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1. A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein–coupled receptors

Author

Pierre-Yves Jean-Charles, Vishwaesh Rajiv, Subhodeep Sarker, Sangoh Han, Yushi Bai, Ali Masoudi, and Sudha K. Shenoy

Subjects
Ubiquitin, Phenylalanine, Animals, Cattle, Cell Biology, beta-Arrestin 2, Molecular Biology, Biochemistry, Receptors, G-Protein-Coupled
Abstract

Arrestins and their yeast homologs, arrestin-related trafficking adaptors (ARTs), share a stretch of 29 amino acids called the ART motif. However, the functionality of that motif is unknown. We now report that deleting this motif prevents agonist-induced ubiquitination of β-arrestin2 (β-arr2) and blocks its association with activated G protein-coupled receptors (GPCRs). Within the ART motif, we have identified a conserved phenylalanine residue, Phe116, that is critical for the formation of β-arr2-GPCR complexes. β-arr2 Phe116Ala mutant has negligible effect on blunting β

Published
2022

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