Search

Your search keyword '"Sarcon, A"' showing total 93 results
Start Over Author "Sarcon, A" Database OpenAIRE
93 results on '"Sarcon, A"'

4. Isolated Left-Sided Accessory Pathway Potential

Author

Satoshi Higuchi, Damián Sánchez-Quintana, Annahita Sarcon, Eduardo Back Sternick, Melvin M. Scheinman, Robert H. Anderson, and Henry H. Hsia

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Supraventricular tachycardia, Accessory pathway, medicine.disease, business, Left sided
Published
2021
Full Text
View/download PDF

5. Atrial pacing above the lower rate limit: What is the cause?

Author

Amin Al-Ahmad, Domenico G. Della Rocca, Carola Gianni, and Anna Sarcon

Subjects
medicine.medical_specialty, Atrial pacing, business.industry, Cardiac Pacing, Artificial, Ventricular tachycardia, medicine.disease, Electrocardiography, Physiology (medical), Internal medicine, Cardiology, Humans, Medicine, Heart Atria, Cardiology and Cardiovascular Medicine, business
Published
2021
Full Text
View/download PDF

6. The Benefits of Local Anesthesia Used in Mastectomy Without Reconstruction

Author

Aida K Sarcon, Wenxia Zhang, Amy C Degnim, Rebecca L Johnson, William S. Harmsen, Amy E Glasgow, and James W Jakub

Subjects
General Medicine
Abstract

Background The opioid epidemic has driven renewed interest in local anesthesia to reduce postoperative opioid use. Our objective was to determine if local anesthesia decreased hospital pain scores, oral morphine equivalents (OME), length of stay (LOS), and nausea/vomiting. Methods Single institution retrospective study of females who underwent mastectomy without reconstruction. Results Overall, 712 patients were included; 63 (8.8%) received bupivacaine (B), 512 (72%) liposomal bupivacaine (LB), and 137 (19%) no local. 95% were discharged on POD1. Liposomal bupivacaine use increased from 2014 to 2019. Additional factors associated with use of local regimen were surgeon and extent of axillary surgery. Fewer patients used postop opioids during their hospital stay if any local was used compared to none (76 vs 88%; 0.003). Compared to none, local had shorter mean PACU LOS (95 vs 87 min; P = .02), lower mean intraoperative-OME (96 vs 106; P < .001), and lower mean postoperative OME/hr (1.4 vs 1.8 P = .001). Multivariable analysis (MVA) showed lower OME/hr with LB compared to B and none ( P = .002); this translates to 22 mg and 30 mg of oxycodone in a 24-hr period, respectively. MVA showed lower POD1 pain scores with LB relative to none ( P = .049). Local did not impact nausea/emesis. Conclusion Local anesthesia was superior to no local in several measures. However, a consistent benefit of a specific local anesthetic agent was not demonstrated (LB vs B). A prospective study is warranted to determine the optimal local regimen for this cohort and further inform clinical relevance.

Published
2022

7. A Tribute to Our Ultimate Teachers: Our Patients

Author

Anna Sarcon

Subjects
mitral valve, medicine.medical_specialty, business.industry, General surgery, Voices in Cardiology, Tribute, electrophysiology, beta-blockers, Viewpoint, medicine.anatomical_structure, Mitral valve, medicine, Cardiology and Cardiovascular Medicine, business
Published
2021
Full Text
View/download PDF

8. Prediction of short‐ and long‐term mortality in takotsubo syndrome: the InterTAK Prognostic Score

Author

Thomas Münzel, Yoshio Kobayashi, Wolfgang Koenig, Hugo A. Katus, Paul Bridgman, Christina Chan, Ioana Sorici-Barb, Eduardo Bossone, Gregor Poglajen, Abhiram Prasad, Fabrizio D'Ascenzo, Jelena R. Ghadri, Monika Budnik, Konrad A. Szawan, Fausto J. Pinto, David E. Winchester, Guido Michels, Carlo Di Mario, Thomas Fischer, Matteo Bianco, Jerold S. Shinbane, Burkert Pieske, Alessandro Candreva, Rodolfo Citro, P. Christian Schulze, Annahita Sarcon, Kan Liu, Christian Ukena, Christoph Kaiser, Martin Borggrefe, Florim Cuculi, Stefan Osswald, Behrouz Kherad, Heribert Schunkert, Jeroen J. Bax, Maike Knorr, Ken Kato, Petr Widimský, Alexandra Shilova, Frank Ruschitzka, Martin Kozel, Victoria L. Cammann, Roman Pfister, Olivier Lairez, Michael Neuhaus, Alessandro Cuneo, Wolfgang Rottbauer, Ibrahim Akin, Lucas Jörg, Christian Hauck, L. Christian Napp, Holger Thiele, Manfred Wischnewsky, K.E. Juhani Airaksinen, Hans Rickli, Tuija Vasankari, Carla Paolini, Lars S. Maier, Philippe Meyer, Adrian P. Banning, Richard Kobza, Beatrice Bacchi, Miłosz Jaguszewski, Rafal Dworakowski, Michael Böhm, Claudio Bilato, Mahir Karakas, Philip MacCarthy, Mikhail Gilyarov, Charanjit S. Rihal, Alexander Pott, Claudius Jacobshagen, Clément Delmas, Jose David Arroja, Ibrahim El-Battrawy, Filippo Crea, Carsten Tschöpe, Pedro Carrilho-Ferreira, Ekaterina Gilyarova, Jennifer Franke, Daniel Beug, Ruediger C. Braun-Dullaeus, John D. Horowitz, Thanh H Nguyen, Sebastiano Gili, Christof Burgdorf, Jan Galuszka, Leonarda Galiuto, Grzegorz Opolski, Susanne Heiner, Johann Bauersachs, Christian Templin, Petr Tousek, Michel Noutsias, Lawrence Rajan, Stephan B. Felix, Wolfgang Dichtl, Thomas F. Lüscher, Gerd Hasenfuß, Wischnewsky, Mb, Candreva, A, Bacchi, B, Cammann, Vl, Kato, K, Szawan, Ka, Gili, S, D'Ascenzo, F, Dichtl, W, Citro, R, Bossone, E, Neuhaus, M, Franke, J, Sorici-Barb, I, Jaguszewski, M, Noutsias, M, Knorr, M, Heiner, S, Burgdorf, C, Kherad, B, Tschope, C, Sarcon, A, Shinbane, J, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Koenig, W, Pott, A, Meyer, P, Arroja, Jd, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Napp, Lc, Budnik, M, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Chan, C, Bridgman, P, Beug, D, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Gilyarova, E, Shilova, A, Gilyarov, M, Kozel, M, Tousek, P, Winchester, De, Galuszka, J, Ukena, C, Poglajen, G, Carrilho-Ferreira, P, Hauck, C, Paolini, C, Bilato, C, Prasad, A, Rihal, C, Liu, K, Schulze, Pc, Bianco, M, Jorg, L, Rickli, H, Nguyen, Th, Kobayashi, Y, Bohm, M, Maier, L, Pinto, Fj, Widimsky, P, Borggrefe, M, Felix, Sb, Opolski, G, Braun-Dullaeus, Rc, Rottbauer, W, Hasenfuss, G, Pieske, Bm, Schunkert, H, Thiele, H, Bauersachs, J, Katus, Ha, Horowitz, J, Di Mario, C, Munzel, T, Crea, F, Bax, Jj, Luscher, Tf, Ruschitzka, F, Ghadri, Jr, Templin, C, and Repositório da Universidade de Lisboa

Subjects
Male, Research design, medicine.medical_specialty, MEDLINE, 030204 cardiovascular system & hematology, Prognostic score, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, 030212 general & internal medicine, Survival analysis, Aged, Aged, 80 and over, Takotsubo syndrome, business.industry, Stroke Volume, Stroke volume, Middle Aged, Prognosis, medicine.disease, Survival Analysis, 3. Good health, Research Design, Heart failure, Cardiology, Female, Long term mortality, Cardiology and Cardiovascular Medicine, business
Abstract

© 2019 The Authors European Journal of Heart Failure © 2019 European Society of Cardiology, Recent evidence suggests comparable in‐hospital and long‐term outcomes between takotsubo syndrome (TTS) and acute coronary syndrome. Medical scoring systems are practical tools for decision making and prognostic assessment. However, TTS‐specific scoring systems for risk stratification have not yet been established. Recently, classification based on triggering conditions proved useful in predicting adverse outcomes in TTS (InterTAK Classification).1 Since clinical parameters other than triggering conditions can be associated with adverse outcomes in TTS, such as systolic blood pressure and heart rate, the present study aimed to establish a scoring system combining triggering factors with other important but easily‐ obtainable clinical parameters of daily clinical practice., C.T. has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation. L.S.M. was supported by EU HORIZON 2020 (SILICOFCM ID777204). The InterTAK Registry is supported by the Biss Davies Charitable Trust.

Published
2019
Full Text
View/download PDF

9. Fractionated Epicardial Electrograms

Author

Charles Antzelevitch, Arthur A.M. Wilde, Bence Patocskai, José M. Di Diego, Anna Sarcon, Henry H. Hsia, Melvin M. Scheinman, and Pieter G. Postema

Subjects
medicine.medical_specialty, Mechanism (biology), business.industry, Internal medicine, Brugada pattern, Ventricular fibrillation, medicine, Cardiology, Ventricular tachycardia, medicine.disease, business, Brugada syndrome
Published
2021
Full Text
View/download PDF

10. Epicardial Ablation Complications

Author

David Burkhardt, Rodney Horton, Domenico G. Della Rocca, Giovanni B. Forleo, Anu Sahore, Andrea Natale, Xiao Dong Zhang, Chintan Trivedi, Carlo Lavalle, Nicola Tarantino, Uğur Canpolat, Mohamed Bassiouny, Kudret Aytemir, Joseph G. Gallinghouse, Alisara Anannab, Luigi Di Biase, Hüseyin Ayhan, Jorge Romero, Michela Faggioni, Amin Al-Ahmad, Sanghamitra Mohanty, and Annahita Sarcon

Subjects
Epicardial Mapping, medicine.medical_specialty, Percutaneous, Defibrillation, medicine.medical_treatment, Epicardial ablation, 030204 cardiovascular system & hematology, Ventricular tachycardia, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Atrial tachycardia, business.industry, Cardiac arrhythmia, Arrhythmias, Cardiac, medicine.disease, Ablation, Catheter Ablation, cardiovascular system, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Heart failure with preserved ejection fraction
Abstract

The percutaneous epicardial approach has become an adjunctive tool for electrophysiologists to treat disparate cardiac arrhythmias, including accessory pathways, atrial tachycardia, and particularly ventricular tachycardia. This novel technique prompted a strong impulse to perform epicardial access as an alternative strategy for pacing and defibrillation, left atrial appendage exclusion, heart failure with preserved ejection fraction, and genetically engineered tissue delivery. However, because of the incremental risk of major complications compared with stand-alone endocardial ablation, it is still practiced in a limited number of highly experienced centers across the world.

