giacomo P., Castellano M., Anna G., Elisa C., Federica C., Antonietta C.M., Luigi M., Fabio L., Salvatore B., Gelosa G., Viviana A.T., Piras V., Andrea C., Alessandra B., Coen D., Magliola R., Milanesio D., Muzzulini C.L., Paolo F., Marinella T., Sofia C.M., Marta B., Siano P., Capo G., Napoletano R., Cecilia P., Mancini C., Del Buono C., De Bartolomeo G., Addolorata M., Carmen C., Giovanni V.A., Moschettini G., Franco M., Daniela R., D'Amico G., Mirella P., Endrizzi C., Trotta L., Ciarambino T., Orazio Z., Emanuela T., Marta S., Thomas F., Giacomo T., Ignazio D.F., Andrea B., Giuseppe O., Emanuela F., Serena A., Elena D.I., Serena B., Erika N., Roberto S., Elena S., Manuela P., Francesca A., Angelo T., Morandi, A, Zambon, A, Di Santo, S, Mazzone, A, Cherubini, A, Mossello, E, Bo, M, Marengoni, A, Bellelli, G, Rispoli, V, Malara, A, Spadea, F, Di Cello, S, Ceravolo, F, Fabiano, F, Chiaradia, G, Gabriele, A, Lenino, P, Andrea, T, Settembrini, V, Capomolla, D, Citrino, A, Scriva, A, Bruno, I, Secchi, R, De Martino, E, Muccinelli, R, Lupi, G, Paonessa, P, Fabbri, A, Passuti, M, Castellari, S, Po, A, Gaggioli, G, Varesi, M, Moneti, P, Capurso, S, Latini, V, Ghidotti, S, Riccardelli, F, Macchi, M, Rigo, R, Claudio, P, Angelo, B, Flavio, C, Benedetta, B, Boffelli, S, Cassinadri, A, Franzoni, S, Spazzini, E, Andretto, D, Tonini, G, Andreani, L, Coralli, M, Balotta, A, Cancelliere, R, Ballardini, G, Simoncelli, M, Mancini, A, Strazzacapa, M, Fabio, S, De Filippi, F, Giudice, C, Dentizzi, C, Azzini, M, Cazzadori, M, Mastroeni, V, Bertassello, P, Claudia Benati, H, Nesta, E, Tobaldini, C, Guerini, F, Elena, T, Mombelloni, P, Fontanini, F, Gabriella, L, Pizzorni, C, Oliverio, M, Del Grosso, L, Giavedoni, C, Bidoli, G, Mazzei, B, Corsonello, A, Fusco, S, Vena, S, De Vuono, T, Maiuri, G, Luca, F, Andrea, A, Giovanni, S, Rossella, N, Castegnaro, E, De Rosa, S, Sechi, R, Benvenuti, E, Del Lungo, I, Giardini, S, Giulietti, C, Mauro, D, Eleonora, B, Martina, P, Irene, F, Riccardo, B, Federica, S, Ilaria, D, Bertoletti, E, D'Amico, F, Caronzolo, F, Grippa, A, Lombardo, G, Pipicella, T, Antonino, S, Francesco, C, Valeria, P, Daniela, L, Domenico, C, Giorgio, B, March, A, Nitti, M, Felici, A, Pavan, S, Piazzani, F, Lunelli, A, Dimori, S, Margotta, A, Soglia, T, Postacchini, D, Brunelli, R, Santini, S, Francavilla, M, Macchiati, I, Sorvillo, F, Giuli, C, Mecocci, P, Longo, A, Perticone, F, Addesi, D, Rosa, P, Bencardino, G, Falbo, T, Grillo, N, Marco, F, Mirella, F, Fanto, F, Isaia, G, Pezzilli, S, Bergamo, D, Furno, E, Rrodhe, S, Lucarini, S, Dijk, B, Dall'Acqua, F, Cappelletto, F, Calvani, D, Becheri, D, Giuseppe, M, Costanza, M, Vito, A, Francesca, B, Magherini, L, Novella, M, Franca, B, Lucia Gambardella, P, Valente, C, Ilaria, B, Alice, F, Porrino, P, Ceci, G, Giuliana, B, Michela, T, Eleonora, C, Ettore, E, Camellini, C, Servello, A, Grassi, A, Rozzini, R, Tironi, S, Grassi, M, Troisi, E, Carlo, C, Simona Gabriella, D, Flaminia, F, Federica, R, Beatrice, P, Sofia, T, Gabutto, A, Quazzo, L, Rosatello, A, Suraci, D, Tagliabue, B, Perrone, C, Ferrara, L, Castagna, A, Tremolada, M, Giuseppe, C, Stefano, B, Davide, O, Piano, S, Serviddio, G, Lo Buglio, A, Gurrera, T, Merlo, V, Rovai, C, Cotroneo, A, Carlucci, R, Abbaldo, A, Monzani, F, Qasem, A, Bini, G, Tafuto, S, Galli, G, Bruni, A, Mancuso, G, Calipari, D, Giuseppe Massimiliano, D, Bernardini, B, Corsini, C, Michele, C, Sara, D, Cagnin, A, Fragiacomo, F, Pompanin, S, Piero, A, Marco, C, Zurlo, A, Guerra, G, Pala, M, Menozzi, L, Gatti, C, Magon, S, Roberto, M, Alfredo, D, Fabio, F, Ruana, T, Elisa, M, Christian, M, Marco, P, Massimo, G, Di