31 results on '"Sameh Fayek GamalEl Din"'
Search Results
2. Serum nesfatin‐1 level in men with diabetes and erectile dysfunction correlates with generalized anxiety disorder‐7: A prospective comparative study
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Ahmed, Ragab, Mahmoud Hassan, Ahmed, Ahmed, Reda Sayed, Dalia Adel Kamal, EldinAbdelbary, and Sameh Fayek, GamalEl Din
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Endocrinology ,Reproductive Medicine ,Urology ,Endocrinology, Diabetes and Metabolism - Abstract
Current studies have suggested a close link between nesfatin-1, an appetite-related neuropeptide and gonadal hormones.We investigated the association between nesfatin-1 serum level and erectile dysfunction severity in men with diabetes as well as the generalized anxiety disorder-7 questionnaire, the patient health questionnaire-9, serum testosterone, kidney and liver functions, glycated haemoglobin and lipid profile.Seventy-five participants between 30 and 60 years were enrolled, 25 erectile dysfunction patients with type 2 diabetes (group I), 21 with diabetes and preserved erectile function (group II) and 29 healthy controls (group III). Erectile dysfunction status and severity were determined by the Arabic version of the international index of erectile function-5 for all the participants. Psychological wellbeing was checked by the generalized anxiety disorder-7 questionnaire and the patient health questionnaire-9. Finally, participants were evaluated for serum nesfatin-1, serum testosterone, kidney and liver functions, glycated haemoglobin and lipid profile.Serum nesfatin-1 levels were significantly lower in groups I and II compared to the controls. The international index of erectile function-5 scores had shown significant correlations with serum nesfatin-1, serum testosterone, generalized anxiety disorder-7, patient health questionnaire-9, diastolic blood pressure, glycated haemoglobin, triglycerides, creatinine and albumin/creatinine ratio. Receiver operating characteristic analysis revealed that serum nesfatin-1 ≥ 0.62 ng/ml, serum testosterone ≥2.9 ng/ml, generalized anxiety disorder-7 score ≥7.5, patient health questionnaire-9 score ≥5, glycated hemoglobin ≥6.4%, triglycerides ≥ 144 mg/dl, creatinine ≥ 0.85 mg/dl and albumin/creatinine ratio ≥ 26.5 are useful predictors of erectile dysfunction in men with type 2 diabetes, and the area under the curve for those variables was respectively 0.83, 0.76, 1, 0.75, 0.88, 0.72, 0.67 and 0.77. Finally, a linear regression analysis revealed that generalized anxiety disorder-7 was the only strong independent predictor of the international index of erectile function-5 (p 0.001).Nesfatin-1 can be used as a biomarker for the severity of anxiety in erectile dysfunction patients with diabetes. Use of this molecule in treatment of diabetes and erectile dysfunction should be strengthened by larger studies. Psychiatric care must be offered to patients with diabetes and erectile dysfunction and low serum nesfatin-1 as they experience intense anxiety and depression.
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- 2022
3. Evaluation of the Utility of Seminal Plasma Resistin and Leptin in Predicting Successful Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia
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Medhat Kamel Amer, Wael Zohdy, Sameh Fayek GamalEl Din, Hanan Hosni Moawad, Dina Atef Hasan El Saedy, Eman Ahmed Zaki Gamal, and Ahmed Ragab
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Reproductive Medicine - Abstract
Background: The purpose of the current study was evaluation of the utility of seminal plasma (SP) resistin and leptin in predicting successful surgical sperm retrieval (SSR) in men with non-obstructive azoospermia (NOA). Methods: This prospective comparative study was conducted in the andrology clinic of a specialized fertility center. In total, 53 NOA men as candidates for either first time micro‐testicular sperm extraction (micro-TESE) or repeat micro-TESE and 28 normozoospermic controls were included. ELISA was used for measurement of SP resistin and leptin levels in all participants. Significance level was defined as p< 0.05. Results: The current study demonstrated a significant positive correlation between estradiol (E2) level in serum and SP resistin (r=0.342, p=0.025). Also, there was a highly significant positive correlation between SP leptin and SP resistin (r=0.568, p= 0.001). Interestingly, SP leptin was the only variable that demonstrated a significant correlation with eventful micro-TESE outcome in men who underwent micro-TESE for the first time. Finally, ROC curve showed that SP leptin level of 4.05 ng/ml predicted successful SSR in men who underwent micro-TESE for the first time with a sensitivity of 73.3% and a specificity of 75% as 11 out of 27 (41%) cases showed eventful micro-TESE at or above this cut-off level [AUC of 0.747, 95% CI, lower bound of 0.555, and upper bound of 0.939, p=0.030]. Conclusion: SP leptin can be used as a non-invasive biomarker to predict successful SSR in NOA cases undergoing first time micro-TESE, while SP resistin failed to play the same role.
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- 2023
4. Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study
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Sameh Fayek GamalEl Din, Ashraf Zeidan, Mohamed Ahmed Abdel Salam, Noha Abd EL Hafeez Abd El Kader, Sara Ahmed Mohamed, and Mohamed Farag Azmy
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Obstetrics and Gynecology - Abstract
The present study compared seminal calbindin 2 (CALB 2) levels and semen parameters in men with and without varicocele. CALB 2 is also known as calretinin and 29 kDa calbindin. The study was a case-control study conducted from April (2021) to March (2022) in the andrology department at Beni-Suef University hospital. The study included four matched groups: group (I) were controls (fertile normozoospermic men without varicocele) (n=24). Group (II) were fertile normozoospermic men with varicocele (n=24). Group (III) were infertile oligoasthenoteratozoospermia (OAT) men without varicocele (n=24). Group (IV) were infertile OAT men with varicocele (n=24). The lowest levels of seminal CALB 2 were found in patients with severe oligozoospermia which showed a statistically significant difference when compared to seminal CALB 2 in patients with normal, mildly low, or moderately low sperm counts. There were significant negative correlations between sperm concentration, sperm motility and percentage of normal sperm forms and seminal CALB 2. Seminal plasma CALB 2 may play a role in the negative impact of varicocele on the semen parameters especially sperm concentration, sperm motility and percentage of sperm normal forms. Future studies are needed to verify these findings.
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- 2023
5. Study of the role of microRNAs 16 and 135a in patients with lifelong premature ejaculation receiving fluoxetine daily for 3 months: A prospective case control study
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Sameh Fayek GamalEl Din, Ahmad Tarek Motawi, Laila Ahmed Rashed, Hany Elghobary, Hany Mohammed Saad, Mohamed Mahmoud Ismail, and Hesham Fouad Abdel‐latif
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Male ,MicroRNAs ,Time Factors ,Endocrinology ,Case-Control Studies ,Fluoxetine ,Urology ,Humans ,Ejaculation ,General Medicine ,Premature Ejaculation - Abstract
We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls. Moreover, we evaluated the potential interplay between the studied miRNAs and fluoxetine in these patients after utilizing fluoxetine daily for 3 months. The study involved 60 consecutive LPE patients and 20 healthy age matched individuals as controls. The median miRNA16 was significantly higher in the controls (1.02) compared to the patients (0.31) (p 0.001). Moreover, the median miRNA-135a was significantly higher in the controls compared to the patients 1.02 and 0.35, p 0.001, respectively. In addition, the median pre-treatment miRNA16 in the responders was 0.29 that significantly increased to 0.66 (p 0.001). The median pre-treatment miRNA-135a in the responders was 0.27 that significantly increased to 0.65 (p 0.001). Furthermore, considering EXP(β) for the odds ratio evaluation, with a 95% degree of confidence, a 1 fold increase in pre-treatment miRNA 135a fold change decreases the odds for being responsive to SSRI by 0.028. Meanwhile, there was non-significant association between fluoxetine responsiveness and age, pre-treatment miRNA 16, pre-treatment PEDT and pre-treatment IELT. The current study had shown that a lower pre-treatment miRNA 135a was significantly associated with response to fluoxetine.