Published
2020
Full Text
View/download PDF

11. Acute dilated cardiomyopathy in the setting of catastrophic antiphospholipid syndrome and thrombotic microangiopathy: A case series and review

Author

Luanda Grazette, Arjun Mehta, Melody Hermel, Erika Jones, Saif Azam, Ilene C. Weitz, Annahita Sarcon, David J. Hermel, Howard A. Liebman, and Jerold S. Shinbane

Subjects
medicine.medical_specialty, Thrombotic microangiopathy, business.industry, Internal medicine, Atypical hemolytic uremic syndrome, medicine, Cardiology, Cardiomyopathy, Dilated cardiomyopathy, medicine.disease, Catastrophic antiphospholipid syndrome, business, Complement (complexity)
Abstract

Catastrophic antiphospholipid antibody syndrome (CAPS) is a rare form of antiphospholipid syndrome, an autoimmune condition characterized by vascular thromboses, pregnancy loss, and antiphospholipid (aPL) antibodies. Diagnosis of CAPS relies on thrombosis of at least three different organs systems over 1 week, histopathological evidence of small vessel occlusion, and high aPL antibody titers. In a subset of precipitating circumstances, activation or disruption of endothelial cells in the microvasculature may occur along with cardiomyopathy. We present two cases of CAPS-associated dilated cardiomyopathy at our institution, focusing on disease management, pathophysiology, and treatment. These patients were of Southeastern Asian descent, raising the possibility of genetic polymorphisms contributing to the development of cardiomyopathy. Both met CAPS criteria and both demonstrated clinicopathologic thrombotic microangiopathy (TMA) and complement activation and developed severe dilated cardiomyopathy with shock. Complement activation plays an important role in the development of CAPS and may be important in the pathogenesis of CAPS-associated cardiomyopathy. Clinical suspicion for TMA as a pathophysiologic mechanism of unexplained heart failure in CAPS is important and increased awareness of cardiac side effects is necessary so that early treatment can be initiated to halt further cardiac and systemic complications.

Published
2020
Full Text
View/download PDF

13. Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndrome : new insights from the International Takotsubo Registry

Author

Wolfgang Koenig, John D. Horowitz, Hugo A. Katus, Paul Bridgman, Abhiram Prasad, Carlo Di Mario, Alessandro Cuneo, Johann Bauersachs, Jeroen J. Bax, Mathias Wolfrum, Carsten Tschöpe, Masanori Sano, Vanya Petkova, Lucas Jörg, Fausto J. Pinto, Petr Widimský, Masayuki Takahara, Rodolfo Citro, Iwao Ishibashi, Frank Ruschitzka, Thomas Münzel, Carmine Vecchione, Wolfgang Dichtl, Jan Galuszka, Kan Liu, Leonarda Galiuto, Grzegorz Opolski, Jozef Micek, Susanne Heiner, Florim Cuculi, Gerd Hasenfuß, Jerold S. Shinbane, Maike Knorr, Sebastiano Gili, Filippo Crea, Michael Würdinger, Alexandra Shilova, Malcolm Kohler, Lawrence Rajan, Christian F Clarenbach, Rena A. Levinson, Mikhail Gilyarov, Alexander Pott, Roman Pfister, Ekaterina Gilyarova, Claudius Jacobshagen, Adrian P. Banning, Michael Neuhaus, Jennifer Franke, Christian Templin, Christof Burgdorf, Daniel Beug, K.E. Juhani Airaksinen, Victoria L. Cammann, Thanh H Nguyen, Rafael Sumalinog, Monika Budnik, Wolfgang Rottbauer, Yoshio Kobayashi, Petr Tousek, Stephan B. Felix, Marco Roffi, Michael Böhm, Konrad A. Szawan, Toshiharu Himi, Ibrahim Akin, Christina Chan, Thomas F. Lüscher, Rafal Dworakowski, Annahita Sarcon, Ibrahim El-Battrawy, Miłosz Jaguszewski, Alexandru Patrascu, Eduardo Bossone, David E. Winchester, Michel Noutsias, Guido Michels, Gregor Poglajen, Christian Hauck, Fabrizio D'Ascenzo, Burkert Pieske, Christian Ukena, Thomas Fischer, Matteo Bianco, Lars S. Maier, Christoph Kaiser, Philippe Meyer, P. Christian Schulze, Behrouz Kherad, Gonçalo Pestana, Claudio Bilato, Ken Kato, Martin Kozel, Charanjit S. Rihal, Clément Delmas, Stefan Osswald, Olivier Lairez, Jelena R. Ghadri, Martin Borggrefe, Philip MacCarthy, Heribert Schunkert, Manfred Wischnewsky, Sara Dreiding, Hans Rickli, Tuija Vasankari, L. Christian Napp, Holger Thiele, Richard Kobza, Carla Paolini, Benjamin Meder, Mahir Karakas, Pedro Carrilho-Ferreira, Ruediger C. Braun-Dullaeus, Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Sano, M., Ishibashi, I., Takahara, M., Himi, T., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, F., Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Acute respiratory insufficiency, acute respiratory insufficiency, Shock, Cardiogenic, 030204 cardiovascular system & hematology, Broken heart syndrome, chronic obstructive pulmonary disease, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Original Research Articles, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, takotsubo syndrome, Registries, Original Research Article, 030212 general & internal medicine, Survival analysis, Outcome, Takotsubo syndrome, intertak registry, business.industry, InterTAK Registry, Incidence (epidemiology), Cardiogenic shock, Chronic obstructive pulmonary disease, Hazard ratio, broken heart syndrome, Shock, Cardiogenic, Prognosis, medicine.disease, Survival Analysis, outcome, Confidence interval, 3. Good health, RC666-701, Heart failure, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Cardiology and Cardiovascular Medicine, business
Abstract

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License., Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002). Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome., C. T. has been supported by the H.H. Sheikh Khalifa binHamad Al-Thani Research Programme and the Swiss HeartFoundation. The InterTAK Registry is supported by the BissDavies Charitable Trust. L. S. M. has been supported by EUHORIZON 2020(SILICOFCM ID777204)

Published
2021

14. A Prospective Randomized Investigation Comparing Functional Outcomes of Syndesmotic Suture-Button Fixation to Screws

Author

James P. Stannard, Aida K. Sarcon, Vicki Jones, Tyler Allen, David N. Garras, Todd Oliver, Trevor J. Shelton, Kyle Fiala, Patrick Barousse, Medardo Richard Maroto, Eric Giza, Gregory J. Della Rocca, David A. Volgas, Michelle Vogt, Jonathan Fech, Johnny Lin, Christopher Kreulen, Emma Briggs, James A. Ronan, Benjamin Summerhays, Brett D. Crist, Ashoke Sathy, and Wade Faerber

Subjects
Orthodontics, Syndesmosis, Fixation (surgical), medicine.anatomical_structure, business.industry, Suture button, medicine, business, Screw fixation
Published
2020
Full Text
View/download PDF

16. Three-dimensional mapping, recording and ablation in simulated and induced ventricular tachyarrhythmias during mechanical circulatory support using the percutaneous heart pump

Author

Arash, Aryana, Anna, Sarcon, Mark R, Bowers, Padraig Gearoid, O'Neill, Maheer, Gandhavadi, and André, d'Avila

Abstract

Due to their internal rotating magnets, conventional impeller-driven percutaneous ventricular assist devices (PVADs) yield high-frequency electrogram artifact and electromagnetic interference (EMI) when used with magnetic-based 3D electroanatomic mapping systems. The new percutaneous heart pump (PHP; Abbott, Chicago, IL) is a 14-French, 5-L/min, impeller axial-flow PVAD with a novel design that utilizes an external motor.We evaluated the feasibility of 3D mapping and radiofrequency ablation (RFA) in vivo during PHP mechanical circulatory support (MCS) in simulated ventricular tachycardia (pacing at 300 ms) and ventricular flutter (VFL, pacing at 200 ms) and also during ventricular fibrillation (VF) in a porcine model. Anterograde (right ventricular), transseptal, retrograde, and epicardial right and left ventricular 3D mapping (EnSite/CARTO) and RFA were performed in 6 swine using high-density mapping and force-sensing RFA catheters (TactiCath/ThermoCool). Surface and intracardiac electrograms and 3D maps were analyzed for noise/interference with and without MCS using PHP in sinus rhythm and simulated VT/VFL and VF.Mapping and RFA proved feasible in the presence of MCS using PHP. The mean arterial pressure in sinus rhythm was 55 ± 2 mmHg (baseline) and 84 ± 4 mmHg during MCS with PHP and well-maintained during simulated VT (73 ± 8 mmHg) and VFL (65 ± 2 mmHg) and even in VF (65 ± 5 mmHg). No electrogram noise/artifact, EMI, or 3D map distortions were observed during mapping/RFA with either of two mapping systems.Endocardial and epicardial 3D mapping and RFA in the presence of PHP are feasible and offer significant MCS during simulated VT/VFL and VF. Furthermore, PHP yielded no electrogram noise/artifact, EMI, or 3D mapping distortions in conjunction with magnetic-based 3D mapping systems.

Published
2021

17. Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry

Author

El-Battrawy, Ibrahim, Cammann, Victoria L, Kato, Ken, Szawan, Konrad A, Di Vece, Davide, Rossi, Aurelio, Wischnewsky, Manfred, Hermes-Laufer, Julia, Gili, Sebastiano, Citro, Rodolfo, Bossone, Eduardo, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Milosz, Noutsias, Michel, Knorr, Maike, Heiner, Susanne, D'Ascenzo, Fabrizio, Dichtl, Wolfgang, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, et al, and University of Zurich

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2021

18. Hashtags in Medicine

Author

Anna Sarcon and DO Bing Liem

Subjects
medicine.medical_specialty, Viewpoint, business.industry, Family medicine, RC666-701, medicine, MEDLINE, Diseases of the circulatory (Cardiovascular) system, Voices in Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Central Illustration

Published
2021

19. Ethnic comparison in takotsubo syndrome

Author

Stefan Osswald, Yasuhiro Tomita, Yoichi Imori, Christian Templin, Jerold S. Shinbane, Petr Widimský, Wolfgang Dichtl, Maike Knorr, Petr Tousek, Olivier Lairez, Iwao Ishibashi, Tetsuo Yamaguchi, Frank Ruschitzka, Johann Bauersachs, Sebastiano Gili, Toshiaki Isogai, Jelena R. Ghadri, Roman Pfister, Florim Cuculi, Thomas Münzel, Victoria L. Cammann, Hugo A. Katus, Pedro Carrilho-Ferreira, Hitoshi Takano, Paul Bridgman, Wolfgang Koenig, Annahita Sarcon, Tsutomu Murakami, Christof Burgdorf, Wolfgang Rottbauer, Ibrahim Akin, Rodolfo Citro, John D. Horowitz, Philip MacCarthy, Reiko Shiomura, Michel Noutsias, Stephan B. Felix, Fausto J. Pinto, Adrian P. Banning, Yoshio Kobayashi, Thomas F. Lüscher, Martin Borggrefe, Ioana Sorici-Barb, Monika Budnik, Lucas Jörg, Thomas Jansen, Abhiram Prasad, Carlo Di Mario, Alexander Pott, Rafal Dworakowski, Kan Liu, Akihisa Kimura, Lawrence Rajan, Konrad A. Szawan, Christian Hauck, Vanya Petkova, Shingo Mizuno, Christina Chan, Rena A. Levinson, Claudius Jacobshagen, Lars S. Maier, Richard Kobza, Masaki Wakita, Jan Galuszka, Fabrizio D'Ascenzo, Gerd Hasenfuß, Shunichi Nakamura, Philippe Meyer, Mikhail Gilyarov, Ruediger C. Braun-Dullaeus, Michael Böhm, Alexandra Shilova, Jeroen J. Bax, Davide Di Vece, K.E. Juhani Airaksinen, David Niederseer, Alessandro Cuneo, Jennifer Franke, Michael Neuhaus, Heribert Schunkert, Samir M. Said, Jose David Arroja, Hiroki Mochizuki, Mahir Karakas, Maximilian Schönberger, David E. Winchester, Daniel Beug, Thomas Fischer, Matteo Bianco, Carsten Tschöpe, Filippo Crea, Michael Würdinger, Guido Michels, Burkhardt Seifert, Ekaterina Gilyarova, Leonarda Galiuto, Wataru Shimizu, Burkert Pieske, Grzegorz Opolski, L. Christian Napp, Holger Thiele, Charanjit S. Rihal, Christian Ukena, Susanne Heiner, Christoph Kaiser, Noriko Suzuki, Clément Delmas, Shigeru Saito, Manfred Wischnewsky, Klaus Empen, Sara Dreiding, Hans Rickli, Claudio Bilato, Tuija Vasankari, Toshiharu Himi, Ibrahim El-Battrawy, Behrouz Kherad, Yuji Ikari, Ken Kato, Martin Kozel, Eduardo Bossone, Gregor Poglajen, Miłosz Jaguszewski, Carla Paolini, and Repositório da Universidade de Lisboa

