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2. Development of Quantum Limited Superconducting Amplifiers for Advanced Detection

Author

S. Pagano, C. Barone, M. Borghesi, W. Chung, G. Carapella, A. P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, A. Greco, C. Kutlu, A. Leo, C. Ligi, G. Maccarrone, B. Margesin, G. Maruccio, A. Matlashov, C. Mauro, R. Mezzena, A. G. Monteduro, A. Nucciotti, L. Oberto, V. Pierro, L. Piersanti, M. Rajteri, A. Rettaroli, S. Rizzato, Y. K. Semertzidis, S. Uchaikin, A. Vinante, Pagano, Sergio, Barone, Carlo, Borghesi, Matteo, Chung, Woohyun, Carapella, Giovanni, Caricato, Anna Paola, Carusotto, Iacopo, Cian, Alessandro, Di Gioacchino, Daniele, Enrico, Emanuele, Falferi, Paolo, Fasolo, Luca, Faverzani, Marco, Ferri, Elena, Filatrella, Giovanni, Gatti, Claudio, Giachero, Andrea, Giubertoni, Damiano, Greco, Angelo, Kutlu, Caglar, Leo, Angelo, Ligi, C., Maccarrone, Giovanni, Margesin, Benno, Maruccio, Giuseppe, Matlashov, Andrei, Mauro, Costantino, Mezzena, Renato, Monteduro, Anna Grazia, Nucciotti, Angelo, Oberto, Luca, Pierro, Vincenzo, Piersanti, Luca, Rajteri, Mauro, Rizzato, Silvia, Semertzidis, Yannis K, Uchaikin, Sergey V., Vinante, Andrea, Pagano, S, Barone, C, Borghesi, M, Chung, W, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Greco, A, Kutlu, C, Leo, A, Ligi, C, Maccarrone, G, Margesin, B, Maruccio, G, Matlashov, A, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Semertzidis, Y, Uchaikin, S, and Vinante, A

Subjects
Josephson junctions, Superconducting microwave devices, Microwave amplifiers, Physics, superconducting microwave device, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Physics, Superconducting microwave devices,Bandwidth, Power transmission lines, Josephson junctions, Microwave amplifiers, Inductance, Bandwidth, Josephson junction, Power transmission lines, Superconducting device noise, microwave amplifier, Electrical and Electronic Engineering, Inductance
Abstract

Ultralow-noise microwave amplification and detection play a central role in different applications, going from fundamental physics experiments to the deployment of quantum technologies. In many applications the necessity of reading multiple detectors, or cavities or qubits, calls for large bandwidth amplifiers with the lowest possible noise. Current technologies are based on High Electron Mobility Transistors and Josephson Parametric Amplifiers. Both have limitations, the former in terms of the minimum noise, the latter in terms of bandwidth. Superconducting Traveling Wave Parametric Amplifiers (TWPAs) have the potential of offering quantum limited noise and large bandwidth. These amplifiers are based on the parametric amplification of microwaves traveling along a transmission line with embedded nonlinear elements. We are developing superconducting TWPAs based both on Josephson junction arrays (Traveling Wave Josephson Parametric mplifiers) and on nonlinear kinetic inductance (Dispersion Engineered Traveling Wave Kinetic Inductance Amplifiers). Our goal is to achieve large bandwidth (in the 5 to 10 GHz range), large gain (more than 20 dB), large saturation power (more than -50 dBm), and near quantum limited noise (noise temperature less than 600 mK). Current achievements in the design and development of the high performance TWPAs are here reported and discussed, together with current limitations and possible future developments.

Published
2022
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3. Investigation of Resonant Activation in a Josephson Junction for Axion Search With Microwave Single Photon Detection

Author

F. Chiarello, D. Alesini, D. Babusci, C. Barone, M. M Beretta, B Buonomo, A. D'Elia, D. Di Gioacchino, G. Felici, G. Filatrella, L. G Foggetta, A. Gallo, C. Gatti, C. Ligi, G. Maccarrone, F. Mattioli, S. Pagano, L. Piersanti, A. Rettaroli, S. Tocci, and G. Torrioli

Subjects
Josephson junctions, Axions, Microwave, Single photon, Electrical and Electronic Engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Published
2022
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4. Nasopharyngeal morphology contributes to understanding the 'muddle in the middle' of the Pleistocene hominin fossil record

Author

Anthony S. Pagano, Christopher M. Smith, Antoine Balzeau, Samuel Márquez, and Jeffrey T. Laitman

Subjects
Histology, Fossils, Nasopharynx, Animals, Humans, Hominidae, Anatomy, Biological Evolution, Ecology, Evolution, Behavior and Systematics, Neanderthals, Biotechnology
Abstract

The late archeologist Glynn Isaac first applied the term "muddle in the middle" to a poorly understood period in the Middle Pleistocene human fossil record. This study uses the nasopharyngeal boundaries as a source of traits that may inform this unclear period of human evolution. The nasopharynx lies at the nexus of several vital physiological systems, yet relatively little is known about its importance in human evolution. We analyzed a geographically diverse contemporary Homo sapiens growth series (n = 180 adults, 237 nonadults), Homo neanderthalensis (La Chapelle aux Saints 1, La Ferrassie 1, Forbes Quarry 1, Monte Circeo 1, and Saccopastore 1), mid-Pleistocene Homo (Atapuerca 5, Kabwe 1, Petralona 1, and Steinheim 1), and two Homo erectus sensu lato (KNM-ER 3733 and Sangiran 17). Methods include traditional (Analysis 1) and 3D geometric morphometric analysis (Analysis 2). H. erectus exhibited tall, narrow nasopharyngeal shape, a robust, ancestral morphology. Kabwe 1 and Petralona 1 plotted among H. sapiens in Analysis 2, exhibiting relatively shorter and vertical cartilaginous Eustachian tubes and vertical medial pterygoid plates. Atapuerca 5 and Steinheim 1 exhibited horizontal vomeral orientation similar to H. neanderthalensis, indicating greater relative soft palate length and anteroposterior nasopharynx expansion. They may exhibit synapomorphies with H. neanderthalensis, supporting the accretionary hypothesis. Species-level differences were found among H. sapiens and H. neanderthalensis, including relatively longer dilator tubae muscles and extreme facial airorhynchy among Neanderthals. Furthermore, H. neanderthalensis were autapomorphic in exhibiting horizontal pterygoid plate orientation similar to human infants, suggesting that they may have had inferiorly low placement of the torus tubarius and Eustachian tube orifice on the lateral nasopharyngeal wall in life. This study supports use of osseous nasopharyngeal boundaries both for morphological characters and understanding evolution of otitis media susceptibility in living humans.

Published
2022
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7. Cadaveric Dissection of Connection Between Accessory Hemiazygos Vein and Left Brachiocephalic Vein

Author

Harsimran Panesar, Meghana Singh, Quinn Adams, Michelle B. Titunick, and Anthony S. Pagano

Abstract

Purpose: The azygos system of veins has many anatomical variations that can impact mediastinal and vascular interventions. While radiological reports on these are of great clinical value, this study is among the first to present a high-quality cadaveric dissection of a rare anatomical variant to supplement previously published radiologic studies. The azygos venous system consists of the azygos vein (AV), hemiazygos vein (HAV), and the accessory hemiazygos vein (AHAV), which develop from the last portion of the posterior cardinal veins. The normal anatomical configuration includes drainage of the posterior intercostal veins, vertebral vein, esophageal veins, HAV, and AHAV to an unpaired right-side AV at the level of the 8th/9th thoracic vertebra. Methods: An adult formalin-fixed 70-year-old female Caucasian cadaver was dissected as part of a medical gross anatomy elective course. Results: Gross documentation of a direct connection of the HAV to the AHAV with the AHAV draining into the left brachiocephalic vein. Conclusion: The reported incidence of AHAV draining directly into the left brachiocephalic vein is 1-2%. It is important to note the variations of the azygos system to avoid confusion with a potential pathology such as mediastinal masses. Understanding of the rare variant reported here could be useful in prevention of iatrogenic bleeding from misplacement of venous catheters and help facilitate radiological diagnosis in the incidence of venous clot formation.

Published
2023
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10. GPR55 deficiency in B-cells promotes atherosclerosis and regulates plasma cell maturation

Author

R Guillamat-Prats, D Hering, M Rami, C Haerdtner, D Santovito, P Rinne, S Pagano, N Nicolas Vuilleumier, S Schmid, A Janjic, W Enard, C Weber, L Maegdefessel, I Hilgendorf, and S Steffens

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Atherosclerosis is a chronic and multifactorial disease accompanied by an imbalance between resolving and pro-inflammatory lipid mediators. Targeting lipid signaling might offer new therapeutical targets for improving the clinical outcome in cardiovascular disease patients. We considered lysophosphatidylinositol (LPI) and its receptor G protein-coupled receptor (GPR)55 as a potential modulator of atherosclerosis. Its role in regulating atherosclerosis and B cell function is unknown. We hypothesize that GPR55 signaling affects atherosclerosis by regulating B cell function. Atherosclerotic plaques were compared between apolipoprotein-E-deficient (ApoE−/−) and ApoE−/−Gpr55−/− mice after 4 to 16 weeks Western Diet (WD; 0.15% cholesterol; n=12–15 per group). To test the role of B cell GPR55, we generated mixed chimeras by irradiating low density lipoprotein receptor deficient (Ldlr−/−) mice and reconstituting with a mixture of μMT and wildtype or μMT and Gpr55−/− bone marrow cells. Circulating B cells were sorted and bulk RNA sequencing analysis was performed. We performed atheroma plaque characterization, qPCR and ELISA of tissue lysates and measure plasma immunoglobulins. Circulating and tissue leukocyte counts were determined. We confirmed Gpr55 expression on circulating B cells, which was higher compared to T and myeloid cells. ApoE−/−Gpr55−/− mice had significantly larger plaques after 4 & 16 weeks WD compared to ApoE−/−, with increased body weight & cholesterol levels. In addition, global Gpr55 deficiency resulted in enhanced aortic pro-inflammatory cytokine mRNA expression, a massively upregulated IgG levels and increased counts of splenic germinal center and plasma cells. ApoE−/−Gpr55−/− B-cell RNA-seq analysis showed 460 differential expressed genes compared to ApoE−/−. The main pathways affected were calcium ion transport, immunoglobulin production, T & B cell activation, and cellular response to stress. B cell specific Gpr55 deficiency blunted the metabolic effects but still translated in larger atherosclerotic plaques and elevated plasma IgG levels. Both global and B cell-restricted Gpr55 deficiency promotes atherosclerosis and is associated with a pro-inflammatory phenotype. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The authors received funds from the Deutsche Forschungsgemeinschaft (STE1053/6-1, STE1053/8-1 to S.S. and SFB1123 to S.S., C.W. and L.M.), the German Ministry of Research and Education (DZHK FKZ 81Z0600205 to S.S.) and the LMU Medical Faculty FöFoLe program (1061 to R.G.P.). I.H. is supported by the DFG (HI1573/2 and CRC1425 #422681845).

