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2. Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders

Author

Godin, Ophélia, Leboyer, Marion, Grillault Laroche, Diane, Aubin, Valérie, Belzeaux, Raoul, Courtet, Philippe, Dubertret, Caroline, Gard, Sébastien, Haffen, Emmanuel, Olie, Emilie, Polosan, Mircea, Roux, Paul, Samalin, Ludovic, Schwan, Raymund, Bellivier, Frank, Etain, Bruno, IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Princesse Grace, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Centre hospitalier Charles Perrens [Bordeaux], Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Universitaire [Grenoble] (CHU), [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Centre Psychothérapique de Nancy [Laxou] (CPN), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Hôpital Lariboisière-Fernand-Widal [APHP]

Subjects
medical comorbidities, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, childhood maltreatment, Bipolar disorders, health, morbidity
Abstract

International audience; Background: Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature.Methods: We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders.Results: One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset.Conclusions: This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated.

Published
2023

3. Definition of early age at onset in bipolar disorder according to distinctive neurodevelopmental pathways:Insights from the FACE-BD study

Author

Corponi, Filippo, Lefrere, Antoine, Leboyer, Marion, Bellivier, Frank, Godin, Ophelia, Loftus, Josephine, Courtet, Philippe, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Samalin, Ludovic, Olié, Émilie, Etain, Bruno, Seriès, Peggy, Belzeaux, Raoul, University of Edinburgh, Assistance Publique - Hôpitaux de Marseille (APHM), Fondation FondaMental [Créteil], Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Princesse Grace, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), CHU Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Psychothérapique de Nancy [Laxou] (CPN), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Pôle Digestif [CHRU Montpellier]

Subjects
bipolar disorder, machine learning, neurodevelopment, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Age at onset, age at onset
Abstract

BackgroundConverging evidence suggests that a subgroup of bipolar disorder (BD) with an early age at onset (AAO) may develop from aberrant neurodevelopment. However, the definition of early AAO remains unprecise. We thus tested which age cut-off for early AAO best corresponds to distinguishable neurodevelopmental pathways.MethodsWe analyzed data from the FondaMental Advanced Center of Expertise-Bipolar Disorder cohort, a naturalistic sample of 4421 patients. First, a supervised learning framework was applied in binary classification experiments using neurodevelopmental history to predict early AAO, defined either with Gaussian mixture models (GMM) clustering or with each of the different cut-offs in the range 14 to 25 years. Second, an unsupervised learning approach was used to find clusters based on neurodevelopmental factors and to examine the overlap between such data-driven groups and definitions of early AAO used for supervised learning.ResultsA young cut-off, i.e. 14 up to 16 years, induced higher separability [mean nested cross-validation test AUROC = 0.7327 (± 0.0169) for ⩽16 years]. Predictive performance deteriorated increasing the cut-off or setting early AAO with GMM. Similarly, defining early AAO below 17 years was associated with a higher degree of overlap with data-driven clusters (Normalized Mutual Information = 0.41 for ⩽17 years) relatively to other definitions.ConclusionsEarly AAO best captures distinctive neurodevelopmental patterns when defined as ⩽17 years. GMM-based definition of early AAO falls short of mapping to highly distinguishable neurodevelopmental pathways. These results should be used to improve patients' stratification in future studies of BD pathophysiology and biomarkers.

Published
2023

4. Variations of retinal dysfunctions with the level of cannabis use in regular users: Toward a better understanding of cannabis use pathophysiology

Author

Schwitzer, Thomas, Moreno-Zaragoza, Aldo, Dramé, Louis, Schwan, Raymund, Angioi-Duprez, Karine, Albuisson, Eliane, and Laprévote, Vincent

