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La presente investigación tuvo como objetivo general determinar la relación entre gestión administrativa y el desempeño laboral en la Universidad Nacional Jorge Basadre Grohmann en el 2020. El tipo de investigación es básica o pura, puesto que recoge información sin necesidad de posibles aplicaciones. Así mismo, el tipo de diseño fue no experimental y transversal, dado que no se manipulan ninguna de las variables. La muestra estuvo conformada por 208 servidores de la Universidad Nacional Jorge Basadre Grohmann, a quienes se les aplicaron cuestionarios estructurados en escala Likert. Entre los resultados más destacados, se obtuvo que el 34,6% se encuentra en un nivel Medio respecto a gestión administrativa, debido a que las dimensiones dirección y control son las que más afectan a la variable, lo que origina que, los objetivos que fueron planificados, no se cumplan satisfactoriamente. Por otro lado, el 38,5% se encuentra en un nivel Medio referente a desempeño laboral, puesto que las dimensiones capacidad y motivación son las que más afectan a la variable, lo que causa que su rendimiento no sea el más óptimo y no cumplan sus funciones de manera eficiente. Finalmente, como conclusión, se determinó que, mediante el coeficiente de correlación de Pearson, se obtuvo una correlación positiva muy fuerte entre gestión administrativa y desempeño laboral de 0,952 siendo significativa con un p

Liver cancer is one of the main causes of death related to cancer worldwide; its etiology is related with infections by C or B hepatitis virus, alcohol consumption, smoking, obesity, nonalcoholic fatty liver disease, diabetes, and iron overload, among other causes. Several kinds of primary liver cancer occur, but we will focus on hepatocellular carcinoma (HCC). Numerous cellular signaling pathways are implicated in hepatocarcinogenesis, including YAP-HIPPO, Wnt-β-catenin, and nuclear factor-κB (NF-κB); these in turn are considered novel therapeutic targets. In this review, the role of lipid metabolism regulated by peroxisome proliferator-activated receptor gamma (PPARγ) in the development of HCC will also be discussed. Moreover, recent evidence has been obtained regarding the participation of epigenetic changes such as acetylation and methylation of histones and DNA methylation in the development of HCC. In this review, we provide detailed and current information about these topics. Experimental models represent useful tools for studying the different stages of liver cancer and help to develop new pharmacologic treatments. Each model in vivo and in vitro has several characteristics and advantages to offer for the study of this disease. Finally, the main therapies approved for the treatment of HCC patients, first- and second-line therapies, are described in this review. We also describe a novel option, pirfenidone, which due to its pharmacological properties could be considered in the future as a therapeutic option for HCC treatment.

A novel formulation and training procedure for full Boltzmann machines in terms of a mixed binary quadratic feasibility problem is given. As a proof of concept, the theory is analytically and numerically tested on XOR patterns.

Additional file 1. Additional Figures S1, S2 and Tables S1–S6.

La epidemiología tiene una deuda histórica con la humanidad. En este contexto, urgen nuevos enfoques teóricos y epistémicos que desde la transdisciplinariedad y la complementariedad, aborden el complejo proceso salud-enfermedad, hasta ahora dominado por el hegemónico modelo biomédico, de la epidemiologia convencional, el cual ha gene rado importantes aportes a la humanidad. Sin embargo, las complejidades anuncian la necesidad de la reconfiguración c onceptual de la epidemiología convencional, hacia caminos emancipatorios, que generen el neo humanismo. Tejer o entretejer las disciplinas como posibilidad de una humanidad en completud, que permita vencer la limitación y fragmentación del sujeto de su contexto socio-cultural e histórico, que impide ver el problema en su plenitud y por ende construir las soluciones, es un desafío que debemos conquistar. La epidemiología critica, a través de la integración de los enfoques complementarios debe mantener una vigilancia epistemológica sobre los usos y límites de las técnicas respectivas a dicho enfoques, evitando la noción ahistórica y congelada de los fenómenos. Es ineludible realizar el análisis del proceso socio histórico bajo el enfoque de la determinación social, que permite ver más allá de los determinantes sociales, asociados a los clásicos factores de riesgo y estilos de vida individuales. Finalmente se plantea la necesidad de transitar desde un concepto más complejo, que integre la determinación social de la salud, con la ecología crítica, hacia la conquista del buen vivir. Solo así es posible subsanar las desigualdades sanitarias, transitando hacia la transformación y la emancipación del ser humano en complexus con la vida planetaria. Epidemiology has a historical debt to humanity. In this context, new theoretical and epistemological approaches from transdisciplinary and complementarity arises, to address the complex health-disease process, so far dominated by the hegemonic biomedical model of conventional epidemiology, which has generated significant contributions to humanity. However, the complexities announce the need for the conceptual reconfiguration from the conventional epidemiology to emancipatory paths that generate the neohumanism. Knitting or weaving disciplines as possibility of humanity in completeness, that allows overcome the limitation and fragmentation of the subject of their socio-cultural and historical context, which complicates the problem in its fullness, and thus, building solutions is a challenge we must conquer. Critical epidemiology, through the integration of complementary approaches must maintain an epistemological vigilance on the uses and limits of the respective approaches to such techniques, avoiding frozen ahistorical notion of phenomena. Performing the analysis of socio-historical process under the approach to social determination is an obligation, which allows seeing beyond the social determinants associated with c lassical risk factors and individual lifestyles. Finally, there is a need to move from a more complex concept, integrating the social determinants of health, with critical ecology, to the conquest of a good living. Health inequalities can fill the gaps in this way, moving towards transformation and emancipation of human beings in complexus with the planetary life.

PurposeThe Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc, Sylmar, CA) was developed to restore some vision to patients blind as a result of retinitis pigmentosa (RP) or outer retinal degeneration. A clinical trial was initiated in 2006 to study the long-term safety and efficacy of the Argus II System in patients with bare or no light perception resulting from end-stage RP.DesignProspective, multicenter, single-arm clinical trial. Within-patient controls included the nonimplanted fellow eye and patients' native residual vision compared with their vision with the Argus II.ParticipantsThirty participants in 10 centers in the United States and Europe.MethodsThe worse-seeing eye of blind patients was implanted with the Argus II. Patients wore glasses mounted with a small camera and a video processor that converted images into stimulation patterns sent to the electrode array on the retina.Main outcome measuresThe primary outcome measures were safety (the number, seriousness, and relatedness of adverse events) and visual function, as measured by 3 computer-based, objective tests. Secondary measures included functional vision performance on objectively scored real-world tasks.ResultsTwenty-four of 30 patients remained implanted with functioning Argus II Systems at 5 years after implantation. Only 1 additional serious adverse event was experienced after the 3-year time point. Patients performed significantly better with the Argus II on than off on all visual function tests and functional vision tasks.ConclusionsThe 5-year results of the Argus II trial support the long-term safety profile and benefit of the Argus II System for patients blind as a result of RP. The Argus II is the first and only retinal implant to have market approval in the European Economic Area, the United States, and Canada.

A partir del ciclo Escolar 2009-2010, lla Dirección General del Bachillerato, incorporó en su plan de estudios los principios básicos de la Reforma Integral de la Educación Media Superior, cuyo propósito es proporcionar una educación pertinente y relevante al estudiante. 1747