Published
2022
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14. Progress in the development of a KITWPA for the DARTWARS project

Author

M. Borghesi, C. Barone, S. Capelli, G. Carapella, A.P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, V. Granata, A. Greco, C. Guarcello, D. Labranca, A. Leo, C. Ligi, G. Maccarrone, F. Mantegazzini, B. Margesin, G. Maruccio, C. Mauro, R. Mezzena, A.G. Monteduro, A. Nucciotti, L. Oberto, L. Origo, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, A. Rettaroli, S. Rizzato, A. Vinante, M. Zannoni, Borghesi, M, Barone, C, Capelli, S, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Granata, V, Greco, A, Guarcello, C, Labranca, D, Leo, A, Ligi, C, Maccarrone, G, Mantegazzini, F, Margesin, B, Maruccio, G, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Origo, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rettaroli, A, Rizzato, S, Vinante, A, and Zannoni, M

Subjects
Superconductivity (cond-mat.supr-con), Nuclear and High Energy Physics, Quantum Physics, KITWPA, Condensed Matter - Superconductivity, Superconducting circuit, Parametric amplifier, Readout, Superconducting circuits, FOS: Physical sciences, Quantum Physics (quant-ph), Instrumentation
Abstract

DARTWARS (Detector Array Readout with Traveling Wave AmplifieRS) is a three years project that aims to develop high-performing innovative Traveling Wave Parametric Amplifiers (TWPAs) for low temperature detectors and qubit readout (C-band). The practical development follows two different promising approaches, one based on the Josephson junctions (TWJPA) and the other one based on the kinetic inductance of a high-resistivity superconductor (KITWPA). This paper presents the advancements made by the DARTWARS collaboration to produce a first working prototype of a KITWPA., 3 pages, 4 figures. Proceeding of Pisa15th Meeting conference

Published
2022

16. The nasopharynx as a window to half a billion years of evolutionary change to the upper respiratory tract

Author

Anthony S. Pagano and Samuel Márquez

Subjects
Mammals, Skull Base, Histology, Nasopharynx, Animals, Humans, Paleontology, Anatomy, Biological Evolution, Ecology, Evolution, Behavior and Systematics, Phylogeny, Biotechnology
Abstract

The nasopharynx is a region at the nexus of several vital physiological systems, including the nasal cavity, oral cavity, braincase, middle ear, and cervical vertebrae. It has undergone pronounced morphological change over the course of tetrapod, mammalian, and human evolution. However, despite its place in evolutionary history, the nasopharynx has received relatively little attention. This special issue focuses on "the evolution, development, and functional morphology of the nasopharynx and its boundaries." Topics covered here include evolutionary developmental biology (or evo-devo), nasopharyngeal adaptions in bats, the importance of the nasopharynx and adjacent structures over the course of human evolution, normal development, middle ear morphology, clinical importance, and the study of the nasopharynx throughout history. Contributions to this special issue range among reviews and syntheses, descriptive analyses, phylogenetic analysis, traditional morphometrics, three-dimensional geometric morphometrics, and computational fluid dynamics. Here, we discuss the central importance of the nasopharynx as can be seen through vertebrate paleontology and comparative morphology. It is via the composite evolutionary history of the nasopharyngeal boundaries that our origins may be better understood, starting with the derivation of the choanae from the median olfactory pit of jawless fish nearly half a billion years ago to the basicranial flexion and facial reduction that distinguish Homo sapiens from all other living mammals. Indeed, the nasopharynx must be acknowledged for its importance in the processes of encephalization and acquisition of speech that have become the hallmark of our species.

Published
2022

18. HIV co-infection augments EBV-induced tumorigenesis

Author

Christopher B, Whitehurst, Monica, Rizk, Adonay, Teklezghi, Rae Ann, Spagnuolo, Joseph S, Pagano, and Angela, Wahl

Subjects
hemic and lymphatic diseases, Article
Abstract

In most individuals, EBV maintains a life-long asymptomatic latent infection. However, EBV can induce the formation of B cell lymphomas in immune suppressed individuals including people living with HIV (PLWH). Most individuals who acquire HIV are already infected with EBV as EBV infection is primarily acquired during childhood and adolescence. Although antiretroviral therapy (ART) has substantially reduced the incidence of AIDS-associated malignancies, EBV positive PLWH are at an increased risk of developing lymphomas compared to the general population. The direct effect of HIV co-infection on EBV replication and EBV-induced tumorigenesis has not been experimentally examined. Using a humanized mouse model of EBV infection, we demonstrate that HIV co-infection enhances systemic EBV replication and immune activation. Importantly, EBV-induced tumorigenesis was augmented in EBV/HIV co-infected mice. Collectively, these results demonstrate a direct effect of HIV co-infection on EBV pathogenesis and disease progression and will facilitate future studies to address why the incidence of certain types of EBV-associated malignancies are stable or increasing in ART treated PLWH.

Published
2022

20. Industry profitability matters: The value of sustainable growth rate and distance from bankruptcy as enablers of venture survival

Author

Maria João Guedes, Michael S. Pagano, Pankaj C. Patel, and Gerard T. Olson

Subjects
Marketing, Entrepreneurship, 05 social sciences, New Ventures, Profit (economics), Bankruptcy, 0502 economics and business, Strategic fit, 050211 marketing, Profitability index, Business, Sustainable growth rate, Return on capital, 050203 business & management, Industrial organization
Abstract

Industries with a higher return on invested capital (ROIC), or profit for each unit of assets invested, could be particularly appealing to entrepreneurs. Yet, why do some ventures in industries with high ROIC survive while others do not? Drawing on the strategic fit framework, we posit that ventures with a higher sustainable growth rate (i.e., matching internal growth with industry ROIC) or stability (i.e., lower chances of bankruptcy) are more likely to survive in industries with a higher ROIC. We find support for our hypotheses in a sample of 120,816 new ventures established between 2010 and 2016 (15,236 new ventures failed during the period of observation). The findings have implications for the entrepreneurship literature related to the role of industry in explaining venture survival under varying ROIC industry conditions.

Published
2020
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21. Investigation of topological regime in Bi2Se3 thin films through low-frequency electric noise

Author

C. Barone, P. Orgiani, G. Carapella, V. Granata, S. K. Chaluvadi, and S. Pagano

Subjects
Physics and Astronomy (miscellaneous), Topological insulators, Electric noise spectroscopy, Spintronics
Abstract

Topological insulators are considered new states of quantum matter that cannot be systematically related to conventional insulators and semiconductors. Among them, Bi2Se3 has attracted an increasing interest due to a simple surface band structure and due to a strong contribution of the surface to transport. While the dc electric transport properties have been extensively studied, intrinsic fluctuations and their effect on the surface conduction have received less attention. In order to better investigate these aspects, a detailed characterization of the low-frequency noise, also known as noise spectroscopy, has been made in Bi2Se3 thin films. The experimental results have been obtained for different samples thickness and geometry, in a temperature range from 300 down to 8 K, and as a function of dc bias current and gate voltage. While the observed spectral noise shows a typical thermal and shot noise part, an unusual reduction of the 1/ f noise component is found, especially in the low-temperature region. A correlation of this behavior with structural and dc electric transport investigations suggests that it could be an indication of the occurrence of the topological regime. Flicker noise measurements, therefore, could be considered as a valid alternative technique to standard topological surface state spectroscopy.

Published
2023
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22. B cell-specific GPR55 deficiency promotes atherosclerosis

Author

R. Guillamat-Prats, D. Hering, M. Rami, C. Hädtner, D. Santovito, P. Rinne, L. Bindila, M. Hristov, S. Pagano, N. Vuilleumier, S. Schmid, A. Janjic, W. Enard, C. Weber, L. Maegdefessel, A. Faussner, I. Hilgendorf, and S. Steffens

Subjects
Cardiology and Cardiovascular Medicine
Published
2022
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24. Effect of the substrate on the electrical transport and fluctuation processes in NbRe and NbReN ultrathin films for superconducting electronics applications

Author

C. Barone, C. Cirillo, G. Carapella, V. Granata, D. Santoro, C. Attanasio, and S. Pagano

Subjects
Surfaces, Multidisciplinary, Surfaces, interfaces and thin films, Electronic properties and materials, interfaces and thin films, Science, Medicine, Superconducting properties and materials, Materials science, Article
Abstract

NbRe-based superconducting thin films recently received relevant interest in the field of low-temperature electronics. However, for these materials the electrical conduction mechanisms, in particular in the normal state, still need to be investigated in more detail. Here, NbRe and NbReN films of different thicknesses have been deposited on two different substrates, namely monocrystalline Si and $$\text {SiO}_2$$ SiO 2 buffered Si. The films were characterized by DC electrical transport measurements. Moreover, a connection with the charge carriers fluctuation processes has been made by analyzing the electrical noise generated in the normal state region. Despite the films morphology seems not to be affected by the substrate used, a lower noise level has been found for the ones grown on $$\text {SiO}_2$$ SiO 2 , in particular for NbReN. From this study it emerges that both NbRe and NbReN ultrathin films are of very good quality, as far as the low-temperature electrical noise and conduction are concerned, with noise levels competitive with NbN. These results may further support the proposal of using these materials in a nanowire form in the field of superconducting electronics.