Subjects
Psychiatry and Mental health
Abstract

The impact of regular cannabis use on retinal function has already been studied using flash (fERG) and pattern (PERG) electroretinogram. Delayed ganglion and bipolar cells responses were observed as showed by increased peak time of PERG N95 and fERG b-wave recorded in photopic condition. Hypoactivity of amacrine cells was also showed by decreased amplitudes of oscillatory potentials (OPs). However, it is unknown how these retinal anomalies evolve according to the level of cannabis use in cannabis users. The aim of this study was to longitudinally assess the retinal function during a treatment aiming to reduce cannabis use. We recorded PERG and fERG in 40 regular cannabis users receiving either an 8 weeks mindfulness-based relapse prevention program or an 8 weeks treatment-as-usual therapy. ERGs were recorded before treatment, at the end of it, and 4 weeks afterward. We found reduced peak times in PERG N95 and fERG b-wave (p = 0.032 and p = 0.024: Dunn’s post-hoc test) recorded at week 8 and increased amplitudes in OP2 and OP3 (p = 0.012 and p = 0.030: Dunn’s post-hoc test) recorded at week 12 in users with decreased cannabis use. These results support variations of retinal anomalies with the level of cannabis use, implying that reduction of cannabis use could restore retinal function in regular users.

Published
2022

5. Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort

Author

Mallet, Jasmina, Godin, Ophélia, Mazer, Nicolas, Le Strat, Yann, Bellivier, Frank, Belzeaux, Raoul, Etain, Bruno, Fond, Guillaume, Gard, Sébastien, Henry, Chantal, Leboyer, Marion, Llorca, Pierre-Michel, Loftus, Joséphine, Olié, Emilie, Passerieux, Christine, Polosan, Mircea, Schwan, Raymund, Roux, Paul, Dubertret, Caroline, Barteau, V., Bensalem, S., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Drancourt, N., Sanchez, J., Saliou, E., Hebbache, C., Petrucci, J., Willaume, L., Bourdin, E., Carminati, M., Marlinge, E., Meheust, J., Antoniol, B., Desage, A., Jutant, A., Mbailara, K., Minois, I., Zanouy, L., Abettan, C., Bardin, L., Cazals, A., Courtet, P., Deffinis, B., Ducasse, D., Gachet, M., Henrion, A., Martinerie, E., Molière, F., Noisette, B., Tarquini, G., Azorin, J., Correard, N., Muraccioli, I., Groppi, F., Lescalier, L., Rebattu, M., Viglianese, N., Cohen, R., Kahn, J., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Fredembach, B., Suisse, A., Tassan, L., Pouchon, A., Cannavo, A., Crea, A., Feuga, V., Galliot, A., Kayser, N., Aubin, V., Cussac, I., Dupont, M., Medecin, I., Bing, A., Samalin, L., Foures, L, Lacelle, D., Pires, S., Doriat, C., Blanc, O., Fondation FondaMental [Créteil], Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), IMRB - 'Biologie du système neuromusculaire' [Créteil] (U955 Inserm - UPEC), École nationale vétérinaire - Alfort (ENVA)-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Assistance Publique - Hôpitaux de Marseille (APHM), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), CHU Bordeaux [Bordeaux], GHU AP-HP Centre Université de Paris, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), CHU Clermont-Ferrand, Centre Hospitalier Princesse Grace, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Universitaire [Grenoble] (CHU), [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), This work was funded by AP-HP (Assistance Publique des Hôpitaux de Paris), Fondation FondaMental (RTRS Santé Mentale), by the 'Investissements d’Avenir' programs managed by the Agence Nationale de Recherche (ANR), France under references ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut National de la Santé et de la Recherche Médicale)., ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010), ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), BOHAUD, FRANCOISE, Cohortes - FondaMental-Cohortes - - Psy-COH2010 - ANR-10-COHO-0010 - COHO - VALID, and Sorbonne Universités à Paris pour l'Enseignement et la Recherche - - SUPER2011 - ANR-11-IDEX-0004 - IDEX - VALID

Subjects
Pediatrics, medicine.medical_specialty, medicine.drug_class, Substance-Related Disorders, Bipolar disorder, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Functional Laterality, Dyslexia, Cognition, medicine, Humans, Pharmacology (medical), [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Child, Biological Psychiatry, Handedness, business.industry, Laterality, Neuropsychology, Mood stabilizer, General Medicine, medicine.disease, Substance abuse, Psychiatry and Mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Cohort, Language disorders, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], business, Neurocognitive, Body mass index
Abstract

International audience; Objectives: High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.Methods: We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.Results: The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (p < 0.01), and dyslexia and dysphasia for NRH (p = 0.01 and p = 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96-0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03-1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all p < 0.01) and less mood stabilizer prescription (p = 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index.Conclusions: Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.