Subjects
Male, medicine.medical_specialty, Prognostic factor, Race, Ethnic group, Shock, Cardiogenic, Disease, 030204 cardiovascular system & hematology, Broken heart syndrome, White People, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Takotsubo Cardiomyopathy, Internal medicine, medicine, Prevalence, Ethnicity, Humans, 030212 general & internal medicine, Hospital Mortality, Registries, Aged, Takotsubo syndrome, business.industry, Cardiogenic shock, General Medicine, Health Status Disparities, Middle Aged, medicine.disease, ddc, Europe, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/., Background: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers., Open Access funding provided by Universität Zürich. CT has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation. L.S.M. has been supported by EU HORIZON 2020 (SILICOFCM ID777204). J.R.G has received a grant “Filling the gap” from the University of Zurich. The InterTAK Registry is supported by The Biss Davies Charitable Trust.

Published
2021

20. Pleomorphic wide complex tachycardia

Author

Anna Sarcon, Eunjeong Kim, David G. Rosenthal, and Melvin M. Scheinman

Subjects
Aged, 80 and over, Male, Electrocardiography, Adenosine, Physiology (medical), Catheter Ablation, Humans, Tachycardia, Atrioventricular Nodal Reentry, Cardiology and Cardiovascular Medicine, Atrioventricular Block, Electrophysiologic Techniques, Cardiac, Anti-Arrhythmia Agents
Published
2021

22. Long-Term Prognosis of Patients With Takotsubo Syndrome

Author

John D. Horowitz, Thomas Münzel, David E. Winchester, Guido Michels, Katharina J. Ding, Wolfgang Koenig, Jeroen J. Bax, Burkert Pieske, Mahir Karakas, Christian Ukena, K.E. Juhani Airaksinen, Christoph Kaiser, Sebastiano Gili, Stephan B. Felix, Rafal Dworakowski, Christian Templin, Claudius Jacobshagen, Abhiram Prasad, Fabrizio D'Ascenzo, Lawrence Rajan, Martin Borggrefe, Rena A. Levinson, Christof Burgdorf, Florim Cuculi, Petr Tousek, Thomas F. Lüscher, Alexandra Shilova, Mikhail Gilyarov, Victoria L. Cammann, Roman Pfister, Frank Ruschitzka, Alessandro Candreva, Filippo Crea, Davide Di Vece, Wolfgang Rottbauer, Ruediger C. Braun-Dullaeus, Heribert Schunkert, Carsten Tschöpe, Stefan Osswald, Rodolfo Citro, Burkhardt Seifert, Annahita Sarcon, Ibrahim Akin, Gerd Hasenfuß, Leonarda Galiuto, L. Christian Napp, Holger Thiele, Ekaterina Gilyarova, Grzegorz Opolski, Susanne Heiner, Michel Noutsias, Johann Bauersachs, Miłosz Jaguszewski, Alessandro Cuneo, Hugo A. Katus, Olivier Lairez, Ibrahim El-Battrawy, Wolfgang Dichtl, Jozef Micek, Philip MacCarthy, Rahel Bianchi, Maike Knorr, Ken Kato, Adrian P. Banning, Jelena-R. Ghadri, Martin Kozel, Michael Böhm, Konrad A. Szawan, Jennifer Franke, Manfred Wischnewsky, Klaus Empen, Tuija Vasankari, Eduardo Bossone, Richard Kobza, Beatrice Bacchi, Susanne A. Schlossbauer, Petr Widimský, Stjepan Jurisic, Samir M. Said, Thomas Fischer, Clément Delmas, Ghadri, Jr, Kato, K, Cammann, Vl, Gili, S, Jurisic, S, Di Vece, D, Candreva, A, Ding, Kj, Micek, J, Szawan, Ka, Bacchi, B, Bianchi, R, Levinson, Ra, Wischnewsky, M, Seifert, B, Schlossbauer, Sa, Citro, R, Bossone, E, Munzel, T, Knorr, M, Heiner, S, D'Ascenzo, F, Franke, J, Sarcon, A, Napp, Lc, Jaguszewski, M, Noutsias, M, Katus, Ha, Burgdorf, C, Schunkert, H, Thiele, H, Bauersachs, J, Tschope, C, Pieske, Bm, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Hasenfuss, G, Karakas, M, Koenig, W, Rottbauer, W, Said, Sm, Braun-Dullaeus, Rc, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Crea, F, Dichtl, W, Empen, K, Felix, Sb, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Borggrefe, M, Horowitz, J, Kozel, M, Tousek, P, Widimsky, P, Gilyarova, E, Shilova, A, Gilyarov, M, Winchester, De, Ukena, C, Bax, Jj, Prasad, A, Bohm, M, Luscher, Tf, Ruschitzka, F, and Templin, C

Subjects
Male, Acute coronary syndrome, medicine.medical_specialty, Time Factors, 030204 cardiovascular system & hematology, tako tsubo syndrome, acute coronary syndrome, broken heart syndrome, classification, outcome, stress factor, Broken heart syndrome, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, Registries, 030212 general & internal medicine, Mortality, Aged, Aged, 80 and over, Takotsubo syndrome, business.industry, Mortality rate, Electroencephalography, Emotional stress, Middle Aged, ta3121, Prognosis, Stress factor, medicine.disease, 3. Good health, Physical stress, Cardiology and Cardiovascular Medicine, Cohort, Female, Nervous System Diseases, business, Stress, Psychological, Follow-Up Studies
Abstract

Background Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive. Objectives This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers. Methods Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions. Results Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients. Conclusions Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (International Takotsubo Registry [InterTAK Registry]; NCT01947621)

Published
2018

23. Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry

Author

Christian Templin, Antonio H. Frangieh, John D. Horowitz, Rodolfo Citro, Johann Bauersachs, Petr Widimský, Philip MacCarthy, David E. Winchester, Andrea Saglietto, Alessandro Cuneo, Guido Michels, Ekaterina Gilyarova, Burkert Pieske, Christian Ukena, Frank Ruschitzka, Christoph Kaiser, Mauro Gasparini, Mario Iannaccone, Wolfgang Koenig, Eduardo Bossone, Gaetano M. De Ferrari, Miłosz Jaguszewski, Florim Cuculi, Jeroen J. Bax, Wolfgang-Michael Franz, Leonarda Galiuto, L. Christian Napp, Grzegorz Opolski, Holger Thiele, Susanne Heiner, Abhiram Prasad, Carlo Di Mario, Stephan B. Felix, Thomas Münzel, Margherita Annaratone, Roman Pfister, Thomas F. Lüscher, Adrian P. Banning, Ruediger C. Braun-Dullaeus, Konrad A. Szawan, K.E. Juhani Airaksinen, Mahir Karakas, Michael Böhm, Victoria L. Cammann, Gerd Hasenfuß, Wolfgang Rottbauer, Rena A. Levinson, Samir M. Said, Ibrahim Akin, Fabrizio D'Ascenzo, Lawrence Rajan, Maike Knorr, Thomas Fischer, Rafal Dworakowski, Mikhail Gilyarov, Maurizio Bertaina, Annahita Sarcon, Mauro Rinaldi, Ken Kato, Martin Kozel, Wolfgang Dichtl, Carsten Tschöpe, Hugo A. Katus, Filippo Crea, Clément Delmas, Jennifer Franke, Giuseppe Biondi-Zoccai, Claudius Jacobshagen, Ibrahim El-Battrawy, Alexandra Shilova, Sebastiano Gili, Davide Di Vece, Beatrice Boffini, Michael Neuhaus, Christof Burgdorf, Petr Tousek, Jelena R. Ghadri, Martin Borggrefe, Stefan Osswald, Olivier Lairez, Richard Kobza, Heribert Schunkert, Klaus Empen, Tuija Vasankari, Michel Noutsias, D'Ascenzo, F., Gili, S., Bertaina, M., Iannaccone, M., Cammann, V. L., Di Vece, D., Kato, K., Saglietto, A., Szawan, K. A., Frangieh, A. H., Boffini, B., Annaratone, M., Sarcon, A., Levinson, R. A., Franke, J., Napp, L. C., Jaguszewski, M., Noutsias, M., Munzel, T., Knorr, M., Heiner, S., Katus, H. A., Burgdorf, C., Schunkert, H., Thiele, H., Bauersachs, J., Tschope, C., Pieske, B. M., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Hasenfuss, G., Karakas, M., Koenig, W., Rottbauer, W., Said, S. M., Braun-Dullaeus, R. C., Banning, A., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Opolski, G., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Crea, F., Dichtl, W., Franz, W. M., Empen, K., Felix, S. B., Delmas, C., Lairez, O., El-Battrawy, I., Akin, I., Borggrefe, M., Horowitz, J. D., Kozel, M., Tousek, P., Widimsky, P., Gilyarova, E., Shilova, A., Gilyarov, M., Biondi-Zoccai, G., Winchester, D. E., Ukena, C., Neuhaus, M., Bax, J. J., Prasad, A., Di Mario, C., Bohm, M., Gasparini, M., Ruschitzka, F., Bossone, E., Citro, R., Rinaldi, M., De Ferrari, G. M., Luscher, T., Ghadri, J. R., and Templin, C.

Subjects
medicine.medical_specialty, Medical therapy, Acute heart failure, Aspirin, Outcome, Takotsubo syndrome, Myocardial Infarction, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Recurrence, Takotsubo Cardiomyopathy, law, Internal medicine, medicine, Humans, Registries, Myocardial infarction, Propensity Score, Stroke, Heart Failure, business.industry, Hazard ratio, medicine.disease, Confidence interval, 3. Good health, Treatment Outcome, Ischemic Attack, Transient, Heart failure, Propensity score matching, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Cardiology, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

Aims The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.