Published
2022

25. Prompt D-0, D+, and D*(+) production in Pb-Pb collisions at root S-NN=5.02 TeV

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Ahuja, I Akbar, Z. Akindinov, A. and Al-Turany, M. Alam, S. N. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Alfaro Molina, R. Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altsybeev, I Anaam, M. N. Andrei, C. Andreou, D. and Andronic, A. Angeletti, M. Anguelov, V Antinori, F. and Antonioli, P. Anuj, C. Apadula, N. Aphecetche, L. and Appelshaeuser, H. Arcelli, S. Arnaldi, R. Arsene, I. C. and Arslandok, M. Augustinus, A. Averbeck, R. Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. Bailhache, R. and Bailung, Y. Bala, R. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Barbera, R. Barioglio, L. Barlou, M. and Barnafoldi, G. G. Barnby, L. S. Barret, V Bartels, C. and Barth, K. Bartsch, E. Baruffaldi, F. Bastid, N. Basu, S. and Batigne, G. Batyunya, B. Bauri, D. Alba, J. L. Bazo and Bearden, I. G. Beattie, C. Becht, P. Belikov, I and BellHechavarria, A. D. C. Bellini, F. Bellwied, R. and Belokurova, S. Belyaev, V Bencedi, G. Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M. G. Betev, L. Bhaduri, P. P. Bhasin, A. Bhat, I. R. and Bhat, M. A. Bhattacharjee, B. Bhattacharya, P. Bianchi, L. and Bianchi, N. Biernat, J. Bilandzic, A. Biro, G. and Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. Bok, J. and Boldizsar, L. Bolozdynya, A. Bombara, M. Bond, P. M. and Bonomi, G. Borel, H. Borissov, A. Bossi, H. Botta, E. and Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. and Bruno, G. E. Buckland, M. D. Budnikov, D. Buesching, H. and Bufalino, S. Bugnon, O. Buhler, P. Buthelezi, Z. Butt, J. B. Bylinkin, A. Bysiak, S. A. Cai, M. Caines, H. and Caliva, A. Villar, E. Calvo Camacho, J. M. M. Camacho, R. S. and Camerini, P. Canedo, F. D. M. Carnesecchi, F. Caron, R. and Castellanos, J. Castillo Casula, E. A. R. Catalano, F. and Sanchez, C. Ceballos Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. Chattopadhyay, S. Chattopadhyay, S. and Chauvin, A. Chavez, T. G. Cheng, T. Cheshkov, C. and Cheynis, B. Barroso, V. Chibante Chinellato, D. D. Cho, S. and Chochula, P. Christakoglou, P. Christensen, C. H. and Christiansen, P. Chujo, T. Cicalo, C. Cifarelli, L. and Cindolo, F. Ciupek, M. R. Clai, G. Cleymans, J. and Colamaria, F. Colburn, J. S. Colella, D. Collu, A. and Colocci, M. Concas, M. ConesaBalbastre, G. del Valle, Z. Conesa Contin, G. Contreras, J. G. Coquet, M. L. and Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. and Costanza, S. Crochet, P. Cruz-Torres, R. Cuautle, E. and Cui, P. Cunqueiro, L. Dainese, A. Danisch, M. C. Danu, A. Das, P. Das, P. Das, S. Dash, S. De Caro, A. and de Cataldo, G. DeCilladi, L. de Cuveland, J. De Falco, A. and De Gruttola, D. De Marco, N. De Martin, C. De Pasquale, S. Deb, S. Degenhardt, H. F. Deja, K. R. Dello Stritto, L. Deng, W. Dhankher, P. Di Bari, D. Di Mauro, A. and Diaz, R. A. Dietel, T. Ding, Y. Divia, R. Dixit, D. U. and Djuvsland, O. Dmitrieva, U. Do, J. Dobrin, A. and Doenigus, B. Dubey, A. K. Dubla, A. Dudi, S. Dupieux, P. and Dzalaiova, N. Eder, T. M. Ehlers, R. J. Eikeland, V. N. and Eisenhut, F. Elia, D. Erazmus, B. Ercolessi, F. and Erhardt, F. Erokhin, A. Ersdal, M. R. Espagnon, B. and Eulisse, G. Evans, D. Evdokimov, S. Fabbietti, L. and Faggin, M. Faivre, J. Fan, F. Fantoni, A. Fasel, M. and Fecchio, P. Feliciello, A. Feofilov, G. Fernandez Tellez, A. and Ferrero, A. Ferretti, A. Feuillard, V. J. G. Figiel, J. and Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. and Flor, F. Flores, A. N. Foertsch, S. Fokin, S. and Fragiacomo, E. Frajna, E. Fuchs, U. Funicello, N. and Furget, C. Furs, A. Gaardhoje, J. J. Gagliardi, M. Gago, A. M. Gal, A. Galvan, C. D. Ganoti, P. Garabatos, C. and Garcia, J. R. A. Garcia-Solis, E. Garg, K. Gargiulo, C. and Garibli, A. Garner, K. Gasik, P. Gauger, E. F. Gautam, A. Ducati, M. B. Gay Germain, M. Ghosh, P. Ghosh, S. K. and Giacalone, M. Gianotti, P. Giubellino, P. Giubilato, P. and Glaenzer, A. M. C. Glaessel, P. Goh, D. J. Q. Gonzalez, V Gonzalez-Trueba, L. H. Gorbunov, S. Gorgon, M. and Gorlich, L. Gotovac, S. Grabski, V Graczykowski, L. K. and Greiner, L. Grelli, A. Grigoras, C. Grigoriev, V and Grigoryan, S. Grosa, F. Grosse-Oetringhaus, J. F. Grosso, R. and Guardiano, G. G. Guernane, R. Guilbaud, M. Gulbrandsen, K. Gunji, T. Guo, W. Gupta, A. Gupta, R. Guzman, S. P. Gyulai, L. Habib, M. K. Hadjidakis, C. Hamagaki, H. and Hamid, M. Hannigan, R. Haque, M. R. Harlenderova, A. and Harris, J. W. Harton, A. Hasenbichler, J. A. Hassan, H. and Hatzifotiadou, D. Hauer, P. Havener, L. B. Heckel, S. T. and Hellbar, E. Helstrup, H. Herman, T. Hernandez, E. G. and Corral, G. Herrera Herrmann, F. Hetland, K. F. Hillemanns, H. Hills, C. Hippolyte, B. Hofman, B. Hohlweger, B. and Honermann, J. Hong, G. H. Horak, D. Hornung, S. Horzyk, A. Hosokawa, R. Hou, Y. Hristov, P. 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L. and Mikhaylov, K. Mishra, A. N. Modak, A. Mohanty, A. P. and Mohanty, B. Khan, M. Mohisin Molander, M. A. Moravcova, Z. and Mordasini, C. De Godoy, D. A. Moreira Morozov, I Morsch, A. Mrnjavac, T. Muccifora, V Mudnic, E. Muehlheim, D. and Muhuri, S. Mulligan, J. D. Mulliri, A. Munhoz, M. G. and Munzer, R. H. Murakami, H. Murray, S. Musa, L. Musinsky, J. Myrcha, J. W. Naik, B. Nair, R. Nandi, B. K. and Nania, R. Nappi, E. Nassirpour, A. F. Nath, A. Nattrass, C. Neagu, A. Nellen, L. Nesbo, V, S. Neskovic, G. and Nesterov, D. Nielsen, B. S. Nikolaev, S. Nikulin, S. and Nikulin, V Noferini, F. Noh, S. Nomokonov, P. Norman, J. and Novitzky, N. Nowakowski, P. Nyanin, A. Nystrand, J. and Ogino, M. Ohlson, A. Okorokov, V. A. Oleniacz, J. and DaSilva, A. C. Oliveira Oliver, M. H. Onnerstad, A. and Oppedisano, C. Ortiz Velasquez, A. Osako, T. Oskarsson, A. and Otwinowski, J. Oya, M. Oyama, K. Pachmayer, Y. and Padhan, S. Pagano, D. Palasciano, A. Pan, J. Panebianco, S. Park, J. Parkkila, J. E. Pathak, S. P. Patra, R. N. and Paul, B. Pei, H. Peitzmann, T. Peng, X. Pereira, L. G. Da Costa, H. Pereira Peresunko, D. Perez, G. M. and Perrin, S. Pestov, Y. Petrovici, M. Pezzi, R. P. Piano, S. Pikna, M. Pillot, P. Pinazza, O. Pinsky, L. and Pinto, C. Pisano, S. Planinic, M. Pliquett, F. and Poghosyan, M. G. Polichtchouk, B. Politano, S. Poljak, N. and Pop, A. Porteboeuf-Houssais, S. Porter, J. Pozdniakov, V and Prasad, S. K. Preghenella, R. Prino, F. Pruneau, C. A. and Pshenichnov, I Puccio, M. Qiu, S. Quaglia, L. and Quishpe, R. E. Ragoni, S. Rakotozafindrabe, A. Ramello, L. and Rami, F. Ramirez, S. A. R. Ramos, A. G. T. Rancien, T. A. Raniwala, R. Raniwala, S. Rasanen, S. S. Rath, R. and Ravasenga, I Read, K. F. Redelbach, A. R. Redlich, K. and Rehman, A. Reichelt, P. Reidt, F. Reme-ness, H. A. and Rescakova, Z. Reygers, K. Riabov, A. Riabov, V Richert, T. Richter, M. Riegler, W. Riggi, F. Ristea, C. and Cahuantzi, M. Rodriguez Roed, K. Rogalev, R. 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Shahoyan, R. Shaikh, W. Shangaraev, A. and Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. and Sharma, U. Sheibani, O. Shigaki, K. Shimomura, M. and Shirinkin, S. Shou, Q. Sibiriak, Y. Siddhanta, S. and Siemiarczuk, T. Silva, T. F. Silvermyr, D. Simantathammakul, T. Simonetti, G. Singh, B. Singh, R. Singh, R. and Singh, R. Singh, V. K. Singhal, V Sinha, T. Sitar, B. and Sitta, M. Skaali, T. B. Skorodumovs, G. Slupecki, M. and Smirnov, N. Snellings, R. J. M. Soncco, C. Song, J. and Songmoolnak, A. Soramel, F. Sorensen, S. Sputowska, I and Stachel, J. Stan, I Steffanic, P. J. Stiefelmaier, S. F. and Stocco, D. Storehaug, I Storetvedt, M. M. Stratmann, P. and Stylianidis, C. P. Suaide, A. A. P. Suire, C. Sukhanov, M. and Suljic, M. Sultanov, R. Sumberia, V Sumowidagdo, S. and Swain, S. Szabo, A. Szarka, I Tabassam, U. Taghavi, S. F. Taillepied, G. Takahashi, J. Tambave, G. J. Tang, S. and Tang, Z. Takaki, J. D. Tapia Tarhini, M. Tarzila, M. G. and Tauro, A. Tejeda Munoz, G. 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Wegrzynek, A. Wenzel, S. C. Wessels, J. P. Wiechula, J. Wikne, J. Wilk, G. Wilkinson, J. and Willems, G. A. Windelband, B. Winn, M. Witt, W. E. and Wright, J. R. Wu, W. Wu, Y. Xu, R. Yadav, A. K. and Yalcin, S. Yamaguchi, Y. Yamakawa, K. Yang, S. Yano, S. and Yin, Z. Yoo, I-K Yoon, J. H. Yuan, S. Yuncu, A. and Zaccolo, V Zampolli, C. Zanoli, H. J. C. Zardoshti, N. and Zarochentsev, A. Zavada, P. Zaviyalov, N. Zhalov, M. and Zhang, B. Zhang, S. Zhang, X. Zhang, Y. Zherebchevskii, V Zhi, Y. Zhigareva, N. Zhou, D. Zhou, Y. Zhu, J. and Zhu, Y. Zinovjev, G. Zurlo, N. ALICE Collaboration

Subjects
Nuclear Theory, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

The production of prompt D-0, D+, and D*(+) mesons was measured at midrapidity (vertical bar y vertical bar < 0.5) in Pb-Pb collisions at the centre-of-mass energy per nucleon-nucleon pair root S-NN = 5.02 TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decay channels and their production yields were measured in central (0-10%) and semicentral (30-50%) collisions. The measurement was performed up to a transverse momentum (p(T)) of 36 or 50 GeV/c depending on the D meson species and the centrality interval. For the first time in Pb-Pb collisions at the LHC, the yield of D-0 mesons was measured down to p(T) = 0, which allowed a model-independent determination of the p(T)-integrated yield per unit of rapidity (dN/dy). A maximum suppression by a factor 5 and 2.5 was observed with the nuclear modification factor (R-AA) of prompt D mesons at p(T) = 6-8 GeV/c for the 0-10% and 30-50% centrality classes, respectively. The D-meson R-AA is compared with that of charged pions, charged hadrons, and J/psi mesons as well as with theoretical predictions. The analysis of the agreement between the measured R-AA, elliptic (v(2)) and triangular (v(3)) flow, and the model predictions allowed us to constrain the charm spatial diffusion coefficient D-s. Furthermore the comparison of R-AA and v(2) with different implementations of the same models provides an important insight into the role of radiative energy loss as well as charm quark recombination in the hadronisation mechanisms.

Published
2022

26. HIV Co-infection Augments EBV-Induced Tumorigenesis in vivo

Author

Christopher B. Whitehurst, Monica Rizk, Adonay Teklezghi, Rae Ann Spagnuolo, Joseph S. Pagano, and Angela Wahl

Subjects
hemic and lymphatic diseases
Abstract

In most individuals, EBV maintains a life-long asymptomatic latent infection. However, EBV can induce the formation of B cell lymphomas in immune suppressed individuals including people living with HIV (PLWH). Most individuals who acquire HIV are already infected with EBV as EBV infection is primarily acquired during childhood and adolescence. Although antiretroviral therapy (ART) has substantially reduced the incidence of AIDS-associated malignancies, EBV positive PLWH are at an increased risk of developing lymphomas compared to the general population. The direct effect of HIV co-infection on EBV replication and EBV-induced tumorigenesis has not been experimentally examined. Using a humanized mouse model of EBV infection, we demonstrate that HIV co-infection enhances systemic EBV replication and immune activation. Importantly, EBV-induced tumorigenesis was augmented in EBV/HIV co-infected mice. Collectively, these results demonstrate a direct effect of HIV co-infection on EBV pathogenesis and disease progression and will facilitate future studies to address why the incidence of certain types of EBV-associated malignancies are stable or increasing in ART treated PLWH.

Published
2022
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27. Charm-quark fragmentation fractions and production cross section at mid rapidity in pp collisions at the LHC

