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Additional file 1: Supplemental Table 1. Odds ratios of maternal pre-pregnancy body mass index in the complete dataset (n = 84,366).

Supplemental material, sj-docx-1-cpc-10.1177_10556656221128425 for Null Association Between Isolated Orofacial Clefts and Sleep Duration: A Cohort Study From the Japan Environment and Children's Study by Yukihiro Sato, Eiji Yoshioka and Yasuaki Saijo, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi, in The Cleft Palate-Craniofacial Journal

Additional file 4: Supplemental Table 4. Crude and adjusted ORs of maternal education, psychological distress, and household income with 2-year outcomes.

Additional file 6: Supplemental Table 6. Adjusted ORs of maternal education and psychological distress (2-y questionnaire outcome added).

Additional file 2: Supplemental Table 2. Relationships between the variables and infant congenital heart defect.

Additional file 1: Supplemental Table 1. Education, K6 score, household income of the 2-year questionnaire respondents (N=80,468). *Chi-square test.

Additional file 7: Supplemental Table 7. Adjusted ORs of maternal education and psychological distress (only 2-y questionnaire outcome positive excluded).

Additional file 5: Supplemental Table 5. Crude and adjusted ORs of maternal education, psychological distress, and household income without 2-y outcomes.

Additional file 3: Supplemental Table 3. Crude and adjusted ORs of combined maternal education and psychological distress.

Supplemental_material for Trajectories of the Psychological Status of Mothers of Infants With Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children’s Study by Yukihiro Sato, Eiji Yoshioka, Yasuaki Saijo, Toshinobu Miyamoto, Kazuo Sengoku, Hiroshi Azuma, Yusuke Tanahashi, Yoshiya Ito, Sumitaka Kobayashi, Machiko Minatoya, Yu Ait Bamai, Keiko Yamazaki, Sachiko Ito, Chihiro Miyashita, Atsuko Araki, Reiko Kishi and Japan Environment and Children’s Study (JECS) Group in The Cleft Palate-Craniofacial Journal

In this paper, development of a hybrid structure with steel hybrid beam and reinforced concrete column (FRASH method) is carried out. The steel hybrid beam is a steel beam with the beam ends being reinforced concrete. The FRASH method reduces the usage of steel, which enables the reduction of the skeleton cost. And with the hybrid beam ends being reinforced concrete, rigidity of the beam increases resulting in a reduced floor vibration and improved habitability of the building.The outline of FRASH method, structural performance of hybrid beams in a beam-column sub- assemblage and construction example of FRASH method are discussed in this paper.

Yusuke Arai,1 Yukihiro Sato,1 Atsushi Yoshida,1 Hidetoshi Kawashima,1 Toshikatsu Kaburaki,2 Harumi Gomi3 1Department of Ophthalmology, JichiMedical University, Tochigi, Japan; 2Department of Ophthalmology, TheUniversity of Tokyo, Graduate School of Medicine, Tokyo, Japan; 3Center for Clinical Infectious Diseases, Jichi Medical University, Tochigi, Japan Purpose: Candida albicans subretinal abscess is extremely rare. To our knowledge, only one unilateral case has been reported. Herein, we report one bilateral case. Mixed bacterial infection was also suspected based on broad-range real-time polymerase chain reaction.Methods: A 64-year-old man being treated with oral corticosteroids for interstitial pneumonia visited us for visual loss in the left eye. Best corrected visual acuity (BCVA) was 20/20 in the right eye and 8/200 in the left eye. Funduscopy revealed round yellowish-white subretinal lesions with retinal hemorrhage in both eyes.Results: Broad-range polymerase chain reaction of the vitreous fluid from the left eye showed a high copy count of bacterial 16s ribosome RNA. Despite large doses of antibiotics, the abscess expanded and vision decreased to light perception in the left eye. Exenteration of the left eye was performed followed by microscopic examination showing Gram-negative bacilli, and C. albicans was also cultured. Antibiotics and the maximum doses of antifungal drugs were administered. However, the abscess in the right eye expanded, and BCVA decreased to 2/200. Vitrectomy and silicone oil tamponade were performed. Vitreous fluid culture revealed C. albicans. At 16 months follow-up, BCVA was stable at 4/200 with healing of the subretinal abscess under silicone oil.Conclusion: Since C. albicans subretinal abscess is extremely rare and there was a concurrent mixed bacterial infection, diagnostic procedures in our bilateral case were more complicated than usual. C. albicans infection should be included in the differential diagnosis of subretinal abscesses. Keywords: Candida albicans, subretinal abscess, mixed infection

Shinji Makino, Yuriko Ohkawara, Yukihiro SatoDepartment of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, JapanAbstract: A 77-year-old man presented with an inferior hemivisual field defect in the left eye. Funduscopy revealed well demarcated retinal edema of the superior quadrant resembling hemicentral retinal artery occlusion. Further, the upper and inferior retinal arteries emerged separately from the optic disc. Fluorescein angiography demonstrated a marked filling delay of the upper retinal artery. We repeated fluorescein angiography, which showed that the involved upper retinal artery was a cilioretinal artery having an earlier dye appearance than the lower retinal artery. We suggest that when cases of hemicentral retinal artery occlusion are encountered, vascular architecture at the optic disc should be evaluated carefully.Keywords: cilioretinal artery occlusion, hemicentral retinal artery occlusion, fluorescein fundus angiography

To our knowledge, there are no reports of Aeromonas hydrophila infection after a scleral buckling procedure. Also, migration of a silicone explant element through the rectus muscles is extremely rare. Herein, we describe a case experiencing extrusion of a solid silicone tire migrating through the superior rectus muscle with Aeromonas hydrophila infection following a scleral buckling procedure. A 42-year-old man was referred to our hospital complaining of ocular pain and purulent discharge in his left eye which has persisted for several months. He had a history of bilateral rhegmatogenous retinal detachment which had been treated with scleral buckling. The left eye showed extrusion of the solid silicone buckle which had migrated through the superior rectus muscle and an infection in the upper quadrant of the sclera. The buckle was removed, and the patient was treated with antibiotics. After the removal of the buckle, the symptoms showed rapid amelioration and there was no recurrence of retinal detachment. Aeromonas hydrophila was isolated from the discharge and the removed explant. He used well water in daily life. In this case, the Aeromonas hydrophila infection of the extruded buckle might have originated from contaminated well water.

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