Published
2020

24. Intraventricular thrombus formation and embolism in Takotsubo syndrome insights from the international Takotsubo registry

Author

Alexandra Shilova, Davide Di Vece, Johann Bauersachs, Wolfgang Koenig, Michael Neuhaus, Rodolfo Citro, Jose David Arroja, Adrian P. Banning, Jennifer Franke, Charanjit S. Rihal, Abhiram Prasad, Carlo Di Mario, Michael Böhm, Carsten Tschöpe, Burkhardt Seifert, Filippo Crea, Christian Templin, David E. Winchester, Hugo A. Katus, Clément Delmas, Pedro Carrilho-Ferreira, Paul Bridgman, Petr Tousek, Guido Michels, Fausto J. Pinto, Sebastiano Gili, Jelena R. Ghadri, Petr Widimský, Burkert Pieske, Jeroen J. Bax, Christian Ukena, Christoph Kaiser, Wolfgang Dichtl, Christof Burgdorf, Philippe Meyer, Christina Chan, Gerd Hasenfuß, Philip MacCarthy, Mikhail Gilyarov, Leonarda Galiuto, Grzegorz Opolski, Susanne Heiner, Ruediger C. Braun-Dullaeus, Alexander Pott, Annahita Sarcon, Ekaterina Gilyarova, Michel Noutsias, Lawrence Rajan, Claudius Jacobshagen, Roman Pfister, Behrouz Kherad, John D. Horowitz, Martin Borggrefe, Mahir Karakas, Stefan Osswald, Victoria L. Cammann, Katharina J. Ding, Jan Galuszka, Wolfgang Rottbauer, Ibrahim El-Battrawy, Stephan B. Felix, Martin Kozel, Ibrahim Akin, Thomas F. Lüscher, Frank Ruschitzka, Thomas Fischer, Fabrizio D'Ascenzo, Rafal Dworakowski, Olivier Lairez, L. Christian Napp, Holger Thiele, Eduardo Bossone, Thomas Münzel, Claudio Bilato, Maike Knorr, K.E. Juhani Airaksinen, Florim Cuculi, Carla Paolini, Konrad A. Szawan, Richard Kobza, Alessandro Cuneo, Barbara E. Stähli, Heribert Schunkert, Miłosz Jaguszewski, Manfred Wischnewsky, Tuija Vasankari, Ding, Kj, Cammann, Vl, Szawan, Ka, Stähli, Be, Wischnewsky, M, Di Vece, D, Citro, R, Jaguszewski, M, Seifert, B, Sarcon, A, Knorr, M, Heiner, S, Gili, S, D'Ascenzo, F, Neuhaus, M, Napp, Lc, Franke, J, Noutsias, M, Burgdorf, C, Koenig, W, Kherad, B, Rajan L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Pott, A, Meyer, P, Arroja, Jd, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Paolini, C, Bilato, C, Carrilho-Ferreira, P, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Gilyarova, E, Shilova, A, Gilyarov, M, Kozel, M, Tousek, P, Widimský, P, Winchester, De, Galuszka, J, Ukena, C, Horowitz, Jd, Di Mario, C, Prasad A, Rihal, C, Pinto, Fj, Crea, F, Borggrefe, M, Braun-Dullaeus, Rc, Rottbauer, W, Bauersachs, J, Katus, Ha, Hasenfuß, G, Tschöpe, C, Pieske, Bm, Thiele, H, Schunkert, H, Böhm, M, Felix, Sb, Münzel, T, Bax, Jj, Lüscher, Tf, Ruschitzka, F, Ghadri, Jr, Bossone, E, and Templin, C.

Subjects
Male, Coronary angiography, Time Factors, Radionuclide ventriculography, 030204 cardiovascular system & hematology, Coronary Angiography, Electrocardiography, 0302 clinical medicine, Risk Factors, Registries, 030212 general & internal medicine, Framingham Risk Score, medicine.diagnostic_test, Incidence, Incidence (epidemiology), Magnetic Resonance Imaging, 3. Good health, Europe, Survival Rate, Cine, thrombus, cardiovascular system, Cardiology, outcome, Female, Cardiology and Cardiovascular Medicine, Takotsubo syndrome, medicine.medical_specialty, Heart Diseases, Heart Ventricles, Magnetic Resonance Imaging, Cine, risk score, Risk Assessment, embolism, 03 medical and health sciences, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, cardiovascular diseases, Thrombus, Radionuclide Ventriculography, Aged, business.industry, Australia, Thrombosis, medicine.disease, United States, Embolism, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, business, Follow-Up Studies
Abstract

Objective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0–38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×10 3 cells/μL emerged as independent predictors for thrombus formation or embolism. Conclusions: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01947621.

Published
2020

25. Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Alessandro Cuneo, Rodolfo Citro, Sebastiano Gili, Victoria L. Cammann, L. Christian Napp, Wolfgang Rottbauer, Heribert Schunkert, Alexandra Shilova, Roman Pfister, Holger Thiele, Ibrahim Akin, Annahita Sarcon, Christof Burgdorf, Wolfgang Dichtl, Wolfgang Koenig, Petr Widimský, Pedro Carrilho-Ferreira, Mikhail Gilyarov, Philip MacCarthy, Fabrizio D'Ascenzo, Jeroen J. Bax, Hugo A. Katus, Paul Bridgman, K.E. Juhani Airaksinen, Eduardo Bossone, Stefan Osswald, Yoshio Kobayashi, Jan Galuszka, Gregor Poglajen, John D. Horowitz, Thomas Fischer, Ruediger C. Braun-Dullaeus, Konrad A. Szawan, Abhiram Prasad, Carlo Di Mario, Fausto J. Pinto, Thomas Münzel, Jennifer Franke, Carla Paolini, Richard Kobza, Christina Chan, Daniel Beug, Olivier Lairez, Claudio Bilato, Mahir Karakas, Florim Cuculi, Gerd Hasenfuß, Lawrence Rajan, Tuija Vasankari, Philippe Meyer, David E. Winchester, Jelena R. Ghadri, Adrian P. Banning, Leonarda Galiuto, Guido Michels, Stjepan Jurisic, Michel Noutsias, Rafal Dworakowski, Grzegorz Opolski, Maike Knorr, Susanne Heiner, Behrouz Kherad, Christian Templin, Johann Bauersachs, Stephan B. Felix, Burkert Pieske, Frank Ruschitzka, Martin Borggrefe, Petr Tousek, Thomas F. Lüscher, Michael Böhm, Christian Ukena, Ken Kato, Christoph Kaiser, Martin Kozel, Filippo Crea, Ekaterina Gilyarova, Ibrahim El-Battrawy, Charanjit S. Rihal, Clément Delmas, Alexander Pott, Claudius Jacobshagen, Jose David Arroja, Carsten Tschöpe, Miłosz Jaguszewski, Repositório da Universidade de Lisboa, Jurisic, S, Gili, S, Cammann, Vl, Kato, K, Szawan, Ka, D'Ascenzo, F, Jaguszewski, M, Bossone, E, Citro, R, Sarcon, A, Napp, Lc, Franke, J, Noutsias, M, Knorr, M, Heiner, S, Burgdorf, C, Koenig, W, Pott, A, Kherad, B, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Meyer, P, Arroja, Jd, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Dworakowski, R, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Beug, D, Delmas, C, Lairez, O, Kozel, M, Tousek, P, Winchester, De, Gilyarova, E, Shilova, A, Gilyarov, M, El-Battrawy, I, Akin, I, Galuszka, J, Ukena, C, Poglajen, G, Paolini, C, Bilato, C, Carrilho-Ferreira, P, Pinto, Fj, Opolski, G, Maccarthy, P, Kobayashi, Y, Prasad, A, Rihal, C, Widimsky, P, Horowitz, Jd, Di Mario, C, Crea, F, Tschope, C, Pieske, Bm, Hasenfuss, G, Rottbauer, W, Braun-Dullaeus, Rc, Felix, Sb, Borggrefe, M, Thiele, H, Bauersachs, J, Katus, Ha, Schunkert, H, Munzel, T, Bohm, M, Bax, Jj, Luscher, Tf, Ruschitzka, F, Ghadri, Jr, and Templin, C

Subjects
Male, medicine.medical_specialty, Time Factors, outcome, recovery, takotsubo syndrome, wall motion abnormalities, MEDLINE, 030204 cardiovascular system & hematology, Wall motion abnormalities, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Recovery, Medicine, Humans, 030212 general & internal medicine, Wall motion, Prospective Studies, Registries, Intensive care medicine, Aged, Retrospective Studies, Original Research, Outcome, Heart Failure, Takotsubo syndrome, business.industry, Creative commons, Recovery of Function, Middle Aged, Prognosis, 3. Good health, ddc, Female, Cardiology and Cardiovascular Medicine, business, Switzerland
Abstract

© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes., Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide‐ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut‐off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In‐hospital outcomes and 1‐year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1‐year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction, Christian Templin was supported by the H.H. Sheikh Khalifa bin Hamad Al‐Thani Research Programme and the Swiss Heart Foundation. The InterTAK Registry is supported by the Biss Davies Charitable Trust.

Published
2019

26. Coexistence and outcome of coronary artery disease in Takotsubo syndrome

Author

Jelena R. Ghadri, Pedro Carrilho-Ferreira, Wolfgang Koenig, Carla Paolini, Adrian P. Banning, Alessandro Cuneo, Jeroen J. Bax, Petr Widimský, Manfred Wischnewsky, Yoichi Imori, Hugo A. Katus, Paul Bridgman, Martin Borggrefe, Tuija Vasankari, David E. Winchester, Annahita Sarcon, Abhiram Prasad, Alexander Pott, Claudius Jacobshagen, Sebastiano Gili, John D. Horowitz, Heribert Schunkert, Frank Ruschitzka, Stephan B. Felix, Michael Böhm, Guido Michels, Lars S. Maier, Fausto J. Pinto, Carlo Di Mario, Ruediger C. Braun-Dullaeus, Thomas F. Lüscher, Philippe Meyer, Lawrence Rajan, Burkert Pieske, Thomas Münzel, Stefan Osswald, Gerd Hasenfuß, Rodolfo Citro, Olivier Lairez, Mahir Karakas, Florim Cuculi, Christian Ukena, Victoria L. Cammann, Alexandra Shilova, Jose David Arroja, Leonarda Galiuto, Grzegorz Opolski, Christoph Kaiser, Wolfgang Rottbauer, Christian Templin, Carsten Tschöpe, Ibrahim Akin, Ioana Sorici-Barb, Susanne Heiner, Jennifer Franke, Fabrizio D'Ascenzo, Johann Bauersachs, Richard Kobza, Christof Burgdorf, Michael Neuhaus, P. Christian Schulze, Daniel Beug, Petr Tousek, Filippo Crea, Monika Budnik, Miłosz Jaguszewski, Roman Pfister, Konrad A. Szawan, Ekaterina Gilyarova, Philip MacCarthy, Wolfgang Dichtl, Yoshio Kobayashi, Jan Galuszka, Michel Noutsias, Christina Chan, Thomas Fischer, Matteo Bianco, Ibrahim El-Battrawy, L. Christian Napp, Holger Thiele, Karolina Polednikova, Claudio Bilato, Charanjit S. Rihal, Clément Delmas, Rafal Dworakowski, Mikhail Gilyarov, Eduardo Bossone, Gregor Poglajen, Behrouz Kherad, Ken Kato, Christian Hauck, Maike Knorr, Eugene Braunwald, K.E. Juhani Airaksinen, Christian Napp, L., Cammann, V. L., Jaguszewski, M., Szawan, K. A., Wischnewsky, M., Gili, S., Knorr, M., Heiner, S., Citro, R., Bossone, E., D'Ascenzo, F., Neuhaus, M., Franke, J., Sorici-Barb, I., Noutsias, M., Burgdorf, C., Koenig, W., Kherad, B., Sarcon, A., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Pott, A., Meyer, P., Arroja, J. D., Banning, A., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Juhani Airaksinen, K. E., Hauck, C., Paolini, C., Bilato, C., Imori, Y., Kato, K., Kobayashi, Y., Opolski, G., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Dichtl, W., Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., El-Battrawy, I., Akin, I., Gilyarova, E., Shilova, A., Gilyarov, M., Horowitz, J. D., Polednikova, K., Tousek, P., Widimsky, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Mario, C. D., Prasad, A., Rihal, C. S., Christian Schulze, P., Bianco, M., Crea, F., Borggrefe, M., Maier, L. S., Pinto, F. J., Braun-Dullaeus, R. C., Rottbauer, W., Katus, H. A., Hasenfuss, G., Tschope, C., Pieske, B. M., Thiele, H., Schunkert, H., Bohm, M., Felix, S. B., Munzel, T., Bax, J. J., Bauersachs, J., Braunwald, E., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Acute coronary syndrome, medicine.medical_treatment, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Acute Coronary Syndrome, 10. No inequality, Cardiac catheterization, Outcome, medicine.diagnostic_test, business.industry, Incidence, Percutaneous coronary intervention, medicine.disease, 3. Good health, Coronary occlusion, Heart failure, Angiography, Cardiology, Cardiology and Cardiovascular Medicine, business, Takotsubo syndrome
Abstract

Copyright © 2020 European Society of Cardiology, Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. Methods and results: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort. Conclusions: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.