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Ahuja, I Akbar, Z. Akindinov, A. and Al-Turany, M. Alam, S. N. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Alfaro Molina, R. Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altenkamper, L. Altsybeev, I Anaam, M. N. Andrei, C. and Andreou, D. Andronic, A. Angeletti, M. Anguelov, V and Antinori, F. Antonioli, P. Anuj, C. Apadula, N. and Aphecetche, L. Appelshaeuser, H. Arcelli, S. Arnaldi, R. and Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. and Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. and Bailhache, R. Bailung, Y. Bala, R. Balbino, A. and Baldisseri, A. Balis, B. Ball, M. Banerjee, D. Barbera, R. Barioglio, L. Barlou, M. Barnafoldi, G. G. Barnby, L. S. Barret, V Bartels, C. Barth, K. Bartsch, E. and Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. Bauri, D. Alba, J. L. Bazo Bearden, I. G. Beattie, C. and Belikov, I Hechavarria, A. D. C. Bell Bellini, F. and Bellwied, R. Belokurova, S. Belyaev, V Bencedi, G. and Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. and Berenyi, D. Bergmann, L. Besoiu, M. G. Betev, L. and Bhaduri, P. P. Bhasin, A. Bhat, M. A. Bhattacharjee, B. and Bhattacharya, P. Bianchi, L. Bianchi, N. Biernat, J. and Bilandzic, A. Biro, G. Biswas, S. Blair, J. T. Blau, D. and Blidaru, M. B. Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. Bok, J. Boldizsar, L. Bolozdynya, A. and Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Bossi, H. Botta, E. Bratrud, L. Braun-Munzinger, P. and Bregant, M. Broz, M. Bruno, G. E. Buckland, M. D. and Budnikov, D. Buesching, H. Bufalino, S. Bugnon, O. and Buhler, P. Buthelezi, Z. Butt, J. B. Bysiak, S. A. and Caffarri, D. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camacho, R. S. Camerini, P. Canedo, F. D. M. Carnesecchi, F. Caron, R. Castellanos, J. Castillo and Casula, E. A. R. Catalano, F. Sanchez, C. Ceballos and Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. and Chattopadhyay, S. Chattopadhyay, S. Chauvin, A. Chavez, T. G. Cheshkov, C. Cheynis, B. Barroso, V. Chibante and Chinellato, D. D. Cho, S. Chochula, P. Christakoglou, P. and Christensen, C. H. Christiansen, P. Chujo, T. Cicalo, C. and Cifarelli, L. Cindolo, F. Ciupek, M. R. Clai, G. and Cleymans, J. Colamaria, F. Colburn, J. S. Colella, D. and Collu, A. Colocci, M. Concas, M. Balbastre, G. Conesa and del Valle, Z. Conesa Contin, G. Contreras, J. G. Coquet, M. L. Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. and Costanza, S. Crochet, P. Cuautle, E. Cui, P. and Cunqueiro, L. Dainese, A. Damas, F. P. A. Danisch, M. C. and Danu, A. Das, I Das, P. Das, P. Das, S. Dash, S. and De, S. De Caro, A. de Cataldo, G. De Cilladi, L. de Cuveland, J. De Falco, A. De Gruttola, D. De Marco, N. and De Martin, C. De Pasquale, S. Deb, S. Degenhardt, H. F. and Deja, K. R. Dello Stritto, L. Delsanto, S. Deng, W. and Dhankher, P. Di Bari, D. Di Mauro, A. Diaz, R. A. and Dietel, T. Ding, Y. Divia, R. Djuvsland, O. Dixit, D. U. and Dmitrieva, U. Do, J. Dobrin, A. Donigus, B. Dordic, O. Dubey, A. K. Dubla, A. Dudi, S. Dukhishyam, M. and Dupieux, P. Dzalaiova, N. Eder, T. M. Ehlers, R. J. and Eikeland, V. N. Elia, D. Erazmus, B. Ercolessi, F. and Erhardt, F. Erokhin, A. Ersdal, M. R. Espagnon, B. and Eulisse, G. Evans, D. Evdokimov, S. Fabbietti, L. and Faggin, M. Faivre, J. Fan, F. Fantoni, A. Fasel, M. and Fecchio, P. Feliciello, A. Feofilov, G. Fernandez Tellez, A. and Ferrero, A. Ferretti, A. Feuillard, V. J. G. Figiel, J. and Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. and Flor, F. Flores, A. N. Foertsch, S. Foka, P. Fokin, S. Fragiacomo, E. Frajna, E. Fuchs, U. Funicello, N. and Furget, C. Furs, A. Gaardhoje, J. J. Gagliardi, M. Gago, A. M. Gal, A. Galvan, C. D. Ganoti, P. Garabatos, C. and Garcia, J. R. A. Garcia-Solis, E. Garg, K. Gargiulo, C. and Garibli, A. Garner, K. Gasik, P. Gauger, E. F. Gautam, A. Ducati, M. B. Gay Germain, M. Ghosh, J. Ghosh, P. and Ghosh, S. K. Giacalone, M. Gianotti, P. Giubellino, P. and Giubilato, P. Glaenzer, A. M. C. Glassel, P. Goh, D. J. Q. and Gonzalez, V Gonzalez-Trueba, L. H. Gorbunov, S. Gorgon, M. Gorlich, L. Gotovac, S. Grabski, V Graczykowski, L. K. Greiner, L. Grelli, A. Grigoras, C. Grigoriev, V and Grigoryan, A. Grigoryan, S. Groettvik, O. S. Grosa, F. and Grosse-Oetringhaus, J. F. Grosso, R. Guardiano, G. G. and Guernane, R. Guilbaud, M. Gulbrandsen, K. Gunji, T. and Gupta, A. Gupta, R. Guzman, S. P. Gyulai, L. Habib, M. K. Hadjidakis, C. Halimoglu, G. Hamagaki, H. Hamar, G. and Hamid, M. Hannigan, R. Haque, M. R. Harlenderova, A. and Harris, J. W. Harton, A. Hasenbichler, J. A. Hassan, H. and Hatzifotiadou, D. Hauer, P. Havener, L. B. Hayashi, S. and Heckel, S. T. Hellbar, E. Helstrup, H. Herman, T. and Hernandez, E. G. Herrera Corral, G. Herrmann, F. Hetland, K. F. Hillemanns, H. Hills, C. Hippolyte, B. Hofman, B. and Hohlweger, B. Honermann, J. Hong, G. H. Horak, D. and Hornung, S. Horzyk, A. Hosokawa, R. Hristov, P. Huang, C. Hughes, C. Huhn, P. Humanic, T. J. Hushnud, H. and Husova, L. A. Hutson, A. Hutter, D. Iddon, J. P. Ilkaev, R. Ilyas, H. Inaba, M. Innocenti, G. M. Ippolitov, M. and Isakov, A. Islam, M. S. Ivanov, M. Ivanov, V and Izucheev, V Jablonski, M. Jacak, B. Jacazio, N. Jacobs, P. M. Jadlovska, S. Jadlovsky, J. Jaelani, S. Jahnke, C. and Jakubowska, M. J. Jalotra, A. Janik, M. A. Janson, T. and Jercic, M. Jevons, O. Jonas, F. Jones, P. G. Jowett, J. M. Jung, J. Jung, M. Junique, A. Jusko, A. and Kaewjai, J. Kalinak, P. Kalweit, A. Kaplin, V Kar, S. and Uysal, A. Karasu Karatovic, D. Karavichev, O. and Karavicheva, T. Karczmarczyk, P. Karpechev, E. Kazantsev, A. and Kebschull, U. Keidel, R. Keijdener, D. L. D. Keil, M. and Ketzer, B. Khabanova, Z. Khan, A. M. Khan, S. and Khanzadeev, A. Kharlov, Y. Khatun, A. Khuntia, A. and Kileng, B. Kim, B. Kim, C. Kim, D. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, J. Kim, J. Kim, J. and Kim, M. Kim, S. Kim, T. Kirsch, S. Kisel, I Kiselev, S. Kisiel, A. Kitowski, J. P. Klay, J. L. Klein, J. and Klein, S. Klein-Bosing, C. Kleiner, M. Klemenz, T. and Kluge, A. Knospe, A. G. Kobdaj, C. Kohler, M. K. and Kollegger, T. Kondratyev, A. Kondratyeva, N. Kondratyuk, E. and Konig, J. Konigstorfer, S. A. Konopka, P. J. Kornakov, G. Koryciak, S. D. Koska, L. Kotliarov, A. Kovalenko, O. and Kovalenko, V Kowalski, M. Kralik, I Kreis, L. and Krivda, M. Krizek, F. Gajdosova, K. Krizkova Kroesen, M. and Kruger, M. Kryshen, E. Krzewicki, M. Kuhn, C. Kuijer, P. G. Kumaoka, T. Kumar, D. Kumar, L. Kumar, N. Kundu, S. Kurashvili, P. Kurepin, A. Kurepin, A. B. Kuryakin, A. Kushpil, S. Kvapil, J. Kweon, M. J. Kwon, J. Y. and Kwon, Y. La Pointe, S. L. La Rocca, P. Lai, Y. S. and Lakrathok, A. Lamanna, M. Langoy, R. Lapidus, K. and Larionov, P. Laudi, E. Lautner, L. Lavicka, R. Lazareva, T. Lea, R. Lehrbach, J. Lemmon, R. C. Monzon, I. Leon and Lesser, E. D. Lettrich, M. Levai, P. Li, X. Li, X. L. Lien, J. Lietava, R. Lim, B. Lim, S. H. and Lindenstruth, V Lindner, A. Lippmann, C. Liu, A. Liu, J. and Lofnes, I. M. Loginov, V Loizides, C. Loncar, P. and Lopez, J. A. Lopez, X. Lopez Torres, E. Luhder, J. R. and Lunardon, M. Luparello, G. Ma, Y. G. Maevskaya, A. and Mager, M. Mahmoud, T. Maire, A. Malaev, M. Malik, N. M. and Malik, Q. W. Malinina, L. Mal'Kevich, D. Mallick, N. and Malzacher, P. Mandaglio, G. Manko, V Manso, F. Manzari, V Mao, Y. Mares, J. Margagliotti, V, G. Margotti, A. and Marin, A. Markert, C. Marquard, M. Martin, N. A. and Martinengo, P. Martinez, J. L. Martinez, I, M. Garcia, G. Martinez Masciocchi, S. Masera, M. Masoni, A. and Massacrier, L. Mastroserio, A. Mathis, A. M. Matonoha, O. and Matuoka, P. F. T. Matyja, A. Mayer, C. Mazuecos, A. L. and Mazzaschi, F. Mazzilli, M. Mazzoni, M. A. Mdhluli, J. E. and Mechler, A. F. Meddi, F. Melikyan, Y. Menchaca-Rocha, A. and Meninno, E. Menon, A. S. Meres, M. Mhlanga, S. and Miake, Y. Micheletti, L. Migliorin, L. C. Mihaylov, D. L. and Mikhaylov, K. Mishra, A. N. Modak, A. Mohanty, A. P. and Mohanty, B. Khan, M. Mohisin Moravcova, Z. Mordasini, C. and De Godoy, D. A. Moreira Moreno, L. A. P. Morozov, I Morsch, A. Mrnjavac, T. Muccifora, V Mudnic, E. Muhlheim, D. and Muhuri, S. Mulligan, J. D. Mulliri, A. Munhoz, M. G. and Munzer, R. H. Murakami, H. Murray, S. Musa, L. Musinsky, J. Myrcha, J. W. Naik, B. Nair, R. Nandi, B. K. and Nania, R. Nappi, E. Naru, M. U. Nassirpour, A. F. Nath, A. Nattrass, C. Neagu, A. Nellen, L. Nesbo, V, S. and Neskovic, G. Nesterov, D. Nielsen, B. S. Nikolaev, S. and Nikulin, S. Nikulin, V Noferini, F. Noh, S. Nomokonov, P. Norman, J. Novitzky, N. Nowakowski, P. Nyanin, A. and Nystrand, J. Ogino, M. Ohlson, A. Okorokov, V. A. and Oleniacz, J. Da Silva, A. C. Oliveira Oliver, M. H. and Onnerstad, A. Oppedisano, C. Velasquez, A. Ortiz Osako, T. and Oskarsson, A. Otwinowski, J. Oyama, K. Pachmayer, Y. and Padhan, S. Pagano, D. Palasciano, A. Pan, J. Panebianco, S. Pareek, P. Park, J. Parkkila, J. E. Pathak, S. P. and Patra, R. N. Paul, B. Pazzini, J. Pei, H. Peitzmann, T. and Peng, X. Pereira, L. G. Da Costa, H. Pereira Peresunko, D. Perez, G. M. Perrin, S. Pestov, Y. Petrovici, M. and Pezzi, R. P. Piano, S. Pikna, M. Pillot, P. Pinazza, O. and Pinsky, L. Pinto, C. Pisano, S. Planinic, M. and Pliquett, F. Poghosyan, M. G. Polichtchouk, B. Politano, S. and Poljak, N. Pop, A. Porteboeuf-Houssais, S. Porter, J. and Pozdniakov, V Prasad, S. K. Preghenella, R. Prino, F. and Pruneau, C. A. Pshenichnov, I Puccio, M. Qiu, S. and Quaglia, L. Quishpe, R. E. Ragoni, S. Rakotozafindrabe, A. and Ramello, L. Rami, F. Ramirez, S. A. R. Ramos, A. G. T. and Rancien, T. A. Raniwala, R. Raniwala, S. Rasanen, S. S. and Rath, R. Ravasenga, I Read, K. F. Redelbach, A. R. and Redlich, K. Rehman, A. Reichelt, P. Reidt, F. Reme-ness, H. A. Renfordt, R. Rescakova, Z. Reygers, K. Riabov, A. and Riabov, V Richert, T. Richter, M. Riegler, W. Riggi, F. Ristea, C. Rode, S. P. Rodriguez Cahuantzi, M. Roed, K. Rogalev, R. Rogochaya, E. Rogoschinski, T. S. Rohr, D. Rohrich, D. Rojas, P. F. Rokita, P. S. Ronchetti, F. and Rosano, A. Rosas, E. D. Rossi, A. Rotondi, A. Roy, A. Roy, P. Roy, S. Rubini, N. Rueda, V, O. Rui, R. and Rumyantsev, B. Russek, P. G. Rustamov, A. Ryabinkin, E. and Ryabov, Y. Rybicki, A. Rytkonen, H. Rzesa, W. and Saarimaki, O. A. M. Sadek, R. Sadovsky, S. Saetre, J. and Saha, S. K. Saha, S. Sahoo, B. Sahoo, P. Sahoo, R. and Sahoo, S. Sahu, D. Sahu, P. K. Saini, J. Sakai, S. and Sambyal, S. Samsonov, V Sarkar, D. Sarkar, N. Sarma, P. and Sarti, V. M. Sas, M. H. P. Schambach, J. Scheid, H. S. and Schiaua, C. Schicker, R. Schmah, A. Schmidt, C. and Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, V, N. and Schmier, A. R. Schotter, R. Schukraft, J. Schutz, Y. and Schwarz, K. Schweda, K. Scioli, G. Scomparin, E. Seger, J. E. Sekiguchi, Y. Sekihata, D. Selyuzhenkov, I and Senyukov, S. Seo, J. J. Serebryakov, D. Sevcenco, A. and Shaba, T. J. Shabanov, A. Shabetai, A. Shahoyan, R. and Shaikh, W. Shangaraev, A. Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sheibani, O. and Shigaki, K. Shimomura, M. Shirinkin, S. Shou, Q. and Sibiriak, Y. Siddhanta, S. Siemiarczuk, T. Silva, T. F. and Silvermyr, D. Simonetti, G. Singh, B. Singh, R. Singh, R. Singh, R. Singh, V. K. Singhal, V Sinha, T. and Sitar, B. Sitta, M. Skaali, T. B. Skorodumovs, G. and Slupecki, M. Smirnov, N. Snellings, R. J. M. Soncco, C. and Song, J. Songmoolnak, A. Soramel, F. Sorensen, S. and Sputowska, I Stachel, J. Stan, I Steffanic, P. J. and Stiefelmaier, S. F. Stocco, D. Storehaug, I Storetvedt, M. M. Stylianidis, C. P. Suaide, A. A. P. Sugitate, T. and Suire, C. Suljic, M. Sultanov, R. Sumbera, M. Sumberia, V Sumowidagdo, S. Swain, S. Szabo, A. Szarka, I and Tabassam, U. Taghavi, S. F. Taillepied, G. Takahashi, J. and Tambave, G. J. Tang, S. Tang, Z. Tarhini, M. Tarzila, M. G. Tauro, A. Tejeda Munoz, G. Telesca, A. Terlizzi, L. and Terrevoli, C. Tersimonov, G. Thakur, S. Thomas, D. and Tieulent, R. Tikhonov, A. Timmins, A. R. Tkacik, M. and Toia, A. Topilskaya, N. Toppi, M. Torales-Acosta, F. and Tork, T. Torres, R. C. Torres, S. R. Trifiro, A. and Tripathy, S. Tripathy, T. Trogolo, S. Trombetta, G. and Trubnikov, V Trzaska, W. H. Trzcinski, T. P. Trzeciak, B. A. and Tumkin, A. Turrisi, R. Tveter, T. S. Ullaland, K. and Uras, A. Urioni, M. Usai, G. L. Vala, M. Valle, N. and Vallero, S. van der Kolk, N. van Doremalen, L. V. R. van Leeuwen, M. Vande Vyvre, P. Varga, D. Varga, Z. and Varga-Kofarago, M. Vargas, A. Vasileiou, M. Vasiliev, A. and Doce, O. Vazquez Vechernin, V. Vercellin, E. Vergara Limon, S. Vermunt, L. Vertesi, R. Verweij, M. Vickovic, L. and Vilakazi, Z. Baillie, O. Villalobos Vino, G. Vinogradov, A. and Virgili, T. Vislavicius, V. Vodopyanov, A. Volkel, B. and Volkl, M. A. Voloshin, K. Voloshin, S. A. Volpe, G. and von Haller, B. Vorobyev, I Voscek, D. Vozniuk, N. and Vrlakova, J. Wagner, B. Wang, C. Wang, D. Weber, M. and Weelden, V, R. J. G. Wegrzynek, A. Wenzel, S. C. Wessels, J. P. Wiechula, J. Wikne, J. Wilk, G. Wilkinson, J. and Willems, G. A. Windelband, B. Winn, M. Witt, W. E. and Wright, J. R. Wu, W. Wu, Y. Xu, R. Yalcin, S. and Yamaguchi, Y. Yamakawa, K. Yang, S. Yano, S. Yin, Z. and Yokoyama, H. Yoo, I-K Yoon, J. H. Yuan, S. Yuncu, A. and Zaccolo, V Zaman, A. Zampolli, C. Zanoli, H. J. C. and Zardoshti, N. Zarochentsev, A. Zavada, P. Zaviyalov, N. and Zbroszczyk, H. Zhalov, M. Zhang, S. Zhang, X. Zhang, Y. and Zherebchevskii, V Zhi, Y. Zhou, D. Zhou, Y. Zhu, J. and Zhu, Y. Zichichi, A. Zinovjev, G. Zurlo, N. ALICE Collaboration