Published
2021

6. Suppl_Table_1 – Supplemental material for Characterization of depressed bipolar patients with current suicidal ideation

Author

Nobile, Bénédicte, Dubois, Jonathan, Aouizerate, Bruno, Aubin, Valerie, Loftus, Joséphine, Bellivier, Frank, Belzeaux, Raoul, Dubertret, Caroline, Gard, Sebastien, Haffen, Emmanuel, Schwan, Raymund, Pierre-Michel Llorca, Passerieux, Christine, Roux, Paul, Polosan, Mircea, Etain, Bruno, Leboyer, Marion, Courtet, Philippe, and Olié, Emilie

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, Suppl_Table_1 for Characterization of depressed bipolar patients with current suicidal ideation by Bénédicte Nobile, Jonathan Dubois, Bruno Aouizerate, Valerie Aubin, Joséphine Loftus, Frank Bellivier, Raoul Belzeaux, Caroline Dubertret, Sebastien Gard, Emmanuel Haffen, Raymund Schwan, Pierre-Michel Llorca, Christine Passerieux, Paul Roux, Mircea Polosan, Bruno Etain, Marion Leboyer, Philippe Courtet and Emilie Olié in Australian & New Zealand Journal of Psychiatry

Published
2020
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7. Dispositif d'exploration du système visuel

Author

SCHWAN, Raymund, Louis Dorr, Valérie, Schwitzer, Thomas, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), and Université de Lorraine (UL)

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing
Abstract

La présente invention concerne un dispositif d'exploration du système visuel, comprenant un équipement de visualisation portable (1) comportant au moins un écran de visualisation (11, 12) destiné à être placé face à au moins un œil d'une personne. Selon l'invention, l'équipement de visualisation (1) comprend des lèvres d'obturation (2, 21) entourant les écrans de visualisation (11, 12), et présentant un bord libre destiné à être appliqué contre la peau de la personne, ce bord libre comprenant au moins une électrode (31, 32, 33) de mesure du potentiel électrique. Le dispositif comprend également au moins une électrode libre (41, 42) de mesure du potentiel électrique, reliée, par fil de connexion (410, 420), à un connecteur (22) porté par l'équipement de visualisation (1), entre l'un des écrans de visualisation (11, 12) et le bord libre des lèvres d'obturation (2, 21) entourant cet écran.

Published
2019

9. Retinal ganglion cells dysfunction in schizophrenia patients with visual hallucinations

Author

Bernardin, Florent, Schwan, Raymund, Schwitzer, Thomas, Laprevote, Vincent, Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg-Université de Strasbourg (UNISTRA)

Subjects
ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2017
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10. Pourquoi et comment soigner plus précocement les troubles psychotiques ?

Author

Laprevote, Vincent, Heitz, Ulrike, Di Patrizio, Paolo, Studerus, Erich, Ligier, Fabienne, Schwitzer, Thomas, Schwan, Raymund, Riecher-Rössler, Anita, Centre Psychothérapique de Nancy (CPN), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Universitäre Psychiatrische Kliniken Basel, Faculté de Médecine [Nancy], and Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC)

Subjects
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Abstract

International audience; Chronic psychosis, as for instance schizophrenia, usually begins in young adulthood and may cause severe disability. It causes a mean loss of life expectancy of 22 years.Actual models of psychosis do not trace the beginning of psychosis to the first franc psychotic episode only, but to earlier symptoms.In a classical health system only considering the first psychotic episode, the mean duration of untreated illness (DUI) can last several years. Yet this DUI has a direct impact on the prognosis of the disease.Actual international recommendations prescribe to early detect and treat at risk mental states of psychosis, thus reducing DUI. Such an attitude also helps the patient to integrate care in a moment where she/he is fully in condition to consent and to adhere.Generalist practitioners are crucial actors of early detection. We describe here simple and standardized tools helping early detection of high-risk mental states of psychosis in primary care and the appropriate attitude to do it properly.Numerous countries have developed early detection and treatment centers for psychosis. It has been established that such interventions clearly decrease the risk of transition towards chronic psychosis and improve the prognosis.These recent data about early detection and intervention in psychosis are a major step forward in psychiatry practice. It is now necessary to largely develop such actions in France.