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- 2022
6. A cross-sectional study of the genital duct and renal anomalies in Egyptian cases of congenital absence of the vas deferens
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Sameh Fayek GamalEl Din, Mohamed Abd, Hatem El-Azizi, Yasser Ibrahem Elkhiat, Taha Abdelnaser, Ahmed Mahmoud Elshibany, and El Fatah
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Male ,medicine.medical_specialty ,Urology ,Absent vas deferens ,Physical examination ,urologic and male genital diseases ,Vas Deferens ,Prostate ,medicine ,Humans ,Sex organ ,Renal agenesis ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Congenital absence of the vas deferens ,Cross-Sectional Studies ,medicine.anatomical_structure ,Reproductive Medicine ,Agenesis ,Transrectal ultrasonography ,Egypt ,Kidney Diseases ,business - Abstract
The aim of the study was to detect the incidence and types of genital and renal duct anomalies associated with congenital absent vas deferens (CAVD). In 200 males with CAVD, the demographic characteristics, physical examination findings were evaluated. Scrotal ultrasonography and transrectal ultrasonography (TRUS) were used as the diagnostic methods for evaluating unilateral or bilateral CAVD with associated abnormalities or agenesis of the testes, epididymes, seminal vesicles and prostate. Abdominal ultrasound was performed to detect any associated renal anomalies. There were a total of 111 CBAVD and 89 CUAVD males. Eight cases (8.98%) of CUAVD were associated with contralateral cryptorchidism. In most cases there were agenesis in the epididymal body and tail and seminal vesicles. Different types of renal anomalies (32.50%) especially renal agenesis were observed mainly in cases of left CUAVD and were predominately on the left hand side. An important implication of our study is the importance of requesting ultrasound of males with CAVD to discover any associated anomalies especially renal agenesis that may be ignored by many physicians.
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- 2021
7. Evaluation of the potential role of shear wave elastography as a promising predictor of sperm retrieval in non‐obstructive azoospermic patients: A prospective study
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Omar Abdulsalam Mohammad Azzazi, Sameh Fayek GamalEl Din, Hatem El-Azizi, Alaaeldien Mohamed Abdelmoniem Abdelaal, and Mohamed Shokr Mohamed
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Adult ,Male ,medicine.medical_specialty ,Sperm Retrieval ,Urology ,Endocrinology, Diabetes and Metabolism ,Sonoelastography ,Semen ,Young Adult ,Endocrinology ,Predictive Value of Tests ,Region of interest ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Azoospermia ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,medicine.disease ,Testicular sperm extraction ,Semen Analysis ,Reproductive Medicine ,Elasticity Imaging Techniques ,Elastography ,Radiology ,business - Abstract
Background and objectives Testicular sperm extraction (TESE) has been a useful diagnostic and therapeutic tool with sperm retrieval opportunity varying according to the pathological finding in azoospermic patients. Sonoelastography (SE) is an exciting radiologic method that can measure relative elasticity of different tissues in a selected region of interest (ROI) by depending on fast cross-correlation technique and a combined autocorrelation method. Real-time elastography (RTE) can be used for structural analysis of testicular tissue to detect pathological tissue alterations. We aimed in the current study to evaluate the efficacy of shear wave elastography (SWE) in predicting sperm retrieval in non-obstructive azoospermic (NOA) patients undergoing TESE. Patients and methods This prospective study included 50 NOA patients who did two successive semen analyses with normal or elevated gonadotrophic hormones. All participants were subjected to SWE imaging on the testes by a radiologist. The measurements were recorded in terms of kPa using the SWE mode. They were done on each testis in the longest longitudinal plane. SWE images were viewed using dual mode: elasticity mode (kPa) and propagation (arrival time contour) mode then patients underwent TESE. Results A significant difference in SWE values was observed between patients with successful sperm retrieval and those with negative sperm retrieval providing 94.7% negative predictive value and 50.0% positive predictive value for sperm retrieval in NOA patients undergoing TESE with 75.0% sensitivity and 85.71% specificity (p = 0.0001). Mean stiffness index measured by SWE correlated significantly with the histopathological types as 8 patients only were diagnosed as having severe hypospermatogenesis. Discussion and conclusion These prime data suggest that SWE as a non-invasive, easily applicable, and repeatable imaging method has a promising potential to be one of the reliable sonographic modalities that can be used as one of the predictors for sperm retrieval in NOA patients.
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- 2021
8. Estimation of Serum and Seminal Plasma Levels of Glactin-1 in Non-Obstructive Azoospermia Cases and Their Correlations with the Rate of Sperm Retrieval: A Comparative Prospective Study
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Sameh Fayek GamalEl Din, Khadiga Abougabal, Hany Mohammed Saad, Mohamed Shokr Mohamed, Amira Mahmoud Mohamed Ali, and Ahmed Abo Sief
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Reproductive Medicine - Abstract
Background: Remarkably, the current study is one of the first to deploy galectin-1 (Gal-1) in determining the degree of impairment of spermatogenesis among cases with non-obstructive azoospermia (NOA) as well as utilizing it as a biomarker to predict the rate of sperm retrieval in these patients. The purpose of the study was to evaluate the seminal plasma and serum levels of Gal-1 in NOA patients as well as their correlations with Johnsen’s tubular biopsy scoring (JTBS). Methods: The current case control study included totally 48 patients with NOA whose ages ranged from 24 to 46 years old and 50 age matched healthy controls. Gal-1 levels were measured in both seminal plasma and serum of all subjects by the enzyme-linked immunosorbent assay (ELISA). Results: A significant negative correlation between seminal plasma levels of Gal-1 and JTBS was detected (r= -0.281, p=0.048) in the NOA cases. Interestingly, the receiver operating characteristic (ROC) curve had demonstrated that the cutoff value of seminal plasma levels of Gal-1 in determining azoospermia was >0.735 ng/ml and the area under the curve (AUC) was 0.858. The sensitivity, specificity, positive predictive, and negative predictive values for seminal plasma levels of Gal-1 were 76, 92, 90.5, and 79.3, respectively. In addition, sensitivity, specificity, positive predictive, and negative predictive values for serum levels of Gal-1 were 38, 66, 52.8, and 51.6, respectively. Conclusion: Seminal plasma levels of Gal-1 are higher in NOA men versus healthy controls. Interestingly, negative correlation of seminal plasma levels of Gal-1 with JTBS was determined. Thus, it can be used as a good predictor for NOA cases.