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Recent p(T)-integrated cross-section measurements of the ground-state charm mesons and baryons, D-0, D+, D-s(+), Lambda(+)(c), and Xi(0)(c) are used to evaluate the charm fragmentation fractions and production cross section per unit of rapidity at midrapidity (vertical bar y vertical bar < 0.5), in pp collisions at root s = 5.02 TeV at the LHC. The latter is d sigma(c)/dy vertical bar(vertical bar y vertical bar

Published
2022

29. xAn Overview on the Kinematic Analysis of the Rocker-Bogie Suspension

Author

102. A. Nicolella, V. Niola, S. Pagano, S. Savino, M. Spirto, Nicolella, 102. A., Niola, V., Pagano, S., Savino, S., and Spirto, M.

Subjects
Rover · Articulated suspensions · Rocker-bogie · Ground obstacles
Abstract

Articulated rocker-bogie suspension systems have gained a lot of attention since they were used for rovers destined for space exploration on Mars. This type of suspension allows the vertical load to be distributed equally between the wheels, reducing the risk of the most loaded wheels sinking in the case of soft ground. This peculiarity is verified if the rover moves on flat and horizontal surfaces; if the rover moves on uneven surfaces, the suspension still allows the wheels to be kept in contact with the ground, but the load distribution changes. This paper presents the study of the variation in the distribution of the load among the wheels and the rover stability for different ground geometries; the study involves a preventive kinematic analysis of position to define the configuration of the suspension as a function of the ground geometry.

Published
2022

32. Detector Array Readout with Traveling Wave Amplifiers

Author

A. Giachero, C. Barone, M. Borghesi, G. Carapella, A. P. Caricato, I. Carusotto, W. Chang, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, D. Giubertoni, A. Greco, C. Kutlu, A. Leo, C. Ligi, G. Maccarrone, B. Margesin, G. Maruccio, A. Matlashov, C. Mauro, R. Mezzena, A. G. Monteduro, A. Nucciotti, L. Oberto, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, S. Rizzato, Y. K. Semertzidis, S. Uchaikin, A. Vinante, Giachero, A., Barone, C., Borghesi, M., Carapella, G., Caricato, A. P., Carusotto, I., Chang, W., Cian, A., Di Gioacchino, D., Enrico, E., Falferi, P., Fasolo, L., Faverzani, M., Ferri, E., Filatrella, G., Gatti, C., Giubertoni, D., Greco, A., Kutlu, C., Leo, A., Ligi, C., Maccarrone, G., Margesin, B., Maruccio, Giuseppe, Matlashov, A., Mauro, C., Mezzena, R., Monteduro, A. G., Nucciotti, A., Oberto, L., Pagano, S., Pierro, V., Piersanti, L., Rajteri, M., Rizzato, S., Semertzidis, Y. K., Uchaikin, S., Vinante, A., Giachero, A, Barone, C, Borghesi, M, Carapella, G, Caricato, A, Carusotto, I, Chang, W, Cian, A, Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giubertoni, D, Greco, A, Kutlu, C, Leo, A, Ligi, C, Maccarrone, G, Margesin, B, Maruccio, G, Matlashov, A, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Semertzidis, Y, Uchaikin, S, and Vinante, A

Subjects
Quantum Physics, Quantum noise, Parametric amplifer, Traveling wave, Detector array read out, Qubits read out, Physics::Instrumentation and Detectors, Condensed Matter - Superconductivity, FOS: Physical sciences, Condensed Matter Physics, Parametric amplifier, Atomic and Molecular Physics, and Optics, Superconductivity (cond-mat.supr-con), General Materials Science, Quantum Physics (quant-ph), FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract

Reducing noise to the quantum limit over a large bandwidth is a fundamental requirement for future applications operating at millikelvin temperatures, such as the neutrino mass measurement, the next-generation X-ray observatory, the CMB measurement, the dark matter and axion detection, and the rapid high-fidelity readout of superconducting qubits. The read out sensitivity of arrays of microcalorimeter detectors, resonant axion-detectors, and qubits, is currently limited by the noise temperature and bandwidth of the cryogenic amplifiers. The Detector Array Readout with Traveling Wave Amplifiers project has the goal of developing high-performing innovative traveling wave parametric amplifiers with a high gain, a high saturation power, and a quantum-limited or nearly quantum-limited noise. The practical development follows two different promising approaches, one based on the Josephson junctions and the other one based on the kinetic inductance of a high-resistivity superconductor. In this contribution, we present the aims of the project, the adopted design solutions and preliminary results from simulations and measurements.

