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El objetivo de este artículo fue identificar los procesos que predicen el estado óptimo de Flow en deportistas universitarios de alto rendimiento. Una muestra de 75 deportistas que participaron en la Universiada Estatal de Sinaloa y en la Universiada Nacional de Monterrey con edades comprendidas entre 18 a 25 años (M = 21,26 DT = 1,89) participaron en esta investigación. Los resultados mostraron que los deportistas presentaron altos niveles en emociones positivas acompañado de un estado optimo de Flow y bajos niveles de ansiedad somática y cognitiva. Por último, cabe señalar que fueron la motivación intrínseca, los afectos positivos, las horas de entrenamiento, los apoyos económicos las variables que predicen un estado óptimo de Flow.

Tackling how racial justice and climate crisis are entangled, this essay introduces a speculative cartography experiment entitled The World We Became: Map Quest 2350. A collaboration between a collective of artists, poets, academics, curators, architects, and activists, this digital humanities project maps global ecological crises and shared Black, Asian, Pacific, Middle Eastern, Latin American, Caribbean, and Indigenous futures. Intentionally produced in a multimedia format, the born-digital speculative design experiment features visual and audio components presenting a planetary vision of the year 2350 as an underwater future in ruins. The atlas connects five transnational imaginaries that rescript the geographic boundaries of what we currently understand to be South Asia, the South Pacific, the Middle East, North America, Latin America, and the Caribbean. Situating nation-state borders as recent constructs, in this creative exercise the natural environment becomes a model for imagining interspecies relationality and co-presence. Mangroves and atolls form portals to speculative futures of non-human existence beyond the climate crisis and the impact of racial extractive capitalism. Anchored in five locales, the collective text brings together a global vision of survivance addressing migration, dispossession, Asian diaspora, Native sovereignty, Black fugitivity, and broader questions of global indigeneity. With life emerging from the ruins, this atlas forms a digital blueprint of suboceanic futures and the practice of interrogating what justice could mean in the far future.

Measure effectiveness of a non-pharmacological approach to manage postoperative nausea (PON) by applying an ice pack to the posterior upper neck.This was an observational quality improvement project. The sample included adults 18 years old and older who received general anesthesia (inhalation and/or intravenous), recovering in Phase I or Phase II postoperative care unit (PACU) experiencing very mild to moderate nausea. Exclusion criteria were patients who experienced severe nausea or were actively vomiting; were admitted for head or neck plastic surgery; were hypothermic (36.0°C); patients who refused the ice pack, or the provider stated that placing an ice pack to the patient's posterior upper neck was contraindicated.Patients who experienced mild to moderate PON had an ice pack applied to the posterior upper neck as first line management. If the patient's nausea continued to progress or did not improve within five minutes of ice pack application the patient was offered a different non-pharmacological approach or pharmacological approach to prevent vomiting as per standards of care. Demographics were collected and patient's level of nausea was documented at the time of ice pack application and after five minutes.Of the 70 patients included in this study, 61% reported ice pack application as effective in mitigating their nausea, 14% were unsure, and 24% reported not effective. There was a significant decrease in nausea between baseline (2.3 ± 0.6; range 1-3) and five minutes post application (1.5 ± 1.1; range 0-4). The within subject baseline-post change (↓0.9 ± 1.1; P.001) reflected a decrease in nausea.Application of an ice pack to the posterior upper neck, may effectively decrease very mild to moderate PON.