Francesco, V, Faccioli, S, Pellizzari, L, Giorgia, F, Barbagallo, G, Lunardelli, M, Martini, E, Ferrari, E, Macchiarulo, M, Corneli, M, Bacci, M, Battaglia, G, Anastasio, L, Lo Storto, M, Seresin, C, Simonato, M, Loreggian, M, Cestonaro, F, Durando, M, Latella, R, Mazzoleni, M, Russo, G, Ponte, M, Valchera, A, Salustri, G, Petritola, D, Costa, A, Sinforiani, E, Cotta, M, Pizio, R, Cester, A, Formilan, M, Pietro, B, Carbone, P, Cazzaniga, I, Appollonio, I, Cereda, D, Stabile, A, Xhani, R, Acampora, R, Tremolizzo, L, Federico, P, Antonio, C, Valerio, P, Cesare, B, Zhirajr, M, Giovanni, V, Maria, A, Mariaelena, S, Bottacchi, E, Bucciantini, E, Di Giovanni, M, Franchi, F, Lucchetti, L, Mariani, C, Grande, G, Rapazzini, P, Marco, M, Romanelli, G, Franco, N, Alessio, M, Nicola, L, Laura, P, Nazario, P, Chiara, G, Soccorso, P, Andrea, S, Luca, B, Francesca, S, Roberto, A, Anna, C, Fugazza, L, Guerrini, C, De Paduanis, G, Iallonardo, L, Palumbo, P, Zuliani, G, Ortolani, B, Capatti, E, Soavi, C, Bianchi, L, Francesconi, D, Miselli, A, Gloria, B, Tommaso, R, Chiara, P, Agata, M, Marco, D, Luca, M, Gianluca, G, Suardi, T, Zaccarini, C, Manuela, R, Mirra, G, Muti, E, Bottura, R, Gianpaolo, M, Secreto, P, Bisio, E, Cecchettani, M, Naldi, T, Pallavicino, A, Pugliese, M, Iozzo, R, Grassi, G, Bombelli, M, Dell'Oro, R, Quarti Trevano, F, Giussani, G, Paternò, G, Contro, E, Mannironi, A, Giorli, E, Oberti, S, Fierro, B, Piccoli, T, Giacalone, F, Mandas, A, Serchisu, L, Costaggiu, D, Pinna, E, Orru, F, Mannai, M, Cordioli, Z, Pelizzari, L, Turcato, E, Arduini, P, Cacace, C, Chiloiro, R, Cimino, R, Ruberto, C, Giovanni, R, Pietro, G, Laura, G, Alberto, C, Carmen, R, Santo, P, Andriolli, A, Burattin, G, Rossi, L, Andreolli Antonino, C, Tezza, F, Maddalena, P, Laura, S, Crippa, P, Aloisio, P, Di Monda, T, Malighetti, A, Galbassini, G, Salutis, D, Ivaldi, C, Russo, A, Bennati, E, Pino, E, Zavarise, G, Pesci, A, Suigo, G, Faverio, P, Andrea, G, Sabrina, P, Zanasi, M, Moniello, G, Rostagno, C, Cartei, A, Polidori, G, Ungar, A, Melis, M, Martellini, E, Enrico, M, Monica, T, Antonella, G, Giovanna, L, Migliorini, M, Caramelli, F, Battiston, B, Berardino, M, Cavallo, S, Alessandro, M, Anna, S, Lombardi, B, D'Ippolito, P, Furini, A, Villani, D, Clara, R, Guarneri, M, Paolucci, S, Bassi, A, Coiro, P, De Angelis, D, Morone, G, Venturiero, V, Palleschi, L, Raganato, P, Di Niro, G, Rosa, C, Loredana, B, Imoscopi, A, Tibaldi, V, Bottignole G, G, Calvi, E, Clementi, C, Zanocchi, M, Agosta, L, Nortarelli, A, Provenzano, G, Mari, D, Romano, F, Rosini, F, Mansi, M, Rossi, S, Geriatria, A, Inzaghi, L, Bonini, G, Rossi, P, Potena, A, Lichii, M, Candiani, T, Grimaldi, W, Bertani, E, Alessandra, P, Calogero, P, Pinto, D, Bernardi, R, Nicolino, F, Galetti, C, Gianstefani, A, Giulia, C, Lorenzo, M, Odetti, P, Monacelli, F, Prefumo, M, Fiammetta, M, Canepa, M, Minaglia, C, Paolisso, G, Rizzo, M, Prestano, R, Dalise, A, Barra, D, Bosco, L, Asprinio, V, Dallape, L, Perina, E, Incalzi, R, Bartoli, I, Pluderi, A, Maina, A, Pecoraro, E, Sciarra, M, Prudente, A, Paola, M, Francesca, M, Manuel, V, Luisella, C, Maria, P, Tina, S, Benini, L, Levato, F, Mhiuta, V, Alius, F, Davidoaia, D, Giardini, V, Garancini, M, Bellamoli, C, Terranova, L, Bozzini, C, Tosoni, P, Provoli, E, Cascone, L, Dioli, A, Ferrarin, G, Bucci, A, Bua, G, Fenu, S, Bianchi, G, Casella, S, Romano, V, Maurizio, P, Mascherona, I, Belotti, G, Cavaliere, S, Cuni, E, Merciuc, N, Oberti, R, Veneziani, S, Capoferri, E, De Bernardi, E, Colombo, K, Bravi, M, Nicoletta, N, D'Arcangelo, P, Montenegro, N, Montanari, R, Lamanna, P, Gasperini, B, Isabella, M, Stefania, D, Gaia, A, Filippo, C, Palama, C, Di