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- 2022
9. Evaluation of the sexual function of female partners of men with erectile dysfunction receiving different treatment modalities: An observational study
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Nashaat Nabil Ismail, Sameh Fayek GamalEl Din, Amr Abdel Raheem, Esraa Mohamed Rashad, and Mohamed Farag
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Male ,Sexual Partners ,Erectile Dysfunction ,Penile Erection ,Surveys and Questionnaires ,Humans ,Pain ,Female ,General Medicine ,Penile Prosthesis - Abstract
Objective: To evaluate sexual functions of patients with erectile dysfunction (ED) and their female partners. Methods: A total of 90 consecutive ED patients who received different ED therapies and their partners and 90 consecutive controls and their partners were divided into four groups. All participants were evaluated by the 15-item international index of erectile function and the Arabic version of female sexual function index (Ar-FSFI). Results: All ED patients who received sildenafil demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p 0.354). All ED patients who received quadmix demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in desire level (2.6 ± 0.67, 2.63 ± 0.85, p = 0.869) and lubrication maintenance (3.53 ± 0.82, 3.47 ± 0.82, p = 0.423). Finally, All ED patients who underwent semi rigid penile implant demonstrated significant improvements of their erectile function compared to baseline. Their female partners demonstrated significant improvements in all items of FSFI-19 compared to baseline except the frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p = 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p = 0.354). Conclusions: Sexual functions of ED males significantly improved after ED therapies. Nevertheless, some sexual functions of their partners were not positively impacted.
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- 2022
10. Intrasurgical Seminiferous Tubular Diameter Correlates with Total Motile Sperm Count in Azoospermia: a Prospective Cohort Study
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Medhat Amer, Sameh Fayek GamalEl Din, Ashraf Zeidan, Ahmed Adel, Islam Elsisi, Emad Fakhry, and Ahmed Raef Sadek
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Male ,Sperm Retrieval ,Sperm Count ,Testis ,Obstetrics and Gynecology ,Humans ,Prospective Studies ,Spermatozoa ,Azoospermia ,Retrospective Studies - Abstract
We aimed to find a correlation between the intraoperative diameters of the seminiferous tubules evaluated at high magnification during micro-testicular sperm extraction (micro-TESE) and total motile sperm count (TMSC) in non-obstructive azoospermic (NOA) patients. Five hundred four consecutive NOA patients were included and underwent micro-TESE. The change in the mean TMSC and different seminiferous tubular diameters was of high statistical significance (p p
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- 2022
11. Testing awareness of fertility and reproductive health among unmarried medical students at Cairo University
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Wael F. Saleh and Sameh Fayek GamalEl Din
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Male ,Health Knowledge, Attitudes, Practice ,Students, Medical ,Universities ,media_common.quotation_subject ,Fertility ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,Child ,Reproductive health ,media_common ,030219 obstetrics & reproductive medicine ,Fertility awareness ,business.industry ,Vasectomy ,Single Person ,General Medicine ,Reproductive Health ,Sexual dysfunction ,Mode of delivery ,Female ,medicine.symptom ,business ,Demography - Abstract
Aim: We aimed in this survey to assess fertility and reproductive health awareness among medical students. Methods: A total of 354 female and male final year medical students (193 females and 157 males) were recruited for this survey at the Kasr Al-Ainy Faculty of Medicine, who attended the lectures of the andrology and sexually transmitted disease department. Results: Our study demonstrated that the mean ages of the female and male medical students when they want to have their first child were 26.95 ± 2.924 and 28.7 ± 3.94, respectively, and and p = 0, while the mean ages of the female and male medical students when they want to have their last child were 32.5 ± 3.2 and 34.7 ± 5.1, respectively, and p = 0.001. Our study demonstrates that a majority of the female and male medical students moderately estimated the efficacy of the assisted reproductive technique to take a baby home, and the means of their estimation were 42.620% ± 12% and 43.5% ± 13.1% and p = 0.482. Moreover, our study showed that 75 (39.1%) females were convinced that vaginal delivery has a potential negative effect on the sexual functions. However, 99 (51.6%) females did not see any potential negative effect of vaginal delivery. In addition, 18 (9.4%) females responded in an indefinite way to this question. Finally, our study demonstrated that 145 (92.4%) males rejected the proposal of vasectomy. Conclusions: Interestingly, our study revealed increased estimation by the participants of the efficacy of the assisted reproductive technique to take a baby home, despite the fact that they were medical students who had already studied the subject of gynecology in their fifth year and should have estimated it properly.
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- 2020
12. Evaluation of neoadjuvant gonadotropin administration with downregulation by testosterone prior to second time microsurgical testicular sperm extraction: A prospective case–control study
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Sameh Fayek GamalEl Din, Hossam El Din Hosni Ahmed, Medhat Amer, Ahmed Ragab Ahmed, and Ahmed Fawzy Megawer
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Adult ,Male ,Non obstructive azoospermia ,Microsurgery ,endocrine system ,medicine.medical_specialty ,Sperm Retrieval ,medicine.drug_class ,030232 urology & nephrology ,Urology ,Down-Regulation ,Chorionic Gonadotropin ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Humans ,Medicine ,Testosterone ,Prospective Studies ,Prospective cohort study ,Azoospermia ,030219 obstetrics & reproductive medicine ,urogenital system ,business.industry ,Case-control study ,Dihydrotestosterone ,Testosterone (patch) ,General Medicine ,Neoadjuvant Therapy ,Testicular sperm extraction ,Case-Control Studies ,Reproductive Control Agents ,Gonadotropin ,business - Abstract
Purpose: The aim of this prospective study was to determine whether there is a beneficial role of combining gonadotropin administration with testosterone downregulation in non-obstructive azoospermia patients prior to a second time microsurgical testicular sperm extraction after a negative one. Methods: A total of 40 non-obstructive azoospermia men were recruited from a specialized IVF center from 2014 to 2016. Participants were divided equally into two groups: Group A was subjected to testosterone downregulation alone for 1 month and then combined with gonadotropin administration for 3 months prior to second time testicular sperm extraction; Group B (controls) underwent second time microsurgical testicular sperm extraction without prior hormonal therapy. Results: Mean baseline follicle-stimulating hormone levels of the controls and the cases were 26.9 ± 11.8 and 25.4 ± 8.7, respectively. One month after testosterone downregulation, follicle-stimulating hormone level of the cases was normalized and became 2.4 ± 1.2. There was no statistically significant difference between baseline follicle-stimulating hormone levels of the controls and cases (p = 0.946). Remarkably, two cases were positive after downregulation (10%) and no controls were positive at second testicular sperm extraction (0%). There was no statistically significant difference between sperm retrieval after the second microsurgical testicular sperm extraction in the controls and the cases (p = 0.072). Conclusion: Patients who underwent first time testicular sperm extraction with unfavorable outcome due to different techniques may benefit from testosterone downregulation combined with neoadjuvant gonadotropin administration as it had shown positive sperms retrieval in 2 out of the 20 cases, especially those with hypergonadotropic azoospermia.