Observation of the electrocardiogram (ECG) immediately following return of spontaneous circulation (ROSC) in resuscitated swine has revealed the interesting phenomenon of sudden ECG rhythm changes (SERC) that occur in the absence of pharmacological, surgical, or other medical interventions.We sought to identify, quantify, and characterize post-ROSC SERC in successfully resuscitated swine.We reviewed all LabChart data from resuscitated approximately 4- to 6-month-old swine used for various experimental protocols from 2006 to 2019. We identified those that achieved sustained ROSC and analyzed their entire post-ROSC periods for evidence of SERC in the ECG, and arterial and venous pressure tracings. Presence or absence of SERC was confirmed independently by two reviewers (ACK, DDS). We measured the interval from ROSC to first SERC, analyzed the following metrics, and calculated the change from 60 sec pre-SERC (or from ROSC if less than 60 sec) to 60 sec post-SERC: heart rate, central arterial pressure (CAP), and central venous pressure (CVP).A total of 52 pigs achieved and sustained ROSC. Of these, we confirmed at least one SERC in 25 (48.1%). Two pigs (8%) each had two unique SERC events. Median interval from ROSC to first SERC was 3.8 min (inter-quartile range 1.0-6.9 min; range 16 sec to 67.5 min). We observed two distinct types of SERC: type 1) the post-SERC heart rate and arterial pressure increased (72% of cases); and type 2) the post-SERC heart rate and arterial pressure decreased (28% of cases). For type 1 cases, the mean (standard deviation [SD]) heart rate increased by 33.6 (45.7) beats per minute (bpm). The mean (SD) CAP increased by 20.6 (19.2) mmHg. For type 2 cases, the mean (SD) heart rate decreased by 39.7 (62.3) bpm. The mean (SD) CAP decreased by 21.9 (15.6) mmHg.SERC occurred in nearly half of all cases with sustained ROSC and can occur multiple times per case. First SERC most often occurred within the first 4 minutes following ROSC. Heart rate, CAP, and CVP changed at the moment of SERC. We are proceeding to examine whether this phenomenon occurs in humans post-cardiac arrest and ROSC.

Abstract: Poor dietary habits such as overconsumption of hypercaloric diets characterized by a high content of fructose and fat are related to metabolic abnormalities development such as obesity, diabetes, and dyslipidemia. Accumulating evidence supports the hypothesis that if energy intake gradually exceeds the body's ability to store fat in adipose tissue, the prolonged metabolic imbalance of circulating lipids from endogenous and exogenous sources leads to ectopic fat distribution in the peripheral organs, especially in the heart, liver, and kidney. The kidney is easily affected by dyslipidemia, which induces lipid accumulation and reflects an imbalance between fatty acid supply and fatty acid utilization. This derives from tissue lipotoxicity, oxidative stress, fibrosis, and inflammation, resulting in structural and functional changes that lead to glomerular and tubule-interstitial damage. Some authors indicate that a lipid-lowering pharmacological approach combined with a substantial lifestyle change should be considered to treat chronic kidney disease (CKD). Also, the new therapeutic target identification and the development of new drugs targeting metabolic pathways involved with kidney lipotoxicity could constitute an additional alternative to combat the complex mechanisms involved in impaired kidney function. In this review article, we first provide the pathophysiological evidence regarding the impact of hypercaloric diets, such as high-fat diets and high-fructose diets, on the development of metabolic disorders associated with impaired renal function and the molecular mechanisms underlying tissue lipid deposition. In addition, we present the current progress regarding translational strategies to prevent and/or treat kidney injury related to the consumption of hypercaloric diets.

Últimamente, el mobbing o acoso laboral, se ha entendido como un tipo de violencia psicológica dentro del trabajo y se ha convertido en uno de los problemas más graves en las empresas, sobre todo en las pymes, cuyo futuro depende de factores como ventas, rendimiento y desarrollo del negocio. La mayoría de ellas, no se dan cuenta del gran daño que puede ocasionar éste problema a su capital humano y por ende, al proceso de crecimiento de su negocio, por lo que es de vital importancia la detección temprana de estos casos negativos, seguido de la necesidad de realizar intervenciones para minimizar o evitar por completo este tipo de problemas, trabajando tanto vertical como horizontalmente en análisis de fondo, para proceder a utilizar las estrategias que permitan combatirlo; empezando desde la alta dirección, administradores de recursos humanos y seguidos por los líderes de los departamentos de la empresa, hasta llegar a los operarios y empleados generales, para de esta forma obtener un clima laboral favorable para todos.