Emidio, C, Scarpini, E, Arighi, A, Fumagalli, G, Basilico, P, De Amicis Margherita, M, Marta, M, Diletta, M, Granata, A, Ranalli, C, Cammilli, A, Cavallini, M, Tricca, M, Natella, D, Gabbani, L, Tesi, F, Martella, L, Imbrici, R, Guerrini, G, Scotuzzi, A, Sozzi, F, Valenti, L, Chiarello, A, Monia, M, Pilotto, A, Prete, C, Senesi, B, Meta, A, Pendenza, E, Pasqualetti, G, Polini, A, Tognini, S, Ballino, E, Dell'Aquila, G, Gasparrini, P, Marotti, E, Migale, M, Scrimieri, A, Falsetti, L, Salvi, A, Toigo, G, Ceschia, G, Rosso, A, Tongiorgi, C, Scarpa, C, De Dominicis, L, Pucci, E, Renzi, S, Cartechini, E, Tomassini, P, Del Gobbo, M, Ugenti, F, Romeo, P, Nardelli, A, Lauretani, F, Visioli, S, Montanari, I, Ermini, F, Giordano, A, Pigato, G, Simeone, E, Barbujani, M, Giampieri, M, Amoruso, R, Piccinini, M, Ferrari, C, Gambetti, C, Sfrappini, M, Semeraro, L, Striuli, R, Pelliccioni, G, Marinelli, D, Fabi, K, Rossi, T, Pesallaccia, M, Sabbatini, D, Gobbi, B, Cerqua, R, Tagliani, G, Schlauser, E, Caser, L, Caramello, E, Sandigliano, F, Rosso, G, Ferrari, A, Bendini, C, Luisa, D, Casella, M, Prampolini, R, Scevola, M, Vitale, E, Roberto, B, Carlo, F, Sergio, F, Alberto, S, Daniela, Z, Giulia, B, Serena, G, Michele, B, Maugeri, D, Sorace, R, Anzaldi, M, De Gesu, R, Morrone, G, Davolio, F, Fabbo, A, Palmieri, M, Zoli, M, Forti, P, Pirazzoli, L, Fabbri, E, Terenzi, L, Bergolari, F, Wenter, C, Ruffini, I, Insam, M, Abraham, E, Kirchlechner, C, Cucinotta, D, Antonino, L, Basile, G, Grazia, A, Parise, P, Boccali, A, Amici, S, Gambacorta, M, Lasagni, A, Lovati, R, Giovinazzo, F, Kimak, E, Zappa, P, Medici, F, Lo Castro, M, Mauro, F, De Luca, A, Sancesario, G, Martorana, A, Scaricamazza, B, Toniolo, S, Di Lorenzo, F, Liguori, C, Lasco, A, Vita, N, Giomi, M, Forte, F, Padovani, A, Rozzini, L, Ceraso, A, Salvatore, C, Cottino, M, Vitali, S, Marelli, E, Tripi, G, Miceli, S, Urso, G, Grioni, G, Vezzadini, G, Misaggi, G, Forlani, C, Avanzi, S, Serena, S, Claudia, C, Marilena, V, Alberto, L, Diego, G, Alessandro, G, Iemolo, F, Sanzaro, E, D'Asta, G, Proietto, M, Carnemolla, A, Razza, G, Spadaro, D, Bertolotti, M, Mussi, C, Neviani, F, Roberto, C, Valentina, G, Linda, M, Francesca, V, Tarozzi, A, Balestri, F, Mannarino, G, Bigolari, M, Natale, A, Grassi, S, Bottaro, C, Stefanelli, S, Bovone, U, Tortorolo, U, Quadri, R, Leone, G, Ponzetto, M, Frasson, P, Annoni, G, Confalonieri, R, Corsi, M, Moretti, D, Teruzzi, F, Umidi, S, Mazzola, P, Perego, S, Persico, I, Olivieri, G, Bonfanti, A, Hajnalka, S, Galeazzi, M, Massariello, F, Anzuini, A, Caffarra, P, Barocco, F, Spallazzi, M, Paolo, C, Simonetta, M, Chioatto, P, Bortolamei, S, Soattin, L, Ruotolo, G, Beneamino, B, Giuseppe, B, Bertazzoli, M, Rota, E, Adobati, A, Scarpa, A, Granziera, S, Zuccher, P, Fabbro, A, Zara, D, Lo Nigro, A, Franchetti, L, Toniolo, M, Marcuzzo, C, Rollone, M, Guerriero, F, Sgarlata, C, Masse, A, Zatti, G, Piatti, M, Graci, J, Benati, G, Boschi, F, Biondi, M, Fiumi, N, Erika, T, Locatelli, S, Mauri, S, Beretta, M, Margheritis, L, Desideri, G, Liberatore, E, Carucci, A, Bonino, P, Caput, M, Antonietti, M, Polistena, G, De la