Published
2016

11. Retinal anomalies in schizophrenia patients and regular cannabis users: a potential way to a biological marker?

Author

Schwitzer, Thomas, Schwan, Raymund, Giersch, Anne, Laprevote, Vincent, Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg-Université de Strasbourg (UNISTRA)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Schwitzer T, Schwan R, Giersch A, Laprevote V. Retinal anomalies in schizophrenia patients and regular cannabis users: a potential way to a biological marker? 5th Biennial Schizophrenia International Research Society Conference (SIRS), Florence, Italia, 2-6 avril 2016.; International audience

Published
2016

12. Liens entre stratégies de coping, anxiété-dépression et qualité de vie dans la dépendance aux substances psychoactives

Author

Bourion-Bedes, Stéphanie, Baumann, Cédric, Ciobanu, Iulia, Viennet, Sarah, Di Patrizio, Paolo, BENSSOULA, M, Schwan, Raymund, Di Patrizio, Paolo, and Université de Lorraine (UL)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

13. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications

Author

Schwitzer, Thomas, Schwan, Raymund, Angioi-Duprez, Karine, Giersch, Anne, and Laprevote, Vincent

Subjects
Article Subject, lipids (amino acids, peptides, and proteins)
Abstract

Cannabis is one of the most prevalent drugs used in industrialized countries. The main effects of Cannabis are mediated by two major exogenous cannabinoids: ∆9-tetrahydroxycannabinol and cannabidiol. They act on specific endocannabinoid receptors, especially types 1 and 2. Mammals are endowed with a functional cannabinoid system including cannabinoid receptors, ligands, and enzymes. This endocannabinoid signaling pathway is involved in both physiological and pathophysiological conditions with a main role in the biology of the central nervous system. As the retina is a part of the central nervous system due to its embryonic origin, we aim at providing the relevance of studying the endocannabinoid system in the retina. Here, we review the distribution of the cannabinoid receptors, ligands, and enzymes in the retina and focus on the role of the cannabinoid system in retinal neurobiology. This review describes the presence of the cannabinoid system in critical stages of retinal processing and its broad involvement in retinal neurotransmission, neuroplasticity, and neuroprotection. Accordingly, we support the use of synthetic cannabinoids as new neuroprotective drugs to prevent and treat retinal diseases. Finally, we argue for the relevance of functional retinal measures in cannabis users to evaluate the impact of cannabis use on human retinal processing.

Published
2016
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14. Déterminants de la satisfaction des soins dans la prise en charge ambulatoire de patients dépendants aux substances psychoactives

Author

Bourion-Bedes, Stéphanie, Baumann, Cédric, Viennet, Sarah, Di Patrizio, Paolo, Lacroix, Noémie, Schwan, Raymund, Université de Lorraine (UL), and Di Patrizio, Paolo

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

15. Combination of classical test theory (CTT) and item response theory (IRT) analysis to study the psychometric properties of the French version of the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF)

Author

Epstein, J, Bourion-Bédès, Stéphanie, Schwan, Raymund, Epstein, Jonathan, Laprevote, Vincent, Bédès, Alex, Bonnet, Jean-Louis, Baumann, Cédric, Service médico-psychologique régional - Metz, Centre d'Addictovigilance de Nancy [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Epidémiologie Clinique (CIC-EC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biologie Cellulaire (LBC), Université d'Auvergne - Clermont-Ferrand I (UdA), Centre d'Addictovigilance de Nancy [CHRU Nancy] (CEIP-A Nancy), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Centre Psychothérapeutique, Centre de Soins, d'Accompagnement et de Prévention en Addictologie, Centre de soin, d'accompagnement et de prévention en addictologie - Cantal (C.S.A.P.A. 15 Aurillac), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Centre d'Epidémiologie Clinique ( CIC-EC ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire de Biologie Cellulaire ( LBC ), and Université d'Auvergne - Clermont-Ferrand I ( UdA )