El presente artículo busca abrir el diálogo sobre una dimensión poco explorada de la obra y la teoría de Oscar Correas, su íntimo vínculo con la teoría posestructuralista a través de la influencia dentro de su perspectiva marxista, de la crítica a la metafísica que retoma de Oscar del Barco, quien a su vez se vio profundamente influenciado por autores como Deleuze y Derrida. Aspiramos, a través de un análisis de los conceptos de ideología e inversión en la obra de Correas, a mostrar algunas de las líneas de investigación que se abren como posibilidades en el contexto de este diálogo.

El objetivo de la investigación es determinar la percepción de los estudiantes de nivel superior respecto al emprendimiento, a través de una encuesta elaborada por expertos, que permita conocer sus puntos de vista sobre su creatividad, visión empresarial y la posibilidad de implementar su idea de negocio. El método es de enfoque cuantitativo, ya que los datos son cuantificables y permiten la objetividad de los resultados al dirigirse a una determinada muestra de la población; su alcance es exploratorio, porque indaga en problemas o temas sobre los que existe escasa documentación, y es descriptivo, porque detalla cual es el perfil de los participantes recabando todos los datos posibles que contribuyan a la investigación. Finalmente es transaccional, ya que la toma de datos de campo se efectuó en una sola ocasión y en un determinado lugar. Se puede concluir que los estudiantes universitarios cuentan con una percepción favorable respecto al emprendimiento, sin embargo, algunos manifiestas temor a ser empresarios por el riesgo al fracaso, específicamente por no contar con las habilidades suficientes o por la falta de una inspiración que los motive a salir de su estatus quo. Existe una línea muy delgada entre hombres y mujeres en cuestión de iniciativa al decidir emprender, la edad de mayor interés es de 18 a 22 años y estado civil solteros.

Familism is a central cultural value endorsed by Latinx youth that has been identified as a promotive factor for their psychological wellbeing (Stein et al., 2014). However, in the context of familial stress, familism values may instead serve to increase risk, but this research has not been extended to consider parental alcohol use as a risk context. Using a sample of 167 Latinx youth (Mage = 12.86, SD = 0.68, 52% female) from an immigrant community in the Southeast, we tested whether parental alcohol use moderated the association between familism values and youth depressive symptoms and self-esteem. Youth familism values were associated with greater self-esteem and fewer depressive symptoms. Parental alcohol use was not associated directly with either outcome, but, consistent with hypotheses, significantly interacted with familism values to predict self-esteem such that the promotive effect of familism on youth's self-esteem was not evident when parental alcohol use was high. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The tractive force developed by energy consumption (EC) in a car engine produces its acceleration and sustains the motion against velocity dependent resistance forces. In internal combustion engines, fuel burning entails pollutant emissions (PE) released into the atmosphere. In vehicular traffic, EC and PE depend on the driving style. This paper assumed that the transition rules in a traffic cellular automata (TCA) represent a driving style, and its effect on EC and PE in TCA is studied. Extending empirical relationships, we proposed models to estimate EC and PE in TCA from the velocity and acceleration distributions, which we obtained by computer simulations for three well-known TCA. The Nagel-Schreckenberg (NS) and Fukui-Ishibashi (FI) models, and a variant (NS+FI) defined by combining the NS and FI rules, were considered. The FI driving style revealed EC and CO2 emission rates dependent on the stochastic delay (p) only for low vehicular densities. We also detected that the larger EC and CO2 emission rates were 45.4 kW and 26.7 g/s with no dependence on p. With NS and NS+FI driving styles, the larger energy consumption and CO2 emission rates occurred for small stochastic delays, 18.4 kW and 6.6 g/s and 61.1kW and 30.2 g/s for p = 0.2. On average, for NS, FI, and NS+FI models (p = 0.2), we obtained energy consumptions of 1.88, 2.60, and 2.76 MJ/km, fuel consumptions of 0.08, 0.12, and 0.13 L/km, and CO2 emissions of 0.158, 0.460, and 0.562 kgCO2/km. Our results agree with those (3.37 MJ/km and 0.235 kgCO2/km) of petrol combustion car engines at 10 km/L. This work may help in designing flow and driving style scenarios to optimize vehicular traffic EC and reduce PE.