Pierre, F, Mari, M, Massignani, P, Tombesi, F, Selvaggio, F, Verbo, B, Bodoni, P, Marchionni, N, Sabatini, T, Mussio, E, Magni, E, Bianchetti, A, Crucitti, A, Titoldini, G, Cossu, B, Fascendini, S, Licini, C, Tomasoni, A, Calderazzo, M, Daniela, T, Valentina, L, Melotti, R, Lilli, A, Buda, S, Adversi, M, Noro, G, Turco, R, Ubezio, M, Mantovani, A, Viola, M, Serrati, C, Pretta, S, Infante, M, Gentile, S, D'Ambrosio, V, Mazzanti, P, Brambilla, C, Sportelli, S, Platto, C, Faraci, B, Quattrocchi, D, Pernigotti, L, Pisu, C, Sicuro, F, Zagnoni, P, Ghiglia, S, Mosca, M, Corazzin, I, Deola, M, Biagini, C, Bencini, F, Cantini, C, Tonon, E, Pierinelli, S, Onofrj, M, Thomas, A, Filomena, B, Bonanni, L, Gabriella, C, Comi, G, Magnani, G, Santangelo, R, Mazzeo, S, Francesca, C, Giordano, C, Roberto, S, Barbieri, C, Giroldi, L, Bandini, F, Masina, M, Malservisi, S, Cicognani, A, Ricca, L, Piccininni, M, Tassinari, T, Brogi, D, Sugo, A, Alessandra, F, Sonia, M, Valerio, V, Andrea, U, Enrico, C, Vera, R, Assunta, S, Gianmaria, Z, Mauro, P, Barone, A, Razzano, M, Giuseppe, I, Angela, B, Francesco, S, Valeria, D, Federico, G, Lucia, P, Antonella, V, Elisabetta, D, Cristina, R, Nadia, C, Maria, S, Luciano, A, Chiara, C, Bini, P, Pignata, M, Enrico, B, Maria, V, Giovanni, C, Giorgio, C, Piera, R, Alberto, Z, Ceccon, A, Magrin, L, Marin, S, Barbara, S, Matteo, M, Caterina, P, Carla, R, Federica, G, Clara, T, Melania, C, Giampaolo, B, Stefano, G, Valeria, G, Lucia, M, Giovambattista, D, Ester, L, Cecilia, C, Maurizio, T, Nadia, B, Grillo, A, Arenare, F, Tonino, M, David, K, Giorgio, V, Ubaldo, B, Vincenzo, S, Stefano, M, Marino, F, Busonera Flavio, M, Paolo, A, Monica, M, Francesco, B, Roberto, F, Paolo, B, Durantemangoni, E, Testoni, M, Fabio, D, Loredana, S, Valeria, S, Fabiano, M, Annabella, D, Salvatore, D, Greco, A, Grazia, D, Daniele, S, Gianluca, R, Renzo, G, Sergio, M, Morena, B, Vitali, M, Marina, P, Paolo, D, Cristina, S, Orlandini, F, La Regina, M, Desiree, A, Mario, B, Paola, P, Padulo, F, Cristina, M, Dario, R, Giancarla, M, Guido, R, Elena, M, Marileda, N, Igor, B, Nicole, B, Elena, R, Paolillo, C, Riccardi, A, Claudia, B, Barbara, R, Silvia, V, Oliver, B, Mauro, C, Eleonora, M, Giuseppe, P, Rosaria, T, Maria, C, Davide, D, Stefania, C, Massimo, P, Luca, S, Martina, D, Paola, V, Lia, S, Sandro, C, Valentina, D, Erminia, B, Paola, C, Romina, R, Minisola, S, Luciano, C, Pasquale, A, Ilaria, L, Guglielmo, S, Marco, E, Sara, R, Paola, A, Claudio, A, Francesco, R, Alessandro, C, Simona, M, Lara, F, Paola, R, Simonetta, C, Antonella, C, Generoso, U, Fernando, G, Giuliano, C, Emanuela, S, Mariolina, S, Alessandro, D, Giulia, L, Famularo, S, Sandini, M, Pinotti, E, Gianotti, L, Antonella, B, Giulia, P, Sante, G, Rossi, A, Rubele, S, Sant, S, Marco, V, Danila, C, Fabio, R, Bandirali, M, Nicoletta, C, Laura, B, Paolo, T, Luciano, T, Leonello, A, Margherita, S, Pierluigi, D, Laura, R, Fabiana, T, Giovanna, C, Antonino, A, Felice, C, Danilo, F, Giovanna, D, Francesco, L, Salini, S, Giorgetta, C, Giovanni, G, Gerardo, B, Silvio, R, Letizia, S, Davide, B, Rosaria, R, Maria, D, Raffaele, P, Palmieri, V, Palasciano, G, Belfiore, A, Portincasa, P, Carlo, S, Alessia, D, Valiani, V, Carolina, B, Tiziana, C, Paola, T, Ugo, P, Giacomo, P, Castellano, M, Anna, G, Elisa, C, Federica, C, Antonietta, C, Luigi, M, Fabio, L, Salvatore, B, Gelosa, G, Viviana, A, Piras, V, Andrea, C, Alessandra, B, Coen, D, Magliola, R, Milanesio, D, Muzzulini, C, Paolo, F, Marinella, T, Sofia, C, Marta, B, Siano, P, Capo, G, Napoletano, R, Cecilia, P, Mancini, C, Del Buono, C, De Bartolomeo, G, Addolorata, M, Carmen, C, Moschettini, G, Franco, M, Daniela, R, D'Amico, G, Mirella, P, Endrizzi, C, Trotta, L, Ciarambino, T, Orazio, Z, Emanuela, T, Marta, S, Thomas, F, Giacomo, T, Ignazio, D, Andrea, B, Giuseppe, O, Emanuela, F, Serena, A, Elena, D, Serena, B, Erika, N, Elena, S, Manuela, P, Francesca, A, Angelo, T, Di Santo SG, Rizzo, Maria Rosaria, Paolisso, Giuseppe, and Italian Study Group on Delirium, (ISGoD).