Published
2019

27. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Author

Petr Widimský, Katharina J. Ding, Sebastiano Gili, L. Christian Napp, Holger Thiele, Stephan B. Felix, Christof Burgdorf, Thomas F. Lüscher, Johann Bauersachs, Mahir Karakas, Alexandra Shilova, Davide Di Vece, Gerd Hasenfuß, Miłosz Jaguszewski, Roman Pfister, Thomas Münzel, Hugo A. Katus, David E. Winchester, Stefan Osswald, Thomas Fischer, Guido Michels, Ruediger C. Braun-Dullaeus, Adrian P. Banning, Philip MacCarthy, Stjepan Jurisic, Burkert Pieske, Christian Ukena, Fabrizio D'Ascenzo, Christoph Kaiser, Michael Böhm, Olivier Lairez, Rodolfo Citro, Richard Kobza, Antonio H. Frangieh, John D. Horowitz, Leonarda Galiuto, Grzegorz Opolski, Susanne Heiner, Filippo Crea, Beatrice Bacchi, Annahita Sarcon, Jeroen J. Bax, Wolfgang Dichtl, Victoria L. Cammann, Jelena R. Ghadri, Ekaterina Gilyarova, Wolfgang Rottbauer, Frank Ruschitzka, Ibrahim Akin, Ibrahim El-Battrawy, Martin Borggrefe, Jozef Micek, Clément Delmas, Lawrence Rajan, Rafal Dworakowski, Mikhail Gilyarov, Christian Templin, Petr Tousek, Jerold S. Shinbane, Tuija Vasankari, Michel Noutsias, Heribert Schunkert, Wolfgang Koenig, Eduardo Bossone, Abhiram Prasad, Carlo Di Mario, Alessandro Cuneo, Ken Kato, Martin Kozel, Konrad A. Szawan, Florim Cuculi, Maike Knorr, K.E. Juhani Airaksinen, Jennifer Franke, Carsten Tschöpe, Burkhardt Seifert, Claudius Jacobshagen, Cammann, Vl, Sarcon, A, Ding, Kj, Seifert, B, Kato, K, Di Vece, D, Szawan, Ka, Gili, S, Jurisic, S, Bacchi, B, Micek, J, Frangieh, Ah, Napp, Lc, Jaguszewski, M, Bossone, E, Citro, R, D'Ascenzo, F, Franke, J, Noutsias, M, Knorr, M, Heiner, S, Burgdorf, C, Koenig, W, Thiele, H, Tschope, C, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Dworakowski, R, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Delmas, C, Lairez, O, Horowitz, Jd, Kozel, M, Widimsky, P, Tousek, P, Winchester, De, Gilyarova, E, Shilova, A, Gilyarov, M, El-Battrawy, I, Akin, I, Ukena, C, Bauersachs, J, Pieske, Bm, Hasenfuss, G, Rottbauer, W, Braun-Dullaeus, Rc, Opolski, G, Maccarthy, P, Felix, Sb, Borggrefe, M, Di Mario, C, Crea, F, Katus, Ha, Schunkert, H, Munzel, T, Bohm, M, Bax, Jj, Prasad, A, Shinbane, J, Luscher, Tf, Ruschitzka, F, Ghadri, Jr, and Templin, C

Subjects
medicine.medical_specialty, Acute coronary syndrome, acute coronary syndrome, broken heart syndrome, cancer, malignancy, outcome, takotsubo syndrome, 030204 cardiovascular system & hematology, Malignancy, Broken heart syndrome, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Neoplasms, Internal medicine, medicine, Humans, In patient, Registries, 030212 general & internal medicine, Original Research, Heart Failure, Takotsubo syndrome, business.industry, Cancer, medicine.disease, ddc, 3. Good health, Clinical trial, Cohort, Cardiology and Cardiovascular Medicine, business
Abstract

Background Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short‐ and long‐term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short‐ and long‐term mortality. A subanalysis was performed comparing long‐term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long‐term mortality was higher in patients with malignancy (P, See Editorial Angelini and Uribe

Published
2019

28. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry

Author

David E. Winchester, Philip MacCarthy, Leonarda Galiuto, Guido Michels, Hugo A. Katus, Grzegorz Opolski, Susanne Heiner, Burkert Pieske, Christian Ukena, Wolfgang Koenig, Richard Kobza, Sebastiano Gili, Christoph Kaiser, Eduardo Bossone, Beatrice Bacchi, Johann Bauersachs, Filippo Crea, K.E. Juhani Airaksinen, Konrad A. Szawan, Heribert Schunkert, Abhiram Prasad, Carlo Di Mario, John D. Horowitz, L. Christian Napp, Holger Thiele, Gerd Hasenfuß, Rafal Dworakowski, Ekaterina Gilyarova, Roman Pfister, Christof Burgdorf, Christian Templin, Flurina Famos, Stjepan Jurisic, Victoria L. Cammann, Stefan Osswald, Miłosz Jaguszewski, Maike Knorr, Wolfgang Rottbauer, Alexandra Shilova, Ibrahim Akin, Petr Tousek, Jeroen J. Bax, Adrian P. Banning, Lawrence Rajan, Alessandro Cuneo, Davide Di Vece, Claudius Jacobshagen, Katharina J. Ding, Susanne A. Schlossbauer, Jennifer Franke, Ruediger C. Braun-Dullaeus, Manfred Wischnewsky, Klaus Empen, Michael Böhm, Carsten Tschöpe, Petr Widimský, Stephan B. Felix, Olivier Lairez, Burkhardt Seifert, Thomas Münzel, Michel Noutsias, Tuija Vasankari, Thomas F. Lüscher, Ibrahim El-Battrawy, Slayman Obeid, Fabrizio D'Ascenzo, Florim Cuculi, Mikhail Gilyarov, Rodolfo Citro, Mahir Karakas, Ken Kato, Jozef Micek, Fiorenzo Gaita, Martin Kozel, Wolfgang Dichtl, Clément Delmas, Rena A. Levinson, Samir M. Said, Olivia Lenoir, Annahita Sarcon, Thomas Fischer, Jelena R. Ghadri, Martin Borggrefe, Frank Ruschitzka, Gili, S, Cammann, Vl, Schlossbauer, Sa, Kato, K, D'Ascenzo, F, Di Vece, D, Jurisic, S, Micek, J, Obeid, S, Bacchi, B, Szawan, Ka, Famos, F, Sarcon, A, Levinson, R, Ding, Kj, Seifert, B, Lenoir, O, Bossone, E, Citro, R, Franke, J, Napp, Lc, Jaguszewski, M, Noutsias, M, Munzel, T, Knorr, M, Heiner, S, Katus, Ha, Burgdorf, C, Schunkert, H, Thiele, H, Bauersachs, J, Tschope, C, Pieske, Bm, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Hasenfuss, G, Karakas, M, Koenig, W, Rottbauer, W, Said, Sm, Braun-Dullaeus, Rc, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Crea, F, Dichtl, W, Empen, K, Felix, Sb, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Borggrefe, M, Gilyarova, E, Shilova, A, Gilyarov, M, Horowitz, Jd, Kozel, M, Tousek, P, Widimsky, P, Winchester, De, Ukena, C, Gaita, F, Di Mario, C, Wischnewsky, Mb, Bax, Jj, Prasad, A, Bohm, M, Ruschitzka, F, Luscher, Tf, Ghadri, Jr, and Templin, C

Subjects
Male, Tachycardia, Acute heart failure, Broken heart syndrome, Cardiac arrest, Outcome, Takotsubo syndrome, medicine.medical_specialty, Cardiomyopathy, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Takotsubo Cardiomyopathy, Internal medicine, Humans, Medicine, Registries, 030212 general & internal medicine, Asystole, Retrospective Studies, Ejection fraction, business.industry, Atrial fibrillation, Middle Aged, Prognosis, medicine.disease, Survival Analysis, ddc, Heart Arrest, 3. Good health, Editor's Choice, Editorial, Pulseless electrical activity, Ventricular fibrillation, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Aims We aimed to evaluate the frequency, clinical features, and prognostic implications of cardiac arrest (CA) in takotsubo syndrome (TTS). Methods and results We reviewed the records of patients with CA and known heart rhythm from the International Takotsubo Registry. The main outcomes were 60-day and 5-year mortality. In addition, predictors of mortality and predictors of CA during the acute TTS phase were assessed. Of 2098 patients, 103 patients with CA and known heart rhythm during CA were included. Compared with patients without CA, CA patients were more likely to be younger, male, and have apical TTS, atrial fibrillation (AF), neurologic comorbidities, physical triggers, and longer corrected QT-interval and lower left ventricular ejection fraction on admission. In all, 57.1% of patients with CA at admission had ventricular fibrillation/tachycardia, while 73.7% of patients with CA in the acute phase had asystole/pulseless electrical activity. Patients with CA showed higher 60-day (40.3% vs. 4.0%, P Conclusions Cardiac arrest is relatively frequent in TTS and is associated with higher short- and long-term mortality. Clinical and electrocardiographic parameters independently predicted mortality after CA.