Neuron-microglia communication through the Cx3cr1-Cx3cl1 axis is essential for the development and refinement of neural circuits, which determine their function into adulthood. In the present work we set out to extend the behavioral characterization of Cx3cr1

El caracol Megastraea undosa forma parte de las pesquerías de recursos bentónicos económicamente importantes de la costa occidental de Baja California Sur, México. Los estudios sobre su densidad y estructura de tallas son importantes debido a que forman parte de las evaluaciones de stock en apoyo al manejo de su pesquería. El objetivo de este trabajo fue determinar las variaciones espacio-temporales de la densidad y estructura de tallas del caracol M. undosa en la costa occidental de Baja California Sur, México. Se determinó la estructura de tallas por sitio de muestreo y se analizó con base en la talla mínima legal y por zona de pesca. En el análisis espacial, la densidad (ind. m-2) y talla promedio se analizaron por estrato de profundidad y zona de pesca. El análisis temporal, densidad y talla promedio fueron analizadas por estrato de profundidad, únicamente para la zona 3, en el periodo comprendido desde 1999-2014. Los resultados demostraron diferencias espaciales de la densidad y talla promedio del caracol M. undosa en la costa occidental de Baja California Sur, y en el sitio de pesca más sureño dominaron las tallas pequeñas. Se discuten las variaciones espacio-temporales de la densidad y estructura de tallas en función de la disponibilidad de macroalgas, así como de la temperatura superficial del mar y las surgencias estacionales. El conocimiento del comportamiento espacio-temporal de la talla y densidad de M. undosa servirá de base para su futuro manejo, con base en un enfoque biológico o bioeconómico para el establecimiento de puntos de referencia.

Objectives: To estimate the self-reported prevalence of gluten-related disorders (GRDs) and adherence to a gluten-free diet (GFD) in a Colombian population and to obtain the characteristics of GFD followers, gluten avoiders, and non-avoiders. Material and Methods: A survey was conducted using a culturally adapted and validated questionnaire. Results: Considering 850 valid responses (52.12%), the prevalence rates were/95% CI: Recurrent adverse reactions to wheat/gluten (RAR-W/G) 9.29%/7.52-11.43, wheat allergy 0.47%/0.18-1.20, non-celiac gluten sensitivity (NCGS) 2.35%/1.52-3.60, and GFD adherence 6.94%/5.41-8.85. No celiac disease (CD) cases were found. Most GRDs diagnoses were symptom-based (85.71%). Among 79 RAR-W/G or 100 irritable bowel syndrome (IBS) cases, only 8/79 and 5/100 had a physician diagnosis of NCGS, but celiac tests were informed by only one case. Health professionals were instructing the GFD in 49.15% of the GFD cases. GFD adherence motivations included weight control (74.42%) and the perception that a GFD promotes health (46.51%). Conclusions: There is a potential subdiagnosis of CD in Colombia, and even the majority of those with a physician diagnosis of IBS and RAR-W/G do not have undergone CD assessment. Similarly, physician-diagnosed NCGS cases rarely undergo celiac tests, raising questions about the optimal patient’s diagnosis and follow-up. Finally, the Colombian population should be informed about the risks/benefits of following a GFD without professional counseling. Keywords: Gluten, NCGS, Celiac Disease.

