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Pedagogical conditions of motivation formation for the development of communicative competence of future specialists in socionomic professions during seminars and practical classes online and offline using interactive methods are defined in the article. The purpose of the article is to substantiate the pedagogical conditions that allow to form future specialists’competences who get higher education in the specialty 081 “Law” at the first (bachelor’s) level, motivation for the development of their communicative competence in the process of studying psychological disciplines. Methodology of the article. The disclosure of the theoretical foundations of pedagogical conditions in order to form communicative competence of future specialists of socionomic professions is based on the analysis of interactive methods and technologies used in the educational process. Theoretical and methodological basis of the article consists of didactic principles and teaching theories, as well as a system of interactive methods and tools that ensure the development of communicative abilities of future professionals in socionomic professions. Results. Substantiation of pedagogical conditions for communicative competence formation of future specialists of socionomic professions at different stages of education in a higher educational institution: adaptation, formation, primary professionalization. To this end, the analysis of publications of both domestic and foreign scholars on the subject, which identified pedagogical conditions necessary for the development of basic communication skills, mastering the technique of interpersonal interaction, forming an individual style of communication by using verbal and nonverbal means, develop the ability to self-presentation. Practical significance of the results is determined by the development of recommendations for teachers who create pedagogical conditions for forming communicative competence of future specialists in socionomic professions to master psychological technique of persuasion and suggestion, individual communication style, ability to resist manipulation, ability to express empathy as an emotional response. Substantiated pedagogical conditions for forming communicative competence of future specialists in socionomic professions must be taken into account in the educational process that will ensure their willingness to cooperate, generalize, analyze and perceive information, the ability to present the ideas logically and reasonably. Value (originality). The originality of the research reveals itself in the fact that it combines different approaches to creating pedagogical conditions for forming communicative competence of future specialists in socionomic professions, in the process of their education in higher educational institution both online and offline. Key words: future specialists, socionomic professions, communicative competence, pedagogical conditions, stages of training, independent study, methods, technologies.

SummarySpine and spinal cord injuries as a combat casualty are important in providingmilitary assistance to military personnel of the Armed Forces of Ukraine during combatoperation in eastern Ukraine and account for 1.1% of all sanitary casualties in thecontext of Antiterrorist Operation / Operation of Joint Forces. Such injury may be eventhree times more common in the structure of combat casualties. Often, injured patientswith spinal cord trauma remain unfit for further military service and require lifelongcare. Recently, treatment for recovery of sensory and motor function below the spinalcord injury area was primarily focused on traditional treatment and rehabilitationmethods, but new advances can significantly improve the prognosis of such patients,including the use of electrical stimulation devices. The case from this articledemonstrates the capabilities of such devices in the treatment of servicemen with spinalcord injury accompanied by impaired both motor and sensory function.

Influenza virus continues to remain one of the leading human respiratory pathogens causing significant morbidity and mortality around the globe. Due to short-term life cycle and high rate of mutations influenza virus is able to rapidly develop resistance to clinically available antivirals. This makes necessary the search and development of new drugs with different targets and mechanisms of activity. Here we report anti-influenza activity of camphor derivative 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol (camphecene). In in vitro experiments it inhibited influenza viruses A(H1, H1pdm09, H3 and H5 subtypes) and B with EC50's lying in micromolar range. Due to low cytotoxicity it resulted in high selectivity indices (74-661 depending on the virus). This effect did not depend on susceptibility or resistance of the viruses to adamantane derivatives amantadine and rimantadine. The compound appeared the most effective when added at the early stages of viral life cycle (0-2h p.i.). In direct hemagglutinin inhibition tests camphecene was shown to decrease the activity of HA's of influenza viruses A and B. The activity of camphecene was further confirmed in experiments with influenza virus-infected mice, in which, being used orally by therapeutic schedule (once a day, days 1-5 p.i.) it decreased specific mortality of animals infected with both influenza A and B viruses (highest indices of protection 66.7% and 88.9%, respectively). Taken together, these results are encouraging for further development of camphecene-based drug(s) and for exploration of camphor derivatives as highly prospective group of potential antivirals.

INTRODUCTION. Upper extremity fractures comprise 84 % of all extremity fractures in children.MATERIAL AND METHODS. In 2004–2013, 504 operations were performed in children aged 5 to 17 years for various injuries of the upper extremity using image intensifiers, in Minsk clinical centre of Trauma and orthopaedics of 6th Minsk clinical Hospital (children’s Department)RESULTS. Immediate results were good or excellent in 98.8 % of patients. In 1.2 % of patients, post-traumatic transient neuropathy of the radial and median nerves was observed.CONCLUSIONS. Minimally invasive operations with image intensifiers performed to treat injuries of the upper extremity in children are highly effective and allow open reduction and skeletal traction to be avoided.

Graphical abstract, The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.

A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.

Graphical abstract, Influenza is a continuing world-wide public health problem that causes significant morbidity and mortality during seasonal epidemics and sporadic pandemics. The purpose of the study was synthesis and investigation of antiviral activity of camphor-based symmetric diimines and diamines. A set of C2-symmetric nitrogen-containing camphor derivatives have been synthesized. The antiviral activity of these compounds was studied against rimantadine- and amantadine-resistant influenza virus A/California/7/09 (H1N1)pdm09 in MDCK cells. The highest efficacy in virus inhibiting was shown for compounds 2a–e with cage moieties bound by aliphatic linkers. The therapeutic index (selectivity index) for 2b exceeded that for reference compounds amantadine, deitiforin and rimantadine almost 10-fold. As shown by structure–activity analysis, the length of the linker has a dramatic effect on the toxicity of compounds. Compound 2e with –C12H24– linker exhibited the lowest toxicity (CTD50 = 2216 μM). Derivatives of camphor, therefore, can be considered as prospective antiinfluenza compounds active against influenza viruses resistant to adamantane-based drugs.

Sub-10-fs visible pulses allow real time detection of coherent phonons in single-walled carbon nanotubes. Nonlinear coupling between radial breathing (250 cm(-1)) and the carbon-stretching ( 1600 cm(-1)) modes is experimentally observed and theoretically modeled.