Published
2022

33. Production of light (anti)nuclei in pp collisions at root s=13 TeV

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Ahuja, I Akbar, Z. Akindinov, A. and Al-Turany, M. Alam, S. N. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Molina, R. Alfaro Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altenkamper, L. Altsybeev, I Anaam, M. N. Andrei, C. and Andreou, D. Andronic, A. Angeletti, M. Anguelov, V and Antinori, F. Antonioli, P. Anuj, C. Apadula, N. and Aphecetche, L. Appelshaeuser, H. Arcelli, S. Arnaldi, R. and Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. and Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. and Bailhache, R. Bailung, Y. Bala, R. Balbino, A. and Baldisseri, A. Balis, B. Banerjee, D. Barbera, R. and Barioglio, L. Barlou, M. Barnafoldi, G. G. Barnby, L. S. and Barret, V Bartels, C. Barth, K. Bartsch, E. Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. and Bauri, D. Alba, J. L. Bazo Bearden, I. G. Beattie, C. and Belikov, I Hechavarria, A. D. C. Bell Bellini, F. Bellwied, R. Belokurova, S. Belyaev, V Bencedi, G. Beole, S. and Bercuci, A. Berdnikov, Y. Berdnikova, A. Bergmann, L. and Besoiu, M. G. Betev, L. Bhaduri, P. P. Bhasin, A. Bhat, I. R. Bhat, M. A. Bhattacharjee, B. Bhattacharya, P. and Bianchi, L. Bianchi, N. Bielcik, J. Bielcikova, J. and Biernat, J. Bilandzic, A. Biro, G. Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. Bok, J. Boldizsar, L. and Bolozdynya, A. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Bossi, H. Botta, E. Bratrud, L. and Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G. E. and Buckland, M. D. Budnikov, D. Buesching, H. Bufalino, S. and Bugnon, O. Buhler, P. Buthelezi, Z. Butt, J. B. and Bylinkin, A. Bysiak, S. A. Cai, M. Caines, H. Caliva, A. and Calvo Villar, E. Camacho, J. M. M. Camacho, R. S. and Camerini, P. Canedo, F. D. M. Carnesecchi, F. Caron, R. and Castellanos, J. Castillo Casula, E. A. R. Catalano, F. and Sanchez, C. Ceballos Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. Chattopadhyay, S. Chauvin, A. Chavez, T. G. Cheng, T. Cheshkov, C. Cheynis, B. Barroso, V. Chibante Chinellato, D. D. Cho, S. Chochula, P. and Christakoglou, P. Christensen, C. H. Christiansen, P. Chujo, T. Cicalo, C. Cifarelli, L. Cindolo, F. Ciupek, M. R. and Clai, G. Cleymans, J. Colamaria, F. Colburn, J. S. and Colella, D. Collu, A. Colocci, M. Concas, M. Balbastre, G. Conesa del Valle, Z. Conesa Contin, G. Contreras, J. G. and Coquet, M. L. Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. Costanza, S. Crochet, P. Cruz-Torres, R. and Cuautle, E. Cui, P. Cunqueiro, L. Dainese, A. and Danisch, M. C. Danu, A. Das, I Das, P. Das, S. Dash, S. De, S. De Caro, A. de Cataldo, G. De Cilladi, L. and de Cuveland, J. De Falco, A. De Gruttola, D. De Marco, N. and De Martin, C. De Pasquale, S. Deb, S. Degenhardt, H. F. and Deja, K. R. Dello Stritto, L. Deng, W. Dhankher, P. and Di Bari, D. Di Mauro, A. Diaz, R. A. Dietel, T. Ding, Y. and Divia, R. Dixit, D. U. Djuvsland, O. Dmitrieva, U. and Do, J. Dobrin, A. Doenigus, B. Dordic, O. Dubey, A. K. and Dubla, A. Dudi, S. Dukhishyam, M. Dupieux, P. and Dzalaiova, N. Eder, T. M. Ehlers, R. J. Eikeland, V. N. and Eisenhut, F. Elia, D. Erazmus, B. Ercolessi, F. Erhardt, F. Erokhin, A. Ersdal, M. R. Espagnon, B. Eulisse, G. and Evans, D. Evdokimov, S. Fabbietti, L. Faggin, M. and Faivre, J. Fan, F. Fantoni, A. Fasel, M. Fecchio, P. and Feliciello, A. Feofilov, G. Fernandez Tellez, A. Ferrero, A. and Ferretti, A. Feuillard, V. J. G. Figiel, J. Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. Flor, F. and Flores, A. N. Foertsch, S. Foka, P. Fokin, S. and Fragiacomo, E. Frajna, E. Fuchs, U. Funicello, N. and Furget, C. Furs, A. GaardhOje, J. J. Gagliardi, M. Gago, A. M. Gal, A. Galvan, C. D. Ganoti, P. Garabatos, C. and Garcia, J. R. A. Garcia-Solis, E. Garg, K. Gargiulo, C. and Garibli, A. Garner, K. Gasik, P. Gauger, E. F. Gautam, A. Ducati, M. B. Gay Germain, M. Ghosh, P. Ghosh, S. K. and Giacalone, M. Gianotti, P. Giubellino, P. Giubilato, P. and Glaenzer, A. M. C. Glassel, P. Goh, D. J. Q. Gonzalez, V and Gonzalez-Trueba, L. H. Gorbunov, S. Gorgon, M. Gorlich, L. Gotovac, S. Grabski, V Graczykowski, L. K. Greiner, L. Grelli, A. Grigoras, C. Grigoriev, V Grigoryan, S. and Grosa, F. Grosse-Oetringhaus, J. F. Grosso, R. and Guardiano, G. G. Guernane, R. Guilbaud, M. Gulbrandsen, K. and Gunji, T. Guo, W. Gupta, A. Gupta, R. Guzman, S. P. and Gyulai, L. Habib, M. K. Hadjidakis, C. Halimoglu, G. and Hamagaki, H. Hamid, M. Hannigan, R. Haque, M. R. and Harlenderova, A. Harris, J. W. Harton, A. Hasenbichler, J. A. Hassan, H. Hatzifotiadou, D. Hauer, P. Havener, L. B. and Heckel, S. T. Hellbaer, E. Helstrup, H. Herman, T. and Hernandez, E. G. Herrera Corral, G. Herrmann, F. Hetland, K. F. Hillemanns, H. Hills, C. Hippolyte, B. Hofman, B. and Hohlweger, B. Honermann, J. Hong, G. H. Horak, D. and Hornung, S. Horzyk, A. Hosokawa, R. Hou, Y. Hristov, P. and Hughes, C. Huhn, P. Huhta, L. M. Humanic, T. J. and Hushnud, H. Husova, L. A. Hutson, A. Hutter, D. Iddon, J. P. Ilkaev, R. Ilyas, H. Inaba, M. Innocenti, G. M. and Ippolitov, M. Isakov, A. Islam, M. S. Ivanov, M. and Ivanov, V Izucheev, V Jablonski, M. Jacak, B. Jacazio, N. Jacobs, P. M. Jadlovska, S. Jadlovsky, J. Jaelani, S. and Jahnke, C. Jakubowska, M. J. Jalotra, A. Janik, M. A. and Janson, T. Jercic, M. Jevons, O. Jimenez, A. A. P. and Jonas, F. Jones, P. G. Jowett, J. M. Jung, J. Jung, M. and Junique, A. Jusko, A. Kaewjai, J. Kalinak, P. and Kalteyer, A. S. Kalweit, A. Kaplin, V Uysal, A. Karasu and Karatovic, D. Karavichev, O. Karavicheva, T. Karczmarczyk, P. Karpechev, E. Kazantsev, A. Kebschull, U. Keidel, R. and Keijdener, D. L. D. Keil, M. Ketzer, B. Khabanova, Z. and Khan, A. M. Khan, S. Khanzadeev, A. Kharlov, Y. and Khatun, A. Khuntia, A. Kileng, B. Kim, B. Kim, C. and Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. and Kim, S. Kim, T. Kirsch, S. Kisel, I Kiselev, S. and Kisiel, A. Kitowski, J. P. Klay, J. L. Klein, J. Klein, S. Klein-Boesing, C. Kleiner, M. Klemenz, T. Kluge, A. and Knospe, A. G. Kobdaj, C. Koehler, M. K. Kollegger, T. and Kondratyev, A. Kondratyeva, N. Kondratyuk, E. Konig, J. and Konigstorfer, S. A. Konopka, P. J. Kornakov, G. and Koryciak, S. D. Kotliarov, A. Kovalenko, O. Kovalenko, V and Kowalski, M. Kralik, I Kravcakova, A. Kreis, L. Krivda, M. Krizek, F. Gajdosova, K. Krizkova Kroesen, M. and Krueger, M. Kryshen, E. Krzewicki, M. Kucera, V Kuhn, C. and Kuijer, P. G. Kumaoka, T. Kumar, D. Kumar, L. Kumar, N. Kundu, S. Kurashvili, P. Kurepin, A. Kurepin, A. B. and Kuryakin, A. Kushpil, S. Kvapil, J. Kweon, M. J. and Kwon, J. Y. Kwon, Y. La Pointe, S. L. La Rocca, P. Lai, Y. S. Lakrathok, A. Lamanna, M. Langoy, R. Lapidus, K. and Larionov, P. Laudi, E. Lautner, L. Lavicka, R. and Lazareva, T. Lea, R. Lehrbach, J. Lemmon, R. C. Leon Monzon, I Lesser, E. D. Lettrich, M. Levai, P. Li, X. and Li, X. L. Lien, J. Lietava, R. Lim, B. Lim, S. H. and Lindenstruth, V Lindner, A. Lippmann, C. Liu, A. and Liu, D. H. Liu, J. Lofnes, I. M. Loginov, V Loizides, C. and Loncar, P. Lopez, J. A. Lopez, X. Torres, E. Lopez and Luhder, J. R. Lunardon, M. Luparello, G. Ma, Y. G. and Maevskaya, A. Mager, M. Mahmoud, T. Maire, A. Malaev, M. and Malik, N. M. Malik, Q. W. Malik, S. K. Malinina, L. and Mal'Kevich, D. Mallick, N. Malzacher, P. Mandaglio, G. and Manko, V Manso, F. Manzari, V Mao, Y. Mares, J. and Margagliotti, V, G. Margotti, A. Marin, A. Markert, C. and Marquard, M. Martin, N. A. Martinengo, P. Martinez, J. L. and Martinez, I, M. Garcia, G. Martinez Masciocchi, S. and Masera, M. Masoni, A. Massacrier, L. Mastroserio, A. and Mathis, A. M. Matonoha, O. Matuoka, P. F. T. Matyja, A. and Mayer, C. Mazuecos, A. L. Mazzaschi, F. Mazzilli, M. and Mazzoni, I, M. A. Mdhluli, J. E. Mechler, A. F. Meddi, F. and Melikyan, Y. Menchaca-Rocha, A. Meninno, E. Menon, A. S. and Meres, M. Mhlanga, S. Miake, Y. Micheletti, L. and Migliorin, L. C. Mihaylov, D. L. Mikhaylov, K. Mishra, A. N. and Modak, A. Mohanty, A. P. Mohanty, B. Khan, M. Mohisin and Molander, M. A. Moravcova, Z. Mordasini, C. De Godoy, D. A. Moreira Morozov, I Morsch, A. Mrnjavac, T. Muccifora, V Mudnic, E. Mughal, B. J. Muehlheim, D. Muhuri, S. and Mulligan, J. D. Mulliri, A. Munhoz, M. G. Munzer, R. H. and Murakami, H. Murray, S. Musa, L. Musinsky, J. Myrcha, J. W. Naik, B. Nair, R. Nandi, B. K. Nania, R. Nappi, E. Nassirpour, A. F. Nath, A. Nattrass, C. Neagu, A. and Nellen, L. Nesbo, V, S. Neskovic, G. Nesterov, D. and Nielsen, B. S. Nikolaev, S. Nikulin, S. Nikulin, V and Noferini, F. Noh, S. Nomokonov, P. Norman, J. Novitzky, N. Nowakowski, P. Nyanin, A. Nystrand, J. Ogino, M. and Ohlson, A. Okorokov, V. A. Oleniacz, J. Da Silva, A. C. Oliveira Oliver, M. H. Onnerstad, A. Oppedisano, C. and Velasquez, A. Ortiz Osako, T. Oskarsson, A. Otwinowski, J. and Oya, M. Oyama, K. Pachmayer, Y. Padhan, S. Pagano, D. Palasciano, A. Pan, J. Panebianco, S. Pareek, P. and Park, J. Parkkila, J. E. Pathak, S. P. Patra, R. N. and Paul, B. Pei, H. Peitzmann, T. Peng, X. Pereira, L. G. and Da Costa, H. Pereira Peresunko, D. Perez, G. M. Perrin, S. Pestov, Y. Petracek, V Petrovici, M. Pezzi, R. P. and Piano, S. Pikna, M. Pillot, P. Pinazza, O. Pinsky, L. and Pinto, C. Pisano, S. Ploskon, M. Planinic, M. and Pliquett, F. Poghosyan, M. G. Polichtchouk, B. Politano, S. and Poljak, N. Pop, A. Porteboeuf-Houssais, S. Porter, J. and Pozdniakov, V Prasad, S. K. Preghenella, R. Prino, F. and Pruneau, C. A. Pshenichnov, I Puccio, M. Qiu, S. and Quaglia, L. Quishpe, R. E. Ragoni, S. Rakotozafindrabe, A. and Ramello, L. Rami, F. Ramirez, S. A. R. Ramos, A. G. T. and Rancien, T. A. Raniwala, R. Raniwala, S. Rasanen, S. S. and Rath, R. Ravasenga, I Read, K. F. Redelbach, A. R. and Redlich, K. Rehman, A. Reichelt, P. Reidt, F. Reme-ness, H. A. Renfordt, R. Rescakova, Z. Reygers, K. Riabov, A. and Riabov, V Richert, T. Richter, M. Riegler, W. Riggi, F. Ristea, C. Rodriguez Cahuantzi, M. Roed, K. Rogalev, R. Rogochaya, E. Rogoschinski, T. S. Rohr, D. Rohrich, D. Rojas, P. F. Rokita, P. S. Ronchetti, F. Rosano, A. and Rosas, E. D. Rossi, A. Rotondi, A. Roy, A. Roy, P. and Roy, S. Rubini, N. Rueda, V, O. Ruggiano, D. Rui, R. and Rumyantsev, B. Russek, P. G. Russo, R. Rustamov, A. and Ryabinkin, E. Ryabov, Y. Rybicki, A. Rytkonen, H. Rzesa, W. Saarimaki, O. A. M. Sadek, R. Sadovsky, S. Saetre, J. and Safarik, K. Saha, S. K. Saha, S. Sahoo, B. Sahoo, P. and Sahoo, R. Sahoo, S. Sahu, D. Sahu, P. K. Saini, J. and Sakai, S. Salvan, M. P. Sambyal, S. Samsonov, V and Sarkar, D. Sarkar, N. Sarma, P. Sarti, V. M. Sas, M. H. P. Schambach, J. Scheid, H. S. Schiaua, C. Schicker, R. and Schmah, A. Schmidt, C. Schmidt, H. R. Schmidt, M. O. and Schmidt, M. Schmidt, V, N. Schmier, A. R. Schotter, R. and Schukraft, J. Schwarz, K. Schweda, K. Scioli, G. and Scomparin, E. Seger, J. E. Sekiguchi, Y. Sekihata, D. and Selyuzhenkov, I Senyukov, S. Seo, J. J. Serebryakov, D. and Serksnyte, L. Sevcenco, A. Shaba, T. J. Shabanov, A. and Shabetai, A. Shahoyan, R. Shaikh, W. Shangaraev, A. and Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. and Sharma, U. Sheibani, O. Shigaki, K. Shimomura, M. and Shirinkin, S. Shou, Q. Sibiriak, Y. Siddhanta, S. and Siemiarczuk, T. Silva, T. F. Silvermyr, D. Simantathammakul, T. Simonetti, G. Singh, B. Singh, R. Singh, V. K. and Singhal, V Sinha, T. Sitar, B. Sitta, M. Skaali, T. B. and Skorodumovs, G. Slupecki, M. Smirnov, N. Snellings, R. J. M. Soncco, C. Song, J. Songmoolnak, A. Soramel, F. and Sorensen, S. Sputowska, I Stachel, J. Stan, I and Steffanic, P. J. Stiefelmaier, S. F. Stocco, D. Storehaug, I and Storetvedt, M. M. Stratmann, P. Stylianidis, C. P. and Suaide, A. A. P. Sugitate, T. Suire, C. Sukhanov, M. and Suljic, M. Sultanov, R. Sumberia, V Sumowidagdo, S. and Swain, S. Szabo, A. Szarka, I Tabassam, U. Taghavi, S. F. Taillepied, G. Takahashi, J. Tambave, G. J. Tang, S. and Tang, Z. Takaki, J. D. Tapia Tarhini, M. Tarzila, M. G. and Tauro, A. Tejeda Munoz, G. Telesca, A. Terlizzi, L. and Terrevoli, C. Tersimonov, G. Thakur, S. Thomas, D. and Tieulent, R. Tikhonov, A. Timmins, A. R. Tkacik, M. and Toia, A. Topilskaya, N. Toppi, M. Torales-Acosta, F. and Tork, T. Torres, S. R. Trifiro, A. Tripathy, S. and Tripathy, T. Trogolo, S. Trubnikov, V Trzaska, W. H. and Trzcinski, T. P. Trzeciak, B. A. Tumkin, A. Turrisi, R. and Tveter, T. S. Ullaland, K. Uras, A. Urioni, M. Usai, G. L. Vala, M. Valle, N. Vallero, S. van der Kolk, N. and van Doremalen, L. V. R. van Leeuwen, M. Vande Vyvre, P. and Varga, D. Varga, Z. Varga-Kofarago, M. Vasileiou, M. and Vasiliev, A. Doce, O. Vazquez Vechernin, V. Vercellin, E. and Vergara Limon, S. Vermunt, L. Vertesi, R. Verweij, M. and Vickovic, L. Vilakazi, Z. Baillie, O. Villalobos Vino, G. Vinogradov, A. Virgili, T. Vislavicius, V. and Vodopyanov, A. Volkel, B. Volkl, M. A. Voloshin, K. and Voloshin, S. A. Volpe, G. von Haller, B. Vorobyev, I and Voscek, D. Vozniuk, N. Vrlakova, J. Wagner, B. Wang, C. and Wang, D. Weber, M. Weelden, V, R. J. G. Wegrzynek, A. and Wenzel, S. C. Wessels, J. P. Wiechula, J. Wikne, J. and Wilk, G. Wilkinson, J. Willems, G. A. Windelband, B. and Winn, M. Witt, W. E. Wright, J. R. Wu, W. Wu, Y. Xu, R. Yadav, A. K. Yalcin, S. Yamaguchi, Y. Yamakawa, K. and Yang, S. Yano, S. Yasin, Z. Yin, Z. Yokoyama, H. and Yoo, I-K Yoon, J. H. Yuan, S. Yuncu, A. Zaccolo, V and Zampolli, C. Zanoli, H. J. C. Zardoshti, N. Zarochentsev, A. and Zavada, P. Zaviyalov, N. Zhalov, M. Zhang, B. Zhang, S. Zhang, X. Zhang, Y. Zherebchevskii, V Zhi, Y. and Zhigareva, N. Zhou, D. Zhou, Y. Zhu, J. Zhu, Y. and Zichichi, A. Zinovjev, G. Zurlo, N. ALICE Collaboration