Upcoming large-scale structure surveys will measure the matter power spectrum to approximately percent level accuracy with the aim of searching for evidence for new physics beyond the standard model of cosmology. In order to avoid biasing our conclusions, the theoretical predictions need to be at least as accurate as the measurements for a given choice of cosmological parameters. However, recent theoretical work has shown that complex physical processes associated with galaxy formation (particularly energetic feedback processes associated with stars and especially supermassive black holes) can alter the predictions by many times larger than the required accuracy. Here we present $\texttt{SP(k)}$, a model for the effects of baryon physics on the non-linear matter power spectrum based on a new large suite of hydrodynamical simulations. Specifically, the ANTILLES suite consists of 400 simulations spanning a very wide range of the "feedback landscape" and show that the effects of baryons on the matter power spectrum can be understood at approaching the percent level in terms of the mean baryon fraction of haloes, at scales of up to $k \lesssim 10 \, h \, $Mpc$^{-1}$ and redshifts up to $z=3$. For the range of scales and redshifts that will be probed by forthcoming cosmic shear measurements, most of the effects are driven by galaxy group-mass haloes ($M \sim 10^{13-14}$ M$_\odot$). We present a simple Python implementation of our model, available at $\href{https://github.com/jemme07/pyspk}{\mathrm{https{:}//github.com/jemme07/pyspk}}$, which can be used to incorporate baryon effects in standard gravity-only predictions, allowing for marginalisation over baryon physics within cosmological pipelines., Comment: Refereed version accepted for publication in Monthly Notices of the Royal Astronomical Society (MNRAS). 16 pages, 11 figures

Participation in research experiences and internships may improve graduation rates and persistence in science, technology, engineering, and mathematics (STEM) among undergraduates, yet very little is known about the benefits of these activities for community college students. To fill this gap, we collected survey and interview data from 43 individuals who completed the Community College Internship (CCI) at Lawrence Berkeley National Laboratory (LBNL). These “CCI alumni” reported gains, including: connections with members of the LBNL community (95%); higher expectations of academic or career success (91%); development of critical skills (88%); and increased self-efficacy and/or confidence (84%), STEM identity (70%), and knowledge about STEM careers (65%). Of this group, 12% are graduate students, 84% have entered the STEM workforce, and 5% have entered the health workforce. We hope this work will encourage other scholars to contribute to what is known about the impact of internships at national laboratories on STEM majors.

Wildlife play prominent roles in popular images of America’s outdoor landscapes, yet our understanding of their contribution to place meanings is not fully developed. Although environmental management agencies have a long history of stewarding wildlife for hunting and fishing, they have been less inclined to prioritize non-consumptive uses such as the contribution of wildlife to sense of place. Given that agencies are increasingly challenged to implement policies that align with citizen priorities, connecting wildlife to sense of place could lead to more effective decisions. Our research explored the plurality of connections that residents made with wildlife in multiple protected areas across the USA region of Interior Alaska. Residents of nine communities were engaged over a five-year period, followed by a thematic analysis of interview data, which resulted in the identification of seven place meaning themes. These themes reflected qualities of the local environment that were appreciated by residents, including: 1) desirable travel destination, 2) distinct sense of community, 3) landscape of subsistence and tradition, 4) landscape of wildlife habitat, 5) natural resources in need of harvesting, 6) rural Alaskan lifestyle, and 7) wildland areas tied to recreation. Native wildlife species – from traditionally charismatic species like moose (Alces alces) to less iconic species such as snowshoe hare (Lepus americanus) – were discussed in the context of all seven place meaning themes. Wildlife provided a basis for study participants to interpret landscapes and ascribe meanings to places, thus supporting our argument that shared influences of wildlife and place meanings should be prioritized in environmental planning and management.

Background The objective of the study to determine if a nurturing care parenting programme delivered in a humanitarian setting in Rwanda to determine would benefit early development, learning and care outcomes for young children under 5 years and their caregivers compared to standard care. Methodology The parenting programme was implemented in Rwanda’s Mugombwa, Kansi and Kigeme refugee camp and host communities. Via a quasi-experimental research design, the study assessed the effects of intervention delivered as high dose (HD: 12 group sessions and 4 home visits) or low dose (LD: 6 group sessions and 2 home visits) on child and caregiver outcomes compared to the control group from similar settings receiving standard care. Child development outcomes were assessed using the Ages and Stages Questionnaires (ASQ). Parenting practices with respect to early learning and stimulation were assessed using standard questionnaires. Findings A total of 733 children and families were assessed: HD = 314, LD = 240, control = 179. No significant difference on child development scores between intervention and control groups was found. Caregivers exposed to HD and LD packages had significantly higher scores on early learning and stimulation practices compared to the control group respectively with 211(67.2%), 148 (61.7%) vs. 66 (36.9%), p Conclusion Parenting programmes in humanitarian settings can positively impact on nurturing care practices, even with a low dose, which are essential to strengthening children’s resilience living in at-risk conditions such as refugee settings. Further studies in such context are essential to strengthen the proof of concept from the study findings.