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- 2020
13. Easiness of sperms retrieval in non-obstructive azoospermia is a strong predictor of clinical pregnancy after intracytoplasmic sperm injection
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Wael Zohdy, Ahmed Sadek, Ahmed Ragab, Medhat Amer, Ahmed Abd El Baseer, and Sameh Fayek GamalEl Din
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Gynecology ,Azoospermia ,endocrine system ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,urogenital system ,business.industry ,medicine.medical_treatment ,Odds ratio ,medicine.disease ,Sperm ,Intracytoplasmic sperm injection ,Confidence interval ,Testicular sperm extraction ,03 medical and health sciences ,Follicle-stimulating hormone ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Sperm Retrieval ,medicine ,business ,reproductive and urinary physiology - Abstract
Background: Testicular sperm extraction followed by Intracytoplasmic Sperm Injection (TESE-ICSI) is the only route to genetically father a child in couples with Non-Obstructive Azoospermia (NOA).Objective: The aim was to identify the effect of severity of NOA on clinical pregnancy following ICSI.Patients and Methods: This retrospective study included 643 patients who underwent 712 ICSI cycles at a specialized In-Vitro Fertilization center between 2014 and 2019. We classified the patients into easy (445) and difficult NOA (267) based on the difficulty of microdissection TESE procedure, number of sperm retrieved, and the number of surgical attempts.Results: The clinical pregnancy rate is significantly higher in the easy NOA group [167/299 (55.8%)] as compared with the difficult NOA group [68/194 (35.1%)]. The mean age of the females and the mean follicle stimulating hormone (FSH) levels were significantly lower in the easy NOA group compared with the difficult group [27.5±4.3 vs 29.9±4.6 years, P=0.0001, and 6.8±2.1 vs 7.4±2.5 mIU/ml, P=0.004, respectively]. There were no significant differences between the 2 groups regarding the mean male age, FSH level, and testicular size. The cumulus mass and the number of mature oocytes injected correlated significantly with the clinical pregnancy (r=0.122, P=0.012 and r=0.145, P=0.003, respectively). The sperm source whether fresh or frozen, the testicular pathology, and the identification of round spermatids in the pathology specimens did not correlate with the clinical pregnancy. We used the binary logistic regression to identify the final predictors. Only the NOA severity could be used to predict ICSI outcome. Easy NOA is more likely to have positive outcomes with ICSI (Odds ratio=1.70; Confidence interval=1.069–2.71; P=0.025). The model showed that neither female age nor FSH level could predict ICSI outcome in those patients.Conclusion: Easy sperm retrieval is an independent factor that is associated with positive ICSI outcomes in couples with NOA.
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- 2020
14. Predictive factors of erectile dysfunction in Egyptian individuals after contracting COVID‐19: A prospective case–control study
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Osama Mohamed Elbokl, Hany Mohammed Saad, Ahmed Adel, and Sameh Fayek GamalEl Din
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Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,erectile dysfunction ,Urology ,smoking ,Endocrinology ,Hamilton depression rating scale ,Rating scale ,COVID‐19 ,Internal medicine ,international index of erectile function‐5 ,Medicine ,Humans ,Depression (differential diagnoses) ,business.industry ,SARS-CoV-2 ,Significant difference ,Case-control study ,COVID-19 ,General Medicine ,Original Articles ,medicine.disease ,Testosterone level ,Erectile dysfunction ,Case-Control Studies ,Anxiety ,Original Article ,Egypt ,medicine.symptom ,business - Abstract
This study aimed to screen healthy individuals who contracted COVID‐19 for erectile dysfunction (ED) and to determine the potential risk factors that can predict ED in these individuals. One hundred and seven cases versus 90 controls agreed to participate in the study. Two structured interviews with 1 month interval were conducted. All participants were evaluated by the validated Arabic version of the international index of erectile function (IIEF‐5) and assessment of the psychological state by Hamilton depression rating scale (HDRS). Interestingly, the study had demonstrated a significant difference in mean testosterone level between cases and controls (3.91 ± 2.31, 5.04 ± 2.22, p
- Published
- 2021
15. Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet-rich plasma in patients with erectile dysfunction: A prospective pilot study
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Hany Mohammed Saad, Hossam Refaat Eldebs, Shady Zaki Said, Ahmed Said Zaghloul, Abd El Rahman Mahmoud ElNashar, Ihab Abdel Latif Osman, and Sameh Fayek GamalEl Din
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Male ,medicine.medical_specialty ,Urology ,Hemodynamics ,Pilot Projects ,Endocrinology ,Erectile Dysfunction ,Internal medicine ,Medicine ,Humans ,In patient ,Multiple logistic regression analysis ,Prospective Studies ,business.industry ,Platelet-Rich Plasma ,Penile Erection ,Significant difference ,Smoking ,General Medicine ,Erectile function ,medicine.disease ,nervous system diseases ,Erectile dysfunction ,Platelet-rich plasma ,Quality of Life ,Smoking status ,business - Abstract
Erectile dysfunction (ED) is a common condition with a significant impact on the quality of life. Regenerative medicine maladies are intended to repair or replace damaged tissues and organs through different therapeutic mechanisms. Our aim was to study the effect of intra-corporeal injection (ICI) of platelet-rich plasma (PRP) in ED patients. Thirty-four patients' erectile function was evaluated by filling up an abridged form of the international index of erectile function (IIEF-5) before and after PRP therapy. ICI of PRP was done once per week for 2 months. All patients were prescribed PDE5Is for one month after PRP therapy. Penile haemodynamics was assessed using 20 µg of PGE1 before and 3 months after initiating PRP therapy. Interestingly, our study had shown that there was a statistically significant difference in the IIEF-5 score after ICI of PRP (-5.5, ±5.2, p=
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- 2021
16. Factors determining the sperm retrieval rate in fresh versus salvage micro-TESE: a comparative cohort study
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Sameh Fayek GamalEl Din, Medhat Amer, Ahmed Ragab Ahmed, and Asmaa Ahmed Abdel Hamid
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Adult ,Male ,Infertility ,Nephrology ,endocrine system ,medicine.medical_specialty ,Sperm Retrieval ,Urology ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Sertoli cell-only syndrome ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Testis ,Varicocele ,medicine ,Humans ,Infertility, Male ,Azoospermia ,Retrospective Studies ,Salvage Therapy ,business.industry ,Micro tese ,Age Factors ,Organ Size ,Middle Aged ,medicine.disease ,Hormones ,Hormonal therapy ,Histopathology ,Follicle Stimulating Hormone ,business ,Cohort study - Abstract
We studied prospectively the role of FSH, testis volume, age, duration of infertility, hormonal therapy, varicocelectomy and testicular histopathology in determining the sperm retrieval rate (SRR) in fresh versus salvage micro-TESE. Our study analysed retrospectively the prospectively maintained database of 330 NOA patients who underwent micro-TESE either 1st or 2nd or 3rd timers from January 2017 to August 2018 from the Andrology Clinic of a specialized IVF centre. They were divided equally into 3 groups, group (1) were 1st timers, group (2) were 2nd timers and group (3) were 3rd timers, respectively. Interestingly, our study demonstrated a positive correlation between high FSH level and favourable micro-TESE outcome in 1st timers who underwent micro-TESE (p 0.015). Additionally, our study revealed a positive correlation between age and favourable micro-TESE outcome in 2nd timers who underwent micro-TESE (p 0.031). Further, our study revealed a positive correlation between right testicular volume and favourable micro-TESE outcome in 1st timers who underwent micro-TESE (p 0.023). Eventually, there was a significant positive correlation between histopathology which was mainly sertoli cell only syndrome and favourable micro-TESE outcome in 1st timers micro-TESE (p 0.001). Our study demonstrates that sperms can be retrieved despite high FSH level, and preoperative histopathology is not essential in predicting SRR in NOA patients. Further, age can be considered a good prognostic factor in patients who undergo salvage micro-TESE for the 2nd time.