Subjects
Male, Psychometrics, Personal Satisfaction, MESH : Cross-Sectional Studies, Quality of life, Surveys and Questionnaires, Item response theory, MESH : Female, Reliability (statistics), ComputingMilieux_MISCELLANEOUS, Language, MESH : Personal Satisfaction, MESH: Middle Aged, MESH : Psychometrics, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH : Adult, Middle Aged, Confirmatory factor analysis, Test (assessment), MESH: Reproducibility of Results, MESH: Substance-Related Disorders, MESH: Language, Female, France, Psychology, MESH : Surveys and Questionnaires, Clinical psychology, MESH : Substance-Related Disorders, Adult, Substance-Related Disorders, MESH : Male, MESH: Factor Analysis, Statistical, MESH : Factor Analysis, Statistical, Classical test theory, MESH: Cross-Sectional Studies, MESH: Psychometrics, MESH : Language, MESH: Personal Satisfaction, Humans, MESH : Middle Aged, MESH: Surveys and Questionnaires, MESH : France, MESH: Humans, MESH : Reproducibility of Results, MESH : Humans, Public Health, Environmental and Occupational Health, Construct validity, Reproducibility of Results, MESH: Quality of Life, MESH: Adult, MESH : Quality of Life, MESH: Male, MESH: France, Cross-Sectional Studies, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Quality of Life, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Factor Analysis, Statistical, MESH: Female
Abstract

International audience; OBJECTIVE:The study aimed to examine the construct validity and reliability of the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) according to both classical test and item response theories.METHOD:The psychometric properties of the French version of this instrument were investigated in a cross-sectional, multicenter study. A total of 124 outpatients with a substance dependence diagnosis participated in the study. Psychometric evaluation included descriptive analysis, internal consistency, test-retest reliability, and validity. The dimensionality of the instrument was explored using a combination of the classical test, confirmatory factor analysis (CFA), and an item response theory analysis, the Person Separation Index (PSI), in a complementary manner.RESULTS:The results of the Q-LES-Q-SF revealed that the questionnaire was easy to administer and the acceptability was good. The internal consistency and the test-retest reliability were 0.9 and 0.88, respectively. All items were significantly correlated with the total score and the SF-12 used in the study. The CFA with one factor model was good, and for the unidimensional construct, the PSI was found to be 0.902.CONCLUSION:The French version of the Q-LES-Q-SF yielded valid and reliable clinical assessments of the quality of life for future research and clinical practice involving French substance abusers. In response to recent questioning regarding the unidimensionality or bidimensionality of the instrument and according to the underlying theoretical unidimensional construct used for its development, this study suggests the Q-LES-Q-SF as a one-dimension questionnaire in French QoL studies.

Published
2015

16. Crises psychogènes non épileptiques

Author

Hingray, Coraline, Maillard, Louis, Schwan, Raymund, Reuber, Markus, Maquin, Didier, Pierre Thomas and Arnaud Biraben, Centre de Soins, d'Accompagnement et de Prévention en Addictologie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Recherche en Automatique de Nancy (CRAN), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)

Subjects
[SPI.AUTO] Engineering Sciences [physics]/Automatic, ComputingMilieux_MISCELLANEOUS, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract

National audience

Published
2015

17. Déterminants de la satisfaction des soins dans la prise en charge ambulatoire de patients dépendants aux substances psychoactives. « Les addictions aujourd’hui et demain »

Author

Bourion-Bedes, Stéphanie, Baumann, Cédric, Viennet, Sarah, Di Patrizio, Paolo, Lacroix, Noémie, Schwan, Raymund, Di Patrizio, Paolo, and Université de Lorraine (UL)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

18. Influence of spatial frequencies on early stages of face processing: an event-related potentials study

Author

Jeantet, Coline, Laprevote, Vincent, Schwan, Raymund, Caharel , Stéphanie, Lighezzolo-Alnot, Joëlle, Lighezzolo-Alnot, Joëlle, Laboratoire de psychologie de l'interaction et des relations intersubjectives (INTERPSY), Université de Lorraine (UL), Centre de Soins, d'Accompagnement et de Prévention en Addictologie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), and Centre Psychothérapeutique

Subjects
[SHS.PSY] Humanities and Social Sciences/Psychology, [SCCO.PSYC]Cognitive science/Psychology, [SCCO.PSYC] Cognitive science/Psychology, [SHS.PSY]Humanities and Social Sciences/Psychology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