Objective: to analyze income inequality with the contribution of remittances received directly and eliminating this contribution, to achieve this a comparison will be made with the Gini index. Methodology: the analysis was applied to households in the state of Sinaloa and the variable of interest was the income of the heads of household together with the remittance variable and without the remittance variable. Results: it is evident that the average income suffers an increase even when the percentage of the population receiving remittances is less than 7 percent. Limitation: for the analysis, variables were homogenized and created since the database during the study period reflected important changes in its structure. Originality: We report the empirical importance with theoretical support by showing the role of remittances for a state based on agricultural activities. Conclusions: Remittances have a greater impact on the reduction of inequality in rural areas, due to the migration of the rural community of the state studied.

This paper describes the importance of commercial distribution, its main functions and addresses the different Push strategies that are carried out in the convenience stores of the city of Los Mochis, taking into account the relevance of this type of business in the locality. business units in economic terms, the objective is to detect which have a greater degree of significance in the sales channel, for this a qualitative research approach was used, conducting a series of interviews with those responsible for these businesses, observing the processes of marketing and consulting secondary information sources, which brought with it revealing data regarding promotions, the importance of islands, POP material and canopies for sale and other strategies that have a significant effect on sales.

The draft Post-2020 Global Biodiversity Framework commits to achievement of equity and justice outcomes and represents a “relational turn” in how we understand inclusive conservation. Although “inclusivity” is drawn on as a means to engage diverse stakeholders, widening the framing of inclusivity can create new tensions with regard to how to manage protected areas. We first offer a set of tensions that emerge in the light of the relational turn in biodiversity conservation. Drawing on global case examples applying multiple methods of inclusive conservation, we then demonstrate that, by actively engaging in the interdependent phases of recognizing hybridity, enabling conditions for reflexivity and partnership building, tensions can not only be acknowledged but softened and, in some cases, reframed when managing for biodiversity, equity, and justice goals. The results can improve stakeholder engagement in protected area management, ultimately supporting better implementation of global biodiversity targets.

The Localized Agri-Food Systems (Sial, in Spanish) approach has paid little attention to Participatory Certifications (PC) as a result of relationships of trust and solidarity between producers and consumers into the alternative markets, which have acquired relevance in light of the COVID-19 pandemic. This article asks if these markets and the CPs are an expression of consumer recognition of the quality and origin of agrobiodiversity products from traditional agri-food systems; and if the alternative markets are a sign of a new food paradigm. To answer these questions, a three-stage investigation was carried out in Mexico City with qualitative mixed techniques. The results show that there is an emergence of these markets, but also a differentiation, both in the forms of distribution and in the opinions about the PC derived from the difficulties and opportunities of these forms of marketing., El enfoque de los Sistemas Agroalimentarios Localizados (Sial) ha prestado poca atención a las Certificaciones Participativas (CP), como producto de las relaciones de confianza y solidaridad entre productores y consumidores en los mercados alternativos, los que han adquirido relevancia a la luz de la Pandemia de COVID-19. Las preguntas de investigación son si esos mercados y las CP son una expresión del reconocimiento del consumidor sobre la calidad y el origen de los productos de la agrobiodiversidad proveniente de los agroecosistemas tradicionales; y si constituyen atisbos de un patrón alimentario emergente. Para responderlas, se llevó a cabo una investigación en tres etapas en la Ciudad de México con técnicas mixtas cualitativas. Los resultados muestran una emergencia de esos mercados, pero también una diferenciación, tanto de las formas de distribución como de las opiniones sobre las CP derivadas de las dificultades y oportunidades que presentan estas formas de comercialización.