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- 2019
17. Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case–control study
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Mohamed E Amer, Mamdouh Hassan, Sameh Fayek GamalEl Din, and Attia Abd‐Allah Attia
- Subjects
Adult ,Male ,Nephrology ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Folic Acid Deficiency ,030204 cardiovascular system & hematology ,Logistic regression ,Severity of Illness Index ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Erectile Dysfunction ,Risk Factors ,Statistical significance ,Internal medicine ,Diabetes Mellitus ,medicine ,Humans ,Testosterone ,Risk factor ,Correlation of Data ,Prospective cohort study ,Ultrasonography, Doppler, Duplex ,business.industry ,Smoking ,Confounding ,Age Factors ,Case-control study ,Middle Aged ,medicine.disease ,Cholesterol ,Erectile dysfunction ,Hypertension ,Egypt ,business - Abstract
The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED. Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie’s disease, or decompensated systemic illnesses. ED was evaluated by the validated Arabic version of the abbreviated five-item form of the International Index Of Erectile Function and confirmed by penile duplex. Serum FA level was assayed using ELIZA. Mann–Whitney, Kruskal–Wallis, and Chi-square tests and Spearman correlation were used as appropriate and confirmed by logistic regression model. Our study revealed that the median FA of the cases and the controls were 7.1 ng/mL and 13.4 ng/mL, respectively, and this difference was of high statistical significance (p
- Published
- 2018
18. Study of the risk factors of erectile dysfunction and phospho diestrase type 5 inhibitors usage among Egyptian population with erectile dysfunction: A cross-sectional survey
- Author
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Ihab Kamel, Alaaeldien Mohamed Abdelmoniem Abdelaal, Taha Abd Elnaser Mohamed, Sameh Fayek GamalEl Din, and Ahmad Foad Mohammad
- Subjects
Adult ,Male ,Medical consultation ,medicine.medical_specialty ,Cross-sectional study ,Urology ,Population ,Myocardial Ischemia ,030232 urology & nephrology ,Hyperlipidemias ,Self Medication ,03 medical and health sciences ,0302 clinical medicine ,Erectile Dysfunction ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Prevalence ,medicine ,Chi-square test ,Humans ,education ,education.field_of_study ,030219 obstetrics & reproductive medicine ,business.industry ,Penile Erection ,Phosphodiesterase 5 Inhibitors ,medicine.disease ,Cross-Sectional Studies ,Erectile dysfunction ,Reproductive Medicine ,Concomitant ,Hypertension ,Egypt ,Ischaemic heart disease ,business - Abstract
We aimed to study the risk factors of erectile dysfunction (ED) and different patterns of phosphodiestrase type 5 inhibitors (PDE5is) usage among Egyptian patients.One thousand five hundred consecutive Egyptian patients complaining of ED were included in this cross-sectional study from July (2014) to October (2015). Patients were requested to answer the international index of erectile function questionnaire (IIEF-5). Statistical differences between groups were tested using Chi square test and Spearman's rho correlation coefficient for qualitative variables.Remarkably, significant associations between IIEF scores and aging and diabetes mellitus (DM) and hypertension (HTN) and ischaemic heart disease (IHD) and hyperlipidaemia were shown in the studied patients (p.0001, p.0001, p.0001, p.0001, p.0001, respectively). Eventually, our study showed significant correlations between different age groups and morning erection and lower urinary tract symptoms and HTN and IHD and DM where the severity of ED was directly proportional to the absence or decreased strength of morning erection with aging and the increased incidence of LUTS and HTN and IHD and DM with aging (p.0001; p=.001; p.0001; p.0001; p.0001, respectively).Our study demonstrated that aging; DM, HTN and hyperlipidaemia are potential major risk factors of ED in Egypt for further validation. In addition, most of the participants used PDE5is without prior medical consultation together with concomitant administration of illicit drugs.
- Published
- 2021
19. Drug-naïve Egyptian females with migraine are more prone to sexual dysfunction than those with tension-type headache: a cross-sectional comparative study
- Author
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Hossam El Din Hosni Ahmed, Mohammed I. Oraby, Sameh Fayek GamalEl Din, Ahmed Ragab Ahmed, and Heba Mohammad Abd Elhameed
- Subjects
Adult ,medicine.medical_specialty ,Visual analogue scale ,Migraine Disorders ,Anxiety ,Hospital Anxiety and Depression Scale ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Surveys and Questionnaires ,medicine ,Outpatient clinic ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,business.industry ,Depression ,Tension-Type Headache ,General Medicine ,medicine.disease ,Drug-naïve ,Sexual Dysfunction, Physiological ,Sexual dysfunction ,Cross-Sectional Studies ,Migraine ,Pharmaceutical Preparations ,Egypt ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Headache is one of the chronic disorders that can trigger sexual dysfunction due to complex mechanisms. This study recruited 120 consecutive patients from our outpatient clinics with migraine (n = 60), TTH (n = 60) as well as healthy age-matched controls (n = 60) for a total of 180 patients. All the participants were evaluated by the Arabic version of the female sexual function index (ArFSFI: 19 items), the abridged 5-item version of the international index of erectile function (IIEF-5), hospital anxiety and depression scale (HADS: 14 items), visual analog scale (VAS) score, and the headache impact test questionnaire (HIT-6TM: 6 items). A significant correlation was noticed between scores of total ArFSFI in women with TTH and their partners’ IIEF-5 scores (r = 0.773, p
- Published
- 2020
20. Effect of cryoprotectant-free vitrification versus conventional freezing on human testicular sperm motility: a prospective comparative study
- Author
-
Sameh Fayek GamalEl Din, El-Zahraa Rashad, Nashaat Nabil Ismail, Emad Fakhry, Ahmed Ragab, Medhat Amer, and Walaa Abd El Hakim
- Subjects
Male ,endocrine system ,Cryoprotectant ,100 spermatozoa ,030209 endocrinology & metabolism ,Cryopreservation ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Freezing ,medicine ,Humans ,Vitrification ,Prospective Studies ,Sperm motility ,Azoospermia ,030219 obstetrics & reproductive medicine ,urogenital system ,Chemistry ,Significant difference ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Sperm ,Spermatozoa ,Reproductive Medicine ,Sperm Motility ,Semen Preservation - Abstract
This study aimed to demonstrate the effect of conventional freezing versus cryoprotectant-free vitrification on the recovery of testicular sperm motility. Testicular samples were obtained from 50 patients with azoospermia for testicular biopsy ± potential sperm storage. We retrieved 100 spermatozoa from each patient divided equally into two straws. They were frozen using conventional freezing as a control group and cryoprotectant-free vitrification in micro-capillary system using open-pulled straws. Seven days later, cryopreserved straws were thawed and assessed in duplicate. The mean sperm motility between the original spermatozoa sample and the post warming sample was reduced after conventional freezing compared to cryoprotectant-free vitrification (4.48 ± 2.09% versus 3.25 ± 1.92%, p < 0.001; 4.48 ± 2.09% vs 3.68 ± 1.93%, p < 0.001, respectively). There was a significant difference between the two methods regarding the mean sperm motility after warming (3.38 ± 1.86% versus 3.76 ± 1.88%, p = 0.015). The mean recovery percent of testicular sperm motility from the original sperm sample was lower (p = 0.02) after conventional freezing compared to cryoprotectant-free vitrification (78.4 ± 28.17% versus 85.37 ± 23.63%). Overall, the rate of post-thaw recovery of human testicular sperm motility improved using cryoprotectant-free vitrification compared to conventional freezing.