Subjects
Rehabilitation hospital, medicine.medical_specialty, Urinary system, Socio-culturale, dementia, elderly, Motor subtypes of delirium, Aged, Cross-Sectional Studies, Humans, Inpatients, Italy, Delirium, Dementia, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, mental disorders, medicine, Motor subtypes of delirium, dementia, elderly, dementia, elderly, Motor subtypes of delirium, 030212 general & internal medicine, LS4_4, Medical prescription, General Nursing, Psychomotor learning, business.industry, Health Policy, Medical record, Memantine, General Medicine, medicine.disease, Settore MED/26 - NEUROLOGIA, Geriatrics and Gerontology, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Objectives Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design This is a cross-sectional study nested in the "Delirium Day" study, a nationwide Italian point-prevalence study. Setting and participants Older patients admitted to 205 acute and 92 rehabilitation hospital wards. Measures Delirium was evaluated with the 4-AT and the motor subtypes with the Delirium Motor Subtype Scale. Dementia was defined by the presence of a documented diagnosis in the medical records and/or prescription of acetylcholinesterase inhibitors or memantine prior to admission. Results Of the 1057 patients with dementia, 35% had delirium, with 25.6% hyperactive, 33.1% hypoactive, 34.5% mixed, and 6.7% nonmotor subtype. There were higher odds of having venous catheters in the hypoactive (OR 1.82, 95% CI 1.18-2.81) and mixed type of delirium (OR 2.23, CI 1.43-3.46), whereas higher odds of urinary catheters in the hypoactive (OR 2.91, CI 1.92-4.39), hyperactive (OR 1.99, CI 1.23-3.21), and mixed types of delirium (OR 2.05, CI 1.36-3.07). We found higher odds of antipsychotics both in the hyperactive (OR 2.87, CI 1.81-4.54) and mixed subtype (OR 1.84, CI 1.24-2.75), whereas higher odds of antibiotics was present only in the mixed subtype (OR 1.91, CI 1.26-2.87). Conclusions and implications In patients with dementia, the mixed delirium subtype is the most prevalent followed by the hypoactive, hyperactive, and nonmotor subtype. Motor subtypes of delirium may be triggered by clinical factors, including the use of venous and urinary catheters, and the use of antipsychotics. Future studies are necessary to provide further insights on the possible pathophysiology of delirium in patients with dementia and to address the optimization of the management of potential risk factors.