Published
2019

30. Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

Author

Cammann, Victoria L, Scheitz, Jan F., Ghadri, Jelena R, Budnik, Monika, Opolski, Grzegorz, Borggrefe, Martin, Thiele, Holger, Bauersachs, Johann, Katus, Hugo A, Horowitz, John D, Di Mario, Carlo, Münzel, Thomas, Crea, Filippo, Consortium, InterTAK, Bax, Jeroen J, Scherff, Frank, Niederseer, David, Lüscher, Thomas F, Citro, Rodolfo, Vecchione, Carmine, Bossone, Eduardo, Gili, Sebastiano, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Miłosz, von Rennenberg, Regina, Noutsias, Michel, Knorr, Maike, Jansen, Thomas, D'Ascenzo, Fabrizio, Dichtl, Wolfgang, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Jäncke, Lutz, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang, Pott, Alexander, Meyer, Philippe, Roffi, Marco, Nolte, Christian, Banning, Adrian, Wolfrum, Mathias, Cuculi, Florim, Kobza, Richard, Fischer, Thomas, Vasankari, Tuija, Airaksinen, K E Juhani, Napp, L Christian, Dworakowski, Rafal, MacCarthy, Philip, Szawan, Konrad A, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clément, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Stengl, Helena, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Poledniková, Karolina, Toušek, Petr, Winchester, David E, Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Würdinger, Michael, Hauck, Christian, Paolini, Carla, Bilato, Claudio, Kobayashi, Yoshio, Kato, Ken, Shoji, Toshihiro, Ishibashi, Iwao, Takahara, Masayuki, Himi, Toshiharu, Din, Jehangir, Endres, Matthias, Al-Shammari, Ali, Prasad, Abhiram, Rihal, Charanjit S, Liu, Kan, Schulze, Peter, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Pestana, Gonçalo, Nguyen, Thanh H, Templin, Christian, Böhm, Michael, Maier, Lars S, Pinto, Fausto J, Widimský, Petr, Felix, Stephan B, Braun-Dullaeus, Ruediger C, Rottbauer, Wolfgang, Hasenfuß, Gerd, Pieske, Burkert M, Schunkert, Heribert, University of Zurich, and Repositório da Universidade de Lisboa

Subjects
Adult, Male, Science, Cardiology, heart disease risk factors, complications [Seizures], Article, Seizures, Takotsubo Cardiomyopathy, diagnosis [Takotsubo Cardiomyopathy], Humans, Hospital Mortality, Registries, humans, Ischemic Stroke, Aged, Aged, 80 and over, hospital mortality, mortality [Takotsubo Cardiomyopathy], Multidisciplinary, complications [Intracranial Hemorrhages], 10093 Institute of Psychology, etiology [Takotsubo Cardiomyopathy], Middle Aged, Prognosis, complications [Ischemic Stroke], Outcomes research, Heart Disease Risk Factors, 10209 Clinic for Cardiology, Medicine, Female, 150 Psychology, Intracranial Hemorrhages, ddc:600
Abstract

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/., Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness., The International Takotsubo Registry was supported by the Biss Davies Charitable Trust. Dr. Scheitz has been supported by the Corona Foundation. Dr. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation.

Published
2021
Full Text
View/download PDF

31. Impact of atrial fibrillation on outcome in takotsubo syndrome: Data from the international Takotsubo registry

Author

Stefan Osswald, Yoshio Kobayashi, Kan Liu, Sebastiano Gili, Christina Chan, John D. Horowitz, Aurelio Rossi, Jeroen J. Bax, Alessandro Cuneo, Claudio Bilato, Olivier Lairez, Abhiram Prasad, Carlo Di Mario, Alexandra Shilova, Davide Di Vece, Christof Burgdorf, Leonarda Galiuto, Grzegorz Opolski, Michael Neuhaus, Gerd Hasenfuß, Manfred Wischnewsky, Wolfgang Koenig, L. Christian Napp, Holger Thiele, David E. Winchester, Susanne Heiner, Guido Michels, Benjamin Meder, Lawrence Rajan, Hans Rickli, Tuija Vasankari, Jose David Arroja, Lucas Jörg, Victoria L. Cammann, Burkert Pieske, Jelena R. Ghadri, Hugo A. Katus, Carsten Tschöpe, Thomas Fischer, Paul Bridgman, Matteo Bianco, Christian Ukena, P. Christian Schulze, Julia Hermes-Laufer, Florim Cuculi, Jan Galuszka, Christoph Kaiser, Wolfgang Rottbauer, Mahir Karakas, Ibrahim El-Battrawy, Michel Noutsias, Richard Kobza, Ibrahim Akin, Martin Borggrefe, Fausto J. Pinto, Stephan B. Felix, Carla Paolini, Rafal Dworakowski, Charanjit S. Rihal, Johann Bauersachs, Pedro Carrilho-Ferreira, Rodolfo Citro, Thanh H Nguyen, Thomas Münzel, Thomas F. Lüscher, Firat Duru, Wolfgang Dichtl, Philip MacCarthy, Roman Pfister, Heribert Schunkert, Clément Delmas, Monika Budnik, Konrad A. Szawan, Miłosz Jaguszewski, Filippo Crea, Christian Templin, Mikhail Gilyarov, Ruediger C. Braun-Dullaeus, Gonçalo Pestana, Petr Tousek, Lars S. Maier, Philippe Meyer, Ekaterina Gilyarova, Frank Ruschitzka, Adrian P. Banning, Michael Böhm, K.E. Juhani Airaksinen, Christian Hauck, Maike Knorr, Fabrizio D'Ascenzo, Annahita Sarcon, Jennifer Franke, Daniel Beug, Alexander Pott, Claudius Jacobshagen, Petr Widimský, Behrouz Kherad, Ken Kato, Martin Kozel, Eduardo Bossone, Gregor Poglajen, Jerold S. Shinbane, and Repositório da Universidade de Lisboa

Subjects
Male, Time Factors, medicine.medical_treatment, 030204 cardiovascular system & hematology, Cardioversion, 0302 clinical medicine, Patient Admission, Risk Factors, Atrial Fibrillation, Prevalence, 80 and over, 030212 general & internal medicine, Hospital Mortality, Prospective Studies, Registries, Original Research, Outcome, Aged, 80 and over, Broken heart syndrome, Ejection fraction, Mortality rate, Hazard ratio, Atrial fibrillation, Middle Aged, Prognosis, Europe, Cohort, atrial fibrillation, broken heart syndrome, outcome, takotsubo syndrome, Cardiology, Female, Cardiology and Cardiovascular Medicine, Takotsubo syndrome, medicine.medical_specialty, Risk Assessment, 03 medical and health sciences, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, Risk factor, Aged, Retrospective Studies, Heart Failure, business.industry, Proportional hazards model, medicine.disease, United States, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, business
Abstract

Copyright © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes., Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the International Takotsubo Registry, which is a multinational network with 26 participating centers in Europe and the United States. Patients were dichotomized according to the presence or absence of AF at the time of admission. Of 1584 patients with TTS, 112 (7.1%) had AF. The mean age was higher (P

Published
2021

32. Twirling around the block-A complex case of cardiac sarcoidosis

Author

Christopher C. Cheung, Bernard Belhassen, Annahita Sarcon, and Melvin M. Scheinman

Subjects
medicine.medical_specialty, Sarcoidosis, business.industry, Cardiac sarcoidosis, Middle Aged, medicine.disease, Electrocardiography, Heart Block, Heart Conduction System, Physiology (medical), Internal medicine, Block (telecommunications), Cardiology, medicine, Humans, Female, Cardiology and Cardiovascular Medicine, business, Atrioventricular block, Conduction disease
Published
2020

33. B-PO02-178 FEASIBILITY OF ENDOCARDIAL AND EPICARDIAL RECORDING, MAPPING AND ABLATION DURING MECHANICAL CIRCULATORY SUPPORT USING THE NEW PERCUTANEOUS HEART PUMP (PHP) IN SIMULATED VENTRICULAR TACHYCARDIA/FLUTTER AND VENTRICULAR FIBRILLATION

Author

Anna Sarcon, Maheer Gandhavadi, Arash Aryana, P. Gearoid O’Neill, Andre d'Avila, and Mark R. Bowers

Subjects
medicine.medical_specialty, Percutaneous, business.industry, medicine.medical_treatment, Ablation, Ventricular tachycardia, medicine.disease, Physiology (medical), Internal medicine, Circulatory system, Ventricular fibrillation, medicine, Cardiology, Flutter, Cardiology and Cardiovascular Medicine, business
Published
2021
Full Text
View/download PDF

34. Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Roman Pfister, Florim Cuculi, Stefan Osswald, Michel Noutsias, Klaus Empen, Annahita Sarcon, Philip MacCarthy, Alessandro Cuneo, Tuija Vasankari, Ruediger C. Braun-Dullaeus, Alessandro Candreva, Rodolfo Citro, Mahir Karakas, Katharina J. Ding, Christian Templin, Wolfgang Koenig, Petr Tousek, L. Christian Napp, Fabrizio D'Ascenzo, Petr Widimský, Samir M. Said, Richard Kobza, Olivier Lairez, Holger Thiele, K.E. Juhani Airaksinen, Beatrice Bacchi, Abhiram Prasad, Carlo Di Mario, David E. Winchester, Eduardo Bossone, Filippo Crea, Claudius Jacobshagen, Heribert Schunkert, Guido Michels, Alexandra Shilova, Sebastiano Gili, Jozef Micek, Ekaterina Gilyarova, Konrad A. Szawan, Davide Di Vece, Burkert Pieske, Carsten Tschöpe, Thomas Fischer, Thomas Münzel, Christian Ukena, Christoph Kaiser, Adrian P. Banning, Stephan B. Felix, Jennifer Franke, John D. Horowitz, Thomas F. Lüscher, Hugo A. Katus, Jelena-R. Ghadri, Christof Burgdorf, Ken Kato, Martin Borggrefe, Michael Böhm, Miłosz Jaguszewski, Martin Kozel, Frank Ruschitzka, Maike Knorr, Victoria L. Cammann, Ibrahim El-Battrawy, Wolfgang Rottbauer, Moritz Schwyzer, Stjepan Jurisic, Ibrahim Akin, Clément Delmas, Mikhail Gilyarov, Jeroen J. Bax, Leonarda Galiuto, Grzegorz Opolski, Susanne Heiner, Johann Bauersachs, Gerd Hasenfuβ, Rafal Dworakowski, Lawrence Rajan, Wolfgang Dichtl, Di Vece, D, Citro, R, Cammann, Vl, Kato, K, Gili, S, Szawan, Ka, Micek, J, Jurisic, S, Ding, Kj, Bacchi, B, Schwyzer, M, Candreva, A, Bossone, E, D'Ascenzo, F, Sarcon, A, Franke, J, Napp, Lc, Jaguszewski, M, Noutsias, M, Munzel, T, Knorr, M, Heiner, S, Katus, Ha, Burgdorf, C, Schunkert, H, Thiele, H, Bauersachs, J, Tschope, C, Pieske, Bm, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Hasenfuss, G, Karakas, M, Koenig, W, Rottbauer, W, Said, Sm, Braun-Dullaeus, Rc, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kj, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Crea, F, Dichtl, W, Empen, K, Felix, Sb, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Borggrefe, M, Gilyarova, E, Shilova, A, Gilyarov, M, Horowitz, J, Kozel, M, Tousek, P, Widimsky, P, Winchester, De, Ukena, C, Di Mario, C, Prasad, A, Bohm, M, Bax, Jj, Luscher, Tf, Ruschitzka, F, Ghadri, Jr, and Templin, C

Subjects
Male, medicine.medical_specialty, Time Factors, Comorbidity, 030204 cardiovascular system & hematology, Risk Assessment, Broken heart syndrome, 03 medical and health sciences, 0302 clinical medicine, Informed consent, Risk Factors, Takotsubo Cardiomyopathy, Physiology (medical), cardiac mechanical support, Medicine, Humans, takotsubo syndrome, 030212 general & internal medicine, Hospital Mortality, Prospective Studies, Registries, broken heart syndrome, cardiogenic shock, outcome, Aged, Female, Middle Aged, Prognosis, Retrospective Studies, Shock, Cardiogenic, Takotsubo syndrome, business.industry, Cardiogenic shock, Incidence (epidemiology), Medical record, Ethics committee, Shock, ta3121, medicine.disease, Cardiogenic, 3. Good health, Emergency medicine, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Observational study, Cardiology and Cardiovascular Medicine, business
Abstract

The clinical course of takotsubo syndrome (TTS) can be complicated by several life-threatening conditions. In particular, cardiogenic shock (CS) represents one of the leading causes of mortality in the acute phase and occurs in a considerable number of patients with TTS, with an incidence of ≈10%. At present, no established guidelines are available to support specific treatment recommendations,and the conventional therapy for CS leads to uncertain results in TTS cases. The International Takotsubo Registry (www.takotsubo-registry.com) is an observational, prospective, and retrospective registry established at the University Hospital Zurich in 2011, with the largest TTS database worldwide. Patients were included in the registry between 2011 and 2017 based on modified Mayo Clinic Diagnostic criteria. Hospitalization data were recorded through standardized forms on admission or during revision of clinical charts; follow-up data were obtained from medical records, telephone follow-up, or clinical visits. The study population was categorized into 2 groups: patients with TTS with and without CS. The study protocol was reviewed by the respective local ethics committees or investigational review boards at each collaboration site. Where informed consent was required, formal written consent was obtained from patients.