Subjects
Nuclear Theory, Nuclear Experiment
Abstract

Understanding the production mechanism of light (anti)nuclei is one of the key challenges of nuclear physics and has important consequences for astrophysics, since it provides an input for indirect dark-matter searches in space. In this paper, the latest results about the production of light (anti)nuclei in pp collisions at root s = 13TeV are presented, focusing on the comparison with the predictions of coalescence and thermal models. For the first time, the coalescence parameters B-2 for deuterons and B-3 for helions are compared with parameter-free theoretical predictions that are directly constrained by the femtoscopic measurement of the source radius in the same event class. A fair description of the data with a Gaussian wave function is observed for both deuteron and helion, supporting the coalescence mechanism for the production of light (anti)nuclei in pp collisions. This method paves the way for future investigations of the internal structure of more complex nuclear clusters, including the hypertriton.

Published
2022

35. Chatbot as a Telehealth Intervention Strategy in the COVID-19 Pandemic

Author

Bruno Azevedo Chagas, Kícila Ferreguetti, Thiago C. Ferreira, Milena S. Marcolino, Leonardo B. Ribeiro, Adriana S. Pagano, Zilma S. N. Reis, Raquel O. Prates, Wagner Meira Jr., and Antonio L. Ribeiro

Subjects
General Medicine
Abstract

The COVID-19 pandemic and the need for social distancing have created a demand for new and innovative solutions in healthcare systems worldwide. One of the strategies that have been implemented are chatbots, which can be helpful in providing reliable health information and preventing people from seeking assistance in healthcare centers and being unnecessarily exposed to the virus. In this context, although a high number of chatbots have been implemented worldwide, little has been discussed about the process and challenges in developing and implementing this technology. This paper reports on an action research, which designed a novel chatbot as a prompt response to the COVID-19 pandemic. The chatbot is intended to be a first layer of interaction with the public, performing triage of patients and providing information about COVID-19 on a large scale and without human contact. Our contribution is twofold: (i) we reflected on the development process and discuss lessons learned and recommendations to support a multidisciplinary development and evolution process of the chatbot; and (ii) we identified some interactive and technological features that can be used as a reference framework for this kind of technology. These contributions can be useful to other researchers and multidisciplinary teams facing similar challenges.

Published
2021
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36. Chatbot as a Telehealth Intervention Strategy in the COVID-19 Pandemic

Author

Bruno Azevedo Chagas, Kícila Ferreguetti, Thiago C. Ferreira, Milena S. Marcolino, Leonardo B. Ribeiro, Adriana S. Pagano, Zilma S. N. Reis, Raquel O. Prates, Wagner Meira Jr., and Antonio L. Ribeiro

Subjects
Action Research, Telehealth, Electronic computers. Computer science, COVID pandemic, QA75.5-76.95, Chatbot
Abstract

The COVID-19 pandemic and the need for social distancing have created a demand for new and innovative solutions in healthcare systems worldwide. One of the strategies that have been implemented are chatbots, which can be helpful in providing reliable health information and preventing people from seeking assistance in healthcare centers and being unnecessarily exposed to the virus. In this context, although a high number of chatbots have been implemented worldwide, little has been discussed about the process and challenges in developing and implementing this technology. This paper reports on an action research, which designed a novel chatbot as a prompt response to the COVID-19 pandemic. The chatbot is intended to be a first layer of interaction with the public, performing triage of patients and providing information about COVID-19 on a large scale and without human contact. Our contribution is twofold: (i) we reflected on the development process and discuss lessons learned and recommendations to support a multidisciplinary development and evolution process of the chatbot; and (ii) we identified some interactive and technological features that can be used as a reference framework for this kind of technology. These contributions can be useful to other researchers and multidisciplinary teams facing similar challenges.

Published
2021

37. Ultra low noise readout with traveling wave parametric amplifiers: The DARTWARS project

Author

A. Rettaroli, C. Barone, M. Borghesi, S. Capelli, G. Carapella, A.P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, V. Granata, A. Greco, C. Guarcello, D. Labranca, A. Leo, C. Ligi, G. Maccarrone, F. Mantegazzini, B. Margesin, G. Maruccio, C. Mauro, R. Mezzena, A.G. Monteduro, A. Nucciotti, L. Oberto, L. Origo, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, S. Rizzato, A. Vinante, M. Zannoni, Rettaroli, A, Barone, C, Borghesi, M, Capelli, S, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Granata, V, Greco, A, Guarcello, C, Labranca, D, Leo, A, Ligi, C, Maccarrone, G, Mantegazzini, F, Margesin, B, Maruccio, G, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Origo, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Vinante, A, and Zannoni, M

Subjects
Quantum Physics, Nuclear and High Energy Physics, Josephson junctions, Microwaves, Low noise, Parametric amplification, Detector arrays, Superconductors, FOS: Physical sciences, Detector array, Josephson junction, Superconductor, Quantum Physics (quant-ph), Microwave, Instrumentation
Abstract

The DARTWARS project has the goal of developing high-performing innovative travelling wave parametric amplifiers with high gain, large bandwidth, high saturation power, and nearly quantum-limited noise. The target frequency region for its applications is 5 - 10 GHz, with an expected noise temperature of about 600 mK. The development follows two different approaches, one based on Josephson junctions and one based on kinetic inductance of superconductors. This contribution mainly focuses on the Josephson travelling wave parametric amplifier, presenting its design, preliminary measurements and the test of homogeneity of arrays of Josephson junctions., 4 pages, 5 figures. Proceeding of Pisa15th Meeting conference. arXiv admin note: text overlap with arXiv:2111.03409

Published
2023
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38. Digital mid-wavelength and long-wavelength infrared focal planes for SmallSat applications

Author

David Z. Ting, Sir B. Rafol, Arezou Khoshakhlagh, Sam A. Keo, Miguel Nunes, Thomas S. Pagano, Luke Flynn, Parminder Ghuman, Tobias Wenger, Michael W. Kelly, Sarath D. Gunapala, Anita M. Fisher, Robert A. Wright, Alexander Soibel, Brian Pepper, Cristopher David, Paul G. Lucey, Cory J. Hill, Justin J. Baker, and Sachidananda Babu

Subjects
Materials science, Infrared, business.industry, Detector, Photodetector, Integrated circuit, Cutoff frequency, law.invention, Wavelength, Operating temperature, law, Optoelectronics, Infrared detector, business
Abstract

In this paper, we will report our recent efforts in achieving high performance in Antimonides type-II superlattice (T2SL) based infrared photodetectors using the barrier infrared detector (BIRD) architecture. The high operating temperature (HOT) BIRD focal plane arrays (FPAs) offer the same high performance, uniformity, operability, manufacturability, and affordability advantages as InSb. However, mid-wavelength infrared (MWIR) HOT-BIRD FPAs can operate at significantly higher temperatures (

Published
2021
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39. Trading and Technology: An Information Systems Course Application

Author

Robert A. Schwartz, Bruce W. Weber, Deniz Ozenbas, and Michael S. Pagano

Subjects
Market structure, Order (exchange), Value (economics), Financial market, Information system, Market system, Business, Drill down, Industrial organization, Computer technology
Abstract

Financial markets today are highly computerized -- from software-driven order submission to price determination to straight-through clearing and settlement -- computer technology has displaced manual activities and streamlined functions throughout the trading value chain. The previous chapters examined microeconomic principles that underpin trading and price-setting, and finance theory that provides analytical frameworks for market outcomes. Our analysis introduces real market frictions and examines how transactions costs and heterogeneity among market participants makes market structure and tracing mechanism design crucial determinants of market outcomes and behavior. . In this chapter, we drill down further into the realities of a non-frictionless market in order to focus on how technology can enhance the efficiency of an actual marketplace. Challenging market design issues are encountered when developing and operating an actual trading facility, and as IT professionals know, the devil is in the details. The practical considerations in operating a market system successfully are the next topic this book addresses.

Published
2021
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40. Liquidity, Trading, and Price Determination in Equity Markets: A Finance Course Application

Author

Deniz Ozenbas, Bruce W. Weber, Robert A. Schwartz, and Michael S. Pagano

Subjects
Finance, Market structure, Portfolio manager, business.industry, Equity (finance), Portfolio, Business, Volatility (finance), Investment (macroeconomics), Price discovery, Market liquidity
Abstract

Trading is the implementation of an investment decision. After a portfolio decision has been made by a portfolio manager, it must be implemented, and especially for handling large orders and navigating stressful markets, specific skills and responsibilities are needed that require the expertise of a professional trader. However, the efficiency with which orders are handled and turned into trades depends, not just on traders’ abilities, but also on a market’s liquidity, on the design of the marketplace where shares are traded, and on the regulatory environment. In this chapter, we cover trading costs, liquidity, volatility, price discovery, market structure, and market structure regulation.

Published
2021
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41. Economics and the Equity Market: A Microeconomics Course Application

Author

Bruce W. Weber, Robert A. Schwartz, Michael S. Pagano, and Deniz Ozenbas

Subjects
Inflation, Consumption (economics), Microeconomics, media_common.quotation_subject, Equity (finance), Economics, Capital asset pricing model, Portfolio, Asset (economics), Modern portfolio theory, media_common, Interest rate
Abstract

Economics encompasses two broad subjects: macroeconomics and microeconomics. Macroeconomics deals with an economy in aggregate and addresses issues such as inflation, unemployment, interest rates, and economic growth. We present a macroeconomic perspective in Chap. 3. Microeconomics, the focus of this chapter, operates, as its name indicates, on the micro level, addressing household consumption decisions and the production decisions of firms. In this chapter, we focus on the parallels (and a few differences) between a standard microeconomics formulation (a household’s selection of an optimal consumption bundle) and a standard finance model (an investor’s selection of a portfolio that optimally combines a riskless asset – cash – and a risky equity portfolio). The finance formulation is the Capital Asset Pricing Model (CAPM). CAPM is a keystone of what is known as modern portfolio theory, the originator of which is Harry Markowitz who was awarded a Nobel Memorial Prize in Economic Sciences in 1990 for having developed the theory of portfolio choice. We then introduce friction (trading costs) and show how CAPM’s frictionless market equilibrium is perturbed. The analysis provides a good lead-in to the next chapter on finance.