Published
2020

46. Dry Ashing for Signal Enhancement in Laser-Induced Breakdown Spectroscopy (LIBS)

Author

José Anchieta Gomes Neto, Dário Santos Júnior, Giorgio S. Senesi, Edilene Cristina Ferreira, Tiago Varão Silva, Carla Pereira de Morais, Maisa Cristina Lázaro, Universidade Estadual Paulista (Unesp), CNR, and Universidade de São Paulo (USP)

Subjects
Clinical Biochemistry, 02 engineering and technology, 01 natural sciences, Biochemistry, Analytical Chemistry, Dry ashing, Dry heating, Electrochemistry, Laser-induced breakdown spectroscopy, Spectroscopy, business.industry, Chemistry, 010401 analytical chemistry, Biochemistry (medical), sensitivity, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Signal enhancement, Ashing, Optoelectronics, dry heating, laser-induced breakdown spectroscopy (LIBS), 0210 nano-technology, business, Sensitivity (electronics)
Abstract

Made available in DSpace on 2021-06-25T11:05:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Limited sensitivities of some laser-induced breakdown spectroscopy (LIBS) instruments may impair some applications. Although this drawback can be minimized by instrumental improvements, the complexity of operations and cost increases. In this work the principle of conventional dry ashing for sample preparation was evaluated as a simple and low-cost alternative to improve the sensitivity of LIBS analysis. Botanical, agronomic and industrial samples were analyzed. Samples were dry heated and their LIBS emission signals were evaluated. The results suggest the dry heating caused structural changes in samples providing greater availability of the analyte, which resulted in the enhancement of the signals. As proof of concept, the strategy was applied for Sr determination in plant leaves. Two Sr emission lines, enhanced after sample dry ashing were used. The developed methods showed similar performance featuring a good linear range (10 to 70 μg g−1) with coefficient of correlations higher than 0.99. Additionally, the accurate determination of Sr in apple and peach leaves standard materials was achieved. Department of Analytical Physical-Chemical and Inorganic Chemistry São Paulo State University - UNESP Istituto per la Scienza e Tecnologia dei Plasmi (ISTP) Sede di Bari CNR Exact and Earth Sciences Department Federal University of São Paulo - UNIFESP Department of Analytical Physical-Chemical and Inorganic Chemistry São Paulo State University - UNESP