- Published
- 2019
21. Sexual Functions in Male and Female Patients With Bipolar Disorder During Remission
- Author
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Mohamed A. Khalil, Yasser I. Elkhiat, Ahmed Fathy Abo Seif, Sameh Fayek GamalEl Din, and Nahla Saad Hassan
- Subjects
Adult ,Male ,Bipolar Disorder ,Sexual Behavior ,Urology ,Endocrinology, Diabetes and Metabolism ,Pain ,Personal Satisfaction ,Young Mania Rating Scale ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Endocrinology ,Quality of life ,Rating scale ,mental disorders ,Female patient ,Humans ,Medicine ,030212 general & internal medicine ,Bipolar disorder ,Depression (differential diagnoses) ,Depression ,business.industry ,Penile Erection ,medicine.disease ,030227 psychiatry ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Sexual Partners ,Mood ,Reproductive Medicine ,Quality of Life ,Female ,Sexual function ,business ,Clinical psychology - Abstract
Introduction Bipolar disorder is an episodic mood disorder that causes unusual shifts in mood and affects the ability to carry out day-to-day tasks. Aim Evaluation of the sexual function in men and women with bipolar disorder during remission. Methods 60 men and women with bipolar disorder and 60 age-matched control subjects were included. A Structured Clinical Interview of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition was performed to confirm the diagnosis, and Hamilton Depression Rating Scale (HAM-D) to assess the depressive symptoms and Young Mania Rating Scale (YMRS) to assess the manic symptoms. We assessed sexual function in both sexes using international indices of erectile function for men and sexual function of women. Main Outcome Measures Scores of HAM-D, YMRS, Arabic versions of International Index of Erectile Function (IIEF) and female sexual function (FSFI). Results Depressive symptoms showed insignificant adverse correlation with the IIEF in men, whereas they revealed adverse significant correlations with the items of female sexual function index (FSFI) except pain (correlation coefficients [r] = 0.349 [P = .059], r = 0.680 [P < .001], r = 0.574 [P = .001], r = 0.517 [P = .003], r = 0.569 [P = .001], r = 0.532 [P = .002], r = 0.609 [P < .001], r = 0.342 [P = .065], respectively). Interestingly, the manic symptoms were associated with sexual hyperfunctioning in the men and were insignificantly correlated with the different items of FSFI in the women (r = 0.414 [P = .023], r = 0.043 [P = .821], r = 0.100 [P = .601], r = 0.108 [P = .571], r = 0.183 [P = .332), r = 0.086 [P = .651], r = 0.022 (P = .907), r = 0.109 [P = .565], respectively). There was a positive correlation between the affected women’s satisfaction and their partners’ score (r = 0.374, P =.042). Finally, the mean score of pain was statistically higher in the female cases than the normal ones (mean ± SD = 3.6 ± 0.4, 3.4, ± 0.6; P = .036). Clinical implications A different approach may be mandatory for manic female patients. Strengths & Limitations This study is one of the few studies that evaluated the sexual function in patients with bipolar disorder especially during remission. Some limitations of this study must be mentioned. We failed to evaluate the female partners of the diseased males. Quality of life of the recruited patients was not assessed. Finally, the study included patients who were not drug free. Conclusion Manic symptoms in female bipolar I patients are associated with sexual hypofunctioning.
- Published
- 2018
22. Association between testicular microlithiasis and varicocele in infertile men: A comparative study
- Author
-
Sameh Fayek GamalEl Din, Mohamed Farid, Ahmed Sayed Abdel Baset, and Ahmed Ragab
- Subjects
Infertility ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Varicocele ,030232 urology & nephrology ,Urology ,Physical examination ,Semen analysis ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Color doppler ultrasonography ,Medical history ,business ,Testicular microlithiasis ,Subclinical infection - Abstract
patients with varicocele.Patients and Methods: A total of 60 patients with infertility and clinical varicocele were assessed in comparison with 60 healthy fertile controls. The two groups were evaluated by history taking, clinical examination as well as semen analysis (WHO, 2010). Color Doppler ultrasonography was performed to assess the rate of TM in both groups. Finally, hormonal profile was studied for those with infertility and sperm concentration less than 10 million/ml.Results: Sonographic features of TM were revealed in 4/ 60 (6.7%) of cases with varicocele. However, this finding was of statistical insignificance (P=0.081). Of those cases, three had left varicocele associated with ipsilateral TM and one had bilateral varicocele and bilateral TM, whereas there was no sonographic evidence of TM in controls. Cases with TM were associated with primary infertility. Conclusion: In brief, this study demonstrated that only four of the 60 patients revealed intratesticular calcifications, and this was statistically insignificant. Moreover, there were also 23 healthy controls with subclinical varicoceles that were detected by scrotal duplex. However, TM was not detected in them. Thus, association of TM with varicocele is controversial. Finally, we recommend further studies to replicate this finding and to perform studies that compare fertile men and infertile patients with varicoceles to replicate this finding.
- Published
- 2018
23. Pelvic chondro-sarcoma and erectile dysfunction: A challenging surgical case
- Author
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Sameh Fayek GamalEl Din, Mohamed Abd El Fatah, Emad Awny Fawzy, Ahmed Fathy Abo Sief, and Wessam Gamal Abo Senna
- Subjects
Male ,medicine.medical_specialty ,Sling (implant) ,business.industry ,Urology ,Chondrosarcoma ,Bone Neoplasms ,Middle Aged ,Lateral side ,medicine.disease ,Past history ,Surgery ,Left hemiscrotum ,03 medical and health sciences ,0302 clinical medicine ,Erectile dysfunction ,Erectile Dysfunction ,Reproductive Medicine ,030220 oncology & carcinogenesis ,Humans ,Medicine ,030211 gastroenterology & hepatology ,Sarcoma ,Pelvic Bones ,business - Abstract
A 46 year-old male presented suffering from refractory erectile dysfunction. The patient had a past history of pelvic chondro-sarcoma. This case was a challenge for us; the surgery performed for excision of the sarcoma has resulted in the elimination of both pubic ramia together with excision of part of both corpora and left hemiscrotum. The procedure included a sling application on one side with a mesh sock wrapped around the rear part of the extendor cylinder. Another sling was applied on the contra lateral side without a mesh sock.