19. Low Spatial Frequency Bias in Schizophrenia is Not Face Specific: When the Integration of Coarse and Fine Information Fails

Author

Laprevote, Vincent, Oliva, Aude, Ternois, Anne-Sophie, Schwan, Raymund, Thomas, Pierre, and Boucart, Muriel

Subjects
schizophrenia, vision, magnocellular, Psychology, spatial frequency, hybrid image, General Psychology, Original Research, object
Abstract

Studies have shown that patients with schizophrenia exhibit visual processing impairments, particularly regarding the processing of spatial frequencies. In a previous work, we found that, compared to healthy volunteers, patients were biased toward low spatial frequencies (LSF) to identify facial expression at a glance. Given the ubiquity of faces in visual perception, it remains an open question whether the LSF bias is face specific or also occurs with other visual objects. Here, 15 patients with schizophrenia and 11 healthy control adults performed a categorization task with hybrid stimuli. These stimuli were single images consisting of two different objects, a fruit and an animal, each in a specific spatial frequency range, either low (LSF) or high (HSF). Observers were asked to report if they saw an animal or a fruit. The reported category demonstrated which spatial scale was preferentially perceived in each trial. In a control experiment, participants performed the same task but with images of only a single object, either a LSF or HSF filtered animal or fruit, to verify that participants could perceive both HSF or LSF when presented in isolation. The results on the categorization task showed that patients chose more frequently LSF with hybrid stimuli compared to healthy controls. However, both populations performed equally well with HSF and LSF filtered pictures in the control experiment, demonstrating that the LSF preference found with hybrid stimuli in patients was not due to an inability to perceive HSF. The LSF preference found in schizophrenia confirms our previous study conducted with faces, and shows that this LSF bias generalizes to other categories of objects. When a broad range of spatial frequencies are present in the image, as in normal conditions of viewing, patients preferentially rely on coarse visual information contained in LSF. This result may be interpreted as a dysfunction of the guidance of HSF processing by LSF processing.

Published
2013
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20. Neurosurgery in Parkinson's disease: Social adjustment, quality of life and coping strategies*

Author

Meyer, Mylène, Montel, Sébastien, Colnat-Coulbois, Sophie, Lerond, Jérôme, Potheegadoo, Jevita, Vidailhet, Pierre, Gospodaru , Nicolaie, Vespignani, Hervé, Barroche, Gérard, Spitz, Elisabeth, Schwan, Raymund, UL, APEMAC, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurochirurgie [CHRU Nancy], Centre Psychothérapique de Nancy (CPN), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Université de Lorraine (UL), Centre d'Addictovigilance de Nancy [CHRU Nancy] (CEIP-A Nancy), and Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
coping, reviews, subthalamic nucleus, quality of life, social adjustment, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Parkinson's disease, neurodegenerative diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, neural regeneration, deep brain stimulation
Abstract

International audience; Subthalamic nucleus deep brain stimulation has become a standard neurosurgical therapy for advanced Parkinson's disease. Subthalamic nucleus deep brain stimulation can dramatically improve the motor symptoms of carefully selected patients with this disease. Surprisingly, some specific dimensions of quality of life, "psychological" aspects and social adjustment do not always improve, and they could sometimes be even worse. Patients and their families should fully understand that subthalamic nucleus deep brain stimulation can alter the motor status and time is needed to readapt to their new postoperative state and lifestyles. This paper reviews the literatures regarding effects of bilateral subthalamic nucleus deep brain stimulation on social adjustment, quality of life and coping strategies in patients with Parkinson's disease. The findings may help to understand the psychosocial maladjustment and poor improvement in quality of life in some Parkinson's disease patients.

Published
2013

23. Buprénorphine haut dosage et benzodiazépines, une association à risque : Réalité des coprescriptions en médecine de ville

Author

Di Patrizio, Paolo, Houille, Sophie, Schwan, Raymund, Boivin, Jean-Marc, Di Patrizio, Paolo, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), and Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

24. [Buprenorphin and benzodiazepines, an association with high risk. Reality of co-prescriptions by the general practitioners]

Author

Di Patrizio, Paolo, Houille, Sophie, Schwan, Raymund, Boivin, Jean-Marc, Di Patrizio, Paolo, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), and Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

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