Published
2020
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47. Neutronic Calculations for the Shielding Design of the VESPA Instrument at the European Spallation Source

Author

V. Santoro, R. G. Agostino, Roberto Senesi, Monika Hartl, G. Scionti, Daniele Colognesi, and Giuseppe Gorini

Subjects
010302 applied physics, Neutron transport, Materials science, Proton, Astrophysics::High Energy Astrophysical Phenomena, Nuclear engineering, Nuclear Theory, 02 engineering and technology, Radiation, 021001 nanoscience & nanotechnology, 01 natural sciences, Neutron temperature, Surfaces, Coatings and Films, 0103 physical sciences, Electromagnetic shielding, Physics::Accelerator Physics, Neutron, Spallation, Nuclear Experiment, 0210 nano-technology, Beam (structure)
Abstract

The European Spallation Source is being built in Lund, Sweden and it’s planned to be the brightest pulsed spallation source for thermal and cold neutrons (

Published
2020
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48. K-wire fixation vs 23-gauge percutaneous hand- crossed hypodermic needle for the treatment of distal phalangeal fractures

Author

Antonio Gigante, Letizia Senesi, Michele Riccio, Pier Paolo Pangrazi, Marialuisa De Francesco, Andrea Marchesini, and Francesco De Francesco

Subjects
medicine.medical_specialty, K-wire fixation, Percutaneous, lcsh:Diseases of the musculoskeletal system, Radiography, Time to union, Fracture Fixation, Internal, Fractures, Bone, 03 medical and health sciences, Fixation (surgical), 0302 clinical medicine, Rheumatology, Statistical significance, Finger Injuries, medicine, Humans, Orthopedics and Sports Medicine, Range of Motion, Articular, Range of motion, Retrospective Studies, Hypodermic needle, 030203 arthritis & rheumatology, 030222 orthopedics, business.industry, Phalanx, Surgery, Treatment Outcome, Needles, Needle fixation, Orthopedic surgery, lcsh:RC925-935, business, Bone Wires, Research Article, Distal interphalangeal fracture
Abstract

Background Distal Phalanx (DP) fractures are the most common hand injuries. Bone fixation associated with soft tissue reconstruction, is often required to ensure more effective outcomes. The aim of the present study is to compare functional outcomes of DP fractures surgically treated with crossed manual drilled 23 Gauge needles vs crossed Kirschner-wires (k-wire). Methods Clinical data included analysis of patient demographics, range of motion (ROM), and complications. Radiographic assessment considered fracture type, location, fracture displacement, and radiographic union. Functional outcomes analysis was performed.The statistical significance was assessed at the level of probability lower than 5%. Results A total of 60 patients from 2012 to 2015 were retrospectively enrolled and among them 12 patients suffering from diabetes or current smokers. A total of 60 DP fractures were treated, 32 with needles (group A) and 28 with k-wire fixation (group B). Time to union, showed in different time points, was significantly lower in group A (≤ 40 days, p = 0.023*) compared to group B. ROM of the distal interphalangeal joint at six months follow-up was 60° in group A and 40° in group B. A significant improvement was observed (p = 0.001*) in the 23 G needle treated group. Functional outcome analysis showed that VAS was significantly lower in group A compared to group B (p = 0.023*). Conclusion Our study showed that the 23 G needle yielded satisfactory results in terms of time to union and range of motion compared to k-wire fixation especially for tuft and shaft DP fractures. Therefore, should be a valid alternative to k-wire fixation in selected patients.

