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4. Additional file 4: of Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review

Author

Stuurman, Anke, Noordegraaf-Schouten, Marije Vonk, Kessel, Femke Van, Oordt-Speets, Anouk, Sandgren, Andreas, and Werf, Marieke Van Der

Subjects
bacterial infections and mycoses
Abstract

Study characteristics, outcomes, and risk of bias assessment of articles on interventions to improve initiation, adherence and completion of LTBI treatment regimens. (DOCX 104 kb)

Published
2016
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6. Additional file 3: of Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review

Author

Stuurman, Anke, Noordegraaf-Schouten, Marije Vonk, Kessel, Femke Van, Oordt-Speets, Anouk, Sandgren, Andreas, and Werf, Marieke Van Der

Subjects
bacterial infections and mycoses
Abstract

Study characteristics, outcomes, and quality aspects of risk of bias assessment of articles on determinants of initiation, adherence and completion of LTBI treatment regimens. (DOCX 151 kb)

Published
2016
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8. Additional file 3: of Initiation and completion rates for latent tuberculosis infection treatment: a systematic review

Author

Sandgren, Andreas, Noordegraaf-Schouten, Marije Vonk, Kessel, Femke Van, Stuurman, Anke, Oordt-Speets, Anouk, and Werf, Marieke Van Der

Subjects
bacterial infections and mycoses
Abstract

Study characteristics, outcomes, and quality aspects of risk of bias assessment of articles on initiation and completion rates of LTBI treatment regimens. (DOC 680Â kb)

Published
2016
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9. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

Author

Lange, Christoph, Abubakar, Ibrahim, Alffenaar, Jan-Willem C, Bothamley, Graham, Caminero, Jose A, Carvalho, Anna Cristina C, Chang, Kwok-Chiu, Codecasa, Luigi, Correia, Ana, Crudu, Valeriu, Davies, Peter, Dedicoat, Martin, Drobniewski, Francis, Duarte, Raquel, Ehlers, Cordula, Erkens, Connie, Goletti, Delia, Günther, Gunar, Ibraim, Elmira, Kampmann, Beate, Kuksa, Liga, de Lange, Wiel, van Leth, Frank, van Lunzen, Jan, Matteelli, Alberto, Menzies, Dick, Monedero, Ignacio, Richter, Elvira, Rüsch-Gerdes, Sabine, Sandgren, Andreas, Scardigli, Anna, Skrahina, Alena, Tortoli, Enrico, Volchenkov, Grigory, Wagner, Dirk, van der Werf, Marieke J, Williams, Bhanu, Yew, Wing-Wai, Zellweger, Jean-Pierre, Cirillo, Daniela Maria, and TBNET

Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.

Published
2014

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