Published
2019

35. Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry

Author

D'Ascenzo, Fabrizio, Gili, Sebastiano, Bertaina, Maurizio, Iannaccone, Mario, Cammann, Victoria L, Di Vece, Davide, Kato, Ken, Saglietto, Andrea, Szawan, Konrad A, Frangieh, Antonio H, Boffini, Beatrice, Annaratone, Margherita, Sarcon, Annahita, Levinson, Rena A, Franke, Jennifer, Napp, L Christian, Jaguszewski, Milosz, Noutsias, Michel, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, Katus, Hugo A, Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschöpe, Carsten, Pieske, Burkert M, Rajan, Lawrence, Michels, Guido, et al, University of Zurich, and D'Ascenzo, Fabrizio

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2020

36. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry

Author

Gili, Sebastiano, Cammann, Victoria L, Schlossbauer, Susanne A, Kato, Ken, D'Ascenzo, Fabrizio, Di Vece, Davide, Jurisic, Stjepan, Micek, Jozef, Obeid, Slayman, Bacchi, Beatrice, Szawan, Konrad A, Famos, Flurina, Sarcon, Annahita, Levinson, Rena, Ding, Katharina J, Seifert, Burkhardt, Lenoir, Olivia, Bossone, Eduardo, Citro, Rodolfo, Franke, Jennifer, Napp, L Christian, Jaguszewski, Milosz, Noutsias, Michel, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, Katus, Hugo A, Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, et al, and University of Zurich

Subjects
11459 Center for Molecular Cardiology, 10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2019

37. Augmented Spring Ligament Repair in Pes Planovalgus Reconstruction

Author

Jesse F. Doty, Patrick Michelier, Christopher Kreulen, Jason Fogleman, Aida K. Sarcon, and Eric Giza

Subjects
medicine.medical_specialty, Spring ligament, Radiography, medicine.medical_treatment, Triple arthrodesis, 03 medical and health sciences, 0302 clinical medicine, Suture (anatomy), medicine, Deformity, Humans, Orthopedics and Sports Medicine, 030222 orthopedics, Sutures, business.industry, Foot, 030229 sport sciences, Flatfoot, Surgery, medicine.anatomical_structure, Concomitant, Ligaments, Articular, Ligament, medicine.symptom, business, Pes planovalgus
Abstract

Patients with pes planovalgus deformity often have coexisting spring ligament pathology. A primary repair of the ligament may fail during weightbearing due to chronic degeneration of the ligamentous tissue. Augmentation with a suture tape has been suggested to strengthen the repair. Limited data exist regarding flatfoot reconstruction with augmented spring ligament repair using a suture tape. This is a review of 57 consecutive patients who had flatfoot reconstruction with concomitant spring ligament augmented repair between July 2014 and August 2017. Weightbearing radiographic parameters were obtained preoperatively and compared to radiographs at an average time of 62 ± 46.5 (range 20-220) weeks postoperative. Significant improvements were seen in the radiographic parameters evaluated. Five patients had subsequent operations including one deep infection, 2 hardware removals remote to the spring ligament augmentation, 1 ankle arthrodesis, and 1 triple arthrodesis. Concomitant spring ligament repair augmented with a suture tape was a safe procedure that contributed to radiographic correction in a consecutive series of 57 patients undergoing flatfoot deformity correction.

Published
2019

39. Is suffering from chronic pain causing cardiovascular death?

Author

Jelena R. Ghadri, Christian Templin, and Annahita Sarcon

Subjects
medicine.medical_specialty, business.industry, Chronic pain, medicine.disease, Cardiovascular death, Cardiovascular Diseases, Risk Factors, Internal medicine, medicine, Humans, Longitudinal Studies, Chronic Pain, Cardiology and Cardiovascular Medicine, business
Published
2019

40. Lateral Ankle Sprain and Chronic Ankle Instability

Author

Nasser Heyrani, Aida K. Sarcon, Eric Giza, and Christopher Kreulen

Subjects
medicine.medical_specialty, Lateral ankle, ankle instability, Bioengineering, sprain, 03 medical and health sciences, chronic ankle instability, 0302 clinical medicine, Physical medicine and rehabilitation, lcsh:Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Topical Review, Ankle instability, 030222 orthopedics, screening and diagnosis, business.industry, 030229 sport sciences, arthroscopic Brostrom, 4.1 Discovery and preclinical testing of markers and technologies, lcsh:RD701-811, Detection, medicine.anatomical_structure, Chronic ankle instability, Ankle, business, lateral ligament, modified Brostrom
Abstract

A select 10-30% of patients with recurrent lateral ankle sprains develop chronic ankle instability (CAI). Patients with chronic ankle instability describe a history of the ankle “giving way” with or without pathological laxity on examination. Evaluation includes history, identification of predisposing risk factors for recurrent sprains, and the combination of clinical tests (eg, laxity tests) with imaging to establish the diagnosis. There are a variety of nonoperative strategies to address chronic ankle instability, which include rehabilitation and taping or bracing to prevent future sprains. Patients who fail conservative treatment are candidates for surgery. The anatomic approaches (eg, modified Broström) are preferred to nonanatomic procedures since they recreate the ankle’s biomechanics and natural course of the attenuated ligaments. There is a growing interest in minimally invasive procedures via ankle arthroscopy that also address the associated intra-articular disorders. This article provides a review of chronic lateral ankle instability consisting of relevant anatomy, associated disorders, evaluation, treatment methods, and complications.Level of Evidence:Level V, expert opinion.

Published
2019

41. Arthroscopic all-inside ATiFL’s distal fascicle transfer for ATFL’s superior fascicle reconstruction or biological augmentation of lateral ligament repair

Author

Francesc Malagelada, Miki Dalmau-Pastor, Aida K. Sarcon, Daniel Poggio, Matteo Guelfi, Jordi Vega, and Nasser Heyrani

Subjects
Joint Instability, Male, Tendon Entrapment, Anterior tibiofibular ligament, Arthroplasty, Talus, Arthroscopy, medicine.ligament, Cadaver, medicine, Humans, Orthopedics and Sports Medicine, Ankle Injuries, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Suture Techniques, Anterior talofibular ligament, Anatomy, Middle Aged, Fascicle, musculoskeletal system, Tendon, medicine.anatomical_structure, Chronic Disease, Ligament, Female, Surgery, Ankle, Lateral Ligament, Ankle, business, Ankle Joint
Abstract

Tendon grafts are often utilized for reconstruction of the lateral ligaments unamenable to primary repair. However, tendon and ligaments have different biological roles. The anterior tibiofibular ligament’s (ATiFL) distal fascicle may be resected without compromising the stability of the ankle joint. The aim of this study is to describe an all-arthroscopic and intra-articular surgical technique of ATiFL’s distal fascicle transfer for the treatment of chronic ankle instability. Five unpaired cadaver ankles underwent arthroscopic ATiFL’s distal fascicle transfer using a non-absorbable suture and a knotless anchor. Injured or absent ATiFL’s distal fascicle were excluded from the study. Following arthroscopy, the ankles were dissected and evaluated for entrapment of nearby adjacent anatomical structures. The ligament transfer was also assessed. The distance between the anterolateral (AL) portals and the superficial peroneal nerve (SPN) was measured and the shortest distance was reported. All specimens revealed successful transfer of the tibial origin of the ATiFL’s distal fascicle onto the talar insertion of anterior talofibular ligament’s (ATFL) superior fascicle. The fibular origin of the ATiFL’s distal fascicle remained intact. There were no specimens with SPN or extensor tendon entrapment. The median distance between the proximal AL portal and SPN was 3.8 mm. The median distance between the distal AL portal and SPN was 3.9 mm. An all-arthroscopic approach to an ATiFL’s distal fascicle transfer is a reliable method to reconstruct the ATFL’s superior fascicle. Transfer of ATiFL’s distal fascicle avoids the need for tendon harvest or allograft. The lack of injury to nearby adjacent structures suggests that it is a safe procedure. The clinical relevance of the study is that ATiFL’s distal fascicle can be arthroscopically transferred to be used as a biological reinforcement of the ATFL repair, or as an ATFL reconstruction.

Published
2019
Full Text
View/download PDF

42. B-PO03-098 A NOVEL SINGLE-SHOT PULSED FIELD ABLATION SYSTEM IS ASSOCIATED WITH LARGE AND DURABLE LESIONS IN VIVO WITHOUT ADVERSE EFFECTS ON THE ADJACENT PHRENIC NERVE OR ESOPHAGUS

Author

Alan de la Rama, Ken Nguyen, Arash Aryana, Anna Sarcon, Andre d'Avila, Taylor Spangler, Dorin Panescu, and Cary Hata

Subjects
Field (physics), business.industry, medicine.medical_treatment, Single shot, Ablation, medicine.anatomical_structure, In vivo, Physiology (medical), medicine, Esophagus, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Adverse effect, Phrenic nerve
Published
2021
Full Text
View/download PDF

43. B-PO05-087 THE IMPACT OF PULSED FIELD ABLATION USING A NOVEL SINGLE-SHOT ABLATION SYSTEM ON THE ADJACENT ESOPHAGUS IN A PORCINE MODEL

Author

Cary Hata, Alan de la Rama, Anna Sarcon, Ken Nguyen, Dorin Panescu, Andre d'Avila, Arash Aryana, and Taylor Spangler

Subjects
Optics, medicine.anatomical_structure, Field (physics), business.industry, Physiology (medical), medicine.medical_treatment, medicine, Single shot, Esophagus, Cardiology and Cardiovascular Medicine, business, Ablation
Published
2021
Full Text
View/download PDF

44. A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry

Author

Burkhardt Seifert, Fabrizio D'Ascenzo, Katharina J. Ding, Annahita Sarcon, Elycia Kazemian, Tanja Birri, Jelena-R. Ghadri, Thomas F. Lüscher, L. Christian Napp, Victoria L. Cammann, Johanna Diekmann, InterTAK co-investigators, Dana Roxana Bataiosu, Christian Templin, Frank Ruschitzka, and Stjepan Jurisic