Published
2020
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49. Carbon Nanotube-Based Stretchable Hybrid Material Film for Electronic Devices and Applications

Author

Anderson Gaglione, Valerio Scacco, Anna Prioriello, Federica Mastroiacovo, Daniele Mirabile Gattia, Luigi Pavone, Roberto Senesi, Piero Morales, Laura Fazi, and Slavianka Moyanova

Subjects
chemistry.chemical_classification, Materials science, Biocompatibility, Composite number, Biomedical Engineering, Bioengineering, Nanotechnology, General Chemistry, Polymer, Carbon nanotube, Condensed Matter Physics, law.invention, Characterization (materials science), chemistry, law, Electrode, General Materials Science, Hybrid material, Electrical conductor
Abstract

To meet the increasing demand, for stretchable conductive materials in a wide range of applications, innovative conductors based on single wall carbon nanotubes (SWCNT) self-grafted on different polymer films, are assembled. Aiming at a simple technology for flexible and stretchable electronic devices, and contrary to what commonly reported for carbon nanotubes (CNT), no chemical functionalization of SWCNT is necessary for stable grafting onto several polymeric surfaces. The novelty and functionality of our composite materials stand in the synergy among the intrinsic biocompatibility of CNT, a fully inert material, their electrical conductivity, and the stretchable-viscoelastic properties of the polymer-nanotube bundles composites. Electrical characterization of both unstretched and strongly stretched planar film conductors is provided, demonstrating the use of this new composite material for technological application. Also, an insight into the mechanisms of strong adhesion to the polymer is obtained by scanning electron microscopy (SEM) of the surface composite. As an example of technological application of such stretchable circuitry, the electrical functionality of a carbon nanotube-based six-sensor (electrode) grid is used to record subdural electrocorticograms in freely-moving laboratory rats over approximately three months.

Published
2020
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50. Adapting and implementing training, guidelines and treatment cards to improve primary care-based hypertension and diabetes management in a fragile context: results of a feasibility study in Sierra Leone

Author

Lizzie Caperon, Guanyang Zou, John Walley, Sophie Witter, Haja Wurie, Reynold G. B. Senesi, and Kiran Cheedella

Subjects
Male, medicine.medical_specialty, 030231 tropical medicine, education, Fragile setting, Context (language use), Blood Pressure, Sierra leone, Sierra Leone, 03 medical and health sciences, 0302 clinical medicine, Mentorship, Nursing, Diabetes management, medicine, Diabetes Mellitus, Humans, 030212 general & internal medicine, Non-communicable diseases, Noncommunicable Diseases, Feasibility assessment, Community Health Workers, Medical Assistance, Primary Health Care, business.industry, Public health, lcsh:Public aspects of medicine, Mentors, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Middle Aged, Primary care strengthening, Community health, Hypertension, Feasibility Studies, Female, Thematic analysis, Biostatistics, business, Delivery of Health Care, Research Article, Program Evaluation
Abstract

Background Sierra Leone, a fragile country, is facing an increasingly significant burden of non-communicable diseases (NCDs). Facilitated by an international partnership, a project was developed to adapt and pilot desktop guidelines and other clinical support tools to strengthen primary care-based hypertension and diabetes diagnosis and management in Bombali district, Sierra Leone between 2018 and 2019. This study assesses the feasibility of the project through analysis of the processes of intervention adaptation and development, delivery of training and implementation of a care improvement package and preliminary outcomes of the intervention. Methods A mixed-method approach was used for the assessment, including 51 semi-structured interviews, review of routine treatment cards (retrieved for newly registered hypertensive and diabetic patients from June 2018 to March 2019 followed up for three months) and mentoring data, and observation of training. Thematic analysis was used for qualitative data and descriptive trend analysis and t-test was used for quantitative data, wherever appropriate. Results A Technical Working Group, established at district and national level, helped to adapt and develop the context-specific desktop guidelines for clinical management and lifestyle interventions and associated training curriculum and modules for community health officers (CHOs). Following a four-day training of CHOs, focusing on communication skills, diagnosis and management of hypertension and diabetes, and thanks to a CHO-based mentorship strategy, there was observed improvement of NCD knowledge and care processes regarding diagnosis, treatment, lifestyle education and follow up. The intervention significantly improved the average diastolic blood pressure of hypertensive patients (n = 50) three months into treatment (98 mmHg at baseline vs. 86 mmHg in Month 3, P = 0.001). However, health systems barriers typical of fragile settings, such as cost of transport and medication for patients and lack of supply of medications and treatment equipment in facilities, hindered the optimal delivery of care for hypertensive and diabetic patients. Conclusion Our study suggests the potential feasibility of this approach to strengthening primary care delivery of NCDs in fragile contexts. However, the approach needs to be built into routine supervision and pre-service training to be sustained. Key barriers in the health system and at community level also need to be addressed.

Published
2020
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