- Published
- 2018
24. Role of Tribulus terrestris in Male Infertility: Is It Real or Fiction?
- Author
-
Sameh Fayek GamalEl Din
- Subjects
Male ,0301 basic medicine ,Infertility ,Tribulus terrestris ,Plants, Medicinal ,030219 obstetrics & reproductive medicine ,Nutrition and Dietetics ,Unprotected Sexual Intercourse ,Traditional medicine ,Plant Extracts ,business.industry ,medicine.disease ,complex mixtures ,Male infertility ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Tribulus ,Humans ,Medicine ,Pharmacology (medical) ,business ,Infertility, Male ,Phytotherapy ,Food Science - Abstract
Tribulus terrestris is an annual herb of the Zygophyllaceae family and is commonly known as Gokshur, Gokharu, or puncturevine. Flavonoids, alkaloids, saponins, lignin, amides, and glycosides are the main active phytoconstituents of this plant. Infertility is defined by the failure to conceive a child after one year or more of regular unprotected sexual intercourse. Infertility affects society at large and has a negative impact on the social and emotional aspects of the patient. This in-depth review presents several studies that evaluate the role of Tribulus terrestris in a chronological order to help us better understand the exact mechanism by which this herbal medicine acts in male infertility. In conclusion, the exact role of Tribulus terrestris in male infertility is still controversial and needs future double-blind placebo-controlled studies that deploy larger cohorts.
- Published
- 2017
25. Are the Cavernous Tissue and Serum Levels of Micro RNAs 200a and 206 Elevated in Patients With Refractory Veno-occlusive Erectile Dysfunction? A Comparative Study
- Author
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Lamiaa Tarek Tawfik, Hany Ahmed Fouad Alghobary, Sameh Fayek GamalEl Din, Mohammed S. ElSheemy, and Laila A. Rashed
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Nitric Oxide ,Real-Time Polymerase Chain Reaction ,Nitric oxide ,Impotence, Vasculogenic ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Refractory ,medicine ,Humans ,Blood test ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Penile Erection ,Penile implant ,Ultrasonography, Doppler ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Pathophysiology ,MicroRNAs ,030104 developmental biology ,Erectile dysfunction ,medicine.anatomical_structure ,Gene Expression Regulation ,ROC Curve ,chemistry ,Cavernous tissue ,RNA ,business ,Biomarkers ,Follow-Up Studies ,Penis - Abstract
OBJECTIVE To evaluate the association between miRNAs and veno-occlusive erectile dysfunction. Recently, this association between miRNAs and erectile dysfunction was extensively studied using animal models. Our aim was to explore the miRNAs expressions and functions in the development of erectile dysfunction, especially veno-occlusive dysfunction, using a human tissue. PATIENTS AND METHODS We prospectively recruited 60 patients with erectile dysfunction and controls between July 2015 and July 2016. The 30 patients had refractory veno-occlusive erectile dysfunction that was proven by investigations. They were scheduled for penile implant. The 30 controls were scheduled for repair of their fracture. We measured miRNAs (200a and 206) and nitric oxide in cavernous tissue and serum of both patients with erectile dysfunction and controls. RESULTS A significant association was found between the 2 mentioned miRNAs and erectile dysfunction (P
- Published
- 2017
26. Study of the Role of Body Mass Index and Serum Leptin as Potential Risk Factors in Patients with Lifelong Premature Ejaculation
- Author
-
Mohamed Abd El Mawgood, Sameh Fayek GamalEl Din, Mohamed Aref, Ahmed Ismael Mohamed Ismael Khattab, and Tarek Mohamed Tawfik
- Subjects
Future studies ,Potential risk ,Ejaculation ,business.industry ,Serum leptin ,Premature ejaculation ,medicine ,Physiology ,In patient ,Latency (engineering) ,medicine.symptom ,business ,Body mass index - Abstract
Introduction: several studies demonstrated the potential role of serum leptin in patients with premature ejaculation.Aim: we aimed in this study to evaluate the correlation between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation and healthy controls.Patients and Methods: this study was carried out on 80 consecutive patients and controls. Body mass index was measured in the patients and the controls. Serum leptin was measured in both groups at the end of the study. Additionally, the patients and the controls were asked to measure intra vaginal ejaculation latency time (IELT) by stop watch handled by their wives for 2 successive months.Results: our prospective analysis revealed a highly significant association between body mass index and serum leptin and intra-vaginal ejaculation latency time among the cases (p-value < 0.001, Discussion: the current study demonstrated a statistically significant association between BMI and serum leptin and IELT in the patients with lifelong premature ejaculation. Additionally, the results revealed a statistically significant association between BMI and IELT in the controls without any association with the serum leptin.Conclusion: the current study highlights the role of both body mass index and serum leptin as potential risk factors in patients with lifelong premature ejaculation. Eventually, future studies are required to duplicate this interesting association between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation.
- Published
- 2017
27. Sexual functions of females married to males with semi-rigid penile implant: A cross-sectional study
- Author
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Sameh Fayek GamalEl Din, Raghda Yehia Khalil, Mohamed Abd El Fattah Farag, Ahmed Ateyah Awwad, and Ahmed Fathy Abo Seif
- Subjects
Adult ,Male ,Cross-sectional study ,medicine.medical_treatment ,030232 urology & nephrology ,Dentistry ,Pilot Projects ,Prosthesis Design ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orgasm ,Spouses ,Aged ,030219 obstetrics & reproductive medicine ,business.industry ,Penile implant ,Penile prosthesis ,General Medicine ,Middle Aged ,medicine.disease ,Erectile dysfunction ,Cross-Sectional Studies ,Female ,Penile Prosthesis ,business ,Sexual function - Abstract
Erectile dysfunction is a highly prevalent disorder. It is estimated that more than 50% of men who ranged in age from 40 to 70 years old suffer from erectile dysfunction to some degree. We aimed in this pilot cross-sectional study to determine female sexual function and social satisfaction before and 6 months after penile prosthesis implant. This study was carried on 50 consecutive married women whose husbands underwent malleable penile prosthesis implant in our department from July 2015 to July 2016. Our results showed significant increase in desire, lubrication, orgasm, and satisfaction scores after 6 months of penile prosthesis operation compared to scores before penile prosthesis implant (p
- Published
- 2019
28. Study of the prevalence and patterns of phosphodiesterase type 5 inhibitor use among sexually active Egyptian males: A National Cross-sectional Survey
- Author
-
Ahmad Kamel Seddeik Abdel-Hameed, Sameh Fayek GamalEl Din, Hassan Mamdouh, Attia Abd‐Allah Attia, Mohamed E Amer, and Hossam El‐Din Gaber Mohamed El‐Moslemany
- Subjects
Adult ,Male ,Pleasure ,medicine.medical_specialty ,Sildenafil ,Cross-sectional study ,Urology ,030232 urology & nephrology ,Pharmacist ,Sildenafil Citrate ,03 medical and health sciences ,chemistry.chemical_compound ,Sexually active ,0302 clinical medicine ,Endocrinology ,Erectile Dysfunction ,Surveys and Questionnaires ,medicine ,Prevalence ,Male population ,Humans ,030219 obstetrics & reproductive medicine ,business.industry ,Penile Erection ,Coitus ,General Medicine ,Erectile function ,Middle Aged ,Phosphodiesterase 5 Inhibitors ,medicine.disease ,Erectile dysfunction ,Cross-Sectional Studies ,chemistry ,Patient Satisfaction ,Family medicine ,Egypt ,business ,Specialist Physician - Abstract
A cross-sectional survey was conducted in Egypt from November 2015 to June 2016. Sexually active adult men were interviewed by a questionnaire designed by the authors. All the participants were evaluated by the abridged 5-item version of the International Index of Erectile Function (IIEF). A total of 3,000 sexually active Egyptian males participated in this study, 946 (31.53%) reported using PDE5Is at least once, and 2054 (68.47%) have never used them. The majority of those who used PDE5Is obtained them for recreational purposes mainly for pleasure (58.35%) and to increase duration/frequency of the intercourse (15.6%). Only 26.05% used PDE5Is to treat ED. The main source of obtaining PDE5Is was friends, relatives and colleagues (62.79%); 25.16% of users obtained the drug by themselves, and 6.66% were prescribed the drug by a pharmacist. Only 5.39% of users obtained the drug after a specialist physician consultation. Sildenafil was the most commonly used PDE5I (90.6%), and most of the users (88.05%) used them in an occasional manner even in the presence of erectile dysfunction, while 11.95% used the drug in a regular manner for every intercourse. PDE5Is are frequently used by the Egyptian male population, and most of them seemed to take them as recreational medications.