Published
2021
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42. Liquidity and the Impact of Information Shocks: A Macroeconomics Course Application

Author

Bruce W. Weber, Deniz Ozenbas, Robert A. Schwartz, and Michael S. Pagano

Subjects
Macroeconomics, Shock (economics), Financial market, Economics, Stock (geology), Market liquidity
Abstract

This chapter explains how “information shocks” can affect the liquidity of financial markets and stock prices. The focus is on unexpected macroeconomic news as a key type of information shock. The final portion of the chapter discusses some realworld events that demonstrate the effects of these shocks on financial markets and how investors react to unexpected macroeconomic news items.

Published
2021
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43. Experiencing Market Dynamics with TraderEx: A Trading Decision-Making Simulation

Author

Bruce W. Weber, Michael S. Pagano, Robert A. Schwartz, and Deniz Ozenbas

Subjects
Work (electrical), Process (engineering), business.industry, Business, Market dynamics, Apprenticeship, Curriculum, Price discovery, Industrial organization, Financial services, Desk
Abstract

Trading education is vital for success in the securities and investments industry. Are apprenticeships and time on an institutional trading desk the only way to learn how to trade? Do you need to work with real orders and have real money at risk to gain experience interacting with the dynamic process of price formation? The answers are no and no. Trading simulations that are well-designed can create experiences with price discovery and impose the challenges of illiquidity in ways that replicate the learning accomplished (and pressures felt) on a real trading desk. With TraderEx, you will appreciate the complexity of trading and understand it as a distinct profession within the financial industry, even if it is not always thought of as such in business school curriculum.

Published
2021
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44. Mid-wavelength and long-wavelength infrared focal planes for SmallSat applications

Author

Anita M. Fisher, Robert A. Wright, Michael W. Kelly, Parminder Ghuman, Arezou Khoshakhlagh, Christopher David, Sam A. Keo, Miguel Nunes, Sir B. Rafol, Thomas S. Pagano, Brian Pepper, Sachidananda Babu, Justin J. Baker, Luke Flynn, Sarath D. Gunapala, Cory J. Hill, Paul G. Lucey, David Z. Ting, and Alexander Soibel

Subjects
Resonator, Wavelength, Materials science, Operating temperature, Infrared, business.industry, Detector, Photodetector, Optoelectronics, Infrared detector, business, Cutoff frequency
Abstract

In this presentation, we will report our recent efforts in achieving high performance in Antimonides type-II superlattice (T2SL) based infrared photodetectors using the barrier infrared detector (BIRD) architecture. The high operating temperature (HOT) BIRD focal plane arrays (FPAs) offer the same high performance, uniformity, operability, manufacturability, and affordability advantages as InSb. However, mid-wavelength infrared (MWIR) HOT-BIRD FPAs can operate at significantly higher temperatures (

Published
2021
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45. Comparison of AIRS and CrIS SNPP and JPSS radiometry between 2018 and 2021

Author

Evan Manning, Steven E. Broberg, Hartmut H. Aumann, and Thomas S. Pagano

Subjects
Arctic, Climatology, Radiometry, Environmental science, Tropical ocean, Absolute calibration, The arctic
Abstract

Aqua-AIRS data have been available now for almost 20 years, Suomi-NPP CrIS for 9 years, and JPSS1 CrIS for 4 years. The three instruments satisfy nearly identical functional requirements, and are in very similar polar orbits. However, there are differences in the design, spatial scan pattern and sun-angle, in addition to absolute calibration differences. We compared AIRS, CrIS SNPP and CrIS JPSS data for the 1148 days between 20180217 and 20210430 for the 900 cm-1 channel under clear and random sampled tropical ocean, tropical land, and Arctic conditions. Although JPSS and SNPP are identical designs, the difference between JPSS and SNPP are as large as the differences relative to AIRS. For the day and night tropical ocean at typically 295K and for night tropical land and under the Arctic conditions (265K typical), averaged over all scan angles, detector elements and time, AIRS, JPSS and SNPP agree within 100 mK. Under Antarctic and Antarctic conditions, the difference between JPSS and AIRS and SNPP and AIRS are on average 200 mK, but with a much larger summer/winter correlated pattern. For clear tropical day (318K), AIRS is 500 mK warmer than JPSS, but 150 mK colder than SNPP. The three instruments find 40% fewer clear cases at night than during the day. With JPSS we find 3% fewer clear cases than with AIRS, 9% more than with SNPP day and night. Differences seen in the past three years in the AIRS, SNPP and JPSS data are calibration artifacts. Unless corrected in the construction of merged AIRS/SNPP/JPSS and follow-on time series, they will complicate the interpretation of trends potentially related to climate change.

Published
2021
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46. Ambient performance testing of the CubeSat Infrared Atmospheric Sounder (CIRAS)

Author

Sir B. Rafol, Thomas U. Kampe, Thomas S. Pagano, Yuki Maruyama, Daniel W. Wilson, Dean L. Johnson, Megan S. Gibson, Brian Monacelli, David Z. Ting, Robert C. Wilson, Juancarlos Soto, Mark A. Schwochert, and James Howell

Subjects
Operating temperature, business.industry, Brassboard, Hyperspectral imaging, Environmental science, CubeSat, Infrared detector, Cryocooler, Aerospace, business, Fabry–Pérot interferometer, Remote sensing
Abstract

Hyperspectral infrared measurements of Earth’s atmosphere from space have proven their value for weather forecasting, climate science and atmospheric composition. The CubeSat Infrared Atmospheric Sounder (CIRAS) instrument will demonstrate a fully functional infrared temperature, water vapor and carbon monoxide sounder in a CubeSat sized volume for at least an order of magnitude lower cost than legacy systems. Design for a CubeSat significantly reduces cost of access to space and enables flight in a constellation to reduce revisit time and enable new measurements including 3D winds. A technology demonstration of CIRAS is currently under development at JPL. The effort has completed integration and ambient testing of a high fidelity brassboard, complete with the flight configured optics assembly developed by Ball Aerospace with a JPL Immersion Grating and Black Silicon Entrance Slit. The brassboard includes a flight-configured High Operating Temperature Barrier Infrared Detector (HOT-BIRD) mounted in an Integrated Dewar Cryocooler Assembly (IDCA), enabling testing in the ambient environment. Ambient testing included radiometric testing of the system to characterize the instrument operability and NEdT. Spatial testing was performed to characterize the system line spread function (LSF) in two axes and report FWHM of the LSF. Spectral testing involved an air path test to characterize the spectral/spatial transformation matrix, and an etalon was used to measure the Spectral Response Functions (SRFs). Results of the testing show the CIRAS performs exceptionally well and meets the key performance required of the system. The end result of testing is the CIRAS instrument now meets TRL 4 with confidence in a brassboard configuration ready for thermal vacuum (TVac) testing necessary to achieve TRL 5 for the system.

Published
2021
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47. Learning spatial response functions from large multi-sensor AIRS and MODIS datasets

Author

Igor Yanovsky, Evan Manning, Steven E. Broberg, Luminita A. Vese, Thomas S. Pagano, and Hartmut H. Aumann

Subjects
Point spread function, Computer science, Atmospheric Infrared Sounder, Calibration, Water vapor absorption, Moderate-resolution imaging spectroradiometer, Inverse problem, Spatial response, Multi sensor, Remote sensing
Abstract

We use large datasets from the Atmospheric Infrared Sounder (AIRS) and the Moderate Resolution Imaging Spectroradiometer (MODIS) to derive AIRS spatial response functions and study their potential variations over the mission. The new reconstructed spatial response functions can be used to reduce errors in the radiances in non-uniform scenes and improve products generated using both AIRS and MODIS data. AIRS spatial response functions are distinct for each of its 2378 channels and each of its 90 scan angles. We develop the mathematical model and the optimization framework for deriving spatial response functions for two AIRS channels with low water vapor absorption and various scan angles. We quantify uncertainties in the derived reconstructions and study how they differ from pre-flight spatial response functions. We show that our approach generates reconstructions that agree with the data more accurately compared to pre-flight spatial responses. We derive spatial response functions using data collected during successive dates in order to ascertain the repeatability of the reconstructed spatial response functions. We also compare the derived spatial response functions based on data collected in the beginning, the middle, and at the current state of the mission in order to study changes in reconstructions over time.

Published
2021
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50. Associations of Cognitive Function and Education Level With All-Cause Mortality in Adults on Hemodialysis: Findings From the COGNITIVE-HD Study

Author

David W. Johnson, Giancarlo Logroscino, R. Fichera, A. Failla, Jörgen Hegbrant, R. Antinoro, M. Meconizzi, A. Bua, Patrizia Natale, D. Rallo, A. Marangelli, A.V. Cagnazzo, S. Messina, Marinella Ruospo, M. Sambati, C. Donatelli, Rosanna Tortelli, F. Grippaldi, Giovanni F.M. Strippoli, G. Matera, Jonathan C. Craig, P. Nasisi, Annalisa Iurillo, D. Bertino, L. Moscardelli, G. Marino, S. Papagni, A. D’Angelo, S. Pagano, Charlotta Wollheim, M. Mantuano, Suetonia C. Palmer, C. Saturno, Germaine Wong, A. Maniscalco, Maria Rosaria Barulli, N. Dambrosio, M. Fici, Marco Murgo, A. Lupo, G. Randazzo, N. Sanfilippo, Marcello Tonelli, Armando Teixeira-Pinto, Clement T. Loy, A. Molino, A. Flammini, G. Latassa, G. Montalto, Letizia Gargano, M. Benevento, S. Campo, E. Boccia, Anita van Zwieten, C. Capostagno, F. Alicino, R. Di Toro Mammarella, F. Pedone, and Valeria Saglimbene

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Population, 030232 urology & nephrology, Cohort Studies, 03 medical and health sciences, Cognition, 0302 clinical medicine, Renal Dialysis, Internal medicine, medicine, Humans, Cognitive Dysfunction, Prospective Studies, 030212 general & internal medicine, Neuropsychological assessment, Mortality, Cognitive decline, education, Prospective cohort study, Dialysis, Aged, Aged, 80 and over, education.field_of_study, medicine.diagnostic_test, Proportional hazards model, business.industry, Middle Aged, 16. Peace & justice, 3. Good health, Nephrology, Educational Status, Kidney Failure, Chronic, Female, Hemodialysis, business
Abstract

Rationale & Objective In the general population, cognitive impairment is associated with increased mortality, and higher levels of education are associated with lower risks for cognitive impairment and mortality. These associations are not well studied in patients receiving long-term hemodialysis and were the focus of the current investigation. Study Design Prospective cohort study. Setting & Participants Adult hemodialysis patients treated in 20 Italian dialysis clinics. Exposures Patients’ cognitive function across 5 domains (memory, attention, executive function, language, and perceptual-motor function), measured using a neuropsychological assessment comprising 10 tests; and patients’ self-reported years of education. Outcome All-cause mortality. Analytical Approach Nested multivariable Cox regression models were used to examine associations of cognition (any domain impaired, number of domains impaired, and global function score from principal components analysis of unadjusted test scores) and education with mortality and whether there were interactions between them. Results 676 (70.6%) patients participated, with a median age of 70.9 years and including 38.8% women. Cognitive impairment was present in 79.4% (527/664; 95% CI, 76.3%-82.5%). During a median follow-up of 3.3 years (1,874 person-years), 206 deaths occurred. Compared to no cognitive impairment, adjusted HRs for mortality were 1.77 (95% CI, 1.07-2.93) for any impairment, 1.48 (95% CI, 0.82-2.68) for 1 domain impaired, 1.88 (95% CI, 1.01-3.53) for 2 domains, and 2.01 (95% CI, 1.14-3.55) for 3 to 5 domains. The adjusted HR was 0.68 (95% CI, 0.51-0.92) per standard deviation increase in global cognitive function score. Compared with primary or lower education, adjusted HRs were 0.79 (95% CI, 0.53-1.20) for lower secondary and 1.13 (95% CI, 0.80-1.59) for upper secondary or higher. The cognition-by-education interaction was not significant (P = 0.7). Limitations Potential selection bias from nonparticipation and missing data; no data for cognitive decline; associations with education were not adjusted for other socioeconomic factors. Conclusions Cognitive impairment is associated with premature mortality in hemodialysis patients. Education does not appear to be associated with mortality.

Published
2019
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