Background: Dyslipidemia and obesity hypercaloric diet-induced lead to kidney damage. We investigated the effect of curcumin on the expression of proteins related to inflammation, fibrosis, fatty acids metabolism, kidney damage, and morphological changes in the kidney of mice hypercaloric diets-fed. Methods: Groups of 5-week-old C57BL/6 mice (n=6) were formed: Control (C), High-fructose diet (F), High-fructose diet and curcumin (F+Cur), High-fat diet (HFD), High-fat diet and curcumin (HFD+Cur), High-fat diet and fructose (HFD+F), High-fat diet, fructose and curcumin (HFD+F+Cur), treated for 16 weeks with 30% (w/v) fructose, 60% (w/w) fat and 0.75% (w/w) curcumin. Kidneys were obtained for histomorphological and Western Blot analysis. Results: Curcumin prevented TNF-α overexpression in the F and HFD+F groups. VLCAD expression was higher in the F, HFD, and HFD+F groups. PPARγ expression was lower in the F+Cur, HFD+Cur, and HFD+F+Cur groups. Curcumin prevented overexpression of CPT1 and KIM1 in the HFD+F and HFD groups. Curcumin prevented morphological lesions, fibrosis, and lipid deposition hypercaloric diet-induced. Conclusion: Chronic consumption of hypercaloric diets causes inflammation, fibrosis, and lipid deposition in the kidney. It is suggested that curcumin differentially modulates kidney injury as a function of the damage induced by the high-fat/high-fructose diet.

In early 2021, effective SARS-CoV-2 (COVID-19) vaccines became available in the United States; by mid-April 2021, vaccine availability outstripped demand, daily vaccination rates peaked, and COVID-19 vaccines were found highly effective in adult populations. Accurate estimates of the number of vaccine-preventable deaths had higher vaccination rates been attained could have helped local policymakers and possibly persuaded more to get vaccinated. Because existing estimation methodologies are limited, for the period 1/1/21 – 4/30/22, we simulated the number of vaccine-preventable deaths associated with two-dose COVID-19 vaccination that incorporated state-level population, death, and vaccination numbers and three scenarios of vaccination rate achievement. Nationally, we found that had 100% of the population became fully vaccinated during the period examined, 318,979 deaths, or approximately 50% of actual COVID-19 deaths, might have been prevented; had 85% been so, 28% might have been prevented. Across states, we found substantial variation in the proportion of avoidable COVID-19 deaths that might have been avoided at the state level, from 25% in Massachusetts to 74% in Alaska. Our findings are sobering when considering the painful deaths, the survivors’ anguish, and the diversion of scarce and expensive healthcare resources that might have been averted had peak vaccination administration efforts been maintained.

Supplemental material for Myocardial protection using single dose del Nido Cardioplegia with and without topical cooling by Marcin Malinowski, Monica Solarewicz, Ryan Farley, Jose Rios Salcido, Jared Bush, Brian MacDoughall, Jennifer Bromberg-White and Tomasz A Timek in Perfusion

Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counter-intuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, $\alpha=2$ as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed $>$600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: pre-flare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that $\alpha = 1.63 \pm 0.03$. This is below the critical threshold, suggesting that Alfv\'en waves are an important driver of coronal heating., Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The Astrophysical Journal on 2023-05-09, volume 948, page 71

To fully take advantage of the data provided by large-scale structure surveys, we need to quantify the potential impact of baryonic effects, such as feedback from active galactic nuclei (AGN) and star formation, on cosmological observables. In simulations, feedback processes originate on scales that remain unresolved. Therefore, they need to be sourced via subgrid models that contain free parameters. We use machine learning to calibrate the AGN and stellar feedback models for the FLAMINGO cosmological hydrodynamical simulations. Using Gaussian process emulators trained on Latin hypercubes of 32 smaller-volume simulations, we model how the galaxy stellar mass function and cluster gas fractions change as a function of the subgrid parameters. The emulators are then fit to observational data, allowing for the inclusion of potential observational biases. We apply our method to the three different FLAMINGO resolutions, spanning a factor of 64 in particle mass, recovering the observed relations within the respective resolved mass ranges. We also use the emulators, which link changes in subgrid parameters to changes in observables, to find models that skirt or exceed the observationally allowed range for cluster gas fractions and the stellar mass function. Our method enables us to define model variations in terms of the data that they are calibrated to rather than the values of specific subgrid parameters. This approach is useful, because subgrid parameters are typically not directly linked to particular observables, and predictions for a specific observable are influenced by multiple subgrid parameters., Comment: 24 pages, 10 figures (Including the appendix). Submitted to MNRAS. For visualisations, see the FLAMINGO website at https://flamingo.strw.leidenuniv.nl/

