1. The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification
- Author
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Vrede, Stephanie W., Hulsman, Anneloes M.C., Reijnen, Casper, van de Vijver, Koen K.B.T., Colas, Eva, Mancebo Moreno, Gemma, Moiola, Cristian Pablo, Gil-Moreno, Antonio, Huvila, Jutta, Koskas, Martin, Weinberger, Vit, Minář, Luboš, Jandáková, Eva, Santacana, Maria, Matias-Guiu, Xavier, Amant, Frédéric, Snijders, Marc P.L.M., Küsters-Vandevelde, Heidi V.N., ENITEC-Consortium, Bulten, Johan Hans, Pijnenborg, Johanna M.A., Institut Català de la Salut, [Vrede SW] Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands. Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands. [Hulsman AMC] Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands. [Reijnen C] Department of Radiation Oncology, Radboud university medical center, Nijmegen, the Netherlands. [Van de Vijver K] Department of Pathology, Ghent University Hospital, Cancer Research Institute Ghent (CRIG), Ghent, Belgium. [Colas E, Moiola CP] Grup de Recerca Biomèdica en Ginecologia, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERONC, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Mancebo G] Department of Obstetrics and Gynaecology, Hosepital del Mar, PSMAR, Barcelona, Spain. [Gil-Moreno A] Servei de Ginecologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Servei d’Anatomia Patològica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. CIBERONC, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Amsterdam Reproduction & Development (AR&D), Obstetrics and Gynaecology, and CCA - Imaging and biomarkers
- Subjects
Endometri - Càncer - Cirurgia ,Cura preoperatòria ,Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Obstetrical and Gynecological::Hysteroscopy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Therapeutics::Patient Care::Preoperative Care [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Obstetrics and Gynecology ,Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms [DISEASES] ,Otros calificadores::Otros calificadores::/cirugía [Otros calificadores] ,Endometrial carcinoma ,Endometrial sampling ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Histeroscòpia ,Other subheadings::Other subheadings::/surgery [Other subheadings] ,All institutes and research themes of the Radboud University Medical Center ,diagnóstico::técnicas y procedimientos diagnósticos::técnicas diagnósticas obstétricas y ginecológicas::histeroscopia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Oncology ,terapéutica::asistencia al paciente::asistencia preoperatoria [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Diagnosis ,Pathology ,Concordant ,Discordant ,neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales [ENFERMEDADES] - Abstract
Diagnosis; Endometrial carcinoma; Endometrial sampling Diagnóstico; Carcinoma de endometrio; Muestreo endometrial Diagnòstic; Carcinoma endometrial; Mostreig endometrial Objective To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome. Methods A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1–2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC). Results The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm2 and 23.5 mm2 (P = 0.022). Sampling method did not influence the concordance in tumor classification. Patients with preoperative high-grade and postoperative low-grade showed significant lower DSS compared to patients with concordant low-grade EC (P = 0.039). Conclusion The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.
- Published
- 2022