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Francesca Simionato,1 Lorenzo Calvetti,1 Marco Cosci,2 Silvia Scarparo,3 Giuseppe Aprile1 1Department of Oncology, San Bortolo General Hospital, Vicenza, Italy; 2Department of Surgery, San Bortolo General Hospital, Vicenza, Italy; 3Pneumology Unit, San Bortolo General Hospital, Vicenza, ItalyCorrespondence: Francesca Simionato Tel +39444753608Email francesca.simionato@aulss8.veneto.itAbstract: Complex EGFR mutations are rare in non-small cell lung cancer (NSCLC). Limited clinical evidence is available on the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with NSCLC harbouring these uncommon EGFR mutations. Here, we reported the case of a complete metabolic response in a patient with advanced NSCLC carrying the uncommon EGFR G719A/V769M complex mutation treated with the first-line osimertinib.Keywords: non-small cell lung cancer, EGFR complex mutations, osimertinib

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