We introduce the Virgo Consortium's FLAMINGO suite of hydrodynamical simulations for cosmology and galaxy cluster physics. To ensure the simulations are sufficiently realistic for studies of large-scale structure, the subgrid prescriptions for stellar and AGN feedback are calibrated to the observed low-redshift galaxy stellar mass function and cluster gas fractions. The calibration is performed using machine learning, separately for three resolutions. This approach enables specification of the model by the observables to which they are calibrated. The calibration accounts for a number of potential observational biases and for random errors in the observed stellar masses. The two most demanding simulations have box sizes of 1.0 and 2.8 Gpc and baryonic particle masses of $1\times10^8$ and $1\times10^9 \text{M}_\odot$, respectively. For the latter resolution the suite includes 12 model variations in a 1 Gpc box. There are 8 variations at fixed cosmology, including shifts in the stellar mass function and/or the cluster gas fractions to which we calibrate, and two alternative implementations of AGN feedback (thermal or jets). The remaining 4 variations use the unmodified calibration data but different cosmologies, including different neutrino masses. The 2.8 Gpc simulation follows $3\times10^{11}$ particles, making it the largest ever hydrodynamical simulation run to $z=0$. Lightcone output is produced on-the-fly for up to 8 different observers. We investigate numerical convergence, show that the simulations reproduce the calibration data, and compare with a number of galaxy, cluster, and large-scale structure observations, finding very good agreement with the data for converged predictions. Finally, by comparing hydrodynamical and `dark-matter-only' simulations, we confirm that baryonic effects can suppress the halo mass function and the matter power spectrum by up to $\approx20$ per cent., Comment: 43 pages, 23 figures. Submitted to MNRAS. For visualisations, see the FLAMINGO website at https://flamingo.strw.leidenuniv.nl/

El grupo de investigación Hydra Transfilosofía Escénica trabaja en los intersticios entre la metáfora y el concepto, el acontecimiento y la teoría. Desde el trabajo interdisciplinario, triangula el seminario teórico, la escritura de textos académicos y el arte acción, en busca de un desarrollo orgánico de ideas, de un pensamiento sostenido en los juegos del cuerpo. El presente artículo aborda las problemáticas teóricas a las que arroja el concepto de transfilosofía escénica, como propio de un discurso que se articula de manera escénico-teórica, asumiendo al arte acción como una toma de postura: el arte como experimento filosofante. Performance transphilosophy: conceptual becoming of the body and Situationist writing Abstract The Hydra Transfilosofía Escénica research group works in the interstices between metaphor and concept, event and theory, with an interdisciplinary approach. The group brings together a theoretical seminar, the writing of academic texts and action art interventions, in search of an organic development of ideas sustained by a ludic approach to the body. This article addresses the theoretical challenges posed by concept of performance transphilosophy, assuming action art as a stance, and art as a philosophical experiment.

La desregulación emocional en edades tempranas, como la adolescencia, actúa como un factor de riesgo de suicidio. Es por ello que el objetivo del presente estudio fue analizar el nivel predictivo de la desregulación emocional en la ideación suicida. Para ello, se aplicaron los instrumentos Detección de Ideación Suicida en Jóvenes, conjuntamente con un cuestionario de identificación personal, la Escala de Ideación Suicida de Roberts y la Escala de Dificultades en la Regulación Emocional en español a 109 adolescentes de educación media superior. Los resultados obtenidos señalan que el modelo explica 22% de la varianza y que es significativo, hallándose en consecuencia que la desregulación emocional predice la ideación suicida.