- Published
- 2019
29. Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained Infertility
- Author
-
Mohamed Farid Roaiah, Sameh Fayek GamalEl Din, Yasser Ibrahim Elkhayat, and Mohamed Ahmed Abd El Salam
- Subjects
Adult ,Male ,medicine.medical_specialty ,Tribulus terrestris ,030232 urology & nephrology ,Semen ,Serum testosterone level ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Tribulus ,medicine ,Humans ,Outpatient clinic ,Testosterone ,Pharmacology (medical) ,Prospective Studies ,Unexplained infertility ,Nutrition and Dietetics ,Sperm Count ,Plant Extracts ,business.industry ,Testosterone (patch) ,Luteinizing Hormone ,Sperm ,Fertility ,Endocrinology ,Infertility ,030220 oncology & carcinogenesis ,Luteinizing hormone ,business ,Food Science - Abstract
We evaluated the role of Tribulus terrestris in males with unexplained infertility and its effect on serum testosterone and semen parameters. Thirty randomized male patients presenting to Andrology outpatient clinic complaining of idiopathic infertility were selected. They were given Tribulus terrestris (750 mg) in three divided doses for three months. The effect of Tribulus terrestris on serum testosterone (total and free) and luteinizing hormone (LH), as well as its impact on semen parameters in those patients, was studied. No statistically significant difference was observed in the levels of testosterone (total and free) and LH and semen parameters (sperm concentration or motility, or abnormal forms) before and after the treatment. In addition, no statistically significant correlations were observed between testosterone (free and total) and LH and semen parameters before and after the treatment. Tribulus terrestris was ineffective in the treatment of idiopathic infertility.
- Published
- 2016
30. Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study
- Author
-
Omar Ayman Saadeldin, Sameh Fayek GamalEl Din, Ahmed Ragab Ahmed, Mohamed Ahmed Abdel Salam, Ramzy Raafat Elnabarway, Ahmed Tarek Motawaa, and Mohamed Shokr Mohamed
- Subjects
Adult ,Male ,medicine.medical_specialty ,Tribulus terrestris ,Protodioscin ,030232 urology & nephrology ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Erectile Dysfunction ,Lower Urinary Tract Symptoms ,Lower urinary tract symptoms ,Internal medicine ,Androgen deficiency ,medicine ,Tribulus ,Outpatient clinic ,Humans ,Single-Blind Method ,Prospective Studies ,Aged ,030219 obstetrics & reproductive medicine ,business.industry ,Hypogonadism ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Erectile dysfunction ,Treatment Outcome ,chemistry ,International Prostate Symptom Score ,business ,Sexual function ,Phytotherapy - Abstract
Aging is associated with a series of morphological and functional modifications that leads to reduced physiological efficiency and atrophy of various organs and systems. Tribulus terrestris induces its effect in fertility and sexual functions through the steroidal saponins, particularly the dominant saponins protodioscin. We aimed in this study to evaluate the efficacy and safety profiles of Tribulus terrestris in aging males with partial androgen deficiency who suffered from erectile dysfunction and lower urinary tract symptoms. A total of 70 randomized aging patients with erectile dysfunction and lower urinary tract symptoms were recruited from June 2017 to March 2018 from our andrology outpatient clinic. Thirty-five patients (group A) received Tribulus terrestris three times daily for 3 months and the other 35 patients (group B) received placebo. The mean of aspartate transaminase was elevated in group A after 3 months of receiving Tribulus terrestris (26.5 (before), 27.8 (after), respectively, p = 0.03). Moreover, there were significant elevations in the means of both total testosterone together with the score of the validated Arabic index of erectile function (5-item version of the International Index of Erectile Function) (2.2, 10.7 (before), 2.7, 16.1 (after), p
- Published
- 2018
31. Can spermatozoa be retrieved in non-obstructive azoospermic patients with high FSH level?: A retrospective cohort study
- Author
-
Asmaa Ahmed Abdel Hamid, Ahmed Ragab Ahmed, Medhat Amer, and Sameh Fayek GamalEl Din
- Subjects
Adult ,Male ,Infertility ,endocrine system ,medicine.medical_specialty ,Sperm Retrieval ,Urology ,030232 urology & nephrology ,Logistic regression ,Sertoli cell-only syndrome ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Statistical significance ,Humans ,Medicine ,Azoospermia ,Retrospective Studies ,urogenital system ,business.industry ,Retrospective cohort study ,General Medicine ,medicine.disease ,Spermatozoa ,Testicular sperm extraction ,030220 oncology & carcinogenesis ,Hormonal therapy ,Follicle Stimulating Hormone ,business - Abstract
We aimed in this retrospective study to evaluate non-surgical preoperative parameters and testicular histopathology in determining the sperm retrieval rate (SRR) in non-obstructive azoospermic (NOA) patients. We evaluated the data of 1,395 consecutive patients who underwent 1st time micro-dissection testicular sperm extraction (micro-TESE) that was done by fifteen different senior andrologists and a consequent undefined number of biologists assisting them in the operative rooms from January 2010 to May 2013 in a specialised IVF centre. Our study did not demonstrate any statistical significance between the mean age, the mean duration of infertility and finally, the mean of FSH levels of the patients with positive and negative micro-TESE outcomes (p-value 0.391, 0.543, 0.767 respectively). Moreover, our study did not demonstrate any association between different types of hormonal therapy prior to micro-TESE and patients with positive micro-TESE outcome (p-value 0.219). Interestingly, our study showed positive associations between the testicular histopathology SCO (sertoli cell only syndrome) and high FSH and sperm retrieval rate (p < 0.001, 0.02 respectively). Logistic regression analysis revealed high statistical significance between sperm retrieval rate and high FSH level and testicular histopathology (OR 1.6, 0.21, 95% CI lower 1.2, 0.008 and upper 2.1, 0.06 and finally p 0.003
- Published
- 2018
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