Subjects
medicine.medical_specialty, Takotsubo syndrome, Acute coronary syndrome, business.industry, Area under the curve, 030204 cardiovascular system & hematology, medicine.disease, Logistic regression, Confidence interval, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart failure, Cardiology, Medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Trial registration, Depression (differential diagnoses)
Abstract

Aims Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. Methods and results Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436). The best model was selected and formed a score (InterTAK Diagnostic Score) with seven variables, and each was assigned a score value: female sex 25, emotional trigger 24, physical trigger 13, absence of ST-segment depression (except in lead aVR) 12, psychiatric disorders 11, neurologic disorders 9, and QTc prolongation 6 points. The area under the curve (AUC) for the resulting score was 0.971 [95% confidence interval (CI) 0.96–0.98] and using a cut-off value of 40 score points, sensitivity was 89% and specificity 91%. When patients with a score of ≥50 were diagnosed as TTS, nearly 95% of TTS patients were correctly diagnosed. When patients with a score ≤31 were diagnosed as ACS, ∼95% of ACS patients were diagnosed correctly. The score was subsequently validated in an independent validation cohort (TTS, n = 173; ACS, n = 226), resulting in a score AUC of 0.901 (95% CI 0.87–0.93). Conclusion The InterTAK Diagnostic Score estimates the probability of the presence of TTS and is able to distinguish TTS from ACS with a high sensitivity and specificity. Trial registration: NCT0194762

Published
2016
Full Text
View/download PDF

45. Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Di Vece, Davide, Citro, Rodolfo, Cammann, Victoria L, Kato, Ken, Gili, Sebastiano, Szawan, Konrad A, Micek, Jozef, Jurisic, Stjepan, Ding, Katharina J, Bacchi, Beatrice, Schwyzer, Moritz, Candreva, Alessandro, Bossone, Eduardo, D'Ascenzo, Fabrizio, Sarcon, Annahita, Napp, L Christian, Jaguszewski, Milosz, Münzel, Thomas, Katus, Hugo A, Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Pieske, Burkert M, Lüscher, Thomas F, Ruschitzka, Frank, Ghadri, Jelena R, Templin, Christian, et al, University of Zurich, and Templin, Christian

Subjects
11459 Center for Molecular Cardiology, 2737 Physiology (medical), 10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2019
Full Text
View/download PDF

46. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Author

Cammann, Victoria Lucia, Sarcon, Annahita, Ding, Katharina J, Seifert, Burkhardt, Kato, Ken, Di Vece, Davide, Szawan, Konrad A, Gili, Sebastiano, Jurisic, Stjepan, Bacchi, Beatrice, Micek, Jozef, Frangieh, Antonio H, Napp, L Christian, Lüscher, Thomas F, Ruschitzka, Frank, Ghadri, Jelena R, Templin, Christian, et al, and University of Zurich

Subjects
11459 Center for Molecular Cardiology, 10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2019
Full Text
View/download PDF

47. A Prospective, Randomized Investigation of Syndesmosis Injury Fixation

Author

Patrick Barousse, Christopher Kreulen, Brett D. Crist, James A. Ronan, Ashoke Sathy, Todd Oliver, James P. Stannard, Johnny Lin, Trevor J. Shelton, Eric Giza, Gregory J. Della Rocca, Aida K. Sarcon, Wade Faerber, and Tyler Allen

Subjects
medicine.medical_specialty, Syndesmosis, education.field_of_study, business.industry, suture button, flexible fixation, Suture button, Population, ankle fracture, Article, Surgery, lcsh:RD701-811, Fixation (surgical), medicine.anatomical_structure, lcsh:Orthopedic surgery, medicine, Ankle, education, business
Abstract

Category: Ankle; Trauma Introduction/Purpose: Syndesmotic disruption occurs in 10 to 13% of all ankle fractures. It is present in 15 cases per 100,000 of the general population. There has been debate on the best treatment for syndesmotic injuries. The typical surgical treatments include fixation with either screws or suture button devices. The purpose of this study is to compare clinical outcomes of syndesmotic injuries treated surgically with either screws or suture button devices. It was hypothesized that suture button fixation would provide equal clinical results with less need for hardware removal. Methods: This was a multi-center, randomized, prospective clinical trial comparing two surgical interventions for treatment of acute syndesmotic injury. Subjects were placed into either screw fixation or the Suture-button device group. Subjects with clinical signs or radiographic evidence of syndesmotic injury were asked to participate in this study. Inclusion criteria was ages 18 to 65 years old with confirmed syndesmotic instability. The primary outcomes of the study were VAS scores (activity, pain, satisfaction) and FFI scores (pain, disability, activity) which were collected at preoperative state, 6 weeks, and 12 months postoperatively. Results: Sixty-five subjects were enrolled in this study. Thirty-two subjects received Suture-button fixation (49%) and 33 received screw fixation (51%). VAS scores and FFI scores for subjects treated with the Suture-button device or screw fixation comparing preoperative, six-week, and 12-month scores all showed clinical improvement. There was no significant difference between the two treatment groups (p >0.05).Nine subjects (27%) in the syndesmotic screw fixation group experienced adverse events, and only one subject (3%) in the suture-button group had adverse event. Conclusion: The short-term clinical outcomes suggest that both syndesmotic screws and suture-button devices are effective treatment options to address acute syndesmotic injuries. In the short-term (12-months), suture-button fixation resulted in significantly less adverse events compared to syndesmotic screw fixation group.

Published
2020
Full Text
View/download PDF

48. Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome

Author

Davide, Di Vece, Rodolfo, Citro, Victoria L, Cammann, Ken, Kato, Sebastiano, Gili, Konrad A, Szawan, Jozef, Micek, Stjepan, Jurisic, Katharina J, Ding, Beatrice, Bacchi, Moritz, Schwyzer, Alessandro, Candreva, Eduardo, Bossone, Fabrizio, D'Ascenzo, Annahita, Sarcon, Jennifer, Franke, L Christian, Napp, Milosz, Jaguszewski, Michel, Noutsias, Thomas, Münzel, Maike, Knorr, Susanne, Heiner, Hugo A, Katus, Christof, Burgdorf, Heribert, Schunkert, Holger, Thiele, Johann, Bauersachs, Carsten, Tschöpe, Burkert M, Pieske, Lawrence, Rajan, Guido, Michels, Roman, Pfister, Alessandro, Cuneo, Claudius, Jacobshagen, Gerd, Hasenfuβ, Mahir, Karakas, Wolfgang, Koenig, Wolfgang, Rottbauer, Samir M, Said, Ruediger C, Braun-Dullaeus, Adrian, Banning, Florim, Cuculi, Richard, Kobza, Thomas A, Fischer, Tuija, Vasankari, K E Juhani, Airaksinen, Grzegorz, Opolski, Rafal, Dworakowski, Philip, MacCarthy, Christoph, Kaiser, Stefan, Osswald, Leonarda, Galiuto, Filippo, Crea, Wolfgang, Dichtl, Klaus, Empen, Stephan B, Felix, Clément, Delmas, Olivier, Lairez, Ibrahim, El-Battrawy, Ibrahim, Akin, Martin, Borggrefe, Ekaterina, Gilyarova, Alexandra, Shilova, Mikhail, Gilyarov, John, Horowitz, Martin, Kozel, Petr, Tousek, Petr, Widimský, David E, Winchester, Christian, Ukena, Carlo, Di Mario, Abhiram, Prasad, Michael, Böhm, Jeroen J, Bax, Thomas F, Lüscher, Frank, Ruschitzka, Jelena R, Ghadri, and Christian, Templin

Subjects
Male, Time Factors, Shock, Cardiogenic, Comorbidity, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Takotsubo Cardiomyopathy, Humans, Female, Hospital Mortality, Prospective Studies, Registries, Aged, Retrospective Studies
Published
2018

49. P919Clinical characteristics of patients with cancer and takotsubo cardiomyopathy - Observations from the international takotsubo registry

Author

Thomas F. Lüscher, Victoria L. Cammann, Sebastiano Gili, Ken Kato, Frank Ruschitzka, Stjepan Jurisic, C Ghadri, Jerold S. Shinbane, Christian Templin, and Annahita Sarcon

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiomyopathy, Cancer, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2018
Full Text
View/download PDF

50. Gender disparities in acute coronary syndrome

Author

Jelena R. Ghadri, Milosz Jaguszewski, Lukas Baumann, Annahita Sarcon, Thomas F. Lüscher, Christian Templin, Johanna Diekmann, Jens P. Hellermann, Adam Csordas, Aline A. Schöni, Roxana D. Bataiosu, University of Zurich, and Templin, Christian

Subjects
Male, Acute coronary syndrome, medicine.medical_specialty, Statin, medicine.drug_class, Prohormone, 610 Medicine & health, Kaplan-Meier Estimate, Disease, 2705 Cardiology and Cardiovascular Medicine, Age Distribution, Percutaneous Coronary Intervention, Sex Factors, Internal medicine, medicine, Clinical endpoint, Humans, Hospital Mortality, Registries, Acute Coronary Syndrome, Coronary Artery Bypass, Aged, Aged, 80 and over, biology, business.industry, Mortality rate, Hemodynamics, General Medicine, Middle Aged, medicine.disease, Brain natriuretic peptide, Treatment Outcome, 10209 Clinic for Cardiology, biology.protein, Cardiology, Female, Creatine kinase, Cardiology and Cardiovascular Medicine, business, Switzerland, Follow-Up Studies, medicine.drug
Abstract

AIMS The aim of the present study was to analyze gender disparities in a large cohort of acute coronary syndrome (ACS) patients from the Zurich Acute Coronary Syndrome (Z-ACS) Registry. METHODS Gender disparities in ACS were examined. The primary endpoint included in-hospital death rate, and the secondary endpoint major adverse cardiac and cerebrovascular events (MACCEs) at 30-day follow-up. Furthermore, independent predictors for MACCEs and death were identified. RESULTS In total, 2612 patients with ACS were identified. Out of these, 23% were women. The mean age was higher in women (68.6 ± 12.2; P < 0.001). Troponin-T on admission (1.33 ± 4.64 vs. 1.19 ± 3.04 μg/l; P = 0.002) and N-terminal of the prohormone brain natriuretic peptide on admission (3456.2 ± 7286.7 vs. 1665.6 ± 4800.6 ng/l; P < 0.001) were higher in women compared with men. Single-vessel disease was more common in women (44.9 vs. 39.7%; P = 0.023) and, conversely, multivessel disease was more prevalent in male patients as compared with their female counterparts (59.4 vs. 54.4%; P = 0.029). At discharge, men were more likely prescribed statins (89.4 vs. 85.2%; P = 0.004). Overall mortality and MACCEs were similar for both genders. In women, peak creatine kinase and peak C-reactive protein emerged as independent predictors for MACCEs and SBP on admission, and maximal C-reactive protein and use of glycoprotein IIb/IIIa inhibitors (GPIIb/IIIa) as strong independent predictors for in-hospital death. CONCLUSION The present results suggest a closing gap in short-term outcome and improvement in cardiac care between women and men. Nonetheless, differences in treatment strategies continue to exist, particularly pertaining to statin regimens at discharge, which might potentially have a powerful impact on long-term outcomes and gender disparities.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results